-- dump date 20140620_033136 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1036743000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1036743000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1036743000004 Walker A motif; other site 1036743000005 ATP binding site [chemical binding]; other site 1036743000006 Walker B motif; other site 1036743000007 arginine finger; other site 1036743000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1036743000009 DnaA box-binding interface [nucleotide binding]; other site 1036743000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1036743000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1036743000012 putative DNA binding surface [nucleotide binding]; other site 1036743000013 dimer interface [polypeptide binding]; other site 1036743000014 beta-clamp/clamp loader binding surface; other site 1036743000015 beta-clamp/translesion DNA polymerase binding surface; other site 1036743000016 recombination protein F; Reviewed; Region: recF; PRK00064 1036743000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000018 Walker A/P-loop; other site 1036743000019 ATP binding site [chemical binding]; other site 1036743000020 Q-loop/lid; other site 1036743000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000022 ABC transporter signature motif; other site 1036743000023 Walker B; other site 1036743000024 D-loop; other site 1036743000025 H-loop/switch region; other site 1036743000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1036743000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743000028 Mg2+ binding site [ion binding]; other site 1036743000029 G-X-G motif; other site 1036743000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1036743000031 anchoring element; other site 1036743000032 dimer interface [polypeptide binding]; other site 1036743000033 ATP binding site [chemical binding]; other site 1036743000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1036743000035 active site 1036743000036 putative metal-binding site [ion binding]; other site 1036743000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1036743000038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743000039 non-specific DNA binding site [nucleotide binding]; other site 1036743000040 salt bridge; other site 1036743000041 sequence-specific DNA binding site [nucleotide binding]; other site 1036743000042 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1036743000043 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1036743000044 active site 1036743000045 phosphorylation site [posttranslational modification] 1036743000046 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1036743000047 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1036743000048 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1036743000049 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1036743000050 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1036743000051 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1036743000052 Walker A/P-loop; other site 1036743000053 ATP binding site [chemical binding]; other site 1036743000054 Q-loop/lid; other site 1036743000055 ABC transporter signature motif; other site 1036743000056 Walker B; other site 1036743000057 D-loop; other site 1036743000058 H-loop/switch region; other site 1036743000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1036743000060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1036743000061 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1036743000062 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1036743000063 putative active site [active] 1036743000064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1036743000065 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1036743000066 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1036743000067 catalytic site [active] 1036743000068 putative active site [active] 1036743000069 putative substrate binding site [chemical binding]; other site 1036743000070 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1036743000071 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1036743000072 putative NAD(P) binding site [chemical binding]; other site 1036743000073 active site 1036743000074 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1036743000075 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1036743000076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1036743000077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743000078 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1036743000079 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1036743000080 active site 1036743000081 dimer interface [polypeptide binding]; other site 1036743000082 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1036743000083 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1036743000084 active site 1036743000085 FMN binding site [chemical binding]; other site 1036743000086 substrate binding site [chemical binding]; other site 1036743000087 3Fe-4S cluster binding site [ion binding]; other site 1036743000088 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1036743000089 domain interface; other site 1036743000090 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1036743000091 catalytic residues [active] 1036743000092 dimer interface [polypeptide binding]; other site 1036743000093 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1036743000094 MarR family; Region: MarR; pfam01047 1036743000095 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1036743000096 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1036743000097 C-terminal domain interface [polypeptide binding]; other site 1036743000098 GSH binding site (G-site) [chemical binding]; other site 1036743000099 dimer interface [polypeptide binding]; other site 1036743000100 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1036743000101 N-terminal domain interface [polypeptide binding]; other site 1036743000102 dimer interface [polypeptide binding]; other site 1036743000103 substrate binding pocket (H-site) [chemical binding]; other site 1036743000104 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743000105 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1036743000106 protein binding site [polypeptide binding]; other site 1036743000107 Transglycosylase; Region: Transgly; cl17702 1036743000108 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1036743000109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1036743000110 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1036743000111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743000112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743000113 dimerization interface [polypeptide binding]; other site 1036743000114 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1036743000115 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1036743000116 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1036743000117 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1036743000118 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1036743000119 catalytic residues [active] 1036743000120 central insert; other site 1036743000121 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1036743000122 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1036743000123 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1036743000124 heme exporter protein CcmC; Region: ccmC; TIGR01191 1036743000125 CcmB protein; Region: CcmB; pfam03379 1036743000126 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1036743000127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000128 Walker A/P-loop; other site 1036743000129 ATP binding site [chemical binding]; other site 1036743000130 Q-loop/lid; other site 1036743000131 ABC transporter signature motif; other site 1036743000132 Walker B; other site 1036743000133 D-loop; other site 1036743000134 H-loop/switch region; other site 1036743000135 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1036743000136 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1036743000137 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1036743000138 trimer interface [polypeptide binding]; other site 1036743000139 active site 1036743000140 UDP-GlcNAc binding site [chemical binding]; other site 1036743000141 lipid binding site [chemical binding]; lipid-binding site 1036743000142 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1036743000143 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1036743000144 dimer interface [polypeptide binding]; other site 1036743000145 active site 1036743000146 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1036743000147 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1036743000148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000149 Walker A/P-loop; other site 1036743000150 ATP binding site [chemical binding]; other site 1036743000151 Q-loop/lid; other site 1036743000152 ABC transporter signature motif; other site 1036743000153 Walker B; other site 1036743000154 D-loop; other site 1036743000155 H-loop/switch region; other site 1036743000156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743000157 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1036743000158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743000159 carboxyltransferase (CT) interaction site; other site 1036743000160 biotinylation site [posttranslational modification]; other site 1036743000161 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1036743000162 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1036743000163 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1036743000164 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1036743000165 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743000166 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1036743000167 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1036743000168 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743000169 carboxyltransferase (CT) interaction site; other site 1036743000170 biotinylation site [posttranslational modification]; other site 1036743000171 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1036743000172 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1036743000173 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1036743000174 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 1036743000175 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1036743000176 TPP-binding site; other site 1036743000177 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1036743000178 PYR/PP interface [polypeptide binding]; other site 1036743000179 dimer interface [polypeptide binding]; other site 1036743000180 TPP binding site [chemical binding]; other site 1036743000181 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1036743000182 VacJ like lipoprotein; Region: VacJ; cl01073 1036743000183 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 1036743000184 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1036743000185 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1036743000186 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1036743000187 putative NADP binding site [chemical binding]; other site 1036743000188 putative substrate binding site [chemical binding]; other site 1036743000189 active site 1036743000190 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1036743000191 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1036743000192 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1036743000193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743000194 FeS/SAM binding site; other site 1036743000195 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1036743000196 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 1036743000197 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1036743000198 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1036743000199 Active site cavity [active] 1036743000200 catalytic acid [active] 1036743000201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1036743000202 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1036743000203 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1036743000204 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1036743000205 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1036743000206 active site lid residues [active] 1036743000207 substrate binding pocket [chemical binding]; other site 1036743000208 catalytic residues [active] 1036743000209 substrate-Mg2+ binding site; other site 1036743000210 aspartate-rich region 1; other site 1036743000211 aspartate-rich region 2; other site 1036743000212 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1036743000213 active site lid residues [active] 1036743000214 substrate binding pocket [chemical binding]; other site 1036743000215 catalytic residues [active] 1036743000216 substrate-Mg2+ binding site; other site 1036743000217 aspartate-rich region 1; other site 1036743000218 aspartate-rich region 2; other site 1036743000219 PAS domain S-box; Region: sensory_box; TIGR00229 1036743000220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743000221 putative active site [active] 1036743000222 heme pocket [chemical binding]; other site 1036743000223 PAS domain S-box; Region: sensory_box; TIGR00229 1036743000224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1036743000225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743000226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743000227 dimer interface [polypeptide binding]; other site 1036743000228 phosphorylation site [posttranslational modification] 1036743000229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743000230 ATP binding site [chemical binding]; other site 1036743000231 Mg2+ binding site [ion binding]; other site 1036743000232 G-X-G motif; other site 1036743000233 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 1036743000234 GIY-YIG motif/motif A; other site 1036743000235 putative active site [active] 1036743000236 putative metal binding site [ion binding]; other site 1036743000237 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1036743000238 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1036743000239 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1036743000240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000241 Walker A/P-loop; other site 1036743000242 ATP binding site [chemical binding]; other site 1036743000243 Q-loop/lid; other site 1036743000244 ABC transporter signature motif; other site 1036743000245 Walker B; other site 1036743000246 D-loop; other site 1036743000247 H-loop/switch region; other site 1036743000248 Zinc-finger domain; Region: zf-CHCC; pfam10276 1036743000249 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1036743000250 EamA-like transporter family; Region: EamA; pfam00892 1036743000251 heat shock protein 90; Provisional; Region: PRK05218 1036743000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743000253 ATP binding site [chemical binding]; other site 1036743000254 Mg2+ binding site [ion binding]; other site 1036743000255 G-X-G motif; other site 1036743000256 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1036743000257 30S subunit binding site; other site 1036743000258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743000259 nucleotide binding region [chemical binding]; other site 1036743000260 ATP-binding site [chemical binding]; other site 1036743000261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1036743000262 RNA binding surface [nucleotide binding]; other site 1036743000263 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1036743000264 putative metal binding site [ion binding]; other site 1036743000265 Ferredoxin [Energy production and conversion]; Region: COG1146 1036743000266 4Fe-4S binding domain; Region: Fer4; cl02805 1036743000267 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1036743000268 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1036743000269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000270 putative CheW interface [polypeptide binding]; other site 1036743000271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000272 putative CheW interface [polypeptide binding]; other site 1036743000273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000274 putative CheW interface [polypeptide binding]; other site 1036743000275 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1036743000276 TAP-like protein; Region: Abhydrolase_4; pfam08386 1036743000277 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743000278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743000279 active site 1036743000280 phosphorylation site [posttranslational modification] 1036743000281 intermolecular recognition site; other site 1036743000282 dimerization interface [polypeptide binding]; other site 1036743000283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743000284 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743000285 active site 1036743000286 phosphorylation site [posttranslational modification] 1036743000287 intermolecular recognition site; other site 1036743000288 dimerization interface [polypeptide binding]; other site 1036743000289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743000290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743000291 metal binding site [ion binding]; metal-binding site 1036743000292 active site 1036743000293 I-site; other site 1036743000294 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1036743000295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1036743000296 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1036743000297 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1036743000298 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1036743000299 putative NAD(P) binding site [chemical binding]; other site 1036743000300 dimer interface [polypeptide binding]; other site 1036743000301 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1036743000302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743000303 ATP binding site [chemical binding]; other site 1036743000304 putative Mg++ binding site [ion binding]; other site 1036743000305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743000306 nucleotide binding region [chemical binding]; other site 1036743000307 ATP-binding site [chemical binding]; other site 1036743000308 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1036743000309 HRDC domain; Region: HRDC; pfam00570 1036743000310 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1036743000311 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1036743000312 oligomeric interface; other site 1036743000313 putative active site [active] 1036743000314 homodimer interface [polypeptide binding]; other site 1036743000315 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1036743000316 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1036743000317 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743000318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743000319 dimer interface [polypeptide binding]; other site 1036743000320 conserved gate region; other site 1036743000321 putative PBP binding loops; other site 1036743000322 ABC-ATPase subunit interface; other site 1036743000323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1036743000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743000325 dimer interface [polypeptide binding]; other site 1036743000326 conserved gate region; other site 1036743000327 putative PBP binding loops; other site 1036743000328 ABC-ATPase subunit interface; other site 1036743000329 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1036743000330 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1036743000331 Walker A/P-loop; other site 1036743000332 ATP binding site [chemical binding]; other site 1036743000333 Q-loop/lid; other site 1036743000334 ABC transporter signature motif; other site 1036743000335 Walker B; other site 1036743000336 D-loop; other site 1036743000337 H-loop/switch region; other site 1036743000338 TOBE domain; Region: TOBE; pfam03459 1036743000339 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743000340 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743000341 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743000342 hypothetical protein; Provisional; Region: PRK09256 1036743000343 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1036743000344 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1036743000345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1036743000346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743000347 catalytic residue [active] 1036743000348 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1036743000349 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1036743000350 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1036743000351 anti sigma factor interaction site; other site 1036743000352 regulatory phosphorylation site [posttranslational modification]; other site 1036743000353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 1036743000354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743000355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743000356 metal binding site [ion binding]; metal-binding site 1036743000357 active site 1036743000358 I-site; other site 1036743000359 SlyX; Region: SlyX; pfam04102 1036743000360 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1036743000361 MG2 domain; Region: A2M_N; pfam01835 1036743000362 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1036743000363 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1036743000364 surface patch; other site 1036743000365 thioester region; other site 1036743000366 specificity defining residues; other site 1036743000367 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 1036743000368 Transglycosylase; Region: Transgly; pfam00912 1036743000369 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1036743000370 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1036743000371 AAA domain; Region: AAA_22; pfam13401 1036743000372 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1036743000373 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1036743000374 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1036743000375 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1036743000376 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743000377 Walker A motif; other site 1036743000378 ATP binding site [chemical binding]; other site 1036743000379 Walker B motif; other site 1036743000380 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1036743000381 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1036743000382 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1036743000383 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1036743000384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000385 Walker A/P-loop; other site 1036743000386 ATP binding site [chemical binding]; other site 1036743000387 ABC transporter signature motif; other site 1036743000388 Walker B; other site 1036743000389 D-loop; other site 1036743000390 H-loop/switch region; other site 1036743000391 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1036743000392 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743000393 Walker A motif; other site 1036743000394 ATP binding site [chemical binding]; other site 1036743000395 Walker B motif; other site 1036743000396 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1036743000397 heme-binding site [chemical binding]; other site 1036743000398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743000399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000400 dimer interface [polypeptide binding]; other site 1036743000401 putative CheW interface [polypeptide binding]; other site 1036743000402 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1036743000403 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1036743000404 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1036743000405 putative ribose interaction site [chemical binding]; other site 1036743000406 putative ADP binding site [chemical binding]; other site 1036743000407 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1036743000408 active site 1036743000409 nucleotide binding site [chemical binding]; other site 1036743000410 HIGH motif; other site 1036743000411 KMSKS motif; other site 1036743000412 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1036743000413 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1036743000414 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1036743000415 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1036743000416 Walker A/P-loop; other site 1036743000417 ATP binding site [chemical binding]; other site 1036743000418 Q-loop/lid; other site 1036743000419 ABC transporter signature motif; other site 1036743000420 Walker B; other site 1036743000421 D-loop; other site 1036743000422 H-loop/switch region; other site 1036743000423 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1036743000424 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1036743000425 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1036743000426 potential protein location (hypothetical protein F11_00655 [Rhodospirillum rubrum F11]) that overlaps RNA (tRNA-R) 1036743000427 PAS fold; Region: PAS_3; pfam08447 1036743000428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743000429 putative active site [active] 1036743000430 heme pocket [chemical binding]; other site 1036743000431 PAS fold; Region: PAS_3; pfam08447 1036743000432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743000433 putative active site [active] 1036743000434 heme pocket [chemical binding]; other site 1036743000435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000436 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1036743000437 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1036743000438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743000439 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1036743000440 succinic semialdehyde dehydrogenase; Region: PLN02278 1036743000441 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1036743000442 tetramerization interface [polypeptide binding]; other site 1036743000443 NAD(P) binding site [chemical binding]; other site 1036743000444 catalytic residues [active] 1036743000445 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1036743000446 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1036743000447 EamA-like transporter family; Region: EamA; pfam00892 1036743000448 EamA-like transporter family; Region: EamA; pfam00892 1036743000449 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1036743000450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743000451 membrane-bound complex binding site; other site 1036743000452 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1036743000453 interface (dimer of trimers) [polypeptide binding]; other site 1036743000454 Substrate-binding/catalytic site; other site 1036743000455 Zn-binding sites [ion binding]; other site 1036743000456 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1036743000457 MarR family; Region: MarR; pfam01047 1036743000458 Cupin domain; Region: Cupin_2; pfam07883 1036743000459 Helix-turn-helix domain; Region: HTH_18; pfam12833 1036743000460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743000461 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1036743000462 dimer interface [polypeptide binding]; other site 1036743000463 active site 1036743000464 Schiff base residues; other site 1036743000465 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1036743000466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743000467 Coenzyme A binding pocket [chemical binding]; other site 1036743000468 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1036743000469 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1036743000470 active site 1036743000471 FMN binding site [chemical binding]; other site 1036743000472 substrate binding site [chemical binding]; other site 1036743000473 homotetramer interface [polypeptide binding]; other site 1036743000474 catalytic residue [active] 1036743000475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743000476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743000477 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1036743000478 dimer interface [polypeptide binding]; other site 1036743000479 substrate binding site [chemical binding]; other site 1036743000480 metal binding sites [ion binding]; metal-binding site 1036743000481 muropeptide transporter; Validated; Region: ampG; cl17669 1036743000482 muropeptide transporter; Validated; Region: ampG; cl17669 1036743000483 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1036743000484 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1036743000485 G1 box; other site 1036743000486 putative GEF interaction site [polypeptide binding]; other site 1036743000487 GTP/Mg2+ binding site [chemical binding]; other site 1036743000488 Switch I region; other site 1036743000489 G2 box; other site 1036743000490 G3 box; other site 1036743000491 Switch II region; other site 1036743000492 G4 box; other site 1036743000493 G5 box; other site 1036743000494 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1036743000495 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1036743000496 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1036743000497 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1036743000498 substrate binding site [chemical binding]; other site 1036743000499 ATP binding site [chemical binding]; other site 1036743000500 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1036743000501 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1036743000502 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1036743000503 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1036743000504 minor groove reading motif; other site 1036743000505 helix-hairpin-helix signature motif; other site 1036743000506 substrate binding pocket [chemical binding]; other site 1036743000507 active site 1036743000508 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1036743000509 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1036743000510 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1036743000511 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1036743000512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743000513 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1036743000514 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1036743000515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743000516 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743000517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743000518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1036743000519 putative substrate translocation pore; other site 1036743000520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743000521 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743000522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743000523 dimerization interface [polypeptide binding]; other site 1036743000524 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743000525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000526 dimer interface [polypeptide binding]; other site 1036743000527 putative CheW interface [polypeptide binding]; other site 1036743000528 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1036743000529 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1036743000530 generic binding surface II; other site 1036743000531 generic binding surface I; other site 1036743000532 Usg-like family; Region: Usg; pfam06233 1036743000533 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1036743000534 oligomerisation interface [polypeptide binding]; other site 1036743000535 mobile loop; other site 1036743000536 roof hairpin; other site 1036743000537 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1036743000538 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1036743000539 ring oligomerisation interface [polypeptide binding]; other site 1036743000540 ATP/Mg binding site [chemical binding]; other site 1036743000541 stacking interactions; other site 1036743000542 hinge regions; other site 1036743000543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743000544 non-specific DNA binding site [nucleotide binding]; other site 1036743000545 salt bridge; other site 1036743000546 sequence-specific DNA binding site [nucleotide binding]; other site 1036743000547 putative transporter; Provisional; Region: PRK11660 1036743000548 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1036743000549 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1036743000550 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1036743000551 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1036743000552 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1036743000553 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1036743000554 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1036743000555 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1036743000556 CT1975-like protein; Region: Cas_CT1975; pfam09344 1036743000557 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1036743000558 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1036743000559 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1036743000560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1036743000561 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1036743000562 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743000563 inhibitor-cofactor binding pocket; inhibition site 1036743000564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743000565 catalytic residue [active] 1036743000566 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1036743000567 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1036743000568 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1036743000569 catalytic residue [active] 1036743000570 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1036743000571 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1036743000572 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1036743000573 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1036743000574 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1036743000575 oligomer interface [polypeptide binding]; other site 1036743000576 RAMP superfamily; Region: RAMPs; pfam03787 1036743000577 CRISPR-associated protein; Region: TIGR03986 1036743000578 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743000579 DNA-binding site [nucleotide binding]; DNA binding site 1036743000580 RNA-binding motif; other site 1036743000581 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1036743000582 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1036743000583 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1036743000584 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743000585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743000586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000587 Walker A/P-loop; other site 1036743000588 ATP binding site [chemical binding]; other site 1036743000589 Q-loop/lid; other site 1036743000590 ABC transporter signature motif; other site 1036743000591 Walker B; other site 1036743000592 D-loop; other site 1036743000593 H-loop/switch region; other site 1036743000594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743000595 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743000596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743000597 Walker A/P-loop; other site 1036743000598 ATP binding site [chemical binding]; other site 1036743000599 Q-loop/lid; other site 1036743000600 ABC transporter signature motif; other site 1036743000601 Walker B; other site 1036743000602 D-loop; other site 1036743000603 H-loop/switch region; other site 1036743000604 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743000605 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743000606 N-terminal plug; other site 1036743000607 ligand-binding site [chemical binding]; other site 1036743000608 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 1036743000609 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1036743000610 putative efflux protein, MATE family; Region: matE; TIGR00797 1036743000611 cation binding site [ion binding]; other site 1036743000612 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1036743000613 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1036743000614 dimer interface [polypeptide binding]; other site 1036743000615 active site 1036743000616 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1036743000617 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 1036743000618 Restriction endonuclease; Region: Mrr_cat; pfam04471 1036743000619 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1036743000620 putative catalytic site [active] 1036743000621 putative metal binding site [ion binding]; other site 1036743000622 putative phosphate binding site [ion binding]; other site 1036743000623 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1036743000624 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1036743000625 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1036743000626 putative active site [active] 1036743000627 putative active site [active] 1036743000628 catalytic site [active] 1036743000629 catalytic site [active] 1036743000630 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1036743000631 putative active site [active] 1036743000632 catalytic site [active] 1036743000633 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1036743000634 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1036743000635 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1036743000636 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1036743000637 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1036743000638 HSP70 interaction site [polypeptide binding]; other site 1036743000639 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1036743000640 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1036743000641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1036743000642 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1036743000643 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 1036743000644 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1036743000645 metal ion-dependent adhesion site (MIDAS); other site 1036743000646 SWIM zinc finger; Region: SWIM; pfam04434 1036743000647 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1036743000648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743000649 ATP binding site [chemical binding]; other site 1036743000650 putative Mg++ binding site [ion binding]; other site 1036743000651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743000652 nucleotide binding region [chemical binding]; other site 1036743000653 ATP-binding site [chemical binding]; other site 1036743000654 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1036743000655 putative active site [active] 1036743000656 metal binding site [ion binding]; metal-binding site 1036743000657 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1036743000658 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1036743000659 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1036743000660 nudix motif; other site 1036743000661 EamA-like transporter family; Region: EamA; pfam00892 1036743000662 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1036743000663 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743000664 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1036743000665 putative DNA binding site [nucleotide binding]; other site 1036743000666 putative Zn2+ binding site [ion binding]; other site 1036743000667 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743000668 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1036743000669 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1036743000670 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1036743000671 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1036743000672 Phosphoglycerate kinase; Region: PGK; pfam00162 1036743000673 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1036743000674 substrate binding site [chemical binding]; other site 1036743000675 hinge regions; other site 1036743000676 ADP binding site [chemical binding]; other site 1036743000677 catalytic site [active] 1036743000678 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1036743000679 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1036743000680 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1036743000681 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1036743000682 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1036743000683 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1036743000684 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1036743000685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743000686 FeS/SAM binding site; other site 1036743000687 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1036743000688 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1036743000689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743000690 putative substrate translocation pore; other site 1036743000691 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 1036743000692 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1036743000693 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1036743000694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743000695 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1036743000696 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1036743000697 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743000698 active site 1036743000699 dimer interface [polypeptide binding]; other site 1036743000700 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743000701 Ligand Binding Site [chemical binding]; other site 1036743000702 Molecular Tunnel; other site 1036743000703 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1036743000704 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1036743000705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1036743000706 ATP binding site [chemical binding]; other site 1036743000707 putative Mg++ binding site [ion binding]; other site 1036743000708 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1036743000709 SEC-C motif; Region: SEC-C; pfam02810 1036743000710 camphor resistance protein CrcB; Provisional; Region: PRK14206 1036743000711 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1036743000712 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1036743000713 nudix motif; other site 1036743000714 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1036743000715 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1036743000716 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1036743000717 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1036743000718 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1036743000719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1036743000720 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1036743000721 active site 1036743000722 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1036743000723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743000724 S-adenosylmethionine binding site [chemical binding]; other site 1036743000725 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1036743000726 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1036743000727 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1036743000728 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1036743000729 putative ligand binding site [chemical binding]; other site 1036743000730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743000731 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1036743000732 TM-ABC transporter signature motif; other site 1036743000733 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1036743000734 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1036743000735 Walker A/P-loop; other site 1036743000736 ATP binding site [chemical binding]; other site 1036743000737 Q-loop/lid; other site 1036743000738 ABC transporter signature motif; other site 1036743000739 Walker B; other site 1036743000740 D-loop; other site 1036743000741 H-loop/switch region; other site 1036743000742 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1036743000743 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1036743000744 N- and C-terminal domain interface [polypeptide binding]; other site 1036743000745 D-xylulose kinase; Region: XylB; TIGR01312 1036743000746 active site 1036743000747 MgATP binding site [chemical binding]; other site 1036743000748 catalytic site [active] 1036743000749 metal binding site [ion binding]; metal-binding site 1036743000750 xylulose binding site [chemical binding]; other site 1036743000751 putative homodimer interface [polypeptide binding]; other site 1036743000752 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743000754 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1036743000755 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1036743000756 inhibitor binding site; inhibition site 1036743000757 catalytic Zn binding site [ion binding]; other site 1036743000758 structural Zn binding site [ion binding]; other site 1036743000759 NADP binding site [chemical binding]; other site 1036743000760 tetramer interface [polypeptide binding]; other site 1036743000761 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1036743000762 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1036743000763 NADP-binding site; other site 1036743000764 homotetramer interface [polypeptide binding]; other site 1036743000765 substrate binding site [chemical binding]; other site 1036743000766 homodimer interface [polypeptide binding]; other site 1036743000767 active site 1036743000768 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1036743000769 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1036743000770 NADP binding site [chemical binding]; other site 1036743000771 active site 1036743000772 putative substrate binding site [chemical binding]; other site 1036743000773 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1036743000774 Peptidase family M48; Region: Peptidase_M48; cl12018 1036743000775 carbon starvation protein A; Provisional; Region: PRK15015 1036743000776 Carbon starvation protein CstA; Region: CstA; pfam02554 1036743000777 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1036743000778 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1036743000779 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1036743000780 heme-binding site [chemical binding]; other site 1036743000781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743000782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743000783 dimer interface [polypeptide binding]; other site 1036743000784 putative CheW interface [polypeptide binding]; other site 1036743000785 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 1036743000786 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1036743000787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743000788 binding surface 1036743000789 TPR repeat; Region: TPR_11; pfam13414 1036743000790 TPR motif; other site 1036743000791 TPR repeat; Region: TPR_11; pfam13414 1036743000792 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1036743000793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1036743000794 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1036743000795 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1036743000796 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1036743000797 Fe-S cluster binding site [ion binding]; other site 1036743000798 active site 1036743000799 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1036743000800 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1036743000801 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1036743000802 catalytic residue [active] 1036743000803 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1036743000804 MPT binding site; other site 1036743000805 trimer interface [polypeptide binding]; other site 1036743000806 OmpA family; Region: OmpA; pfam00691 1036743000807 ligand binding site [chemical binding]; other site 1036743000808 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1036743000809 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1036743000810 homodecamer interface [polypeptide binding]; other site 1036743000811 GTP cyclohydrolase I; Provisional; Region: PLN03044 1036743000812 active site 1036743000813 putative catalytic site residues [active] 1036743000814 zinc binding site [ion binding]; other site 1036743000815 GTP-CH-I/GFRP interaction surface; other site 1036743000816 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1036743000817 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1036743000818 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1036743000819 NAD(P) binding site [chemical binding]; other site 1036743000820 homotetramer interface [polypeptide binding]; other site 1036743000821 homodimer interface [polypeptide binding]; other site 1036743000822 active site 1036743000823 putative acyltransferase; Provisional; Region: PRK05790 1036743000824 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1036743000825 dimer interface [polypeptide binding]; other site 1036743000826 active site 1036743000827 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1036743000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 1036743000829 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1036743000830 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1036743000831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743000832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743000833 non-specific DNA binding site [nucleotide binding]; other site 1036743000834 salt bridge; other site 1036743000835 sequence-specific DNA binding site [nucleotide binding]; other site 1036743000836 epoxyqueuosine reductase; Region: TIGR00276 1036743000837 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1036743000838 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1036743000839 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1036743000840 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1036743000841 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1036743000842 Predicted membrane protein [Function unknown]; Region: COG1971 1036743000843 Domain of unknown function DUF; Region: DUF204; pfam02659 1036743000844 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1036743000845 thiamine pyrophosphate protein; Validated; Region: PRK08199 1036743000846 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1036743000847 PYR/PP interface [polypeptide binding]; other site 1036743000848 dimer interface [polypeptide binding]; other site 1036743000849 TPP binding site [chemical binding]; other site 1036743000850 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1036743000851 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1036743000852 TPP-binding site [chemical binding]; other site 1036743000853 aldehyde dehydrogenase family 7 member; Region: PLN02315 1036743000854 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1036743000855 tetrameric interface [polypeptide binding]; other site 1036743000856 NAD binding site [chemical binding]; other site 1036743000857 catalytic residues [active] 1036743000858 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 1036743000859 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1036743000860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1036743000861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1036743000862 active site 1036743000863 catalytic tetrad [active] 1036743000864 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1036743000865 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1036743000866 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1036743000867 putative NADH binding site [chemical binding]; other site 1036743000868 putative active site [active] 1036743000869 nudix motif; other site 1036743000870 putative metal binding site [ion binding]; other site 1036743000871 Membrane transport protein; Region: Mem_trans; cl09117 1036743000872 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1036743000873 IHF dimer interface [polypeptide binding]; other site 1036743000874 IHF - DNA interface [nucleotide binding]; other site 1036743000875 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1036743000876 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1036743000877 RNA binding site [nucleotide binding]; other site 1036743000878 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1036743000879 RNA binding site [nucleotide binding]; other site 1036743000880 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1036743000881 RNA binding site [nucleotide binding]; other site 1036743000882 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1036743000883 RNA binding site [nucleotide binding]; other site 1036743000884 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1036743000885 RNA binding site [nucleotide binding]; other site 1036743000886 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1036743000887 RNA binding site [nucleotide binding]; other site 1036743000888 cytidylate kinase; Provisional; Region: cmk; PRK00023 1036743000889 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1036743000890 CMP-binding site; other site 1036743000891 The sites determining sugar specificity; other site 1036743000892 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1036743000893 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1036743000894 hinge; other site 1036743000895 active site 1036743000896 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1036743000897 TIGR02300 family protein; Region: FYDLN_acid 1036743000898 S-formylglutathione hydrolase; Region: PLN02442 1036743000899 Predicted esterase [General function prediction only]; Region: COG0627 1036743000900 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1036743000901 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1036743000902 NAD(P) binding site [chemical binding]; other site 1036743000903 catalytic residues [active] 1036743000904 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1036743000905 catalytic triad [active] 1036743000906 aminotransferase; Provisional; Region: PRK13356 1036743000907 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1036743000908 homodimer interface [polypeptide binding]; other site 1036743000909 substrate-cofactor binding pocket; other site 1036743000910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743000911 catalytic residue [active] 1036743000912 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1036743000913 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1036743000914 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743000915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743000916 non-specific DNA binding site [nucleotide binding]; other site 1036743000917 salt bridge; other site 1036743000918 sequence-specific DNA binding site [nucleotide binding]; other site 1036743000919 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1036743000920 dimerization interface [polypeptide binding]; other site 1036743000921 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1036743000922 ATP binding site [chemical binding]; other site 1036743000923 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1036743000924 Hydrogenase formation hypA family; Region: HypD; pfam01924 1036743000925 HupF/HypC family; Region: HupF_HypC; pfam01455 1036743000926 Acylphosphatase; Region: Acylphosphatase; pfam00708 1036743000927 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1036743000928 HypF finger; Region: zf-HYPF; pfam07503 1036743000929 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1036743000930 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1036743000931 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1036743000932 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1036743000933 4Fe-4S binding domain; Region: Fer4; pfam00037 1036743000934 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1036743000935 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 1036743000936 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1036743000937 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1036743000938 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1036743000939 hydrogenase 4 subunit D; Validated; Region: PRK06525 1036743000940 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1036743000941 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743000942 hydrogenase 4 subunit B; Validated; Region: PRK06521 1036743000943 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743000944 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1036743000945 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1036743000946 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1036743000947 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1036743000948 NADH dehydrogenase; Region: NADHdh; cl00469 1036743000949 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1036743000950 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1036743000951 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1036743000952 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743000953 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1036743000954 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1036743000955 nickel binding site [ion binding]; other site 1036743000956 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1036743000957 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1036743000958 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1036743000959 [4Fe-4S] binding site [ion binding]; other site 1036743000960 molybdopterin cofactor binding site; other site 1036743000961 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1036743000962 molybdopterin cofactor binding site; other site 1036743000963 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1036743000964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743000965 FeS/SAM binding site; other site 1036743000966 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1036743000967 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1036743000968 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1036743000969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743000970 Walker A motif; other site 1036743000971 ATP binding site [chemical binding]; other site 1036743000972 Walker B motif; other site 1036743000973 arginine finger; other site 1036743000974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743000975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743000976 dimer interface [polypeptide binding]; other site 1036743000977 phosphorylation site [posttranslational modification] 1036743000978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743000979 ATP binding site [chemical binding]; other site 1036743000980 Mg2+ binding site [ion binding]; other site 1036743000981 G-X-G motif; other site 1036743000982 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1036743000983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743000984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743000985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743000986 dimerization interface [polypeptide binding]; other site 1036743000987 EamA-like transporter family; Region: EamA; pfam00892 1036743000988 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1036743000989 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1036743000990 C-terminal domain interface [polypeptide binding]; other site 1036743000991 GSH binding site (G-site) [chemical binding]; other site 1036743000992 dimer interface [polypeptide binding]; other site 1036743000993 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1036743000994 N-terminal domain interface [polypeptide binding]; other site 1036743000995 putative dimer interface [polypeptide binding]; other site 1036743000996 active site 1036743000997 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1036743000998 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1036743000999 dimerization interface [polypeptide binding]; other site 1036743001000 DPS ferroxidase diiron center [ion binding]; other site 1036743001001 ion pore; other site 1036743001002 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1036743001003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743001004 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1036743001005 dimerization interface [polypeptide binding]; other site 1036743001006 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1036743001007 putative deacylase active site [active] 1036743001008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743001009 S-adenosylmethionine binding site [chemical binding]; other site 1036743001010 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1036743001011 Predicted transcriptional regulators [Transcription]; Region: COG1733 1036743001012 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1036743001013 SnoaL-like domain; Region: SnoaL_2; pfam12680 1036743001014 short chain dehydrogenase; Provisional; Region: PRK06523 1036743001015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743001016 NAD(P) binding site [chemical binding]; other site 1036743001017 active site 1036743001018 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1036743001019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1036743001020 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1036743001021 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 1036743001022 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 1036743001023 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1036743001024 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1036743001025 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1036743001026 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1036743001027 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1036743001028 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1036743001029 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1036743001030 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1036743001031 Replication initiator protein A; Region: RPA; pfam10134 1036743001032 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1036743001033 Helix-turn-helix domain; Region: HTH_38; pfam13936 1036743001034 integrase; Provisional; Region: PRK09692 1036743001035 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1036743001036 active site 1036743001037 Int/Topo IB signature motif; other site 1036743001038 GMP synthase; Reviewed; Region: guaA; PRK00074 1036743001039 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1036743001040 AMP/PPi binding site [chemical binding]; other site 1036743001041 candidate oxyanion hole; other site 1036743001042 catalytic triad [active] 1036743001043 potential glutamine specificity residues [chemical binding]; other site 1036743001044 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1036743001045 ATP Binding subdomain [chemical binding]; other site 1036743001046 Ligand Binding sites [chemical binding]; other site 1036743001047 Dimerization subdomain; other site 1036743001048 isocitrate dehydrogenase; Validated; Region: PRK08299 1036743001049 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1036743001050 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1036743001051 heme binding pocket [chemical binding]; other site 1036743001052 heme ligand [chemical binding]; other site 1036743001053 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1036743001054 intersubunit interface [polypeptide binding]; other site 1036743001055 active site 1036743001056 Zn2+ binding site [ion binding]; other site 1036743001057 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1036743001058 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1036743001059 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 1036743001060 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1036743001061 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1036743001062 Qi binding site; other site 1036743001063 cytochrome b; Provisional; Region: CYTB; MTH00156 1036743001064 intrachain domain interface; other site 1036743001065 interchain domain interface [polypeptide binding]; other site 1036743001066 heme bH binding site [chemical binding]; other site 1036743001067 heme bL binding site [chemical binding]; other site 1036743001068 Qo binding site; other site 1036743001069 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1036743001070 interchain domain interface [polypeptide binding]; other site 1036743001071 intrachain domain interface; other site 1036743001072 Qi binding site; other site 1036743001073 Qo binding site; other site 1036743001074 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1036743001075 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1036743001076 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1036743001077 [2Fe-2S] cluster binding site [ion binding]; other site 1036743001078 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1036743001079 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1036743001080 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1036743001081 active site 1036743001082 NTP binding site [chemical binding]; other site 1036743001083 metal binding triad [ion binding]; metal-binding site 1036743001084 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1036743001085 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1036743001086 putative active site [active] 1036743001087 putative CoA binding site [chemical binding]; other site 1036743001088 nudix motif; other site 1036743001089 metal binding site [ion binding]; metal-binding site 1036743001090 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1036743001091 MoxR-like ATPases [General function prediction only]; Region: COG0714 1036743001092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1036743001093 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1036743001094 Protein of unknown function DUF58; Region: DUF58; pfam01882 1036743001095 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1036743001096 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1036743001097 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1036743001098 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1036743001099 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1036743001100 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1036743001101 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1036743001102 putative dimer interface [polypeptide binding]; other site 1036743001103 N-terminal domain interface [polypeptide binding]; other site 1036743001104 putative substrate binding pocket (H-site) [chemical binding]; other site 1036743001105 Pirin-related protein [General function prediction only]; Region: COG1741 1036743001106 Pirin; Region: Pirin; pfam02678 1036743001107 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1036743001108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001109 active site 1036743001110 phosphorylation site [posttranslational modification] 1036743001111 intermolecular recognition site; other site 1036743001112 dimerization interface [polypeptide binding]; other site 1036743001113 LytTr DNA-binding domain; Region: LytTR; pfam04397 1036743001114 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1036743001115 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1036743001116 GAF domain; Region: GAF; cl17456 1036743001117 Histidine kinase; Region: His_kinase; pfam06580 1036743001118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743001119 ATP binding site [chemical binding]; other site 1036743001120 Mg2+ binding site [ion binding]; other site 1036743001121 G-X-G motif; other site 1036743001122 Bacterial SH3 domain; Region: SH3_3; pfam08239 1036743001123 flavodoxin FldA; Validated; Region: PRK09267 1036743001124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1036743001125 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1036743001126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1036743001127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743001128 putative substrate translocation pore; other site 1036743001129 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1036743001130 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1036743001131 DNA binding residues [nucleotide binding] 1036743001132 putative dimer interface [polypeptide binding]; other site 1036743001133 putative metal binding residues [ion binding]; other site 1036743001134 Variant SH3 domain; Region: SH3_2; pfam07653 1036743001135 peptide ligand binding site [polypeptide binding]; other site 1036743001136 Src Homology 3 domain superfamily; Region: SH3; cl17036 1036743001137 peptide ligand binding site [polypeptide binding]; other site 1036743001138 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1036743001139 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1036743001140 putative NAD(P) binding site [chemical binding]; other site 1036743001141 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1036743001142 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1036743001143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743001144 putative DNA binding site [nucleotide binding]; other site 1036743001145 dimerization interface [polypeptide binding]; other site 1036743001146 putative Zn2+ binding site [ion binding]; other site 1036743001147 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1036743001148 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1036743001149 EamA-like transporter family; Region: EamA; pfam00892 1036743001150 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1036743001151 hypothetical protein; Provisional; Region: nrdC.11; PHA02603 1036743001152 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1036743001153 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1036743001154 putative MPT binding site; other site 1036743001155 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1036743001156 active site 1036743001157 8-oxo-dGMP binding site [chemical binding]; other site 1036743001158 nudix motif; other site 1036743001159 metal binding site [ion binding]; metal-binding site 1036743001160 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1036743001161 heterotetramer interface [polypeptide binding]; other site 1036743001162 active site pocket [active] 1036743001163 cleavage site 1036743001164 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1036743001165 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1036743001166 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1036743001167 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1036743001168 active site 1036743001169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743001170 substrate binding site [chemical binding]; other site 1036743001171 catalytic residues [active] 1036743001172 dimer interface [polypeptide binding]; other site 1036743001173 argininosuccinate lyase; Provisional; Region: PRK00855 1036743001174 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1036743001175 active sites [active] 1036743001176 tetramer interface [polypeptide binding]; other site 1036743001177 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1036743001178 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1036743001179 catalytic residues [active] 1036743001180 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 1036743001181 active site 1036743001182 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1036743001183 RES domain; Region: RES; smart00953 1036743001184 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1036743001185 classical (c) SDRs; Region: SDR_c; cd05233 1036743001186 NAD(P) binding site [chemical binding]; other site 1036743001187 active site 1036743001188 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1036743001189 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1036743001190 active site 1036743001191 tetramer interface [polypeptide binding]; other site 1036743001192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743001193 active site 1036743001194 Colicin V production protein; Region: Colicin_V; pfam02674 1036743001195 DNA repair protein RadA; Provisional; Region: PRK11823 1036743001196 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743001197 Walker A motif; other site 1036743001198 ATP binding site [chemical binding]; other site 1036743001199 Walker B motif; other site 1036743001200 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1036743001201 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1036743001202 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1036743001203 Walker A/P-loop; other site 1036743001204 ATP binding site [chemical binding]; other site 1036743001205 Q-loop/lid; other site 1036743001206 ABC transporter signature motif; other site 1036743001207 Walker B; other site 1036743001208 D-loop; other site 1036743001209 H-loop/switch region; other site 1036743001210 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1036743001211 Permease; Region: Permease; pfam02405 1036743001212 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1036743001213 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1036743001214 active site 1036743001215 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743001216 dimer interface [polypeptide binding]; other site 1036743001217 substrate binding site [chemical binding]; other site 1036743001218 catalytic residues [active] 1036743001219 replicative DNA helicase; Provisional; Region: PRK09165 1036743001220 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1036743001221 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1036743001222 Walker A motif; other site 1036743001223 ATP binding site [chemical binding]; other site 1036743001224 Walker B motif; other site 1036743001225 DNA binding loops [nucleotide binding] 1036743001226 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1036743001227 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1036743001228 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1036743001229 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1036743001230 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1036743001231 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1036743001232 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1036743001233 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1036743001234 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1036743001235 NAD(P) binding site [chemical binding]; other site 1036743001236 homotetramer interface [polypeptide binding]; other site 1036743001237 homodimer interface [polypeptide binding]; other site 1036743001238 active site 1036743001239 acyl carrier protein; Provisional; Region: acpP; PRK00982 1036743001240 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1036743001241 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1036743001242 dimer interface [polypeptide binding]; other site 1036743001243 active site 1036743001244 YceG-like family; Region: YceG; pfam02618 1036743001245 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1036743001246 dimerization interface [polypeptide binding]; other site 1036743001247 PRC-barrel domain; Region: PRC; pfam05239 1036743001248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743001249 NAD(P) binding site [chemical binding]; other site 1036743001250 active site 1036743001251 hypothetical protein; Provisional; Region: PRK11820 1036743001252 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1036743001253 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1036743001254 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1036743001255 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1036743001256 catalytic site [active] 1036743001257 G-X2-G-X-G-K; other site 1036743001258 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1036743001259 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1036743001260 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1036743001261 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1036743001262 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1036743001263 SurA N-terminal domain; Region: SurA_N; pfam09312 1036743001264 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1036743001265 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1036743001266 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1036743001267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1036743001268 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1036743001269 active site 1036743001270 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1036743001271 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1036743001272 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1036743001273 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743001274 ligand binding site [chemical binding]; other site 1036743001275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743001276 PAS domain S-box; Region: sensory_box; TIGR00229 1036743001277 PAS domain; Region: PAS; smart00091 1036743001278 putative active site [active] 1036743001279 heme pocket [chemical binding]; other site 1036743001280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743001281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743001282 ATP binding site [chemical binding]; other site 1036743001283 Mg2+ binding site [ion binding]; other site 1036743001284 G-X-G motif; other site 1036743001285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743001286 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1036743001287 substrate binding pocket [chemical binding]; other site 1036743001288 membrane-bound complex binding site; other site 1036743001289 hinge residues; other site 1036743001290 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1036743001291 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1036743001292 Metal-binding active site; metal-binding site 1036743001293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743001294 putative CheW interface [polypeptide binding]; other site 1036743001295 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743001296 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743001297 LabA_like proteins; Region: LabA_like; cd06167 1036743001298 putative metal binding site [ion binding]; other site 1036743001299 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1036743001300 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1036743001301 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1036743001302 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1036743001303 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1036743001304 active site 1036743001305 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1036743001306 AMMECR1; Region: AMMECR1; pfam01871 1036743001307 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1036743001308 putative ligand binding pocket/active site [active] 1036743001309 putative metal binding site [ion binding]; other site 1036743001310 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1036743001311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743001312 FeS/SAM binding site; other site 1036743001313 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1036743001314 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1036743001315 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 1036743001316 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1036743001317 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1036743001318 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1036743001319 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1036743001320 interface (dimer of trimers) [polypeptide binding]; other site 1036743001321 Substrate-binding/catalytic site; other site 1036743001322 Zn-binding sites [ion binding]; other site 1036743001323 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1036743001324 nudix motif; other site 1036743001325 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1036743001326 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1036743001327 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1036743001328 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1036743001329 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1036743001330 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1036743001331 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1036743001332 transcriptional regulator; Provisional; Region: PRK10632 1036743001333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743001334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743001335 dimerization interface [polypeptide binding]; other site 1036743001336 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1036743001337 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1036743001338 NAD(P) binding site [chemical binding]; other site 1036743001339 catalytic residues [active] 1036743001340 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1036743001341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1036743001342 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743001343 catalytic residue [active] 1036743001344 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1036743001345 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1036743001346 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1036743001347 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1036743001348 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1036743001349 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1036743001350 PYR/PP interface [polypeptide binding]; other site 1036743001351 dimer interface [polypeptide binding]; other site 1036743001352 TPP binding site [chemical binding]; other site 1036743001353 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1036743001354 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1036743001355 TPP-binding site [chemical binding]; other site 1036743001356 dimer interface [polypeptide binding]; other site 1036743001357 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1036743001358 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1036743001359 putative valine binding site [chemical binding]; other site 1036743001360 dimer interface [polypeptide binding]; other site 1036743001361 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1036743001362 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1036743001363 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1036743001364 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1036743001365 rod shape-determining protein MreB; Provisional; Region: PRK13927 1036743001366 MreB and similar proteins; Region: MreB_like; cd10225 1036743001367 nucleotide binding site [chemical binding]; other site 1036743001368 Mg binding site [ion binding]; other site 1036743001369 putative protofilament interaction site [polypeptide binding]; other site 1036743001370 RodZ interaction site [polypeptide binding]; other site 1036743001371 rod shape-determining protein MreC; Provisional; Region: PRK13922 1036743001372 rod shape-determining protein MreC; Region: MreC; pfam04085 1036743001373 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1036743001374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1036743001375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1036743001376 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1036743001377 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1036743001378 NAD(P) binding site [chemical binding]; other site 1036743001379 substrate binding site [chemical binding]; other site 1036743001380 dimer interface [polypeptide binding]; other site 1036743001381 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1036743001382 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1036743001383 FMN binding site [chemical binding]; other site 1036743001384 active site 1036743001385 substrate binding site [chemical binding]; other site 1036743001386 catalytic residue [active] 1036743001387 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1036743001388 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 1036743001389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743001390 FeS/SAM binding site; other site 1036743001391 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1036743001392 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1036743001393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743001394 FeS/SAM binding site; other site 1036743001395 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1036743001396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1036743001397 Predicted integral membrane protein [Function unknown]; Region: COG0392 1036743001398 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 1036743001399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743001400 Walker A motif; other site 1036743001401 ATP binding site [chemical binding]; other site 1036743001402 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 1036743001403 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 1036743001404 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1036743001405 metal ion-dependent adhesion site (MIDAS); other site 1036743001406 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 1036743001407 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1036743001408 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743001409 N-terminal plug; other site 1036743001410 ligand-binding site [chemical binding]; other site 1036743001411 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1036743001412 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1036743001413 intersubunit interface [polypeptide binding]; other site 1036743001414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1036743001415 putative PBP binding regions; other site 1036743001416 ABC-ATPase subunit interface; other site 1036743001417 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1036743001418 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1036743001419 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1036743001420 phytoene desaturase; Region: crtI_fam; TIGR02734 1036743001421 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1036743001422 active site lid residues [active] 1036743001423 substrate binding pocket [chemical binding]; other site 1036743001424 catalytic residues [active] 1036743001425 substrate-Mg2+ binding site; other site 1036743001426 aspartate-rich region 1; other site 1036743001427 aspartate-rich region 2; other site 1036743001428 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743001429 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743001430 ligand binding site [chemical binding]; other site 1036743001431 flexible hinge region; other site 1036743001432 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1036743001433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743001434 Walker A/P-loop; other site 1036743001435 ATP binding site [chemical binding]; other site 1036743001436 Q-loop/lid; other site 1036743001437 ABC transporter signature motif; other site 1036743001438 Walker B; other site 1036743001439 D-loop; other site 1036743001440 H-loop/switch region; other site 1036743001441 TOBE domain; Region: TOBE_2; pfam08402 1036743001442 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743001443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743001444 dimer interface [polypeptide binding]; other site 1036743001445 conserved gate region; other site 1036743001446 putative PBP binding loops; other site 1036743001447 ABC-ATPase subunit interface; other site 1036743001448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743001449 dimer interface [polypeptide binding]; other site 1036743001450 putative PBP binding loops; other site 1036743001451 ABC-ATPase subunit interface; other site 1036743001452 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1036743001453 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1036743001454 AAA domain; Region: AAA_23; pfam13476 1036743001455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743001456 Walker A/P-loop; other site 1036743001457 ATP binding site [chemical binding]; other site 1036743001458 SOS regulatory protein LexA; Region: lexA; TIGR00498 1036743001459 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1036743001460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1036743001461 active site 1036743001462 nucleotide binding site [chemical binding]; other site 1036743001463 HIGH motif; other site 1036743001464 KMSKS motif; other site 1036743001465 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1036743001466 Peptidase family M23; Region: Peptidase_M23; pfam01551 1036743001467 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1036743001468 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1036743001469 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1036743001470 active site 1036743001471 catalytic site [active] 1036743001472 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1036743001473 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1036743001474 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1036743001475 catalytic site [active] 1036743001476 active site 1036743001477 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1036743001478 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1036743001479 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1036743001480 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1036743001481 active site 1036743001482 catalytic site [active] 1036743001483 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1036743001484 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1036743001485 homodimer interface [polypeptide binding]; other site 1036743001486 substrate-cofactor binding pocket; other site 1036743001487 catalytic residue [active] 1036743001488 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1036743001489 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 1036743001490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743001491 ATP binding site [chemical binding]; other site 1036743001492 putative Mg++ binding site [ion binding]; other site 1036743001493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743001494 nucleotide binding region [chemical binding]; other site 1036743001495 ATP-binding site [chemical binding]; other site 1036743001496 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1036743001497 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1036743001498 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1036743001499 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1036743001500 quinone interaction residues [chemical binding]; other site 1036743001501 active site 1036743001502 catalytic residues [active] 1036743001503 FMN binding site [chemical binding]; other site 1036743001504 substrate binding site [chemical binding]; other site 1036743001505 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1036743001506 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1036743001507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743001508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1036743001509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743001510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1036743001511 Coenzyme A binding pocket [chemical binding]; other site 1036743001512 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1036743001513 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1036743001514 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1036743001515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743001516 FeS/SAM binding site; other site 1036743001517 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1036743001518 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 1036743001519 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 1036743001520 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1036743001521 putative binding surface; other site 1036743001522 active site 1036743001523 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1036743001524 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1036743001525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743001526 ATP binding site [chemical binding]; other site 1036743001527 Mg2+ binding site [ion binding]; other site 1036743001528 G-X-G motif; other site 1036743001529 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1036743001530 CheW-like domain; Region: CheW; pfam01584 1036743001531 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743001532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001533 active site 1036743001534 phosphorylation site [posttranslational modification] 1036743001535 intermolecular recognition site; other site 1036743001536 dimerization interface [polypeptide binding]; other site 1036743001537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001538 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743001539 active site 1036743001540 phosphorylation site [posttranslational modification] 1036743001541 intermolecular recognition site; other site 1036743001542 dimerization interface [polypeptide binding]; other site 1036743001543 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1036743001544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001545 active site 1036743001546 phosphorylation site [posttranslational modification] 1036743001547 intermolecular recognition site; other site 1036743001548 dimerization interface [polypeptide binding]; other site 1036743001549 CheB methylesterase; Region: CheB_methylest; pfam01339 1036743001550 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1036743001551 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1036743001552 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1036743001553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743001554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001555 active site 1036743001556 phosphorylation site [posttranslational modification] 1036743001557 intermolecular recognition site; other site 1036743001558 dimerization interface [polypeptide binding]; other site 1036743001559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743001560 DNA binding site [nucleotide binding] 1036743001561 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 1036743001562 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1036743001563 Walker A motif/ATP binding site; other site 1036743001564 Walker B motif; other site 1036743001565 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1036743001566 HSP70 interaction site [polypeptide binding]; other site 1036743001567 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1036743001568 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1036743001569 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1036743001570 FAD binding pocket [chemical binding]; other site 1036743001571 FAD binding motif [chemical binding]; other site 1036743001572 phosphate binding motif [ion binding]; other site 1036743001573 beta-alpha-beta structure motif; other site 1036743001574 NAD binding pocket [chemical binding]; other site 1036743001575 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1036743001576 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1036743001577 P-loop; other site 1036743001578 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1036743001579 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743001580 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1036743001581 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1036743001582 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1036743001583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743001584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743001585 Domain of unknown function (DUF955); Region: DUF955; cl01076 1036743001586 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1036743001587 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1036743001588 FHIPEP family; Region: FHIPEP; pfam00771 1036743001589 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1036743001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001591 active site 1036743001592 phosphorylation site [posttranslational modification] 1036743001593 intermolecular recognition site; other site 1036743001594 dimerization interface [polypeptide binding]; other site 1036743001595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743001596 Walker A motif; other site 1036743001597 ATP binding site [chemical binding]; other site 1036743001598 Walker B motif; other site 1036743001599 arginine finger; other site 1036743001600 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743001601 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1036743001602 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1036743001603 flagellar motor switch protein; Reviewed; Region: PRK08916 1036743001604 flagellar assembly protein H; Validated; Region: fliH; PRK06032 1036743001605 Flagellar assembly protein FliH; Region: FliH; pfam02108 1036743001606 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1036743001607 MgtE intracellular N domain; Region: MgtE_N; cl15244 1036743001608 FliG C-terminal domain; Region: FliG_C; pfam01706 1036743001609 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1036743001610 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1036743001611 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1036743001612 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1036743001613 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1036743001614 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1036743001615 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1036743001616 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1036743001617 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1036743001618 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1036743001619 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1036743001620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743001621 binding surface 1036743001622 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1036743001623 TPR motif; other site 1036743001624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743001625 TPR motif; other site 1036743001626 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1036743001627 binding surface 1036743001628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743001629 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1036743001630 Coenzyme A binding pocket [chemical binding]; other site 1036743001631 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743001632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1036743001633 active site 1036743001634 phosphorylation site [posttranslational modification] 1036743001635 intermolecular recognition site; other site 1036743001636 dimerization interface [polypeptide binding]; other site 1036743001637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743001638 dimer interface [polypeptide binding]; other site 1036743001639 phosphorylation site [posttranslational modification] 1036743001640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743001641 ATP binding site [chemical binding]; other site 1036743001642 Mg2+ binding site [ion binding]; other site 1036743001643 G-X-G motif; other site 1036743001644 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1036743001645 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1036743001646 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1036743001647 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1036743001648 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1036743001649 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1036743001650 putative active site [active] 1036743001651 putative substrate binding site [chemical binding]; other site 1036743001652 putative cosubstrate binding site; other site 1036743001653 catalytic site [active] 1036743001654 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1036743001655 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1036743001656 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1036743001657 homodimer interface [polypeptide binding]; other site 1036743001658 NADP binding site [chemical binding]; other site 1036743001659 substrate binding site [chemical binding]; other site 1036743001660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1036743001661 PAS domain; Region: PAS_9; pfam13426 1036743001662 putative active site [active] 1036743001663 heme pocket [chemical binding]; other site 1036743001664 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743001665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743001666 metal binding site [ion binding]; metal-binding site 1036743001667 active site 1036743001668 I-site; other site 1036743001669 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743001670 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743001671 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1036743001672 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1036743001673 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1036743001674 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1036743001675 Trypsin; Region: Trypsin; pfam00089 1036743001676 active site 1036743001677 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 1036743001678 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1036743001679 putative ligand binding site [chemical binding]; other site 1036743001680 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 1036743001681 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 1036743001682 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1036743001683 FAD binding pocket [chemical binding]; other site 1036743001684 FAD binding motif [chemical binding]; other site 1036743001685 phosphate binding motif [ion binding]; other site 1036743001686 beta-alpha-beta structure motif; other site 1036743001687 NAD binding pocket [chemical binding]; other site 1036743001688 Iron coordination center [ion binding]; other site 1036743001689 protease TldD; Provisional; Region: tldD; PRK10735 1036743001690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743001691 dimerization interface [polypeptide binding]; other site 1036743001692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743001693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743001694 dimer interface [polypeptide binding]; other site 1036743001695 putative CheW interface [polypeptide binding]; other site 1036743001696 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 1036743001697 glutamate--cysteine ligase; Region: PLN02611 1036743001698 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1036743001699 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1036743001700 UbiA prenyltransferase family; Region: UbiA; pfam01040 1036743001701 Predicted methyltransferase [General function prediction only]; Region: COG3897 1036743001702 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1036743001703 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1036743001704 Cache domain; Region: Cache_1; pfam02743 1036743001705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743001706 dimerization interface [polypeptide binding]; other site 1036743001707 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743001708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743001709 dimer interface [polypeptide binding]; other site 1036743001710 putative CheW interface [polypeptide binding]; other site 1036743001711 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1036743001712 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1036743001713 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1036743001714 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1036743001715 putative active site [active] 1036743001716 putative metal binding site [ion binding]; other site 1036743001717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743001718 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1036743001719 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1036743001720 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1036743001721 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1036743001722 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1036743001723 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1036743001724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743001725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1036743001726 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743001727 TM-ABC transporter signature motif; other site 1036743001728 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1036743001729 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1036743001730 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1036743001731 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1036743001732 Walker A/P-loop; other site 1036743001733 ATP binding site [chemical binding]; other site 1036743001734 Q-loop/lid; other site 1036743001735 ABC transporter signature motif; other site 1036743001736 Walker B; other site 1036743001737 D-loop; other site 1036743001738 H-loop/switch region; other site 1036743001739 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1036743001740 oligomerisation interface [polypeptide binding]; other site 1036743001741 mobile loop; other site 1036743001742 roof hairpin; other site 1036743001743 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1036743001744 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1036743001745 ring oligomerisation interface [polypeptide binding]; other site 1036743001746 ATP/Mg binding site [chemical binding]; other site 1036743001747 stacking interactions; other site 1036743001748 hinge regions; other site 1036743001749 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1036743001750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743001751 Walker A/P-loop; other site 1036743001752 ATP binding site [chemical binding]; other site 1036743001753 Q-loop/lid; other site 1036743001754 ABC transporter signature motif; other site 1036743001755 Walker B; other site 1036743001756 D-loop; other site 1036743001757 H-loop/switch region; other site 1036743001758 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1036743001759 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1036743001760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743001761 Walker A/P-loop; other site 1036743001762 ATP binding site [chemical binding]; other site 1036743001763 Q-loop/lid; other site 1036743001764 ABC transporter signature motif; other site 1036743001765 Walker B; other site 1036743001766 D-loop; other site 1036743001767 H-loop/switch region; other site 1036743001768 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743001769 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1036743001770 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1036743001771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743001772 dimer interface [polypeptide binding]; other site 1036743001773 conserved gate region; other site 1036743001774 putative PBP binding loops; other site 1036743001775 ABC-ATPase subunit interface; other site 1036743001776 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1036743001777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743001778 dimer interface [polypeptide binding]; other site 1036743001779 conserved gate region; other site 1036743001780 putative PBP binding loops; other site 1036743001781 ABC-ATPase subunit interface; other site 1036743001782 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1036743001783 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1036743001784 peptide binding site [polypeptide binding]; other site 1036743001785 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1036743001786 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1036743001787 Moco binding site; other site 1036743001788 metal coordination site [ion binding]; other site 1036743001789 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1036743001790 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1036743001791 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1036743001792 TPP-binding site [chemical binding]; other site 1036743001793 dimer interface [polypeptide binding]; other site 1036743001794 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1036743001795 PYR/PP interface [polypeptide binding]; other site 1036743001796 dimer interface [polypeptide binding]; other site 1036743001797 TPP binding site [chemical binding]; other site 1036743001798 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1036743001799 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1036743001800 intersubunit interface [polypeptide binding]; other site 1036743001801 active site 1036743001802 zinc binding site [ion binding]; other site 1036743001803 Na+ binding site [ion binding]; other site 1036743001804 Abi-like protein; Region: Abi_2; pfam07751 1036743001805 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1036743001806 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1036743001807 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1036743001808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743001809 dimer interface [polypeptide binding]; other site 1036743001810 conserved gate region; other site 1036743001811 putative PBP binding loops; other site 1036743001812 ABC-ATPase subunit interface; other site 1036743001813 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1036743001814 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1036743001815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743001816 dimer interface [polypeptide binding]; other site 1036743001817 conserved gate region; other site 1036743001818 putative PBP binding loops; other site 1036743001819 ABC-ATPase subunit interface; other site 1036743001820 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1036743001821 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1036743001822 Walker A/P-loop; other site 1036743001823 ATP binding site [chemical binding]; other site 1036743001824 Q-loop/lid; other site 1036743001825 ABC transporter signature motif; other site 1036743001826 Walker B; other site 1036743001827 D-loop; other site 1036743001828 H-loop/switch region; other site 1036743001829 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1036743001830 PhoU domain; Region: PhoU; pfam01895 1036743001831 PhoU domain; Region: PhoU; pfam01895 1036743001832 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1036743001833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743001834 active site 1036743001835 phosphorylation site [posttranslational modification] 1036743001836 intermolecular recognition site; other site 1036743001837 dimerization interface [polypeptide binding]; other site 1036743001838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743001839 DNA binding site [nucleotide binding] 1036743001840 Predicted membrane protein [Function unknown]; Region: COG2855 1036743001841 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1036743001842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743001843 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1036743001844 putative dimerization interface [polypeptide binding]; other site 1036743001845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743001846 active site 1036743001847 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1036743001848 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1036743001849 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1036743001850 Ligand Binding Site [chemical binding]; other site 1036743001851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 1036743001852 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1036743001853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743001854 PAS domain; Region: PAS_9; pfam13426 1036743001855 putative active site [active] 1036743001856 heme pocket [chemical binding]; other site 1036743001857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743001858 PAS domain; Region: PAS_9; pfam13426 1036743001859 putative active site [active] 1036743001860 heme pocket [chemical binding]; other site 1036743001861 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743001862 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743001863 metal binding site [ion binding]; metal-binding site 1036743001864 active site 1036743001865 I-site; other site 1036743001866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743001867 V4R domain; Region: V4R; cl15268 1036743001868 putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055 1036743001869 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 1036743001870 Bacterial PH domain; Region: DUF304; pfam03703 1036743001871 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cd00226 1036743001872 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 1036743001873 subunit C interaction residues; other site 1036743001874 subunit M interaction residues [polypeptide binding]; other site 1036743001875 subunit L interaction residues [polypeptide binding]; other site 1036743001876 putative proton transfer pathway, P1; other site 1036743001877 putative proton transfer pathway, P2; other site 1036743001878 PUCC protein; Region: PUCC; pfam03209 1036743001879 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1036743001880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743001881 S-adenosylmethionine binding site [chemical binding]; other site 1036743001882 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1036743001883 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 1036743001884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743001885 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 1036743001886 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1036743001887 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 1036743001888 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1036743001889 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1036743001890 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 1036743001891 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1036743001892 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 1036743001893 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 1036743001894 PAS domain; Region: PAS; smart00091 1036743001895 putative active site [active] 1036743001896 heme pocket [chemical binding]; other site 1036743001897 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743001898 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 1036743001899 UbiA prenyltransferase family; Region: UbiA; pfam01040 1036743001900 PUCC protein; Region: PUCC; pfam03209 1036743001901 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 1036743001902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743001903 PAS fold; Region: PAS_3; pfam08447 1036743001904 putative active site [active] 1036743001905 heme pocket [chemical binding]; other site 1036743001906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743001907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743001908 metal binding site [ion binding]; metal-binding site 1036743001909 active site 1036743001910 I-site; other site 1036743001911 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743001912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743001913 dimerization interface [polypeptide binding]; other site 1036743001914 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743001915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743001916 dimer interface [polypeptide binding]; other site 1036743001917 putative CheW interface [polypeptide binding]; other site 1036743001918 Hemerythrin; Region: Hemerythrin; cd12107 1036743001919 Fe binding site [ion binding]; other site 1036743001920 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1036743001921 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1036743001922 active site 1036743001923 catalytic site [active] 1036743001924 substrate binding site [chemical binding]; other site 1036743001925 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1036743001926 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743001927 ligand binding site [chemical binding]; other site 1036743001928 flexible hinge region; other site 1036743001929 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 1036743001930 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1036743001931 metal binding triad; other site 1036743001932 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1036743001933 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1036743001934 Na binding site [ion binding]; other site 1036743001935 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1036743001936 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 1036743001937 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1036743001938 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1036743001939 catalytic residue [active] 1036743001940 RecX family; Region: RecX; pfam02631 1036743001941 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1036743001942 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1036743001943 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1036743001944 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1036743001945 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1036743001946 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1036743001947 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1036743001948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743001949 active site 1036743001950 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1036743001951 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1036743001952 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1036743001953 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1036743001954 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1036743001955 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1036743001956 tetramer interface [polypeptide binding]; other site 1036743001957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743001958 catalytic residue [active] 1036743001959 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1036743001960 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1036743001961 nucleoside/Zn binding site; other site 1036743001962 dimer interface [polypeptide binding]; other site 1036743001963 catalytic motif [active] 1036743001964 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1036743001965 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1036743001966 catalytic triad [active] 1036743001967 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1036743001968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1036743001969 RNA binding surface [nucleotide binding]; other site 1036743001970 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1036743001971 active site 1036743001972 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1036743001973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743001974 S-adenosylmethionine binding site [chemical binding]; other site 1036743001975 inner membrane protein; Provisional; Region: PRK10995 1036743001976 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1036743001977 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743001978 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1036743001979 Proline dehydrogenase; Region: Pro_dh; pfam01619 1036743001980 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1036743001981 Glutamate binding site [chemical binding]; other site 1036743001982 NAD binding site [chemical binding]; other site 1036743001983 catalytic residues [active] 1036743001984 Lysine efflux permease [General function prediction only]; Region: COG1279 1036743001985 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1036743001986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743001987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743001988 dimerization interface [polypeptide binding]; other site 1036743001989 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743001990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1036743001991 active site 1036743001992 phosphorylation site [posttranslational modification] 1036743001993 intermolecular recognition site; other site 1036743001994 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1036743001995 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743001996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743001997 metal binding site [ion binding]; metal-binding site 1036743001998 active site 1036743001999 I-site; other site 1036743002000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743002001 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1036743002002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743002003 ATP binding site [chemical binding]; other site 1036743002004 Mg2+ binding site [ion binding]; other site 1036743002005 G-X-G motif; other site 1036743002006 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1036743002007 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1036743002008 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1036743002009 rRNA binding site [nucleotide binding]; other site 1036743002010 predicted 30S ribosome binding site; other site 1036743002011 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743002012 DNA-binding site [nucleotide binding]; DNA binding site 1036743002013 RNA-binding motif; other site 1036743002014 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743002016 active site 1036743002017 phosphorylation site [posttranslational modification] 1036743002018 intermolecular recognition site; other site 1036743002019 dimerization interface [polypeptide binding]; other site 1036743002020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1036743002021 Histidine kinase; Region: HisKA_2; pfam07568 1036743002022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743002023 ATP binding site [chemical binding]; other site 1036743002024 Mg2+ binding site [ion binding]; other site 1036743002025 G-X-G motif; other site 1036743002026 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743002027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743002028 active site 1036743002029 phosphorylation site [posttranslational modification] 1036743002030 intermolecular recognition site; other site 1036743002031 dimerization interface [polypeptide binding]; other site 1036743002032 CHASE3 domain; Region: CHASE3; pfam05227 1036743002033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743002034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743002035 dimer interface [polypeptide binding]; other site 1036743002036 phosphorylation site [posttranslational modification] 1036743002037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743002038 ATP binding site [chemical binding]; other site 1036743002039 Mg2+ binding site [ion binding]; other site 1036743002040 G-X-G motif; other site 1036743002041 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1036743002042 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1036743002043 putative dimer interface [polypeptide binding]; other site 1036743002044 active site pocket [active] 1036743002045 putative cataytic base [active] 1036743002046 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1036743002047 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1036743002048 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1036743002049 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1036743002050 homotrimer interface [polypeptide binding]; other site 1036743002051 Walker A motif; other site 1036743002052 GTP binding site [chemical binding]; other site 1036743002053 Walker B motif; other site 1036743002054 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1036743002055 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1036743002056 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1036743002057 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1036743002058 active site 1036743002059 DNA binding site [nucleotide binding] 1036743002060 Int/Topo IB signature motif; other site 1036743002061 Restriction endonuclease; Region: Mrr_cat; pfam04471 1036743002062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1036743002063 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1036743002064 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1036743002065 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293 1036743002066 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1036743002067 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1036743002068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743002069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743002070 glutathione reductase; Validated; Region: PRK06116 1036743002071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1036743002072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743002073 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1036743002074 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1036743002075 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 1036743002076 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1036743002077 active site 1036743002078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743002079 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1036743002080 putative dimerization interface [polypeptide binding]; other site 1036743002081 NAD synthetase; Provisional; Region: PRK13981 1036743002082 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1036743002083 multimer interface [polypeptide binding]; other site 1036743002084 active site 1036743002085 catalytic triad [active] 1036743002086 protein interface 1 [polypeptide binding]; other site 1036743002087 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1036743002088 homodimer interface [polypeptide binding]; other site 1036743002089 NAD binding pocket [chemical binding]; other site 1036743002090 ATP binding pocket [chemical binding]; other site 1036743002091 Mg binding site [ion binding]; other site 1036743002092 active-site loop [active] 1036743002093 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 1036743002094 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1036743002095 active site 1036743002096 HIGH motif; other site 1036743002097 nucleotide binding site [chemical binding]; other site 1036743002098 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1036743002099 active site 1036743002100 KMSKS motif; other site 1036743002101 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1036743002102 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1036743002103 active site 1036743002104 HIGH motif; other site 1036743002105 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1036743002106 KMSKS motif; other site 1036743002107 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1036743002108 tRNA binding surface [nucleotide binding]; other site 1036743002109 anticodon binding site; other site 1036743002110 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1036743002111 FIST N domain; Region: FIST; smart00897 1036743002112 FIST C domain; Region: FIST_C; pfam10442 1036743002113 PAS fold; Region: PAS_7; pfam12860 1036743002114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743002115 PAS domain; Region: PAS_9; pfam13426 1036743002116 putative active site [active] 1036743002117 heme pocket [chemical binding]; other site 1036743002118 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1036743002119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743002120 ATP binding site [chemical binding]; other site 1036743002121 Mg2+ binding site [ion binding]; other site 1036743002122 G-X-G motif; other site 1036743002123 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743002124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743002125 active site 1036743002126 phosphorylation site [posttranslational modification] 1036743002127 intermolecular recognition site; other site 1036743002128 dimerization interface [polypeptide binding]; other site 1036743002129 HDOD domain; Region: HDOD; pfam08668 1036743002130 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743002131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743002132 active site 1036743002133 phosphorylation site [posttranslational modification] 1036743002134 intermolecular recognition site; other site 1036743002135 dimerization interface [polypeptide binding]; other site 1036743002136 HD domain; Region: HD_5; pfam13487 1036743002137 GAF domain; Region: GAF; pfam01590 1036743002138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1036743002139 Histidine kinase; Region: HisKA_2; pfam07568 1036743002140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743002141 ATP binding site [chemical binding]; other site 1036743002142 Mg2+ binding site [ion binding]; other site 1036743002143 G-X-G motif; other site 1036743002144 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743002145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743002146 active site 1036743002147 phosphorylation site [posttranslational modification] 1036743002148 intermolecular recognition site; other site 1036743002149 dimerization interface [polypeptide binding]; other site 1036743002150 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1036743002151 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1036743002152 active site 1036743002153 catalytic residues [active] 1036743002154 metal binding site [ion binding]; metal-binding site 1036743002155 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1036743002156 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1036743002157 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1036743002158 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1036743002159 cation binding site [ion binding]; other site 1036743002160 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1036743002161 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1036743002162 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1036743002163 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1036743002164 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1036743002165 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1036743002166 RNA binding surface [nucleotide binding]; other site 1036743002167 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1036743002168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002169 Walker A/P-loop; other site 1036743002170 ATP binding site [chemical binding]; other site 1036743002171 Q-loop/lid; other site 1036743002172 ABC transporter signature motif; other site 1036743002173 Walker B; other site 1036743002174 D-loop; other site 1036743002175 H-loop/switch region; other site 1036743002176 TOBE domain; Region: TOBE; cl01440 1036743002177 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1036743002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002179 dimer interface [polypeptide binding]; other site 1036743002180 conserved gate region; other site 1036743002181 putative PBP binding loops; other site 1036743002182 ABC-ATPase subunit interface; other site 1036743002183 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1036743002184 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1036743002185 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1036743002186 putative GSH binding site [chemical binding]; other site 1036743002187 catalytic residues [active] 1036743002188 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1036743002189 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1036743002190 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1036743002191 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1036743002192 dimerization interface [polypeptide binding]; other site 1036743002193 ATP binding site [chemical binding]; other site 1036743002194 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1036743002195 dimerization interface [polypeptide binding]; other site 1036743002196 ATP binding site [chemical binding]; other site 1036743002197 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1036743002198 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1036743002199 putative active site [active] 1036743002200 catalytic triad [active] 1036743002201 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1036743002202 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1036743002203 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1036743002204 ATP binding site [chemical binding]; other site 1036743002205 active site 1036743002206 substrate binding site [chemical binding]; other site 1036743002207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743002208 non-specific DNA binding site [nucleotide binding]; other site 1036743002209 salt bridge; other site 1036743002210 sequence-specific DNA binding site [nucleotide binding]; other site 1036743002211 NRDE protein; Region: NRDE; cl01315 1036743002212 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 1036743002213 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1036743002214 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1036743002215 Cl binding site [ion binding]; other site 1036743002216 oligomer interface [polypeptide binding]; other site 1036743002217 adenylosuccinate lyase; Provisional; Region: PRK07492 1036743002218 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1036743002219 tetramer interface [polypeptide binding]; other site 1036743002220 active site 1036743002221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743002222 non-specific DNA binding site [nucleotide binding]; other site 1036743002223 salt bridge; other site 1036743002224 sequence-specific DNA binding site [nucleotide binding]; other site 1036743002225 Predicted transcriptional regulator [Transcription]; Region: COG2932 1036743002226 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1036743002227 Catalytic site [active] 1036743002228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743002229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743002230 dimer interface [polypeptide binding]; other site 1036743002231 putative CheW interface [polypeptide binding]; other site 1036743002232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743002233 substrate binding pocket [chemical binding]; other site 1036743002234 membrane-bound complex binding site; other site 1036743002235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1036743002236 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1036743002237 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1036743002238 Putative zinc-finger; Region: zf-HC2; pfam13490 1036743002239 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1036743002240 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1036743002241 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743002242 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743002243 DNA binding residues [nucleotide binding] 1036743002244 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1036743002245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1036743002246 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1036743002247 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1036743002248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743002249 S-adenosylmethionine binding site [chemical binding]; other site 1036743002250 MFS/sugar transport protein; Region: MFS_2; pfam13347 1036743002251 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1036743002252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743002253 putative substrate translocation pore; other site 1036743002254 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1036743002255 SnoaL-like domain; Region: SnoaL_2; pfam12680 1036743002256 short chain dehydrogenase; Provisional; Region: PRK07024 1036743002257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743002258 NAD(P) binding site [chemical binding]; other site 1036743002259 active site 1036743002260 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1036743002261 hypothetical protein; Reviewed; Region: PRK00024 1036743002262 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1036743002263 MPN+ (JAMM) motif; other site 1036743002264 Zinc-binding site [ion binding]; other site 1036743002265 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1036743002266 active site 1036743002267 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1036743002268 subunit interaction site [polypeptide binding]; other site 1036743002269 PHB binding site; other site 1036743002270 CoenzymeA binding site [chemical binding]; other site 1036743002271 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1036743002272 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1036743002273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743002274 S-adenosylmethionine binding site [chemical binding]; other site 1036743002275 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1036743002276 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1036743002277 GSH binding site [chemical binding]; other site 1036743002278 catalytic residues [active] 1036743002279 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1036743002280 nitrilase; Region: PLN02798 1036743002281 putative active site [active] 1036743002282 catalytic triad [active] 1036743002283 dimer interface [polypeptide binding]; other site 1036743002284 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 1036743002285 PAS fold; Region: PAS_4; pfam08448 1036743002286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1036743002287 HWE histidine kinase; Region: HWE_HK; smart00911 1036743002288 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1036743002289 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1036743002290 aspartate kinase; Reviewed; Region: PRK06635 1036743002291 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1036743002292 putative nucleotide binding site [chemical binding]; other site 1036743002293 putative catalytic residues [active] 1036743002294 putative Mg ion binding site [ion binding]; other site 1036743002295 putative aspartate binding site [chemical binding]; other site 1036743002296 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1036743002297 putative allosteric regulatory site; other site 1036743002298 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1036743002299 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1036743002300 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1036743002301 FMN binding site [chemical binding]; other site 1036743002302 substrate binding site [chemical binding]; other site 1036743002303 putative catalytic residue [active] 1036743002304 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1036743002305 GAF domain; Region: GAF; pfam01590 1036743002306 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1036743002307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1036743002308 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1036743002309 Helix-turn-helix domain; Region: HTH_25; pfam13413 1036743002310 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1036743002311 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1036743002312 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1036743002313 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1036743002314 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1036743002315 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1036743002316 dimer interface [polypeptide binding]; other site 1036743002317 motif 1; other site 1036743002318 active site 1036743002319 motif 2; other site 1036743002320 motif 3; other site 1036743002321 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1036743002322 anticodon binding site; other site 1036743002323 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1036743002324 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1036743002325 tRNA; other site 1036743002326 putative tRNA binding site [nucleotide binding]; other site 1036743002327 putative NADP binding site [chemical binding]; other site 1036743002328 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1036743002329 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1036743002330 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1036743002331 RF-1 domain; Region: RF-1; pfam00472 1036743002332 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1036743002333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743002334 S-adenosylmethionine binding site [chemical binding]; other site 1036743002335 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1036743002336 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1036743002337 Clp amino terminal domain; Region: Clp_N; pfam02861 1036743002338 Clp amino terminal domain; Region: Clp_N; pfam02861 1036743002339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743002340 Walker A motif; other site 1036743002341 ATP binding site [chemical binding]; other site 1036743002342 Walker B motif; other site 1036743002343 arginine finger; other site 1036743002344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743002345 Walker A motif; other site 1036743002346 ATP binding site [chemical binding]; other site 1036743002347 Walker B motif; other site 1036743002348 arginine finger; other site 1036743002349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1036743002350 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743002351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743002352 dimerization interface [polypeptide binding]; other site 1036743002353 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743002354 dimer interface [polypeptide binding]; other site 1036743002355 putative CheW interface [polypeptide binding]; other site 1036743002356 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1036743002357 Domain of unknown function DUF21; Region: DUF21; pfam01595 1036743002358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1036743002359 Transporter associated domain; Region: CorC_HlyC; smart01091 1036743002360 Isochorismatase family; Region: Isochorismatase; pfam00857 1036743002361 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1036743002362 catalytic triad [active] 1036743002363 conserved cis-peptide bond; other site 1036743002364 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1036743002365 conserved cys residue [active] 1036743002366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002367 Helix-turn-helix domain; Region: HTH_18; pfam12833 1036743002368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1036743002369 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1036743002370 active site 1036743002371 catalytic tetrad [active] 1036743002372 large tegument protein UL36; Provisional; Region: PHA03247 1036743002373 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1036743002374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743002375 FeS/SAM binding site; other site 1036743002376 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1036743002377 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1036743002378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743002379 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1036743002380 FeS/SAM binding site; other site 1036743002381 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 1036743002382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743002383 FeS/SAM binding site; other site 1036743002384 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1036743002385 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1036743002386 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1036743002387 active site 1036743002388 purine riboside binding site [chemical binding]; other site 1036743002389 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1036743002390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002391 Walker A/P-loop; other site 1036743002392 ATP binding site [chemical binding]; other site 1036743002393 Q-loop/lid; other site 1036743002394 ABC transporter signature motif; other site 1036743002395 Walker B; other site 1036743002396 D-loop; other site 1036743002397 H-loop/switch region; other site 1036743002398 TOBE domain; Region: TOBE_2; pfam08402 1036743002399 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1036743002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002401 dimer interface [polypeptide binding]; other site 1036743002402 conserved gate region; other site 1036743002403 putative PBP binding loops; other site 1036743002404 ABC-ATPase subunit interface; other site 1036743002405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002406 dimer interface [polypeptide binding]; other site 1036743002407 conserved gate region; other site 1036743002408 putative PBP binding loops; other site 1036743002409 ABC-ATPase subunit interface; other site 1036743002410 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1036743002411 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1036743002412 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1036743002413 Peptidase family M23; Region: Peptidase_M23; pfam01551 1036743002414 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1036743002415 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1036743002416 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1036743002417 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1036743002418 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1036743002419 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1036743002420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1036743002421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743002422 catalytic residue [active] 1036743002423 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1036743002424 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1036743002425 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1036743002426 hypothetical protein; Provisional; Region: PRK08912 1036743002427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743002428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743002429 homodimer interface [polypeptide binding]; other site 1036743002430 catalytic residue [active] 1036743002431 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743002432 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743002433 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1036743002434 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1036743002435 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1036743002436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743002437 substrate binding pocket [chemical binding]; other site 1036743002438 membrane-bound complex binding site; other site 1036743002439 hinge residues; other site 1036743002440 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1036743002441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1036743002442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002443 putative PBP binding loops; other site 1036743002444 dimer interface [polypeptide binding]; other site 1036743002445 ABC-ATPase subunit interface; other site 1036743002446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002447 dimer interface [polypeptide binding]; other site 1036743002448 conserved gate region; other site 1036743002449 putative PBP binding loops; other site 1036743002450 ABC-ATPase subunit interface; other site 1036743002451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1036743002452 non-specific DNA binding site [nucleotide binding]; other site 1036743002453 salt bridge; other site 1036743002454 sequence-specific DNA binding site [nucleotide binding]; other site 1036743002455 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1036743002456 RES domain; Region: RES; pfam08808 1036743002457 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1036743002458 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1036743002459 homodimer interface [polypeptide binding]; other site 1036743002460 substrate-cofactor binding pocket; other site 1036743002461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743002462 catalytic residue [active] 1036743002463 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1036743002464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743002465 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1036743002466 substrate binding pocket [chemical binding]; other site 1036743002467 dimerization interface [polypeptide binding]; other site 1036743002468 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1036743002469 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1036743002470 homodimer interface [polypeptide binding]; other site 1036743002471 substrate-cofactor binding pocket; other site 1036743002472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743002473 catalytic residue [active] 1036743002474 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1036743002475 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1036743002476 dimer interface [polypeptide binding]; other site 1036743002477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743002478 catalytic residue [active] 1036743002479 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1036743002480 FOG: CBS domain [General function prediction only]; Region: COG0517 1036743002481 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1036743002482 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1036743002483 Walker A/P-loop; other site 1036743002484 ATP binding site [chemical binding]; other site 1036743002485 Q-loop/lid; other site 1036743002486 ABC transporter signature motif; other site 1036743002487 Walker B; other site 1036743002488 D-loop; other site 1036743002489 H-loop/switch region; other site 1036743002490 NIL domain; Region: NIL; pfam09383 1036743002491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002492 dimer interface [polypeptide binding]; other site 1036743002493 conserved gate region; other site 1036743002494 ABC-ATPase subunit interface; other site 1036743002495 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1036743002496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1036743002497 acyl-activating enzyme (AAE) consensus motif; other site 1036743002498 AMP binding site [chemical binding]; other site 1036743002499 active site 1036743002500 CoA binding site [chemical binding]; other site 1036743002501 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1036743002502 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1036743002503 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1036743002504 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 1036743002505 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1036743002506 trimer interface [polypeptide binding]; other site 1036743002507 active site 1036743002508 substrate binding site [chemical binding]; other site 1036743002509 CoA binding site [chemical binding]; other site 1036743002510 Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971 1036743002511 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1036743002512 Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972 1036743002513 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1036743002514 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1036743002515 nitrogenase iron protein; Region: nifH; TIGR01287 1036743002516 Nucleotide-binding sites [chemical binding]; other site 1036743002517 Walker A motif; other site 1036743002518 Switch I region of nucleotide binding site; other site 1036743002519 Fe4S4 binding sites [ion binding]; other site 1036743002520 Switch II region of nucleotide binding site; other site 1036743002521 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1036743002522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743002523 FeS/SAM binding site; other site 1036743002524 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1036743002525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743002526 putative substrate translocation pore; other site 1036743002527 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1036743002528 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743002529 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1036743002530 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1036743002531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002532 dimer interface [polypeptide binding]; other site 1036743002533 conserved gate region; other site 1036743002534 putative PBP binding loops; other site 1036743002535 ABC-ATPase subunit interface; other site 1036743002536 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1036743002537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743002538 dimer interface [polypeptide binding]; other site 1036743002539 conserved gate region; other site 1036743002540 putative PBP binding loops; other site 1036743002541 ABC-ATPase subunit interface; other site 1036743002542 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1036743002543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743002544 Walker A/P-loop; other site 1036743002545 ATP binding site [chemical binding]; other site 1036743002546 Q-loop/lid; other site 1036743002547 ABC transporter signature motif; other site 1036743002548 Walker B; other site 1036743002549 D-loop; other site 1036743002550 H-loop/switch region; other site 1036743002551 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1036743002552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743002553 Walker A/P-loop; other site 1036743002554 ATP binding site [chemical binding]; other site 1036743002555 Q-loop/lid; other site 1036743002556 ABC transporter signature motif; other site 1036743002557 Walker B; other site 1036743002558 D-loop; other site 1036743002559 H-loop/switch region; other site 1036743002560 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1036743002561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743002562 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1036743002563 dimerization interface [polypeptide binding]; other site 1036743002564 substrate binding pocket [chemical binding]; other site 1036743002565 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 1036743002566 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1036743002567 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1036743002568 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1036743002569 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1036743002570 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743002571 Walker A motif; other site 1036743002572 ATP binding site [chemical binding]; other site 1036743002573 Walker B motif; other site 1036743002574 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1036743002575 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 1036743002576 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1036743002577 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743002578 Walker B motif; other site 1036743002579 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743002580 Walker A motif; other site 1036743002581 ATP binding site [chemical binding]; other site 1036743002582 RES domain; Region: RES; smart00953 1036743002583 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1036743002584 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 1036743002585 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1036743002586 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1036743002587 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1036743002588 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743002589 active site 1036743002590 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743002591 Ligand Binding Site [chemical binding]; other site 1036743002592 Molecular Tunnel; other site 1036743002593 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1036743002594 Hpr binding site; other site 1036743002595 active site 1036743002596 homohexamer subunit interaction site [polypeptide binding]; other site 1036743002597 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1036743002598 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1036743002599 Cupin superfamily protein; Region: Cupin_4; pfam08007 1036743002600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1036743002601 MULE transposase domain; Region: MULE; pfam10551 1036743002602 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1036743002603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002604 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1036743002605 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1036743002606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1036743002607 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1036743002608 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 1036743002609 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1036743002610 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1036743002611 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1036743002612 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1036743002613 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1036743002614 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002615 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002617 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002619 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1036743002621 Leucine rich repeat; Region: LRR_8; pfam13855 1036743002622 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1036743002623 Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914 1036743002624 G1 box; other site 1036743002625 GTP/Mg2+ binding site [chemical binding]; other site 1036743002626 G2 box; other site 1036743002627 Switch I region; other site 1036743002628 G3 box; other site 1036743002629 Switch II region; other site 1036743002630 G4 box; other site 1036743002631 G5 box; other site 1036743002632 TIR domain; Region: TIR_2; cl17458 1036743002633 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743002634 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743002635 N-terminal plug; other site 1036743002636 ligand-binding site [chemical binding]; other site 1036743002637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743002638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002639 muropeptide transporter; Validated; Region: ampG; cl17669 1036743002640 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1036743002641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743002642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743002644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002645 Walker A/P-loop; other site 1036743002646 ATP binding site [chemical binding]; other site 1036743002647 Q-loop/lid; other site 1036743002648 ABC transporter signature motif; other site 1036743002649 Walker B; other site 1036743002650 D-loop; other site 1036743002651 H-loop/switch region; other site 1036743002652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743002653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002654 Walker A/P-loop; other site 1036743002655 ATP binding site [chemical binding]; other site 1036743002656 Q-loop/lid; other site 1036743002657 ABC transporter signature motif; other site 1036743002658 Walker B; other site 1036743002659 D-loop; other site 1036743002660 H-loop/switch region; other site 1036743002661 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1036743002662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743002663 N-terminal plug; other site 1036743002664 ligand-binding site [chemical binding]; other site 1036743002665 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1036743002666 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1036743002667 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1036743002668 muropeptide transporter; Validated; Region: ampG; cl17669 1036743002669 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1036743002670 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1036743002671 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 1036743002672 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1036743002673 sulfotransferase; Region: PLN02164 1036743002674 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743002675 active site 1036743002676 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743002677 Ligand Binding Site [chemical binding]; other site 1036743002678 Molecular Tunnel; other site 1036743002679 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1036743002680 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1036743002681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743002682 putative substrate translocation pore; other site 1036743002683 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1036743002684 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743002685 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743002686 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1036743002687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1036743002688 MarR family; Region: MarR_2; pfam12802 1036743002689 MarR family; Region: MarR_2; cl17246 1036743002690 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743002691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743002693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002694 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1036743002695 Walker A/P-loop; other site 1036743002696 ATP binding site [chemical binding]; other site 1036743002697 Q-loop/lid; other site 1036743002698 ABC transporter signature motif; other site 1036743002699 Walker B; other site 1036743002700 D-loop; other site 1036743002701 H-loop/switch region; other site 1036743002702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743002703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1036743002705 Walker A/P-loop; other site 1036743002706 ATP binding site [chemical binding]; other site 1036743002707 Q-loop/lid; other site 1036743002708 ABC transporter signature motif; other site 1036743002709 Walker B; other site 1036743002710 D-loop; other site 1036743002711 H-loop/switch region; other site 1036743002712 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743002713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743002714 N-terminal plug; other site 1036743002715 ligand-binding site [chemical binding]; other site 1036743002716 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1036743002717 muropeptide transporter; Validated; Region: ampG; cl17669 1036743002718 Caspase domain; Region: Peptidase_C14; pfam00656 1036743002719 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1036743002720 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1036743002721 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1036743002722 structural tetrad; other site 1036743002723 Caspase domain; Region: Peptidase_C14; pfam00656 1036743002724 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1036743002725 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743002726 ligand binding site [chemical binding]; other site 1036743002727 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1036743002728 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1036743002729 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1036743002730 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1036743002731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743002732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002733 Walker A/P-loop; other site 1036743002734 ATP binding site [chemical binding]; other site 1036743002735 Q-loop/lid; other site 1036743002736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743002737 ABC transporter signature motif; other site 1036743002738 Walker B; other site 1036743002739 D-loop; other site 1036743002740 ABC transporter; Region: ABC_tran_2; pfam12848 1036743002741 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743002742 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743002743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002744 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743002745 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743002746 N-terminal plug; other site 1036743002747 ligand-binding site [chemical binding]; other site 1036743002748 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1036743002749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743002750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002751 Walker A/P-loop; other site 1036743002752 ATP binding site [chemical binding]; other site 1036743002753 Q-loop/lid; other site 1036743002754 ABC transporter signature motif; other site 1036743002755 Walker B; other site 1036743002756 D-loop; other site 1036743002757 H-loop/switch region; other site 1036743002758 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743002759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743002760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743002761 Walker A/P-loop; other site 1036743002762 ATP binding site [chemical binding]; other site 1036743002763 Q-loop/lid; other site 1036743002764 ABC transporter signature motif; other site 1036743002765 Walker B; other site 1036743002766 D-loop; other site 1036743002767 H-loop/switch region; other site 1036743002768 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1036743002769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743002770 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743002771 DNA binding residues [nucleotide binding] 1036743002772 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1036743002773 FecR protein; Region: FecR; pfam04773 1036743002774 Secretin and TonB N terminus short domain; Region: STN; smart00965 1036743002775 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1036743002776 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743002777 N-terminal plug; other site 1036743002778 ligand-binding site [chemical binding]; other site 1036743002779 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1036743002780 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743002781 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743002782 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743002783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743002784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743002785 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1036743002786 tellurite resistance protein terB; Region: terB; cd07176 1036743002787 putative metal binding site [ion binding]; other site 1036743002788 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1036743002789 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1036743002790 putative metal binding site [ion binding]; other site 1036743002791 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1036743002792 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1036743002793 putative metal binding site [ion binding]; other site 1036743002794 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1036743002795 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1036743002796 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1036743002797 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1036743002798 putative metal binding site [ion binding]; other site 1036743002799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1036743002800 non-specific DNA binding site [nucleotide binding]; other site 1036743002801 salt bridge; other site 1036743002802 sequence-specific DNA binding site [nucleotide binding]; other site 1036743002803 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1036743002804 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1036743002805 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1036743002806 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1036743002807 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1036743002808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743002809 active site 1036743002810 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1036743002811 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1036743002812 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1036743002813 conserved cys residue [active] 1036743002814 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1036743002815 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1036743002816 dimer interface [polypeptide binding]; other site 1036743002817 active site 1036743002818 glycine loop; other site 1036743002819 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1036743002820 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1036743002821 putative active site [active] 1036743002822 metal binding site [ion binding]; metal-binding site 1036743002823 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1036743002824 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1036743002825 Hexamer interface [polypeptide binding]; other site 1036743002826 Putative hexagonal pore residue; other site 1036743002827 propanediol utilization protein PduB; Provisional; Region: PRK15415 1036743002828 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1036743002829 putative hexamer interface [polypeptide binding]; other site 1036743002830 putative hexagonal pore; other site 1036743002831 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1036743002832 putative hexamer interface [polypeptide binding]; other site 1036743002833 putative hexagonal pore; other site 1036743002834 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1036743002835 Hexamer interface [polypeptide binding]; other site 1036743002836 Hexagonal pore residue; other site 1036743002837 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1036743002838 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1036743002839 Hexamer interface [polypeptide binding]; other site 1036743002840 Putative hexagonal pore residue; other site 1036743002841 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1036743002842 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1036743002843 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1036743002844 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 1036743002845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1036743002846 nucleotide binding site [chemical binding]; other site 1036743002847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1036743002848 nucleotide binding site [chemical binding]; other site 1036743002849 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1036743002850 Hexamer/Pentamer interface [polypeptide binding]; other site 1036743002851 central pore; other site 1036743002852 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1036743002853 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1036743002854 putative catalytic cysteine [active] 1036743002855 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 1036743002856 putative hexamer interface [polypeptide binding]; other site 1036743002857 putative hexagonal pore; other site 1036743002858 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1036743002859 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1036743002860 4Fe-4S binding domain; Region: Fer4; cl02805 1036743002861 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1036743002862 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1036743002863 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1036743002864 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1036743002865 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1036743002866 Sensory domain found in PocR; Region: PocR; pfam10114 1036743002867 Histidine kinase; Region: His_kinase; pfam06580 1036743002868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743002869 ATP binding site [chemical binding]; other site 1036743002870 Mg2+ binding site [ion binding]; other site 1036743002871 G-X-G motif; other site 1036743002872 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743002873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743002874 active site 1036743002875 phosphorylation site [posttranslational modification] 1036743002876 intermolecular recognition site; other site 1036743002877 dimerization interface [polypeptide binding]; other site 1036743002878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743002880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743002881 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1036743002882 propionate/acetate kinase; Provisional; Region: PRK12379 1036743002883 Predicted transcriptional regulator [Transcription]; Region: COG2944 1036743002884 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1036743002885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743002886 non-specific DNA binding site [nucleotide binding]; other site 1036743002887 salt bridge; other site 1036743002888 sequence-specific DNA binding site [nucleotide binding]; other site 1036743002889 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1036743002890 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1036743002891 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1036743002892 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743002893 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1036743002894 active site 1036743002895 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1036743002896 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1036743002897 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1036743002898 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1036743002899 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1036743002900 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1036743002901 dimer interface [polypeptide binding]; other site 1036743002902 active site 1036743002903 metal binding site [ion binding]; metal-binding site 1036743002904 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1036743002905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1036743002906 NAD(P) binding site [chemical binding]; other site 1036743002907 catalytic residues [active] 1036743002908 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1036743002909 GAF domain; Region: GAF; pfam01590 1036743002910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743002911 Walker A motif; other site 1036743002912 ATP binding site [chemical binding]; other site 1036743002913 Walker B motif; other site 1036743002914 arginine finger; other site 1036743002915 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743002916 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1036743002917 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1036743002918 inhibitor-cofactor binding pocket; inhibition site 1036743002919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743002920 catalytic residue [active] 1036743002921 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1036743002922 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 1036743002923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743002924 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1036743002925 NAD(P) binding site [chemical binding]; other site 1036743002926 active site 1036743002927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1036743002928 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1036743002929 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1036743002930 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1036743002931 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1036743002932 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1036743002933 active site 1036743002934 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1036743002935 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1036743002936 nucleotide binding pocket [chemical binding]; other site 1036743002937 K-X-D-G motif; other site 1036743002938 catalytic site [active] 1036743002939 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1036743002940 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1036743002941 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1036743002942 Dimer interface [polypeptide binding]; other site 1036743002943 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1036743002944 Walker A/P-loop; other site 1036743002945 ATP binding site [chemical binding]; other site 1036743002946 Q-loop/lid; other site 1036743002947 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1036743002948 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1036743002949 ABC transporter signature motif; other site 1036743002950 Walker B; other site 1036743002951 D-loop; other site 1036743002952 H-loop/switch region; other site 1036743002953 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1036743002954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743002955 binding surface 1036743002956 TPR motif; other site 1036743002957 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1036743002958 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1036743002959 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1036743002960 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1036743002961 cell division protein FtsZ; Validated; Region: PRK09330 1036743002962 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1036743002963 nucleotide binding site [chemical binding]; other site 1036743002964 SulA interaction site; other site 1036743002965 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1036743002966 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1036743002967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1036743002968 nucleotide binding site [chemical binding]; other site 1036743002969 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1036743002970 Cell division protein FtsA; Region: FtsA; pfam14450 1036743002971 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1036743002972 Cell division protein FtsQ; Region: FtsQ; pfam03799 1036743002973 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1036743002974 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1036743002975 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1036743002976 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1036743002977 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743002978 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1036743002979 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1036743002980 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1036743002981 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1036743002982 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1036743002983 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1036743002984 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1036743002985 active site 1036743002986 homodimer interface [polypeptide binding]; other site 1036743002987 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1036743002988 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1036743002989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1036743002990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1036743002991 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1036743002992 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1036743002993 Mg++ binding site [ion binding]; other site 1036743002994 putative catalytic motif [active] 1036743002995 putative substrate binding site [chemical binding]; other site 1036743002996 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 1036743002997 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1036743002998 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1036743002999 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1036743003000 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1036743003001 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1036743003002 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1036743003003 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1036743003004 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1036743003005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1036743003006 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1036743003007 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1036743003008 MraW methylase family; Region: Methyltransf_5; cl17771 1036743003009 cell division protein MraZ; Reviewed; Region: PRK00326 1036743003010 MraZ protein; Region: MraZ; pfam02381 1036743003011 MraZ protein; Region: MraZ; pfam02381 1036743003012 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1036743003013 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1036743003014 amidase catalytic site [active] 1036743003015 Zn binding residues [ion binding]; other site 1036743003016 substrate binding site [chemical binding]; other site 1036743003017 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1036743003018 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1036743003019 putative metal binding site [ion binding]; other site 1036743003020 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1036743003021 HSP70 interaction site [polypeptide binding]; other site 1036743003022 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1036743003023 Coenzyme A binding pocket [chemical binding]; other site 1036743003024 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1036743003025 active site 1036743003026 trimerization site [polypeptide binding]; other site 1036743003027 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1036743003028 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1036743003029 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1036743003030 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1036743003031 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1036743003032 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1036743003033 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1036743003034 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1036743003035 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1036743003036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743003037 Walker A motif; other site 1036743003038 ATP binding site [chemical binding]; other site 1036743003039 Walker B motif; other site 1036743003040 arginine finger; other site 1036743003041 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1036743003042 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1036743003043 metal ion-dependent adhesion site (MIDAS); other site 1036743003044 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1036743003045 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1036743003046 putative MPT binding site; other site 1036743003047 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1036743003048 Ligand binding site; other site 1036743003049 metal-binding site 1036743003050 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1036743003051 arogenate dehydrogenase; Region: PLN02256 1036743003052 Uncharacterized conserved protein [Function unknown]; Region: COG3461 1036743003053 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1036743003054 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1036743003055 PemK-like protein; Region: PemK; pfam02452 1036743003056 RelB antitoxin; Region: RelB; cl01171 1036743003057 MarR family; Region: MarR_2; pfam12802 1036743003058 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1036743003059 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743003060 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1036743003061 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1036743003062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003063 dimer interface [polypeptide binding]; other site 1036743003064 conserved gate region; other site 1036743003065 putative PBP binding loops; other site 1036743003066 ABC-ATPase subunit interface; other site 1036743003067 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1036743003068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003069 dimer interface [polypeptide binding]; other site 1036743003070 conserved gate region; other site 1036743003071 putative PBP binding loops; other site 1036743003072 ABC-ATPase subunit interface; other site 1036743003073 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1036743003074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743003075 Walker A/P-loop; other site 1036743003076 ATP binding site [chemical binding]; other site 1036743003077 Q-loop/lid; other site 1036743003078 ABC transporter signature motif; other site 1036743003079 Walker B; other site 1036743003080 D-loop; other site 1036743003081 H-loop/switch region; other site 1036743003082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743003083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743003084 Walker A/P-loop; other site 1036743003085 ATP binding site [chemical binding]; other site 1036743003086 Q-loop/lid; other site 1036743003087 ABC transporter signature motif; other site 1036743003088 Walker B; other site 1036743003089 D-loop; other site 1036743003090 H-loop/switch region; other site 1036743003091 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743003092 amidase; Provisional; Region: PRK07486 1036743003093 Amidase; Region: Amidase; cl11426 1036743003094 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1036743003095 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1036743003096 metal binding site [ion binding]; metal-binding site 1036743003097 putative dimer interface [polypeptide binding]; other site 1036743003098 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743003099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743003100 metal binding site [ion binding]; metal-binding site 1036743003101 active site 1036743003102 I-site; other site 1036743003103 AAA domain; Region: AAA_28; pfam13521 1036743003104 AAA domain; Region: AAA_17; pfam13207 1036743003105 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1036743003106 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1036743003107 C-terminal domain interface [polypeptide binding]; other site 1036743003108 GSH binding site (G-site) [chemical binding]; other site 1036743003109 dimer interface [polypeptide binding]; other site 1036743003110 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1036743003111 dimer interface [polypeptide binding]; other site 1036743003112 N-terminal domain interface [polypeptide binding]; other site 1036743003113 putative substrate binding pocket (H-site) [chemical binding]; other site 1036743003114 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1036743003115 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1036743003116 ligand binding site [chemical binding]; other site 1036743003117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743003118 dimerization interface [polypeptide binding]; other site 1036743003119 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743003120 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743003121 metal binding site [ion binding]; metal-binding site 1036743003122 active site 1036743003123 I-site; other site 1036743003124 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743003125 Predicted membrane protein [Function unknown]; Region: COG2860 1036743003126 UPF0126 domain; Region: UPF0126; pfam03458 1036743003127 UPF0126 domain; Region: UPF0126; pfam03458 1036743003128 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1036743003129 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1036743003130 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1036743003131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743003132 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1036743003133 Walker A motif; other site 1036743003134 ATP binding site [chemical binding]; other site 1036743003135 Walker B motif; other site 1036743003136 arginine finger; other site 1036743003137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743003138 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1036743003139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743003140 FeS/SAM binding site; other site 1036743003141 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1036743003142 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1036743003143 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 1036743003144 HEAT repeats; Region: HEAT_2; pfam13646 1036743003145 NifZ domain; Region: NifZ; pfam04319 1036743003146 NifT/FixU protein; Region: NifT; pfam06988 1036743003147 SIR2-like domain; Region: SIR2_2; pfam13289 1036743003148 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1036743003149 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1036743003150 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1036743003151 Walker A/P-loop; other site 1036743003152 ATP binding site [chemical binding]; other site 1036743003153 Q-loop/lid; other site 1036743003154 ABC transporter signature motif; other site 1036743003155 Walker B; other site 1036743003156 D-loop; other site 1036743003157 H-loop/switch region; other site 1036743003158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003159 dimer interface [polypeptide binding]; other site 1036743003160 conserved gate region; other site 1036743003161 ABC-ATPase subunit interface; other site 1036743003162 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1036743003163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003164 conserved gate region; other site 1036743003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003166 putative PBP binding loops; other site 1036743003167 dimer interface [polypeptide binding]; other site 1036743003168 ABC-ATPase subunit interface; other site 1036743003169 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1036743003170 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743003171 substrate binding pocket [chemical binding]; other site 1036743003172 membrane-bound complex binding site; other site 1036743003173 hinge residues; other site 1036743003174 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1036743003175 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1036743003176 Ligand binding site; other site 1036743003177 Putative Catalytic site; other site 1036743003178 DXD motif; other site 1036743003179 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1036743003180 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1036743003181 putative catalytic residues [active] 1036743003182 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 1036743003183 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 1036743003184 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1036743003185 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1036743003186 Nucleotide-binding sites [chemical binding]; other site 1036743003187 Walker A motif; other site 1036743003188 Switch I region of nucleotide binding site; other site 1036743003189 Fe4S4 binding sites [ion binding]; other site 1036743003190 Switch II region of nucleotide binding site; other site 1036743003191 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1036743003192 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1036743003193 MoFe protein alpha/beta subunit interactions; other site 1036743003194 Alpha subunit P cluster binding residues; other site 1036743003195 FeMoco binding residues [chemical binding]; other site 1036743003196 MoFe protein alpha subunit/Fe protein contacts; other site 1036743003197 MoFe protein dimer/ dimer interactions; other site 1036743003198 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1036743003199 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1036743003200 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1036743003201 MoFe protein beta/alpha subunit interactions; other site 1036743003202 Beta subunit P cluster binding residues; other site 1036743003203 MoFe protein beta subunit/Fe protein contacts; other site 1036743003204 MoFe protein dimer/ dimer interactions; other site 1036743003205 ABC transporter ATPase component; Reviewed; Region: PRK11147 1036743003206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743003207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743003208 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743003209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003210 dimer interface [polypeptide binding]; other site 1036743003211 conserved gate region; other site 1036743003212 putative PBP binding loops; other site 1036743003213 ABC-ATPase subunit interface; other site 1036743003214 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743003215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743003216 dimer interface [polypeptide binding]; other site 1036743003217 conserved gate region; other site 1036743003218 putative PBP binding loops; other site 1036743003219 ABC-ATPase subunit interface; other site 1036743003220 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1036743003221 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1036743003222 Walker A/P-loop; other site 1036743003223 ATP binding site [chemical binding]; other site 1036743003224 Q-loop/lid; other site 1036743003225 ABC transporter signature motif; other site 1036743003226 Walker B; other site 1036743003227 D-loop; other site 1036743003228 H-loop/switch region; other site 1036743003229 TOBE domain; Region: TOBE_2; pfam08402 1036743003230 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1036743003231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1036743003232 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1036743003233 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1036743003234 Cytochrome c; Region: Cytochrom_C; cl11414 1036743003235 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1036743003236 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1036743003237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743003238 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743003239 DNA binding residues [nucleotide binding] 1036743003240 Helix-turn-helix domain; Region: HTH_39; pfam14090 1036743003241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743003242 sequence-specific DNA binding site [nucleotide binding]; other site 1036743003243 salt bridge; other site 1036743003244 Predicted transcriptional regulator [Transcription]; Region: COG2932 1036743003245 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1036743003246 Catalytic site [active] 1036743003247 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1036743003248 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1036743003249 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1036743003250 DNA binding residues [nucleotide binding] 1036743003251 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1036743003252 dimer interface [polypeptide binding]; other site 1036743003253 putative metal binding site [ion binding]; other site 1036743003254 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1036743003255 metal-binding site [ion binding] 1036743003256 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1036743003257 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1036743003258 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1036743003259 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1036743003260 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743003261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743003262 ethanolamine permease; Region: 2A0305; TIGR00908 1036743003263 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1036743003264 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1036743003265 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1036743003266 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1036743003267 dimerization interface [polypeptide binding]; other site 1036743003268 metal binding site [ion binding]; metal-binding site 1036743003269 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1036743003270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743003271 PAS domain; Region: PAS_9; pfam13426 1036743003272 putative active site [active] 1036743003273 heme pocket [chemical binding]; other site 1036743003274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743003275 ATP binding site [chemical binding]; other site 1036743003276 Mg2+ binding site [ion binding]; other site 1036743003277 G-X-G motif; other site 1036743003278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743003279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743003280 metal binding site [ion binding]; metal-binding site 1036743003281 active site 1036743003282 I-site; other site 1036743003283 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743003284 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 1036743003285 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1036743003286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1036743003287 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1036743003288 active site 1036743003289 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1036743003290 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1036743003291 active site 1036743003292 nucleophile elbow; other site 1036743003293 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1036743003294 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1036743003295 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1036743003296 NAD binding site [chemical binding]; other site 1036743003297 Phe binding site; other site 1036743003298 transcriptional regulator; Provisional; Region: PRK10632 1036743003299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743003300 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1036743003301 putative effector binding pocket; other site 1036743003302 dimerization interface [polypeptide binding]; other site 1036743003303 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1036743003304 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1036743003305 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1036743003306 active site 1036743003307 catalytic residues [active] 1036743003308 metal binding site [ion binding]; metal-binding site 1036743003309 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 1036743003310 COQ9; Region: COQ9; pfam08511 1036743003311 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1036743003312 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1036743003313 acyl-activating enzyme (AAE) consensus motif; other site 1036743003314 putative AMP binding site [chemical binding]; other site 1036743003315 putative active site [active] 1036743003316 putative CoA binding site [chemical binding]; other site 1036743003317 6-phosphofructokinase; Provisional; Region: PRK14071 1036743003318 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1036743003319 active site 1036743003320 ADP/pyrophosphate binding site [chemical binding]; other site 1036743003321 dimerization interface [polypeptide binding]; other site 1036743003322 allosteric effector site; other site 1036743003323 fructose-1,6-bisphosphate binding site; other site 1036743003324 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 1036743003325 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1036743003326 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 1036743003327 ATP-grasp domain; Region: ATP-grasp; pfam02222 1036743003328 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743003329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743003330 active site 1036743003331 phosphorylation site [posttranslational modification] 1036743003332 intermolecular recognition site; other site 1036743003333 dimerization interface [polypeptide binding]; other site 1036743003334 PAS domain; Region: PAS; smart00091 1036743003335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743003336 dimer interface [polypeptide binding]; other site 1036743003337 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1036743003338 putative CheW interface [polypeptide binding]; other site 1036743003339 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1036743003340 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 1036743003341 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1036743003342 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1036743003343 NAD(P) binding site [chemical binding]; other site 1036743003344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743003345 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1036743003346 NAD(P) binding site [chemical binding]; other site 1036743003347 active site 1036743003348 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1036743003349 active site 1036743003350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1036743003351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1036743003352 active site 1036743003353 catalytic tetrad [active] 1036743003354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743003355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743003356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743003357 dimerization interface [polypeptide binding]; other site 1036743003358 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1036743003359 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1036743003360 oligomeric interface; other site 1036743003361 putative active site [active] 1036743003362 homodimer interface [polypeptide binding]; other site 1036743003363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743003364 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 1036743003365 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1036743003366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743003367 sequence-specific DNA binding site [nucleotide binding]; other site 1036743003368 salt bridge; other site 1036743003369 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1036743003370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743003371 Walker A/P-loop; other site 1036743003372 ATP binding site [chemical binding]; other site 1036743003373 Q-loop/lid; other site 1036743003374 ABC transporter signature motif; other site 1036743003375 Walker B; other site 1036743003376 H-loop/switch region; other site 1036743003377 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743003378 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1036743003379 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1036743003380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743003381 catalytic residue [active] 1036743003382 Predicted Fe-S protein [General function prediction only]; Region: COG2000 1036743003383 Putative Fe-S cluster; Region: FeS; cl17515 1036743003384 Src Homology 3 domain superfamily; Region: SH3; cl17036 1036743003385 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1036743003386 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1036743003387 putative dimer interface [polypeptide binding]; other site 1036743003388 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1036743003389 cyclase homology domain; Region: CHD; cd07302 1036743003390 nucleotidyl binding site; other site 1036743003391 metal binding site [ion binding]; metal-binding site 1036743003392 dimer interface [polypeptide binding]; other site 1036743003393 ribosomal protein L31; Region: L31; TIGR00105 1036743003394 hypothetical protein; Validated; Region: PRK09039 1036743003395 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743003396 ligand binding site [chemical binding]; other site 1036743003397 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743003398 ligand binding site [chemical binding]; other site 1036743003399 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1036743003400 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1036743003401 active site 1036743003402 dimerization interface [polypeptide binding]; other site 1036743003403 translation elongation factor P; Region: efp; TIGR00038 1036743003404 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1036743003405 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1036743003406 RNA binding site [nucleotide binding]; other site 1036743003407 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1036743003408 RNA binding site [nucleotide binding]; other site 1036743003409 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1036743003410 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1036743003411 motif 1; other site 1036743003412 dimer interface [polypeptide binding]; other site 1036743003413 active site 1036743003414 motif 2; other site 1036743003415 motif 3; other site 1036743003416 potassium/proton antiporter; Reviewed; Region: PRK05326 1036743003417 Transporter associated domain; Region: CorC_HlyC; smart01091 1036743003418 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1036743003419 thiamine phosphate binding site [chemical binding]; other site 1036743003420 active site 1036743003421 pyrophosphate binding site [ion binding]; other site 1036743003422 Cell division protein ZapA; Region: ZapA; pfam05164 1036743003423 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1036743003424 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1036743003425 putative active site [active] 1036743003426 metal binding site [ion binding]; metal-binding site 1036743003427 homodimer binding site [polypeptide binding]; other site 1036743003428 hypothetical protein; Validated; Region: PRK00110 1036743003429 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1036743003430 active site 1036743003431 putative DNA-binding cleft [nucleotide binding]; other site 1036743003432 dimer interface [polypeptide binding]; other site 1036743003433 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1036743003434 RuvA N terminal domain; Region: RuvA_N; pfam01330 1036743003435 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1036743003436 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1036743003437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743003438 Walker A motif; other site 1036743003439 ATP binding site [chemical binding]; other site 1036743003440 Walker B motif; other site 1036743003441 arginine finger; other site 1036743003442 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1036743003443 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1036743003444 active site 1036743003445 TolQ protein; Region: tolQ; TIGR02796 1036743003446 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1036743003447 TolR protein; Region: tolR; TIGR02801 1036743003448 TolA protein; Region: tolA_full; TIGR02794 1036743003449 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1036743003450 translocation protein TolB; Provisional; Region: tolB; PRK05137 1036743003451 TolB amino-terminal domain; Region: TolB_N; pfam04052 1036743003452 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1036743003453 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1036743003454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743003455 ligand binding site [chemical binding]; other site 1036743003456 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1036743003457 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1036743003458 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1036743003459 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1036743003460 Ligand Binding Site [chemical binding]; other site 1036743003461 FtsH Extracellular; Region: FtsH_ext; pfam06480 1036743003462 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1036743003463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743003464 Walker A motif; other site 1036743003465 ATP binding site [chemical binding]; other site 1036743003466 Walker B motif; other site 1036743003467 arginine finger; other site 1036743003468 Peptidase family M41; Region: Peptidase_M41; pfam01434 1036743003469 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1036743003470 dihydropteroate synthase; Region: DHPS; TIGR01496 1036743003471 substrate binding pocket [chemical binding]; other site 1036743003472 dimer interface [polypeptide binding]; other site 1036743003473 inhibitor binding site; inhibition site 1036743003474 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1036743003475 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1036743003476 active site 1036743003477 substrate binding site [chemical binding]; other site 1036743003478 metal binding site [ion binding]; metal-binding site 1036743003479 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1036743003480 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1036743003481 dimer interface [polypeptide binding]; other site 1036743003482 substrate binding site [chemical binding]; other site 1036743003483 ATP binding site [chemical binding]; other site 1036743003484 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1036743003485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1036743003486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743003487 catalytic residue [active] 1036743003488 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1036743003489 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1036743003490 dimer interface [polypeptide binding]; other site 1036743003491 motif 1; other site 1036743003492 active site 1036743003493 motif 2; other site 1036743003494 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1036743003495 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1036743003496 GDP-binding site [chemical binding]; other site 1036743003497 ACT binding site; other site 1036743003498 IMP binding site; other site 1036743003499 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1036743003500 active site 1036743003501 ATP binding site [chemical binding]; other site 1036743003502 substrate binding site [chemical binding]; other site 1036743003503 activation loop (A-loop); other site 1036743003504 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743003505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743003506 dimerization interface [polypeptide binding]; other site 1036743003507 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743003508 dimer interface [polypeptide binding]; other site 1036743003509 putative CheW interface [polypeptide binding]; other site 1036743003510 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1036743003511 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1036743003512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743003513 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1036743003514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743003515 DNA binding residues [nucleotide binding] 1036743003516 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1036743003517 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1036743003518 RNA binding surface [nucleotide binding]; other site 1036743003519 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1036743003520 active site 1036743003521 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1036743003522 MPN+ (JAMM) motif; other site 1036743003523 Zinc-binding site [ion binding]; other site 1036743003524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743003525 putative substrate translocation pore; other site 1036743003526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743003527 Helix-turn-helix domain; Region: HTH_31; pfam13560 1036743003528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743003529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743003530 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1036743003531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743003532 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743003533 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1036743003534 Protein export membrane protein; Region: SecD_SecF; cl14618 1036743003535 NnrS protein; Region: NnrS; pfam05940 1036743003536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743003537 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1036743003538 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1036743003539 Walker A/P-loop; other site 1036743003540 ATP binding site [chemical binding]; other site 1036743003541 Q-loop/lid; other site 1036743003542 ABC transporter signature motif; other site 1036743003543 Walker B; other site 1036743003544 D-loop; other site 1036743003545 H-loop/switch region; other site 1036743003546 pyruvate carboxylase; Reviewed; Region: PRK12999 1036743003547 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743003548 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1036743003549 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1036743003550 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1036743003551 active site 1036743003552 catalytic residues [active] 1036743003553 metal binding site [ion binding]; metal-binding site 1036743003554 homodimer binding site [polypeptide binding]; other site 1036743003555 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743003556 carboxyltransferase (CT) interaction site; other site 1036743003557 biotinylation site [posttranslational modification]; other site 1036743003558 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1036743003559 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1036743003560 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1036743003561 putative deacylase active site [active] 1036743003562 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743003563 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743003564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743003565 sequence-specific DNA binding site [nucleotide binding]; other site 1036743003566 salt bridge; other site 1036743003567 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1036743003568 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1036743003569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1036743003570 Integrase core domain; Region: rve; pfam00665 1036743003571 Integrase core domain; Region: rve_3; pfam13683 1036743003572 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1036743003573 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1036743003574 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1036743003575 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1036743003576 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1036743003577 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1036743003578 substrate-cofactor binding pocket; other site 1036743003579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743003580 catalytic residue [active] 1036743003581 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1036743003582 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1036743003583 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1036743003584 excinuclease ABC subunit B; Provisional; Region: PRK05298 1036743003585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743003586 ATP binding site [chemical binding]; other site 1036743003587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743003588 nucleotide binding region [chemical binding]; other site 1036743003589 ATP-binding site [chemical binding]; other site 1036743003590 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1036743003591 UvrB/uvrC motif; Region: UVR; pfam02151 1036743003592 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1036743003593 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1036743003594 aspartate aminotransferase; Provisional; Region: PRK05764 1036743003595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743003596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743003597 homodimer interface [polypeptide binding]; other site 1036743003598 catalytic residue [active] 1036743003599 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1036743003600 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1036743003601 putative ligand binding residues [chemical binding]; other site 1036743003602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1036743003603 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1036743003604 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1036743003605 ABC-ATPase subunit interface; other site 1036743003606 dimer interface [polypeptide binding]; other site 1036743003607 putative PBP binding regions; other site 1036743003608 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1036743003609 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1036743003610 Walker A/P-loop; other site 1036743003611 ATP binding site [chemical binding]; other site 1036743003612 Q-loop/lid; other site 1036743003613 ABC transporter signature motif; other site 1036743003614 Walker B; other site 1036743003615 D-loop; other site 1036743003616 H-loop/switch region; other site 1036743003617 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1036743003618 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1036743003619 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1036743003620 elongation factor G; Reviewed; Region: PRK12740 1036743003621 G1 box; other site 1036743003622 putative GEF interaction site [polypeptide binding]; other site 1036743003623 GTP/Mg2+ binding site [chemical binding]; other site 1036743003624 Switch I region; other site 1036743003625 G2 box; other site 1036743003626 G3 box; other site 1036743003627 Switch II region; other site 1036743003628 G4 box; other site 1036743003629 G5 box; other site 1036743003630 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1036743003631 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1036743003632 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1036743003633 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1036743003634 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743003635 catalytic residue [active] 1036743003636 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1036743003637 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1036743003638 dimer interface [polypeptide binding]; other site 1036743003639 active site 1036743003640 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1036743003641 folate binding site [chemical binding]; other site 1036743003642 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1036743003643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743003644 DNA-binding site [nucleotide binding]; DNA binding site 1036743003645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743003646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743003647 homodimer interface [polypeptide binding]; other site 1036743003648 catalytic residue [active] 1036743003649 benzoate transporter; Region: benE; TIGR00843 1036743003650 Benzoate membrane transport protein; Region: BenE; pfam03594 1036743003651 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1036743003652 dimer interface [polypeptide binding]; other site 1036743003653 pyridoxal binding site [chemical binding]; other site 1036743003654 ATP binding site [chemical binding]; other site 1036743003655 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1036743003656 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1036743003657 substrate-cofactor binding pocket; other site 1036743003658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743003659 catalytic residue [active] 1036743003660 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1036743003661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743003662 inhibitor-cofactor binding pocket; inhibition site 1036743003663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743003664 catalytic residue [active] 1036743003665 CRISPR-associated protein; Region: TIGR03986 1036743003666 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1036743003667 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1036743003668 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1036743003669 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1036743003670 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 1036743003671 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1036743003672 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1036743003673 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1036743003674 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1036743003675 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1036743003676 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1036743003677 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1036743003678 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1036743003679 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1036743003680 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1036743003681 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1036743003682 Ligand Binding Site [chemical binding]; other site 1036743003683 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1036743003684 GAF domain; Region: GAF_3; pfam13492 1036743003685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743003686 dimer interface [polypeptide binding]; other site 1036743003687 phosphorylation site [posttranslational modification] 1036743003688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743003689 ATP binding site [chemical binding]; other site 1036743003690 Mg2+ binding site [ion binding]; other site 1036743003691 G-X-G motif; other site 1036743003692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743003694 active site 1036743003695 phosphorylation site [posttranslational modification] 1036743003696 intermolecular recognition site; other site 1036743003697 dimerization interface [polypeptide binding]; other site 1036743003698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743003699 DNA binding site [nucleotide binding] 1036743003700 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743003701 HAMP domain; Region: HAMP; pfam00672 1036743003702 dimerization interface [polypeptide binding]; other site 1036743003703 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743003704 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1036743003705 dimer interface [polypeptide binding]; other site 1036743003706 putative CheW interface [polypeptide binding]; other site 1036743003707 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1036743003708 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1036743003709 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1036743003710 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1036743003711 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1036743003712 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1036743003713 putative substrate-binding site; other site 1036743003714 nickel binding site [ion binding]; other site 1036743003715 HupF/HypC family; Region: HupF_HypC; pfam01455 1036743003716 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1036743003717 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1036743003718 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1036743003719 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1036743003720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743003721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1036743003722 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1036743003723 phosphorylation site [posttranslational modification] 1036743003724 intermolecular recognition site; other site 1036743003725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743003726 Walker A motif; other site 1036743003727 ATP binding site [chemical binding]; other site 1036743003728 Walker B motif; other site 1036743003729 arginine finger; other site 1036743003730 Predicted transcriptional regulator [Transcription]; Region: COG1959 1036743003731 Transcriptional regulator; Region: Rrf2; pfam02082 1036743003732 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743003733 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1036743003734 putative DNA binding site [nucleotide binding]; other site 1036743003735 putative Zn2+ binding site [ion binding]; other site 1036743003736 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743003737 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1036743003738 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1036743003739 homotrimer interaction site [polypeptide binding]; other site 1036743003740 putative active site [active] 1036743003741 CsbD-like; Region: CsbD; cl17424 1036743003742 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1036743003743 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1036743003744 active site 1036743003745 Zn binding site [ion binding]; other site 1036743003746 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1036743003747 heme-binding site [chemical binding]; other site 1036743003748 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743003749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743003750 dimer interface [polypeptide binding]; other site 1036743003751 putative CheW interface [polypeptide binding]; other site 1036743003752 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1036743003753 motif 1; other site 1036743003754 dimer interface [polypeptide binding]; other site 1036743003755 active site 1036743003756 motif 2; other site 1036743003757 anticodon binding site; other site 1036743003758 Anticodon binding domain; Region: HGTP_anticodon; pfam03129 1036743003759 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1036743003760 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1036743003761 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1036743003762 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1036743003763 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1036743003764 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1036743003765 P loop; other site 1036743003766 GTP binding site [chemical binding]; other site 1036743003767 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1036743003768 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1036743003769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743003770 FeS/SAM binding site; other site 1036743003771 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1036743003772 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1036743003773 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1036743003774 signal recognition particle protein; Provisional; Region: PRK10867 1036743003775 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1036743003776 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1036743003777 P loop; other site 1036743003778 GTP binding site [chemical binding]; other site 1036743003779 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1036743003780 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1036743003781 RimM N-terminal domain; Region: RimM; pfam01782 1036743003782 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 1036743003783 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1036743003784 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1036743003785 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1036743003786 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1036743003787 substrate binding site [chemical binding]; other site 1036743003788 ligand binding site [chemical binding]; other site 1036743003789 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1036743003790 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1036743003791 substrate binding site [chemical binding]; other site 1036743003792 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1036743003793 tartrate dehydrogenase; Region: TTC; TIGR02089 1036743003794 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1036743003795 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1036743003796 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1036743003797 [2Fe-2S] cluster binding site [ion binding]; other site 1036743003798 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 1036743003799 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 1036743003800 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1036743003801 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1036743003802 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1036743003803 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743003804 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743003805 dimer interface [polypeptide binding]; other site 1036743003806 putative CheW interface [polypeptide binding]; other site 1036743003807 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1036743003808 pyridoxal binding site [chemical binding]; other site 1036743003809 dimer interface [polypeptide binding]; other site 1036743003810 ATP binding site [chemical binding]; other site 1036743003811 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1036743003812 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1036743003813 putative active site [active] 1036743003814 putative catalytic site [active] 1036743003815 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1036743003816 putative active site [active] 1036743003817 putative catalytic site [active] 1036743003818 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1036743003819 Iron-sulfur protein interface; other site 1036743003820 proximal quinone binding site [chemical binding]; other site 1036743003821 SdhD (CybS) interface [polypeptide binding]; other site 1036743003822 proximal heme binding site [chemical binding]; other site 1036743003823 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1036743003824 putative SdhC subunit interface [polypeptide binding]; other site 1036743003825 putative proximal heme binding site [chemical binding]; other site 1036743003826 putative Iron-sulfur protein interface [polypeptide binding]; other site 1036743003827 putative proximal quinone binding site; other site 1036743003828 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1036743003829 L-aspartate oxidase; Provisional; Region: PRK06175 1036743003830 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1036743003831 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1036743003832 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1036743003833 ATR interacting protein; Provisional; Region: PLN03205 1036743003834 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1036743003835 Predicted ATPase [General function prediction only]; Region: COG1485 1036743003836 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1036743003837 Chromate transporter; Region: Chromate_transp; cl17781 1036743003838 malate dehydrogenase; Reviewed; Region: PRK06223 1036743003839 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1036743003840 NAD(P) binding site [chemical binding]; other site 1036743003841 dimer interface [polypeptide binding]; other site 1036743003842 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1036743003843 substrate binding site [chemical binding]; other site 1036743003844 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1036743003845 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1036743003846 CoA-ligase; Region: Ligase_CoA; pfam00549 1036743003847 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1036743003848 CoA binding domain; Region: CoA_binding; pfam02629 1036743003849 CoA-ligase; Region: Ligase_CoA; pfam00549 1036743003850 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1036743003851 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1036743003852 TPP-binding site [chemical binding]; other site 1036743003853 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1036743003854 dimer interface [polypeptide binding]; other site 1036743003855 PYR/PP interface [polypeptide binding]; other site 1036743003856 TPP binding site [chemical binding]; other site 1036743003857 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1036743003858 E3 interaction surface; other site 1036743003859 lipoyl attachment site [posttranslational modification]; other site 1036743003860 e3 binding domain; Region: E3_binding; pfam02817 1036743003861 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1036743003862 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1036743003863 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1036743003864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743003865 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1036743003866 phage shock protein C; Region: phageshock_pspC; TIGR02978 1036743003867 PspC domain; Region: PspC; cl00864 1036743003868 PspC domain; Region: PspC; cl00864 1036743003869 Phage shock protein B; Region: PspB; pfam06667 1036743003870 phage shock protein A; Region: phageshock_pspA; TIGR02977 1036743003871 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1036743003872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743003873 Walker A motif; other site 1036743003874 ATP binding site [chemical binding]; other site 1036743003875 Walker B motif; other site 1036743003876 arginine finger; other site 1036743003877 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1036743003878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1036743003879 active site 1036743003880 DNA binding site [nucleotide binding] 1036743003881 Int/Topo IB signature motif; other site 1036743003882 Protein of unknown function, DUF484; Region: DUF484; cl17449 1036743003883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743003884 primosomal protein N' Region: priA; TIGR00595 1036743003885 ATP binding site [chemical binding]; other site 1036743003886 putative Mg++ binding site [ion binding]; other site 1036743003887 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1036743003888 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1036743003889 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1036743003890 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1036743003891 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1036743003892 beta subunit interaction interface [polypeptide binding]; other site 1036743003893 Walker A motif; other site 1036743003894 ATP binding site [chemical binding]; other site 1036743003895 Walker B motif; other site 1036743003896 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1036743003897 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1036743003898 core domain interface [polypeptide binding]; other site 1036743003899 delta subunit interface [polypeptide binding]; other site 1036743003900 epsilon subunit interface [polypeptide binding]; other site 1036743003901 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1036743003902 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1036743003903 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1036743003904 alpha subunit interaction interface [polypeptide binding]; other site 1036743003905 Walker A motif; other site 1036743003906 ATP binding site [chemical binding]; other site 1036743003907 Walker B motif; other site 1036743003908 inhibitor binding site; inhibition site 1036743003909 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1036743003910 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 1036743003911 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1036743003912 gamma subunit interface [polypeptide binding]; other site 1036743003913 epsilon subunit interface [polypeptide binding]; other site 1036743003914 LBP interface [polypeptide binding]; other site 1036743003915 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1036743003916 dinuclear metal binding motif [ion binding]; other site 1036743003917 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1036743003918 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1036743003919 putative active site [active] 1036743003920 Ap4A binding site [chemical binding]; other site 1036743003921 nudix motif; other site 1036743003922 putative metal binding site [ion binding]; other site 1036743003923 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1036743003924 NodB motif; other site 1036743003925 putative active site [active] 1036743003926 putative catalytic site [active] 1036743003927 Zn binding site [ion binding]; other site 1036743003928 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1036743003929 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1036743003930 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1036743003931 protein binding site [polypeptide binding]; other site 1036743003932 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1036743003933 Catalytic dyad [active] 1036743003934 Peptidase family M23; Region: Peptidase_M23; pfam01551 1036743003935 phosphoglyceromutase; Provisional; Region: PRK05434 1036743003936 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1036743003937 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1036743003938 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1036743003939 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1036743003940 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1036743003941 active site 1036743003942 (T/H)XGH motif; other site 1036743003943 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1036743003944 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1036743003945 putative catalytic cysteine [active] 1036743003946 gamma-glutamyl kinase; Provisional; Region: PRK05429 1036743003947 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1036743003948 nucleotide binding site [chemical binding]; other site 1036743003949 homotetrameric interface [polypeptide binding]; other site 1036743003950 putative phosphate binding site [ion binding]; other site 1036743003951 putative allosteric binding site; other site 1036743003952 PUA domain; Region: PUA; pfam01472 1036743003953 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1036743003954 GTP1/OBG; Region: GTP1_OBG; pfam01018 1036743003955 Obg GTPase; Region: Obg; cd01898 1036743003956 G1 box; other site 1036743003957 GTP/Mg2+ binding site [chemical binding]; other site 1036743003958 Switch I region; other site 1036743003959 G2 box; other site 1036743003960 G3 box; other site 1036743003961 Switch II region; other site 1036743003962 G4 box; other site 1036743003963 G5 box; other site 1036743003964 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1036743003965 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1036743003966 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1036743003967 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1036743003968 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743003969 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743003970 ligand binding site [chemical binding]; other site 1036743003971 flexible hinge region; other site 1036743003972 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1036743003973 putative switch regulator; other site 1036743003974 non-specific DNA interactions [nucleotide binding]; other site 1036743003975 DNA binding site [nucleotide binding] 1036743003976 sequence specific DNA binding site [nucleotide binding]; other site 1036743003977 putative cAMP binding site [chemical binding]; other site 1036743003978 HipA N-terminal domain; Region: Couple_hipA; cl11853 1036743003979 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1036743003980 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1036743003981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743003982 non-specific DNA binding site [nucleotide binding]; other site 1036743003983 salt bridge; other site 1036743003984 sequence-specific DNA binding site [nucleotide binding]; other site 1036743003985 AAA domain; Region: AAA_17; pfam13207 1036743003986 Shikimate kinase; Region: SKI; pfam01202 1036743003987 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1036743003988 Beta-lactamase; Region: Beta-lactamase; pfam00144 1036743003989 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1036743003990 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1036743003991 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1036743003992 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1036743003993 putative aminotransferase; Validated; Region: PRK07480 1036743003994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743003995 inhibitor-cofactor binding pocket; inhibition site 1036743003996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743003997 catalytic residue [active] 1036743003998 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1036743003999 FCD domain; Region: FCD; pfam07729 1036743004000 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 1036743004001 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1036743004002 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1036743004003 Walker A/P-loop; other site 1036743004004 ATP binding site [chemical binding]; other site 1036743004005 Q-loop/lid; other site 1036743004006 ABC transporter signature motif; other site 1036743004007 Walker B; other site 1036743004008 D-loop; other site 1036743004009 H-loop/switch region; other site 1036743004010 TOBE domain; Region: TOBE_2; pfam08402 1036743004011 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743004012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743004013 dimer interface [polypeptide binding]; other site 1036743004014 conserved gate region; other site 1036743004015 putative PBP binding loops; other site 1036743004016 ABC-ATPase subunit interface; other site 1036743004017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1036743004018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1036743004019 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1036743004020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743004021 dimer interface [polypeptide binding]; other site 1036743004022 conserved gate region; other site 1036743004023 putative PBP binding loops; other site 1036743004024 ABC-ATPase subunit interface; other site 1036743004025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1036743004026 classical (c) SDRs; Region: SDR_c; cd05233 1036743004027 NAD(P) binding site [chemical binding]; other site 1036743004028 active site 1036743004029 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1036743004030 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1036743004031 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1036743004032 BtpA family; Region: BtpA; cl00440 1036743004033 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1036743004034 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 1036743004035 N- and C-terminal domain interface [polypeptide binding]; other site 1036743004036 putative active site [active] 1036743004037 MgATP binding site [chemical binding]; other site 1036743004038 catalytic site [active] 1036743004039 metal binding site [ion binding]; metal-binding site 1036743004040 putative xylulose binding site [chemical binding]; other site 1036743004041 putative homodimer interface [polypeptide binding]; other site 1036743004042 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1036743004043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743004044 motif II; other site 1036743004045 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1036743004046 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1036743004047 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1036743004048 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1036743004049 active site 1036743004050 metal binding site [ion binding]; metal-binding site 1036743004051 DNA binding site [nucleotide binding] 1036743004052 PAS domain S-box; Region: sensory_box; TIGR00229 1036743004053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743004054 putative active site [active] 1036743004055 heme pocket [chemical binding]; other site 1036743004056 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743004057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743004058 metal binding site [ion binding]; metal-binding site 1036743004059 active site 1036743004060 I-site; other site 1036743004061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1036743004062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743004063 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1036743004064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743004065 FeS/SAM binding site; other site 1036743004066 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1036743004067 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1036743004068 ATP cone domain; Region: ATP-cone; pfam03477 1036743004069 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1036743004070 effector binding site; other site 1036743004071 active site 1036743004072 Zn binding site [ion binding]; other site 1036743004073 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743004074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743004075 dimer interface [polypeptide binding]; other site 1036743004076 phosphorylation site [posttranslational modification] 1036743004077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743004078 ATP binding site [chemical binding]; other site 1036743004079 Mg2+ binding site [ion binding]; other site 1036743004080 G-X-G motif; other site 1036743004081 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1036743004082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004083 active site 1036743004084 phosphorylation site [posttranslational modification] 1036743004085 intermolecular recognition site; other site 1036743004086 dimerization interface [polypeptide binding]; other site 1036743004087 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1036743004088 active site 1036743004089 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743004090 Ligand Binding Site [chemical binding]; other site 1036743004091 Molecular Tunnel; other site 1036743004092 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1036743004093 active site 1036743004094 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1036743004095 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1036743004096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004097 active site 1036743004098 phosphorylation site [posttranslational modification] 1036743004099 intermolecular recognition site; other site 1036743004100 dimerization interface [polypeptide binding]; other site 1036743004101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743004102 DNA binding site [nucleotide binding] 1036743004103 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1036743004104 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1036743004105 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1036743004106 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743004107 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1036743004108 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1036743004109 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1036743004110 structural tetrad; other site 1036743004111 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1036743004112 structural tetrad; other site 1036743004113 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1036743004114 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1036743004115 structural tetrad; other site 1036743004116 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1036743004117 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1036743004118 molybdopterin cofactor binding site [chemical binding]; other site 1036743004119 substrate binding site [chemical binding]; other site 1036743004120 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1036743004121 molybdopterin cofactor binding site; other site 1036743004122 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1036743004123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743004124 FeS/SAM binding site; other site 1036743004125 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1036743004126 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1036743004127 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1036743004128 dimer interface [polypeptide binding]; other site 1036743004129 active site 1036743004130 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1036743004131 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1036743004132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743004133 Walker A/P-loop; other site 1036743004134 ATP binding site [chemical binding]; other site 1036743004135 Q-loop/lid; other site 1036743004136 ABC transporter signature motif; other site 1036743004137 Walker B; other site 1036743004138 D-loop; other site 1036743004139 H-loop/switch region; other site 1036743004140 FtsX-like permease family; Region: FtsX; pfam02687 1036743004141 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743004142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743004143 dimerization interface [polypeptide binding]; other site 1036743004144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743004145 dimer interface [polypeptide binding]; other site 1036743004146 putative CheW interface [polypeptide binding]; other site 1036743004147 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1036743004148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743004149 DNA-binding site [nucleotide binding]; DNA binding site 1036743004150 UTRA domain; Region: UTRA; pfam07702 1036743004151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1036743004152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743004153 substrate binding pocket [chemical binding]; other site 1036743004154 membrane-bound complex binding site; other site 1036743004155 hinge residues; other site 1036743004156 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1036743004157 ABC-ATPase subunit interface; other site 1036743004158 putative PBP binding loops; other site 1036743004159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1036743004160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743004161 dimer interface [polypeptide binding]; other site 1036743004162 conserved gate region; other site 1036743004163 putative PBP binding loops; other site 1036743004164 ABC-ATPase subunit interface; other site 1036743004165 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1036743004166 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1036743004167 Walker A/P-loop; other site 1036743004168 ATP binding site [chemical binding]; other site 1036743004169 Q-loop/lid; other site 1036743004170 ABC transporter signature motif; other site 1036743004171 Walker B; other site 1036743004172 D-loop; other site 1036743004173 H-loop/switch region; other site 1036743004174 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743004175 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743004176 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1036743004177 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1036743004178 active sites [active] 1036743004179 tetramer interface [polypeptide binding]; other site 1036743004180 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1036743004181 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1036743004182 active site 1036743004183 imidazolonepropionase; Validated; Region: PRK09356 1036743004184 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1036743004185 active site 1036743004186 urocanate hydratase; Provisional; Region: PRK05414 1036743004187 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1036743004188 short chain dehydrogenase; Provisional; Region: PRK08278 1036743004189 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1036743004190 NAD(P) binding site [chemical binding]; other site 1036743004191 homodimer interface [polypeptide binding]; other site 1036743004192 active site 1036743004193 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1036743004194 active site 1036743004195 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1036743004196 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1036743004197 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1036743004198 active site 1036743004199 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1036743004200 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1036743004201 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1036743004202 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1036743004203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743004204 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1036743004205 substrate binding site [chemical binding]; other site 1036743004206 oxyanion hole (OAH) forming residues; other site 1036743004207 trimer interface [polypeptide binding]; other site 1036743004208 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1036743004209 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1036743004210 dimer interface [polypeptide binding]; other site 1036743004211 active site 1036743004212 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1036743004213 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1036743004214 DNA binding residues [nucleotide binding] 1036743004215 putative dimer interface [polypeptide binding]; other site 1036743004216 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1036743004217 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1036743004218 acyl-activating enzyme (AAE) consensus motif; other site 1036743004219 putative AMP binding site [chemical binding]; other site 1036743004220 putative active site [active] 1036743004221 putative CoA binding site [chemical binding]; other site 1036743004222 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1036743004223 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1036743004224 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1036743004225 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1036743004226 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1036743004227 dimer interface [polypeptide binding]; other site 1036743004228 acyl-activating enzyme (AAE) consensus motif; other site 1036743004229 putative active site [active] 1036743004230 AMP binding site [chemical binding]; other site 1036743004231 putative CoA binding site [chemical binding]; other site 1036743004232 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1036743004233 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1036743004234 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1036743004235 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1036743004236 RNA binding site [nucleotide binding]; other site 1036743004237 hexamer interface [polypeptide binding]; other site 1036743004238 Histidine-zinc binding site [chemical binding]; other site 1036743004239 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 1036743004240 Na+-transporting malonate decarboxylase, carboxybiotin decarboxylase subunit; Region: malonate_biotin; TIGR03136 1036743004241 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1036743004242 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1036743004243 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1036743004244 Coenzyme A transferase; Region: CoA_trans; cl17247 1036743004245 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 1036743004246 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1036743004247 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1036743004248 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1036743004249 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1036743004250 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 1036743004251 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743004252 carboxyltransferase (CT) interaction site; other site 1036743004253 biotinylation site [posttranslational modification]; other site 1036743004254 Malonate transporter MadL subunit; Region: MadL; cl04273 1036743004255 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1036743004256 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1036743004257 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1036743004258 Walker A/P-loop; other site 1036743004259 ATP binding site [chemical binding]; other site 1036743004260 Q-loop/lid; other site 1036743004261 ABC transporter signature motif; other site 1036743004262 Walker B; other site 1036743004263 D-loop; other site 1036743004264 H-loop/switch region; other site 1036743004265 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1036743004266 BioY family; Region: BioY; pfam02632 1036743004267 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1036743004268 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743004269 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1036743004270 TM-ABC transporter signature motif; other site 1036743004271 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1036743004272 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1036743004273 ligand binding site [chemical binding]; other site 1036743004274 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1036743004275 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1036743004276 Walker A/P-loop; other site 1036743004277 ATP binding site [chemical binding]; other site 1036743004278 Q-loop/lid; other site 1036743004279 ABC transporter signature motif; other site 1036743004280 Walker B; other site 1036743004281 D-loop; other site 1036743004282 H-loop/switch region; other site 1036743004283 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1036743004284 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743004285 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1036743004286 TM-ABC transporter signature motif; other site 1036743004287 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1036743004288 Helix-turn-helix domain; Region: HTH_28; pfam13518 1036743004289 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1036743004290 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1036743004291 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1036743004292 DAK2 domain; Region: Dak2; pfam02734 1036743004293 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1036743004294 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1036743004295 MlrC C-terminus; Region: MlrC_C; pfam07171 1036743004296 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1036743004297 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1036743004298 Bacterial transcriptional regulator; Region: IclR; pfam01614 1036743004299 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1036743004300 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1036743004301 putative active site; other site 1036743004302 catalytic residue [active] 1036743004303 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1036743004304 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1036743004305 N- and C-terminal domain interface [polypeptide binding]; other site 1036743004306 active site 1036743004307 MgATP binding site [chemical binding]; other site 1036743004308 catalytic site [active] 1036743004309 metal binding site [ion binding]; metal-binding site 1036743004310 carbohydrate binding site [chemical binding]; other site 1036743004311 putative homodimer interface [polypeptide binding]; other site 1036743004312 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1036743004313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743004314 DNA-binding site [nucleotide binding]; DNA binding site 1036743004315 FCD domain; Region: FCD; pfam07729 1036743004316 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1036743004317 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1036743004318 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1036743004319 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1036743004320 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1036743004321 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1036743004322 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1036743004323 Domain of unknown function (DUF892); Region: DUF892; pfam05974 1036743004324 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1036743004325 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1036743004326 heme binding pocket [chemical binding]; other site 1036743004327 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1036743004328 domain interactions; other site 1036743004329 transaldolase-like protein; Provisional; Region: PTZ00411 1036743004330 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1036743004331 active site 1036743004332 dimer interface [polypeptide binding]; other site 1036743004333 catalytic residue [active] 1036743004334 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1036743004335 substrate binding site [chemical binding]; other site 1036743004336 dimer interface [polypeptide binding]; other site 1036743004337 triosephosphate isomerase; Provisional; Region: PRK14565 1036743004338 catalytic triad [active] 1036743004339 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1036743004340 DAK2 domain; Region: Dak2; cl03685 1036743004341 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1036743004342 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1036743004343 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1036743004344 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743004345 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1036743004346 TM-ABC transporter signature motif; other site 1036743004347 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1036743004348 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1036743004349 Walker A/P-loop; other site 1036743004350 ATP binding site [chemical binding]; other site 1036743004351 Q-loop/lid; other site 1036743004352 ABC transporter signature motif; other site 1036743004353 Walker B; other site 1036743004354 D-loop; other site 1036743004355 H-loop/switch region; other site 1036743004356 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1036743004357 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1036743004358 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1036743004359 ligand binding site [chemical binding]; other site 1036743004360 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1036743004361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1036743004362 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1036743004363 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1036743004364 tetramer interface [polypeptide binding]; other site 1036743004365 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1036743004366 active site 1036743004367 Caspase domain; Region: Peptidase_C14; pfam00656 1036743004368 Caspase domain; Region: Peptidase_C14; pfam00656 1036743004369 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1036743004370 propionate/acetate kinase; Provisional; Region: PRK12379 1036743004371 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1036743004372 putative acyltransferase; Provisional; Region: PRK05790 1036743004373 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1036743004374 dimer interface [polypeptide binding]; other site 1036743004375 active site 1036743004376 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1036743004377 Coenzyme A transferase; Region: CoA_trans; cl17247 1036743004378 Coenzyme A transferase; Region: CoA_trans; cl17247 1036743004379 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1036743004380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743004381 putative active site [active] 1036743004382 heme pocket [chemical binding]; other site 1036743004383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743004384 dimer interface [polypeptide binding]; other site 1036743004385 phosphorylation site [posttranslational modification] 1036743004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743004387 ATP binding site [chemical binding]; other site 1036743004388 Mg2+ binding site [ion binding]; other site 1036743004389 G-X-G motif; other site 1036743004390 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1036743004391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004392 active site 1036743004393 phosphorylation site [posttranslational modification] 1036743004394 intermolecular recognition site; other site 1036743004395 dimerization interface [polypeptide binding]; other site 1036743004396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743004397 Walker A motif; other site 1036743004398 ATP binding site [chemical binding]; other site 1036743004399 Walker B motif; other site 1036743004400 arginine finger; other site 1036743004401 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743004402 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1036743004403 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1036743004404 ATP binding site [chemical binding]; other site 1036743004405 Mg++ binding site [ion binding]; other site 1036743004406 motif III; other site 1036743004407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743004408 nucleotide binding region [chemical binding]; other site 1036743004409 ATP-binding site [chemical binding]; other site 1036743004410 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1036743004411 RNA binding site [nucleotide binding]; other site 1036743004412 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1036743004413 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1036743004414 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1036743004415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743004416 Walker A motif; other site 1036743004417 ATP binding site [chemical binding]; other site 1036743004418 Walker B motif; other site 1036743004419 arginine finger; other site 1036743004420 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743004421 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 1036743004422 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1036743004423 putative active site pocket [active] 1036743004424 dimerization interface [polypeptide binding]; other site 1036743004425 putative catalytic residue [active] 1036743004426 Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940 1036743004427 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 1036743004428 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1036743004429 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 1036743004430 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 1036743004431 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 1036743004432 nitrogenase iron protein; Region: nifH; TIGR01287 1036743004433 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1036743004434 Nucleotide-binding sites [chemical binding]; other site 1036743004435 Switch I region of nucleotide binding site; other site 1036743004436 Fe4S4 binding sites [ion binding]; other site 1036743004437 Switch II region of nucleotide binding site; other site 1036743004438 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1036743004439 anti sigma factor interaction site; other site 1036743004440 regulatory phosphorylation site [posttranslational modification]; other site 1036743004441 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743004442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004443 active site 1036743004444 phosphorylation site [posttranslational modification] 1036743004445 intermolecular recognition site; other site 1036743004446 dimerization interface [polypeptide binding]; other site 1036743004447 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1036743004448 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1036743004449 putative binding surface; other site 1036743004450 active site 1036743004451 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1036743004452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743004453 ATP binding site [chemical binding]; other site 1036743004454 Mg2+ binding site [ion binding]; other site 1036743004455 G-X-G motif; other site 1036743004456 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1036743004457 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1036743004458 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743004459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743004460 dimerization interface [polypeptide binding]; other site 1036743004461 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743004462 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743004463 dimer interface [polypeptide binding]; other site 1036743004464 putative CheW interface [polypeptide binding]; other site 1036743004465 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1036743004466 putative CheA interaction surface; other site 1036743004467 CHASE3 domain; Region: CHASE3; cl05000 1036743004468 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743004469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743004470 dimerization interface [polypeptide binding]; other site 1036743004471 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1036743004472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743004473 dimer interface [polypeptide binding]; other site 1036743004474 putative CheW interface [polypeptide binding]; other site 1036743004475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743004476 dimerization interface [polypeptide binding]; other site 1036743004477 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743004478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743004479 dimer interface [polypeptide binding]; other site 1036743004480 putative CheW interface [polypeptide binding]; other site 1036743004481 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1036743004482 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1036743004483 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1036743004484 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1036743004485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004486 active site 1036743004487 phosphorylation site [posttranslational modification] 1036743004488 intermolecular recognition site; other site 1036743004489 dimerization interface [polypeptide binding]; other site 1036743004490 CheB methylesterase; Region: CheB_methylest; pfam01339 1036743004491 CheD chemotactic sensory transduction; Region: CheD; cl00810 1036743004492 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743004493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743004494 dimerization interface [polypeptide binding]; other site 1036743004495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743004496 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743004497 dimer interface [polypeptide binding]; other site 1036743004498 putative CheW interface [polypeptide binding]; other site 1036743004499 L-lactate permease; Provisional; Region: PRK10420 1036743004500 glycolate transporter; Provisional; Region: PRK09695 1036743004501 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743004502 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743004503 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1036743004504 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1036743004505 Cysteine-rich domain; Region: CCG; pfam02754 1036743004506 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1036743004507 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1036743004508 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1036743004509 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1036743004510 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1036743004511 Cysteine-rich domain; Region: CCG; pfam02754 1036743004512 Cysteine-rich domain; Region: CCG; pfam02754 1036743004513 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1036743004514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743004515 DNA-binding site [nucleotide binding]; DNA binding site 1036743004516 FCD domain; Region: FCD; pfam07729 1036743004517 PIN domain; Region: PIN_3; pfam13470 1036743004518 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1036743004519 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1036743004520 catalytic residue [active] 1036743004521 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1036743004522 catalytic residues [active] 1036743004523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1036743004524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743004525 peroxiredoxin; Region: AhpC; TIGR03137 1036743004526 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1036743004527 dimer interface [polypeptide binding]; other site 1036743004528 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1036743004529 catalytic triad [active] 1036743004530 peroxidatic and resolving cysteines [active] 1036743004531 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1036743004532 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743004533 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743004534 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743004535 NADH dehydrogenase; Region: NADHdh; cl00469 1036743004536 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1036743004537 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1036743004538 hydrogenase 4 subunit H; Validated; Region: PRK08222 1036743004539 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1036743004540 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1036743004541 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1036743004542 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1036743004543 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1036743004544 4Fe-4S binding domain; Region: Fer4; pfam00037 1036743004545 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 1036743004546 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 1036743004547 ACS interaction site; other site 1036743004548 CODH interaction site; other site 1036743004549 cubane metal cluster (B-cluster) [ion binding]; other site 1036743004550 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 1036743004551 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1036743004552 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1036743004553 P-loop; other site 1036743004554 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743004555 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 1036743004556 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743004557 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743004558 ligand binding site [chemical binding]; other site 1036743004559 flexible hinge region; other site 1036743004560 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1036743004561 putative switch regulator; other site 1036743004562 non-specific DNA interactions [nucleotide binding]; other site 1036743004563 DNA binding site [nucleotide binding] 1036743004564 sequence specific DNA binding site [nucleotide binding]; other site 1036743004565 putative cAMP binding site [chemical binding]; other site 1036743004566 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 1036743004567 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1036743004568 dimerization interface [polypeptide binding]; other site 1036743004569 active site 1036743004570 L-aspartate oxidase; Provisional; Region: PRK07512 1036743004571 L-aspartate oxidase; Provisional; Region: PRK06175 1036743004572 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1036743004573 quinolinate synthetase; Provisional; Region: PRK09375 1036743004574 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1036743004575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004576 active site 1036743004577 phosphorylation site [posttranslational modification] 1036743004578 intermolecular recognition site; other site 1036743004579 dimerization interface [polypeptide binding]; other site 1036743004580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743004581 Walker A motif; other site 1036743004582 ATP binding site [chemical binding]; other site 1036743004583 Walker B motif; other site 1036743004584 arginine finger; other site 1036743004585 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743004586 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1036743004587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743004588 dimer interface [polypeptide binding]; other site 1036743004589 phosphorylation site [posttranslational modification] 1036743004590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743004591 ATP binding site [chemical binding]; other site 1036743004592 Mg2+ binding site [ion binding]; other site 1036743004593 G-X-G motif; other site 1036743004594 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1036743004595 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1036743004596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743004597 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1036743004598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743004599 DNA binding residues [nucleotide binding] 1036743004600 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1036743004601 FecR protein; Region: FecR; pfam04773 1036743004602 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1036743004603 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743004604 N-terminal plug; other site 1036743004605 ligand-binding site [chemical binding]; other site 1036743004606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1036743004607 MarR family; Region: MarR_2; pfam12802 1036743004608 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1036743004609 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 1036743004610 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1036743004611 active site 1036743004612 dimer interface [polypeptide binding]; other site 1036743004613 catalytic residues [active] 1036743004614 effector binding site; other site 1036743004615 R2 peptide binding site; other site 1036743004616 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1036743004617 dimer interface [polypeptide binding]; other site 1036743004618 putative radical transfer pathway; other site 1036743004619 diiron center [ion binding]; other site 1036743004620 tyrosyl radical; other site 1036743004621 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1036743004622 dimerization interface [polypeptide binding]; other site 1036743004623 metal binding site [ion binding]; metal-binding site 1036743004624 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1036743004625 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1036743004626 P loop; other site 1036743004627 Nucleotide binding site [chemical binding]; other site 1036743004628 DTAP/Switch II; other site 1036743004629 Switch I; other site 1036743004630 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1036743004631 DTAP/Switch II; other site 1036743004632 Switch I; other site 1036743004633 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1036743004634 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1036743004635 Sodium Bile acid symporter family; Region: SBF; cl17470 1036743004636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743004637 dimerization interface [polypeptide binding]; other site 1036743004638 putative DNA binding site [nucleotide binding]; other site 1036743004639 putative Zn2+ binding site [ion binding]; other site 1036743004640 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1036743004641 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1036743004642 active site 1036743004643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1036743004644 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1036743004645 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1036743004646 Phage Tail Collar Domain; Region: Collar; pfam07484 1036743004647 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1036743004648 Phage Tail Collar Domain; Region: Collar; pfam07484 1036743004649 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1036743004650 Phage Tail Collar Domain; Region: Collar; pfam07484 1036743004651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743004652 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743004653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743004654 S-adenosylmethionine binding site [chemical binding]; other site 1036743004655 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743004656 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743004657 N-terminal plug; other site 1036743004658 ligand-binding site [chemical binding]; other site 1036743004659 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1036743004660 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743004661 Ligand Binding Site [chemical binding]; other site 1036743004662 Molecular Tunnel; other site 1036743004663 2-isopropylmalate synthase; Validated; Region: PRK03739 1036743004664 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1036743004665 active site 1036743004666 catalytic residues [active] 1036743004667 metal binding site [ion binding]; metal-binding site 1036743004668 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1036743004669 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1036743004670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743004671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743004672 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1036743004673 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1036743004674 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1036743004675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743004676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743004677 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1036743004678 putative dimerization interface [polypeptide binding]; other site 1036743004679 Acetokinase family; Region: Acetate_kinase; cl17229 1036743004680 propionate/acetate kinase; Provisional; Region: PRK12379 1036743004681 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1036743004682 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1036743004683 dimer interaction site [polypeptide binding]; other site 1036743004684 substrate-binding tunnel; other site 1036743004685 active site 1036743004686 catalytic site [active] 1036743004687 substrate binding site [chemical binding]; other site 1036743004688 phosphate acetyltransferase; Provisional; Region: PRK11890 1036743004689 putative acyltransferase; Provisional; Region: PRK05790 1036743004690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1036743004691 dimer interface [polypeptide binding]; other site 1036743004692 active site 1036743004693 Coenzyme A transferase; Region: CoA_trans; cl17247 1036743004694 Coenzyme A transferase; Region: CoA_trans; cl17247 1036743004695 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1036743004696 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1036743004697 Citrate transporter; Region: CitMHS; pfam03600 1036743004698 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1036743004699 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1036743004700 PhnA protein; Region: PhnA; pfam03831 1036743004701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743004702 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1036743004703 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1036743004704 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743004705 active site 1036743004706 dimer interface [polypeptide binding]; other site 1036743004707 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1036743004708 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743004709 Ligand Binding Site [chemical binding]; other site 1036743004710 Molecular Tunnel; other site 1036743004711 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743004712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743004713 S-adenosylmethionine binding site [chemical binding]; other site 1036743004714 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1036743004715 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1036743004716 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1036743004717 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1036743004718 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1036743004719 Right handed beta helix region; Region: Beta_helix; pfam13229 1036743004720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743004721 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1036743004722 NAD(P) binding site [chemical binding]; other site 1036743004723 active site 1036743004724 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1036743004725 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1036743004726 SLBB domain; Region: SLBB; pfam10531 1036743004727 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1036743004728 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1036743004729 active site 1036743004730 metal binding site [ion binding]; metal-binding site 1036743004731 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1036743004732 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1036743004733 Chain length determinant protein; Region: Wzz; cl15801 1036743004734 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1036743004735 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1036743004736 Nucleotide binding site [chemical binding]; other site 1036743004737 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1036743004738 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1036743004739 active site 1036743004740 homodimer interface [polypeptide binding]; other site 1036743004741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743004742 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1036743004743 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1036743004744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743004745 Walker A/P-loop; other site 1036743004746 ATP binding site [chemical binding]; other site 1036743004747 Q-loop/lid; other site 1036743004748 ABC transporter signature motif; other site 1036743004749 Walker B; other site 1036743004750 D-loop; other site 1036743004751 H-loop/switch region; other site 1036743004752 DNA starvation/stationary phase protection protein Dps; Provisional; Region: PRK09448 1036743004753 Ferritin-like domain; Region: Ferritin; pfam00210 1036743004754 CheB methylesterase; Region: CheB_methylest; pfam01339 1036743004755 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1036743004756 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1036743004757 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1036743004758 PAS domain; Region: PAS_10; pfam13596 1036743004759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743004760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743004761 ATP binding site [chemical binding]; other site 1036743004762 Mg2+ binding site [ion binding]; other site 1036743004763 G-X-G motif; other site 1036743004764 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743004765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004766 active site 1036743004767 phosphorylation site [posttranslational modification] 1036743004768 intermolecular recognition site; other site 1036743004769 dimerization interface [polypeptide binding]; other site 1036743004770 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1036743004771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743004772 active site 1036743004773 phosphorylation site [posttranslational modification] 1036743004774 intermolecular recognition site; other site 1036743004775 dimerization interface [polypeptide binding]; other site 1036743004776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743004777 dimerization interface [polypeptide binding]; other site 1036743004778 DNA binding residues [nucleotide binding] 1036743004779 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1036743004780 BON domain; Region: BON; pfam04972 1036743004781 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1036743004782 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1036743004783 putative NAD(P) binding site [chemical binding]; other site 1036743004784 putative substrate binding site [chemical binding]; other site 1036743004785 catalytic Zn binding site [ion binding]; other site 1036743004786 structural Zn binding site [ion binding]; other site 1036743004787 dimer interface [polypeptide binding]; other site 1036743004788 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1036743004789 putative active site [active] 1036743004790 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1036743004791 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1036743004792 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1036743004793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743004794 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1036743004795 NAD(P) binding site [chemical binding]; other site 1036743004796 active site 1036743004797 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1036743004798 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1036743004799 putative metal binding site; other site 1036743004800 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1036743004801 metal binding triad [ion binding]; metal-binding site 1036743004802 Protein of unknown function DUF86; Region: DUF86; cl01031 1036743004803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1036743004804 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1036743004805 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1036743004806 potential frameshift: common BLAST hit: gi|83593613|ref|YP_427365.1| transposase IS66 1036743004807 potential frameshift: common BLAST hit: gi|83593613|ref|YP_427365.1| transposase IS66 1036743004808 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743004809 DNA-binding site [nucleotide binding]; DNA binding site 1036743004810 RNA-binding motif; other site 1036743004811 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1036743004812 Hemerythrin; Region: Hemerythrin; cd12107 1036743004813 Fe binding site [ion binding]; other site 1036743004814 Hemerythrin; Region: Hemerythrin; cd12107 1036743004815 Fe binding site [ion binding]; other site 1036743004816 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1036743004817 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1036743004818 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1036743004819 dimer interface [polypeptide binding]; other site 1036743004820 active site 1036743004821 ADP-ribose binding site [chemical binding]; other site 1036743004822 nudix motif; other site 1036743004823 metal binding site [ion binding]; metal-binding site 1036743004824 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1036743004825 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743004826 P-loop; other site 1036743004827 Magnesium ion binding site [ion binding]; other site 1036743004828 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1036743004829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743004830 Walker A/P-loop; other site 1036743004831 ATP binding site [chemical binding]; other site 1036743004832 Q-loop/lid; other site 1036743004833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743004834 ABC transporter signature motif; other site 1036743004835 Walker B; other site 1036743004836 D-loop; other site 1036743004837 ABC transporter; Region: ABC_tran_2; pfam12848 1036743004838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743004839 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1036743004840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743004841 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1036743004842 putative DNA binding site [nucleotide binding]; other site 1036743004843 putative Zn2+ binding site [ion binding]; other site 1036743004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743004845 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1036743004846 S-adenosylmethionine binding site [chemical binding]; other site 1036743004847 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1036743004848 FAD binding site [chemical binding]; other site 1036743004849 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1036743004850 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1036743004851 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1036743004852 substrate binding pocket [chemical binding]; other site 1036743004853 dimer interface [polypeptide binding]; other site 1036743004854 inhibitor binding site; inhibition site 1036743004855 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1036743004856 B12 binding site [chemical binding]; other site 1036743004857 cobalt ligand [ion binding]; other site 1036743004858 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1036743004859 PET122; Region: PET122; pfam05476 1036743004860 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743004861 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1036743004862 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1036743004863 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1036743004864 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1036743004865 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1036743004866 Cl- selectivity filter; other site 1036743004867 Cl- binding residues [ion binding]; other site 1036743004868 pore gating glutamate residue; other site 1036743004869 dimer interface [polypeptide binding]; other site 1036743004870 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1036743004871 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1036743004872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743004873 non-specific DNA binding site [nucleotide binding]; other site 1036743004874 salt bridge; other site 1036743004875 sequence-specific DNA binding site [nucleotide binding]; other site 1036743004876 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1036743004877 AAR2 protein; Region: AAR2; pfam05282 1036743004878 Family description; Region: UvrD_C_2; pfam13538 1036743004879 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1036743004880 TOBE domain; Region: TOBE; cl01440 1036743004881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743004882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1036743004883 dimerization interface [polypeptide binding]; other site 1036743004884 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1036743004885 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743004886 inhibitor-cofactor binding pocket; inhibition site 1036743004887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743004888 catalytic residue [active] 1036743004889 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1036743004890 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1036743004891 tetrameric interface [polypeptide binding]; other site 1036743004892 NAD binding site [chemical binding]; other site 1036743004893 catalytic residues [active] 1036743004894 molybdenum transport protein ModD; Provisional; Region: PRK06096 1036743004895 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1036743004896 dimerization interface [polypeptide binding]; other site 1036743004897 active site 1036743004898 PAS fold; Region: PAS_7; pfam12860 1036743004899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743004900 putative active site [active] 1036743004901 heme pocket [chemical binding]; other site 1036743004902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743004903 PAS domain; Region: PAS_9; pfam13426 1036743004904 putative active site [active] 1036743004905 heme pocket [chemical binding]; other site 1036743004906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743004907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743004908 metal binding site [ion binding]; metal-binding site 1036743004909 active site 1036743004910 I-site; other site 1036743004911 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743004912 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743004913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743004914 metal binding site [ion binding]; metal-binding site 1036743004915 active site 1036743004916 I-site; other site 1036743004917 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1036743004918 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1036743004919 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1036743004920 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1036743004921 ATP binding site [chemical binding]; other site 1036743004922 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1036743004923 trigger factor; Provisional; Region: tig; PRK01490 1036743004924 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1036743004925 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1036743004926 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1036743004927 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1036743004928 oligomer interface [polypeptide binding]; other site 1036743004929 active site residues [active] 1036743004930 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1036743004931 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1036743004932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743004933 Walker A motif; other site 1036743004934 ATP binding site [chemical binding]; other site 1036743004935 Walker B motif; other site 1036743004936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1036743004937 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1036743004938 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1036743004939 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1036743004940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743004941 Walker A motif; other site 1036743004942 ATP binding site [chemical binding]; other site 1036743004943 Walker B motif; other site 1036743004944 arginine finger; other site 1036743004945 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1036743004946 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1036743004947 IHF dimer interface [polypeptide binding]; other site 1036743004948 IHF - DNA interface [nucleotide binding]; other site 1036743004949 potential protein location (hypothetical protein F11_08015 [Rhodospirillum rubrum F11]) that overlaps RNA (tRNA-V) 1036743004950 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743004951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743004952 dimer interface [polypeptide binding]; other site 1036743004953 putative CheW interface [polypeptide binding]; other site 1036743004954 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1036743004955 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1036743004956 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1036743004957 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1036743004958 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1036743004959 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1036743004960 Protein of unknown function, DUF393; Region: DUF393; cl01136 1036743004961 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1036743004962 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1036743004963 putative dimer interface [polypeptide binding]; other site 1036743004964 [2Fe-2S] cluster binding site [ion binding]; other site 1036743004965 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1036743004966 SLBB domain; Region: SLBB; pfam10531 1036743004967 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1036743004968 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1036743004969 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1036743004970 catalytic loop [active] 1036743004971 iron binding site [ion binding]; other site 1036743004972 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1036743004973 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1036743004974 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1036743004975 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1036743004976 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1036743004977 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1036743004978 4Fe-4S binding domain; Region: Fer4; pfam00037 1036743004979 4Fe-4S binding domain; Region: Fer4; pfam00037 1036743004980 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1036743004981 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1036743004982 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1036743004983 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1036743004984 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1036743004985 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1036743004986 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743004987 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1036743004988 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743004989 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196 1036743004990 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743004991 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1036743004992 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1036743004993 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1036743004994 pantothenate kinase; Reviewed; Region: PRK13318 1036743004995 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1036743004996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1036743004997 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1036743004998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1036743004999 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1036743005000 dimer interface [polypeptide binding]; other site 1036743005001 substrate binding site [chemical binding]; other site 1036743005002 metal binding site [ion binding]; metal-binding site 1036743005003 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1036743005004 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1036743005005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1036743005006 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1036743005007 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1036743005008 dimer interface [polypeptide binding]; other site 1036743005009 motif 1; other site 1036743005010 active site 1036743005011 motif 2; other site 1036743005012 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1036743005013 active site 1036743005014 motif 3; other site 1036743005015 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1036743005016 anticodon binding site; other site 1036743005017 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1036743005018 DJ-1 family protein; Region: not_thiJ; TIGR01383 1036743005019 conserved cys residue [active] 1036743005020 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1036743005021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1036743005022 FtsX-like permease family; Region: FtsX; pfam02687 1036743005023 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1036743005024 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743005025 Walker A/P-loop; other site 1036743005026 ATP binding site [chemical binding]; other site 1036743005027 Q-loop/lid; other site 1036743005028 ABC transporter signature motif; other site 1036743005029 Walker B; other site 1036743005030 D-loop; other site 1036743005031 H-loop/switch region; other site 1036743005032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1036743005033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743005034 Coenzyme A binding pocket [chemical binding]; other site 1036743005035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743005036 Coenzyme A binding pocket [chemical binding]; other site 1036743005037 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1036743005038 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1036743005039 putative active site [active] 1036743005040 putative PHP Thumb interface [polypeptide binding]; other site 1036743005041 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1036743005042 generic binding surface I; other site 1036743005043 generic binding surface II; other site 1036743005044 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743005045 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743005046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743005047 dimer interface [polypeptide binding]; other site 1036743005048 putative CheW interface [polypeptide binding]; other site 1036743005049 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743005050 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743005051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743005052 dimer interface [polypeptide binding]; other site 1036743005053 putative CheW interface [polypeptide binding]; other site 1036743005054 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1036743005055 rRNA interaction site [nucleotide binding]; other site 1036743005056 S8 interaction site; other site 1036743005057 putative laminin-1 binding site; other site 1036743005058 elongation factor Ts; Provisional; Region: tsf; PRK09377 1036743005059 UBA/TS-N domain; Region: UBA; pfam00627 1036743005060 Elongation factor TS; Region: EF_TS; pfam00889 1036743005061 Elongation factor TS; Region: EF_TS; pfam00889 1036743005062 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1036743005063 putative nucleotide binding site [chemical binding]; other site 1036743005064 uridine monophosphate binding site [chemical binding]; other site 1036743005065 homohexameric interface [polypeptide binding]; other site 1036743005066 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1036743005067 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1036743005068 hinge region; other site 1036743005069 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 1036743005070 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1036743005071 catalytic residue [active] 1036743005072 putative FPP diphosphate binding site; other site 1036743005073 putative FPP binding hydrophobic cleft; other site 1036743005074 dimer interface [polypeptide binding]; other site 1036743005075 putative IPP diphosphate binding site; other site 1036743005076 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1036743005077 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1036743005078 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1036743005079 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1036743005080 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1036743005081 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1036743005082 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1036743005083 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1036743005084 active site 1036743005085 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1036743005086 protein binding site [polypeptide binding]; other site 1036743005087 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1036743005088 putative substrate binding region [chemical binding]; other site 1036743005089 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1036743005090 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1036743005091 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1036743005092 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1036743005093 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1036743005094 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1036743005095 Surface antigen; Region: Bac_surface_Ag; pfam01103 1036743005096 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1036743005097 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1036743005098 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1036743005099 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1036743005100 active site 1036743005101 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1036743005102 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1036743005103 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1036743005104 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1036743005105 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1036743005106 dimer interface [polypeptide binding]; other site 1036743005107 active site 1036743005108 citrylCoA binding site [chemical binding]; other site 1036743005109 NADH binding [chemical binding]; other site 1036743005110 cationic pore residues; other site 1036743005111 oxalacetate/citrate binding site [chemical binding]; other site 1036743005112 coenzyme A binding site [chemical binding]; other site 1036743005113 catalytic triad [active] 1036743005114 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1036743005115 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1036743005116 HIGH motif; other site 1036743005117 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1036743005118 active site 1036743005119 KMSKS motif; other site 1036743005120 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1036743005121 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1036743005122 Competence protein; Region: Competence; pfam03772 1036743005123 PhoH-like protein; Region: PhoH; pfam02562 1036743005124 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1036743005125 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1036743005126 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1036743005127 active site 1036743005128 homodimer interface [polypeptide binding]; other site 1036743005129 catalytic site [active] 1036743005130 acceptor binding site [chemical binding]; other site 1036743005131 trehalose synthase; Region: treS_nterm; TIGR02456 1036743005132 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1036743005133 active site 1036743005134 catalytic site [active] 1036743005135 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1036743005136 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1036743005137 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1036743005138 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1036743005139 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1036743005140 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1036743005141 active site 1036743005142 catalytic site [active] 1036743005143 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1036743005144 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1036743005145 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1036743005146 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1036743005147 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1036743005148 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743005149 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1036743005150 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1036743005151 cystathionine beta-lyase; Provisional; Region: PRK09028 1036743005152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1036743005153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743005154 catalytic residue [active] 1036743005155 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 1036743005156 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1036743005157 active site residue [active] 1036743005158 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1036743005159 active site residue [active] 1036743005160 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1036743005161 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1036743005162 dimer interface [polypeptide binding]; other site 1036743005163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743005164 catalytic residue [active] 1036743005165 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1036743005166 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 1036743005167 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 1036743005168 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1036743005169 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1036743005170 FMN binding site [chemical binding]; other site 1036743005171 active site 1036743005172 catalytic residues [active] 1036743005173 substrate binding site [chemical binding]; other site 1036743005174 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743005175 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743005176 ligand binding site [chemical binding]; other site 1036743005177 flexible hinge region; other site 1036743005178 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1036743005179 non-specific DNA interactions [nucleotide binding]; other site 1036743005180 DNA binding site [nucleotide binding] 1036743005181 sequence specific DNA binding site [nucleotide binding]; other site 1036743005182 putative cAMP binding site [chemical binding]; other site 1036743005183 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1036743005184 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1036743005185 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1036743005186 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743005187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743005188 S-adenosylmethionine binding site [chemical binding]; other site 1036743005189 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 1036743005190 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1036743005191 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1036743005192 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1036743005193 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1036743005194 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743005195 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1036743005196 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743005197 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1036743005198 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1036743005199 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1036743005200 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 1036743005201 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 1036743005202 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1036743005203 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1036743005204 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1036743005205 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1036743005206 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1036743005207 NMT1/THI5 like; Region: NMT1; pfam09084 1036743005208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743005209 membrane-bound complex binding site; other site 1036743005210 hinge residues; other site 1036743005211 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1036743005212 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1036743005213 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1036743005214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743005215 Walker A/P-loop; other site 1036743005216 ATP binding site [chemical binding]; other site 1036743005217 ABC transporter signature motif; other site 1036743005218 Walker B; other site 1036743005219 D-loop; other site 1036743005220 H-loop/switch region; other site 1036743005221 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1036743005222 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1036743005223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1036743005224 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1036743005225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743005226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1036743005227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743005228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743005229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743005230 dimerization interface [polypeptide binding]; other site 1036743005231 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743005232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743005233 active site 1036743005234 phosphorylation site [posttranslational modification] 1036743005235 intermolecular recognition site; other site 1036743005236 dimerization interface [polypeptide binding]; other site 1036743005237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005238 PAS domain; Region: PAS_9; pfam13426 1036743005239 putative active site [active] 1036743005240 heme pocket [chemical binding]; other site 1036743005241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743005242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743005243 metal binding site [ion binding]; metal-binding site 1036743005244 active site 1036743005245 I-site; other site 1036743005246 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743005247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743005248 active site 1036743005249 phosphorylation site [posttranslational modification] 1036743005250 intermolecular recognition site; other site 1036743005251 dimerization interface [polypeptide binding]; other site 1036743005252 Hemerythrin; Region: Hemerythrin; cd12107 1036743005253 Fe binding site [ion binding]; other site 1036743005254 GcrA cell cycle regulator; Region: GcrA; cl11564 1036743005255 MFS_1 like family; Region: MFS_1_like; pfam12832 1036743005256 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1036743005257 acyl-CoA synthetase; Validated; Region: PRK08162 1036743005258 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1036743005259 acyl-activating enzyme (AAE) consensus motif; other site 1036743005260 putative active site [active] 1036743005261 AMP binding site [chemical binding]; other site 1036743005262 putative CoA binding site [chemical binding]; other site 1036743005263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005264 putative active site [active] 1036743005265 heme pocket [chemical binding]; other site 1036743005266 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1036743005267 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743005268 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1036743005269 Peptidase family M23; Region: Peptidase_M23; pfam01551 1036743005270 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1036743005271 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1036743005272 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1036743005273 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 1036743005274 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1036743005275 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1036743005276 putative phosphate acyltransferase; Provisional; Region: PRK05331 1036743005277 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1036743005278 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1036743005279 dimer interface [polypeptide binding]; other site 1036743005280 active site 1036743005281 CoA binding pocket [chemical binding]; other site 1036743005282 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1036743005283 IHF dimer interface [polypeptide binding]; other site 1036743005284 IHF - DNA interface [nucleotide binding]; other site 1036743005285 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1036743005286 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1036743005287 DNA binding residues [nucleotide binding] 1036743005288 PemK-like protein; Region: PemK; cl00995 1036743005289 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1036743005290 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1036743005291 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1036743005292 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1036743005293 substrate binding site; other site 1036743005294 dimer interface; other site 1036743005295 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1036743005296 homotrimer interaction site [polypeptide binding]; other site 1036743005297 zinc binding site [ion binding]; other site 1036743005298 CDP-binding sites; other site 1036743005299 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1036743005300 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1036743005301 FMN binding site [chemical binding]; other site 1036743005302 active site 1036743005303 catalytic residues [active] 1036743005304 substrate binding site [chemical binding]; other site 1036743005305 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1036743005306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005307 putative active site [active] 1036743005308 heme pocket [chemical binding]; other site 1036743005309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743005310 dimer interface [polypeptide binding]; other site 1036743005311 phosphorylation site [posttranslational modification] 1036743005312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743005313 ATP binding site [chemical binding]; other site 1036743005314 Mg2+ binding site [ion binding]; other site 1036743005315 G-X-G motif; other site 1036743005316 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1036743005317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743005318 active site 1036743005319 phosphorylation site [posttranslational modification] 1036743005320 intermolecular recognition site; other site 1036743005321 dimerization interface [polypeptide binding]; other site 1036743005322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743005323 Walker A motif; other site 1036743005324 ATP binding site [chemical binding]; other site 1036743005325 Walker B motif; other site 1036743005326 arginine finger; other site 1036743005327 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1036743005328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743005329 dimerization interface [polypeptide binding]; other site 1036743005330 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1036743005331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005332 putative active site [active] 1036743005333 heme pocket [chemical binding]; other site 1036743005334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743005335 dimer interface [polypeptide binding]; other site 1036743005336 phosphorylation site [posttranslational modification] 1036743005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743005338 ATP binding site [chemical binding]; other site 1036743005339 Mg2+ binding site [ion binding]; other site 1036743005340 G-X-G motif; other site 1036743005341 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1036743005342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743005343 active site 1036743005344 phosphorylation site [posttranslational modification] 1036743005345 intermolecular recognition site; other site 1036743005346 dimerization interface [polypeptide binding]; other site 1036743005347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743005348 Walker A motif; other site 1036743005349 ATP binding site [chemical binding]; other site 1036743005350 Walker B motif; other site 1036743005351 arginine finger; other site 1036743005352 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743005353 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1036743005354 TrkA-N domain; Region: TrkA_N; pfam02254 1036743005355 TrkA-C domain; Region: TrkA_C; pfam02080 1036743005356 TrkA-N domain; Region: TrkA_N; pfam02254 1036743005357 TrkA-C domain; Region: TrkA_C; pfam02080 1036743005358 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1036743005359 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1036743005360 homodimer interface [polypeptide binding]; other site 1036743005361 substrate-cofactor binding pocket; other site 1036743005362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743005363 catalytic residue [active] 1036743005364 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1036743005365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1036743005366 motif II; other site 1036743005367 bacterial Hfq-like; Region: Hfq; cd01716 1036743005368 hexamer interface [polypeptide binding]; other site 1036743005369 Sm1 motif; other site 1036743005370 RNA binding site [nucleotide binding]; other site 1036743005371 Sm2 motif; other site 1036743005372 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1036743005373 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1036743005374 HflX GTPase family; Region: HflX; cd01878 1036743005375 G1 box; other site 1036743005376 GTP/Mg2+ binding site [chemical binding]; other site 1036743005377 Switch I region; other site 1036743005378 G2 box; other site 1036743005379 G3 box; other site 1036743005380 Switch II region; other site 1036743005381 G4 box; other site 1036743005382 G5 box; other site 1036743005383 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1036743005384 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1036743005385 active site 1036743005386 putative lithium-binding site [ion binding]; other site 1036743005387 substrate binding site [chemical binding]; other site 1036743005388 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1036743005389 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1036743005390 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1036743005391 homodimer interface [polypeptide binding]; other site 1036743005392 metal binding site [ion binding]; metal-binding site 1036743005393 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1036743005394 homodimer interface [polypeptide binding]; other site 1036743005395 active site 1036743005396 putative chemical substrate binding site [chemical binding]; other site 1036743005397 metal binding site [ion binding]; metal-binding site 1036743005398 spermidine synthase; Provisional; Region: PRK00811 1036743005399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743005400 S-adenosylmethionine binding site [chemical binding]; other site 1036743005401 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1036743005402 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1036743005403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1036743005404 dimer interface [polypeptide binding]; other site 1036743005405 active site 1036743005406 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743005407 catalytic residues [active] 1036743005408 substrate binding site [chemical binding]; other site 1036743005409 EcsC protein family; Region: EcsC; pfam12787 1036743005410 Protein of unknown function, DUF; Region: DUF411; cl01142 1036743005411 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1036743005412 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1036743005413 putative hydrolase; Provisional; Region: PRK02113 1036743005414 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1036743005415 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1036743005416 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1036743005417 active site 1036743005418 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1036743005419 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1036743005420 active site 1036743005421 HIGH motif; other site 1036743005422 KMSKS motif; other site 1036743005423 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1036743005424 tRNA binding surface [nucleotide binding]; other site 1036743005425 anticodon binding site; other site 1036743005426 DNA polymerase III subunit delta'; Validated; Region: PRK07471 1036743005427 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1036743005428 thymidylate kinase; Validated; Region: tmk; PRK00698 1036743005429 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1036743005430 TMP-binding site; other site 1036743005431 ATP-binding site [chemical binding]; other site 1036743005432 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1036743005433 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1036743005434 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1036743005435 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1036743005436 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1036743005437 Sporulation related domain; Region: SPOR; pfam05036 1036743005438 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1036743005439 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1036743005440 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1036743005441 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1036743005442 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1036743005443 oligomeric interface; other site 1036743005444 putative active site [active] 1036743005445 homodimer interface [polypeptide binding]; other site 1036743005446 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1036743005447 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1036743005448 homotrimer interaction site [polypeptide binding]; other site 1036743005449 putative active site [active] 1036743005450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005451 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1036743005452 putative active site [active] 1036743005453 heme pocket [chemical binding]; other site 1036743005454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005455 putative active site [active] 1036743005456 heme pocket [chemical binding]; other site 1036743005457 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743005458 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743005459 dimer interface [polypeptide binding]; other site 1036743005460 putative CheW interface [polypeptide binding]; other site 1036743005461 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1036743005462 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1036743005463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743005464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743005465 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1036743005466 putative effector binding pocket; other site 1036743005467 dimerization interface [polypeptide binding]; other site 1036743005468 Predicted transporter component [General function prediction only]; Region: COG2391 1036743005469 Sulphur transport; Region: Sulf_transp; pfam04143 1036743005470 Predicted transporter component [General function prediction only]; Region: COG2391 1036743005471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743005472 dimerization interface [polypeptide binding]; other site 1036743005473 putative DNA binding site [nucleotide binding]; other site 1036743005474 putative Zn2+ binding site [ion binding]; other site 1036743005475 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1036743005476 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1036743005477 THF binding site; other site 1036743005478 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1036743005479 substrate binding site [chemical binding]; other site 1036743005480 THF binding site; other site 1036743005481 zinc-binding site [ion binding]; other site 1036743005482 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1036743005483 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1036743005484 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1036743005485 Isochorismatase family; Region: Isochorismatase; pfam00857 1036743005486 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1036743005487 catalytic triad [active] 1036743005488 conserved cis-peptide bond; other site 1036743005489 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1036743005490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1036743005491 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1036743005492 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1036743005493 potential catalytic triad [active] 1036743005494 conserved cys residue [active] 1036743005495 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1036743005496 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1036743005497 active site 1036743005498 zinc binding site [ion binding]; other site 1036743005499 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1036743005500 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1036743005501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743005502 ATP binding site [chemical binding]; other site 1036743005503 putative Mg++ binding site [ion binding]; other site 1036743005504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743005505 nucleotide binding region [chemical binding]; other site 1036743005506 ATP-binding site [chemical binding]; other site 1036743005507 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1036743005508 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1036743005509 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1036743005510 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1036743005511 ssDNA binding site; other site 1036743005512 generic binding surface II; other site 1036743005513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743005514 ATP binding site [chemical binding]; other site 1036743005515 putative Mg++ binding site [ion binding]; other site 1036743005516 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743005517 nucleotide binding region [chemical binding]; other site 1036743005518 ATP-binding site [chemical binding]; other site 1036743005519 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1036743005520 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1036743005521 Catalytic site; other site 1036743005522 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1036743005523 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1036743005524 Sporulation related domain; Region: SPOR; pfam05036 1036743005525 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1036743005526 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1036743005527 YcfA-like protein; Region: YcfA; pfam07927 1036743005528 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1036743005529 active site 1036743005530 catalytic residues [active] 1036743005531 DNA binding site [nucleotide binding] 1036743005532 Int/Topo IB signature motif; other site 1036743005533 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1036743005534 active site 1036743005535 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1036743005536 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1036743005537 active site 1036743005538 (T/H)XGH motif; other site 1036743005539 DNA gyrase subunit A; Validated; Region: PRK05560 1036743005540 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1036743005541 CAP-like domain; other site 1036743005542 active site 1036743005543 primary dimer interface [polypeptide binding]; other site 1036743005544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1036743005545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1036743005546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1036743005547 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1036743005548 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1036743005549 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1036743005550 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1036743005551 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1036743005552 dimer interface [polypeptide binding]; other site 1036743005553 ssDNA binding site [nucleotide binding]; other site 1036743005554 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1036743005555 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1036743005556 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1036743005557 dimerization interface [polypeptide binding]; other site 1036743005558 ligand binding site [chemical binding]; other site 1036743005559 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1036743005560 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1036743005561 Walker A/P-loop; other site 1036743005562 ATP binding site [chemical binding]; other site 1036743005563 Q-loop/lid; other site 1036743005564 ABC transporter signature motif; other site 1036743005565 Walker B; other site 1036743005566 D-loop; other site 1036743005567 H-loop/switch region; other site 1036743005568 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1036743005569 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1036743005570 Walker A/P-loop; other site 1036743005571 ATP binding site [chemical binding]; other site 1036743005572 Q-loop/lid; other site 1036743005573 ABC transporter signature motif; other site 1036743005574 Walker B; other site 1036743005575 D-loop; other site 1036743005576 H-loop/switch region; other site 1036743005577 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1036743005578 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1036743005579 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1036743005580 TM-ABC transporter signature motif; other site 1036743005581 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743005582 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743005583 TM-ABC transporter signature motif; other site 1036743005584 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1036743005585 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1036743005586 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1036743005587 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1036743005588 High-affinity nickel-transport protein; Region: NicO; cl00964 1036743005589 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1036743005590 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1036743005591 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1036743005592 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1036743005593 Glucose inhibited division protein A; Region: GIDA; pfam01134 1036743005594 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 1036743005595 substrate binding pocket [chemical binding]; other site 1036743005596 substrate-Mg2+ binding site; other site 1036743005597 aspartate-rich region 1; other site 1036743005598 aspartate-rich region 2; other site 1036743005599 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1036743005600 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1036743005601 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1036743005602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743005603 Coenzyme A binding pocket [chemical binding]; other site 1036743005604 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1036743005605 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1036743005606 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 1036743005607 Protein export membrane protein; Region: SecD_SecF; pfam02355 1036743005608 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1036743005609 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1036743005610 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1036743005611 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1036743005612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743005613 Walker A motif; other site 1036743005614 ATP binding site [chemical binding]; other site 1036743005615 Walker B motif; other site 1036743005616 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1036743005617 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1036743005618 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1036743005619 Peptidase family M23; Region: Peptidase_M23; pfam01551 1036743005620 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1036743005621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743005622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743005623 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1036743005624 seryl-tRNA synthetase; Provisional; Region: PRK05431 1036743005625 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1036743005626 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1036743005627 dimer interface [polypeptide binding]; other site 1036743005628 active site 1036743005629 motif 1; other site 1036743005630 motif 2; other site 1036743005631 motif 3; other site 1036743005632 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1036743005633 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1036743005634 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 1036743005635 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1036743005636 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1036743005637 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1036743005638 Peptidase family M50; Region: Peptidase_M50; pfam02163 1036743005639 active site 1036743005640 putative substrate binding region [chemical binding]; other site 1036743005641 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1036743005642 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1036743005643 Sporulation related domain; Region: SPOR; pfam05036 1036743005644 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1036743005645 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1036743005646 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1036743005647 active site 1036743005648 HIGH motif; other site 1036743005649 nucleotide binding site [chemical binding]; other site 1036743005650 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1036743005651 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1036743005652 KMSK motif region; other site 1036743005653 tRNA binding surface [nucleotide binding]; other site 1036743005654 DALR anticodon binding domain; Region: DALR_1; smart00836 1036743005655 anticodon binding site; other site 1036743005656 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1036743005657 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1036743005658 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1036743005659 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1036743005660 E-class dimer interface [polypeptide binding]; other site 1036743005661 P-class dimer interface [polypeptide binding]; other site 1036743005662 active site 1036743005663 Cu2+ binding site [ion binding]; other site 1036743005664 Zn2+ binding site [ion binding]; other site 1036743005665 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1036743005666 putative catalytic site [active] 1036743005667 putative phosphate binding site [ion binding]; other site 1036743005668 active site 1036743005669 metal binding site A [ion binding]; metal-binding site 1036743005670 DNA binding site [nucleotide binding] 1036743005671 putative AP binding site [nucleotide binding]; other site 1036743005672 putative metal binding site B [ion binding]; other site 1036743005673 Predicted membrane protein [Function unknown]; Region: COG3671 1036743005674 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1036743005675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743005676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743005677 ligand binding site [chemical binding]; other site 1036743005678 flexible hinge region; other site 1036743005679 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1036743005680 putative switch regulator; other site 1036743005681 non-specific DNA interactions [nucleotide binding]; other site 1036743005682 DNA binding site [nucleotide binding] 1036743005683 sequence specific DNA binding site [nucleotide binding]; other site 1036743005684 putative cAMP binding site [chemical binding]; other site 1036743005685 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743005686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743005687 phosphorylation site [posttranslational modification] 1036743005688 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1036743005689 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1036743005690 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1036743005691 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1036743005692 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1036743005693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1036743005694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1036743005695 Walker A/P-loop; other site 1036743005696 ATP binding site [chemical binding]; other site 1036743005697 Q-loop/lid; other site 1036743005698 ABC transporter signature motif; other site 1036743005699 Walker B; other site 1036743005700 D-loop; other site 1036743005701 H-loop/switch region; other site 1036743005702 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1036743005703 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1036743005704 Walker A/P-loop; other site 1036743005705 ATP binding site [chemical binding]; other site 1036743005706 Q-loop/lid; other site 1036743005707 ABC transporter signature motif; other site 1036743005708 Walker B; other site 1036743005709 D-loop; other site 1036743005710 H-loop/switch region; other site 1036743005711 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1036743005712 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743005713 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743005714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743005715 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1036743005716 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1036743005717 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1036743005718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743005719 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1036743005720 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1036743005721 HIGH motif; other site 1036743005722 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1036743005723 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1036743005724 active site 1036743005725 KMSKS motif; other site 1036743005726 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1036743005727 tRNA binding surface [nucleotide binding]; other site 1036743005728 anticodon binding site; other site 1036743005729 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1036743005730 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 1036743005731 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1036743005732 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1036743005733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743005734 S-adenosylmethionine binding site [chemical binding]; other site 1036743005735 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1036743005736 PAS fold; Region: PAS_3; pfam08447 1036743005737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005738 putative active site [active] 1036743005739 heme pocket [chemical binding]; other site 1036743005740 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743005741 dimer interface [polypeptide binding]; other site 1036743005742 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743005743 putative CheW interface [polypeptide binding]; other site 1036743005744 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1036743005745 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1036743005746 CoA binding domain; Region: CoA_binding_2; pfam13380 1036743005747 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1036743005748 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1036743005749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1036743005750 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1036743005751 PAS fold; Region: PAS_4; pfam08448 1036743005752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005753 putative active site [active] 1036743005754 heme pocket [chemical binding]; other site 1036743005755 PAS domain; Region: PAS_9; pfam13426 1036743005756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005757 putative active site [active] 1036743005758 heme pocket [chemical binding]; other site 1036743005759 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743005760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743005761 metal binding site [ion binding]; metal-binding site 1036743005762 active site 1036743005763 I-site; other site 1036743005764 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743005765 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1036743005766 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1036743005767 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1036743005768 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1036743005769 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743005770 ligand binding site [chemical binding]; other site 1036743005771 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1036743005772 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1036743005773 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1036743005774 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1036743005775 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1036743005776 metal binding site [ion binding]; metal-binding site 1036743005777 putative dimer interface [polypeptide binding]; other site 1036743005778 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1036743005779 putative hydrophobic ligand binding site [chemical binding]; other site 1036743005780 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1036743005781 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1036743005782 dimerization interface [polypeptide binding]; other site 1036743005783 ligand binding site [chemical binding]; other site 1036743005784 NADP binding site [chemical binding]; other site 1036743005785 catalytic site [active] 1036743005786 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1036743005787 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1036743005788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743005789 PGAP1-like protein; Region: PGAP1; pfam07819 1036743005790 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743005791 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743005792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743005793 binding surface 1036743005794 TPR motif; other site 1036743005795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743005796 vacuolar-type H(+)-translocating pyrophosphatase; Region: V_PPase; TIGR01104 1036743005797 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1036743005798 thiamine monophosphate kinase; Provisional; Region: PRK05731 1036743005799 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1036743005800 ATP binding site [chemical binding]; other site 1036743005801 dimerization interface [polypeptide binding]; other site 1036743005802 transcription antitermination factor NusB; Region: nusB; TIGR01951 1036743005803 putative RNA binding site [nucleotide binding]; other site 1036743005804 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1036743005805 homopentamer interface [polypeptide binding]; other site 1036743005806 active site 1036743005807 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1036743005808 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1036743005809 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1036743005810 dimerization interface [polypeptide binding]; other site 1036743005811 active site 1036743005812 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1036743005813 Lumazine binding domain; Region: Lum_binding; pfam00677 1036743005814 Lumazine binding domain; Region: Lum_binding; pfam00677 1036743005815 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1036743005816 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1036743005817 catalytic motif [active] 1036743005818 Zn binding site [ion binding]; other site 1036743005819 RibD C-terminal domain; Region: RibD_C; cl17279 1036743005820 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1036743005821 ATP cone domain; Region: ATP-cone; pfam03477 1036743005822 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1036743005823 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1036743005824 dimer interface [polypeptide binding]; other site 1036743005825 active site 1036743005826 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1036743005827 folate binding site [chemical binding]; other site 1036743005828 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1036743005829 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1036743005830 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1036743005831 active site 1036743005832 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1036743005833 GTP cyclohydrolase I; Provisional; Region: PLN03044 1036743005834 active site 1036743005835 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1036743005836 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1036743005837 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1036743005838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743005839 substrate binding site [chemical binding]; other site 1036743005840 oxyanion hole (OAH) forming residues; other site 1036743005841 trimer interface [polypeptide binding]; other site 1036743005842 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1036743005843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1036743005844 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1036743005845 substrate binding pocket [chemical binding]; other site 1036743005846 FAD binding site [chemical binding]; other site 1036743005847 catalytic base [active] 1036743005848 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1036743005849 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1036743005850 homodimer interface [polypeptide binding]; other site 1036743005851 substrate-cofactor binding pocket; other site 1036743005852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743005853 catalytic residue [active] 1036743005854 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1036743005855 dimer interface [polypeptide binding]; other site 1036743005856 active site 1036743005857 aspartate-rich active site metal binding site; other site 1036743005858 allosteric magnesium binding site [ion binding]; other site 1036743005859 Schiff base residues; other site 1036743005860 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743005861 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1036743005862 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1036743005863 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1036743005864 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1036743005865 active site 1036743005866 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1036743005867 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 1036743005868 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1036743005869 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1036743005870 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1036743005871 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743005872 ligand binding site [chemical binding]; other site 1036743005873 RDD family; Region: RDD; pfam06271 1036743005874 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1036743005875 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1036743005876 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1036743005877 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1036743005878 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1036743005879 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1036743005880 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1036743005881 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1036743005882 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1036743005883 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1036743005884 CAP-like domain; other site 1036743005885 active site 1036743005886 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1036743005887 Recombination protein O N terminal; Region: RecO_N; pfam11967 1036743005888 Recombination protein O C terminal; Region: RecO_C; pfam02565 1036743005889 GTPase Era; Reviewed; Region: era; PRK00089 1036743005890 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1036743005891 G1 box; other site 1036743005892 GTP/Mg2+ binding site [chemical binding]; other site 1036743005893 Switch I region; other site 1036743005894 G2 box; other site 1036743005895 Switch II region; other site 1036743005896 G3 box; other site 1036743005897 G4 box; other site 1036743005898 G5 box; other site 1036743005899 KH domain; Region: KH_2; pfam07650 1036743005900 ribonuclease III; Reviewed; Region: rnc; PRK00102 1036743005901 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1036743005902 dimerization interface [polypeptide binding]; other site 1036743005903 active site 1036743005904 metal binding site [ion binding]; metal-binding site 1036743005905 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1036743005906 dsRNA binding site [nucleotide binding]; other site 1036743005907 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1036743005908 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1036743005909 Catalytic site [active] 1036743005910 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1036743005911 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1036743005912 active site 1036743005913 hydrophilic channel; other site 1036743005914 dimerization interface [polypeptide binding]; other site 1036743005915 catalytic residues [active] 1036743005916 active site lid [active] 1036743005917 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 1036743005918 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1036743005919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1036743005920 Zn2+ binding site [ion binding]; other site 1036743005921 Mg2+ binding site [ion binding]; other site 1036743005922 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1036743005923 synthetase active site [active] 1036743005924 NTP binding site [chemical binding]; other site 1036743005925 metal binding site [ion binding]; metal-binding site 1036743005926 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1036743005927 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1036743005928 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1036743005929 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1036743005930 catalytic center binding site [active] 1036743005931 ATP binding site [chemical binding]; other site 1036743005932 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1036743005933 LabA_like proteins; Region: LabA; cd10911 1036743005934 putative metal binding site [ion binding]; other site 1036743005935 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1036743005936 Fe-S cluster binding site [ion binding]; other site 1036743005937 DNA binding site [nucleotide binding] 1036743005938 active site 1036743005939 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1036743005940 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1036743005941 catalytic residues [active] 1036743005942 dimer interface [polypeptide binding]; other site 1036743005943 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1036743005944 SmpB-tmRNA interface; other site 1036743005945 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1036743005946 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1036743005947 dimer interface [polypeptide binding]; other site 1036743005948 active site 1036743005949 catalytic residue [active] 1036743005950 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1036743005951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1036743005952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1036743005953 catalytic residue [active] 1036743005954 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1036743005955 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1036743005956 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1036743005957 Peptidase family M23; Region: Peptidase_M23; pfam01551 1036743005958 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1036743005959 tetramer interfaces [polypeptide binding]; other site 1036743005960 binuclear metal-binding site [ion binding]; other site 1036743005961 Competence-damaged protein; Region: CinA; pfam02464 1036743005962 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1036743005963 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1036743005964 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1036743005965 PhoU domain; Region: PhoU; pfam01895 1036743005966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743005967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743005968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1036743005969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743005970 PAS fold; Region: PAS_3; pfam08447 1036743005971 putative active site [active] 1036743005972 heme pocket [chemical binding]; other site 1036743005973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743005974 dimer interface [polypeptide binding]; other site 1036743005975 phosphorylation site [posttranslational modification] 1036743005976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743005977 ATP binding site [chemical binding]; other site 1036743005978 Mg2+ binding site [ion binding]; other site 1036743005979 G-X-G motif; other site 1036743005980 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1036743005981 putative coenzyme Q binding site [chemical binding]; other site 1036743005982 lipoyl synthase; Provisional; Region: PRK05481 1036743005983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743005984 FeS/SAM binding site; other site 1036743005985 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1036743005986 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1036743005987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743005988 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1036743005989 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1036743005990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1036743005991 E3 interaction surface; other site 1036743005992 lipoyl attachment site [posttranslational modification]; other site 1036743005993 e3 binding domain; Region: E3_binding; pfam02817 1036743005994 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1036743005995 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1036743005996 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1036743005997 E3 interaction surface; other site 1036743005998 lipoyl attachment site [posttranslational modification]; other site 1036743005999 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1036743006000 alpha subunit interface [polypeptide binding]; other site 1036743006001 TPP binding site [chemical binding]; other site 1036743006002 heterodimer interface [polypeptide binding]; other site 1036743006003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1036743006004 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1036743006005 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1036743006006 tetramer interface [polypeptide binding]; other site 1036743006007 TPP-binding site [chemical binding]; other site 1036743006008 heterodimer interface [polypeptide binding]; other site 1036743006009 phosphorylation loop region [posttranslational modification] 1036743006010 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1036743006011 Septum formation initiator; Region: DivIC; pfam04977 1036743006012 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1036743006013 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1036743006014 Cl binding site [ion binding]; other site 1036743006015 oligomer interface [polypeptide binding]; other site 1036743006016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743006017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743006018 dimer interface [polypeptide binding]; other site 1036743006019 phosphorylation site [posttranslational modification] 1036743006020 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1036743006021 ATP binding site [chemical binding]; other site 1036743006022 Mg2+ binding site [ion binding]; other site 1036743006023 G-X-G motif; other site 1036743006024 enolase; Provisional; Region: eno; PRK00077 1036743006025 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1036743006026 dimer interface [polypeptide binding]; other site 1036743006027 metal binding site [ion binding]; metal-binding site 1036743006028 substrate binding pocket [chemical binding]; other site 1036743006029 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1036743006030 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1036743006031 CTP synthetase; Validated; Region: pyrG; PRK05380 1036743006032 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1036743006033 Catalytic site [active] 1036743006034 active site 1036743006035 UTP binding site [chemical binding]; other site 1036743006036 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1036743006037 active site 1036743006038 putative oxyanion hole; other site 1036743006039 catalytic triad [active] 1036743006040 Preprotein translocase SecG subunit; Region: SecG; cl09123 1036743006041 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1036743006042 triosephosphate isomerase; Provisional; Region: PRK14565 1036743006043 substrate binding site [chemical binding]; other site 1036743006044 dimer interface [polypeptide binding]; other site 1036743006045 catalytic triad [active] 1036743006046 periplasmic folding chaperone; Provisional; Region: PRK10788 1036743006047 SurA N-terminal domain; Region: SurA_N_3; cl07813 1036743006048 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1036743006049 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1036743006050 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1036743006051 anthranilate synthase component I; Provisional; Region: PRK13573 1036743006052 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1036743006053 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1036743006054 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1036743006055 metal-binding site [ion binding] 1036743006056 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1036743006057 NodB motif; other site 1036743006058 putative active site [active] 1036743006059 putative catalytic site [active] 1036743006060 Zn binding site [ion binding]; other site 1036743006061 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1036743006062 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1036743006063 metal-binding site [ion binding] 1036743006064 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1036743006065 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1036743006066 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1036743006067 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1036743006068 glutamine binding [chemical binding]; other site 1036743006069 catalytic triad [active] 1036743006070 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1036743006071 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1036743006072 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1036743006073 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1036743006074 active site 1036743006075 ribulose/triose binding site [chemical binding]; other site 1036743006076 phosphate binding site [ion binding]; other site 1036743006077 substrate (anthranilate) binding pocket [chemical binding]; other site 1036743006078 product (indole) binding pocket [chemical binding]; other site 1036743006079 LexA repressor; Validated; Region: PRK00215 1036743006080 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1036743006081 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1036743006082 Catalytic site [active] 1036743006083 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 1036743006084 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743006085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743006086 putative DNA binding site [nucleotide binding]; other site 1036743006087 putative Zn2+ binding site [ion binding]; other site 1036743006088 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743006089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743006090 dimerization interface [polypeptide binding]; other site 1036743006091 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743006092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743006093 dimer interface [polypeptide binding]; other site 1036743006094 putative CheW interface [polypeptide binding]; other site 1036743006095 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1036743006096 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1036743006097 putative ligand binding site [chemical binding]; other site 1036743006098 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743006099 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1036743006100 TM-ABC transporter signature motif; other site 1036743006101 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1036743006102 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743006103 TM-ABC transporter signature motif; other site 1036743006104 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1036743006105 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1036743006106 Walker A/P-loop; other site 1036743006107 ATP binding site [chemical binding]; other site 1036743006108 Q-loop/lid; other site 1036743006109 ABC transporter signature motif; other site 1036743006110 Walker B; other site 1036743006111 D-loop; other site 1036743006112 H-loop/switch region; other site 1036743006113 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1036743006114 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1036743006115 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1036743006116 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1036743006117 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1036743006118 SelR domain; Region: SelR; pfam01641 1036743006119 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743006120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1036743006121 active site 1036743006122 phosphorylation site [posttranslational modification] 1036743006123 intermolecular recognition site; other site 1036743006124 PAS domain S-box; Region: sensory_box; TIGR00229 1036743006125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1036743006126 putative active site [active] 1036743006127 heme pocket [chemical binding]; other site 1036743006128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743006129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743006130 metal binding site [ion binding]; metal-binding site 1036743006131 active site 1036743006132 I-site; other site 1036743006133 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1036743006134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743006135 S-adenosylmethionine binding site [chemical binding]; other site 1036743006136 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1036743006137 metal binding site 2 [ion binding]; metal-binding site 1036743006138 putative DNA binding helix; other site 1036743006139 metal binding site 1 [ion binding]; metal-binding site 1036743006140 structural Zn2+ binding site [ion binding]; other site 1036743006141 oxidoreductase; Validated; Region: PRK05717 1036743006142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743006143 NAD(P) binding site [chemical binding]; other site 1036743006144 active site 1036743006145 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743006146 DNA-binding site [nucleotide binding]; DNA binding site 1036743006147 RNA-binding motif; other site 1036743006148 helicase 45; Provisional; Region: PTZ00424 1036743006149 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1036743006150 ATP binding site [chemical binding]; other site 1036743006151 Mg++ binding site [ion binding]; other site 1036743006152 motif III; other site 1036743006153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743006154 nucleotide binding region [chemical binding]; other site 1036743006155 ATP-binding site [chemical binding]; other site 1036743006156 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1036743006157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1036743006158 catalytic loop [active] 1036743006159 iron binding site [ion binding]; other site 1036743006160 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743006161 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1036743006162 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1036743006163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006164 dimer interface [polypeptide binding]; other site 1036743006165 conserved gate region; other site 1036743006166 putative PBP binding loops; other site 1036743006167 ABC-ATPase subunit interface; other site 1036743006168 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1036743006169 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1036743006170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006171 dimer interface [polypeptide binding]; other site 1036743006172 conserved gate region; other site 1036743006173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1036743006174 ABC-ATPase subunit interface; other site 1036743006175 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1036743006176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743006177 Walker A/P-loop; other site 1036743006178 ATP binding site [chemical binding]; other site 1036743006179 Q-loop/lid; other site 1036743006180 ABC transporter signature motif; other site 1036743006181 Walker B; other site 1036743006182 D-loop; other site 1036743006183 H-loop/switch region; other site 1036743006184 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743006185 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1036743006186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743006187 Walker A/P-loop; other site 1036743006188 ATP binding site [chemical binding]; other site 1036743006189 Q-loop/lid; other site 1036743006190 ABC transporter signature motif; other site 1036743006191 Walker B; other site 1036743006192 D-loop; other site 1036743006193 H-loop/switch region; other site 1036743006194 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1036743006195 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1036743006196 catalytic residues [active] 1036743006197 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1036743006198 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1036743006199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743006200 DNA-binding site [nucleotide binding]; DNA binding site 1036743006201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743006202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743006203 homodimer interface [polypeptide binding]; other site 1036743006204 catalytic residue [active] 1036743006205 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1036743006206 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1036743006207 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1036743006208 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1036743006209 2-isopropylmalate synthase; Validated; Region: PRK03739 1036743006210 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1036743006211 active site 1036743006212 catalytic residues [active] 1036743006213 metal binding site [ion binding]; metal-binding site 1036743006214 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1036743006215 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1036743006216 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1036743006217 Active Sites [active] 1036743006218 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1036743006219 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1036743006220 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1036743006221 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1036743006222 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 1036743006223 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1036743006224 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1036743006225 active site 1036743006226 SAM binding site [chemical binding]; other site 1036743006227 homodimer interface [polypeptide binding]; other site 1036743006228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743006229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743006230 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1036743006231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743006232 DNA binding residues [nucleotide binding] 1036743006233 dimerization interface [polypeptide binding]; other site 1036743006234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1036743006235 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1036743006236 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1036743006237 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1036743006238 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1036743006239 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1036743006240 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1036743006241 pseudouridine synthase; Region: TIGR00093 1036743006242 probable active site [active] 1036743006243 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1036743006244 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1036743006245 active site 1036743006246 catalytic residues [active] 1036743006247 metal binding site [ion binding]; metal-binding site 1036743006248 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1036743006249 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743006250 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1036743006251 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1036743006252 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743006253 carboxyltransferase (CT) interaction site; other site 1036743006254 biotinylation site [posttranslational modification]; other site 1036743006255 enoyl-CoA hydratase; Provisional; Region: PRK05995 1036743006256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743006257 substrate binding site [chemical binding]; other site 1036743006258 oxyanion hole (OAH) forming residues; other site 1036743006259 trimer interface [polypeptide binding]; other site 1036743006260 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1036743006261 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1036743006262 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1036743006263 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1036743006264 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1036743006265 putative catalytic residue [active] 1036743006266 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1036743006267 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1036743006268 NADP binding site [chemical binding]; other site 1036743006269 homodimer interface [polypeptide binding]; other site 1036743006270 active site 1036743006271 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1036743006272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1036743006273 dimer interface [polypeptide binding]; other site 1036743006274 active site 1036743006275 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1036743006276 isovaleryl-CoA dehydrogenase; Region: PLN02519 1036743006277 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1036743006278 substrate binding site [chemical binding]; other site 1036743006279 FAD binding site [chemical binding]; other site 1036743006280 catalytic base [active] 1036743006281 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1036743006282 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1036743006283 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1036743006284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743006285 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1036743006286 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1036743006287 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743006288 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1036743006289 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743006290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743006291 active site 1036743006292 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1036743006293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743006294 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1036743006295 Ligand Binding Site [chemical binding]; other site 1036743006296 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1036743006297 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1036743006298 active site 1036743006299 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1036743006300 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1036743006301 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1036743006302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743006303 S-adenosylmethionine binding site [chemical binding]; other site 1036743006304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743006305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743006306 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1036743006307 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1036743006308 adenylosuccinate lyase; Provisional; Region: PRK07492 1036743006309 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1036743006310 tetramer interface [polypeptide binding]; other site 1036743006311 active site 1036743006312 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1036743006313 adenylosuccinate synthetase; Provisional; Region: PRK04293 1036743006314 adenylosuccinate synthase; Region: purA; TIGR00184 1036743006315 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1036743006316 Peptidase S8 family domain, uncharacterized subfamily 10; Region: Peptidases_S8_10; cd07494 1036743006317 active site 1036743006318 catalytic triad [active] 1036743006319 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1036743006320 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1036743006321 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1036743006322 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1036743006323 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1036743006324 active site 1036743006325 P-loop; other site 1036743006326 phosphorylation site [posttranslational modification] 1036743006327 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1036743006328 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1036743006329 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1036743006330 putative substrate binding site [chemical binding]; other site 1036743006331 putative ATP binding site [chemical binding]; other site 1036743006332 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1036743006333 active site 1036743006334 phosphorylation site [posttranslational modification] 1036743006335 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1036743006336 dimerization domain swap beta strand [polypeptide binding]; other site 1036743006337 regulatory protein interface [polypeptide binding]; other site 1036743006338 active site 1036743006339 regulatory phosphorylation site [posttranslational modification]; other site 1036743006340 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1036743006341 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1036743006342 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1036743006343 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1036743006344 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1036743006345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1036743006346 DNA binding site [nucleotide binding] 1036743006347 domain linker motif; other site 1036743006348 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 1036743006349 putative dimerization interface [polypeptide binding]; other site 1036743006350 putative ligand binding site [chemical binding]; other site 1036743006351 HipA N-terminal domain; Region: Couple_hipA; cl11853 1036743006352 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1036743006353 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1036743006354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743006355 non-specific DNA binding site [nucleotide binding]; other site 1036743006356 salt bridge; other site 1036743006357 sequence-specific DNA binding site [nucleotide binding]; other site 1036743006358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1036743006359 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1036743006360 acyl-activating enzyme (AAE) consensus motif; other site 1036743006361 AMP binding site [chemical binding]; other site 1036743006362 active site 1036743006363 CoA binding site [chemical binding]; other site 1036743006364 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1036743006365 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1036743006366 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1036743006367 dimer interface [polypeptide binding]; other site 1036743006368 PYR/PP interface [polypeptide binding]; other site 1036743006369 TPP binding site [chemical binding]; other site 1036743006370 substrate binding site [chemical binding]; other site 1036743006371 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1036743006372 TPP-binding site; other site 1036743006373 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1036743006374 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1036743006375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743006376 catalytic residue [active] 1036743006377 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1036743006378 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1036743006379 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1036743006380 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1036743006381 active site 1036743006382 Zn binding site [ion binding]; other site 1036743006383 hypothetical protein; Provisional; Region: PRK01842 1036743006384 SEC-C motif; Region: SEC-C; pfam02810 1036743006385 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 1036743006386 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 1036743006387 Abi-like protein; Region: Abi_2; pfam07751 1036743006388 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1036743006389 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1036743006390 putative oligomer interface [polypeptide binding]; other site 1036743006391 putative active site [active] 1036743006392 metal binding site [ion binding]; metal-binding site 1036743006393 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1036743006394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743006395 Coenzyme A binding pocket [chemical binding]; other site 1036743006396 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1036743006397 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1036743006398 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743006399 dimer interface [polypeptide binding]; other site 1036743006400 active site 1036743006401 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743006402 Ligand Binding Site [chemical binding]; other site 1036743006403 Molecular Tunnel; other site 1036743006404 TIGR02588 family protein; Region: TIGR02588 1036743006405 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 1036743006406 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1036743006407 ArsC family; Region: ArsC; pfam03960 1036743006408 catalytic residues [active] 1036743006409 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1036743006410 putative active site [active] 1036743006411 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1036743006412 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1036743006413 DNA binding residues [nucleotide binding] 1036743006414 putative dimer interface [polypeptide binding]; other site 1036743006415 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1036743006416 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1036743006417 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1036743006418 Divalent cation transporter; Region: MgtE; pfam01769 1036743006419 lipoate-protein ligase B; Provisional; Region: PRK14341 1036743006420 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1036743006421 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1036743006422 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1036743006423 Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210 1036743006424 dimer interface [polypeptide binding]; other site 1036743006425 active site 1036743006426 catalytic residue [active] 1036743006427 metal binding site [ion binding]; metal-binding site 1036743006428 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1036743006429 Protein of unknown function (DUF497); Region: DUF497; cl01108 1036743006430 Cupin domain; Region: Cupin_2; pfam07883 1036743006431 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 1036743006432 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1036743006433 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1036743006434 putative ligand binding site [chemical binding]; other site 1036743006435 NAD binding site [chemical binding]; other site 1036743006436 dimerization interface [polypeptide binding]; other site 1036743006437 catalytic site [active] 1036743006438 hypothetical protein; Provisional; Region: PRK01254 1036743006439 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1036743006440 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1036743006441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743006442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743006443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1036743006444 dimerization interface [polypeptide binding]; other site 1036743006445 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1036743006446 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1036743006447 FAD binding site [chemical binding]; other site 1036743006448 substrate binding pocket [chemical binding]; other site 1036743006449 catalytic base [active] 1036743006450 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1036743006451 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1036743006452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1036743006453 EamA-like transporter family; Region: EamA; pfam00892 1036743006454 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1036743006455 ThiC-associated domain; Region: ThiC-associated; pfam13667 1036743006456 ThiC family; Region: ThiC; pfam01964 1036743006457 glycerol kinase; Provisional; Region: glpK; PRK00047 1036743006458 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1036743006459 N- and C-terminal domain interface [polypeptide binding]; other site 1036743006460 active site 1036743006461 MgATP binding site [chemical binding]; other site 1036743006462 catalytic site [active] 1036743006463 metal binding site [ion binding]; metal-binding site 1036743006464 glycerol binding site [chemical binding]; other site 1036743006465 homotetramer interface [polypeptide binding]; other site 1036743006466 homodimer interface [polypeptide binding]; other site 1036743006467 FBP binding site [chemical binding]; other site 1036743006468 protein IIAGlc interface [polypeptide binding]; other site 1036743006469 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1036743006470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743006471 catalytic residue [active] 1036743006472 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1036743006473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743006474 Walker A/P-loop; other site 1036743006475 ATP binding site [chemical binding]; other site 1036743006476 Q-loop/lid; other site 1036743006477 ABC transporter signature motif; other site 1036743006478 Walker B; other site 1036743006479 D-loop; other site 1036743006480 H-loop/switch region; other site 1036743006481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743006482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743006483 Walker A/P-loop; other site 1036743006484 ATP binding site [chemical binding]; other site 1036743006485 Q-loop/lid; other site 1036743006486 ABC transporter signature motif; other site 1036743006487 Walker B; other site 1036743006488 D-loop; other site 1036743006489 H-loop/switch region; other site 1036743006490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1036743006491 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1036743006492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006493 dimer interface [polypeptide binding]; other site 1036743006494 conserved gate region; other site 1036743006495 putative PBP binding loops; other site 1036743006496 ABC-ATPase subunit interface; other site 1036743006497 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1036743006498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006499 dimer interface [polypeptide binding]; other site 1036743006500 conserved gate region; other site 1036743006501 putative PBP binding loops; other site 1036743006502 ABC-ATPase subunit interface; other site 1036743006503 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743006504 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1036743006505 chaperone protein DnaJ; Provisional; Region: PRK14299 1036743006506 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1036743006507 HSP70 interaction site [polypeptide binding]; other site 1036743006508 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1036743006509 substrate binding site [polypeptide binding]; other site 1036743006510 dimer interface [polypeptide binding]; other site 1036743006511 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1036743006512 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1036743006513 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1036743006514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743006515 non-specific DNA binding site [nucleotide binding]; other site 1036743006516 salt bridge; other site 1036743006517 sequence-specific DNA binding site [nucleotide binding]; other site 1036743006518 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1036743006519 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1036743006520 putative catalytic site [active] 1036743006521 putative metal binding site [ion binding]; other site 1036743006522 putative phosphate binding site [ion binding]; other site 1036743006523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743006524 dimerization interface [polypeptide binding]; other site 1036743006525 PAS domain; Region: PAS_9; pfam13426 1036743006526 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743006527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743006528 dimer interface [polypeptide binding]; other site 1036743006529 putative CheW interface [polypeptide binding]; other site 1036743006530 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1036743006531 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1036743006532 Ligand Binding Site [chemical binding]; other site 1036743006533 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1036743006534 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1036743006535 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1036743006536 catalytic loop [active] 1036743006537 iron binding site [ion binding]; other site 1036743006538 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1036743006539 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1036743006540 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743006541 catalytic residue [active] 1036743006542 Transcriptional regulator; Region: Rrf2; cl17282 1036743006543 Rrf2 family protein; Region: rrf2_super; TIGR00738 1036743006544 serine O-acetyltransferase; Region: cysE; TIGR01172 1036743006545 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1036743006546 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1036743006547 trimer interface [polypeptide binding]; other site 1036743006548 active site 1036743006549 substrate binding site [chemical binding]; other site 1036743006550 CoA binding site [chemical binding]; other site 1036743006551 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1036743006552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1036743006553 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1036743006554 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1036743006555 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1036743006556 active site 1036743006557 HIGH motif; other site 1036743006558 dimer interface [polypeptide binding]; other site 1036743006559 KMSKS motif; other site 1036743006560 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743006561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743006562 putative active site [active] 1036743006563 heme pocket [chemical binding]; other site 1036743006564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743006565 dimer interface [polypeptide binding]; other site 1036743006566 phosphorylation site [posttranslational modification] 1036743006567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743006568 ATP binding site [chemical binding]; other site 1036743006569 Mg2+ binding site [ion binding]; other site 1036743006570 G-X-G motif; other site 1036743006571 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743006572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743006573 active site 1036743006574 phosphorylation site [posttranslational modification] 1036743006575 intermolecular recognition site; other site 1036743006576 dimerization interface [polypeptide binding]; other site 1036743006577 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1036743006578 Phosphate transporter family; Region: PHO4; pfam01384 1036743006579 PBP superfamily domain; Region: PBP_like_2; cl17296 1036743006580 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1036743006581 Protein of unknown function; Region: DUF3971; pfam13116 1036743006582 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1036743006583 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 1036743006584 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1036743006585 metal binding triad; other site 1036743006586 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1036743006587 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1036743006588 metal binding triad; other site 1036743006589 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1036743006590 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1036743006591 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1036743006592 catalytic triad [active] 1036743006593 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1036743006594 peptide chain release factor 2; Provisional; Region: PRK07342 1036743006595 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1036743006596 RF-1 domain; Region: RF-1; pfam00472 1036743006597 aminotransferase; Provisional; Region: PRK06105 1036743006598 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743006599 inhibitor-cofactor binding pocket; inhibition site 1036743006600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743006601 catalytic residue [active] 1036743006602 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1036743006603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743006604 non-specific DNA binding site [nucleotide binding]; other site 1036743006605 salt bridge; other site 1036743006606 sequence-specific DNA binding site [nucleotide binding]; other site 1036743006607 Cupin domain; Region: Cupin_2; pfam07883 1036743006608 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743006609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006610 dimer interface [polypeptide binding]; other site 1036743006611 conserved gate region; other site 1036743006612 putative PBP binding loops; other site 1036743006613 ABC-ATPase subunit interface; other site 1036743006614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006615 dimer interface [polypeptide binding]; other site 1036743006616 conserved gate region; other site 1036743006617 putative PBP binding loops; other site 1036743006618 ABC-ATPase subunit interface; other site 1036743006619 potential frameshift: common BLAST hit: gi|83593382|ref|YP_427134.1| extracellular solute-binding protein 1036743006620 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1036743006621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743006622 Walker A/P-loop; other site 1036743006623 ATP binding site [chemical binding]; other site 1036743006624 Q-loop/lid; other site 1036743006625 ABC transporter signature motif; other site 1036743006626 Walker B; other site 1036743006627 D-loop; other site 1036743006628 H-loop/switch region; other site 1036743006629 TOBE domain; Region: TOBE_2; pfam08402 1036743006630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743006631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743006632 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1036743006633 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743006634 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743006635 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743006636 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1036743006637 Protein export membrane protein; Region: SecD_SecF; cl14618 1036743006638 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1036743006639 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1036743006640 Flavoprotein; Region: Flavoprotein; pfam02441 1036743006641 Hpt domain; Region: Hpt; pfam01627 1036743006642 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1036743006643 oligomer interface [polypeptide binding]; other site 1036743006644 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1036743006645 tandem repeat interface [polypeptide binding]; other site 1036743006646 active site residues [active] 1036743006647 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1036743006648 active site clefts [active] 1036743006649 zinc binding site [ion binding]; other site 1036743006650 dimer interface [polypeptide binding]; other site 1036743006651 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1036743006652 Walker A motif; other site 1036743006653 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1036743006654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743006655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743006656 dimer interface [polypeptide binding]; other site 1036743006657 phosphorylation site [posttranslational modification] 1036743006658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743006659 ATP binding site [chemical binding]; other site 1036743006660 G-X-G motif; other site 1036743006661 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1036743006662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1036743006663 Zn2+ binding site [ion binding]; other site 1036743006664 Mg2+ binding site [ion binding]; other site 1036743006665 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743006666 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743006667 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1036743006668 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1036743006669 PRC-barrel domain; Region: PRC; pfam05239 1036743006670 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1036743006671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743006672 DNA-binding site [nucleotide binding]; DNA binding site 1036743006673 FCD domain; Region: FCD; pfam07729 1036743006674 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1036743006675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743006676 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1036743006677 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1036743006678 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1036743006679 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1036743006680 inhibitor site; inhibition site 1036743006681 active site 1036743006682 dimer interface [polypeptide binding]; other site 1036743006683 catalytic residue [active] 1036743006684 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1036743006685 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1036743006686 active site 1036743006687 dimer interfaces [polypeptide binding]; other site 1036743006688 catalytic residues [active] 1036743006689 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 1036743006690 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1036743006691 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1036743006692 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1036743006693 tetrameric interface [polypeptide binding]; other site 1036743006694 NAD binding site [chemical binding]; other site 1036743006695 catalytic residues [active] 1036743006696 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1036743006697 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1036743006698 dimer interface [polypeptide binding]; other site 1036743006699 anticodon binding site; other site 1036743006700 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1036743006701 homodimer interface [polypeptide binding]; other site 1036743006702 motif 1; other site 1036743006703 active site 1036743006704 motif 2; other site 1036743006705 GAD domain; Region: GAD; pfam02938 1036743006706 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1036743006707 active site 1036743006708 motif 3; other site 1036743006709 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1036743006710 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1036743006711 catalytic site [active] 1036743006712 putative active site [active] 1036743006713 putative substrate binding site [chemical binding]; other site 1036743006714 HRDC domain; Region: HRDC; pfam00570 1036743006715 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1036743006716 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1036743006717 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1036743006718 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 1036743006719 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1036743006720 homodimer interface [polypeptide binding]; other site 1036743006721 substrate-cofactor binding pocket; other site 1036743006722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743006723 catalytic residue [active] 1036743006724 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743006725 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743006726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743006727 dimer interface [polypeptide binding]; other site 1036743006728 putative CheW interface [polypeptide binding]; other site 1036743006729 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1036743006730 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1036743006731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743006732 dimer interface [polypeptide binding]; other site 1036743006733 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1036743006734 putative CheW interface [polypeptide binding]; other site 1036743006735 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1036743006736 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1036743006737 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1036743006738 Hemerythrin; Region: Hemerythrin; cd12107 1036743006739 Fe binding site [ion binding]; other site 1036743006740 CreA protein; Region: CreA; pfam05981 1036743006741 hypothetical protein; Provisional; Region: PRK08912 1036743006742 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743006743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743006744 homodimer interface [polypeptide binding]; other site 1036743006745 catalytic residue [active] 1036743006746 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1036743006747 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1036743006748 glutamine synthetase; Provisional; Region: glnA; PRK09469 1036743006749 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1036743006750 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1036743006751 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1036743006752 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743006753 substrate binding pocket [chemical binding]; other site 1036743006754 membrane-bound complex binding site; other site 1036743006755 hinge residues; other site 1036743006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006757 dimer interface [polypeptide binding]; other site 1036743006758 conserved gate region; other site 1036743006759 putative PBP binding loops; other site 1036743006760 ABC-ATPase subunit interface; other site 1036743006761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743006762 dimer interface [polypeptide binding]; other site 1036743006763 conserved gate region; other site 1036743006764 putative PBP binding loops; other site 1036743006765 ABC-ATPase subunit interface; other site 1036743006766 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1036743006767 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1036743006768 Walker A/P-loop; other site 1036743006769 ATP binding site [chemical binding]; other site 1036743006770 Q-loop/lid; other site 1036743006771 ABC transporter signature motif; other site 1036743006772 Walker B; other site 1036743006773 D-loop; other site 1036743006774 H-loop/switch region; other site 1036743006775 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1036743006776 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1036743006777 Protein export membrane protein; Region: SecD_SecF; cl14618 1036743006778 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743006779 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743006780 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743006781 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1036743006782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1036743006783 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1036743006784 PAS domain; Region: PAS_5; pfam07310 1036743006785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 1036743006786 Family of unknown function (DUF490); Region: DUF490; pfam04357 1036743006787 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1036743006788 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1036743006789 Surface antigen; Region: Bac_surface_Ag; pfam01103 1036743006790 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1036743006791 potential frameshift: common BLAST hit: gi|83593436|ref|YP_427188.1| two component, sigma54 specific, Fis family transcriptional 1036743006792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743006793 intermolecular recognition site; other site 1036743006794 active site 1036743006795 dimerization interface [polypeptide binding]; other site 1036743006796 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1036743006797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743006798 Walker A motif; other site 1036743006799 ATP binding site [chemical binding]; other site 1036743006800 Walker B motif; other site 1036743006801 arginine finger; other site 1036743006802 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743006803 cheY-homologous receiver domain; Region: REC; smart00448 1036743006804 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1036743006805 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1036743006806 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1036743006807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743006808 Walker A/P-loop; other site 1036743006809 ATP binding site [chemical binding]; other site 1036743006810 Q-loop/lid; other site 1036743006811 ABC transporter signature motif; other site 1036743006812 Walker B; other site 1036743006813 D-loop; other site 1036743006814 H-loop/switch region; other site 1036743006815 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1036743006816 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743006817 TM-ABC transporter signature motif; other site 1036743006818 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1036743006819 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1036743006820 zinc binding site [ion binding]; other site 1036743006821 putative ligand binding site [chemical binding]; other site 1036743006822 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1036743006823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743006824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743006825 dimer interface [polypeptide binding]; other site 1036743006826 phosphorylation site [posttranslational modification] 1036743006827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743006828 ATP binding site [chemical binding]; other site 1036743006829 Mg2+ binding site [ion binding]; other site 1036743006830 G-X-G motif; other site 1036743006831 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743006832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743006833 active site 1036743006834 phosphorylation site [posttranslational modification] 1036743006835 intermolecular recognition site; other site 1036743006836 dimerization interface [polypeptide binding]; other site 1036743006837 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1036743006838 putative binding surface; other site 1036743006839 active site 1036743006840 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1036743006841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743006842 Walker A motif; other site 1036743006843 ATP binding site [chemical binding]; other site 1036743006844 Walker B motif; other site 1036743006845 arginine finger; other site 1036743006846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743006847 Walker A motif; other site 1036743006848 ATP binding site [chemical binding]; other site 1036743006849 Walker B motif; other site 1036743006850 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1036743006851 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1036743006852 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1036743006853 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1036743006854 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1036743006855 phosphoglucomutase; Region: PLN02307 1036743006856 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1036743006857 substrate binding site [chemical binding]; other site 1036743006858 dimer interface [polypeptide binding]; other site 1036743006859 active site 1036743006860 metal binding site [ion binding]; metal-binding site 1036743006861 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1036743006862 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1036743006863 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1036743006864 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1036743006865 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1036743006866 active site 1036743006867 tetramer interface; other site 1036743006868 ATPase MipZ; Region: MipZ; pfam09140 1036743006869 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743006870 P-loop; other site 1036743006871 Magnesium ion binding site [ion binding]; other site 1036743006872 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743006873 Magnesium ion binding site [ion binding]; other site 1036743006874 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1036743006875 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1036743006876 putative [4Fe-4S] binding site [ion binding]; other site 1036743006877 putative molybdopterin cofactor binding site [chemical binding]; other site 1036743006878 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1036743006879 putative molybdopterin cofactor binding site; other site 1036743006880 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1036743006881 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743006882 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1036743006883 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743006884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743006885 S-adenosylmethionine binding site [chemical binding]; other site 1036743006886 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1036743006887 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1036743006888 Ligand binding site; other site 1036743006889 Putative Catalytic site; other site 1036743006890 DXD motif; other site 1036743006891 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1036743006892 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1036743006893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1036743006894 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1036743006895 malonic semialdehyde reductase; Provisional; Region: PRK10538 1036743006896 putative NAD(P) binding site [chemical binding]; other site 1036743006897 homodimer interface [polypeptide binding]; other site 1036743006898 homotetramer interface [polypeptide binding]; other site 1036743006899 active site 1036743006900 LytTr DNA-binding domain; Region: LytTR; smart00850 1036743006901 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1036743006902 Class II fumarases; Region: Fumarase_classII; cd01362 1036743006903 active site 1036743006904 tetramer interface [polypeptide binding]; other site 1036743006905 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1036743006906 Restriction endonuclease; Region: Mrr_cat; pfam04471 1036743006907 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1036743006908 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1036743006909 Ligand binding site; other site 1036743006910 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1036743006911 DXD motif; other site 1036743006912 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1036743006913 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1036743006914 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 1036743006915 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1036743006916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743006917 non-specific DNA binding site [nucleotide binding]; other site 1036743006918 salt bridge; other site 1036743006919 sequence-specific DNA binding site [nucleotide binding]; other site 1036743006920 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1036743006921 Catalytic site [active] 1036743006922 EamA-like transporter family; Region: EamA; pfam00892 1036743006923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743006924 dimer interface [polypeptide binding]; other site 1036743006925 putative CheW interface [polypeptide binding]; other site 1036743006926 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1036743006927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743006928 S-adenosylmethionine binding site [chemical binding]; other site 1036743006929 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; cl01566 1036743006930 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743006931 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743006932 dimer interface [polypeptide binding]; other site 1036743006933 putative CheW interface [polypeptide binding]; other site 1036743006934 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1036743006935 Transglycosylase; Region: Transgly; pfam00912 1036743006936 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1036743006937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1036743006938 AMIN domain; Region: AMIN; pfam11741 1036743006939 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1036743006940 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1036743006941 active site 1036743006942 metal binding site [ion binding]; metal-binding site 1036743006943 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1036743006944 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1036743006945 homodimer interface [polypeptide binding]; other site 1036743006946 oligonucleotide binding site [chemical binding]; other site 1036743006947 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1036743006948 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1036743006949 23S rRNA interface [nucleotide binding]; other site 1036743006950 L3 interface [polypeptide binding]; other site 1036743006951 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1036743006952 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1036743006953 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1036743006954 TolR protein; Region: tolR; TIGR02801 1036743006955 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1036743006956 enoyl-CoA hydratase; Validated; Region: PRK08139 1036743006957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743006958 substrate binding site [chemical binding]; other site 1036743006959 oxyanion hole (OAH) forming residues; other site 1036743006960 trimer interface [polypeptide binding]; other site 1036743006961 CHAP domain; Region: CHAP; cl17642 1036743006962 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1036743006963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743006964 active site 1036743006965 phosphorylation site [posttranslational modification] 1036743006966 intermolecular recognition site; other site 1036743006967 dimerization interface [polypeptide binding]; other site 1036743006968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743006969 Walker A motif; other site 1036743006970 ATP binding site [chemical binding]; other site 1036743006971 Walker B motif; other site 1036743006972 arginine finger; other site 1036743006973 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1036743006974 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1036743006975 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1036743006976 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1036743006977 polyphosphate kinase; Provisional; Region: PRK05443 1036743006978 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1036743006979 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1036743006980 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1036743006981 putative domain interface [polypeptide binding]; other site 1036743006982 putative active site [active] 1036743006983 catalytic site [active] 1036743006984 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1036743006985 putative domain interface [polypeptide binding]; other site 1036743006986 putative active site [active] 1036743006987 catalytic site [active] 1036743006988 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1036743006989 catalytic core [active] 1036743006990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1036743006991 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1036743006992 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1036743006993 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1036743006994 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1036743006995 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1036743006996 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1036743006997 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1036743006998 dimerization interface [polypeptide binding]; other site 1036743006999 putative ATP binding site [chemical binding]; other site 1036743007000 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1036743007001 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1036743007002 active site 1036743007003 substrate binding site [chemical binding]; other site 1036743007004 cosubstrate binding site; other site 1036743007005 catalytic site [active] 1036743007006 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1036743007007 active site 1036743007008 multimer interface [polypeptide binding]; other site 1036743007009 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1036743007010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743007011 Walker A/P-loop; other site 1036743007012 ATP binding site [chemical binding]; other site 1036743007013 Q-loop/lid; other site 1036743007014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743007015 ABC transporter signature motif; other site 1036743007016 Walker B; other site 1036743007017 D-loop; other site 1036743007018 ABC transporter; Region: ABC_tran_2; pfam12848 1036743007019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1036743007020 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1036743007021 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1036743007022 dimerization interface [polypeptide binding]; other site 1036743007023 ligand binding site [chemical binding]; other site 1036743007024 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1036743007025 interface (dimer of trimers) [polypeptide binding]; other site 1036743007026 Substrate-binding/catalytic site; other site 1036743007027 Zn-binding sites [ion binding]; other site 1036743007028 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1036743007029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743007030 Walker A/P-loop; other site 1036743007031 ATP binding site [chemical binding]; other site 1036743007032 Q-loop/lid; other site 1036743007033 ABC transporter signature motif; other site 1036743007034 Walker B; other site 1036743007035 D-loop; other site 1036743007036 H-loop/switch region; other site 1036743007037 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1036743007038 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1036743007039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743007040 Walker A/P-loop; other site 1036743007041 ATP binding site [chemical binding]; other site 1036743007042 Q-loop/lid; other site 1036743007043 ABC transporter signature motif; other site 1036743007044 Walker B; other site 1036743007045 D-loop; other site 1036743007046 H-loop/switch region; other site 1036743007047 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743007048 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1036743007049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007050 dimer interface [polypeptide binding]; other site 1036743007051 conserved gate region; other site 1036743007052 ABC-ATPase subunit interface; other site 1036743007053 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1036743007054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007055 dimer interface [polypeptide binding]; other site 1036743007056 conserved gate region; other site 1036743007057 putative PBP binding loops; other site 1036743007058 ABC-ATPase subunit interface; other site 1036743007059 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1036743007060 peptide binding site [polypeptide binding]; other site 1036743007061 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1036743007062 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1036743007063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1036743007064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743007065 DNA binding residues [nucleotide binding] 1036743007066 dimerization interface [polypeptide binding]; other site 1036743007067 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1036743007068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1036743007069 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1036743007070 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1036743007071 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1036743007072 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1036743007073 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1036743007074 ligand binding site [chemical binding]; other site 1036743007075 homodimer interface [polypeptide binding]; other site 1036743007076 NAD(P) binding site [chemical binding]; other site 1036743007077 trimer interface B [polypeptide binding]; other site 1036743007078 trimer interface A [polypeptide binding]; other site 1036743007079 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1036743007080 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1036743007081 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1036743007082 dimer interface [polypeptide binding]; other site 1036743007083 PYR/PP interface [polypeptide binding]; other site 1036743007084 TPP binding site [chemical binding]; other site 1036743007085 substrate binding site [chemical binding]; other site 1036743007086 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1036743007087 TPP-binding site [chemical binding]; other site 1036743007088 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1036743007089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1036743007090 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1036743007091 activation loop (A-loop); other site 1036743007092 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1036743007093 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1036743007094 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1036743007095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1036743007096 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1036743007097 acyl-activating enzyme (AAE) consensus motif; other site 1036743007098 putative AMP binding site [chemical binding]; other site 1036743007099 putative active site [active] 1036743007100 putative CoA binding site [chemical binding]; other site 1036743007101 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1036743007102 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1036743007103 active site 1036743007104 Zn binding site [ion binding]; other site 1036743007105 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1036743007106 ABC1 family; Region: ABC1; pfam03109 1036743007107 serine/threonine protein kinase; Provisional; Region: PRK14879 1036743007108 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1036743007109 putative active site [active] 1036743007110 putative catalytic site [active] 1036743007111 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1036743007112 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1036743007113 heme binding site [chemical binding]; other site 1036743007114 ferroxidase pore; other site 1036743007115 ferroxidase diiron center [ion binding]; other site 1036743007116 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1036743007117 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1036743007118 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1036743007119 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1036743007120 homodimer interaction site [polypeptide binding]; other site 1036743007121 cofactor binding site; other site 1036743007122 DNA polymerase III subunit chi; Validated; Region: PRK05728 1036743007123 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1036743007124 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743007125 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1036743007126 protein binding site [polypeptide binding]; other site 1036743007127 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1036743007128 protein binding site [polypeptide binding]; other site 1036743007129 HflC protein; Region: hflC; TIGR01932 1036743007130 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1036743007131 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1036743007132 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1036743007133 HflK protein; Region: hflK; TIGR01933 1036743007134 antiporter inner membrane protein; Provisional; Region: PRK11670 1036743007135 Domain of unknown function DUF59; Region: DUF59; pfam01883 1036743007136 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1036743007137 Walker A motif; other site 1036743007138 Stringent starvation protein B; Region: SspB; pfam04386 1036743007139 fumarate hydratase; Provisional; Region: PRK15389 1036743007140 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1036743007141 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1036743007142 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1036743007143 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1036743007144 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1036743007145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1036743007146 catalytic core [active] 1036743007147 Gram-negative porin; Region: Porin_4; pfam13609 1036743007148 Gram-negative porin; Region: Porin_4; pfam13609 1036743007149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007150 TPR motif; other site 1036743007151 TPR repeat; Region: TPR_11; pfam13414 1036743007152 binding surface 1036743007153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007154 binding surface 1036743007155 TPR motif; other site 1036743007156 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1036743007157 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1036743007158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743007159 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1036743007160 dimerization interface [polypeptide binding]; other site 1036743007161 substrate binding pocket [chemical binding]; other site 1036743007162 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1036743007163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743007164 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1036743007165 dimerization interface [polypeptide binding]; other site 1036743007166 substrate binding pocket [chemical binding]; other site 1036743007167 short chain dehydrogenase; Provisional; Region: PRK09134 1036743007168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743007169 NAD(P) binding site [chemical binding]; other site 1036743007170 active site 1036743007171 Dihydroneopterin aldolase; Region: FolB; smart00905 1036743007172 active site 1036743007173 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1036743007174 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1036743007175 GIY-YIG motif/motif A; other site 1036743007176 active site 1036743007177 catalytic site [active] 1036743007178 putative DNA binding site [nucleotide binding]; other site 1036743007179 metal binding site [ion binding]; metal-binding site 1036743007180 UvrB/uvrC motif; Region: UVR; pfam02151 1036743007181 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1036743007182 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1036743007183 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1036743007184 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1036743007185 dimer interface [polypeptide binding]; other site 1036743007186 putative functional site; other site 1036743007187 putative MPT binding site; other site 1036743007188 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1036743007189 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1036743007190 homodimer interface [polypeptide binding]; other site 1036743007191 substrate-cofactor binding pocket; other site 1036743007192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743007193 catalytic residue [active] 1036743007194 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1036743007195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743007196 putative DNA binding site [nucleotide binding]; other site 1036743007197 putative Zn2+ binding site [ion binding]; other site 1036743007198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743007199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007200 active site 1036743007201 phosphorylation site [posttranslational modification] 1036743007202 intermolecular recognition site; other site 1036743007203 dimerization interface [polypeptide binding]; other site 1036743007204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743007205 DNA binding site [nucleotide binding] 1036743007206 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1036743007207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743007208 HAMP domain; Region: HAMP; pfam00672 1036743007209 dimerization interface [polypeptide binding]; other site 1036743007210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743007211 dimer interface [polypeptide binding]; other site 1036743007212 phosphorylation site [posttranslational modification] 1036743007213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743007214 ATP binding site [chemical binding]; other site 1036743007215 Mg2+ binding site [ion binding]; other site 1036743007216 G-X-G motif; other site 1036743007217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1036743007218 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1036743007219 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1036743007220 putative binding surface; other site 1036743007221 active site 1036743007222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007223 active site 1036743007224 phosphorylation site [posttranslational modification] 1036743007225 intermolecular recognition site; other site 1036743007226 dimerization interface [polypeptide binding]; other site 1036743007227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743007228 metal binding site [ion binding]; metal-binding site 1036743007229 active site 1036743007230 I-site; other site 1036743007231 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007233 active site 1036743007234 phosphorylation site [posttranslational modification] 1036743007235 intermolecular recognition site; other site 1036743007236 dimerization interface [polypeptide binding]; other site 1036743007237 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1036743007238 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1036743007239 putative active site [active] 1036743007240 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1036743007241 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1036743007242 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 1036743007243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1036743007244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007245 active site 1036743007246 phosphorylation site [posttranslational modification] 1036743007247 intermolecular recognition site; other site 1036743007248 dimerization interface [polypeptide binding]; other site 1036743007249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743007250 DNA binding residues [nucleotide binding] 1036743007251 dimerization interface [polypeptide binding]; other site 1036743007252 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1036743007253 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007255 active site 1036743007256 phosphorylation site [posttranslational modification] 1036743007257 intermolecular recognition site; other site 1036743007258 dimerization interface [polypeptide binding]; other site 1036743007259 GAF domain; Region: GAF; pfam01590 1036743007260 Phytochrome region; Region: PHY; pfam00360 1036743007261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1036743007262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743007263 dimer interface [polypeptide binding]; other site 1036743007264 phosphorylation site [posttranslational modification] 1036743007265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743007266 ATP binding site [chemical binding]; other site 1036743007267 Mg2+ binding site [ion binding]; other site 1036743007268 G-X-G motif; other site 1036743007269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1036743007270 Ligand Binding Site [chemical binding]; other site 1036743007271 DctM-like transporters; Region: DctM; pfam06808 1036743007272 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1036743007273 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1036743007274 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1036743007275 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1036743007276 enoyl-CoA hydratase; Provisional; Region: PRK07511 1036743007277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743007278 substrate binding site [chemical binding]; other site 1036743007279 oxyanion hole (OAH) forming residues; other site 1036743007280 trimer interface [polypeptide binding]; other site 1036743007281 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1036743007282 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1036743007283 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743007284 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1036743007285 homodimer interface [polypeptide binding]; other site 1036743007286 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1036743007287 active site pocket [active] 1036743007288 glycogen synthase; Provisional; Region: glgA; PRK00654 1036743007289 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1036743007290 ADP-binding pocket [chemical binding]; other site 1036743007291 homodimer interface [polypeptide binding]; other site 1036743007292 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1036743007293 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1036743007294 ligand binding site; other site 1036743007295 oligomer interface; other site 1036743007296 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1036743007297 dimer interface [polypeptide binding]; other site 1036743007298 N-terminal domain interface [polypeptide binding]; other site 1036743007299 sulfate 1 binding site; other site 1036743007300 Restriction endonuclease; Region: Mrr_cat; pfam04471 1036743007301 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1036743007302 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1036743007303 tetramer interface [polypeptide binding]; other site 1036743007304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743007305 catalytic residue [active] 1036743007306 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1036743007307 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1036743007308 Walker A/P-loop; other site 1036743007309 ATP binding site [chemical binding]; other site 1036743007310 Q-loop/lid; other site 1036743007311 ABC transporter signature motif; other site 1036743007312 Walker B; other site 1036743007313 D-loop; other site 1036743007314 H-loop/switch region; other site 1036743007315 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1036743007316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743007317 substrate binding pocket [chemical binding]; other site 1036743007318 membrane-bound complex binding site; other site 1036743007319 hinge residues; other site 1036743007320 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1036743007321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007322 dimer interface [polypeptide binding]; other site 1036743007323 conserved gate region; other site 1036743007324 putative PBP binding loops; other site 1036743007325 ABC-ATPase subunit interface; other site 1036743007326 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1036743007327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007328 dimer interface [polypeptide binding]; other site 1036743007329 conserved gate region; other site 1036743007330 putative PBP binding loops; other site 1036743007331 ABC-ATPase subunit interface; other site 1036743007332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743007333 active site 1036743007334 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1036743007335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743007336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743007337 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1036743007338 putative effector binding pocket; other site 1036743007339 dimerization interface [polypeptide binding]; other site 1036743007340 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1036743007341 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 1036743007342 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1036743007343 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 1036743007344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1036743007345 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1036743007346 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1036743007347 oxidoreductase; Provisional; Region: PRK10015 1036743007348 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1036743007349 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1036743007350 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1036743007351 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1036743007352 Ligand binding site [chemical binding]; other site 1036743007353 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1036743007354 Nitrogen fixation protein NifW; Region: NifW; pfam03206 1036743007355 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1036743007356 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1036743007357 active site 1036743007358 catalytic residues [active] 1036743007359 metal binding site [ion binding]; metal-binding site 1036743007360 NifU-like domain; Region: NifU; pfam01106 1036743007361 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1036743007362 TspO/MBR family; Region: TspO_MBR; pfam03073 1036743007363 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1036743007364 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743007365 Walker A/P-loop; other site 1036743007366 ATP binding site [chemical binding]; other site 1036743007367 Q-loop/lid; other site 1036743007368 ABC transporter signature motif; other site 1036743007369 Walker B; other site 1036743007370 D-loop; other site 1036743007371 H-loop/switch region; other site 1036743007372 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1036743007373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743007374 Walker A/P-loop; other site 1036743007375 ATP binding site [chemical binding]; other site 1036743007376 Q-loop/lid; other site 1036743007377 ABC transporter signature motif; other site 1036743007378 Walker B; other site 1036743007379 D-loop; other site 1036743007380 H-loop/switch region; other site 1036743007381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743007382 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1036743007383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007384 dimer interface [polypeptide binding]; other site 1036743007385 conserved gate region; other site 1036743007386 putative PBP binding loops; other site 1036743007387 ABC-ATPase subunit interface; other site 1036743007388 nickel transporter permease NikB; Provisional; Region: PRK10352 1036743007389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007390 dimer interface [polypeptide binding]; other site 1036743007391 conserved gate region; other site 1036743007392 putative PBP binding loops; other site 1036743007393 ABC-ATPase subunit interface; other site 1036743007394 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743007395 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1036743007396 substrate binding site [chemical binding]; other site 1036743007397 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1036743007398 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1036743007399 NifQ; Region: NifQ; pfam04891 1036743007400 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1036743007401 probable nitrogen fixation protein; Region: TIGR02935 1036743007402 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1036743007403 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1036743007404 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1036743007405 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 1036743007406 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1036743007407 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1036743007408 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1036743007409 active site 1036743007410 NTP binding site [chemical binding]; other site 1036743007411 metal binding triad [ion binding]; metal-binding site 1036743007412 antibiotic binding site [chemical binding]; other site 1036743007413 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1036743007414 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1036743007415 Active Sites [active] 1036743007416 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1036743007417 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1036743007418 CysD dimerization site [polypeptide binding]; other site 1036743007419 G1 box; other site 1036743007420 putative GEF interaction site [polypeptide binding]; other site 1036743007421 GTP/Mg2+ binding site [chemical binding]; other site 1036743007422 Switch I region; other site 1036743007423 G2 box; other site 1036743007424 G3 box; other site 1036743007425 Switch II region; other site 1036743007426 G4 box; other site 1036743007427 G5 box; other site 1036743007428 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1036743007429 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1036743007430 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1036743007431 ligand-binding site [chemical binding]; other site 1036743007432 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743007433 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1036743007434 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1036743007435 active site 1036743007436 substrate binding site [chemical binding]; other site 1036743007437 Mg2+ binding site [ion binding]; other site 1036743007438 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1036743007439 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 1036743007440 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1036743007441 active site 1036743007442 catalytic site [active] 1036743007443 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1036743007444 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1036743007445 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1036743007446 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1036743007447 catalytic site [active] 1036743007448 active site 1036743007449 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1036743007450 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1036743007451 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1036743007452 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1036743007453 substrate binding site [chemical binding]; other site 1036743007454 dimer interface [polypeptide binding]; other site 1036743007455 ATP binding site [chemical binding]; other site 1036743007456 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1036743007457 active site 1036743007458 catalytic residues [active] 1036743007459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743007460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1036743007461 TM-ABC transporter signature motif; other site 1036743007462 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743007463 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1036743007464 TM-ABC transporter signature motif; other site 1036743007465 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1036743007466 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1036743007467 Walker A/P-loop; other site 1036743007468 ATP binding site [chemical binding]; other site 1036743007469 Q-loop/lid; other site 1036743007470 ABC transporter signature motif; other site 1036743007471 Walker B; other site 1036743007472 D-loop; other site 1036743007473 H-loop/switch region; other site 1036743007474 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1036743007475 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1036743007476 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1036743007477 ligand binding site [chemical binding]; other site 1036743007478 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1036743007479 intersubunit interface [polypeptide binding]; other site 1036743007480 active site 1036743007481 catalytic residue [active] 1036743007482 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1036743007483 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1036743007484 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1036743007485 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1036743007486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743007487 motif II; other site 1036743007488 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1036743007489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743007490 putative Zn2+ binding site [ion binding]; other site 1036743007491 putative DNA binding site [nucleotide binding]; other site 1036743007492 dimerization interface [polypeptide binding]; other site 1036743007493 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1036743007494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743007495 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1036743007496 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1036743007497 active site residue [active] 1036743007498 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1036743007499 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1036743007500 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1036743007501 Bacterial transcriptional regulator; Region: IclR; pfam01614 1036743007502 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743007503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743007504 N-terminal plug; other site 1036743007505 ligand-binding site [chemical binding]; other site 1036743007506 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1036743007507 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1036743007508 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1036743007509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743007510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743007511 non-specific DNA binding site [nucleotide binding]; other site 1036743007512 salt bridge; other site 1036743007513 sequence-specific DNA binding site [nucleotide binding]; other site 1036743007514 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1036743007515 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1036743007516 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1036743007517 pyruvate carboxylase; Reviewed; Region: PRK12999 1036743007518 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743007519 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1036743007520 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1036743007521 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1036743007522 active site 1036743007523 catalytic residues [active] 1036743007524 metal binding site [ion binding]; metal-binding site 1036743007525 homodimer binding site [polypeptide binding]; other site 1036743007526 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743007527 carboxyltransferase (CT) interaction site; other site 1036743007528 biotinylation site [posttranslational modification]; other site 1036743007529 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1036743007530 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1036743007531 methylcitrate synthase; Provisional; Region: PRK12351 1036743007532 oxalacetate binding site [chemical binding]; other site 1036743007533 citrylCoA binding site [chemical binding]; other site 1036743007534 coenzyme A binding site [chemical binding]; other site 1036743007535 catalytic triad [active] 1036743007536 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1036743007537 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1036743007538 tetramer interface [polypeptide binding]; other site 1036743007539 active site 1036743007540 Mg2+/Mn2+ binding site [ion binding]; other site 1036743007541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743007542 dimer interface [polypeptide binding]; other site 1036743007543 putative CheW interface [polypeptide binding]; other site 1036743007544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743007545 dimer interface [polypeptide binding]; other site 1036743007546 putative CheW interface [polypeptide binding]; other site 1036743007547 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1036743007548 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1036743007549 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1036743007550 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1036743007551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007552 active site 1036743007553 phosphorylation site [posttranslational modification] 1036743007554 intermolecular recognition site; other site 1036743007555 dimerization interface [polypeptide binding]; other site 1036743007556 CheB methylesterase; Region: CheB_methylest; pfam01339 1036743007557 HEAT repeats; Region: HEAT_2; pfam13646 1036743007558 HEAT repeats; Region: HEAT_2; pfam13646 1036743007559 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1036743007560 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1036743007561 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007563 active site 1036743007564 phosphorylation site [posttranslational modification] 1036743007565 intermolecular recognition site; other site 1036743007566 dimerization interface [polypeptide binding]; other site 1036743007567 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1036743007568 putative binding surface; other site 1036743007569 active site 1036743007570 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1036743007571 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1036743007572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743007573 ATP binding site [chemical binding]; other site 1036743007574 Mg2+ binding site [ion binding]; other site 1036743007575 G-X-G motif; other site 1036743007576 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1036743007577 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1036743007578 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743007579 P-loop; other site 1036743007580 Magnesium ion binding site [ion binding]; other site 1036743007581 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743007582 Magnesium ion binding site [ion binding]; other site 1036743007583 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743007584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007585 active site 1036743007586 phosphorylation site [posttranslational modification] 1036743007587 intermolecular recognition site; other site 1036743007588 dimerization interface [polypeptide binding]; other site 1036743007589 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007591 active site 1036743007592 phosphorylation site [posttranslational modification] 1036743007593 intermolecular recognition site; other site 1036743007594 dimerization interface [polypeptide binding]; other site 1036743007595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743007596 dimer interface [polypeptide binding]; other site 1036743007597 putative CheW interface [polypeptide binding]; other site 1036743007598 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 1036743007599 putative NADP binding site [chemical binding]; other site 1036743007600 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1036743007601 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1036743007602 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1036743007603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743007604 muropeptide transporter; Validated; Region: ampG; cl17669 1036743007605 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1036743007606 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743007607 N-terminal plug; other site 1036743007608 ligand-binding site [chemical binding]; other site 1036743007609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1036743007610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743007611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743007612 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743007613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743007614 Walker A/P-loop; other site 1036743007615 ATP binding site [chemical binding]; other site 1036743007616 Q-loop/lid; other site 1036743007617 ABC transporter signature motif; other site 1036743007618 Walker B; other site 1036743007619 D-loop; other site 1036743007620 H-loop/switch region; other site 1036743007621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743007622 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1036743007623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743007624 Walker A/P-loop; other site 1036743007625 ATP binding site [chemical binding]; other site 1036743007626 Q-loop/lid; other site 1036743007627 ABC transporter signature motif; other site 1036743007628 Walker B; other site 1036743007629 D-loop; other site 1036743007630 H-loop/switch region; other site 1036743007631 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1036743007632 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1036743007633 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1036743007634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743007635 FecR protein; Region: FecR; pfam04773 1036743007636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1036743007637 TPR motif; other site 1036743007638 binding surface 1036743007639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007640 binding surface 1036743007641 TPR motif; other site 1036743007642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007643 binding surface 1036743007644 TPR motif; other site 1036743007645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007646 TPR motif; other site 1036743007647 binding surface 1036743007648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007649 binding surface 1036743007650 TPR motif; other site 1036743007651 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1036743007652 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1036743007653 Probable Catalytic site; other site 1036743007654 metal-binding site 1036743007655 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1036743007656 TPR repeat; Region: TPR_11; pfam13414 1036743007657 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1036743007658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743007659 S-adenosylmethionine binding site [chemical binding]; other site 1036743007660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743007661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743007662 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1036743007663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007664 TPR motif; other site 1036743007665 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1036743007666 putative active site [active] 1036743007667 putative metal binding residues [ion binding]; other site 1036743007668 signature motif; other site 1036743007669 putative triphosphate binding site [ion binding]; other site 1036743007670 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1036743007671 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743007672 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1036743007673 peptide binding site [polypeptide binding]; other site 1036743007674 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1036743007675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007676 dimer interface [polypeptide binding]; other site 1036743007677 conserved gate region; other site 1036743007678 putative PBP binding loops; other site 1036743007679 ABC-ATPase subunit interface; other site 1036743007680 dipeptide transporter; Provisional; Region: PRK10913 1036743007681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007682 dimer interface [polypeptide binding]; other site 1036743007683 conserved gate region; other site 1036743007684 putative PBP binding loops; other site 1036743007685 ABC-ATPase subunit interface; other site 1036743007686 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1036743007687 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743007688 Walker A/P-loop; other site 1036743007689 ATP binding site [chemical binding]; other site 1036743007690 Q-loop/lid; other site 1036743007691 ABC transporter signature motif; other site 1036743007692 Walker B; other site 1036743007693 D-loop; other site 1036743007694 H-loop/switch region; other site 1036743007695 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743007696 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1036743007697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743007698 Walker A/P-loop; other site 1036743007699 ATP binding site [chemical binding]; other site 1036743007700 Q-loop/lid; other site 1036743007701 ABC transporter signature motif; other site 1036743007702 Walker B; other site 1036743007703 D-loop; other site 1036743007704 H-loop/switch region; other site 1036743007705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1036743007706 CHASE domain; Region: CHASE; pfam03924 1036743007707 PAS domain S-box; Region: sensory_box; TIGR00229 1036743007708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007709 putative active site [active] 1036743007710 heme pocket [chemical binding]; other site 1036743007711 PAS fold; Region: PAS_4; pfam08448 1036743007712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007713 putative active site [active] 1036743007714 heme pocket [chemical binding]; other site 1036743007715 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1036743007716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007717 putative active site [active] 1036743007718 heme pocket [chemical binding]; other site 1036743007719 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743007720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007721 putative active site [active] 1036743007722 heme pocket [chemical binding]; other site 1036743007723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743007724 dimer interface [polypeptide binding]; other site 1036743007725 phosphorylation site [posttranslational modification] 1036743007726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743007727 ATP binding site [chemical binding]; other site 1036743007728 Mg2+ binding site [ion binding]; other site 1036743007729 G-X-G motif; other site 1036743007730 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007732 active site 1036743007733 phosphorylation site [posttranslational modification] 1036743007734 intermolecular recognition site; other site 1036743007735 dimerization interface [polypeptide binding]; other site 1036743007736 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007738 active site 1036743007739 phosphorylation site [posttranslational modification] 1036743007740 intermolecular recognition site; other site 1036743007741 dimerization interface [polypeptide binding]; other site 1036743007742 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1036743007743 putative binding surface; other site 1036743007744 active site 1036743007745 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1036743007746 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1036743007747 putative catalytic site [active] 1036743007748 putative metal binding site [ion binding]; other site 1036743007749 putative phosphate binding site [ion binding]; other site 1036743007750 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 1036743007751 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1036743007752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1036743007753 ATP binding site [chemical binding]; other site 1036743007754 putative Mg++ binding site [ion binding]; other site 1036743007755 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1036743007756 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1036743007757 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1036743007758 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743007759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743007760 dimerization interface [polypeptide binding]; other site 1036743007761 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743007762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743007763 dimer interface [polypeptide binding]; other site 1036743007764 putative CheW interface [polypeptide binding]; other site 1036743007765 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007767 active site 1036743007768 phosphorylation site [posttranslational modification] 1036743007769 intermolecular recognition site; other site 1036743007770 dimerization interface [polypeptide binding]; other site 1036743007771 PAS domain S-box; Region: sensory_box; TIGR00229 1036743007772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007773 putative active site [active] 1036743007774 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1036743007775 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1036743007776 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1036743007777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1036743007778 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1036743007779 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1036743007780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743007781 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1036743007782 DNA binding residues [nucleotide binding] 1036743007783 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1036743007784 FecR protein; Region: FecR; pfam04773 1036743007785 Secretin and TonB N terminus short domain; Region: STN; smart00965 1036743007786 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 1036743007787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743007788 N-terminal plug; other site 1036743007789 ligand-binding site [chemical binding]; other site 1036743007790 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1036743007791 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1036743007792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007793 PAS fold; Region: PAS_3; pfam08447 1036743007794 putative active site [active] 1036743007795 heme pocket [chemical binding]; other site 1036743007796 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1036743007797 dinuclear metal binding motif [ion binding]; other site 1036743007798 cyanate transporter; Region: CynX; TIGR00896 1036743007799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743007800 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1036743007801 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1036743007802 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1036743007803 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1036743007804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743007805 Walker A/P-loop; other site 1036743007806 ATP binding site [chemical binding]; other site 1036743007807 Q-loop/lid; other site 1036743007808 ABC transporter signature motif; other site 1036743007809 Walker B; other site 1036743007810 D-loop; other site 1036743007811 H-loop/switch region; other site 1036743007812 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1036743007813 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1036743007814 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1036743007815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1036743007816 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1036743007817 ABC-ATPase subunit interface; other site 1036743007818 dimer interface [polypeptide binding]; other site 1036743007819 putative PBP binding regions; other site 1036743007820 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1036743007821 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1036743007822 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1036743007823 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1036743007824 metal binding site [ion binding]; metal-binding site 1036743007825 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1036743007826 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1036743007827 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1036743007828 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743007829 N-terminal plug; other site 1036743007830 ligand-binding site [chemical binding]; other site 1036743007831 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1036743007832 FecR protein; Region: FecR; pfam04773 1036743007833 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1036743007834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743007835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743007836 DNA binding residues [nucleotide binding] 1036743007837 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1036743007838 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1036743007839 dimer interface [polypeptide binding]; other site 1036743007840 PYR/PP interface [polypeptide binding]; other site 1036743007841 TPP binding site [chemical binding]; other site 1036743007842 substrate binding site [chemical binding]; other site 1036743007843 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1036743007844 Domain of unknown function; Region: EKR; pfam10371 1036743007845 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1036743007846 4Fe-4S binding domain; Region: Fer4; pfam00037 1036743007847 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1036743007848 TPP-binding site [chemical binding]; other site 1036743007849 dimer interface [polypeptide binding]; other site 1036743007850 OpgC protein; Region: OpgC_C; cl17858 1036743007851 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 1036743007852 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 1036743007853 dimer interface [polypeptide binding]; other site 1036743007854 active site 1036743007855 catalytic residue [active] 1036743007856 metal binding site [ion binding]; metal-binding site 1036743007857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743007858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743007859 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1036743007860 putative dimerization interface [polypeptide binding]; other site 1036743007861 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1036743007862 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1036743007863 substrate binding site [chemical binding]; other site 1036743007864 hexamer interface [polypeptide binding]; other site 1036743007865 metal binding site [ion binding]; metal-binding site 1036743007866 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1036743007867 AMP binding site [chemical binding]; other site 1036743007868 metal binding site [ion binding]; metal-binding site 1036743007869 active site 1036743007870 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1036743007871 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1036743007872 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1036743007873 TPP-binding site [chemical binding]; other site 1036743007874 dimer interface [polypeptide binding]; other site 1036743007875 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1036743007876 PYR/PP interface [polypeptide binding]; other site 1036743007877 dimer interface [polypeptide binding]; other site 1036743007878 TPP binding site [chemical binding]; other site 1036743007879 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1036743007880 PAS domain; Region: PAS; smart00091 1036743007881 PAS fold; Region: PAS_4; pfam08448 1036743007882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743007883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743007884 dimer interface [polypeptide binding]; other site 1036743007885 phosphorylation site [posttranslational modification] 1036743007886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743007887 ATP binding site [chemical binding]; other site 1036743007888 Mg2+ binding site [ion binding]; other site 1036743007889 G-X-G motif; other site 1036743007890 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743007891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743007892 active site 1036743007893 phosphorylation site [posttranslational modification] 1036743007894 intermolecular recognition site; other site 1036743007895 dimerization interface [polypeptide binding]; other site 1036743007896 PAS domain S-box; Region: sensory_box; TIGR00229 1036743007897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007898 putative active site [active] 1036743007899 heme pocket [chemical binding]; other site 1036743007900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743007901 PAS domain; Region: PAS_9; pfam13426 1036743007902 putative active site [active] 1036743007903 heme pocket [chemical binding]; other site 1036743007904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743007905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743007906 metal binding site [ion binding]; metal-binding site 1036743007907 active site 1036743007908 I-site; other site 1036743007909 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743007910 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1036743007911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743007912 Coenzyme A binding pocket [chemical binding]; other site 1036743007913 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1036743007914 DHH family; Region: DHH; pfam01368 1036743007915 DHHA1 domain; Region: DHHA1; pfam02272 1036743007916 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1036743007917 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1036743007918 putative active site [active] 1036743007919 homoserine dehydrogenase; Provisional; Region: PRK06349 1036743007920 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1036743007921 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1036743007922 aminotransferase; Validated; Region: PRK09148 1036743007923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743007924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743007925 homodimer interface [polypeptide binding]; other site 1036743007926 catalytic residue [active] 1036743007927 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743007928 ligand binding site [chemical binding]; other site 1036743007929 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1036743007930 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1036743007931 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1036743007932 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1036743007933 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1036743007934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743007935 dimer interface [polypeptide binding]; other site 1036743007936 conserved gate region; other site 1036743007937 ABC-ATPase subunit interface; other site 1036743007938 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1036743007939 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1036743007940 Walker A/P-loop; other site 1036743007941 ATP binding site [chemical binding]; other site 1036743007942 Q-loop/lid; other site 1036743007943 ABC transporter signature motif; other site 1036743007944 Walker B; other site 1036743007945 D-loop; other site 1036743007946 H-loop/switch region; other site 1036743007947 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1036743007948 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1036743007949 trimer interface [polypeptide binding]; other site 1036743007950 putative metal binding site [ion binding]; other site 1036743007951 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1036743007952 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1036743007953 aspartate aminotransferase; Provisional; Region: PRK05764 1036743007954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743007955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743007956 homodimer interface [polypeptide binding]; other site 1036743007957 catalytic residue [active] 1036743007958 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1036743007959 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1036743007960 Peptidase family M48; Region: Peptidase_M48; cl12018 1036743007961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743007962 TPR motif; other site 1036743007963 binding surface 1036743007964 LrgA family; Region: LrgA; pfam03788 1036743007965 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1036743007966 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1036743007967 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1036743007968 catalytic residues [active] 1036743007969 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1036743007970 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1036743007971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743007972 non-specific DNA binding site [nucleotide binding]; other site 1036743007973 salt bridge; other site 1036743007974 sequence-specific DNA binding site [nucleotide binding]; other site 1036743007975 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1036743007976 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1036743007977 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1036743007978 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 1036743007979 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1036743007980 thiS-thiF/thiG interaction site; other site 1036743007981 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1036743007982 ThiS interaction site; other site 1036743007983 putative active site [active] 1036743007984 tetramer interface [polypeptide binding]; other site 1036743007985 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1036743007986 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1036743007987 active site 1036743007988 trimer interface [polypeptide binding]; other site 1036743007989 dimer interface [polypeptide binding]; other site 1036743007990 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1036743007991 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1036743007992 carboxyltransferase (CT) interaction site; other site 1036743007993 biotinylation site [posttranslational modification]; other site 1036743007994 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1036743007995 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743007996 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1036743007997 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1036743007998 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1036743007999 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 1036743008000 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1036743008001 mce related protein; Region: MCE; pfam02470 1036743008002 mce related protein; Region: MCE; pfam02470 1036743008003 NADH dehydrogenase; Validated; Region: PRK08183 1036743008004 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1036743008005 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1036743008006 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1036743008007 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1036743008008 active site 1036743008009 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1036743008010 TSCPD domain; Region: TSCPD; pfam12637 1036743008011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743008012 non-specific DNA binding site [nucleotide binding]; other site 1036743008013 salt bridge; other site 1036743008014 sequence-specific DNA binding site [nucleotide binding]; other site 1036743008015 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1036743008016 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1036743008017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743008018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743008019 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1036743008020 Permease; Region: Permease; pfam02405 1036743008021 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1036743008022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743008023 Walker A/P-loop; other site 1036743008024 ATP binding site [chemical binding]; other site 1036743008025 Q-loop/lid; other site 1036743008026 ABC transporter signature motif; other site 1036743008027 Walker B; other site 1036743008028 D-loop; other site 1036743008029 H-loop/switch region; other site 1036743008030 mce related protein; Region: MCE; pfam02470 1036743008031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1036743008032 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1036743008033 Peptidase family M48; Region: Peptidase_M48; pfam01435 1036743008034 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008036 metal binding site [ion binding]; metal-binding site 1036743008037 active site 1036743008038 I-site; other site 1036743008039 WYL domain; Region: WYL; pfam13280 1036743008040 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1036743008041 transmembrane helices; other site 1036743008042 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1036743008043 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1036743008044 ligand binding site [chemical binding]; other site 1036743008045 NAD binding site [chemical binding]; other site 1036743008046 tetramer interface [polypeptide binding]; other site 1036743008047 catalytic site [active] 1036743008048 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1036743008049 L-serine binding site [chemical binding]; other site 1036743008050 ACT domain interface; other site 1036743008051 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1036743008052 homotrimer interaction site [polypeptide binding]; other site 1036743008053 putative active site [active] 1036743008054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1036743008055 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1036743008056 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1036743008057 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1036743008058 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743008059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743008060 dimer interface [polypeptide binding]; other site 1036743008061 putative CheW interface [polypeptide binding]; other site 1036743008062 CHAP domain; Region: CHAP; cl17642 1036743008063 carboxylate-amine ligase; Provisional; Region: PRK13515 1036743008064 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1036743008065 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1036743008066 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1036743008067 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1036743008068 MOFRL family; Region: MOFRL; pfam05161 1036743008069 pyruvate kinase; Provisional; Region: PRK06247 1036743008070 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1036743008071 domain interfaces; other site 1036743008072 active site 1036743008073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1036743008074 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1036743008075 dimer interface [polypeptide binding]; other site 1036743008076 active site 1036743008077 metal binding site [ion binding]; metal-binding site 1036743008078 glutathione binding site [chemical binding]; other site 1036743008079 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1036743008080 FeoA domain; Region: FeoA; pfam04023 1036743008081 FeoA domain; Region: FeoA; pfam04023 1036743008082 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1036743008083 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1036743008084 G1 box; other site 1036743008085 GTP/Mg2+ binding site [chemical binding]; other site 1036743008086 Switch I region; other site 1036743008087 G2 box; other site 1036743008088 G3 box; other site 1036743008089 Switch II region; other site 1036743008090 G4 box; other site 1036743008091 G5 box; other site 1036743008092 Nucleoside recognition; Region: Gate; pfam07670 1036743008093 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1036743008094 FeoC like transcriptional regulator; Region: FeoC; pfam09012 1036743008095 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1036743008096 PAS domain; Region: PAS; smart00091 1036743008097 PAS fold; Region: PAS_7; pfam12860 1036743008098 putative active site [active] 1036743008099 heme pocket [chemical binding]; other site 1036743008100 PAS fold; Region: PAS_7; pfam12860 1036743008101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743008102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743008103 dimer interface [polypeptide binding]; other site 1036743008104 phosphorylation site [posttranslational modification] 1036743008105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743008106 ATP binding site [chemical binding]; other site 1036743008107 Mg2+ binding site [ion binding]; other site 1036743008108 G-X-G motif; other site 1036743008109 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1036743008110 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1036743008111 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1036743008112 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1036743008113 Walker A/P-loop; other site 1036743008114 ATP binding site [chemical binding]; other site 1036743008115 Q-loop/lid; other site 1036743008116 ABC transporter signature motif; other site 1036743008117 Walker B; other site 1036743008118 D-loop; other site 1036743008119 H-loop/switch region; other site 1036743008120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1036743008121 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1036743008122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743008123 dimer interface [polypeptide binding]; other site 1036743008124 conserved gate region; other site 1036743008125 putative PBP binding loops; other site 1036743008126 ABC-ATPase subunit interface; other site 1036743008127 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1036743008128 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1036743008129 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1036743008130 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1036743008131 Walker A; other site 1036743008132 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1036743008133 G4 box; other site 1036743008134 G5 box; other site 1036743008135 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1036743008136 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1036743008137 active site 1036743008138 substrate binding site [chemical binding]; other site 1036743008139 coenzyme B12 binding site [chemical binding]; other site 1036743008140 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1036743008141 B12 binding site [chemical binding]; other site 1036743008142 cobalt ligand [ion binding]; other site 1036743008143 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1036743008144 heterodimer interface [polypeptide binding]; other site 1036743008145 substrate interaction site [chemical binding]; other site 1036743008146 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1036743008147 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1036743008148 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1036743008149 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1036743008150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1036743008151 active site 1036743008152 metal binding site [ion binding]; metal-binding site 1036743008153 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1036743008154 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743008155 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743008156 dimer interface [polypeptide binding]; other site 1036743008157 putative CheW interface [polypeptide binding]; other site 1036743008158 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1036743008159 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1036743008160 active site 1036743008161 homotetramer interface [polypeptide binding]; other site 1036743008162 Glucokinase; Region: Glucokinase; cl17310 1036743008163 glucokinase, proteobacterial type; Region: glk; TIGR00749 1036743008164 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 1036743008165 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1036743008166 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1036743008167 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1036743008168 tetramer interface [polypeptide binding]; other site 1036743008169 heme binding pocket [chemical binding]; other site 1036743008170 NADPH binding site [chemical binding]; other site 1036743008171 Cupin domain; Region: Cupin_2; cl17218 1036743008172 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1036743008173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743008174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743008175 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1036743008176 putative ADP-binding pocket [chemical binding]; other site 1036743008177 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1036743008178 putative ADP-binding pocket [chemical binding]; other site 1036743008179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743008180 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1036743008181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1036743008182 active site 1036743008183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1036743008184 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1036743008185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1036743008186 active site 1036743008187 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1036743008188 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1036743008189 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1036743008190 G1 box; other site 1036743008191 putative GEF interaction site [polypeptide binding]; other site 1036743008192 GTP/Mg2+ binding site [chemical binding]; other site 1036743008193 Switch I region; other site 1036743008194 G2 box; other site 1036743008195 G3 box; other site 1036743008196 Switch II region; other site 1036743008197 G4 box; other site 1036743008198 G5 box; other site 1036743008199 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1036743008200 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1036743008201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743008202 Walker A/P-loop; other site 1036743008203 ATP binding site [chemical binding]; other site 1036743008204 Q-loop/lid; other site 1036743008205 ABC transporter signature motif; other site 1036743008206 Walker B; other site 1036743008207 D-loop; other site 1036743008208 H-loop/switch region; other site 1036743008209 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1036743008210 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1036743008211 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1036743008212 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1036743008213 CPxP motif; other site 1036743008214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1036743008215 active site residue [active] 1036743008216 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1036743008217 Ligand Binding Site [chemical binding]; other site 1036743008218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1036743008219 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1036743008220 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1036743008221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743008222 FeS/SAM binding site; other site 1036743008223 HemN C-terminal domain; Region: HemN_C; pfam06969 1036743008224 Hemerythrin; Region: Hemerythrin; cd12107 1036743008225 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743008226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743008227 active site 1036743008228 phosphorylation site [posttranslational modification] 1036743008229 intermolecular recognition site; other site 1036743008230 dimerization interface [polypeptide binding]; other site 1036743008231 enoyl-CoA hydratase; Provisional; Region: PRK06127 1036743008232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743008233 substrate binding site [chemical binding]; other site 1036743008234 oxyanion hole (OAH) forming residues; other site 1036743008235 trimer interface [polypeptide binding]; other site 1036743008236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743008237 active site 1036743008238 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1036743008239 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1036743008240 substrate-cofactor binding pocket; other site 1036743008241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743008242 catalytic residue [active] 1036743008243 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1036743008244 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1036743008245 putative active site; other site 1036743008246 catalytic residue [active] 1036743008247 NMT1/THI5 like; Region: NMT1; pfam09084 1036743008248 PAS domain; Region: PAS_9; pfam13426 1036743008249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008250 metal binding site [ion binding]; metal-binding site 1036743008251 active site 1036743008252 I-site; other site 1036743008253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1036743008254 classical (c) SDRs; Region: SDR_c; cd05233 1036743008255 NAD(P) binding site [chemical binding]; other site 1036743008256 active site 1036743008257 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 1036743008258 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1036743008259 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1036743008260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1036743008261 Peptidase M15; Region: Peptidase_M15_3; cl01194 1036743008262 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1036743008263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1036743008264 substrate binding pocket [chemical binding]; other site 1036743008265 membrane-bound complex binding site; other site 1036743008266 hinge residues; other site 1036743008267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743008268 dimer interface [polypeptide binding]; other site 1036743008269 phosphorylation site [posttranslational modification] 1036743008270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743008271 ATP binding site [chemical binding]; other site 1036743008272 Mg2+ binding site [ion binding]; other site 1036743008273 G-X-G motif; other site 1036743008274 acyl-CoA synthetase; Validated; Region: PRK07638 1036743008275 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1036743008276 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1036743008277 acyl-activating enzyme (AAE) consensus motif; other site 1036743008278 acyl-activating enzyme (AAE) consensus motif; other site 1036743008279 AMP binding site [chemical binding]; other site 1036743008280 active site 1036743008281 CoA binding site [chemical binding]; other site 1036743008282 MarC family integral membrane protein; Region: MarC; pfam01914 1036743008283 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1036743008284 Transglycosylase; Region: Transgly; pfam00912 1036743008285 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1036743008286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1036743008287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743008288 Walker A motif; other site 1036743008289 ATP binding site [chemical binding]; other site 1036743008290 Walker B motif; other site 1036743008291 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1036743008292 AAA domain; Region: AAA_12; pfam13087 1036743008293 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1036743008294 additional DNA contacts [nucleotide binding]; other site 1036743008295 mismatch recognition site; other site 1036743008296 active site 1036743008297 zinc binding site [ion binding]; other site 1036743008298 DNA intercalation site [nucleotide binding]; other site 1036743008299 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1036743008300 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1036743008301 NAD binding site [chemical binding]; other site 1036743008302 substrate binding site [chemical binding]; other site 1036743008303 putative active site [active] 1036743008304 Predicted transcriptional regulators [Transcription]; Region: COG1733 1036743008305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743008306 dimerization interface [polypeptide binding]; other site 1036743008307 putative DNA binding site [nucleotide binding]; other site 1036743008308 putative Zn2+ binding site [ion binding]; other site 1036743008309 putative protease; Provisional; Region: PRK15447 1036743008310 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1036743008311 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1036743008312 Peptidase family U32; Region: Peptidase_U32; pfam01136 1036743008313 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1036743008314 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 1036743008315 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1036743008316 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1036743008317 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1036743008318 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1036743008319 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1036743008320 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1036743008321 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1036743008322 flagellin; Reviewed; Region: PRK08869 1036743008323 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1036743008324 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1036743008325 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1036743008326 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1036743008327 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1036743008328 Flagellar protein FliS; Region: FliS; cl00654 1036743008329 RNA polymerase sigma factor; Reviewed; Region: PRK05602 1036743008330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743008331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743008332 DNA binding residues [nucleotide binding] 1036743008333 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1036743008334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743008335 putative substrate translocation pore; other site 1036743008336 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1036743008337 circadian clock protein KaiC; Reviewed; Region: PRK09302 1036743008338 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743008339 Walker A motif; other site 1036743008340 ATP binding site [chemical binding]; other site 1036743008341 Walker B motif; other site 1036743008342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743008343 Walker A motif; other site 1036743008344 Walker A motif; other site 1036743008345 ATP binding site [chemical binding]; other site 1036743008346 Walker B motif; other site 1036743008347 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1036743008348 tetramer interface [polypeptide binding]; other site 1036743008349 dimer interface [polypeptide binding]; other site 1036743008350 PAS fold; Region: PAS_4; pfam08448 1036743008351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743008352 putative active site [active] 1036743008353 heme pocket [chemical binding]; other site 1036743008354 PAS domain; Region: PAS_9; pfam13426 1036743008355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1036743008356 HWE histidine kinase; Region: HWE_HK; smart00911 1036743008357 Predicted membrane protein [Function unknown]; Region: COG1238 1036743008358 Cache domain; Region: Cache_1; pfam02743 1036743008359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743008360 dimerization interface [polypeptide binding]; other site 1036743008361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743008362 dimer interface [polypeptide binding]; other site 1036743008363 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743008364 putative CheW interface [polypeptide binding]; other site 1036743008365 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1036743008366 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1036743008367 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1036743008368 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1036743008369 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1036743008370 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1036743008371 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1036743008372 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1036743008373 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1036743008374 putative active site [active] 1036743008375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743008376 S-adenosylmethionine binding site [chemical binding]; other site 1036743008377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743008378 dimerization interface [polypeptide binding]; other site 1036743008379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743008380 dimer interface [polypeptide binding]; other site 1036743008381 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1036743008382 putative CheW interface [polypeptide binding]; other site 1036743008383 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008385 metal binding site [ion binding]; metal-binding site 1036743008386 active site 1036743008387 I-site; other site 1036743008388 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1036743008389 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1036743008390 active site 1036743008391 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1036743008392 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1036743008393 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1036743008394 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1036743008395 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1036743008396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1036743008397 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1036743008398 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1036743008399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1036743008400 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1036743008401 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1036743008402 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1036743008403 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1036743008404 putative CheA interaction surface; other site 1036743008405 MULE transposase domain; Region: MULE; pfam10551 1036743008406 potential frameshift: common BLAST hit: gi|83582744|ref|YP_425050.1| transposase 1036743008407 EcsC protein family; Region: EcsC; pfam12787 1036743008408 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008409 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008410 metal binding site [ion binding]; metal-binding site 1036743008411 active site 1036743008412 I-site; other site 1036743008413 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1036743008414 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1036743008415 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1036743008416 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1036743008417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743008418 catalytic residue [active] 1036743008419 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1036743008420 FeS assembly protein SufD; Region: sufD; TIGR01981 1036743008421 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1036743008422 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1036743008423 Walker A/P-loop; other site 1036743008424 ATP binding site [chemical binding]; other site 1036743008425 Q-loop/lid; other site 1036743008426 ABC transporter signature motif; other site 1036743008427 Walker B; other site 1036743008428 D-loop; other site 1036743008429 H-loop/switch region; other site 1036743008430 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1036743008431 putative ABC transporter; Region: ycf24; CHL00085 1036743008432 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1036743008433 Transcriptional regulator; Region: Rrf2; pfam02082 1036743008434 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1036743008435 glycogen branching enzyme; Provisional; Region: PRK05402 1036743008436 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1036743008437 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1036743008438 active site 1036743008439 catalytic site [active] 1036743008440 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1036743008441 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1036743008442 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1036743008443 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1036743008444 active site 1036743008445 catalytic site [active] 1036743008446 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1036743008447 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1036743008448 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1036743008449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743008450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008452 metal binding site [ion binding]; metal-binding site 1036743008453 active site 1036743008454 I-site; other site 1036743008455 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1036743008456 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1036743008457 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008459 metal binding site [ion binding]; metal-binding site 1036743008460 active site 1036743008461 I-site; other site 1036743008462 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1036743008463 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1036743008464 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1036743008465 Iron permease FTR1 family; Region: FTR1; cl00475 1036743008466 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1036743008467 Imelysin; Region: Peptidase_M75; pfam09375 1036743008468 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1036743008469 Imelysin; Region: Peptidase_M75; pfam09375 1036743008470 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1036743008471 CHASE4 domain; Region: CHASE4; pfam05228 1036743008472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743008473 dimerization interface [polypeptide binding]; other site 1036743008474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008476 metal binding site [ion binding]; metal-binding site 1036743008477 active site 1036743008478 I-site; other site 1036743008479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743008480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1036743008481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743008482 active site 1036743008483 phosphorylation site [posttranslational modification] 1036743008484 intermolecular recognition site; other site 1036743008485 dimerization interface [polypeptide binding]; other site 1036743008486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743008487 DNA binding residues [nucleotide binding] 1036743008488 dimerization interface [polypeptide binding]; other site 1036743008489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008491 metal binding site [ion binding]; metal-binding site 1036743008492 active site 1036743008493 I-site; other site 1036743008494 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743008495 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1036743008496 dimer interface [polypeptide binding]; other site 1036743008497 active site 1036743008498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743008499 dimer interface [polypeptide binding]; other site 1036743008500 phosphorylation site [posttranslational modification] 1036743008501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743008502 ATP binding site [chemical binding]; other site 1036743008503 Mg2+ binding site [ion binding]; other site 1036743008504 G-X-G motif; other site 1036743008505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1036743008506 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1036743008507 Ligand Binding Site [chemical binding]; other site 1036743008508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1036743008509 Predicted kinase [General function prediction only]; Region: COG0645 1036743008510 AAA domain; Region: AAA_17; pfam13207 1036743008511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743008512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743008513 sequence-specific DNA binding site [nucleotide binding]; other site 1036743008514 salt bridge; other site 1036743008515 Cupin domain; Region: Cupin_2; pfam07883 1036743008516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743008517 dimerization interface [polypeptide binding]; other site 1036743008518 putative DNA binding site [nucleotide binding]; other site 1036743008519 putative Zn2+ binding site [ion binding]; other site 1036743008520 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1036743008521 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1036743008522 putative active site [active] 1036743008523 Zn binding site [ion binding]; other site 1036743008524 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1036743008525 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1036743008526 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1036743008527 substrate binding pocket [chemical binding]; other site 1036743008528 chain length determination region; other site 1036743008529 substrate-Mg2+ binding site; other site 1036743008530 catalytic residues [active] 1036743008531 aspartate-rich region 1; other site 1036743008532 active site lid residues [active] 1036743008533 aspartate-rich region 2; other site 1036743008534 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 1036743008535 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1036743008536 TPP-binding site; other site 1036743008537 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1036743008538 PYR/PP interface [polypeptide binding]; other site 1036743008539 dimer interface [polypeptide binding]; other site 1036743008540 TPP binding site [chemical binding]; other site 1036743008541 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1036743008542 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1036743008543 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1036743008544 RNA binding surface [nucleotide binding]; other site 1036743008545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743008546 S-adenosylmethionine binding site [chemical binding]; other site 1036743008547 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1036743008548 tandem repeat interface [polypeptide binding]; other site 1036743008549 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1036743008550 oligomer interface [polypeptide binding]; other site 1036743008551 active site residues [active] 1036743008552 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1036743008553 tandem repeat interface [polypeptide binding]; other site 1036743008554 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1036743008555 oligomer interface [polypeptide binding]; other site 1036743008556 active site residues [active] 1036743008557 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1036743008558 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1036743008559 Tetramer interface [polypeptide binding]; other site 1036743008560 active site 1036743008561 FMN-binding site [chemical binding]; other site 1036743008562 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1036743008563 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1036743008564 NAD binding site [chemical binding]; other site 1036743008565 homotetramer interface [polypeptide binding]; other site 1036743008566 homodimer interface [polypeptide binding]; other site 1036743008567 substrate binding site [chemical binding]; other site 1036743008568 active site 1036743008569 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1036743008570 chaperone protein DnaJ; Provisional; Region: PRK14299 1036743008571 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1036743008572 HSP70 interaction site [polypeptide binding]; other site 1036743008573 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1036743008574 substrate binding site [polypeptide binding]; other site 1036743008575 dimer interface [polypeptide binding]; other site 1036743008576 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1036743008577 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1036743008578 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1036743008579 Cation efflux family; Region: Cation_efflux; cl00316 1036743008580 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1036743008581 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1036743008582 fructokinase; Reviewed; Region: PRK09557 1036743008583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1036743008584 nucleotide binding site [chemical binding]; other site 1036743008585 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1036743008586 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1036743008587 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1036743008588 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1036743008589 Walker A/P-loop; other site 1036743008590 ATP binding site [chemical binding]; other site 1036743008591 Q-loop/lid; other site 1036743008592 ABC transporter signature motif; other site 1036743008593 Walker B; other site 1036743008594 D-loop; other site 1036743008595 H-loop/switch region; other site 1036743008596 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1036743008597 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743008598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743008599 ligand binding site [chemical binding]; other site 1036743008600 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1036743008601 putative switch regulator; other site 1036743008602 non-specific DNA interactions [nucleotide binding]; other site 1036743008603 DNA binding site [nucleotide binding] 1036743008604 sequence specific DNA binding site [nucleotide binding]; other site 1036743008605 putative cAMP binding site [chemical binding]; other site 1036743008606 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 1036743008607 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743008608 ligand binding site [chemical binding]; other site 1036743008609 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1036743008610 putative switch regulator; other site 1036743008611 non-specific DNA interactions [nucleotide binding]; other site 1036743008612 DNA binding site [nucleotide binding] 1036743008613 sequence specific DNA binding site [nucleotide binding]; other site 1036743008614 putative cAMP binding site [chemical binding]; other site 1036743008615 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1036743008616 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1036743008617 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1036743008618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743008619 binding surface 1036743008620 TPR motif; other site 1036743008621 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743008622 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1036743008623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1036743008624 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1036743008625 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 1036743008626 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1036743008627 putative active site [active] 1036743008628 catalytic site [active] 1036743008629 putative metal binding site [ion binding]; other site 1036743008630 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1036743008631 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1036743008632 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1036743008633 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1036743008634 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1036743008635 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1036743008636 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1036743008637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743008638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743008639 homodimer interface [polypeptide binding]; other site 1036743008640 catalytic residue [active] 1036743008641 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1036743008642 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 1036743008643 intracellular septation protein A; Reviewed; Region: PRK00259 1036743008644 ATP12 chaperone protein; Region: ATP12; cl02228 1036743008645 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1036743008646 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1036743008647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743008648 motif II; other site 1036743008649 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1036743008650 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1036743008651 RNA binding surface [nucleotide binding]; other site 1036743008652 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1036743008653 active site 1036743008654 recombination factor protein RarA; Reviewed; Region: PRK13342 1036743008655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743008656 Walker A motif; other site 1036743008657 ATP binding site [chemical binding]; other site 1036743008658 Walker B motif; other site 1036743008659 arginine finger; other site 1036743008660 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1036743008661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743008662 dimerization interface [polypeptide binding]; other site 1036743008663 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743008664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743008665 metal binding site [ion binding]; metal-binding site 1036743008666 active site 1036743008667 I-site; other site 1036743008668 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1036743008669 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743008670 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1036743008671 protein binding site [polypeptide binding]; other site 1036743008672 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1036743008673 protein binding site [polypeptide binding]; other site 1036743008674 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1036743008675 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1036743008676 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1036743008677 alphaNTD - beta interaction site [polypeptide binding]; other site 1036743008678 alphaNTD homodimer interface [polypeptide binding]; other site 1036743008679 alphaNTD - beta' interaction site [polypeptide binding]; other site 1036743008680 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1036743008681 30S ribosomal protein S11; Validated; Region: PRK05309 1036743008682 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1036743008683 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1036743008684 adenylate kinase; Reviewed; Region: adk; PRK00279 1036743008685 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1036743008686 AMP-binding site [chemical binding]; other site 1036743008687 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1036743008688 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1036743008689 SecY translocase; Region: SecY; pfam00344 1036743008690 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1036743008691 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1036743008692 23S rRNA binding site [nucleotide binding]; other site 1036743008693 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1036743008694 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1036743008695 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1036743008696 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1036743008697 5S rRNA interface [nucleotide binding]; other site 1036743008698 L27 interface [polypeptide binding]; other site 1036743008699 23S rRNA interface [nucleotide binding]; other site 1036743008700 L5 interface [polypeptide binding]; other site 1036743008701 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1036743008702 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1036743008703 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1036743008704 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1036743008705 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1036743008706 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1036743008707 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1036743008708 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1036743008709 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1036743008710 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1036743008711 RNA binding site [nucleotide binding]; other site 1036743008712 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1036743008713 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1036743008714 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1036743008715 23S rRNA interface [nucleotide binding]; other site 1036743008716 putative translocon interaction site; other site 1036743008717 signal recognition particle (SRP54) interaction site; other site 1036743008718 L23 interface [polypeptide binding]; other site 1036743008719 trigger factor interaction site; other site 1036743008720 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1036743008721 23S rRNA interface [nucleotide binding]; other site 1036743008722 5S rRNA interface [nucleotide binding]; other site 1036743008723 putative antibiotic binding site [chemical binding]; other site 1036743008724 L25 interface [polypeptide binding]; other site 1036743008725 L27 interface [polypeptide binding]; other site 1036743008726 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1036743008727 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1036743008728 G-X-X-G motif; other site 1036743008729 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1036743008730 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1036743008731 putative translocon binding site; other site 1036743008732 protein-rRNA interface [nucleotide binding]; other site 1036743008733 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1036743008734 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1036743008735 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1036743008736 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1036743008737 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1036743008738 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1036743008739 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1036743008740 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1036743008741 elongation factor Tu; Reviewed; Region: PRK00049 1036743008742 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1036743008743 G1 box; other site 1036743008744 GEF interaction site [polypeptide binding]; other site 1036743008745 GTP/Mg2+ binding site [chemical binding]; other site 1036743008746 Switch I region; other site 1036743008747 G2 box; other site 1036743008748 G3 box; other site 1036743008749 Switch II region; other site 1036743008750 G4 box; other site 1036743008751 G5 box; other site 1036743008752 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1036743008753 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1036743008754 Antibiotic Binding Site [chemical binding]; other site 1036743008755 elongation factor G; Reviewed; Region: PRK00007 1036743008756 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1036743008757 G1 box; other site 1036743008758 putative GEF interaction site [polypeptide binding]; other site 1036743008759 GTP/Mg2+ binding site [chemical binding]; other site 1036743008760 Switch I region; other site 1036743008761 G2 box; other site 1036743008762 G3 box; other site 1036743008763 Switch II region; other site 1036743008764 G4 box; other site 1036743008765 G5 box; other site 1036743008766 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1036743008767 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1036743008768 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1036743008769 30S ribosomal protein S7; Validated; Region: PRK05302 1036743008770 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1036743008771 S17 interaction site [polypeptide binding]; other site 1036743008772 S8 interaction site; other site 1036743008773 16S rRNA interaction site [nucleotide binding]; other site 1036743008774 streptomycin interaction site [chemical binding]; other site 1036743008775 23S rRNA interaction site [nucleotide binding]; other site 1036743008776 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1036743008777 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1036743008778 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1036743008779 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1036743008780 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1036743008781 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1036743008782 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1036743008783 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1036743008784 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1036743008785 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1036743008786 DNA binding site [nucleotide binding] 1036743008787 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1036743008788 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1036743008789 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1036743008790 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1036743008791 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1036743008792 RPB11 interaction site [polypeptide binding]; other site 1036743008793 RPB12 interaction site [polypeptide binding]; other site 1036743008794 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1036743008795 RPB3 interaction site [polypeptide binding]; other site 1036743008796 RPB1 interaction site [polypeptide binding]; other site 1036743008797 RPB11 interaction site [polypeptide binding]; other site 1036743008798 RPB10 interaction site [polypeptide binding]; other site 1036743008799 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1036743008800 L11 interface [polypeptide binding]; other site 1036743008801 putative EF-Tu interaction site [polypeptide binding]; other site 1036743008802 putative EF-G interaction site [polypeptide binding]; other site 1036743008803 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1036743008804 23S rRNA interface [nucleotide binding]; other site 1036743008805 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1036743008806 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1036743008807 mRNA/rRNA interface [nucleotide binding]; other site 1036743008808 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1036743008809 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1036743008810 23S rRNA interface [nucleotide binding]; other site 1036743008811 L7/L12 interface [polypeptide binding]; other site 1036743008812 putative thiostrepton binding site; other site 1036743008813 L25 interface [polypeptide binding]; other site 1036743008814 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1036743008815 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1036743008816 putative homodimer interface [polypeptide binding]; other site 1036743008817 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1036743008818 heterodimer interface [polypeptide binding]; other site 1036743008819 homodimer interface [polypeptide binding]; other site 1036743008820 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1036743008821 elongation factor Tu; Reviewed; Region: PRK00049 1036743008822 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1036743008823 G1 box; other site 1036743008824 GEF interaction site [polypeptide binding]; other site 1036743008825 GTP/Mg2+ binding site [chemical binding]; other site 1036743008826 Switch I region; other site 1036743008827 G2 box; other site 1036743008828 G3 box; other site 1036743008829 Switch II region; other site 1036743008830 G4 box; other site 1036743008831 G5 box; other site 1036743008832 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1036743008833 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1036743008834 Antibiotic Binding Site [chemical binding]; other site 1036743008835 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1036743008836 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1036743008837 acyl-CoA esterase; Provisional; Region: PRK10673 1036743008838 PGAP1-like protein; Region: PGAP1; pfam07819 1036743008839 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1036743008840 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1036743008841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743008842 ATP binding site [chemical binding]; other site 1036743008843 Mg2+ binding site [ion binding]; other site 1036743008844 G-X-G motif; other site 1036743008845 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1036743008846 anchoring element; other site 1036743008847 dimer interface [polypeptide binding]; other site 1036743008848 ATP binding site [chemical binding]; other site 1036743008849 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1036743008850 active site 1036743008851 metal binding site [ion binding]; metal-binding site 1036743008852 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1036743008853 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1036743008854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743008855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743008856 Restriction endonuclease; Region: Mrr_cat; pfam04471 1036743008857 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1036743008858 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1036743008859 Isochorismatase family; Region: Isochorismatase; pfam00857 1036743008860 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1036743008861 catalytic triad [active] 1036743008862 dimer interface [polypeptide binding]; other site 1036743008863 conserved cis-peptide bond; other site 1036743008864 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1036743008865 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1036743008866 ATP binding site [chemical binding]; other site 1036743008867 Mg++ binding site [ion binding]; other site 1036743008868 motif III; other site 1036743008869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1036743008870 nucleotide binding region [chemical binding]; other site 1036743008871 ATP-binding site [chemical binding]; other site 1036743008872 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 1036743008873 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1036743008874 dimer interface [polypeptide binding]; other site 1036743008875 PYR/PP interface [polypeptide binding]; other site 1036743008876 TPP binding site [chemical binding]; other site 1036743008877 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1036743008878 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1036743008879 TPP-binding site [chemical binding]; other site 1036743008880 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1036743008881 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1036743008882 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1036743008883 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1036743008884 dimer interface [polypeptide binding]; other site 1036743008885 PYR/PP interface [polypeptide binding]; other site 1036743008886 TPP binding site [chemical binding]; other site 1036743008887 substrate binding site [chemical binding]; other site 1036743008888 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1036743008889 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1036743008890 TPP-binding site [chemical binding]; other site 1036743008891 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1036743008892 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1036743008893 diiron binding motif [ion binding]; other site 1036743008894 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1036743008895 putative hydrolase; Provisional; Region: PRK11460 1036743008896 PAS domain; Region: PAS_9; pfam13426 1036743008897 PAS fold; Region: PAS_7; pfam12860 1036743008898 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1036743008899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743008900 dimer interface [polypeptide binding]; other site 1036743008901 phosphorylation site [posttranslational modification] 1036743008902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743008903 ATP binding site [chemical binding]; other site 1036743008904 Mg2+ binding site [ion binding]; other site 1036743008905 G-X-G motif; other site 1036743008906 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743008907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743008908 active site 1036743008909 phosphorylation site [posttranslational modification] 1036743008910 intermolecular recognition site; other site 1036743008911 dimerization interface [polypeptide binding]; other site 1036743008912 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743008914 active site 1036743008915 phosphorylation site [posttranslational modification] 1036743008916 intermolecular recognition site; other site 1036743008917 dimerization interface [polypeptide binding]; other site 1036743008918 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1036743008919 NnrU protein; Region: NnrU; cl17713 1036743008920 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1036743008921 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1036743008922 Domain of unknown function DUF87; Region: DUF87; pfam01935 1036743008923 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1036743008924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1036743008925 active site 1036743008926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743008927 NAD(P) binding site [chemical binding]; other site 1036743008928 active site 1036743008929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743008930 S-adenosylmethionine binding site [chemical binding]; other site 1036743008931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1036743008932 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1036743008933 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743008934 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1036743008935 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1036743008936 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1036743008937 active site 1036743008938 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743008939 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1036743008940 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743008941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743008942 S-adenosylmethionine binding site [chemical binding]; other site 1036743008943 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1036743008944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743008945 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1036743008946 active site 1036743008947 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1036743008948 homodimer interface [polypeptide binding]; other site 1036743008949 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1036743008950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743008951 NAD(P) binding site [chemical binding]; other site 1036743008952 active site 1036743008953 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1036743008954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743008955 FeS/SAM binding site; other site 1036743008956 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1036743008957 WbqC-like protein family; Region: WbqC; pfam08889 1036743008958 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1036743008959 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1036743008960 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1036743008961 inhibitor-cofactor binding pocket; inhibition site 1036743008962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743008963 catalytic residue [active] 1036743008964 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1036743008965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743008966 NAD(P) binding site [chemical binding]; other site 1036743008967 active site 1036743008968 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1036743008969 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743008970 Walker A/P-loop; other site 1036743008971 ATP binding site [chemical binding]; other site 1036743008972 Q-loop/lid; other site 1036743008973 ABC transporter signature motif; other site 1036743008974 Walker B; other site 1036743008975 D-loop; other site 1036743008976 H-loop/switch region; other site 1036743008977 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1036743008978 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1036743008979 FtsX-like permease family; Region: FtsX; pfam02687 1036743008980 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743008981 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743008982 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1036743008983 PAS fold; Region: PAS; pfam00989 1036743008984 Histidine kinase; Region: HisKA_2; pfam07568 1036743008985 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1036743008986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743008987 ATP binding site [chemical binding]; other site 1036743008988 Mg2+ binding site [ion binding]; other site 1036743008989 G-X-G motif; other site 1036743008990 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1036743008991 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1036743008992 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1036743008993 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743008994 DNA-binding site [nucleotide binding]; DNA binding site 1036743008995 RNA-binding motif; other site 1036743008996 GAF domain; Region: GAF; cl17456 1036743008997 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1036743008998 dimerization interface [polypeptide binding]; other site 1036743008999 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743009000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743009001 dimer interface [polypeptide binding]; other site 1036743009002 putative CheW interface [polypeptide binding]; other site 1036743009003 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743009004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009005 active site 1036743009006 phosphorylation site [posttranslational modification] 1036743009007 intermolecular recognition site; other site 1036743009008 dimerization interface [polypeptide binding]; other site 1036743009009 hybrid cluster protein; Provisional; Region: PRK05290 1036743009010 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1036743009011 ACS interaction site; other site 1036743009012 CODH interaction site; other site 1036743009013 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1036743009014 hybrid metal cluster; other site 1036743009015 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1036743009016 PAS domain S-box; Region: sensory_box; TIGR00229 1036743009017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743009018 putative active site [active] 1036743009019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743009020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743009021 metal binding site [ion binding]; metal-binding site 1036743009022 active site 1036743009023 I-site; other site 1036743009024 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743009025 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1036743009026 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1036743009027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1036743009028 Peptidase_C39 like family; Region: DUF3335; pfam11814 1036743009029 Domain of unknown function (DUF329); Region: DUF329; pfam03884 1036743009030 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1036743009031 homodimer interface [polypeptide binding]; other site 1036743009032 oligonucleotide binding site [chemical binding]; other site 1036743009033 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1036743009034 Maf-like protein; Region: Maf; pfam02545 1036743009035 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1036743009036 active site 1036743009037 dimer interface [polypeptide binding]; other site 1036743009038 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1036743009039 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1036743009040 active site 1036743009041 hypothetical protein; Provisional; Region: PRK02853 1036743009042 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1036743009043 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1036743009044 NAD binding site [chemical binding]; other site 1036743009045 dimerization interface [polypeptide binding]; other site 1036743009046 product binding site; other site 1036743009047 substrate binding site [chemical binding]; other site 1036743009048 zinc binding site [ion binding]; other site 1036743009049 catalytic residues [active] 1036743009050 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1036743009051 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1036743009052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743009053 dimerization interface [polypeptide binding]; other site 1036743009054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743009055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743009056 dimer interface [polypeptide binding]; other site 1036743009057 putative CheW interface [polypeptide binding]; other site 1036743009058 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1036743009059 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1036743009060 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1036743009061 putative active site pocket [active] 1036743009062 dimerization interface [polypeptide binding]; other site 1036743009063 putative catalytic residue [active] 1036743009064 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1036743009065 EamA-like transporter family; Region: EamA; pfam00892 1036743009066 EamA-like transporter family; Region: EamA; pfam00892 1036743009067 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1036743009068 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1036743009069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743009070 salt bridge; other site 1036743009071 non-specific DNA binding site [nucleotide binding]; other site 1036743009072 sequence-specific DNA binding site [nucleotide binding]; other site 1036743009073 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1036743009074 hypothetical protein; Provisional; Region: PRK02399 1036743009075 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1036743009076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743009077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743009078 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1036743009079 dimerization interface [polypeptide binding]; other site 1036743009080 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1036743009081 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1036743009082 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1036743009083 putative ligand binding site [chemical binding]; other site 1036743009084 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1036743009085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1036743009086 Walker A/P-loop; other site 1036743009087 ATP binding site [chemical binding]; other site 1036743009088 Q-loop/lid; other site 1036743009089 ABC transporter signature motif; other site 1036743009090 Walker B; other site 1036743009091 D-loop; other site 1036743009092 H-loop/switch region; other site 1036743009093 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1036743009094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743009095 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1036743009096 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1036743009097 TM-ABC transporter signature motif; other site 1036743009098 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743009099 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1036743009100 TM-ABC transporter signature motif; other site 1036743009101 cytosine deaminase; Validated; Region: PRK07572 1036743009102 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1036743009103 active site 1036743009104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743009105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1036743009106 putative substrate translocation pore; other site 1036743009107 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1036743009108 MarR family; Region: MarR_2; pfam12802 1036743009109 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1036743009110 trimer interface [polypeptide binding]; other site 1036743009111 active site 1036743009112 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1036743009113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1036743009114 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1036743009115 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1036743009116 trimer interface [polypeptide binding]; other site 1036743009117 active site 1036743009118 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1036743009119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1036743009120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1036743009121 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1036743009122 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1036743009123 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1036743009124 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1036743009125 catalytic residues [active] 1036743009126 Cytochrome c; Region: Cytochrom_C; cl11414 1036743009127 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1036743009128 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1036743009129 catalytic residues [active] 1036743009130 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1036743009131 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743009132 Walker A/P-loop; other site 1036743009133 ATP binding site [chemical binding]; other site 1036743009134 Q-loop/lid; other site 1036743009135 ABC transporter signature motif; other site 1036743009136 Walker B; other site 1036743009137 D-loop; other site 1036743009138 H-loop/switch region; other site 1036743009139 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1036743009140 FtsX-like permease family; Region: FtsX; pfam02687 1036743009141 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1036743009142 Predicted membrane protein [Function unknown]; Region: COG4393 1036743009143 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1036743009144 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1036743009145 Fe2+ transport protein; Region: Iron_transport; pfam10634 1036743009146 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1036743009147 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1036743009148 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1036743009149 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1036743009150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743009151 FeS/SAM binding site; other site 1036743009152 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1036743009153 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1036743009154 GTP binding site; other site 1036743009155 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1036743009156 trimer interface [polypeptide binding]; other site 1036743009157 dimer interface [polypeptide binding]; other site 1036743009158 putative active site [active] 1036743009159 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1036743009160 MoaE interaction surface [polypeptide binding]; other site 1036743009161 MoeB interaction surface [polypeptide binding]; other site 1036743009162 thiocarboxylated glycine; other site 1036743009163 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1036743009164 MoaE homodimer interface [polypeptide binding]; other site 1036743009165 MoaD interaction [polypeptide binding]; other site 1036743009166 active site residues [active] 1036743009167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743009168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743009169 Phasin protein; Region: Phasin_2; pfam09361 1036743009170 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1036743009171 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1036743009172 motif 1; other site 1036743009173 active site 1036743009174 motif 2; other site 1036743009175 motif 3; other site 1036743009176 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1036743009177 recombinase A; Provisional; Region: recA; PRK09354 1036743009178 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1036743009179 hexamer interface [polypeptide binding]; other site 1036743009180 Walker A motif; other site 1036743009181 ATP binding site [chemical binding]; other site 1036743009182 Walker B motif; other site 1036743009183 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1036743009184 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1036743009185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743009186 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743009187 putative active site [active] 1036743009188 heme pocket [chemical binding]; other site 1036743009189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743009190 dimer interface [polypeptide binding]; other site 1036743009191 phosphorylation site [posttranslational modification] 1036743009192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743009193 ATP binding site [chemical binding]; other site 1036743009194 Mg2+ binding site [ion binding]; other site 1036743009195 G-X-G motif; other site 1036743009196 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743009197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009198 active site 1036743009199 phosphorylation site [posttranslational modification] 1036743009200 intermolecular recognition site; other site 1036743009201 dimerization interface [polypeptide binding]; other site 1036743009202 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1036743009203 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1036743009204 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1036743009205 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1036743009206 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 1036743009207 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1036743009208 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1036743009209 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 1036743009210 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1036743009211 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1036743009212 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1036743009213 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1036743009214 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1036743009215 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1036743009216 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1036743009217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009218 active site 1036743009219 phosphorylation site [posttranslational modification] 1036743009220 intermolecular recognition site; other site 1036743009221 dimerization interface [polypeptide binding]; other site 1036743009222 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1036743009223 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 1036743009224 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1036743009225 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1036743009226 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 1036743009227 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1036743009228 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1036743009229 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1036743009230 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1036743009231 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1036743009232 SAF-like; Region: SAF_2; pfam13144 1036743009233 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1036743009234 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1036743009235 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1036743009236 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 1036743009237 Flagellar protein FlaF; Region: FlaF; cl11454 1036743009238 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1036743009239 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 1036743009240 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1036743009241 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1036743009242 Rod binding protein; Region: Rod-binding; cl01626 1036743009243 FlgN protein; Region: FlgN; pfam05130 1036743009244 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1036743009245 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1036743009246 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1036743009247 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 1036743009248 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1036743009249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1036743009250 binding surface 1036743009251 TPR motif; other site 1036743009252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743009253 binding surface 1036743009254 TPR repeat; Region: TPR_11; pfam13414 1036743009255 TPR motif; other site 1036743009256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743009257 binding surface 1036743009258 TPR repeat; Region: TPR_11; pfam13414 1036743009259 TPR motif; other site 1036743009260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743009261 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1036743009262 TPR motif; other site 1036743009263 binding surface 1036743009264 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1036743009265 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1036743009266 Flagellar protein FlaF; Region: FlaF; cl11454 1036743009267 Flagellar protein FlbT; Region: FlbT; pfam07378 1036743009268 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1036743009269 flagellin; Reviewed; Region: PRK12687 1036743009270 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1036743009271 TPR repeat; Region: TPR_11; pfam13414 1036743009272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743009273 binding surface 1036743009274 TPR motif; other site 1036743009275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743009276 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1036743009277 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1036743009278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1036743009279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743009280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743009281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743009282 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1036743009283 EF-hand domain pair; Region: EF_hand_5; pfam13499 1036743009284 Ca2+ binding site [ion binding]; other site 1036743009285 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1036743009286 EF-hand domain pair; Region: EF_hand_5; pfam13499 1036743009287 Ca2+ binding site [ion binding]; other site 1036743009288 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1036743009289 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1036743009290 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1036743009291 active site 1036743009292 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1036743009293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743009294 S-adenosylmethionine binding site [chemical binding]; other site 1036743009295 ornithine cyclodeaminase; Validated; Region: PRK06141 1036743009296 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1036743009297 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743009298 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743009299 metal binding site [ion binding]; metal-binding site 1036743009300 active site 1036743009301 I-site; other site 1036743009302 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1036743009303 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1036743009304 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1036743009305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1036743009306 Transporter associated domain; Region: CorC_HlyC; smart01091 1036743009307 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1036743009308 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1036743009309 metal binding site [ion binding]; metal-binding site 1036743009310 putative dimer interface [polypeptide binding]; other site 1036743009311 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1036743009312 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1036743009313 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 1036743009314 putative ligand binding site [chemical binding]; other site 1036743009315 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1036743009316 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1036743009317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743009318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743009319 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1036743009320 putative effector binding pocket; other site 1036743009321 putative dimerization interface [polypeptide binding]; other site 1036743009322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1036743009323 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1036743009324 active site 1036743009325 catalytic tetrad [active] 1036743009326 threonine dehydratase; Provisional; Region: PRK07334 1036743009327 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1036743009328 tetramer interface [polypeptide binding]; other site 1036743009329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743009330 catalytic residue [active] 1036743009331 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1036743009332 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1036743009333 Predicted integral membrane protein [Function unknown]; Region: COG0392 1036743009334 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1036743009335 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1036743009336 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1036743009337 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1036743009338 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1036743009339 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1036743009340 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1036743009341 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1036743009342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743009343 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1036743009344 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743009345 DNA binding residues [nucleotide binding] 1036743009346 DNA primase, catalytic core; Region: dnaG; TIGR01391 1036743009347 CHC2 zinc finger; Region: zf-CHC2; cl17510 1036743009348 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1036743009349 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1036743009350 active site 1036743009351 metal binding site [ion binding]; metal-binding site 1036743009352 interdomain interaction site; other site 1036743009353 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1036743009354 Yqey-like protein; Region: YqeY; cl17540 1036743009355 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1036743009356 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1036743009357 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1036743009358 catalytic site [active] 1036743009359 subunit interface [polypeptide binding]; other site 1036743009360 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1036743009361 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743009362 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1036743009363 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1036743009364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1036743009365 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1036743009366 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1036743009367 IMP binding site; other site 1036743009368 dimer interface [polypeptide binding]; other site 1036743009369 partial ornithine binding site; other site 1036743009370 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1036743009371 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1036743009372 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1036743009373 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1036743009374 RES domain; Region: RES; smart00953 1036743009375 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1036743009376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1036743009377 ABC-ATPase subunit interface; other site 1036743009378 dimer interface [polypeptide binding]; other site 1036743009379 putative PBP binding regions; other site 1036743009380 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1036743009381 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1036743009382 ABC-ATPase subunit interface; other site 1036743009383 dimer interface [polypeptide binding]; other site 1036743009384 putative PBP binding regions; other site 1036743009385 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1036743009386 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1036743009387 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1036743009388 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1036743009389 metal binding site [ion binding]; metal-binding site 1036743009390 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743009391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743009392 putative DNA binding site [nucleotide binding]; other site 1036743009393 putative Zn2+ binding site [ion binding]; other site 1036743009394 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743009395 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1036743009396 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1036743009397 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1036743009398 catalytic triad [active] 1036743009399 dimer interface [polypeptide binding]; other site 1036743009400 peroxidatic and resolving cysteines [active] 1036743009401 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1036743009402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1036743009403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743009404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1036743009405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743009406 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1036743009407 putative effector binding pocket; other site 1036743009408 dimerization interface [polypeptide binding]; other site 1036743009409 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1036743009410 EamA-like transporter family; Region: EamA; pfam00892 1036743009411 EamA-like transporter family; Region: EamA; pfam00892 1036743009412 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1036743009413 nucleotide binding site/active site [active] 1036743009414 HIT family signature motif; other site 1036743009415 catalytic residue [active] 1036743009416 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1036743009417 DNA photolyase; Region: DNA_photolyase; pfam00875 1036743009418 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1036743009419 EamA-like transporter family; Region: EamA; pfam00892 1036743009420 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743009421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743009422 putative DNA binding site [nucleotide binding]; other site 1036743009423 putative Zn2+ binding site [ion binding]; other site 1036743009424 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743009425 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1036743009426 anti sigma factor interaction site; other site 1036743009427 regulatory phosphorylation site [posttranslational modification]; other site 1036743009428 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1036743009429 Permease; Region: Permease; pfam02405 1036743009430 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1036743009431 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1036743009432 Walker A/P-loop; other site 1036743009433 ATP binding site [chemical binding]; other site 1036743009434 Q-loop/lid; other site 1036743009435 ABC transporter signature motif; other site 1036743009436 Walker B; other site 1036743009437 D-loop; other site 1036743009438 H-loop/switch region; other site 1036743009439 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1036743009440 mce related protein; Region: MCE; pfam02470 1036743009441 Protein of unknown function (DUF330); Region: DUF330; cl01135 1036743009442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743009443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009444 active site 1036743009445 phosphorylation site [posttranslational modification] 1036743009446 intermolecular recognition site; other site 1036743009447 dimerization interface [polypeptide binding]; other site 1036743009448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743009449 DNA binding site [nucleotide binding] 1036743009450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743009451 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1036743009452 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1036743009453 dimer interface [polypeptide binding]; other site 1036743009454 phosphorylation site [posttranslational modification] 1036743009455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743009456 ATP binding site [chemical binding]; other site 1036743009457 Mg2+ binding site [ion binding]; other site 1036743009458 G-X-G motif; other site 1036743009459 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1036743009460 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1036743009461 Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083 1036743009462 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1036743009463 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1036743009464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743009465 binding surface 1036743009466 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1036743009467 TPR motif; other site 1036743009468 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743009469 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1036743009470 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1036743009471 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1036743009472 active site 1036743009473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743009474 H+ Antiporter protein; Region: 2A0121; TIGR00900 1036743009475 putative substrate translocation pore; other site 1036743009476 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1036743009477 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1036743009478 Protein export membrane protein; Region: SecD_SecF; cl14618 1036743009479 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743009480 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743009481 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743009482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743009483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009484 active site 1036743009485 phosphorylation site [posttranslational modification] 1036743009486 intermolecular recognition site; other site 1036743009487 dimerization interface [polypeptide binding]; other site 1036743009488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743009489 DNA binding site [nucleotide binding] 1036743009490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743009491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743009492 dimerization interface [polypeptide binding]; other site 1036743009493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743009494 dimer interface [polypeptide binding]; other site 1036743009495 phosphorylation site [posttranslational modification] 1036743009496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743009497 ATP binding site [chemical binding]; other site 1036743009498 Mg2+ binding site [ion binding]; other site 1036743009499 G-X-G motif; other site 1036743009500 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1036743009501 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1036743009502 hinge; other site 1036743009503 active site 1036743009504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743009505 PAS fold; Region: PAS_4; pfam08448 1036743009506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743009507 putative active site [active] 1036743009508 heme pocket [chemical binding]; other site 1036743009509 PAS fold; Region: PAS_4; pfam08448 1036743009510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743009511 putative active site [active] 1036743009512 heme pocket [chemical binding]; other site 1036743009513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743009514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743009515 dimer interface [polypeptide binding]; other site 1036743009516 phosphorylation site [posttranslational modification] 1036743009517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743009518 ATP binding site [chemical binding]; other site 1036743009519 Mg2+ binding site [ion binding]; other site 1036743009520 G-X-G motif; other site 1036743009521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009522 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743009523 active site 1036743009524 phosphorylation site [posttranslational modification] 1036743009525 intermolecular recognition site; other site 1036743009526 dimerization interface [polypeptide binding]; other site 1036743009527 dihydroorotase; Validated; Region: PRK09060 1036743009528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1036743009529 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1036743009530 active site 1036743009531 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743009532 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1036743009533 dimer interface [polypeptide binding]; other site 1036743009534 active site 1036743009535 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743009536 Ligand Binding Site [chemical binding]; other site 1036743009537 Molecular Tunnel; other site 1036743009538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743009539 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1036743009540 putative ADP-binding pocket [chemical binding]; other site 1036743009541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743009542 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1036743009543 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1036743009544 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1036743009545 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1036743009546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1036743009547 salt bridge; other site 1036743009548 non-specific DNA binding site [nucleotide binding]; other site 1036743009549 sequence-specific DNA binding site [nucleotide binding]; other site 1036743009550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743009551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743009552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743009553 Walker A/P-loop; other site 1036743009554 ATP binding site [chemical binding]; other site 1036743009555 Q-loop/lid; other site 1036743009556 ABC transporter signature motif; other site 1036743009557 Walker B; other site 1036743009558 D-loop; other site 1036743009559 H-loop/switch region; other site 1036743009560 Predicted permeases [General function prediction only]; Region: COG0795 1036743009561 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1036743009562 ArgK protein; Region: ArgK; pfam03308 1036743009563 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743009564 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1036743009565 G4 box; other site 1036743009566 G5 box; other site 1036743009567 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1036743009568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743009569 ATP binding site [chemical binding]; other site 1036743009570 Mg2+ binding site [ion binding]; other site 1036743009571 G-X-G motif; other site 1036743009572 DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119 1036743009573 ATP binding site [chemical binding]; other site 1036743009574 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1036743009575 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1036743009576 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1036743009577 active site 1036743009578 dimer interface [polypeptide binding]; other site 1036743009579 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1036743009580 dimer interface [polypeptide binding]; other site 1036743009581 active site 1036743009582 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1036743009583 putative active site [active] 1036743009584 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1036743009585 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1036743009586 substrate binding pocket [chemical binding]; other site 1036743009587 chain length determination region; other site 1036743009588 substrate-Mg2+ binding site; other site 1036743009589 catalytic residues [active] 1036743009590 aspartate-rich region 1; other site 1036743009591 active site lid residues [active] 1036743009592 aspartate-rich region 2; other site 1036743009593 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1036743009594 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1036743009595 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1036743009596 dimer interface [polypeptide binding]; other site 1036743009597 motif 1; other site 1036743009598 active site 1036743009599 motif 2; other site 1036743009600 motif 3; other site 1036743009601 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1036743009602 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1036743009603 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1036743009604 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1036743009605 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1036743009606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1036743009607 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1036743009608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743009609 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1036743009610 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1036743009611 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1036743009612 NADP binding site [chemical binding]; other site 1036743009613 dimer interface [polypeptide binding]; other site 1036743009614 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1036743009615 dimer interaction site [polypeptide binding]; other site 1036743009616 substrate-binding tunnel; other site 1036743009617 active site 1036743009618 catalytic site [active] 1036743009619 substrate binding site [chemical binding]; other site 1036743009620 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1036743009621 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1036743009622 active site 1036743009623 Riboflavin kinase; Region: Flavokinase; smart00904 1036743009624 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1036743009625 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1036743009626 active site 1036743009627 HIGH motif; other site 1036743009628 nucleotide binding site [chemical binding]; other site 1036743009629 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1036743009630 active site 1036743009631 KMSKS motif; other site 1036743009632 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1036743009633 tRNA binding surface [nucleotide binding]; other site 1036743009634 anticodon binding site; other site 1036743009635 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1036743009636 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1036743009637 lipoprotein signal peptidase; Provisional; Region: PRK14787 1036743009638 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 1036743009639 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1036743009640 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1036743009641 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1036743009642 active site 1036743009643 SAM binding site [chemical binding]; other site 1036743009644 homodimer interface [polypeptide binding]; other site 1036743009645 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1036743009646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743009647 putative substrate translocation pore; other site 1036743009648 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1036743009649 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1036743009650 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1036743009651 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1036743009652 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1036743009653 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1036743009654 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 1036743009655 subunit H interface; other site 1036743009656 subunit L interface; other site 1036743009657 bacteriopheophytin binding site; other site 1036743009658 carotenoid binding site; other site 1036743009659 bacteriochlorophyll binding site; other site 1036743009660 cytochrome C interface; other site 1036743009661 quinone binding site; other site 1036743009662 Fe binding site [ion binding]; other site 1036743009663 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 1036743009664 subunit M interface; other site 1036743009665 subunit H interface; other site 1036743009666 quinone binding site; other site 1036743009667 bacteriopheophytin binding site; other site 1036743009668 bacteriochlorophyll binding site; other site 1036743009669 cytochrome C subunit interface; other site 1036743009670 Fe binding site [ion binding]; other site 1036743009671 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 1036743009672 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 1036743009673 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1036743009674 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 1036743009675 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1036743009676 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 1036743009677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743009678 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 1036743009679 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 1036743009680 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1036743009681 putative NAD(P) binding site [chemical binding]; other site 1036743009682 O-methyltransferase; Region: Methyltransf_2; pfam00891 1036743009683 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1036743009684 substrate binding pocket [chemical binding]; other site 1036743009685 chain length determination region; other site 1036743009686 substrate-Mg2+ binding site; other site 1036743009687 catalytic residues [active] 1036743009688 aspartate-rich region 1; other site 1036743009689 active site lid residues [active] 1036743009690 aspartate-rich region 2; other site 1036743009691 phytoene desaturase; Region: crtI_fam; TIGR02734 1036743009692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1036743009693 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1036743009694 tricarballylate dehydrogenase; Validated; Region: PRK08274 1036743009695 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 1036743009696 CitB domain protein; Region: CitB; TIGR02484 1036743009697 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1036743009698 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1036743009699 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1036743009700 homodimer interface [polypeptide binding]; other site 1036743009701 active site 1036743009702 SAM binding site [chemical binding]; other site 1036743009703 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1036743009704 active site 1036743009705 SAM binding site [chemical binding]; other site 1036743009706 homodimer interface [polypeptide binding]; other site 1036743009707 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1036743009708 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1036743009709 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1036743009710 active site 1036743009711 putative homodimer interface [polypeptide binding]; other site 1036743009712 SAM binding site [chemical binding]; other site 1036743009713 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1036743009714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743009715 S-adenosylmethionine binding site [chemical binding]; other site 1036743009716 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1036743009717 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743009718 P-loop; other site 1036743009719 Magnesium ion binding site [ion binding]; other site 1036743009720 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1036743009721 phosphate acetyltransferase; Reviewed; Region: PRK05632 1036743009722 DRTGG domain; Region: DRTGG; pfam07085 1036743009723 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1036743009724 propionate/acetate kinase; Provisional; Region: PRK12379 1036743009725 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1036743009726 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1036743009727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743009728 FeS/SAM binding site; other site 1036743009729 Pyruvate formate lyase 1; Region: PFL1; cd01678 1036743009730 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1036743009731 coenzyme A binding site [chemical binding]; other site 1036743009732 active site 1036743009733 catalytic residues [active] 1036743009734 glycine loop; other site 1036743009735 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1036743009736 Carbon starvation protein CstA; Region: CstA; pfam02554 1036743009737 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1036743009738 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1036743009739 Isochorismatase family; Region: Isochorismatase; pfam00857 1036743009740 catalytic triad [active] 1036743009741 metal binding site [ion binding]; metal-binding site 1036743009742 conserved cis-peptide bond; other site 1036743009743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743009744 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1036743009745 DNA-binding site [nucleotide binding]; DNA binding site 1036743009746 FCD domain; Region: FCD; pfam07729 1036743009747 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1036743009748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743009749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743009750 homodimer interface [polypeptide binding]; other site 1036743009751 catalytic residue [active] 1036743009752 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1036743009753 Rubredoxin; Region: Rubredoxin; pfam00301 1036743009754 iron binding site [ion binding]; other site 1036743009755 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1036743009756 SOUL heme-binding protein; Region: SOUL; pfam04832 1036743009757 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1036743009758 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743009759 inhibitor-cofactor binding pocket; inhibition site 1036743009760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743009761 catalytic residue [active] 1036743009762 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1036743009763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743009764 DNA-binding site [nucleotide binding]; DNA binding site 1036743009765 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1036743009766 Isochorismatase family; Region: Isochorismatase; pfam00857 1036743009767 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1036743009768 catalytic triad [active] 1036743009769 conserved cis-peptide bond; other site 1036743009770 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1036743009771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743009772 dimer interface [polypeptide binding]; other site 1036743009773 conserved gate region; other site 1036743009774 putative PBP binding loops; other site 1036743009775 ABC-ATPase subunit interface; other site 1036743009776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743009777 dimer interface [polypeptide binding]; other site 1036743009778 conserved gate region; other site 1036743009779 ABC-ATPase subunit interface; other site 1036743009780 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1036743009781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743009782 Walker A/P-loop; other site 1036743009783 ATP binding site [chemical binding]; other site 1036743009784 Q-loop/lid; other site 1036743009785 ABC transporter signature motif; other site 1036743009786 Walker B; other site 1036743009787 D-loop; other site 1036743009788 H-loop/switch region; other site 1036743009789 TOBE domain; Region: TOBE_2; pfam08402 1036743009790 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1036743009791 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1036743009792 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1036743009793 active site 1036743009794 substrate binding site [chemical binding]; other site 1036743009795 ATP binding site [chemical binding]; other site 1036743009796 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1036743009797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743009798 NAD(P) binding site [chemical binding]; other site 1036743009799 active site 1036743009800 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 1036743009801 General stress protein [General function prediction only]; Region: GsiB; COG3729 1036743009802 General stress protein [General function prediction only]; Region: GsiB; COG3729 1036743009803 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1036743009804 Nuclease-related domain; Region: NERD; pfam08378 1036743009805 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1036743009806 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1036743009807 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1036743009808 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1036743009809 active site 1036743009810 metal-binding site [ion binding] 1036743009811 nucleotide-binding site [chemical binding]; other site 1036743009812 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1036743009813 sulfotransferase; Region: PLN02164 1036743009814 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1036743009815 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743009816 Ligand Binding Site [chemical binding]; other site 1036743009817 Molecular Tunnel; other site 1036743009818 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1036743009819 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1036743009820 glutaminase active site [active] 1036743009821 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1036743009822 dimer interface [polypeptide binding]; other site 1036743009823 active site 1036743009824 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1036743009825 dimer interface [polypeptide binding]; other site 1036743009826 active site 1036743009827 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1036743009828 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1036743009829 Substrate binding site; other site 1036743009830 Mg++ binding site; other site 1036743009831 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1036743009832 active site 1036743009833 substrate binding site [chemical binding]; other site 1036743009834 CoA binding site [chemical binding]; other site 1036743009835 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1036743009836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743009837 motif II; other site 1036743009838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1036743009839 hypothetical protein; Validated; Region: PRK06217 1036743009840 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1036743009841 EamA-like transporter family; Region: EamA; pfam00892 1036743009842 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1036743009843 Catalytic site; other site 1036743009844 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1036743009845 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1036743009846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743009847 putative CheW interface [polypeptide binding]; other site 1036743009848 tellurite resistance protein terB; Region: terB; cd07176 1036743009849 putative metal binding site [ion binding]; other site 1036743009850 GAF domain; Region: GAF_2; pfam13185 1036743009851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743009852 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1036743009853 putative active site [active] 1036743009854 heme pocket [chemical binding]; other site 1036743009855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743009856 dimer interface [polypeptide binding]; other site 1036743009857 phosphorylation site [posttranslational modification] 1036743009858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743009859 ATP binding site [chemical binding]; other site 1036743009860 Mg2+ binding site [ion binding]; other site 1036743009861 G-X-G motif; other site 1036743009862 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743009863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009864 active site 1036743009865 phosphorylation site [posttranslational modification] 1036743009866 intermolecular recognition site; other site 1036743009867 dimerization interface [polypeptide binding]; other site 1036743009868 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743009869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743009870 active site 1036743009871 phosphorylation site [posttranslational modification] 1036743009872 intermolecular recognition site; other site 1036743009873 dimerization interface [polypeptide binding]; other site 1036743009874 kynureninase; Region: kynureninase; TIGR01814 1036743009875 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1036743009876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743009877 catalytic residue [active] 1036743009878 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1036743009879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743009880 DNA-binding site [nucleotide binding]; DNA binding site 1036743009881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743009882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743009883 homodimer interface [polypeptide binding]; other site 1036743009884 catalytic residue [active] 1036743009885 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743009886 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1036743009887 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1036743009888 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1036743009889 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1036743009890 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1036743009891 tetramer interface [polypeptide binding]; other site 1036743009892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743009893 catalytic residue [active] 1036743009894 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 1036743009895 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1036743009896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1036743009897 catalytic residue [active] 1036743009898 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1036743009899 lipoyl attachment site [posttranslational modification]; other site 1036743009900 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1036743009901 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1036743009902 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1036743009903 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1036743009904 putative active site [active] 1036743009905 putative substrate binding site [chemical binding]; other site 1036743009906 ATP binding site [chemical binding]; other site 1036743009907 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1036743009908 RNA/DNA hybrid binding site [nucleotide binding]; other site 1036743009909 active site 1036743009910 aromatic amino acid exporter; Provisional; Region: PRK11689 1036743009911 EamA-like transporter family; Region: EamA; cl17759 1036743009912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743009913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1036743009914 putative substrate translocation pore; other site 1036743009915 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1036743009916 catalytic triad [active] 1036743009917 dimer interface [polypeptide binding]; other site 1036743009918 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1036743009919 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1036743009920 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1036743009921 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1036743009922 DsbD alpha interface [polypeptide binding]; other site 1036743009923 catalytic residues [active] 1036743009924 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1036743009925 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1036743009926 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1036743009927 B12 binding site [chemical binding]; other site 1036743009928 cobalt ligand [ion binding]; other site 1036743009929 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 1036743009930 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1036743009931 putative NAD(P) binding site [chemical binding]; other site 1036743009932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1036743009933 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1036743009934 active site 1036743009935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743009936 non-specific DNA binding site [nucleotide binding]; other site 1036743009937 salt bridge; other site 1036743009938 sequence-specific DNA binding site [nucleotide binding]; other site 1036743009939 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1036743009940 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1036743009941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743009942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743009943 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1036743009944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743009945 non-specific DNA binding site [nucleotide binding]; other site 1036743009946 salt bridge; other site 1036743009947 sequence-specific DNA binding site [nucleotide binding]; other site 1036743009948 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1036743009949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743009950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743009951 dimerization interface [polypeptide binding]; other site 1036743009952 putative DNA binding site [nucleotide binding]; other site 1036743009953 putative Zn2+ binding site [ion binding]; other site 1036743009954 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743009955 EamA-like transporter family; Region: EamA; pfam00892 1036743009956 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1036743009957 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1036743009958 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1036743009959 active site 1036743009960 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1036743009961 Predicted permeases [General function prediction only]; Region: COG0795 1036743009962 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1036743009963 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1036743009964 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1036743009965 Ligand binding site [chemical binding]; other site 1036743009966 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1036743009967 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1036743009968 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1036743009969 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1036743009970 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1036743009971 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1036743009972 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1036743009973 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1036743009974 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1036743009975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743009976 non-specific DNA binding site [nucleotide binding]; other site 1036743009977 sequence-specific DNA binding site [nucleotide binding]; other site 1036743009978 salt bridge; other site 1036743009979 Predicted flavoprotein [General function prediction only]; Region: COG0431 1036743009980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1036743009981 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 1036743009982 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1036743009983 G1 box; other site 1036743009984 GTP/Mg2+ binding site [chemical binding]; other site 1036743009985 Switch I region; other site 1036743009986 G2 box; other site 1036743009987 Switch II region; other site 1036743009988 G3 box; other site 1036743009989 G4 box; other site 1036743009990 G5 box; other site 1036743009991 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1036743009992 G1 box; other site 1036743009993 GTP/Mg2+ binding site [chemical binding]; other site 1036743009994 Switch I region; other site 1036743009995 G2 box; other site 1036743009996 G3 box; other site 1036743009997 Switch II region; other site 1036743009998 G4 box; other site 1036743009999 G5 box; other site 1036743010000 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1036743010001 Trp docking motif [polypeptide binding]; other site 1036743010002 active site 1036743010003 PQQ-like domain; Region: PQQ_2; pfam13360 1036743010004 PQQ-like domain; Region: PQQ_2; pfam13360 1036743010005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1036743010006 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 1036743010007 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1036743010008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1036743010009 active site 1036743010010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743010011 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1036743010012 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1036743010013 putative active site [active] 1036743010014 putative catalytic site [active] 1036743010015 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1036743010016 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1036743010017 probable O-glycosylation ligase, exosortase A-associated; Region: PEP_O_lig_1; TIGR03097 1036743010018 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1036743010019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743010020 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1036743010021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743010022 TPR motif; other site 1036743010023 binding surface 1036743010024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743010025 TPR motif; other site 1036743010026 binding surface 1036743010027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1036743010028 TPR motif; other site 1036743010029 binding surface 1036743010030 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 1036743010031 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1036743010032 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 1036743010033 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1036743010034 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 1036743010035 GAF domain; Region: GAF_3; pfam13492 1036743010036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1036743010037 dimer interface [polypeptide binding]; other site 1036743010038 phosphorylation site [posttranslational modification] 1036743010039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010040 ATP binding site [chemical binding]; other site 1036743010041 Mg2+ binding site [ion binding]; other site 1036743010042 G-X-G motif; other site 1036743010043 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 1036743010044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743010045 active site 1036743010046 phosphorylation site [posttranslational modification] 1036743010047 intermolecular recognition site; other site 1036743010048 dimerization interface [polypeptide binding]; other site 1036743010049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743010050 Walker A motif; other site 1036743010051 ATP binding site [chemical binding]; other site 1036743010052 Walker B motif; other site 1036743010053 arginine finger; other site 1036743010054 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1036743010055 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1036743010056 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1036743010057 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1036743010058 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1036743010059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1036743010060 NAD(P) binding site [chemical binding]; other site 1036743010061 active site 1036743010062 acyl-CoA synthetase; Validated; Region: PRK05850 1036743010063 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1036743010064 acyl-activating enzyme (AAE) consensus motif; other site 1036743010065 active site 1036743010066 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1036743010067 Condensation domain; Region: Condensation; pfam00668 1036743010068 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1036743010069 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1036743010070 acyl-activating enzyme (AAE) consensus motif; other site 1036743010071 AMP binding site [chemical binding]; other site 1036743010072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1036743010073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743010074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743010075 ligand binding site [chemical binding]; other site 1036743010076 flexible hinge region; other site 1036743010077 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1036743010078 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1036743010079 active site 1036743010080 nucleophile elbow; other site 1036743010081 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1036743010082 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1036743010083 active site 1036743010084 metal binding site [ion binding]; metal-binding site 1036743010085 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1036743010086 FAD binding domain; Region: FAD_binding_4; pfam01565 1036743010087 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 1036743010088 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 1036743010089 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 1036743010090 putative active site [active] 1036743010091 putative catalytic site [active] 1036743010092 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1036743010093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743010094 Walker A motif; other site 1036743010095 ATP binding site [chemical binding]; other site 1036743010096 Walker B motif; other site 1036743010097 arginine finger; other site 1036743010098 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 1036743010099 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1036743010100 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1036743010101 SLBB domain; Region: SLBB; pfam10531 1036743010102 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1036743010103 Chain length determinant protein; Region: Wzz; pfam02706 1036743010104 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1036743010105 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743010106 exosortase A; Region: exosortase_1; TIGR03109 1036743010107 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1036743010108 EpsI family protein; Region: EpsI_fam; TIGR02914 1036743010109 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1036743010110 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1036743010111 active site 1036743010112 dimer interface [polypeptide binding]; other site 1036743010113 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1036743010114 Ligand Binding Site [chemical binding]; other site 1036743010115 Molecular Tunnel; other site 1036743010116 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1036743010117 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 1036743010118 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 1036743010119 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1036743010120 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1036743010121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1036743010122 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1036743010123 Helix-turn-helix domain; Region: HTH_18; pfam12833 1036743010124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743010125 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1036743010126 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1036743010127 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1036743010128 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1036743010129 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1036743010130 Walker A/P-loop; other site 1036743010131 ATP binding site [chemical binding]; other site 1036743010132 Q-loop/lid; other site 1036743010133 ABC transporter signature motif; other site 1036743010134 Walker B; other site 1036743010135 D-loop; other site 1036743010136 H-loop/switch region; other site 1036743010137 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743010138 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1036743010139 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1036743010140 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1036743010141 PAS fold; Region: PAS_3; pfam08447 1036743010142 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743010143 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743010144 metal binding site [ion binding]; metal-binding site 1036743010145 active site 1036743010146 I-site; other site 1036743010147 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 1036743010148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1036743010149 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 1036743010150 acyl-activating enzyme (AAE) consensus motif; other site 1036743010151 acyl-activating enzyme (AAE) consensus motif; other site 1036743010152 putative AMP binding site [chemical binding]; other site 1036743010153 putative active site [active] 1036743010154 putative CoA binding site [chemical binding]; other site 1036743010155 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1036743010156 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1036743010157 dimer interface [polypeptide binding]; other site 1036743010158 active site 1036743010159 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743010160 catalytic residues [active] 1036743010161 substrate binding site [chemical binding]; other site 1036743010162 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1036743010163 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743010164 P-loop; other site 1036743010165 Magnesium ion binding site [ion binding]; other site 1036743010166 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743010167 PAS domain; Region: PAS; smart00091 1036743010168 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1036743010169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010170 putative active site [active] 1036743010171 heme pocket [chemical binding]; other site 1036743010172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010173 PAS domain; Region: PAS_9; pfam13426 1036743010174 putative active site [active] 1036743010175 heme pocket [chemical binding]; other site 1036743010176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743010177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743010178 metal binding site [ion binding]; metal-binding site 1036743010179 active site 1036743010180 I-site; other site 1036743010181 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743010182 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1036743010183 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1036743010184 putative ligand binding site [chemical binding]; other site 1036743010185 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1036743010186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743010187 DNA-binding site [nucleotide binding]; DNA binding site 1036743010188 FCD domain; Region: FCD; pfam07729 1036743010189 GntP family permease; Region: GntP_permease; pfam02447 1036743010190 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1036743010191 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1036743010192 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1036743010193 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1036743010194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1036743010195 putative aldolase; Validated; Region: PRK08130 1036743010196 intersubunit interface [polypeptide binding]; other site 1036743010197 active site 1036743010198 Zn2+ binding site [ion binding]; other site 1036743010199 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1036743010200 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1036743010201 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1036743010202 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1036743010203 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1036743010204 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1036743010205 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1036743010206 FtsX-like permease family; Region: FtsX; pfam02687 1036743010207 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1036743010208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743010209 Walker A/P-loop; other site 1036743010210 ATP binding site [chemical binding]; other site 1036743010211 Q-loop/lid; other site 1036743010212 ABC transporter signature motif; other site 1036743010213 Walker B; other site 1036743010214 D-loop; other site 1036743010215 H-loop/switch region; other site 1036743010216 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1036743010217 metal ion-dependent adhesion site (MIDAS); other site 1036743010218 Inositol 1,4,5-trisphosphate/ryanodine receptor; Region: Ins145_P3_rec; pfam08709 1036743010219 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1036743010220 Virulence factor SrfB; Region: SrfB; pfam07520 1036743010221 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1036743010222 metal ion-dependent adhesion site (MIDAS); other site 1036743010223 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1036743010224 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1036743010225 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1036743010226 metabolite-proton symporter; Region: 2A0106; TIGR00883 1036743010227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743010228 putative substrate translocation pore; other site 1036743010229 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1036743010230 EamA-like transporter family; Region: EamA; pfam00892 1036743010231 prephenate dehydratase; Provisional; Region: PRK11899 1036743010232 Prephenate dehydratase; Region: PDT; pfam00800 1036743010233 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1036743010234 putative L-Phe binding site [chemical binding]; other site 1036743010235 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1036743010236 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1036743010237 Ligand binding site; other site 1036743010238 oligomer interface; other site 1036743010239 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 1036743010240 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1036743010241 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1036743010242 active site 1036743010243 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1036743010244 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1036743010245 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1036743010246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743010247 dimer interface [polypeptide binding]; other site 1036743010248 conserved gate region; other site 1036743010249 putative PBP binding loops; other site 1036743010250 ABC-ATPase subunit interface; other site 1036743010251 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1036743010252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743010253 dimer interface [polypeptide binding]; other site 1036743010254 conserved gate region; other site 1036743010255 putative PBP binding loops; other site 1036743010256 ABC-ATPase subunit interface; other site 1036743010257 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1036743010258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743010259 Walker A/P-loop; other site 1036743010260 ATP binding site [chemical binding]; other site 1036743010261 Q-loop/lid; other site 1036743010262 ABC transporter signature motif; other site 1036743010263 Walker B; other site 1036743010264 D-loop; other site 1036743010265 H-loop/switch region; other site 1036743010266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1036743010267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1036743010268 Walker A/P-loop; other site 1036743010269 ATP binding site [chemical binding]; other site 1036743010270 Q-loop/lid; other site 1036743010271 ABC transporter signature motif; other site 1036743010272 Walker B; other site 1036743010273 D-loop; other site 1036743010274 H-loop/switch region; other site 1036743010275 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1036743010276 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1036743010277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743010278 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1036743010279 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1036743010280 GatB domain; Region: GatB_Yqey; smart00845 1036743010281 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1036743010282 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1036743010283 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1036743010284 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1036743010285 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1036743010286 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1036743010287 GAF domain; Region: GAF; cl17456 1036743010288 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1036743010289 Zn2+ binding site [ion binding]; other site 1036743010290 Mg2+ binding site [ion binding]; other site 1036743010291 Predicted membrane protein [Function unknown]; Region: COG5373 1036743010292 Predicted permeases [General function prediction only]; Region: COG0679 1036743010293 Dihaem cytochrome c; Region: DHC; pfam09626 1036743010294 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 1036743010295 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1036743010296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743010297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743010298 active site 1036743010299 phosphorylation site [posttranslational modification] 1036743010300 intermolecular recognition site; other site 1036743010301 dimerization interface [polypeptide binding]; other site 1036743010302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743010303 DNA binding site [nucleotide binding] 1036743010304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743010305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010306 ATP binding site [chemical binding]; other site 1036743010307 Mg2+ binding site [ion binding]; other site 1036743010308 G-X-G motif; other site 1036743010309 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1036743010310 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1036743010311 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1036743010312 dihydroorotase; Validated; Region: PRK09059 1036743010313 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1036743010314 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1036743010315 active site 1036743010316 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1036743010317 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1036743010318 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1036743010319 putative C-terminal domain interface [polypeptide binding]; other site 1036743010320 putative GSH binding site (G-site) [chemical binding]; other site 1036743010321 putative dimer interface [polypeptide binding]; other site 1036743010322 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1036743010323 putative N-terminal domain interface [polypeptide binding]; other site 1036743010324 putative substrate binding pocket (H-site) [chemical binding]; other site 1036743010325 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1036743010326 DNA protecting protein DprA; Region: dprA; TIGR00732 1036743010327 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 1036743010328 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1036743010329 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1036743010330 HicB family; Region: HicB; pfam05534 1036743010331 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1036743010332 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1036743010333 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1036743010334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743010335 dimer interface [polypeptide binding]; other site 1036743010336 putative PBP binding loops; other site 1036743010337 ABC-ATPase subunit interface; other site 1036743010338 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1036743010339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743010340 Walker A/P-loop; other site 1036743010341 ATP binding site [chemical binding]; other site 1036743010342 Q-loop/lid; other site 1036743010343 ABC transporter signature motif; other site 1036743010344 Walker B; other site 1036743010345 D-loop; other site 1036743010346 H-loop/switch region; other site 1036743010347 TOBE domain; Region: TOBE_2; pfam08402 1036743010348 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1036743010349 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1036743010350 active site 1036743010351 interdomain interaction site; other site 1036743010352 putative metal-binding site [ion binding]; other site 1036743010353 nucleotide binding site [chemical binding]; other site 1036743010354 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1036743010355 domain I; other site 1036743010356 DNA binding groove [nucleotide binding] 1036743010357 phosphate binding site [ion binding]; other site 1036743010358 domain II; other site 1036743010359 domain III; other site 1036743010360 nucleotide binding site [chemical binding]; other site 1036743010361 catalytic site [active] 1036743010362 domain IV; other site 1036743010363 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1036743010364 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1036743010365 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1036743010366 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1036743010367 ribonuclease R; Region: RNase_R; TIGR02063 1036743010368 RNB domain; Region: RNB; pfam00773 1036743010369 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1036743010370 RNA binding site [nucleotide binding]; other site 1036743010371 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1036743010372 protein binding site [polypeptide binding]; other site 1036743010373 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1036743010374 Catalytic dyad [active] 1036743010375 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1036743010376 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743010377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743010378 active site 1036743010379 phosphorylation site [posttranslational modification] 1036743010380 intermolecular recognition site; other site 1036743010381 dimerization interface [polypeptide binding]; other site 1036743010382 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1036743010383 Domain of unknown function DUF29; Region: DUF29; pfam01724 1036743010384 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1036743010385 RNA/DNA hybrid binding site [nucleotide binding]; other site 1036743010386 active site 1036743010387 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1036743010388 DNA methylase; Region: N6_N4_Mtase; pfam01555 1036743010389 Hemerythrin; Region: Hemerythrin; cd12107 1036743010390 Fe binding site [ion binding]; other site 1036743010391 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1036743010392 PAS fold; Region: PAS_7; pfam12860 1036743010393 PAS domain S-box; Region: sensory_box; TIGR00229 1036743010394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010395 putative active site [active] 1036743010396 heme pocket [chemical binding]; other site 1036743010397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010398 PAS fold; Region: PAS_3; pfam08447 1036743010399 putative active site [active] 1036743010400 heme pocket [chemical binding]; other site 1036743010401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743010402 dimer interface [polypeptide binding]; other site 1036743010403 phosphorylation site [posttranslational modification] 1036743010404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010405 ATP binding site [chemical binding]; other site 1036743010406 Mg2+ binding site [ion binding]; other site 1036743010407 G-X-G motif; other site 1036743010408 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1036743010409 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1036743010410 homodimer interface [polypeptide binding]; other site 1036743010411 substrate-cofactor binding pocket; other site 1036743010412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743010413 catalytic residue [active] 1036743010414 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1036743010415 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1036743010416 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1036743010417 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1036743010418 putative metal binding site [ion binding]; other site 1036743010419 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1036743010420 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1036743010421 N-terminal plug; other site 1036743010422 ligand-binding site [chemical binding]; other site 1036743010423 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1036743010424 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1036743010425 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1036743010426 dimer interface [polypeptide binding]; other site 1036743010427 putative PBP binding regions; other site 1036743010428 ABC-ATPase subunit interface; other site 1036743010429 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1036743010430 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1036743010431 Walker A/P-loop; other site 1036743010432 ATP binding site [chemical binding]; other site 1036743010433 Q-loop/lid; other site 1036743010434 ABC transporter signature motif; other site 1036743010435 Walker B; other site 1036743010436 D-loop; other site 1036743010437 H-loop/switch region; other site 1036743010438 RES domain; Region: RES; smart00953 1036743010439 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1036743010440 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1036743010441 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1036743010442 NAD binding site [chemical binding]; other site 1036743010443 homotetramer interface [polypeptide binding]; other site 1036743010444 homodimer interface [polypeptide binding]; other site 1036743010445 substrate binding site [chemical binding]; other site 1036743010446 active site 1036743010447 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1036743010448 putative coenzyme Q binding site [chemical binding]; other site 1036743010449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1036743010450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743010451 active site 1036743010452 phosphorylation site [posttranslational modification] 1036743010453 intermolecular recognition site; other site 1036743010454 dimerization interface [polypeptide binding]; other site 1036743010455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743010456 DNA binding residues [nucleotide binding] 1036743010457 dimerization interface [polypeptide binding]; other site 1036743010458 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743010459 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1036743010460 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743010461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743010462 metal binding site [ion binding]; metal-binding site 1036743010463 active site 1036743010464 I-site; other site 1036743010465 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1036743010466 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1036743010467 conserved cys residue [active] 1036743010468 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1036743010469 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1036743010470 active site 1036743010471 Zn binding site [ion binding]; other site 1036743010472 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1036743010473 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1036743010474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743010475 catalytic residue [active] 1036743010476 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1036743010477 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1036743010478 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1036743010479 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1036743010480 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743010481 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743010482 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1036743010483 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743010484 Walker A/P-loop; other site 1036743010485 ATP binding site [chemical binding]; other site 1036743010486 Q-loop/lid; other site 1036743010487 ABC transporter signature motif; other site 1036743010488 Walker B; other site 1036743010489 D-loop; other site 1036743010490 H-loop/switch region; other site 1036743010491 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1036743010492 FtsX-like permease family; Region: FtsX; pfam02687 1036743010493 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1036743010494 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1036743010495 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1036743010496 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1036743010497 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1036743010498 heme-binding site [chemical binding]; other site 1036743010499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743010500 dimer interface [polypeptide binding]; other site 1036743010501 putative CheW interface [polypeptide binding]; other site 1036743010502 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743010503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743010504 non-specific DNA binding site [nucleotide binding]; other site 1036743010505 salt bridge; other site 1036743010506 sequence-specific DNA binding site [nucleotide binding]; other site 1036743010507 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 1036743010508 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1036743010509 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1036743010510 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1036743010511 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1036743010512 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1036743010513 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1036743010514 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1036743010515 Walker A/P-loop; other site 1036743010516 ATP binding site [chemical binding]; other site 1036743010517 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1036743010518 ABC transporter signature motif; other site 1036743010519 Walker B; other site 1036743010520 D-loop; other site 1036743010521 H-loop/switch region; other site 1036743010522 Thioredoxin; Region: Thioredoxin_4; pfam13462 1036743010523 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1036743010524 Protein of unknown function (DUF721); Region: DUF721; cl02324 1036743010525 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1036743010526 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1036743010527 minor groove reading motif; other site 1036743010528 helix-hairpin-helix signature motif; other site 1036743010529 substrate binding pocket [chemical binding]; other site 1036743010530 active site 1036743010531 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1036743010532 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1036743010533 DNA binding and oxoG recognition site [nucleotide binding] 1036743010534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1036743010535 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1036743010536 NAD binding site [chemical binding]; other site 1036743010537 putative substrate binding site 2 [chemical binding]; other site 1036743010538 putative substrate binding site 1 [chemical binding]; other site 1036743010539 active site 1036743010540 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1036743010541 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1036743010542 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1036743010543 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743010544 Walker A/P-loop; other site 1036743010545 ATP binding site [chemical binding]; other site 1036743010546 Q-loop/lid; other site 1036743010547 ABC transporter signature motif; other site 1036743010548 Walker B; other site 1036743010549 D-loop; other site 1036743010550 H-loop/switch region; other site 1036743010551 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1036743010552 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1036743010553 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1036743010554 putative active site [active] 1036743010555 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1036743010556 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1036743010557 putative acyl-acceptor binding pocket; other site 1036743010558 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1036743010559 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1036743010560 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1036743010561 active site 1036743010562 dimer interface [polypeptide binding]; other site 1036743010563 effector binding site; other site 1036743010564 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1036743010565 putative active site pocket [active] 1036743010566 dimerization interface [polypeptide binding]; other site 1036743010567 putative catalytic residue [active] 1036743010568 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 1036743010569 CHAT domain; Region: CHAT; pfam12770 1036743010570 AAA ATPase domain; Region: AAA_16; pfam13191 1036743010571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743010572 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1036743010573 prephenate dehydrogenase; Validated; Region: PRK08507 1036743010574 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1036743010575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743010576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743010577 homodimer interface [polypeptide binding]; other site 1036743010578 catalytic residue [active] 1036743010579 hypothetical protein; Provisional; Region: PRK06034 1036743010580 Chorismate mutase type II; Region: CM_2; cl00693 1036743010581 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1036743010582 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1036743010583 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743010584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743010585 S-adenosylmethionine binding site [chemical binding]; other site 1036743010586 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1036743010587 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1036743010588 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1036743010589 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1036743010590 putative glutathione S-transferase; Provisional; Region: PRK10357 1036743010591 putative C-terminal domain interface [polypeptide binding]; other site 1036743010592 putative GSH binding site (G-site) [chemical binding]; other site 1036743010593 putative dimer interface [polypeptide binding]; other site 1036743010594 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1036743010595 dimer interface [polypeptide binding]; other site 1036743010596 N-terminal domain interface [polypeptide binding]; other site 1036743010597 putative substrate binding pocket (H-site) [chemical binding]; other site 1036743010598 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1036743010599 EamA-like transporter family; Region: EamA; pfam00892 1036743010600 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1036743010601 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1036743010602 CGNR zinc finger; Region: zf-CGNR; pfam11706 1036743010603 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1036743010604 dimerization interface [polypeptide binding]; other site 1036743010605 domain crossover interface; other site 1036743010606 redox-dependent activation switch; other site 1036743010607 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1036743010608 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1036743010609 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1036743010610 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1036743010611 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743010612 inhibitor-cofactor binding pocket; inhibition site 1036743010613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743010614 catalytic residue [active] 1036743010615 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1036743010616 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1036743010617 NADP binding site [chemical binding]; other site 1036743010618 homopentamer interface [polypeptide binding]; other site 1036743010619 substrate binding site [chemical binding]; other site 1036743010620 active site 1036743010621 Membrane fusogenic activity; Region: BMFP; pfam04380 1036743010622 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1036743010623 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1036743010624 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1036743010625 phasin family protein; Region: phasin; TIGR01841 1036743010626 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1036743010627 dimer interface [polypeptide binding]; other site 1036743010628 putative tRNA-binding site [nucleotide binding]; other site 1036743010629 two-component response regulator; Provisional; Region: PRK09191 1036743010630 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1036743010631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743010632 active site 1036743010633 phosphorylation site [posttranslational modification] 1036743010634 intermolecular recognition site; other site 1036743010635 dimerization interface [polypeptide binding]; other site 1036743010636 RNA polymerase sigma factor; Provisional; Region: PRK12547 1036743010637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1036743010638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1036743010639 DNA binding residues [nucleotide binding] 1036743010640 HAMP domain; Region: HAMP; pfam00672 1036743010641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1036743010642 Histidine kinase; Region: HisKA_2; pfam07568 1036743010643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010644 ATP binding site [chemical binding]; other site 1036743010645 Mg2+ binding site [ion binding]; other site 1036743010646 G-X-G motif; other site 1036743010647 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1036743010648 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1036743010649 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1036743010650 putative active site [active] 1036743010651 putative metal binding site [ion binding]; other site 1036743010652 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1036743010653 active site 1036743010654 metal binding site [ion binding]; metal-binding site 1036743010655 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1036743010656 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1036743010657 tetramer interface [polypeptide binding]; other site 1036743010658 dimer interface [polypeptide binding]; other site 1036743010659 circadian clock protein KaiC; Reviewed; Region: PRK09302 1036743010660 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743010661 Walker A motif; other site 1036743010662 ATP binding site [chemical binding]; other site 1036743010663 Walker B motif; other site 1036743010664 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743010665 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1036743010666 Walker A motif; other site 1036743010667 Walker A motif; other site 1036743010668 ATP binding site [chemical binding]; other site 1036743010669 Walker B motif; other site 1036743010670 PAS domain S-box; Region: sensory_box; TIGR00229 1036743010671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010672 putative active site [active] 1036743010673 heme pocket [chemical binding]; other site 1036743010674 PAS domain; Region: PAS_9; pfam13426 1036743010675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010676 putative active site [active] 1036743010677 heme pocket [chemical binding]; other site 1036743010678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743010679 dimer interface [polypeptide binding]; other site 1036743010680 phosphorylation site [posttranslational modification] 1036743010681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010682 ATP binding site [chemical binding]; other site 1036743010683 Mg2+ binding site [ion binding]; other site 1036743010684 G-X-G motif; other site 1036743010685 AzlC protein; Region: AzlC; pfam03591 1036743010686 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1036743010687 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1036743010688 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1036743010689 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1036743010690 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1036743010691 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1036743010692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 1036743010693 Putative glucoamylase; Region: Glycoamylase; pfam10091 1036743010694 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1036743010695 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1036743010696 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1036743010697 putative ligand binding site [chemical binding]; other site 1036743010698 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1036743010699 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1036743010700 Walker A/P-loop; other site 1036743010701 ATP binding site [chemical binding]; other site 1036743010702 Q-loop/lid; other site 1036743010703 ABC transporter signature motif; other site 1036743010704 Walker B; other site 1036743010705 D-loop; other site 1036743010706 H-loop/switch region; other site 1036743010707 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1036743010708 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1036743010709 Walker A/P-loop; other site 1036743010710 ATP binding site [chemical binding]; other site 1036743010711 Q-loop/lid; other site 1036743010712 ABC transporter signature motif; other site 1036743010713 Walker B; other site 1036743010714 D-loop; other site 1036743010715 H-loop/switch region; other site 1036743010716 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743010717 TM-ABC transporter signature motif; other site 1036743010718 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1036743010719 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1036743010720 TM-ABC transporter signature motif; other site 1036743010721 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1036743010722 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1036743010723 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1036743010724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743010725 non-specific DNA binding site [nucleotide binding]; other site 1036743010726 salt bridge; other site 1036743010727 sequence-specific DNA binding site [nucleotide binding]; other site 1036743010728 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1036743010729 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1036743010730 catalytic residues [active] 1036743010731 catalytic nucleophile [active] 1036743010732 major capsid protein; Region: PHA00201 1036743010733 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1036743010734 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1036743010735 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1036743010736 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1036743010737 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 1036743010738 Int/Topo IB signature motif; other site 1036743010739 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1036743010740 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1036743010741 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1036743010742 active site 1036743010743 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1036743010744 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1036743010745 active site 1036743010746 ATP-binding site [chemical binding]; other site 1036743010747 pantoate-binding site; other site 1036743010748 HXXH motif; other site 1036743010749 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1036743010750 oligomerization interface [polypeptide binding]; other site 1036743010751 active site 1036743010752 metal binding site [ion binding]; metal-binding site 1036743010753 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743010754 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743010755 ligand binding site [chemical binding]; other site 1036743010756 flexible hinge region; other site 1036743010757 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1036743010758 putative switch regulator; other site 1036743010759 non-specific DNA interactions [nucleotide binding]; other site 1036743010760 DNA binding site [nucleotide binding] 1036743010761 sequence specific DNA binding site [nucleotide binding]; other site 1036743010762 putative cAMP binding site [chemical binding]; other site 1036743010763 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1036743010764 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1036743010765 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1036743010766 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1036743010767 metal-binding site [ion binding] 1036743010768 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1036743010769 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1036743010770 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 1036743010771 FixH; Region: FixH; pfam05751 1036743010772 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1036743010773 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1036743010774 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1036743010775 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1036743010776 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1036743010777 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743010778 ligand binding site [chemical binding]; other site 1036743010779 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1036743010780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743010781 FeS/SAM binding site; other site 1036743010782 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1036743010783 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1036743010784 Cytochrome c; Region: Cytochrom_C; pfam00034 1036743010785 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1036743010786 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1036743010787 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1036743010788 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1036743010789 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1036743010790 Low-spin heme binding site [chemical binding]; other site 1036743010791 Putative water exit pathway; other site 1036743010792 Binuclear center (active site) [active] 1036743010793 Putative proton exit pathway; other site 1036743010794 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1036743010795 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1036743010796 putative RNA binding site [nucleotide binding]; other site 1036743010797 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1036743010798 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1036743010799 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1036743010800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743010801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010802 ATP binding site [chemical binding]; other site 1036743010803 Mg2+ binding site [ion binding]; other site 1036743010804 G-X-G motif; other site 1036743010805 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1036743010806 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1036743010807 Haemolytic domain; Region: Haemolytic; pfam01809 1036743010808 membrane protein insertase; Provisional; Region: PRK01318 1036743010809 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1036743010810 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1036743010811 G1 box; other site 1036743010812 GTP/Mg2+ binding site [chemical binding]; other site 1036743010813 Switch I region; other site 1036743010814 G2 box; other site 1036743010815 G3 box; other site 1036743010816 Switch II region; other site 1036743010817 G4 box; other site 1036743010818 G5 box; other site 1036743010819 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1036743010820 feedback inhibition sensing region; other site 1036743010821 homohexameric interface [polypeptide binding]; other site 1036743010822 nucleotide binding site [chemical binding]; other site 1036743010823 N-acetyl-L-glutamate binding site [chemical binding]; other site 1036743010824 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1036743010825 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1036743010826 dimer interface [polypeptide binding]; other site 1036743010827 active site 1036743010828 catalytic residue [active] 1036743010829 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1036743010830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743010831 motif II; other site 1036743010832 PAS fold; Region: PAS_3; pfam08447 1036743010833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010834 heme pocket [chemical binding]; other site 1036743010835 putative active site [active] 1036743010836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010837 PAS fold; Region: PAS_3; pfam08447 1036743010838 putative active site [active] 1036743010839 heme pocket [chemical binding]; other site 1036743010840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743010841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743010842 metal binding site [ion binding]; metal-binding site 1036743010843 active site 1036743010844 I-site; other site 1036743010845 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743010846 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1036743010847 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1036743010848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743010849 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1036743010850 RmuC family; Region: RmuC; pfam02646 1036743010851 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1036743010852 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1036743010853 active site 1036743010854 catalytic residues [active] 1036743010855 metal binding site [ion binding]; metal-binding site 1036743010856 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1036743010857 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1036743010858 putative active site [active] 1036743010859 substrate binding site [chemical binding]; other site 1036743010860 putative cosubstrate binding site; other site 1036743010861 catalytic site [active] 1036743010862 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1036743010863 substrate binding site [chemical binding]; other site 1036743010864 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1036743010865 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1036743010866 dimerization interface 3.5A [polypeptide binding]; other site 1036743010867 active site 1036743010868 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1036743010869 Protein of unknown function DUF45; Region: DUF45; pfam01863 1036743010870 hypothetical protein; Provisional; Region: PRK05170 1036743010871 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1036743010872 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1036743010873 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1036743010874 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1036743010875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1036743010876 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1036743010877 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1036743010878 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1036743010879 minor groove reading motif; other site 1036743010880 helix-hairpin-helix signature motif; other site 1036743010881 substrate binding pocket [chemical binding]; other site 1036743010882 active site 1036743010883 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1036743010884 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1036743010885 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1036743010886 DNA binding site [nucleotide binding] 1036743010887 active site 1036743010888 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1036743010889 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1036743010890 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1036743010891 conserved cys residue [active] 1036743010892 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1036743010893 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1036743010894 Cu(I) binding site [ion binding]; other site 1036743010895 Family description; Region: DsbD_2; pfam13386 1036743010896 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1036743010897 active site 1036743010898 SAM binding site [chemical binding]; other site 1036743010899 homodimer interface [polypeptide binding]; other site 1036743010900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010901 PAS domain; Region: PAS_9; pfam13426 1036743010902 putative active site [active] 1036743010903 heme pocket [chemical binding]; other site 1036743010904 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743010905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010906 putative active site [active] 1036743010907 heme pocket [chemical binding]; other site 1036743010908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743010909 dimer interface [polypeptide binding]; other site 1036743010910 phosphorylation site [posttranslational modification] 1036743010911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743010912 ATP binding site [chemical binding]; other site 1036743010913 Mg2+ binding site [ion binding]; other site 1036743010914 G-X-G motif; other site 1036743010915 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1036743010916 GTP-binding protein LepA; Provisional; Region: PRK05433 1036743010917 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1036743010918 G1 box; other site 1036743010919 putative GEF interaction site [polypeptide binding]; other site 1036743010920 GTP/Mg2+ binding site [chemical binding]; other site 1036743010921 Switch I region; other site 1036743010922 G2 box; other site 1036743010923 G3 box; other site 1036743010924 Switch II region; other site 1036743010925 G4 box; other site 1036743010926 G5 box; other site 1036743010927 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1036743010928 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1036743010929 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1036743010930 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1036743010931 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1036743010932 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1036743010933 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1036743010934 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1036743010935 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1036743010936 homodimer interface [polypeptide binding]; other site 1036743010937 Walker A motif; other site 1036743010938 ATP binding site [chemical binding]; other site 1036743010939 hydroxycobalamin binding site [chemical binding]; other site 1036743010940 Walker B motif; other site 1036743010941 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1036743010942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743010943 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1036743010944 dimerization interface [polypeptide binding]; other site 1036743010945 substrate binding pocket [chemical binding]; other site 1036743010946 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 1036743010947 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1036743010948 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1036743010949 NAD(P) binding site [chemical binding]; other site 1036743010950 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1036743010951 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 1036743010952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743010953 PAS domain; Region: PAS_9; pfam13426 1036743010954 putative active site [active] 1036743010955 heme pocket [chemical binding]; other site 1036743010956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1036743010957 PAS domain; Region: PAS_9; pfam13426 1036743010958 putative active site [active] 1036743010959 heme pocket [chemical binding]; other site 1036743010960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743010961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743010962 metal binding site [ion binding]; metal-binding site 1036743010963 active site 1036743010964 I-site; other site 1036743010965 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1036743010966 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1036743010967 putative active site [active] 1036743010968 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 1036743010969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743010970 putative ADP-binding pocket [chemical binding]; other site 1036743010971 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1036743010972 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1036743010973 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1036743010974 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1036743010975 putative NAD(P) binding site [chemical binding]; other site 1036743010976 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1036743010977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743010978 binding surface 1036743010979 TPR motif; other site 1036743010980 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1036743010981 putative amphipathic alpha helix; other site 1036743010982 cobyric acid synthase; Provisional; Region: PRK00784 1036743010983 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1036743010984 catalytic triad [active] 1036743010985 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1036743010986 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 1036743010987 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1036743010988 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1036743010989 active site 1036743010990 SAM binding site [chemical binding]; other site 1036743010991 homodimer interface [polypeptide binding]; other site 1036743010992 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1036743010993 ligand binding site [chemical binding]; other site 1036743010994 BioY family; Region: BioY; pfam02632 1036743010995 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 1036743010996 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1036743010997 dimer interface [polypeptide binding]; other site 1036743010998 active site 1036743010999 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1036743011000 UbiA prenyltransferase family; Region: UbiA; pfam01040 1036743011001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1036743011002 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1036743011003 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1036743011004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743011005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743011006 metal binding site [ion binding]; metal-binding site 1036743011007 active site 1036743011008 I-site; other site 1036743011009 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 1036743011010 Transglycosylase; Region: Transgly; pfam00912 1036743011011 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1036743011012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1036743011013 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1036743011014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1036743011015 DNA binding residues [nucleotide binding] 1036743011016 dimerization interface [polypeptide binding]; other site 1036743011017 Autoinducer synthetase; Region: Autoind_synth; cl17404 1036743011018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743011019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743011020 sequence-specific DNA binding site [nucleotide binding]; other site 1036743011021 salt bridge; other site 1036743011022 Predicted transcriptional regulator [Transcription]; Region: COG1959 1036743011023 Transcriptional regulator; Region: Rrf2; pfam02082 1036743011024 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1036743011025 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1036743011026 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1036743011027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743011028 dimer interface [polypeptide binding]; other site 1036743011029 conserved gate region; other site 1036743011030 putative PBP binding loops; other site 1036743011031 ABC-ATPase subunit interface; other site 1036743011032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1036743011033 dimer interface [polypeptide binding]; other site 1036743011034 conserved gate region; other site 1036743011035 putative PBP binding loops; other site 1036743011036 ABC-ATPase subunit interface; other site 1036743011037 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1036743011038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743011039 Walker A/P-loop; other site 1036743011040 ATP binding site [chemical binding]; other site 1036743011041 Q-loop/lid; other site 1036743011042 ABC transporter signature motif; other site 1036743011043 Walker B; other site 1036743011044 D-loop; other site 1036743011045 H-loop/switch region; other site 1036743011046 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1036743011047 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1036743011048 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1036743011049 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1036743011050 substrate binding site [chemical binding]; other site 1036743011051 catalytic Zn binding site [ion binding]; other site 1036743011052 NAD binding site [chemical binding]; other site 1036743011053 structural Zn binding site [ion binding]; other site 1036743011054 dimer interface [polypeptide binding]; other site 1036743011055 S-formylglutathione hydrolase; Region: PLN02442 1036743011056 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1036743011057 6-phosphofructokinase; Provisional; Region: PRK14072 1036743011058 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1036743011059 allosteric effector site; other site 1036743011060 dimerization interface [polypeptide binding]; other site 1036743011061 active site 1036743011062 ADP/pyrophosphate binding site [chemical binding]; other site 1036743011063 fructose-1,6-bisphosphate binding site; other site 1036743011064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1036743011065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1036743011066 active site 1036743011067 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1036743011068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743011069 sequence-specific DNA binding site [nucleotide binding]; other site 1036743011070 salt bridge; other site 1036743011071 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1036743011072 Amidohydrolase; Region: Amidohydro_4; pfam13147 1036743011073 active site 1036743011074 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1036743011075 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1036743011076 Walker A/P-loop; other site 1036743011077 ATP binding site [chemical binding]; other site 1036743011078 Q-loop/lid; other site 1036743011079 ABC transporter signature motif; other site 1036743011080 Walker B; other site 1036743011081 D-loop; other site 1036743011082 H-loop/switch region; other site 1036743011083 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1036743011084 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1036743011085 Walker A/P-loop; other site 1036743011086 ATP binding site [chemical binding]; other site 1036743011087 Q-loop/lid; other site 1036743011088 ABC transporter signature motif; other site 1036743011089 Walker B; other site 1036743011090 D-loop; other site 1036743011091 H-loop/switch region; other site 1036743011092 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1036743011093 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1036743011094 TM-ABC transporter signature motif; other site 1036743011095 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743011096 TM-ABC transporter signature motif; other site 1036743011097 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1036743011098 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1036743011099 ligand binding site [chemical binding]; other site 1036743011100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743011101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743011102 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1036743011103 active site 1036743011104 substrate-binding site [chemical binding]; other site 1036743011105 metal-binding site [ion binding] 1036743011106 GTP binding site [chemical binding]; other site 1036743011107 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1036743011108 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1036743011109 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1036743011110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743011111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743011112 active site 1036743011113 phosphorylation site [posttranslational modification] 1036743011114 intermolecular recognition site; other site 1036743011115 dimerization interface [polypeptide binding]; other site 1036743011116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743011117 DNA binding site [nucleotide binding] 1036743011118 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 1036743011119 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 1036743011120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743011121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743011122 dimerization interface [polypeptide binding]; other site 1036743011123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743011124 dimer interface [polypeptide binding]; other site 1036743011125 phosphorylation site [posttranslational modification] 1036743011126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743011127 ATP binding site [chemical binding]; other site 1036743011128 Mg2+ binding site [ion binding]; other site 1036743011129 G-X-G motif; other site 1036743011130 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1036743011131 active site 1036743011132 dimer interface [polypeptide binding]; other site 1036743011133 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1036743011134 active site 1036743011135 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1036743011136 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1036743011137 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1036743011138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743011139 catalytic residue [active] 1036743011140 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1036743011141 substrate binding site [chemical binding]; other site 1036743011142 active site 1036743011143 catalytic residues [active] 1036743011144 heterodimer interface [polypeptide binding]; other site 1036743011145 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1036743011146 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1036743011147 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1036743011148 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1036743011149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743011150 S-adenosylmethionine binding site [chemical binding]; other site 1036743011151 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1036743011152 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1036743011153 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1036743011154 catalytic residues [active] 1036743011155 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 1036743011156 Part of AAA domain; Region: AAA_19; pfam13245 1036743011157 Family description; Region: UvrD_C_2; pfam13538 1036743011158 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1036743011159 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1036743011160 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1036743011161 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1036743011162 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1036743011163 Substrate binding site; other site 1036743011164 metal-binding site 1036743011165 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1036743011166 Phosphotransferase enzyme family; Region: APH; pfam01636 1036743011167 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1036743011168 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1036743011169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1036743011170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1036743011171 Predicted transcriptional regulators [Transcription]; Region: COG1695 1036743011172 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1036743011173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1036743011174 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1036743011175 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1036743011176 PAS fold; Region: PAS_7; pfam12860 1036743011177 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743011178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743011179 dimer interface [polypeptide binding]; other site 1036743011180 phosphorylation site [posttranslational modification] 1036743011181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743011182 ATP binding site [chemical binding]; other site 1036743011183 Mg2+ binding site [ion binding]; other site 1036743011184 G-X-G motif; other site 1036743011185 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1036743011186 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1036743011187 homotetramer interface [polypeptide binding]; other site 1036743011188 ligand binding site [chemical binding]; other site 1036743011189 catalytic site [active] 1036743011190 NAD binding site [chemical binding]; other site 1036743011191 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1036743011192 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1036743011193 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1036743011194 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1036743011195 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1036743011196 dimerization domain swap beta strand [polypeptide binding]; other site 1036743011197 regulatory protein interface [polypeptide binding]; other site 1036743011198 active site 1036743011199 regulatory phosphorylation site [posttranslational modification]; other site 1036743011200 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1036743011201 active pocket/dimerization site; other site 1036743011202 active site 1036743011203 phosphorylation site [posttranslational modification] 1036743011204 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1036743011205 AAA domain; Region: AAA_18; pfam13238 1036743011206 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1036743011207 Hpr binding site; other site 1036743011208 active site 1036743011209 homohexamer subunit interaction site [polypeptide binding]; other site 1036743011210 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1036743011211 B1 nucleotide binding pocket [chemical binding]; other site 1036743011212 B2 nucleotide binding pocket [chemical binding]; other site 1036743011213 CAS motifs; other site 1036743011214 active site 1036743011215 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1036743011216 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1036743011217 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1036743011218 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1036743011219 Walker A/P-loop; other site 1036743011220 ATP binding site [chemical binding]; other site 1036743011221 Q-loop/lid; other site 1036743011222 ABC transporter signature motif; other site 1036743011223 Walker B; other site 1036743011224 D-loop; other site 1036743011225 H-loop/switch region; other site 1036743011226 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1036743011227 dimer interface [polypeptide binding]; other site 1036743011228 conserved gate region; other site 1036743011229 ABC-ATPase subunit interface; other site 1036743011230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1036743011231 NMT1/THI5 like; Region: NMT1; pfam09084 1036743011232 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1036743011233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743011234 Coenzyme A binding pocket [chemical binding]; other site 1036743011235 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1036743011236 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1036743011237 ligand binding site [chemical binding]; other site 1036743011238 flexible hinge region; other site 1036743011239 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1036743011240 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1036743011241 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1036743011242 N- and C-terminal domain interface [polypeptide binding]; other site 1036743011243 active site 1036743011244 MgATP binding site [chemical binding]; other site 1036743011245 catalytic site [active] 1036743011246 metal binding site [ion binding]; metal-binding site 1036743011247 glycerol binding site [chemical binding]; other site 1036743011248 homotetramer interface [polypeptide binding]; other site 1036743011249 homodimer interface [polypeptide binding]; other site 1036743011250 FBP binding site [chemical binding]; other site 1036743011251 protein IIAGlc interface [polypeptide binding]; other site 1036743011252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743011253 DNA-binding site [nucleotide binding]; DNA binding site 1036743011254 RNA-binding motif; other site 1036743011255 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1036743011256 DNA-binding site [nucleotide binding]; DNA binding site 1036743011257 RNA-binding motif; other site 1036743011258 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743011259 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743011260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743011261 PAS fold; Region: PAS_3; pfam08447 1036743011262 putative active site [active] 1036743011263 heme pocket [chemical binding]; other site 1036743011264 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743011265 dimer interface [polypeptide binding]; other site 1036743011266 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1036743011267 putative CheW interface [polypeptide binding]; other site 1036743011268 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1036743011269 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1036743011270 inhibitor-cofactor binding pocket; inhibition site 1036743011271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743011272 catalytic residue [active] 1036743011273 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1036743011274 Amidinotransferase; Region: Amidinotransf; cl12043 1036743011275 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743011276 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1036743011277 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743011278 recombination protein RecR; Reviewed; Region: recR; PRK00076 1036743011279 RecR protein; Region: RecR; pfam02132 1036743011280 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1036743011281 putative active site [active] 1036743011282 putative metal-binding site [ion binding]; other site 1036743011283 tetramer interface [polypeptide binding]; other site 1036743011284 hypothetical protein; Validated; Region: PRK00153 1036743011285 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1036743011286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743011287 Walker A motif; other site 1036743011288 ATP binding site [chemical binding]; other site 1036743011289 Walker B motif; other site 1036743011290 arginine finger; other site 1036743011291 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1036743011292 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1036743011293 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1036743011294 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1036743011295 heme binding site [chemical binding]; other site 1036743011296 ferroxidase pore; other site 1036743011297 ferroxidase diiron center [ion binding]; other site 1036743011298 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1036743011299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1036743011300 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1036743011301 putative effector binding pocket; other site 1036743011302 dimerization interface [polypeptide binding]; other site 1036743011303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1036743011304 PAS fold; Region: PAS_4; pfam08448 1036743011305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743011306 PAS domain; Region: PAS_9; pfam13426 1036743011307 putative active site [active] 1036743011308 heme pocket [chemical binding]; other site 1036743011309 GAF domain; Region: GAF_3; pfam13492 1036743011310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743011311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743011312 metal binding site [ion binding]; metal-binding site 1036743011313 active site 1036743011314 I-site; other site 1036743011315 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1036743011316 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1036743011317 trimer interface [polypeptide binding]; other site 1036743011318 active site 1036743011319 substrate binding site [chemical binding]; other site 1036743011320 CoA binding site [chemical binding]; other site 1036743011321 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1036743011322 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1036743011323 metal binding site [ion binding]; metal-binding site 1036743011324 dimer interface [polypeptide binding]; other site 1036743011325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1036743011326 MarR family; Region: MarR; pfam01047 1036743011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743011328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1036743011329 putative substrate translocation pore; other site 1036743011330 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1036743011331 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1036743011332 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743011333 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1036743011334 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1036743011335 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1036743011336 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1036743011337 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1036743011338 active site 1036743011339 dimer interface [polypeptide binding]; other site 1036743011340 motif 1; other site 1036743011341 motif 2; other site 1036743011342 motif 3; other site 1036743011343 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1036743011344 anticodon binding site; other site 1036743011345 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1036743011346 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1036743011347 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1036743011348 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1036743011349 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1036743011350 active site 1036743011351 metal binding site [ion binding]; metal-binding site 1036743011352 hexamer interface [polypeptide binding]; other site 1036743011353 Cache domain; Region: Cache_1; pfam02743 1036743011354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743011355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743011356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743011357 dimer interface [polypeptide binding]; other site 1036743011358 phosphorylation site [posttranslational modification] 1036743011359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743011360 ATP binding site [chemical binding]; other site 1036743011361 Mg2+ binding site [ion binding]; other site 1036743011362 G-X-G motif; other site 1036743011363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743011364 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743011365 active site 1036743011366 phosphorylation site [posttranslational modification] 1036743011367 intermolecular recognition site; other site 1036743011368 dimerization interface [polypeptide binding]; other site 1036743011369 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1036743011370 putative binding surface; other site 1036743011371 active site 1036743011372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743011373 Response regulator receiver domain; Region: Response_reg; pfam00072 1036743011374 active site 1036743011375 phosphorylation site [posttranslational modification] 1036743011376 intermolecular recognition site; other site 1036743011377 dimerization interface [polypeptide binding]; other site 1036743011378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743011379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1036743011380 dimerization interface [polypeptide binding]; other site 1036743011381 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1036743011382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743011383 dimer interface [polypeptide binding]; other site 1036743011384 putative CheW interface [polypeptide binding]; other site 1036743011385 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1036743011386 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1036743011387 diiron binding motif [ion binding]; other site 1036743011388 cobalt transport protein CbiM; Validated; Region: PRK06265 1036743011389 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1036743011390 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1036743011391 Cytochrome C' Region: Cytochrom_C_2; cl01610 1036743011392 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1036743011393 dimer interface [polypeptide binding]; other site 1036743011394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1036743011395 ligand binding site [chemical binding]; other site 1036743011396 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1036743011397 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1036743011398 acyl-activating enzyme (AAE) consensus motif; other site 1036743011399 AMP binding site [chemical binding]; other site 1036743011400 active site 1036743011401 CoA binding site [chemical binding]; other site 1036743011402 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1036743011403 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1036743011404 Walker A/P-loop; other site 1036743011405 ATP binding site [chemical binding]; other site 1036743011406 Q-loop/lid; other site 1036743011407 ABC transporter signature motif; other site 1036743011408 Walker B; other site 1036743011409 D-loop; other site 1036743011410 H-loop/switch region; other site 1036743011411 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1036743011412 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1036743011413 putative ligand binding site [chemical binding]; other site 1036743011414 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743011415 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1036743011416 TM-ABC transporter signature motif; other site 1036743011417 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743011418 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743011419 TM-ABC transporter signature motif; other site 1036743011420 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1036743011421 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1036743011422 acyl-activating enzyme (AAE) consensus motif; other site 1036743011423 putative AMP binding site [chemical binding]; other site 1036743011424 putative active site [active] 1036743011425 putative CoA binding site [chemical binding]; other site 1036743011426 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1036743011427 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1036743011428 Walker A/P-loop; other site 1036743011429 ATP binding site [chemical binding]; other site 1036743011430 Q-loop/lid; other site 1036743011431 ABC transporter signature motif; other site 1036743011432 Walker B; other site 1036743011433 D-loop; other site 1036743011434 H-loop/switch region; other site 1036743011435 aconitate hydratase; Validated; Region: PRK09277 1036743011436 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1036743011437 substrate binding site [chemical binding]; other site 1036743011438 ligand binding site [chemical binding]; other site 1036743011439 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1036743011440 substrate binding site [chemical binding]; other site 1036743011441 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1036743011442 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1036743011443 catalytic triad [active] 1036743011444 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743011445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743011446 dimer interface [polypeptide binding]; other site 1036743011447 putative CheW interface [polypeptide binding]; other site 1036743011448 DNA polymerase I; Provisional; Region: PRK05755 1036743011449 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1036743011450 active site 1036743011451 metal binding site 1 [ion binding]; metal-binding site 1036743011452 putative 5' ssDNA interaction site; other site 1036743011453 metal binding site 3; metal-binding site 1036743011454 metal binding site 2 [ion binding]; metal-binding site 1036743011455 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1036743011456 putative DNA binding site [nucleotide binding]; other site 1036743011457 putative metal binding site [ion binding]; other site 1036743011458 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1036743011459 active site 1036743011460 catalytic site [active] 1036743011461 substrate binding site [chemical binding]; other site 1036743011462 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1036743011463 active site 1036743011464 DNA binding site [nucleotide binding] 1036743011465 catalytic site [active] 1036743011466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743011467 PAS domain; Region: PAS_9; pfam13426 1036743011468 putative active site [active] 1036743011469 heme pocket [chemical binding]; other site 1036743011470 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1036743011471 LytTr DNA-binding domain; Region: LytTR; smart00850 1036743011472 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1036743011473 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1036743011474 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1036743011475 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1036743011476 MarR family; Region: MarR_2; cl17246 1036743011477 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1036743011478 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1036743011479 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1036743011480 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1036743011481 23S rRNA binding site [nucleotide binding]; other site 1036743011482 L21 binding site [polypeptide binding]; other site 1036743011483 L13 binding site [polypeptide binding]; other site 1036743011484 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1036743011485 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1036743011486 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1036743011487 dimer interface [polypeptide binding]; other site 1036743011488 motif 1; other site 1036743011489 active site 1036743011490 motif 2; other site 1036743011491 motif 3; other site 1036743011492 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1036743011493 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1036743011494 putative tRNA-binding site [nucleotide binding]; other site 1036743011495 B3/4 domain; Region: B3_4; pfam03483 1036743011496 tRNA synthetase B5 domain; Region: B5; smart00874 1036743011497 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1036743011498 dimer interface [polypeptide binding]; other site 1036743011499 motif 1; other site 1036743011500 motif 3; other site 1036743011501 motif 2; other site 1036743011502 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1036743011503 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1036743011504 YGGT family; Region: YGGT; pfam02325 1036743011505 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743011506 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743011507 TM-ABC transporter signature motif; other site 1036743011508 DNA polymerase IV; Provisional; Region: PRK02794 1036743011509 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1036743011510 active site 1036743011511 DNA binding site [nucleotide binding] 1036743011512 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1036743011513 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1036743011514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1036743011515 Ligand Binding Site [chemical binding]; other site 1036743011516 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 1036743011517 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 1036743011518 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1036743011519 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1036743011520 active site 1036743011521 HIGH motif; other site 1036743011522 dimer interface [polypeptide binding]; other site 1036743011523 KMSKS motif; other site 1036743011524 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1036743011525 putative FMN binding site [chemical binding]; other site 1036743011526 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1036743011527 integral membrane protein MviN; Region: mviN; TIGR01695 1036743011528 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1036743011529 PII uridylyl-transferase; Provisional; Region: PRK05092 1036743011530 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1036743011531 metal binding triad; other site 1036743011532 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1036743011533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1036743011534 Zn2+ binding site [ion binding]; other site 1036743011535 Mg2+ binding site [ion binding]; other site 1036743011536 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1036743011537 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1036743011538 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1036743011539 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1036743011540 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1036743011541 MutS domain I; Region: MutS_I; pfam01624 1036743011542 MutS domain II; Region: MutS_II; pfam05188 1036743011543 MutS domain III; Region: MutS_III; pfam05192 1036743011544 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1036743011545 Walker A/P-loop; other site 1036743011546 ATP binding site [chemical binding]; other site 1036743011547 Q-loop/lid; other site 1036743011548 ABC transporter signature motif; other site 1036743011549 Walker B; other site 1036743011550 D-loop; other site 1036743011551 H-loop/switch region; other site 1036743011552 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1036743011553 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1036743011554 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1036743011555 putative NAD(P) binding site [chemical binding]; other site 1036743011556 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1036743011557 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1036743011558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1036743011559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743011560 dimer interface [polypeptide binding]; other site 1036743011561 phosphorylation site [posttranslational modification] 1036743011562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743011563 ATP binding site [chemical binding]; other site 1036743011564 Mg2+ binding site [ion binding]; other site 1036743011565 G-X-G motif; other site 1036743011566 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1036743011567 PhoU domain; Region: PhoU; pfam01895 1036743011568 PhoU domain; Region: PhoU; pfam01895 1036743011569 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1036743011570 anthranilate synthase; Provisional; Region: PRK13566 1036743011571 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1036743011572 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1036743011573 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1036743011574 glutamine binding [chemical binding]; other site 1036743011575 catalytic triad [active] 1036743011576 Cysteine-rich small domain; Region: zf-like; cl00946 1036743011577 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 1036743011578 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1036743011579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743011580 FeS/SAM binding site; other site 1036743011581 cobyric acid synthase; Provisional; Region: PRK00784 1036743011582 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743011583 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1036743011584 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1036743011585 catalytic triad [active] 1036743011586 cobyric acid synthase; Provisional; Region: PRK00784 1036743011587 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1036743011588 catalytic triad [active] 1036743011589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1036743011590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1036743011591 active site 1036743011592 catalytic tetrad [active] 1036743011593 CcdB protein; Region: CcdB; cl03380 1036743011594 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1036743011595 chaperone protein DnaJ; Provisional; Region: PRK10767 1036743011596 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1036743011597 HSP70 interaction site [polypeptide binding]; other site 1036743011598 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1036743011599 substrate binding site [polypeptide binding]; other site 1036743011600 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1036743011601 Zn binding sites [ion binding]; other site 1036743011602 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1036743011603 dimer interface [polypeptide binding]; other site 1036743011604 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1036743011605 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1036743011606 nucleotide binding site [chemical binding]; other site 1036743011607 NEF interaction site [polypeptide binding]; other site 1036743011608 SBD interface [polypeptide binding]; other site 1036743011609 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 1036743011610 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1036743011611 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1036743011612 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1036743011613 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1036743011614 HSP70 interaction site [polypeptide binding]; other site 1036743011615 PAS domain; Region: PAS_9; pfam13426 1036743011616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743011617 putative active site [active] 1036743011618 PAS fold; Region: PAS_3; pfam08447 1036743011619 PAS domain S-box; Region: sensory_box; TIGR00229 1036743011620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743011621 putative active site [active] 1036743011622 heme pocket [chemical binding]; other site 1036743011623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743011624 PAS fold; Region: PAS_3; pfam08447 1036743011625 putative active site [active] 1036743011626 heme pocket [chemical binding]; other site 1036743011627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1036743011628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1036743011629 metal binding site [ion binding]; metal-binding site 1036743011630 active site 1036743011631 I-site; other site 1036743011632 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1036743011633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1036743011634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1036743011635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743011636 Walker A/P-loop; other site 1036743011637 ATP binding site [chemical binding]; other site 1036743011638 Q-loop/lid; other site 1036743011639 ABC transporter signature motif; other site 1036743011640 Walker B; other site 1036743011641 D-loop; other site 1036743011642 H-loop/switch region; other site 1036743011643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1036743011644 dimerization interface [polypeptide binding]; other site 1036743011645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1036743011646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743011647 dimer interface [polypeptide binding]; other site 1036743011648 putative CheW interface [polypeptide binding]; other site 1036743011649 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1036743011650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1036743011651 active site 1036743011652 motif I; other site 1036743011653 motif II; other site 1036743011654 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1036743011655 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 1036743011656 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1036743011657 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1036743011658 active site 1036743011659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 1036743011660 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1036743011661 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1036743011662 domain interfaces; other site 1036743011663 active site 1036743011664 UGMP family protein; Validated; Region: PRK09604 1036743011665 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1036743011666 Domain of unknown function DUF29; Region: DUF29; pfam01724 1036743011667 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1036743011668 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1036743011669 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1036743011670 YciI-like protein; Reviewed; Region: PRK12863 1036743011671 EVE domain; Region: EVE; pfam01878 1036743011672 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1036743011673 iron-sulfur cluster [ion binding]; other site 1036743011674 [2Fe-2S] cluster binding site [ion binding]; other site 1036743011675 acetyl-CoA synthetase; Provisional; Region: PRK00174 1036743011676 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1036743011677 active site 1036743011678 CoA binding site [chemical binding]; other site 1036743011679 acyl-activating enzyme (AAE) consensus motif; other site 1036743011680 AMP binding site [chemical binding]; other site 1036743011681 acetate binding site [chemical binding]; other site 1036743011682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1036743011683 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1036743011684 putative NAD(P) binding site [chemical binding]; other site 1036743011685 active site 1036743011686 putative substrate binding site [chemical binding]; other site 1036743011687 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1036743011688 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1036743011689 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1036743011690 heat shock protein HtpX; Provisional; Region: PRK01345 1036743011691 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1036743011692 EamA-like transporter family; Region: EamA; pfam00892 1036743011693 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1036743011694 aromatic arch; other site 1036743011695 DCoH dimer interaction site [polypeptide binding]; other site 1036743011696 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1036743011697 DCoH tetramer interaction site [polypeptide binding]; other site 1036743011698 substrate binding site [chemical binding]; other site 1036743011699 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1036743011700 ATP-dependent protease Lon; Provisional; Region: PRK13765 1036743011701 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1036743011702 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1036743011703 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 1036743011704 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1036743011705 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1036743011706 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1036743011707 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1036743011708 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1036743011709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743011710 Walker A motif; other site 1036743011711 ATP binding site [chemical binding]; other site 1036743011712 Walker B motif; other site 1036743011713 arginine finger; other site 1036743011714 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1036743011715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743011716 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1036743011717 nucleotide binding site/active site [active] 1036743011718 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1036743011719 metal binding site [ion binding]; metal-binding site 1036743011720 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1036743011721 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1036743011722 substrate binding site [chemical binding]; other site 1036743011723 glutamase interaction surface [polypeptide binding]; other site 1036743011724 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1036743011725 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1036743011726 catalytic residues [active] 1036743011727 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1036743011728 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1036743011729 putative active site [active] 1036743011730 oxyanion strand; other site 1036743011731 catalytic triad [active] 1036743011732 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1036743011733 putative active site pocket [active] 1036743011734 4-fold oligomerization interface [polypeptide binding]; other site 1036743011735 metal binding residues [ion binding]; metal-binding site 1036743011736 3-fold/trimer interface [polypeptide binding]; other site 1036743011737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743011738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743011739 sequence-specific DNA binding site [nucleotide binding]; other site 1036743011740 salt bridge; other site 1036743011741 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1036743011742 active site 1036743011743 HslU subunit interaction site [polypeptide binding]; other site 1036743011744 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1036743011745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1036743011746 Walker A motif; other site 1036743011747 ATP binding site [chemical binding]; other site 1036743011748 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1036743011749 Walker B motif; other site 1036743011750 arginine finger; other site 1036743011751 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1036743011752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743011753 Helix-turn-helix domain; Region: HTH_19; pfam12844 1036743011754 sequence-specific DNA binding site [nucleotide binding]; other site 1036743011755 salt bridge; other site 1036743011756 Smr domain; Region: Smr; pfam01713 1036743011757 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1036743011758 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1036743011759 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1036743011760 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1036743011761 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1036743011762 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1036743011763 Cysteine-rich domain; Region: CCG; pfam02754 1036743011764 Cysteine-rich domain; Region: CCG; pfam02754 1036743011765 MltA specific insert domain; Region: MltA; smart00925 1036743011766 3D domain; Region: 3D; pfam06725 1036743011767 Tim44-like domain; Region: Tim44; pfam04280 1036743011768 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1036743011769 preprotein translocase subunit SecB; Validated; Region: PRK05751 1036743011770 SecA binding site; other site 1036743011771 Preprotein binding site; other site 1036743011772 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1036743011773 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1036743011774 active site 1036743011775 catalytic site [active] 1036743011776 substrate binding site [chemical binding]; other site 1036743011777 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1036743011778 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1036743011779 CoA-binding site [chemical binding]; other site 1036743011780 ATP-binding [chemical binding]; other site 1036743011781 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1036743011782 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1036743011783 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1036743011784 shikimate binding site; other site 1036743011785 NAD(P) binding site [chemical binding]; other site 1036743011786 Maf-like protein; Region: Maf; pfam02545 1036743011787 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1036743011788 active site 1036743011789 dimer interface [polypeptide binding]; other site 1036743011790 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1036743011791 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1036743011792 substrate binding site [chemical binding]; other site 1036743011793 active site 1036743011794 Ferrochelatase; Region: Ferrochelatase; pfam00762 1036743011795 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1036743011796 C-terminal domain interface [polypeptide binding]; other site 1036743011797 active site 1036743011798 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1036743011799 active site 1036743011800 N-terminal domain interface [polypeptide binding]; other site 1036743011801 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1036743011802 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1036743011803 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1036743011804 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1036743011805 RNA binding site [nucleotide binding]; other site 1036743011806 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1036743011807 multimer interface [polypeptide binding]; other site 1036743011808 Walker A motif; other site 1036743011809 ATP binding site [chemical binding]; other site 1036743011810 Walker B motif; other site 1036743011811 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1036743011812 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1036743011813 NADP binding site [chemical binding]; other site 1036743011814 dimer interface [polypeptide binding]; other site 1036743011815 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1036743011816 DNA binding site [nucleotide binding] 1036743011817 active site 1036743011818 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1036743011819 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1036743011820 catalytic residues [active] 1036743011821 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1036743011822 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1036743011823 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1036743011824 G1 box; other site 1036743011825 GTP/Mg2+ binding site [chemical binding]; other site 1036743011826 Switch I region; other site 1036743011827 G2 box; other site 1036743011828 Switch II region; other site 1036743011829 G3 box; other site 1036743011830 G4 box; other site 1036743011831 G5 box; other site 1036743011832 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1036743011833 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1036743011834 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1036743011835 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1036743011836 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1036743011837 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1036743011838 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1036743011839 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743011840 P-loop; other site 1036743011841 Magnesium ion binding site [ion binding]; other site 1036743011842 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1036743011843 Magnesium ion binding site [ion binding]; other site 1036743011844 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1036743011845 ParB-like nuclease domain; Region: ParB; smart00470 1036743011846 KorB domain; Region: KorB; pfam08535 1036743011847 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1036743011848 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1036743011849 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1036743011850 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1036743011851 HIGH motif; other site 1036743011852 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1036743011853 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1036743011854 active site 1036743011855 KMSKS motif; other site 1036743011856 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1036743011857 tRNA binding surface [nucleotide binding]; other site 1036743011858 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 1036743011859 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1036743011860 thiamine phosphate binding site [chemical binding]; other site 1036743011861 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1036743011862 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1036743011863 catalytic residue [active] 1036743011864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1036743011865 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1036743011866 dimerization interface [polypeptide binding]; other site 1036743011867 active site 1036743011868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1036743011869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1036743011870 active site 1036743011871 phosphorylation site [posttranslational modification] 1036743011872 intermolecular recognition site; other site 1036743011873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1036743011874 DNA binding site [nucleotide binding] 1036743011875 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1036743011876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743011877 FeS/SAM binding site; other site 1036743011878 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1036743011879 active site 1036743011880 dimerization interface [polypeptide binding]; other site 1036743011881 ribonuclease PH; Reviewed; Region: rph; PRK00173 1036743011882 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1036743011883 hexamer interface [polypeptide binding]; other site 1036743011884 active site 1036743011885 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1036743011886 GrpE; Region: GrpE; pfam01025 1036743011887 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1036743011888 dimer interface [polypeptide binding]; other site 1036743011889 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1036743011890 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1036743011891 putative uracil binding site [chemical binding]; other site 1036743011892 putative active site [active] 1036743011893 NAD-dependent deacetylase; Provisional; Region: PRK00481 1036743011894 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1036743011895 NAD+ binding site [chemical binding]; other site 1036743011896 substrate binding site [chemical binding]; other site 1036743011897 Zn binding site [ion binding]; other site 1036743011898 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1036743011899 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1036743011900 active site 1036743011901 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1036743011902 Phosphotransferase enzyme family; Region: APH; pfam01636 1036743011903 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1036743011904 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1036743011905 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1036743011906 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1036743011907 active site 1036743011908 catalytic triad [active] 1036743011909 oxyanion hole [active] 1036743011910 switch loop; other site 1036743011911 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1036743011912 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1036743011913 Walker A/P-loop; other site 1036743011914 ATP binding site [chemical binding]; other site 1036743011915 Q-loop/lid; other site 1036743011916 ABC transporter signature motif; other site 1036743011917 Walker B; other site 1036743011918 D-loop; other site 1036743011919 H-loop/switch region; other site 1036743011920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1036743011921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743011922 S-adenosylmethionine binding site [chemical binding]; other site 1036743011923 FtsX-like permease family; Region: FtsX; pfam02687 1036743011924 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1036743011925 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1036743011926 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1036743011927 purine monophosphate binding site [chemical binding]; other site 1036743011928 dimer interface [polypeptide binding]; other site 1036743011929 putative catalytic residues [active] 1036743011930 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1036743011931 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1036743011932 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1036743011933 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1036743011934 NAD(P) binding site [chemical binding]; other site 1036743011935 homodimer interface [polypeptide binding]; other site 1036743011936 substrate binding site [chemical binding]; other site 1036743011937 active site 1036743011938 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1036743011939 Mg++ binding site [ion binding]; other site 1036743011940 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1036743011941 putative catalytic motif [active] 1036743011942 putative substrate binding site [chemical binding]; other site 1036743011943 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1036743011944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1036743011945 putative ADP-binding pocket [chemical binding]; other site 1036743011946 NusB family; Region: NusB; pfam01029 1036743011947 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1036743011948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743011949 S-adenosylmethionine binding site [chemical binding]; other site 1036743011950 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1036743011951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1036743011952 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1036743011953 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1036743011954 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1036743011955 Walker A/P-loop; other site 1036743011956 ATP binding site [chemical binding]; other site 1036743011957 Q-loop/lid; other site 1036743011958 ABC transporter signature motif; other site 1036743011959 Walker B; other site 1036743011960 D-loop; other site 1036743011961 H-loop/switch region; other site 1036743011962 CHASE3 domain; Region: CHASE3; pfam05227 1036743011963 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1036743011964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1036743011965 dimer interface [polypeptide binding]; other site 1036743011966 putative CheW interface [polypeptide binding]; other site 1036743011967 short chain dehydrogenase; Provisional; Region: PRK06701 1036743011968 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1036743011969 NAD binding site [chemical binding]; other site 1036743011970 metal binding site [ion binding]; metal-binding site 1036743011971 active site 1036743011972 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1036743011973 putative deacylase active site [active] 1036743011974 hypothetical protein; Provisional; Region: PRK05208 1036743011975 putative cation:proton antiport protein; Provisional; Region: PRK10669 1036743011976 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1036743011977 TrkA-N domain; Region: TrkA_N; pfam02254 1036743011978 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1036743011979 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1036743011980 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1036743011981 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1036743011982 Protein export membrane protein; Region: SecD_SecF; pfam02355 1036743011983 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1036743011984 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1036743011985 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1036743011986 putative C-terminal domain interface [polypeptide binding]; other site 1036743011987 putative GSH binding site (G-site) [chemical binding]; other site 1036743011988 putative dimer interface [polypeptide binding]; other site 1036743011989 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1036743011990 putative N-terminal domain interface [polypeptide binding]; other site 1036743011991 putative dimer interface [polypeptide binding]; other site 1036743011992 putative substrate binding pocket (H-site) [chemical binding]; other site 1036743011993 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1036743011994 DctM-like transporters; Region: DctM; pfam06808 1036743011995 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1036743011996 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1036743011997 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1036743011998 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1036743011999 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1036743012000 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1036743012001 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1036743012002 YceI-like domain; Region: YceI; pfam04264 1036743012003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1036743012004 binding surface 1036743012005 TPR repeat; Region: TPR_11; pfam13414 1036743012006 TPR motif; other site 1036743012007 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1036743012008 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743012009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1036743012010 putative DNA binding site [nucleotide binding]; other site 1036743012011 putative Zn2+ binding site [ion binding]; other site 1036743012012 AsnC family; Region: AsnC_trans_reg; pfam01037 1036743012013 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1036743012014 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1036743012015 hexamer interface [polypeptide binding]; other site 1036743012016 ligand binding site [chemical binding]; other site 1036743012017 putative active site [active] 1036743012018 NAD(P) binding site [chemical binding]; other site 1036743012019 Cobalt transport protein; Region: CbiQ; cl00463 1036743012020 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1036743012021 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1036743012022 Walker A/P-loop; other site 1036743012023 ATP binding site [chemical binding]; other site 1036743012024 Q-loop/lid; other site 1036743012025 ABC transporter signature motif; other site 1036743012026 Walker B; other site 1036743012027 D-loop; other site 1036743012028 H-loop/switch region; other site 1036743012029 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1036743012030 active site 2 [active] 1036743012031 active site 1 [active] 1036743012032 glutathione synthetase; Provisional; Region: PRK05246 1036743012033 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1036743012034 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1036743012035 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1036743012036 BON domain; Region: BON; pfam04972 1036743012037 hypothetical protein; Reviewed; Region: PRK12497 1036743012038 Predicted methyltransferases [General function prediction only]; Region: COG0313 1036743012039 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1036743012040 putative SAM binding site [chemical binding]; other site 1036743012041 putative homodimer interface [polypeptide binding]; other site 1036743012042 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1036743012043 putative ligand binding site [chemical binding]; other site 1036743012044 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1036743012045 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1036743012046 acyl-activating enzyme (AAE) consensus motif; other site 1036743012047 putative AMP binding site [chemical binding]; other site 1036743012048 putative active site [active] 1036743012049 putative CoA binding site [chemical binding]; other site 1036743012050 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1036743012051 putative catalytic site [active] 1036743012052 putative metal binding site [ion binding]; other site 1036743012053 putative phosphate binding site [ion binding]; other site 1036743012054 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1036743012055 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1036743012056 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1036743012057 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1036743012058 multidrug efflux protein; Reviewed; Region: PRK09579 1036743012059 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1036743012060 HlyD family secretion protein; Region: HlyD_3; pfam13437 1036743012061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1036743012062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1036743012063 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1036743012064 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1036743012065 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1036743012066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1036743012067 ABC-ATPase subunit interface; other site 1036743012068 dimer interface [polypeptide binding]; other site 1036743012069 putative PBP binding regions; other site 1036743012070 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1036743012071 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1036743012072 metal binding site [ion binding]; metal-binding site 1036743012073 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1036743012074 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1036743012075 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1036743012076 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1036743012077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743012078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743012079 homodimer interface [polypeptide binding]; other site 1036743012080 catalytic residue [active] 1036743012081 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1036743012082 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1036743012083 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1036743012084 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1036743012085 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1036743012086 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1036743012087 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1036743012088 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1036743012089 LysE type translocator; Region: LysE; cl00565 1036743012090 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1036743012091 Chain length determinant protein; Region: Wzz; cl15801 1036743012092 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1036743012093 AAA domain; Region: AAA_31; pfam13614 1036743012094 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1036743012095 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1036743012096 SLBB domain; Region: SLBB; pfam10531 1036743012097 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1036743012098 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1036743012099 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1036743012100 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1036743012101 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1036743012102 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 1036743012103 active site 1036743012104 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1036743012105 CHAP domain; Region: CHAP; pfam05257 1036743012106 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1036743012107 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1036743012108 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1036743012109 Walker A/P-loop; other site 1036743012110 ATP binding site [chemical binding]; other site 1036743012111 Q-loop/lid; other site 1036743012112 ABC transporter signature motif; other site 1036743012113 Walker B; other site 1036743012114 D-loop; other site 1036743012115 H-loop/switch region; other site 1036743012116 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1036743012117 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1036743012118 Walker A/P-loop; other site 1036743012119 ATP binding site [chemical binding]; other site 1036743012120 Q-loop/lid; other site 1036743012121 ABC transporter signature motif; other site 1036743012122 Walker B; other site 1036743012123 D-loop; other site 1036743012124 H-loop/switch region; other site 1036743012125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1036743012126 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1036743012127 TM-ABC transporter signature motif; other site 1036743012128 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1036743012129 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1036743012130 TM-ABC transporter signature motif; other site 1036743012131 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1036743012132 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1036743012133 putative ligand binding site [chemical binding]; other site 1036743012134 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1036743012135 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 1036743012136 active site 1036743012137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743012138 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1036743012139 DNA-binding site [nucleotide binding]; DNA binding site 1036743012140 FCD domain; Region: FCD; pfam07729 1036743012141 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1036743012142 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1036743012143 active site 1036743012144 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1036743012145 active site 1036743012146 HIGH motif; other site 1036743012147 nucleotide binding site [chemical binding]; other site 1036743012148 active site 1036743012149 KMSKS motif; other site 1036743012150 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1036743012151 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1036743012152 RES domain; Region: RES; pfam08808 1036743012153 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1036743012154 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1036743012155 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1036743012156 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1036743012157 active site 1036743012158 DNA binding site [nucleotide binding] 1036743012159 Int/Topo IB signature motif; other site 1036743012160 shikimate kinase; Provisional; Region: PRK13946 1036743012161 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1036743012162 ADP binding site [chemical binding]; other site 1036743012163 magnesium binding site [ion binding]; other site 1036743012164 putative shikimate binding site; other site 1036743012165 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1036743012166 active site 1036743012167 dimer interface [polypeptide binding]; other site 1036743012168 metal binding site [ion binding]; metal-binding site 1036743012169 potential frameshift: common BLAST hit: gi|384261786|ref|YP_005416972.1| Mg2+ and Co2+ transporter CorB 1036743012170 FOG: CBS domain [General function prediction only]; Region: COG0517 1036743012171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1036743012172 Transporter associated domain; Region: CorC_HlyC; smart01091 1036743012173 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1036743012174 FOG: CBS domain [General function prediction only]; Region: COG0517 1036743012175 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1036743012176 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1036743012177 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1036743012178 5S rRNA interface [nucleotide binding]; other site 1036743012179 CTC domain interface [polypeptide binding]; other site 1036743012180 L16 interface [polypeptide binding]; other site 1036743012181 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1036743012182 putative active site [active] 1036743012183 catalytic residue [active] 1036743012184 GTP-binding protein YchF; Reviewed; Region: PRK09601 1036743012185 YchF GTPase; Region: YchF; cd01900 1036743012186 G1 box; other site 1036743012187 GTP/Mg2+ binding site [chemical binding]; other site 1036743012188 Switch I region; other site 1036743012189 G2 box; other site 1036743012190 Switch II region; other site 1036743012191 G3 box; other site 1036743012192 G4 box; other site 1036743012193 G5 box; other site 1036743012194 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1036743012195 Predicted ATPase [General function prediction only]; Region: COG4637 1036743012196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1036743012197 Walker A/P-loop; other site 1036743012198 ATP binding site [chemical binding]; other site 1036743012199 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1036743012200 argininosuccinate synthase; Provisional; Region: PRK13820 1036743012201 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1036743012202 ANP binding site [chemical binding]; other site 1036743012203 Substrate Binding Site II [chemical binding]; other site 1036743012204 Substrate Binding Site I [chemical binding]; other site 1036743012205 Domain of unknown function DUF302; Region: DUF302; pfam03625 1036743012206 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 1036743012207 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1036743012208 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1036743012209 putative dimer interface [polypeptide binding]; other site 1036743012210 PAS fold; Region: PAS_4; pfam08448 1036743012211 PAS domain S-box; Region: sensory_box; TIGR00229 1036743012212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1036743012213 putative active site [active] 1036743012214 heme pocket [chemical binding]; other site 1036743012215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1036743012216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1036743012217 dimer interface [polypeptide binding]; other site 1036743012218 phosphorylation site [posttranslational modification] 1036743012219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1036743012220 ATP binding site [chemical binding]; other site 1036743012221 Mg2+ binding site [ion binding]; other site 1036743012222 G-X-G motif; other site 1036743012223 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1036743012224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1036743012225 active site 1036743012226 phosphorylation site [posttranslational modification] 1036743012227 intermolecular recognition site; other site 1036743012228 dimerization interface [polypeptide binding]; other site 1036743012229 Helix-turn-helix domain; Region: HTH_17; pfam12728 1036743012230 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1036743012231 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1036743012232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1036743012233 DNA-binding site [nucleotide binding]; DNA binding site 1036743012234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1036743012235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743012236 homodimer interface [polypeptide binding]; other site 1036743012237 catalytic residue [active] 1036743012238 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1036743012239 putative chaperone; Provisional; Region: PRK11678 1036743012240 nucleotide binding site [chemical binding]; other site 1036743012241 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1036743012242 SBD interface [polypeptide binding]; other site 1036743012243 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1036743012244 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1036743012245 Glycoprotease family; Region: Peptidase_M22; pfam00814 1036743012246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1036743012247 Coenzyme A binding pocket [chemical binding]; other site 1036743012248 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1036743012249 CPxP motif; other site 1036743012250 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1036743012251 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1036743012252 metal binding site 2 [ion binding]; metal-binding site 1036743012253 putative DNA binding helix; other site 1036743012254 metal binding site 1 [ion binding]; metal-binding site 1036743012255 dimer interface [polypeptide binding]; other site 1036743012256 structural Zn2+ binding site [ion binding]; other site 1036743012257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1036743012258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1036743012259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1036743012260 putative acyl-acceptor binding pocket; other site 1036743012261 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1036743012262 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1036743012263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1036743012264 FeS/SAM binding site; other site 1036743012265 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1036743012266 PhoH-like protein; Region: PhoH; pfam02562 1036743012267 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1036743012268 FOG: CBS domain [General function prediction only]; Region: COG0517 1036743012269 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1036743012270 Transporter associated domain; Region: CorC_HlyC; smart01091 1036743012271 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1036743012272 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1036743012273 putative active site [active] 1036743012274 catalytic triad [active] 1036743012275 putative dimer interface [polypeptide binding]; other site 1036743012276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1036743012277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1036743012278 non-specific DNA binding site [nucleotide binding]; other site 1036743012279 salt bridge; other site 1036743012280 sequence-specific DNA binding site [nucleotide binding]; other site 1036743012281 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1036743012282 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1036743012283 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1036743012284 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1036743012285 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1036743012286 Sm and related proteins; Region: Sm_like; cl00259 1036743012287 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1036743012288 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1036743012289 putative oligomer interface [polypeptide binding]; other site 1036743012290 putative RNA binding site [nucleotide binding]; other site 1036743012291 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1036743012292 NusA N-terminal domain; Region: NusA_N; pfam08529 1036743012293 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1036743012294 RNA binding site [nucleotide binding]; other site 1036743012295 homodimer interface [polypeptide binding]; other site 1036743012296 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1036743012297 G-X-X-G motif; other site 1036743012298 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1036743012299 G-X-X-G motif; other site 1036743012300 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1036743012301 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1036743012302 hypothetical protein; Provisional; Region: PRK09190 1036743012303 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1036743012304 putative RNA binding cleft [nucleotide binding]; other site 1036743012305 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1036743012306 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1036743012307 translation initiation factor IF-2; Region: IF-2; TIGR00487 1036743012308 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1036743012309 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1036743012310 G1 box; other site 1036743012311 putative GEF interaction site [polypeptide binding]; other site 1036743012312 GTP/Mg2+ binding site [chemical binding]; other site 1036743012313 Switch I region; other site 1036743012314 G2 box; other site 1036743012315 G3 box; other site 1036743012316 Switch II region; other site 1036743012317 G4 box; other site 1036743012318 G5 box; other site 1036743012319 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1036743012320 Translation-initiation factor 2; Region: IF-2; pfam11987 1036743012321 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1036743012322 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1036743012323 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1036743012324 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1036743012325 RNA binding site [nucleotide binding]; other site 1036743012326 active site 1036743012327 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1036743012328 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1036743012329 16S/18S rRNA binding site [nucleotide binding]; other site 1036743012330 S13e-L30e interaction site [polypeptide binding]; other site 1036743012331 25S rRNA binding site [nucleotide binding]; other site 1036743012332 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1036743012333 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1036743012334 RNase E interface [polypeptide binding]; other site 1036743012335 trimer interface [polypeptide binding]; other site 1036743012336 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1036743012337 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1036743012338 RNase E interface [polypeptide binding]; other site 1036743012339 trimer interface [polypeptide binding]; other site 1036743012340 active site 1036743012341 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1036743012342 putative nucleic acid binding region [nucleotide binding]; other site 1036743012343 G-X-X-G motif; other site 1036743012344 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1036743012345 RNA binding site [nucleotide binding]; other site 1036743012346 domain interface; other site 1036743012347 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1036743012348 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1036743012349 active site 1036743012350 catalytic site [active] 1036743012351 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1036743012352 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1036743012353 FMN binding site [chemical binding]; other site 1036743012354 substrate binding site [chemical binding]; other site 1036743012355 putative catalytic residue [active] 1036743012356 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1036743012357 metal binding site 2 [ion binding]; metal-binding site 1036743012358 putative DNA binding helix; other site 1036743012359 metal binding site 1 [ion binding]; metal-binding site 1036743012360 dimer interface [polypeptide binding]; other site 1036743012361 structural Zn2+ binding site [ion binding]; other site 1036743012362 Bacterial SH3 domain; Region: SH3_4; pfam06347 1036743012363 Bacterial SH3 domain; Region: SH3_4; pfam06347 1036743012364 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1036743012365 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1036743012366 dimerization interface [polypeptide binding]; other site 1036743012367 ligand binding site [chemical binding]; other site 1036743012368 NADP binding site [chemical binding]; other site 1036743012369 catalytic site [active] 1036743012370 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1036743012371 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1036743012372 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1036743012373 ATP binding site [chemical binding]; other site 1036743012374 substrate interface [chemical binding]; other site 1036743012375 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1036743012376 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1036743012377 dimer interface [polypeptide binding]; other site 1036743012378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1036743012379 catalytic residue [active] 1036743012380 Rrf2 family protein; Region: rrf2_super; TIGR00738 1036743012381 Transcriptional regulator; Region: Rrf2; pfam02082 1036743012382 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1036743012383 Flavoprotein; Region: Flavoprotein; pfam02441 1036743012384 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1036743012385 ABC1 family; Region: ABC1; cl17513 1036743012386 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1036743012387 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1036743012388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1036743012389 S-adenosylmethionine binding site [chemical binding]; other site 1036743012390 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1036743012391 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1036743012392 DNA binding site [nucleotide binding] 1036743012393 catalytic residue [active] 1036743012394 H2TH interface [polypeptide binding]; other site 1036743012395 putative catalytic residues [active] 1036743012396 turnover-facilitating residue; other site 1036743012397 intercalation triad [nucleotide binding]; other site 1036743012398 8OG recognition residue [nucleotide binding]; other site 1036743012399 putative reading head residues; other site 1036743012400 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1036743012401 enoyl-CoA hydratase; Provisional; Region: PRK05862 1036743012402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1036743012403 substrate binding site [chemical binding]; other site 1036743012404 oxyanion hole (OAH) forming residues; other site 1036743012405 trimer interface [polypeptide binding]; other site 1036743012406 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239