-- dump date 20140620_025134 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272943000001 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 272943000002 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272943000003 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272943000004 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272943000005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943000006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272943000007 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943000008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000009 dimer interface [polypeptide binding]; other site 272943000010 conserved gate region; other site 272943000011 putative PBP binding loops; other site 272943000012 ABC-ATPase subunit interface; other site 272943000013 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943000014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000015 dimer interface [polypeptide binding]; other site 272943000016 conserved gate region; other site 272943000017 putative PBP binding loops; other site 272943000018 ABC-ATPase subunit interface; other site 272943000019 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272943000020 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943000021 Walker A/P-loop; other site 272943000022 ATP binding site [chemical binding]; other site 272943000023 Q-loop/lid; other site 272943000024 ABC transporter signature motif; other site 272943000025 Walker B; other site 272943000026 D-loop; other site 272943000027 H-loop/switch region; other site 272943000028 TOBE domain; Region: TOBE_2; pfam08402 272943000029 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272943000030 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 272943000031 putative NAD(P) binding site [chemical binding]; other site 272943000032 catalytic Zn binding site [ion binding]; other site 272943000033 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272943000034 tetramerization interface [polypeptide binding]; other site 272943000035 NAD(P) binding site [chemical binding]; other site 272943000036 catalytic residues [active] 272943000037 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272943000038 Class I aldolases; Region: Aldolase_Class_I; cl17187 272943000039 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 272943000040 substrate binding site [chemical binding]; other site 272943000041 ATP binding site [chemical binding]; other site 272943000042 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272943000043 Right handed beta helix region; Region: Beta_helix; pfam13229 272943000044 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 272943000045 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272943000046 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272943000047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943000048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943000049 putative substrate translocation pore; other site 272943000050 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272943000051 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 272943000052 MerR family regulatory protein; Region: MerR; pfam00376 272943000053 DNA binding residues [nucleotide binding] 272943000054 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943000055 P-loop; other site 272943000056 Magnesium ion binding site [ion binding]; other site 272943000057 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 272943000058 ParB-like nuclease domain; Region: ParBc; pfam02195 272943000059 RepB plasmid partitioning protein; Region: RepB; pfam07506 272943000060 replication initiation protein RepC; Provisional; Region: PRK13824 272943000061 Replication protein C N-terminal domain; Region: RP-C; pfam03428 272943000062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943000063 putative DNA binding site [nucleotide binding]; other site 272943000064 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 272943000065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943000066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943000067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943000068 dimerization interface [polypeptide binding]; other site 272943000069 PAS fold; Region: PAS_7; pfam12860 272943000070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943000071 metal binding site [ion binding]; metal-binding site 272943000072 active site 272943000073 I-site; other site 272943000074 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272943000075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943000076 DNA-binding site [nucleotide binding]; DNA binding site 272943000077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943000078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943000079 homodimer interface [polypeptide binding]; other site 272943000080 catalytic residue [active] 272943000081 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272943000082 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272943000083 DctM-like transporters; Region: DctM; pfam06808 272943000084 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272943000085 SnoaL-like domain; Region: SnoaL_2; pfam12680 272943000086 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272943000087 FAD dependent oxidoreductase; Region: DAO; pfam01266 272943000088 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 272943000089 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272943000090 PYR/PP interface [polypeptide binding]; other site 272943000091 dimer interface [polypeptide binding]; other site 272943000092 TPP binding site [chemical binding]; other site 272943000093 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272943000094 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272943000095 TPP-binding site [chemical binding]; other site 272943000096 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 272943000097 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272943000098 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 272943000099 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272943000100 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308 272943000101 metal binding site [ion binding]; metal-binding site 272943000102 substrate binding pocket [chemical binding]; other site 272943000103 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 272943000104 classical (c) SDRs; Region: SDR_c; cd05233 272943000105 NAD(P) binding site [chemical binding]; other site 272943000106 active site 272943000107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272943000108 classical (c) SDRs; Region: SDR_c; cd05233 272943000109 NAD(P) binding site [chemical binding]; other site 272943000110 active site 272943000111 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272943000112 FAD dependent oxidoreductase; Region: DAO; pfam01266 272943000113 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 272943000114 NAD(P) binding site [chemical binding]; other site 272943000115 catalytic residues [active] 272943000116 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272943000117 inhibitor site; inhibition site 272943000118 active site 272943000119 dimer interface [polypeptide binding]; other site 272943000120 catalytic residue [active] 272943000121 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 272943000122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272943000123 DNA-binding site [nucleotide binding]; DNA binding site 272943000124 FCD domain; Region: FCD; pfam07729 272943000125 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 272943000126 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 272943000127 Walker A/P-loop; other site 272943000128 ATP binding site [chemical binding]; other site 272943000129 Q-loop/lid; other site 272943000130 ABC transporter signature motif; other site 272943000131 Walker B; other site 272943000132 D-loop; other site 272943000133 H-loop/switch region; other site 272943000134 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943000135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000136 dimer interface [polypeptide binding]; other site 272943000137 conserved gate region; other site 272943000138 putative PBP binding loops; other site 272943000139 ABC-ATPase subunit interface; other site 272943000140 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 272943000141 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272943000142 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 272943000143 conserved cys residue [active] 272943000144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943000145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943000146 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 272943000147 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272943000148 active site 272943000149 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272943000150 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943000151 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943000152 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 272943000153 Predicted membrane protein [Function unknown]; Region: COG2323 272943000154 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 272943000155 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943000156 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943000157 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272943000158 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943000159 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 272943000160 putative NAD(P) binding site [chemical binding]; other site 272943000161 active site 272943000162 putative substrate binding site [chemical binding]; other site 272943000163 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 272943000164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943000165 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 272943000166 Rhamnan synthesis protein F; Region: RgpF; pfam05045 272943000167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 272943000168 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 272943000169 Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); Region: ClassIIa_HDAC_Gln-rich-N; cl13614 272943000170 circadian clock protein KaiC; Reviewed; Region: PRK09302 272943000171 KaiC; Region: KaiC; pfam06745 272943000172 Walker A motif; other site 272943000173 ATP binding site [chemical binding]; other site 272943000174 Walker B motif; other site 272943000175 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943000176 Walker A motif; other site 272943000177 ATP binding site [chemical binding]; other site 272943000178 Walker B motif; other site 272943000179 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 272943000180 tetramer interface [polypeptide binding]; other site 272943000181 dimer interface [polypeptide binding]; other site 272943000182 PAS fold; Region: PAS_4; pfam08448 272943000183 PAS domain; Region: PAS; smart00091 272943000184 PAS domain; Region: PAS_9; pfam13426 272943000185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943000186 HWE histidine kinase; Region: HWE_HK; pfam07536 272943000187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943000188 Ligand Binding Site [chemical binding]; other site 272943000189 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272943000190 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 272943000191 FAD binding pocket [chemical binding]; other site 272943000192 FAD binding motif [chemical binding]; other site 272943000193 phosphate binding motif [ion binding]; other site 272943000194 beta-alpha-beta structure motif; other site 272943000195 NAD binding pocket [chemical binding]; other site 272943000196 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943000197 catalytic loop [active] 272943000198 iron binding site [ion binding]; other site 272943000199 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272943000200 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272943000201 [2Fe-2S] cluster binding site [ion binding]; other site 272943000202 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 272943000203 putative alpha subunit interface [polypeptide binding]; other site 272943000204 putative active site [active] 272943000205 putative substrate binding site [chemical binding]; other site 272943000206 Fe binding site [ion binding]; other site 272943000207 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 272943000208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943000209 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272943000210 dimerization interface [polypeptide binding]; other site 272943000211 substrate binding pocket [chemical binding]; other site 272943000212 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272943000213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943000214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943000215 active site 272943000216 phosphorylation site [posttranslational modification] 272943000217 intermolecular recognition site; other site 272943000218 dimerization interface [polypeptide binding]; other site 272943000219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943000220 DNA binding site [nucleotide binding] 272943000221 sensor protein QseC; Provisional; Region: PRK10337 272943000222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943000223 dimer interface [polypeptide binding]; other site 272943000224 phosphorylation site [posttranslational modification] 272943000225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943000226 ATP binding site [chemical binding]; other site 272943000227 Mg2+ binding site [ion binding]; other site 272943000228 G-X-G motif; other site 272943000229 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272943000230 transketolase; Reviewed; Region: PRK05899 272943000231 TPP-binding site [chemical binding]; other site 272943000232 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 272943000233 PYR/PP interface [polypeptide binding]; other site 272943000234 dimer interface [polypeptide binding]; other site 272943000235 TPP binding site [chemical binding]; other site 272943000236 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943000237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943000238 putative DNA binding site [nucleotide binding]; other site 272943000239 putative Zn2+ binding site [ion binding]; other site 272943000240 AsnC family; Region: AsnC_trans_reg; pfam01037 272943000241 short chain dehydrogenase; Provisional; Region: PRK12829 272943000242 classical (c) SDRs; Region: SDR_c; cd05233 272943000243 NAD(P) binding site [chemical binding]; other site 272943000244 active site 272943000245 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943000246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943000247 DNA-binding site [nucleotide binding]; DNA binding site 272943000248 FCD domain; Region: FCD; pfam07729 272943000249 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 272943000250 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272943000251 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272943000252 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 272943000253 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272943000254 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 272943000255 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272943000256 TM-ABC transporter signature motif; other site 272943000257 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272943000258 TM-ABC transporter signature motif; other site 272943000259 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943000260 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272943000261 Walker A/P-loop; other site 272943000262 ATP binding site [chemical binding]; other site 272943000263 Q-loop/lid; other site 272943000264 ABC transporter signature motif; other site 272943000265 Walker B; other site 272943000266 D-loop; other site 272943000267 H-loop/switch region; other site 272943000268 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272943000269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943000270 Walker A/P-loop; other site 272943000271 ATP binding site [chemical binding]; other site 272943000272 Q-loop/lid; other site 272943000273 ABC transporter signature motif; other site 272943000274 Walker B; other site 272943000275 D-loop; other site 272943000276 H-loop/switch region; other site 272943000277 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943000278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943000279 NAD(P) binding site [chemical binding]; other site 272943000280 active site 272943000281 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943000282 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 272943000283 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943000284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943000285 classical (c) SDRs; Region: SDR_c; cd05233 272943000286 NAD(P) binding site [chemical binding]; other site 272943000287 active site 272943000288 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 272943000289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943000290 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272943000291 dimerization interface [polypeptide binding]; other site 272943000292 substrate binding pocket [chemical binding]; other site 272943000293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943000294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272943000295 active site 272943000296 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 272943000297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943000298 NAD(P) binding site [chemical binding]; other site 272943000299 active site 272943000300 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 272943000301 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272943000302 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272943000303 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272943000304 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272943000305 active sites [active] 272943000306 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 272943000307 tetramer interface [polypeptide binding]; other site 272943000308 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272943000309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000310 dimer interface [polypeptide binding]; other site 272943000311 conserved gate region; other site 272943000312 putative PBP binding loops; other site 272943000313 ABC-ATPase subunit interface; other site 272943000314 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272943000315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000316 dimer interface [polypeptide binding]; other site 272943000317 conserved gate region; other site 272943000318 putative PBP binding loops; other site 272943000319 ABC-ATPase subunit interface; other site 272943000320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272943000321 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272943000322 substrate binding pocket [chemical binding]; other site 272943000323 membrane-bound complex binding site; other site 272943000324 hinge residues; other site 272943000325 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272943000326 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272943000327 Walker A/P-loop; other site 272943000328 ATP binding site [chemical binding]; other site 272943000329 Q-loop/lid; other site 272943000330 ABC transporter signature motif; other site 272943000331 Walker B; other site 272943000332 D-loop; other site 272943000333 H-loop/switch region; other site 272943000334 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272943000335 active site 272943000336 homotetramer interface [polypeptide binding]; other site 272943000337 homodimer interface [polypeptide binding]; other site 272943000338 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272943000339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943000340 DNA-binding site [nucleotide binding]; DNA binding site 272943000341 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272943000342 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272943000343 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943000344 Walker A/P-loop; other site 272943000345 ATP binding site [chemical binding]; other site 272943000346 Q-loop/lid; other site 272943000347 ABC transporter signature motif; other site 272943000348 Walker B; other site 272943000349 D-loop; other site 272943000350 H-loop/switch region; other site 272943000351 TOBE domain; Region: TOBE_2; pfam08402 272943000352 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272943000353 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943000354 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 272943000355 substrate binding site [chemical binding]; other site 272943000356 ATP binding site [chemical binding]; other site 272943000357 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272943000358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943000359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000360 dimer interface [polypeptide binding]; other site 272943000361 conserved gate region; other site 272943000362 putative PBP binding loops; other site 272943000363 ABC-ATPase subunit interface; other site 272943000364 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000366 dimer interface [polypeptide binding]; other site 272943000367 conserved gate region; other site 272943000368 putative PBP binding loops; other site 272943000369 ABC-ATPase subunit interface; other site 272943000370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943000371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272943000372 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272943000373 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272943000374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272943000375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272943000376 DNA binding site [nucleotide binding] 272943000377 domain linker motif; other site 272943000378 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272943000379 dimerization interface [polypeptide binding]; other site 272943000380 ligand binding site [chemical binding]; other site 272943000381 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 272943000382 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272943000383 active site 272943000384 substrate binding site [chemical binding]; other site 272943000385 metal binding site [ion binding]; metal-binding site 272943000386 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 272943000387 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272943000388 Substrate binding site; other site 272943000389 Cupin domain; Region: Cupin_2; cl17218 272943000390 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 272943000391 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272943000392 H-NS histone family; Region: Histone_HNS; pfam00816 272943000393 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 272943000394 H-NS histone family; Region: Histone_HNS; pfam00816 272943000395 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 272943000396 HipA N-terminal domain; Region: Couple_hipA; pfam13657 272943000397 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 272943000398 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272943000399 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272943000400 Sensors of blue-light using FAD; Region: BLUF; pfam04940 272943000401 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272943000402 Caspase domain; Region: Peptidase_C14; pfam00656 272943000403 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943000404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943000405 non-specific DNA binding site [nucleotide binding]; other site 272943000406 salt bridge; other site 272943000407 sequence-specific DNA binding site [nucleotide binding]; other site 272943000408 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 272943000409 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272943000410 oligomeric interface; other site 272943000411 putative active site [active] 272943000412 homodimer interface [polypeptide binding]; other site 272943000413 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272943000414 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272943000415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272943000416 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272943000417 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272943000418 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272943000419 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272943000420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272943000421 TPR motif; other site 272943000422 binding surface 272943000423 TPR repeat; Region: TPR_11; pfam13414 272943000424 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 272943000425 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 272943000426 RES domain; Region: RES; pfam08808 272943000427 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272943000428 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 272943000429 tyrosine kinase; Provisional; Region: PRK11519 272943000430 Chain length determinant protein; Region: Wzz; pfam02706 272943000431 Protein of unknown function (DUF342); Region: DUF342; cl19219 272943000432 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272943000433 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943000434 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272943000435 active site 272943000436 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272943000437 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 272943000438 SLBB domain; Region: SLBB; pfam10531 272943000439 putative acyl transferase; Provisional; Region: PRK10502 272943000440 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 272943000441 putative trimer interface [polypeptide binding]; other site 272943000442 putative active site [active] 272943000443 putative substrate binding site [chemical binding]; other site 272943000444 putative CoA binding site [chemical binding]; other site 272943000445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943000446 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 272943000447 putative ADP-binding pocket [chemical binding]; other site 272943000448 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272943000449 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272943000450 trimer interface [polypeptide binding]; other site 272943000451 active site 272943000452 substrate binding site [chemical binding]; other site 272943000453 CoA binding site [chemical binding]; other site 272943000454 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; cl10513 272943000455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943000456 S-adenosylmethionine binding site [chemical binding]; other site 272943000457 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 272943000458 PemK-like protein; Region: PemK; cl00995 272943000459 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272943000460 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272943000461 catalytic residues [active] 272943000462 catalytic nucleophile [active] 272943000463 Recombinase; Region: Recombinase; pfam07508 272943000464 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272943000465 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 272943000466 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 272943000467 NADP binding site [chemical binding]; other site 272943000468 active site 272943000469 putative substrate binding site [chemical binding]; other site 272943000470 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 272943000471 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 272943000472 NADP-binding site; other site 272943000473 homotetramer interface [polypeptide binding]; other site 272943000474 substrate binding site [chemical binding]; other site 272943000475 homodimer interface [polypeptide binding]; other site 272943000476 active site 272943000477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272943000478 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 272943000479 metal-binding site 272943000480 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 272943000481 putative active site [active] 272943000482 homotetrameric interface [polypeptide binding]; other site 272943000483 metal binding site [ion binding]; metal-binding site 272943000484 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272943000485 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 272943000486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943000487 P-loop; other site 272943000488 Magnesium ion binding site [ion binding]; other site 272943000489 ParB-like nuclease domain; Region: ParBc; cl02129 272943000490 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272943000491 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272943000492 catalytic residues [active] 272943000493 catalytic nucleophile [active] 272943000494 Presynaptic Site I dimer interface [polypeptide binding]; other site 272943000495 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272943000496 Synaptic Flat tetramer interface [polypeptide binding]; other site 272943000497 Synaptic Site I dimer interface [polypeptide binding]; other site 272943000498 DNA binding site [nucleotide binding] 272943000499 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 272943000500 heme binding pocket [chemical binding]; other site 272943000501 heme ligand [chemical binding]; other site 272943000502 PAS fold; Region: PAS_2; pfam08446 272943000503 GAF domain; Region: GAF; pfam01590 272943000504 Phytochrome region; Region: PHY; pfam00360 272943000505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943000506 metal binding site [ion binding]; metal-binding site 272943000507 active site 272943000508 I-site; other site 272943000509 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943000510 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 272943000511 ferredoxin-type protein; Provisional; Region: PRK10194 272943000512 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272943000513 NapD protein; Region: NapD; pfam03927 272943000514 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 272943000515 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 272943000516 [4Fe-4S] binding site [ion binding]; other site 272943000517 molybdopterin cofactor binding site; other site 272943000518 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 272943000519 molybdopterin cofactor binding site; other site 272943000520 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 272943000521 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 272943000522 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 272943000523 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 272943000524 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 272943000525 Protein of unknown function (DUF3620); Region: DUF3620; pfam12281 272943000526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272943000527 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272943000528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943000529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943000530 active site 272943000531 phosphorylation site [posttranslational modification] 272943000532 intermolecular recognition site; other site 272943000533 dimerization interface [polypeptide binding]; other site 272943000534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943000535 DNA binding residues [nucleotide binding] 272943000536 dimerization interface [polypeptide binding]; other site 272943000537 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943000538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 272943000539 active site 272943000540 phosphorylation site [posttranslational modification] 272943000541 intermolecular recognition site; other site 272943000542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943000543 DNA binding residues [nucleotide binding] 272943000544 dimerization interface [polypeptide binding]; other site 272943000545 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943000546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943000547 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 272943000548 DNA binding residues [nucleotide binding] 272943000549 dimerization interface [polypeptide binding]; other site 272943000550 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 272943000551 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272943000552 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943000553 P-loop; other site 272943000554 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943000555 Magnesium ion binding site [ion binding]; other site 272943000556 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 272943000557 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 272943000558 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272943000559 putative active site [active] 272943000560 Methyltransferase domain; Region: Methyltransf_27; pfam13708 272943000561 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272943000562 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 272943000563 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 272943000564 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272943000565 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 272943000566 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 272943000567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943000568 FeS/SAM binding site; other site 272943000569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272943000570 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 272943000571 active site 272943000572 catalytic residues [active] 272943000573 metal binding site [ion binding]; metal-binding site 272943000574 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 272943000575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943000576 catalytic residue [active] 272943000577 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272943000578 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272943000579 active site 272943000580 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 272943000581 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272943000582 Ligand Binding Site [chemical binding]; other site 272943000583 Molecular Tunnel; other site 272943000584 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 272943000585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 272943000586 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 272943000587 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272943000588 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 272943000589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 272943000590 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 272943000591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272943000592 Transposase; Region: HTH_Tnp_1; pfam01527 272943000593 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272943000594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272943000595 Transposase; Region: HTH_Tnp_1; cl17663 272943000596 replication initiation protein RepC; Provisional; Region: PRK13824 272943000597 Replication protein C N-terminal domain; Region: RP-C; pfam03428 272943000598 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 272943000599 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 272943000600 ParB-like nuclease domain; Region: ParB; smart00470 272943000601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272943000602 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 272943000603 MerR family regulatory protein; Region: MerR; pfam00376 272943000604 DNA binding residues [nucleotide binding] 272943000605 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943000606 P-loop; other site 272943000607 Magnesium ion binding site [ion binding]; other site 272943000608 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 272943000609 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 272943000610 putative active site [active] 272943000611 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272943000612 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272943000613 catalytic residues [active] 272943000614 catalytic nucleophile [active] 272943000615 Presynaptic Site I dimer interface [polypeptide binding]; other site 272943000616 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272943000617 Synaptic Flat tetramer interface [polypeptide binding]; other site 272943000618 Synaptic Site I dimer interface [polypeptide binding]; other site 272943000619 DNA binding site [nucleotide binding] 272943000620 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 272943000621 heme binding pocket [chemical binding]; other site 272943000622 heme ligand [chemical binding]; other site 272943000623 PAS fold; Region: PAS_2; pfam08446 272943000624 GAF domain; Region: GAF; pfam01590 272943000625 Phytochrome region; Region: PHY; pfam00360 272943000626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943000627 metal binding site [ion binding]; metal-binding site 272943000628 active site 272943000629 I-site; other site 272943000630 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943000631 PAS fold; Region: PAS; pfam00989 272943000632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943000633 putative active site [active] 272943000634 heme pocket [chemical binding]; other site 272943000635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943000636 Histidine kinase; Region: HisKA_2; pfam07568 272943000637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943000638 ATP binding site [chemical binding]; other site 272943000639 Mg2+ binding site [ion binding]; other site 272943000640 G-X-G motif; other site 272943000641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943000642 active site 272943000643 phosphorylation site [posttranslational modification] 272943000644 intermolecular recognition site; other site 272943000645 dimerization interface [polypeptide binding]; other site 272943000646 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272943000647 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272943000648 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272943000649 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272943000650 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943000651 Ligand Binding Site [chemical binding]; other site 272943000652 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943000653 Ligand Binding Site [chemical binding]; other site 272943000654 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 272943000655 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943000656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943000657 putative substrate translocation pore; other site 272943000658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943000659 dimerization interface [polypeptide binding]; other site 272943000660 putative DNA binding site [nucleotide binding]; other site 272943000661 putative Zn2+ binding site [ion binding]; other site 272943000662 Predicted permeases [General function prediction only]; Region: COG0701 272943000663 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 272943000664 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272943000665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943000666 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943000667 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272943000668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943000669 dimerization interface [polypeptide binding]; other site 272943000670 putative DNA binding site [nucleotide binding]; other site 272943000671 putative Zn2+ binding site [ion binding]; other site 272943000672 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272943000673 active site 272943000674 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 272943000675 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272943000676 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272943000677 Replication protein C N-terminal domain; Region: RP-C; pfam03428 272943000678 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 272943000679 type IV conjugative transfer system protein TraL; Region: TraL_TIGR; TIGR02762 272943000680 TraE protein; Region: TraE; cl05060 272943000681 TraK protein; Region: TraK; pfam06586 272943000682 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272943000683 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 272943000684 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 272943000685 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 272943000686 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943000687 Walker A motif; other site 272943000688 ATP binding site [chemical binding]; other site 272943000689 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515 272943000690 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272943000691 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 272943000692 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 272943000693 TraU protein; Region: TraU; pfam06834 272943000694 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 272943000695 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; cl19475 272943000696 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272943000697 F plasmid transfer operon protein; Region: TraF; pfam13728 272943000698 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 272943000699 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 272943000700 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272943000701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943000702 Coenzyme A binding pocket [chemical binding]; other site 272943000703 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943000704 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943000705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943000706 non-specific DNA binding site [nucleotide binding]; other site 272943000707 salt bridge; other site 272943000708 sequence-specific DNA binding site [nucleotide binding]; other site 272943000709 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272943000710 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272943000711 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272943000712 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 272943000713 active site 272943000714 NTP binding site [chemical binding]; other site 272943000715 metal binding triad [ion binding]; metal-binding site 272943000716 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 272943000717 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 272943000718 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 272943000719 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 272943000720 NADP binding site [chemical binding]; other site 272943000721 dimer interface [polypeptide binding]; other site 272943000722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943000723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943000724 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272943000725 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943000726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943000727 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 272943000728 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272943000729 Walker A/P-loop; other site 272943000730 ATP binding site [chemical binding]; other site 272943000731 Q-loop/lid; other site 272943000732 ABC transporter signature motif; other site 272943000733 Walker B; other site 272943000734 D-loop; other site 272943000735 H-loop/switch region; other site 272943000736 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272943000737 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943000738 ABC-ATPase subunit interface; other site 272943000739 dimer interface [polypeptide binding]; other site 272943000740 putative PBP binding regions; other site 272943000741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943000742 ABC-ATPase subunit interface; other site 272943000743 dimer interface [polypeptide binding]; other site 272943000744 putative PBP binding regions; other site 272943000745 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272943000746 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272943000747 siderophore binding site; other site 272943000748 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 272943000749 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272943000750 N-terminal plug; other site 272943000751 ligand-binding site [chemical binding]; other site 272943000752 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943000753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943000754 putative DNA binding site [nucleotide binding]; other site 272943000755 putative Zn2+ binding site [ion binding]; other site 272943000756 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272943000757 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272943000758 nucleotide binding site [chemical binding]; other site 272943000759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272943000760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943000761 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272943000762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000763 dimer interface [polypeptide binding]; other site 272943000764 conserved gate region; other site 272943000765 putative PBP binding loops; other site 272943000766 ABC-ATPase subunit interface; other site 272943000767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000769 dimer interface [polypeptide binding]; other site 272943000770 conserved gate region; other site 272943000771 putative PBP binding loops; other site 272943000772 ABC-ATPase subunit interface; other site 272943000773 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272943000774 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943000775 Walker A/P-loop; other site 272943000776 ATP binding site [chemical binding]; other site 272943000777 Q-loop/lid; other site 272943000778 ABC transporter signature motif; other site 272943000779 Walker B; other site 272943000780 D-loop; other site 272943000781 H-loop/switch region; other site 272943000782 TOBE domain; Region: TOBE_2; pfam08402 272943000783 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272943000784 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272943000785 nucleotide binding site [chemical binding]; other site 272943000786 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272943000787 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272943000788 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272943000789 dimer interface [polypeptide binding]; other site 272943000790 active site 272943000791 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943000792 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272943000793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943000794 catalytic residue [active] 272943000795 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272943000796 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272943000797 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272943000798 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 272943000799 active site 272943000800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943000801 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272943000802 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943000803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000804 dimer interface [polypeptide binding]; other site 272943000805 conserved gate region; other site 272943000806 putative PBP binding loops; other site 272943000807 ABC-ATPase subunit interface; other site 272943000808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272943000809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000810 dimer interface [polypeptide binding]; other site 272943000811 conserved gate region; other site 272943000812 putative PBP binding loops; other site 272943000813 ABC-ATPase subunit interface; other site 272943000814 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272943000815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943000816 Walker A/P-loop; other site 272943000817 ATP binding site [chemical binding]; other site 272943000818 Q-loop/lid; other site 272943000819 ABC transporter signature motif; other site 272943000820 Walker B; other site 272943000821 D-loop; other site 272943000822 H-loop/switch region; other site 272943000823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943000824 Walker A/P-loop; other site 272943000825 ATP binding site [chemical binding]; other site 272943000826 Q-loop/lid; other site 272943000827 ABC transporter signature motif; other site 272943000828 Walker B; other site 272943000829 D-loop; other site 272943000830 H-loop/switch region; other site 272943000831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943000832 allantoate amidohydrolase; Reviewed; Region: PRK09290 272943000833 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272943000834 active site 272943000835 metal binding site [ion binding]; metal-binding site 272943000836 dimer interface [polypeptide binding]; other site 272943000837 Phosphotransferase enzyme family; Region: APH; pfam01636 272943000838 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272943000839 active site 272943000840 ATP binding site [chemical binding]; other site 272943000841 substrate binding site [chemical binding]; other site 272943000842 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 272943000843 Phosphotransferase enzyme family; Region: APH; pfam01636 272943000844 active site 272943000845 ATP binding site [chemical binding]; other site 272943000846 substrate binding site [chemical binding]; other site 272943000847 dimer interface [polypeptide binding]; other site 272943000848 DNA Polymerase Y-family; Region: PolY_like; cd03468 272943000849 active site 272943000850 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272943000851 DNA binding site [nucleotide binding] 272943000852 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 272943000853 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 272943000854 putative metal binding site [ion binding]; other site 272943000855 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272943000856 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 272943000857 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 272943000858 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272943000859 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 272943000860 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 272943000861 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272943000862 Thioredoxin; Region: Thioredoxin_4; pfam13462 272943000863 Protein of unknown function (DUF721); Region: DUF721; pfam05258 272943000864 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272943000865 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272943000866 minor groove reading motif; other site 272943000867 helix-hairpin-helix signature motif; other site 272943000868 substrate binding pocket [chemical binding]; other site 272943000869 active site 272943000870 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272943000871 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272943000872 DNA binding and oxoG recognition site [nucleotide binding] 272943000873 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 272943000874 Di-iron ligands [ion binding]; other site 272943000875 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272943000876 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272943000877 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272943000878 RNA/DNA hybrid binding site [nucleotide binding]; other site 272943000879 active site 272943000880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943000881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 272943000882 DNA binding site [nucleotide binding] 272943000883 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 272943000884 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 272943000885 dimer interface [polypeptide binding]; other site 272943000886 active site 272943000887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272943000888 catalytic residues [active] 272943000889 substrate binding site [chemical binding]; other site 272943000890 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 272943000891 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272943000892 NAD(P) binding pocket [chemical binding]; other site 272943000893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943000894 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272943000895 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272943000896 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272943000897 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 272943000898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943000899 Walker A/P-loop; other site 272943000900 ATP binding site [chemical binding]; other site 272943000901 Q-loop/lid; other site 272943000902 ABC transporter signature motif; other site 272943000903 Walker B; other site 272943000904 D-loop; other site 272943000905 H-loop/switch region; other site 272943000906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272943000907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943000908 Walker A/P-loop; other site 272943000909 ATP binding site [chemical binding]; other site 272943000910 Q-loop/lid; other site 272943000911 ABC transporter signature motif; other site 272943000912 Walker B; other site 272943000913 D-loop; other site 272943000914 H-loop/switch region; other site 272943000915 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943000916 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943000917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000918 dimer interface [polypeptide binding]; other site 272943000919 conserved gate region; other site 272943000920 putative PBP binding loops; other site 272943000921 ABC-ATPase subunit interface; other site 272943000922 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 272943000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943000924 dimer interface [polypeptide binding]; other site 272943000925 conserved gate region; other site 272943000926 putative PBP binding loops; other site 272943000927 ABC-ATPase subunit interface; other site 272943000928 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272943000929 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272943000930 peptide binding site [polypeptide binding]; other site 272943000931 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272943000932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272943000933 ATP binding site [chemical binding]; other site 272943000934 putative Mg++ binding site [ion binding]; other site 272943000935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943000936 nucleotide binding region [chemical binding]; other site 272943000937 ATP-binding site [chemical binding]; other site 272943000938 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 272943000939 RNA binding site [nucleotide binding]; other site 272943000940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943000941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943000942 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 272943000943 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272943000944 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272943000945 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 272943000946 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 272943000947 Tetratricopeptide repeat; Region: TPR_20; pfam14561 272943000948 ATP-dependent protease La (LON) domain; Region: LON; cl19481 272943000949 Uncharacterized conserved protein [Function unknown]; Region: COG2835 272943000950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943000951 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 272943000952 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 272943000953 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 272943000954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943000955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943000956 homodimer interface [polypeptide binding]; other site 272943000957 catalytic residue [active] 272943000958 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272943000959 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272943000960 AAA-like domain; Region: AAA_10; pfam12846 272943000961 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272943000962 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 272943000963 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943000964 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943000965 catalytic residue [active] 272943000966 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 272943000967 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272943000968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943000969 ATP binding site [chemical binding]; other site 272943000970 Mg2+ binding site [ion binding]; other site 272943000971 G-X-G motif; other site 272943000972 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272943000973 anti sigma factor interaction site; other site 272943000974 regulatory phosphorylation site [posttranslational modification]; other site 272943000975 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272943000976 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272943000977 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272943000978 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272943000979 active site 272943000980 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272943000981 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 272943000982 active site 272943000983 metal binding site [ion binding]; metal-binding site 272943000984 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 272943000985 NAD binding site [chemical binding]; other site 272943000986 catalytic residues [active] 272943000987 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 272943000988 HemY protein N-terminus; Region: HemY_N; pfam07219 272943000989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 272943000990 active site 272943000991 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 272943000992 UGMP family protein; Validated; Region: PRK09604 272943000993 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272943000994 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272943000995 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272943000996 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272943000997 YciI-like protein; Reviewed; Region: PRK12863 272943000998 EVE domain; Region: EVE; cl00728 272943000999 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272943001000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943001001 catalytic residue [active] 272943001002 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 272943001003 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 272943001004 homotetramer interface [polypeptide binding]; other site 272943001005 ligand binding site [chemical binding]; other site 272943001006 catalytic site [active] 272943001007 NAD binding site [chemical binding]; other site 272943001008 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 272943001009 Ligand binding site; other site 272943001010 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272943001011 metal-binding site 272943001012 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 272943001013 K-box region; Region: K-box; pfam01486 272943001014 H-NS histone family; Region: Histone_HNS; pfam00816 272943001015 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 272943001016 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 272943001017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001018 active site 272943001019 phosphorylation site [posttranslational modification] 272943001020 intermolecular recognition site; other site 272943001021 dimerization interface [polypeptide binding]; other site 272943001022 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272943001023 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272943001024 Cu(I) binding site [ion binding]; other site 272943001025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943001026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943001027 dimer interface [polypeptide binding]; other site 272943001028 phosphorylation site [posttranslational modification] 272943001029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943001030 ATP binding site [chemical binding]; other site 272943001031 Mg2+ binding site [ion binding]; other site 272943001032 G-X-G motif; other site 272943001033 PAS fold; Region: PAS_7; pfam12860 272943001034 PAS fold; Region: PAS_7; pfam12860 272943001035 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272943001036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943001037 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272943001038 Walker A motif; other site 272943001039 ATP binding site [chemical binding]; other site 272943001040 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 272943001041 Phosphotransferase enzyme family; Region: APH; pfam01636 272943001042 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272943001043 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 272943001044 Substrate binding site; other site 272943001045 metal-binding site 272943001046 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 272943001047 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 272943001048 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272943001049 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 272943001050 Part of AAA domain; Region: AAA_19; pfam13245 272943001051 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272943001052 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272943001053 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272943001054 catalytic residues [active] 272943001055 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272943001056 active site 272943001057 HslU subunit interaction site [polypeptide binding]; other site 272943001058 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272943001059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943001060 Walker A motif; other site 272943001061 ATP binding site [chemical binding]; other site 272943001062 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272943001063 Walker B motif; other site 272943001064 arginine finger; other site 272943001065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272943001066 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272943001067 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272943001068 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 272943001069 Acid Phosphatase; Region: Acid_PPase; cl17256 272943001070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943001071 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272943001072 active site 2 [active] 272943001073 active site 1 [active] 272943001074 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272943001075 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 272943001076 substrate binding site; other site 272943001077 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272943001078 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272943001079 active site 272943001080 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 272943001081 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272943001082 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272943001083 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272943001084 Walker A/P-loop; other site 272943001085 ATP binding site [chemical binding]; other site 272943001086 Q-loop/lid; other site 272943001087 ABC transporter signature motif; other site 272943001088 Walker B; other site 272943001089 D-loop; other site 272943001090 H-loop/switch region; other site 272943001091 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 272943001092 Imelysin; Region: Peptidase_M75; pfam09375 272943001093 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 272943001094 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 272943001095 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 272943001096 Ferritin-like domain; Region: Ferritin; pfam00210 272943001097 heme binding site [chemical binding]; other site 272943001098 ferroxidase pore; other site 272943001099 ferroxidase diiron center [ion binding]; other site 272943001100 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272943001101 Imelysin; Region: Peptidase_M75; cl09159 272943001102 Hemin uptake protein hemP; Region: hemP; pfam10636 272943001103 Protein of unknown function (DUF533); Region: DUF533; pfam04391 272943001104 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 272943001105 putative metal binding site [ion binding]; other site 272943001106 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272943001107 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272943001108 Bacterial transcriptional regulator; Region: IclR; pfam01614 272943001109 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272943001110 ureidoglycolate hydrolase; Provisional; Region: PRK03606 272943001111 hypothetical protein; Provisional; Region: PRK11171 272943001112 Cupin domain; Region: Cupin_2; pfam07883 272943001113 Cupin domain; Region: Cupin_2; pfam07883 272943001114 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 272943001115 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 272943001116 active site 272943001117 catalytic site [active] 272943001118 tetramer interface [polypeptide binding]; other site 272943001119 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 272943001120 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 272943001121 active site 272943001122 homotetramer interface [polypeptide binding]; other site 272943001123 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272943001124 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272943001125 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272943001126 isocitrate dehydrogenase; Validated; Region: PRK08299 272943001127 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272943001128 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272943001129 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272943001130 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272943001131 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 272943001132 acyl-activating enzyme (AAE) consensus motif; other site 272943001133 putative AMP binding site [chemical binding]; other site 272943001134 putative active site [active] 272943001135 putative CoA binding site [chemical binding]; other site 272943001136 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272943001137 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272943001138 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 272943001139 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 272943001140 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272943001141 Sensors of blue-light using FAD; Region: BLUF; smart01034 272943001142 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 272943001143 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 272943001144 putative active site [active] 272943001145 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272943001146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943001147 putative active site [active] 272943001148 heme pocket [chemical binding]; other site 272943001149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943001150 dimer interface [polypeptide binding]; other site 272943001151 phosphorylation site [posttranslational modification] 272943001152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943001153 ATP binding site [chemical binding]; other site 272943001154 Mg2+ binding site [ion binding]; other site 272943001155 G-X-G motif; other site 272943001156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943001157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001158 active site 272943001159 phosphorylation site [posttranslational modification] 272943001160 intermolecular recognition site; other site 272943001161 dimerization interface [polypeptide binding]; other site 272943001162 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272943001163 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272943001164 aminotransferase; Validated; Region: PRK07046 272943001165 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 272943001166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943001167 catalytic residue [active] 272943001168 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272943001169 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272943001170 AIR carboxylase; Region: AIRC; pfam00731 272943001171 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 272943001172 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272943001173 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272943001174 putative dimer interface [polypeptide binding]; other site 272943001175 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 272943001176 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272943001177 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 272943001178 ATP-sulfurylase; Region: ATPS; cd00517 272943001179 active site 272943001180 HXXH motif; other site 272943001181 flexible loop; other site 272943001182 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272943001183 ligand-binding site [chemical binding]; other site 272943001184 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272943001185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943001186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943001187 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943001188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943001189 putative DNA binding site [nucleotide binding]; other site 272943001190 putative Zn2+ binding site [ion binding]; other site 272943001191 AsnC family; Region: AsnC_trans_reg; pfam01037 272943001192 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272943001193 Uncharacterized conserved protein [Function unknown]; Region: COG1565 272943001194 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 272943001195 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272943001196 Membrane fusogenic activity; Region: BMFP; pfam04380 272943001197 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272943001198 anti sigma factor interaction site; other site 272943001199 regulatory phosphorylation site [posttranslational modification]; other site 272943001200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001201 active site 272943001202 phosphorylation site [posttranslational modification] 272943001203 intermolecular recognition site; other site 272943001204 dimerization interface [polypeptide binding]; other site 272943001205 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272943001206 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272943001207 putative binding surface; other site 272943001208 active site 272943001209 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272943001210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943001211 ATP binding site [chemical binding]; other site 272943001212 Mg2+ binding site [ion binding]; other site 272943001213 G-X-G motif; other site 272943001214 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272943001215 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 272943001216 putative CheA interaction surface; other site 272943001217 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 272943001218 putative CheA interaction surface; other site 272943001219 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 272943001220 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272943001221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943001222 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272943001223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001224 active site 272943001225 phosphorylation site [posttranslational modification] 272943001226 intermolecular recognition site; other site 272943001227 dimerization interface [polypeptide binding]; other site 272943001228 CheB methylesterase; Region: CheB_methylest; pfam01339 272943001229 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 272943001230 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 272943001231 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 272943001232 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 272943001233 putative dimer interface [polypeptide binding]; other site 272943001234 N-terminal domain interface [polypeptide binding]; other site 272943001235 putative substrate binding pocket (H-site) [chemical binding]; other site 272943001236 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272943001237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001238 active site 272943001239 phosphorylation site [posttranslational modification] 272943001240 intermolecular recognition site; other site 272943001241 dimerization interface [polypeptide binding]; other site 272943001242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943001243 Walker A motif; other site 272943001244 ATP binding site [chemical binding]; other site 272943001245 Walker B motif; other site 272943001246 arginine finger; other site 272943001247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943001248 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 272943001249 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 272943001250 acyl-activating enzyme (AAE) consensus motif; other site 272943001251 putative AMP binding site [chemical binding]; other site 272943001252 putative active site [active] 272943001253 putative CoA binding site [chemical binding]; other site 272943001254 malic enzyme; Reviewed; Region: PRK12862 272943001255 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272943001256 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272943001257 putative NAD(P) binding site [chemical binding]; other site 272943001258 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272943001259 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 272943001260 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272943001261 active site 272943001262 catalytic motif [active] 272943001263 Zn binding site [ion binding]; other site 272943001264 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 272943001265 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272943001266 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272943001267 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 272943001268 phosphopentomutase; Provisional; Region: PRK05362 272943001269 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 272943001270 active site 272943001271 purine riboside binding site [chemical binding]; other site 272943001272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943001273 active site 272943001274 Sporulation related domain; Region: SPOR; pfam05036 272943001275 acyl-CoA synthetase; Validated; Region: PRK08162 272943001276 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 272943001277 acyl-activating enzyme (AAE) consensus motif; other site 272943001278 putative active site [active] 272943001279 AMP binding site [chemical binding]; other site 272943001280 putative CoA binding site [chemical binding]; other site 272943001281 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943001282 EamA-like transporter family; Region: EamA; pfam00892 272943001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943001284 S-adenosylmethionine binding site [chemical binding]; other site 272943001285 DctM-like transporters; Region: DctM; pfam06808 272943001286 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272943001287 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 272943001288 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272943001289 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272943001290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943001291 DNA-binding site [nucleotide binding]; DNA binding site 272943001292 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272943001293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272943001294 DNA-binding site [nucleotide binding]; DNA binding site 272943001295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272943001296 DNA-binding site [nucleotide binding]; DNA binding site 272943001297 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943001298 FCD domain; Region: FCD; pfam07729 272943001299 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 272943001300 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272943001301 putative NAD(P) binding site [chemical binding]; other site 272943001302 catalytic Zn binding site [ion binding]; other site 272943001303 structural Zn binding site [ion binding]; other site 272943001304 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272943001305 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272943001306 galactarate dehydratase; Region: galactar-dH20; TIGR03248 272943001307 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 272943001308 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 272943001309 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 272943001310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943001311 ATP binding site [chemical binding]; other site 272943001312 Mg2+ binding site [ion binding]; other site 272943001313 G-X-G motif; other site 272943001314 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272943001315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001316 active site 272943001317 phosphorylation site [posttranslational modification] 272943001318 intermolecular recognition site; other site 272943001319 dimerization interface [polypeptide binding]; other site 272943001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943001321 Walker A motif; other site 272943001322 ATP binding site [chemical binding]; other site 272943001323 Walker B motif; other site 272943001324 arginine finger; other site 272943001325 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943001326 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272943001327 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272943001328 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 272943001329 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272943001330 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 272943001331 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 272943001332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272943001333 Zn2+ binding site [ion binding]; other site 272943001334 Mg2+ binding site [ion binding]; other site 272943001335 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943001336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943001337 non-specific DNA binding site [nucleotide binding]; other site 272943001338 salt bridge; other site 272943001339 sequence-specific DNA binding site [nucleotide binding]; other site 272943001340 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 272943001341 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943001342 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 272943001343 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272943001344 PAS fold; Region: PAS_4; pfam08448 272943001345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943001346 putative active site [active] 272943001347 heme pocket [chemical binding]; other site 272943001348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943001349 HWE histidine kinase; Region: HWE_HK; smart00911 272943001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272943001351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001352 active site 272943001353 phosphorylation site [posttranslational modification] 272943001354 intermolecular recognition site; other site 272943001355 dimerization interface [polypeptide binding]; other site 272943001356 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272943001357 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 272943001358 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272943001359 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272943001360 oligomerization interface [polypeptide binding]; other site 272943001361 Phage capsid family; Region: Phage_capsid; pfam05065 272943001362 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943001363 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 272943001364 tandem repeat interface [polypeptide binding]; other site 272943001365 oligomer interface [polypeptide binding]; other site 272943001366 active site residues [active] 272943001367 Phage portal protein; Region: Phage_portal; pfam04860 272943001368 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 272943001369 EamA-like transporter family; Region: EamA; cl17759 272943001370 IMG reference gene:2512953550; ykkC-yxkD leader; RSP_7704 272943001371 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272943001372 Phage Terminase; Region: Terminase_1; cl19862 272943001373 Phage terminase, small subunit; Region: Terminase_4; pfam05119 272943001374 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943001375 active site 272943001376 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 272943001377 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943001378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943001379 non-specific DNA binding site [nucleotide binding]; other site 272943001380 salt bridge; other site 272943001381 sequence-specific DNA binding site [nucleotide binding]; other site 272943001382 Phasin protein; Region: Phasin_2; cl11491 272943001383 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272943001384 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272943001385 DNA binding residues [nucleotide binding] 272943001386 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272943001387 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272943001388 active site 272943001389 catalytic residues [active] 272943001390 DNA binding site [nucleotide binding] 272943001391 Int/Topo IB signature motif; other site 272943001392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272943001393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272943001394 DNA binding site [nucleotide binding] 272943001395 domain linker motif; other site 272943001396 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 272943001397 putative dimerization interface [polypeptide binding]; other site 272943001398 putative ligand binding site [chemical binding]; other site 272943001399 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 272943001400 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272943001401 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 272943001402 Fe-S cluster binding site [ion binding]; other site 272943001403 substrate binding site [chemical binding]; other site 272943001404 catalytic site [active] 272943001405 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272943001406 LabA_like proteins; Region: LabA; cd10911 272943001407 putative metal binding site [ion binding]; other site 272943001408 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 272943001409 catalytic center binding site [active] 272943001410 ATP binding site [chemical binding]; other site 272943001411 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272943001412 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272943001413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272943001414 Zn2+ binding site [ion binding]; other site 272943001415 Mg2+ binding site [ion binding]; other site 272943001416 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272943001417 synthetase active site [active] 272943001418 NTP binding site [chemical binding]; other site 272943001419 metal binding site [ion binding]; metal-binding site 272943001420 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272943001421 ACT domain; Region: ACT_4; pfam13291 272943001422 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 272943001423 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 272943001424 active site 272943001425 hydrophilic channel; other site 272943001426 dimerization interface [polypeptide binding]; other site 272943001427 catalytic residues [active] 272943001428 active site lid [active] 272943001429 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272943001430 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272943001431 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272943001432 Catalytic site [active] 272943001433 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 272943001434 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272943001435 dimerization interface [polypeptide binding]; other site 272943001436 active site 272943001437 metal binding site [ion binding]; metal-binding site 272943001438 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272943001439 dsRNA binding site [nucleotide binding]; other site 272943001440 GTPase Era; Reviewed; Region: era; PRK00089 272943001441 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272943001442 G1 box; other site 272943001443 GTP/Mg2+ binding site [chemical binding]; other site 272943001444 Switch I region; other site 272943001445 G2 box; other site 272943001446 Switch II region; other site 272943001447 G3 box; other site 272943001448 G4 box; other site 272943001449 G5 box; other site 272943001450 KH domain; Region: KH_2; pfam07650 272943001451 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 272943001452 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272943001453 Recombination protein O N terminal; Region: RecO_N; pfam11967 272943001454 Recombination protein O C terminal; Region: RecO_C; pfam02565 272943001455 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943001456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272943001457 active site 272943001458 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 272943001459 active site 272943001460 substrate-binding site [chemical binding]; other site 272943001461 metal-binding site [ion binding] 272943001462 ATP binding site [chemical binding]; other site 272943001463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001465 active site 272943001466 phosphorylation site [posttranslational modification] 272943001467 intermolecular recognition site; other site 272943001468 dimerization interface [polypeptide binding]; other site 272943001469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943001470 DNA binding site [nucleotide binding] 272943001471 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 272943001472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943001473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943001474 dimer interface [polypeptide binding]; other site 272943001475 phosphorylation site [posttranslational modification] 272943001476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943001477 ATP binding site [chemical binding]; other site 272943001478 Mg2+ binding site [ion binding]; other site 272943001479 G-X-G motif; other site 272943001480 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272943001481 Hpr binding site; other site 272943001482 active site 272943001483 homohexamer subunit interaction site [polypeptide binding]; other site 272943001484 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 272943001485 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272943001486 active pocket/dimerization site; other site 272943001487 active site 272943001488 phosphorylation site [posttranslational modification] 272943001489 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272943001490 dimerization domain swap beta strand [polypeptide binding]; other site 272943001491 regulatory protein interface [polypeptide binding]; other site 272943001492 active site 272943001493 regulatory phosphorylation site [posttranslational modification]; other site 272943001494 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272943001495 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 272943001496 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272943001497 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272943001498 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272943001499 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 272943001500 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272943001501 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272943001502 Ligand binding site [chemical binding]; other site 272943001503 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 272943001504 short chain dehydrogenase; Validated; Region: PRK06182 272943001505 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272943001506 NADP binding site [chemical binding]; other site 272943001507 active site 272943001508 steroid binding site; other site 272943001509 Bacterial SH3 domain homologues; Region: SH3b; smart00287 272943001510 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272943001511 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272943001512 CAP-like domain; other site 272943001513 active site 272943001514 primary dimer interface [polypeptide binding]; other site 272943001515 elongation factor Tu; Reviewed; Region: PRK00049 272943001516 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272943001517 G1 box; other site 272943001518 GEF interaction site [polypeptide binding]; other site 272943001519 GTP/Mg2+ binding site [chemical binding]; other site 272943001520 Switch I region; other site 272943001521 G2 box; other site 272943001522 G3 box; other site 272943001523 Switch II region; other site 272943001524 G4 box; other site 272943001525 G5 box; other site 272943001526 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272943001527 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272943001528 Antibiotic Binding Site [chemical binding]; other site 272943001529 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 272943001530 trimer interface [polypeptide binding]; other site 272943001531 active site 272943001532 substrate binding site [chemical binding]; other site 272943001533 CoA binding site [chemical binding]; other site 272943001534 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 272943001535 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272943001536 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272943001537 putative homodimer interface [polypeptide binding]; other site 272943001538 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272943001539 heterodimer interface [polypeptide binding]; other site 272943001540 homodimer interface [polypeptide binding]; other site 272943001541 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272943001542 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272943001543 23S rRNA interface [nucleotide binding]; other site 272943001544 L7/L12 interface [polypeptide binding]; other site 272943001545 putative thiostrepton binding site; other site 272943001546 L25 interface [polypeptide binding]; other site 272943001547 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272943001548 mRNA/rRNA interface [nucleotide binding]; other site 272943001549 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272943001550 23S rRNA interface [nucleotide binding]; other site 272943001551 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272943001552 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272943001553 core dimer interface [polypeptide binding]; other site 272943001554 peripheral dimer interface [polypeptide binding]; other site 272943001555 L10 interface [polypeptide binding]; other site 272943001556 L11 interface [polypeptide binding]; other site 272943001557 putative EF-Tu interaction site [polypeptide binding]; other site 272943001558 putative EF-G interaction site [polypeptide binding]; other site 272943001559 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272943001560 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272943001561 RPB12 interaction site [polypeptide binding]; other site 272943001562 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 272943001563 RPB1 interaction site [polypeptide binding]; other site 272943001564 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272943001565 RPB10 interaction site [polypeptide binding]; other site 272943001566 RPB11 interaction site [polypeptide binding]; other site 272943001567 RPB3 interaction site [polypeptide binding]; other site 272943001568 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272943001569 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272943001570 beta and beta' interface [polypeptide binding]; other site 272943001571 beta' and sigma factor interface [polypeptide binding]; other site 272943001572 Zn-binding [ion binding]; other site 272943001573 active site region [active] 272943001574 catalytic site [active] 272943001575 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272943001576 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272943001577 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272943001578 cleft; other site 272943001579 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272943001580 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272943001581 G-loop; other site 272943001582 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 272943001583 DNA binding site [nucleotide binding] 272943001584 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943001585 EamA-like transporter family; Region: EamA; pfam00892 272943001586 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272943001587 S17 interaction site [polypeptide binding]; other site 272943001588 S8 interaction site; other site 272943001589 16S rRNA interaction site [nucleotide binding]; other site 272943001590 streptomycin interaction site [chemical binding]; other site 272943001591 23S rRNA interaction site [nucleotide binding]; other site 272943001592 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272943001593 30S ribosomal protein S7; Validated; Region: PRK05302 272943001594 elongation factor G; Reviewed; Region: PRK00007 272943001595 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272943001596 G1 box; other site 272943001597 putative GEF interaction site [polypeptide binding]; other site 272943001598 GTP/Mg2+ binding site [chemical binding]; other site 272943001599 Switch I region; other site 272943001600 G2 box; other site 272943001601 G3 box; other site 272943001602 Switch II region; other site 272943001603 G4 box; other site 272943001604 G5 box; other site 272943001605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272943001606 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272943001607 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272943001608 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272943001609 elongation factor Tu; Reviewed; Region: PRK00049 272943001610 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272943001611 G1 box; other site 272943001612 GEF interaction site [polypeptide binding]; other site 272943001613 GTP/Mg2+ binding site [chemical binding]; other site 272943001614 Switch I region; other site 272943001615 G2 box; other site 272943001616 G3 box; other site 272943001617 Switch II region; other site 272943001618 G4 box; other site 272943001619 G5 box; other site 272943001620 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272943001621 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272943001622 Antibiotic Binding Site [chemical binding]; other site 272943001623 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272943001624 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272943001625 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272943001626 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272943001627 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272943001628 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272943001629 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272943001630 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272943001631 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272943001632 putative translocon binding site; other site 272943001633 protein-rRNA interface [nucleotide binding]; other site 272943001634 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272943001635 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272943001636 G-X-X-G motif; other site 272943001637 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272943001638 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272943001639 23S rRNA interface [nucleotide binding]; other site 272943001640 5S rRNA interface [nucleotide binding]; other site 272943001641 putative antibiotic binding site [chemical binding]; other site 272943001642 L25 interface [polypeptide binding]; other site 272943001643 L27 interface [polypeptide binding]; other site 272943001644 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272943001645 23S rRNA interface [nucleotide binding]; other site 272943001646 putative translocon interaction site; other site 272943001647 signal recognition particle (SRP54) interaction site; other site 272943001648 L23 interface [polypeptide binding]; other site 272943001649 trigger factor interaction site; other site 272943001650 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272943001651 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272943001652 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272943001653 RNA binding site [nucleotide binding]; other site 272943001654 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272943001655 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272943001656 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272943001657 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272943001658 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272943001659 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272943001660 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272943001661 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272943001662 5S rRNA interface [nucleotide binding]; other site 272943001663 23S rRNA interface [nucleotide binding]; other site 272943001664 L5 interface [polypeptide binding]; other site 272943001665 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272943001666 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272943001667 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272943001668 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272943001669 23S rRNA binding site [nucleotide binding]; other site 272943001670 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272943001671 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272943001672 SecY translocase; Region: SecY; pfam00344 272943001673 adenylate kinase; Reviewed; Region: adk; PRK00279 272943001674 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272943001675 AMP-binding site [chemical binding]; other site 272943001676 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272943001677 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272943001678 30S ribosomal protein S11; Validated; Region: PRK05309 272943001679 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272943001680 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272943001681 alphaNTD - beta interaction site [polypeptide binding]; other site 272943001682 alphaNTD homodimer interface [polypeptide binding]; other site 272943001683 alphaNTD - beta' interaction site [polypeptide binding]; other site 272943001684 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272943001685 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272943001686 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943001687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272943001688 DNA binding residues [nucleotide binding] 272943001689 dimerization interface [polypeptide binding]; other site 272943001690 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272943001691 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272943001692 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272943001693 protein binding site [polypeptide binding]; other site 272943001694 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272943001695 protein binding site [polypeptide binding]; other site 272943001696 recombination factor protein RarA; Reviewed; Region: PRK13342 272943001697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943001698 Walker A motif; other site 272943001699 ATP binding site [chemical binding]; other site 272943001700 Walker B motif; other site 272943001701 arginine finger; other site 272943001702 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272943001703 camphor resistance protein CrcB; Provisional; Region: PRK14209 272943001704 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272943001705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272943001706 RNA binding surface [nucleotide binding]; other site 272943001707 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272943001708 active site 272943001709 ATP12 chaperone protein; Region: ATP12; pfam07542 272943001710 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 272943001711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272943001712 substrate binding pocket [chemical binding]; other site 272943001713 membrane-bound complex binding site; other site 272943001714 hinge residues; other site 272943001715 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 272943001716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272943001717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943001718 dimer interface [polypeptide binding]; other site 272943001719 conserved gate region; other site 272943001720 putative PBP binding loops; other site 272943001721 ABC-ATPase subunit interface; other site 272943001722 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 272943001723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943001724 dimer interface [polypeptide binding]; other site 272943001725 conserved gate region; other site 272943001726 putative PBP binding loops; other site 272943001727 ABC-ATPase subunit interface; other site 272943001728 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272943001729 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272943001730 Walker A/P-loop; other site 272943001731 ATP binding site [chemical binding]; other site 272943001732 Q-loop/lid; other site 272943001733 ABC transporter signature motif; other site 272943001734 Walker B; other site 272943001735 D-loop; other site 272943001736 H-loop/switch region; other site 272943001737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943001738 catalytic loop [active] 272943001739 iron binding site [ion binding]; other site 272943001740 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272943001741 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272943001742 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 272943001743 active site 272943001744 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 272943001745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272943001746 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943001747 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 272943001748 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272943001749 oligomerization interface [polypeptide binding]; other site 272943001750 active site 272943001751 metal binding site [ion binding]; metal-binding site 272943001752 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272943001753 active site 272943001754 ATP-binding site [chemical binding]; other site 272943001755 pantoate-binding site; other site 272943001756 HXXH motif; other site 272943001757 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 272943001758 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272943001759 metal binding site [ion binding]; metal-binding site 272943001760 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 272943001761 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272943001762 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272943001763 putative tRNA-binding site [nucleotide binding]; other site 272943001764 B3/4 domain; Region: B3_4; pfam03483 272943001765 tRNA synthetase B5 domain; Region: B5; smart00874 272943001766 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272943001767 dimer interface [polypeptide binding]; other site 272943001768 motif 1; other site 272943001769 motif 3; other site 272943001770 motif 2; other site 272943001771 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 272943001772 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272943001773 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272943001774 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272943001775 dimer interface [polypeptide binding]; other site 272943001776 motif 1; other site 272943001777 active site 272943001778 motif 2; other site 272943001779 motif 3; other site 272943001780 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272943001781 23S rRNA binding site [nucleotide binding]; other site 272943001782 L21 binding site [polypeptide binding]; other site 272943001783 L13 binding site [polypeptide binding]; other site 272943001784 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272943001785 pyruvate kinase; Provisional; Region: PRK06247 272943001786 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272943001787 domain interfaces; other site 272943001788 active site 272943001789 N-formylglutamate amidohydrolase; Region: FGase; cl01522 272943001790 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272943001791 homodimer interface [polypeptide binding]; other site 272943001792 substrate-cofactor binding pocket; other site 272943001793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943001794 catalytic residue [active] 272943001795 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272943001796 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 272943001797 active site 272943001798 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 272943001799 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 272943001800 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 272943001801 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272943001802 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272943001803 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 272943001804 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 272943001805 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272943001806 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272943001807 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272943001808 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 272943001809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943001810 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 272943001811 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272943001812 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 272943001813 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272943001814 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 272943001815 Predicted membrane protein [Function unknown]; Region: COG4244 272943001816 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272943001817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943001818 active site 272943001819 phosphorylation site [posttranslational modification] 272943001820 intermolecular recognition site; other site 272943001821 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272943001822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272943001823 DNA binding site [nucleotide binding] 272943001824 domain linker motif; other site 272943001825 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 272943001826 putative dimerization interface [polypeptide binding]; other site 272943001827 putative ligand binding site [chemical binding]; other site 272943001828 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272943001829 active site 272943001830 phosphorylation site [posttranslational modification] 272943001831 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272943001832 dimerization domain swap beta strand [polypeptide binding]; other site 272943001833 regulatory protein interface [polypeptide binding]; other site 272943001834 active site 272943001835 regulatory phosphorylation site [posttranslational modification]; other site 272943001836 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272943001837 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272943001838 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272943001839 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272943001840 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272943001841 putative substrate binding site [chemical binding]; other site 272943001842 putative ATP binding site [chemical binding]; other site 272943001843 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272943001844 active site 272943001845 P-loop; other site 272943001846 phosphorylation site [posttranslational modification] 272943001847 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 272943001848 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272943001849 active site 272943001850 P-loop; other site 272943001851 phosphorylation site [posttranslational modification] 272943001852 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 272943001853 hypothetical protein; Provisional; Region: PRK02237 272943001854 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 272943001855 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 272943001856 DNA binding residues [nucleotide binding] 272943001857 dimer interface [polypeptide binding]; other site 272943001858 putative metal binding site [ion binding]; other site 272943001859 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 272943001860 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272943001861 metal-binding site [ion binding] 272943001862 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 272943001863 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272943001864 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272943001865 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272943001866 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272943001867 dimer interface [polypeptide binding]; other site 272943001868 ssDNA binding site [nucleotide binding]; other site 272943001869 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272943001870 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272943001871 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943001872 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943001873 catalytic residue [active] 272943001874 seryl-tRNA synthetase; Provisional; Region: PRK05431 272943001875 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272943001876 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272943001877 dimer interface [polypeptide binding]; other site 272943001878 active site 272943001879 motif 1; other site 272943001880 motif 2; other site 272943001881 motif 3; other site 272943001882 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 272943001883 E-class dimer interface [polypeptide binding]; other site 272943001884 P-class dimer interface [polypeptide binding]; other site 272943001885 active site 272943001886 Cu2+ binding site [ion binding]; other site 272943001887 Zn2+ binding site [ion binding]; other site 272943001888 Preprotein translocase subunit; Region: YajC; pfam02699 272943001889 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 272943001890 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272943001891 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272943001892 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272943001893 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272943001894 Protein export membrane protein; Region: SecD_SecF; pfam02355 272943001895 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 272943001896 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 272943001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943001898 Walker A/P-loop; other site 272943001899 ATP binding site [chemical binding]; other site 272943001900 Q-loop/lid; other site 272943001901 ABC transporter signature motif; other site 272943001902 Walker B; other site 272943001903 D-loop; other site 272943001904 H-loop/switch region; other site 272943001905 heme exporter protein CcmB; Region: ccmB; TIGR01190 272943001906 heme exporter protein CcmC; Region: ccmC; TIGR01191 272943001907 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 272943001908 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 272943001909 catalytic residues [active] 272943001910 central insert; other site 272943001911 aconitate hydratase; Validated; Region: PRK09277 272943001912 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272943001913 substrate binding site [chemical binding]; other site 272943001914 ligand binding site [chemical binding]; other site 272943001915 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272943001916 substrate binding site [chemical binding]; other site 272943001917 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 272943001918 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272943001919 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272943001920 active site 272943001921 HIGH motif; other site 272943001922 dimer interface [polypeptide binding]; other site 272943001923 KMSKS motif; other site 272943001924 Rhomboid family; Region: Rhomboid; cl11446 272943001925 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272943001926 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272943001927 PII uridylyl-transferase; Provisional; Region: PRK05092 272943001928 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272943001929 metal binding triad; other site 272943001930 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272943001931 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272943001932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272943001933 Zn2+ binding site [ion binding]; other site 272943001934 Mg2+ binding site [ion binding]; other site 272943001935 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 272943001936 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 272943001937 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 272943001938 putative ligand binding site [chemical binding]; other site 272943001939 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272943001940 putative SAM binding site [chemical binding]; other site 272943001941 putative homodimer interface [polypeptide binding]; other site 272943001942 hypothetical protein; Provisional; Region: PRK14676 272943001943 glutathione synthetase; Provisional; Region: PRK05246 272943001944 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 272943001945 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 272943001946 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272943001947 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272943001948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943001949 Walker A motif; other site 272943001950 ATP binding site [chemical binding]; other site 272943001951 Walker B motif; other site 272943001952 arginine finger; other site 272943001953 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272943001954 FeoC like transcriptional regulator; Region: FeoC; pfam09012 272943001955 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 272943001956 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272943001957 G1 box; other site 272943001958 GTP/Mg2+ binding site [chemical binding]; other site 272943001959 Switch I region; other site 272943001960 G2 box; other site 272943001961 G3 box; other site 272943001962 Switch II region; other site 272943001963 G4 box; other site 272943001964 G5 box; other site 272943001965 Nucleoside recognition; Region: Gate; pfam07670 272943001966 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272943001967 Nucleoside recognition; Region: Gate; pfam07670 272943001968 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272943001969 FeoA domain; Region: FeoA; pfam04023 272943001970 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 272943001971 dimerization interface [polypeptide binding]; other site 272943001972 metal binding site [ion binding]; metal-binding site 272943001973 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272943001974 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 272943001975 putative molybdopterin cofactor binding site [chemical binding]; other site 272943001976 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 272943001977 putative molybdopterin cofactor binding site; other site 272943001978 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272943001979 homodimer interface [polypeptide binding]; other site 272943001980 NAD binding pocket [chemical binding]; other site 272943001981 ATP binding pocket [chemical binding]; other site 272943001982 Mg binding site [ion binding]; other site 272943001983 active-site loop [active] 272943001984 Competence-damaged protein; Region: CinA; pfam02464 272943001985 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272943001986 MPT binding site; other site 272943001987 trimer interface [polypeptide binding]; other site 272943001988 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 272943001989 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272943001990 NAD(P) binding site [chemical binding]; other site 272943001991 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 272943001992 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272943001993 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 272943001994 Cupredoxin superfamily; Region: Cupredoxin; cl19115 272943001995 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 272943001996 putative active site [active] 272943001997 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 272943001998 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 272943001999 Subunit III/VIIa interface [polypeptide binding]; other site 272943002000 Phospholipid binding site [chemical binding]; other site 272943002001 Subunit I/III interface [polypeptide binding]; other site 272943002002 Subunit III/VIb interface [polypeptide binding]; other site 272943002003 Subunit III/VIa interface; other site 272943002004 Subunit III/Vb interface [polypeptide binding]; other site 272943002005 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 272943002006 threonine synthase; Validated; Region: PRK09225 272943002007 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272943002008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943002009 catalytic residue [active] 272943002010 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272943002011 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272943002012 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272943002013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272943002014 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272943002015 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 272943002016 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 272943002017 FAD binding domain; Region: FAD_binding_4; pfam01565 272943002018 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272943002019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943002020 active site 272943002021 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 272943002022 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 272943002023 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272943002024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943002025 Coenzyme A binding pocket [chemical binding]; other site 272943002026 EcsC protein family; Region: EcsC; pfam12787 272943002027 Intracellular septation protein A; Region: IspA; pfam04279 272943002028 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 272943002029 EamA-like transporter family; Region: EamA; pfam00892 272943002030 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 272943002031 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272943002032 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272943002033 P loop; other site 272943002034 GTP binding site [chemical binding]; other site 272943002035 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272943002036 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272943002037 generic binding surface II; other site 272943002038 generic binding surface I; other site 272943002039 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; cl17501 272943002040 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 272943002041 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272943002042 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272943002043 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272943002044 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272943002045 pyruvate kinase; Validated; Region: PRK08187 272943002046 Pyruvate kinase, barrel domain; Region: PK; cl17342 272943002047 aspartate kinase; Reviewed; Region: PRK06635 272943002048 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272943002049 putative nucleotide binding site [chemical binding]; other site 272943002050 putative catalytic residues [active] 272943002051 putative Mg ion binding site [ion binding]; other site 272943002052 putative aspartate binding site [chemical binding]; other site 272943002053 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272943002054 putative allosteric regulatory site; other site 272943002055 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 272943002056 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 272943002057 GAF domain; Region: GAF; pfam01590 272943002058 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272943002059 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272943002060 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272943002061 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272943002062 homodimer interface [polypeptide binding]; other site 272943002063 substrate-cofactor binding pocket; other site 272943002064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943002065 catalytic residue [active] 272943002066 putative GTP cyclohydrolase; Provisional; Region: PRK13674 272943002067 Cation transport protein; Region: TrkH; cl17365 272943002068 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272943002069 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272943002070 Cation transport protein; Region: TrkH; cl17365 272943002071 Sporulation related domain; Region: SPOR; pfam05036 272943002072 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943002073 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272943002074 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272943002075 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272943002076 dimer interface [polypeptide binding]; other site 272943002077 motif 1; other site 272943002078 active site 272943002079 motif 2; other site 272943002080 motif 3; other site 272943002081 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272943002082 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272943002083 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272943002084 pyruvate phosphate dikinase; Provisional; Region: PRK09279 272943002085 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272943002086 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272943002087 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272943002088 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 272943002089 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272943002090 Dihydroneopterin aldolase; Region: FolB; smart00905 272943002091 active site 272943002092 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272943002093 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272943002094 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272943002095 substrate binding pocket [chemical binding]; other site 272943002096 dimer interface [polypeptide binding]; other site 272943002097 inhibitor binding site; inhibition site 272943002098 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 272943002099 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272943002100 active site 272943002101 substrate binding site [chemical binding]; other site 272943002102 metal binding site [ion binding]; metal-binding site 272943002103 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272943002104 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272943002105 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272943002106 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943002107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272943002108 putative DNA binding site [nucleotide binding]; other site 272943002109 putative Zn2+ binding site [ion binding]; other site 272943002110 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943002111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943002112 putative DNA binding site [nucleotide binding]; other site 272943002113 putative Zn2+ binding site [ion binding]; other site 272943002114 AsnC family; Region: AsnC_trans_reg; pfam01037 272943002115 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272943002116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943002117 catalytic residue [active] 272943002118 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 272943002119 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 272943002120 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272943002121 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272943002122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943002123 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272943002124 DNA-binding site [nucleotide binding]; DNA binding site 272943002125 FCD domain; Region: FCD; pfam07729 272943002126 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272943002127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943002128 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272943002129 active site 272943002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272943002131 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943002132 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272943002133 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272943002134 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272943002135 catalytic site [active] 272943002136 subunit interface [polypeptide binding]; other site 272943002137 Yqey-like protein; Region: YqeY; pfam09424 272943002138 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 272943002139 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 272943002140 Subunit I/III interface [polypeptide binding]; other site 272943002141 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272943002142 D-pathway; other site 272943002143 Subunit I/VIIc interface [polypeptide binding]; other site 272943002144 Subunit I/IV interface [polypeptide binding]; other site 272943002145 Subunit I/II interface [polypeptide binding]; other site 272943002146 Low-spin heme (heme a) binding site [chemical binding]; other site 272943002147 Subunit I/VIIa interface [polypeptide binding]; other site 272943002148 Subunit I/VIa interface [polypeptide binding]; other site 272943002149 Dimer interface; other site 272943002150 Putative water exit pathway; other site 272943002151 Binuclear center (heme a3/CuB) [ion binding]; other site 272943002152 K-pathway; other site 272943002153 Subunit I/Vb interface [polypeptide binding]; other site 272943002154 Putative proton exit pathway; other site 272943002155 Subunit I/VIb interface; other site 272943002156 Subunit I/VIc interface [polypeptide binding]; other site 272943002157 Electron transfer pathway; other site 272943002158 Subunit I/VIIIb interface [polypeptide binding]; other site 272943002159 Subunit I/VIIb interface [polypeptide binding]; other site 272943002160 lipoate-protein ligase B; Provisional; Region: PRK14341 272943002161 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943002162 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943002163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943002164 Walker A/P-loop; other site 272943002165 ATP binding site [chemical binding]; other site 272943002166 Q-loop/lid; other site 272943002167 ABC transporter signature motif; other site 272943002168 Walker B; other site 272943002169 D-loop; other site 272943002170 H-loop/switch region; other site 272943002171 TOBE domain; Region: TOBE_2; pfam08402 272943002172 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943002173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943002174 dimer interface [polypeptide binding]; other site 272943002175 conserved gate region; other site 272943002176 putative PBP binding loops; other site 272943002177 ABC-ATPase subunit interface; other site 272943002178 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943002179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943002180 dimer interface [polypeptide binding]; other site 272943002181 conserved gate region; other site 272943002182 putative PBP binding loops; other site 272943002183 ABC-ATPase subunit interface; other site 272943002184 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272943002185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272943002186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943002187 Coenzyme A binding pocket [chemical binding]; other site 272943002188 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272943002189 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 272943002190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943002191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943002192 dimerization interface [polypeptide binding]; other site 272943002193 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272943002194 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 272943002195 NAD(P) binding site [chemical binding]; other site 272943002196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943002197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943002198 non-specific DNA binding site [nucleotide binding]; other site 272943002199 salt bridge; other site 272943002200 sequence-specific DNA binding site [nucleotide binding]; other site 272943002201 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 272943002202 active site 272943002203 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272943002204 putative mechanosensitive channel protein; Provisional; Region: PRK11465 272943002205 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272943002206 guanine deaminase; Provisional; Region: PRK09228 272943002207 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 272943002208 active site 272943002209 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272943002210 MgtE intracellular N domain; Region: MgtE_N; smart00924 272943002211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272943002212 Divalent cation transporter; Region: MgtE; cl00786 272943002213 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272943002214 AAA ATPase domain; Region: AAA_16; pfam13191 272943002215 RNA helicase; Region: RNA_helicase; pfam00910 272943002216 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 272943002217 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 272943002218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272943002219 TPR motif; other site 272943002220 binding surface 272943002221 TPR repeat; Region: TPR_11; pfam13414 272943002222 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 272943002223 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 272943002224 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272943002225 ATP binding site [chemical binding]; other site 272943002226 Walker A motif; other site 272943002227 hexamer interface [polypeptide binding]; other site 272943002228 Walker B motif; other site 272943002229 Alphaherpesvirus glycoprotein E; Region: Herpes_gE; pfam02480 272943002230 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272943002231 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 272943002232 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943002233 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943002234 ligand binding site [chemical binding]; other site 272943002235 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 272943002236 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 272943002237 BON domain; Region: BON; pfam04972 272943002238 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272943002239 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272943002240 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272943002241 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943002242 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943002243 catalytic residue [active] 272943002244 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 272943002245 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 272943002246 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272943002247 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272943002248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943002249 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272943002250 dimerization interface [polypeptide binding]; other site 272943002251 substrate binding pocket [chemical binding]; other site 272943002252 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272943002253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943002254 Coenzyme A binding pocket [chemical binding]; other site 272943002255 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 272943002256 putative catalytic residue [active] 272943002257 Cupin domain; Region: Cupin_2; cl17218 272943002258 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 272943002259 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943002260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272943002261 AAA domain; Region: AAA_28; pfam13521 272943002262 Walker A/P-loop; other site 272943002263 ATP binding site [chemical binding]; other site 272943002264 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 272943002265 pyridoxal binding site [chemical binding]; other site 272943002266 dimer interface [polypeptide binding]; other site 272943002267 ATP binding site [chemical binding]; other site 272943002268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 272943002269 MOSC domain; Region: MOSC; pfam03473 272943002270 3-alpha domain; Region: 3-alpha; pfam03475 272943002271 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272943002272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943002273 DNA-binding site [nucleotide binding]; DNA binding site 272943002274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943002275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943002276 homodimer interface [polypeptide binding]; other site 272943002277 catalytic residue [active] 272943002278 biotin synthase; Region: bioB; TIGR00433 272943002279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943002280 FeS/SAM binding site; other site 272943002281 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272943002282 BioY family; Region: BioY; pfam02632 272943002283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943002284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943002285 DNA-binding site [nucleotide binding]; DNA binding site 272943002286 FCD domain; Region: FCD; pfam07729 272943002287 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 272943002288 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272943002289 FMN binding site [chemical binding]; other site 272943002290 active site 272943002291 catalytic residues [active] 272943002292 substrate binding site [chemical binding]; other site 272943002293 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943002294 replicative DNA helicase; Provisional; Region: PRK09165 272943002295 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272943002296 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272943002297 Walker A motif; other site 272943002298 ATP binding site [chemical binding]; other site 272943002299 Walker B motif; other site 272943002300 DNA binding loops [nucleotide binding] 272943002301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943002302 active site 272943002303 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 272943002304 active site 272943002305 substrate binding pocket [chemical binding]; other site 272943002306 dimer interface [polypeptide binding]; other site 272943002307 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 272943002308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943002309 Walker A motif; other site 272943002310 ATP binding site [chemical binding]; other site 272943002311 Walker B motif; other site 272943002312 arginine finger; other site 272943002313 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 272943002314 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272943002315 metal ion-dependent adhesion site (MIDAS); other site 272943002316 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 272943002317 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943002318 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943002319 ligand binding site [chemical binding]; other site 272943002320 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 272943002321 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 272943002322 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272943002323 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 272943002324 putative MPT binding site; other site 272943002325 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272943002326 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272943002327 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272943002328 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272943002329 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 272943002330 FAD binding pocket [chemical binding]; other site 272943002331 FAD binding motif [chemical binding]; other site 272943002332 phosphate binding motif [ion binding]; other site 272943002333 beta-alpha-beta structure motif; other site 272943002334 NAD binding pocket [chemical binding]; other site 272943002335 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 272943002336 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272943002337 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272943002338 Active Sites [active] 272943002339 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 272943002340 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272943002341 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 272943002342 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272943002343 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272943002344 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 272943002345 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272943002346 active site 272943002347 SAM binding site [chemical binding]; other site 272943002348 homodimer interface [polypeptide binding]; other site 272943002349 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943002350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943002351 putative DNA binding site [nucleotide binding]; other site 272943002352 putative Zn2+ binding site [ion binding]; other site 272943002353 AsnC family; Region: AsnC_trans_reg; pfam01037 272943002354 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272943002355 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272943002356 substrate binding site [chemical binding]; other site 272943002357 dimer interface [polypeptide binding]; other site 272943002358 catalytic triad [active] 272943002359 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272943002360 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 272943002361 Protein of unknown function (DUF982); Region: DUF982; pfam06169 272943002362 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943002363 DNA-binding site [nucleotide binding]; DNA binding site 272943002364 RNA-binding motif; other site 272943002365 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943002366 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943002367 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272943002368 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 272943002369 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272943002370 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272943002371 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943002372 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943002373 active site 272943002374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272943002375 Integrase core domain; Region: rve; pfam00665 272943002376 Integrase core domain; Region: rve_3; pfam13683 272943002377 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272943002378 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272943002379 active site 272943002380 catalytic residues [active] 272943002381 DNA binding site [nucleotide binding] 272943002382 Int/Topo IB signature motif; other site 272943002383 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272943002384 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272943002385 dimerization interface [polypeptide binding]; other site 272943002386 putative ATP binding site [chemical binding]; other site 272943002387 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272943002388 active site 272943002389 substrate binding site [chemical binding]; other site 272943002390 cosubstrate binding site; other site 272943002391 catalytic site [active] 272943002392 ribonuclease D; Region: rnd; TIGR01388 272943002393 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272943002394 catalytic site [active] 272943002395 putative active site [active] 272943002396 putative substrate binding site [chemical binding]; other site 272943002397 HRDC domain; Region: HRDC; pfam00570 272943002398 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 272943002399 Domain of unknown function (DUF427); Region: DUF427; pfam04248 272943002400 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272943002401 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272943002402 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 272943002403 active site 272943002404 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 272943002405 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 272943002406 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 272943002407 metal ion-dependent adhesion site (MIDAS); other site 272943002408 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 272943002409 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 272943002410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272943002411 Walker A motif; other site 272943002412 ATP binding site [chemical binding]; other site 272943002413 Walker B motif; other site 272943002414 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272943002415 HSP70 interaction site [polypeptide binding]; other site 272943002416 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 272943002417 malate synthase G; Provisional; Region: PRK02999 272943002418 active site 272943002419 aminopeptidase N; Provisional; Region: pepN; PRK14015 272943002420 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272943002421 Zn binding site [ion binding]; other site 272943002422 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 272943002423 putative acyl-acceptor binding pocket; other site 272943002424 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 272943002425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943002426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943002427 homodimer interface [polypeptide binding]; other site 272943002428 catalytic residue [active] 272943002429 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 272943002430 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272943002431 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272943002432 GatB domain; Region: GatB_Yqey; smart00845 272943002433 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 272943002434 catalytic residue [active] 272943002435 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 272943002436 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272943002437 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272943002438 active site 272943002439 HIGH motif; other site 272943002440 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272943002441 KMSKS motif; other site 272943002442 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272943002443 tRNA binding surface [nucleotide binding]; other site 272943002444 anticodon binding site; other site 272943002445 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272943002446 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943002447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272943002448 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272943002449 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 272943002450 dimer interface [polypeptide binding]; other site 272943002451 active site 272943002452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272943002453 catalytic residues [active] 272943002454 substrate binding site [chemical binding]; other site 272943002455 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 272943002456 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272943002457 CoenzymeA binding site [chemical binding]; other site 272943002458 subunit interaction site [polypeptide binding]; other site 272943002459 PHB binding site; other site 272943002460 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272943002461 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272943002462 dimer interface [polypeptide binding]; other site 272943002463 active site 272943002464 citrylCoA binding site [chemical binding]; other site 272943002465 NADH binding [chemical binding]; other site 272943002466 cationic pore residues; other site 272943002467 oxalacetate/citrate binding site [chemical binding]; other site 272943002468 coenzyme A binding site [chemical binding]; other site 272943002469 catalytic triad [active] 272943002470 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272943002471 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272943002472 active site 272943002473 HIGH motif; other site 272943002474 KMSKS motif; other site 272943002475 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272943002476 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272943002477 Competence protein; Region: Competence; pfam03772 272943002478 LexA repressor; Validated; Region: PRK00215 272943002479 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 272943002480 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272943002481 Catalytic site [active] 272943002482 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272943002483 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272943002484 dimer interface [polypeptide binding]; other site 272943002485 putative functional site; other site 272943002486 putative MPT binding site; other site 272943002487 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272943002488 trimer interface [polypeptide binding]; other site 272943002489 dimer interface [polypeptide binding]; other site 272943002490 putative active site [active] 272943002491 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272943002492 active site 272943002493 ribulose/triose binding site [chemical binding]; other site 272943002494 phosphate binding site [ion binding]; other site 272943002495 substrate (anthranilate) binding pocket [chemical binding]; other site 272943002496 product (indole) binding pocket [chemical binding]; other site 272943002497 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272943002498 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272943002499 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272943002500 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272943002501 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272943002502 glutamine binding [chemical binding]; other site 272943002503 catalytic triad [active] 272943002504 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 272943002505 NodB motif; other site 272943002506 putative active site [active] 272943002507 putative catalytic site [active] 272943002508 Zn binding site [ion binding]; other site 272943002509 anthranilate synthase component I; Provisional; Region: PRK13573 272943002510 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272943002511 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272943002512 SurA N-terminal domain; Region: SurA_N_3; cl07813 272943002513 periplasmic folding chaperone; Provisional; Region: PRK10788 272943002514 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 272943002515 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 272943002516 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 272943002517 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272943002518 GcrA cell cycle regulator; Region: GcrA; cl11564 272943002519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943002520 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943002521 inhibitor-cofactor binding pocket; inhibition site 272943002522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943002523 catalytic residue [active] 272943002524 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272943002525 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272943002526 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272943002527 transcription elongation factor regulatory protein; Validated; Region: PRK06342 272943002528 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272943002529 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272943002530 nudix motif; other site 272943002531 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 272943002532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943002533 ATP binding site [chemical binding]; other site 272943002534 putative Mg++ binding site [ion binding]; other site 272943002535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943002536 nucleotide binding region [chemical binding]; other site 272943002537 ATP-binding site [chemical binding]; other site 272943002538 Helicase associated domain (HA2); Region: HA2; pfam04408 272943002539 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 272943002540 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 272943002541 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 272943002542 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 272943002543 Walker A; other site 272943002544 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272943002545 Protein of unknown function (DUF461); Region: DUF461; pfam04314 272943002546 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 272943002547 Dihaem cytochrome c; Region: DHC; pfam09626 272943002548 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 272943002549 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272943002550 Dihaem cytochrome c; Region: DHC; pfam09626 272943002551 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943002552 DNA-binding site [nucleotide binding]; DNA binding site 272943002553 RNA-binding motif; other site 272943002554 Helix-turn-helix domain; Region: HTH_18; pfam12833 272943002555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943002556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943002557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943002558 dimerization interface [polypeptide binding]; other site 272943002559 SnoaL-like domain; Region: SnoaL_2; pfam12680 272943002560 short chain dehydrogenase; Provisional; Region: PRK06523 272943002561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943002562 NAD(P) binding site [chemical binding]; other site 272943002563 active site 272943002564 PAS fold; Region: PAS_4; pfam08448 272943002565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943002566 HWE histidine kinase; Region: HWE_HK; smart00911 272943002567 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272943002568 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 272943002569 CAAX protease self-immunity; Region: Abi; pfam02517 272943002570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272943002571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943002572 Coenzyme A binding pocket [chemical binding]; other site 272943002573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943002574 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943002575 classical (c) SDRs; Region: SDR_c; cd05233 272943002576 NAD(P) binding site [chemical binding]; other site 272943002577 active site 272943002578 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 272943002579 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 272943002580 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 272943002581 metal binding triad [ion binding]; metal-binding site 272943002582 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 272943002583 ThiF family; Region: ThiF; pfam00899 272943002584 ATP binding site [chemical binding]; other site 272943002585 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 272943002586 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943002587 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 272943002588 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272943002589 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943002590 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 272943002591 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272943002592 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 272943002593 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272943002594 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272943002595 oligomerization interface [polypeptide binding]; other site 272943002596 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 272943002597 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272943002598 Phage capsid family; Region: Phage_capsid; pfam05065 272943002599 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 272943002600 oligomer interface [polypeptide binding]; other site 272943002601 active site residues [active] 272943002602 Phage portal protein; Region: Phage_portal; pfam04860 272943002603 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272943002604 Phage Terminase; Region: Terminase_1; cl19862 272943002605 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943002606 active site 272943002607 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943002608 AAA domain; Region: AAA_33; pfam13671 272943002609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943002610 Walker A/P-loop; other site 272943002611 ATP binding site [chemical binding]; other site 272943002612 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 272943002613 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943002614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943002615 non-specific DNA binding site [nucleotide binding]; other site 272943002616 salt bridge; other site 272943002617 sequence-specific DNA binding site [nucleotide binding]; other site 272943002618 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272943002619 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272943002620 ParB-like nuclease domain; Region: ParBc; pfam02195 272943002621 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272943002622 DNA binding residues [nucleotide binding] 272943002623 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272943002624 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272943002625 active site 272943002626 catalytic residues [active] 272943002627 DNA binding site [nucleotide binding] 272943002628 Int/Topo IB signature motif; other site 272943002629 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272943002630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943002631 Coenzyme A binding pocket [chemical binding]; other site 272943002632 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 272943002633 excinuclease ABC subunit B; Provisional; Region: PRK05298 272943002634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943002635 ATP binding site [chemical binding]; other site 272943002636 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 272943002637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943002638 nucleotide binding region [chemical binding]; other site 272943002639 ATP-binding site [chemical binding]; other site 272943002640 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272943002641 UvrB/uvrC motif; Region: UVR; pfam02151 272943002642 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 272943002643 GTP-binding protein LepA; Provisional; Region: PRK05433 272943002644 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272943002645 G1 box; other site 272943002646 putative GEF interaction site [polypeptide binding]; other site 272943002647 GTP/Mg2+ binding site [chemical binding]; other site 272943002648 Switch I region; other site 272943002649 G2 box; other site 272943002650 G3 box; other site 272943002651 Switch II region; other site 272943002652 G4 box; other site 272943002653 G5 box; other site 272943002654 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272943002655 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272943002656 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272943002657 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272943002658 pyruvate carboxylase; Reviewed; Region: PRK12999 272943002659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272943002660 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272943002661 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272943002662 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272943002663 active site 272943002664 catalytic residues [active] 272943002665 metal binding site [ion binding]; metal-binding site 272943002666 homodimer binding site [polypeptide binding]; other site 272943002667 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 272943002668 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272943002669 carboxyltransferase (CT) interaction site; other site 272943002670 biotinylation site [posttranslational modification]; other site 272943002671 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272943002672 Part of AAA domain; Region: AAA_19; pfam13245 272943002673 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272943002674 Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown]; Region: COG1747 272943002675 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 272943002676 Sulfate transporter family; Region: Sulfate_transp; cl19250 272943002677 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 272943002678 Domain of unknown function DUF59; Region: DUF59; pfam01883 272943002679 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 272943002680 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272943002681 cell division protein MraZ; Reviewed; Region: PRK00326 272943002682 MraZ protein; Region: MraZ; pfam02381 272943002683 MraZ protein; Region: MraZ; pfam02381 272943002684 MraW methylase family; Region: Methyltransf_5; cl17771 272943002685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943002686 S-adenosylmethionine binding site [chemical binding]; other site 272943002687 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 272943002688 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272943002689 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272943002690 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272943002691 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272943002692 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272943002693 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272943002694 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272943002695 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 272943002696 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272943002697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272943002698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272943002699 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272943002700 Mg++ binding site [ion binding]; other site 272943002701 putative catalytic motif [active] 272943002702 putative substrate binding site [chemical binding]; other site 272943002703 BON domain; Region: BON; pfam04972 272943002704 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 272943002705 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272943002706 NAD binding site [chemical binding]; other site 272943002707 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272943002708 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272943002709 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272943002710 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272943002711 hydrophobic ligand binding site; other site 272943002712 cell division protein FtsW; Region: ftsW; TIGR02614 272943002713 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272943002714 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272943002715 active site 272943002716 homodimer interface [polypeptide binding]; other site 272943002717 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272943002718 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272943002719 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272943002720 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272943002721 Protein of unknown function (DUF2484); Region: DUF2484; pfam10658 272943002722 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272943002723 FAD binding domain; Region: FAD_binding_4; cl19922 272943002724 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272943002725 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 272943002726 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272943002727 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272943002728 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272943002729 Cell division protein FtsQ; Region: FtsQ; pfam03799 272943002730 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272943002731 Cell division protein FtsA; Region: FtsA; smart00842 272943002732 Cell division protein FtsA; Region: FtsA; pfam14450 272943002733 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 272943002734 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272943002735 nucleotide binding site [chemical binding]; other site 272943002736 SulA interaction site; other site 272943002737 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 272943002738 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272943002739 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 272943002740 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272943002741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272943002742 Walker A/P-loop; other site 272943002743 ATP binding site [chemical binding]; other site 272943002744 Q-loop/lid; other site 272943002745 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272943002746 ABC transporter signature motif; other site 272943002747 Walker B; other site 272943002748 D-loop; other site 272943002749 H-loop/switch region; other site 272943002750 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 272943002751 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272943002752 FAD binding domain; Region: FAD_binding_4; pfam01565 272943002753 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272943002754 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 272943002755 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 272943002756 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 272943002757 B12 binding site [chemical binding]; other site 272943002758 cobalt ligand [ion binding]; other site 272943002759 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272943002760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943002761 FeS/SAM binding site; other site 272943002762 methionine synthase I; Validated; Region: PRK07534 272943002763 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 272943002764 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272943002765 ATP binding site [chemical binding]; other site 272943002766 active site 272943002767 substrate binding site [chemical binding]; other site 272943002768 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 272943002769 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272943002770 putative active site [active] 272943002771 catalytic triad [active] 272943002772 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 272943002773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943002774 dimer interface [polypeptide binding]; other site 272943002775 phosphorylation site [posttranslational modification] 272943002776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943002777 ATP binding site [chemical binding]; other site 272943002778 Mg2+ binding site [ion binding]; other site 272943002779 G-X-G motif; other site 272943002780 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272943002781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943002782 active site 272943002783 phosphorylation site [posttranslational modification] 272943002784 intermolecular recognition site; other site 272943002785 dimerization interface [polypeptide binding]; other site 272943002786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943002787 Walker A motif; other site 272943002788 ATP binding site [chemical binding]; other site 272943002789 Walker B motif; other site 272943002790 arginine finger; other site 272943002791 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943002792 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 272943002793 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272943002794 homodimer interface [polypeptide binding]; other site 272943002795 oligonucleotide binding site [chemical binding]; other site 272943002796 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272943002797 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 272943002798 CPxP motif; other site 272943002799 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272943002800 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272943002801 nucleophilic elbow; other site 272943002802 catalytic triad; other site 272943002803 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 272943002804 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 272943002805 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272943002806 Class II fumarases; Region: Fumarase_classII; cd01362 272943002807 active site 272943002808 tetramer interface [polypeptide binding]; other site 272943002809 Stringent starvation protein B; Region: SspB; pfam04386 272943002810 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 272943002811 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943002812 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943002813 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943002814 catalytic residue [active] 272943002815 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 272943002816 DNA photolyase; Region: DNA_photolyase; pfam00875 272943002817 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 272943002818 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272943002819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272943002820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943002821 S-adenosylmethionine binding site [chemical binding]; other site 272943002822 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272943002823 putative active site pocket [active] 272943002824 putative catalytic residue [active] 272943002825 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 272943002826 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272943002827 dimer interface [polypeptide binding]; other site 272943002828 ADP-ribose binding site [chemical binding]; other site 272943002829 active site 272943002830 nudix motif; other site 272943002831 metal binding site [ion binding]; metal-binding site 272943002832 cysteine synthase; Region: PLN02565 272943002833 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272943002834 dimer interface [polypeptide binding]; other site 272943002835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943002836 catalytic residue [active] 272943002837 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 272943002838 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 272943002839 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272943002840 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 272943002841 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272943002842 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272943002843 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943002844 active site 272943002845 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272943002846 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943002847 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272943002848 active site 272943002849 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 272943002850 putative active site [active] 272943002851 putative metal binding site [ion binding]; other site 272943002852 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272943002853 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272943002854 NAD binding site [chemical binding]; other site 272943002855 dimerization interface [polypeptide binding]; other site 272943002856 product binding site; other site 272943002857 substrate binding site [chemical binding]; other site 272943002858 zinc binding site [ion binding]; other site 272943002859 catalytic residues [active] 272943002860 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943002861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943002862 dimer interface [polypeptide binding]; other site 272943002863 conserved gate region; other site 272943002864 putative PBP binding loops; other site 272943002865 ABC-ATPase subunit interface; other site 272943002866 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272943002867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943002868 dimer interface [polypeptide binding]; other site 272943002869 conserved gate region; other site 272943002870 putative PBP binding loops; other site 272943002871 ABC-ATPase subunit interface; other site 272943002872 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272943002873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943002874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943002875 Walker A/P-loop; other site 272943002876 ATP binding site [chemical binding]; other site 272943002877 Q-loop/lid; other site 272943002878 ABC transporter signature motif; other site 272943002879 Walker B; other site 272943002880 D-loop; other site 272943002881 H-loop/switch region; other site 272943002882 TOBE domain; Region: TOBE_2; pfam08402 272943002883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943002884 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272943002885 NAD(P) binding site [chemical binding]; other site 272943002886 active site 272943002887 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272943002888 active site 272943002889 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 272943002890 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272943002891 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943002892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943002893 dimerization interface [polypeptide binding]; other site 272943002894 putative Zn2+ binding site [ion binding]; other site 272943002895 putative DNA binding site [nucleotide binding]; other site 272943002896 AsnC family; Region: AsnC_trans_reg; pfam01037 272943002897 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 272943002898 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 272943002899 Proline dehydrogenase; Region: Pro_dh; pfam01619 272943002900 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 272943002901 Glutamate binding site [chemical binding]; other site 272943002902 NAD binding site [chemical binding]; other site 272943002903 catalytic residues [active] 272943002904 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 272943002905 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272943002906 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272943002907 active site 272943002908 dimerization interface [polypeptide binding]; other site 272943002909 Phosphate transporter family; Region: PHO4; pfam01384 272943002910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943002911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943002912 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 272943002913 putative dimerization interface [polypeptide binding]; other site 272943002914 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272943002915 FAD binding site [chemical binding]; other site 272943002916 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 272943002917 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272943002918 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272943002919 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272943002920 Walker A/P-loop; other site 272943002921 ATP binding site [chemical binding]; other site 272943002922 Q-loop/lid; other site 272943002923 ABC transporter signature motif; other site 272943002924 Walker B; other site 272943002925 D-loop; other site 272943002926 H-loop/switch region; other site 272943002927 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272943002928 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272943002929 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 272943002930 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272943002931 active site 272943002932 interdomain interaction site; other site 272943002933 putative metal-binding site [ion binding]; other site 272943002934 nucleotide binding site [chemical binding]; other site 272943002935 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272943002936 domain I; other site 272943002937 DNA binding groove [nucleotide binding] 272943002938 phosphate binding site [ion binding]; other site 272943002939 domain II; other site 272943002940 domain III; other site 272943002941 nucleotide binding site [chemical binding]; other site 272943002942 catalytic site [active] 272943002943 domain IV; other site 272943002944 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272943002945 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272943002946 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272943002947 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272943002948 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 272943002949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943002950 Walker A/P-loop; other site 272943002951 ATP binding site [chemical binding]; other site 272943002952 Q-loop/lid; other site 272943002953 ABC transporter signature motif; other site 272943002954 Walker B; other site 272943002955 D-loop; other site 272943002956 H-loop/switch region; other site 272943002957 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943002958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943002959 dimer interface [polypeptide binding]; other site 272943002960 conserved gate region; other site 272943002961 putative PBP binding loops; other site 272943002962 ABC-ATPase subunit interface; other site 272943002963 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 272943002964 transcriptional regulator BetI; Validated; Region: PRK00767 272943002965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943002966 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272943002967 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 272943002968 NAD(P) binding site [chemical binding]; other site 272943002969 catalytic residues [active] 272943002970 choline dehydrogenase; Validated; Region: PRK02106 272943002971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943002972 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 272943002973 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272943002974 Staphylococcal nuclease homologues; Region: SNc; smart00318 272943002975 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 272943002976 Catalytic site; other site 272943002977 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943002978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943002979 non-specific DNA binding site [nucleotide binding]; other site 272943002980 salt bridge; other site 272943002981 sequence-specific DNA binding site [nucleotide binding]; other site 272943002982 Uncharacterized protein family UPF0449; Region: UPF0449; pfam15136 272943002983 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 272943002984 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272943002985 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 272943002986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943002987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943002988 putative substrate translocation pore; other site 272943002989 Protein of unknown function, DUF486; Region: DUF486; cl01236 272943002990 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272943002991 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272943002992 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272943002993 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 272943002994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272943002995 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272943002996 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272943002997 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272943002998 carboxyltransferase (CT) interaction site; other site 272943002999 biotinylation site [posttranslational modification]; other site 272943003000 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 272943003001 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 272943003002 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 272943003003 active site 272943003004 substrate binding site [chemical binding]; other site 272943003005 coenzyme B12 binding site [chemical binding]; other site 272943003006 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272943003007 B12 binding site [chemical binding]; other site 272943003008 cobalt ligand [ion binding]; other site 272943003009 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 272943003010 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 272943003011 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272943003012 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272943003013 lipoyl attachment site [posttranslational modification]; other site 272943003014 glycine dehydrogenase; Provisional; Region: PRK05367 272943003015 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272943003016 tetramer interface [polypeptide binding]; other site 272943003017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003018 catalytic residue [active] 272943003019 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272943003020 tetramer interface [polypeptide binding]; other site 272943003021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003022 catalytic residue [active] 272943003023 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 272943003024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943003025 substrate binding site [chemical binding]; other site 272943003026 oxyanion hole (OAH) forming residues; other site 272943003027 trimer interface [polypeptide binding]; other site 272943003028 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272943003029 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272943003030 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272943003031 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 272943003032 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272943003033 dimer interface [polypeptide binding]; other site 272943003034 active site 272943003035 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272943003036 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 272943003037 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 272943003038 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272943003039 active site 272943003040 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 272943003041 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 272943003042 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272943003043 DNA binding residues [nucleotide binding] 272943003044 putative dimer interface [polypeptide binding]; other site 272943003045 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 272943003046 DNA binding residues [nucleotide binding] 272943003047 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 272943003048 putative dimer interface [polypeptide binding]; other site 272943003049 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272943003050 CoenzymeA binding site [chemical binding]; other site 272943003051 subunit interaction site [polypeptide binding]; other site 272943003052 PHB binding site; other site 272943003053 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272943003054 CoenzymeA binding site [chemical binding]; other site 272943003055 subunit interaction site [polypeptide binding]; other site 272943003056 PHB binding site; other site 272943003057 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 272943003058 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 272943003059 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 272943003060 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 272943003061 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943003062 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272943003063 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 272943003064 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272943003065 TM-ABC transporter signature motif; other site 272943003066 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272943003067 TM-ABC transporter signature motif; other site 272943003068 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272943003069 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943003070 Walker A/P-loop; other site 272943003071 ATP binding site [chemical binding]; other site 272943003072 Q-loop/lid; other site 272943003073 ABC transporter signature motif; other site 272943003074 Walker B; other site 272943003075 D-loop; other site 272943003076 H-loop/switch region; other site 272943003077 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272943003078 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272943003079 ligand binding site [chemical binding]; other site 272943003080 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272943003081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272943003082 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272943003083 Glycoprotease family; Region: Peptidase_M22; pfam00814 272943003084 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 272943003085 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272943003086 aminotransferase; Provisional; Region: PRK13356 272943003087 homodimer interface [polypeptide binding]; other site 272943003088 substrate-cofactor binding pocket; other site 272943003089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003090 catalytic residue [active] 272943003091 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 272943003092 putative metal binding site [ion binding]; other site 272943003093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272943003094 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943003095 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272943003096 putative acyl-acceptor binding pocket; other site 272943003097 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272943003098 FliG N-terminal domain; Region: FliG_N; pfam14842 272943003099 FliG middle domain; Region: FliG_M; pfam14841 272943003100 FliG C-terminal domain; Region: FliG_C; pfam01706 272943003101 adenylosuccinate lyase; Provisional; Region: PRK07492 272943003102 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272943003103 tetramer interface [polypeptide binding]; other site 272943003104 active site 272943003105 Domain of unknown function (DUF333); Region: DUF333; pfam03891 272943003106 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272943003107 MMPL family; Region: MMPL; cl14618 272943003108 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272943003109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272943003110 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943003111 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 272943003112 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272943003113 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272943003114 active site 272943003115 catalytic site [active] 272943003116 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 272943003117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943003118 active site 272943003119 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272943003120 putative trimer interface [polypeptide binding]; other site 272943003121 putative CoA binding site [chemical binding]; other site 272943003122 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 272943003123 CheB methylesterase; Region: CheB_methylest; pfam01339 272943003124 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272943003125 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272943003126 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272943003127 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cd00179 272943003128 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272943003129 nSec1 interaction sites; other site 272943003130 interdomain interaction site; other site 272943003131 PAS domain; Region: PAS_10; pfam13596 272943003132 linker region; other site 272943003133 PAS fold; Region: PAS_4; pfam08448 272943003134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943003135 putative active site [active] 272943003136 heme pocket [chemical binding]; other site 272943003137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943003138 HWE histidine kinase; Region: HWE_HK; pfam07536 272943003139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003140 active site 272943003141 phosphorylation site [posttranslational modification] 272943003142 intermolecular recognition site; other site 272943003143 dimerization interface [polypeptide binding]; other site 272943003144 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 272943003145 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 272943003146 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272943003147 Fe-S cluster binding site [ion binding]; other site 272943003148 active site 272943003149 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 272943003150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943003151 FeS/SAM binding site; other site 272943003152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 272943003153 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272943003154 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943003155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272943003156 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272943003157 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272943003158 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943003159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943003160 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943003161 putative substrate translocation pore; other site 272943003162 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272943003163 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272943003164 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272943003165 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272943003166 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272943003167 metal binding site [ion binding]; metal-binding site 272943003168 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272943003169 substrate binding site [chemical binding]; other site 272943003170 glutamase interaction surface [polypeptide binding]; other site 272943003171 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272943003172 catalytic residues [active] 272943003173 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 272943003174 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 272943003175 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272943003176 putative active site [active] 272943003177 oxyanion strand; other site 272943003178 catalytic triad [active] 272943003179 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272943003180 putative active site pocket [active] 272943003181 4-fold oligomerization interface [polypeptide binding]; other site 272943003182 metal binding residues [ion binding]; metal-binding site 272943003183 3-fold/trimer interface [polypeptide binding]; other site 272943003184 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 272943003185 elongation factor G; Reviewed; Region: PRK12740 272943003186 G1 box; other site 272943003187 putative GEF interaction site [polypeptide binding]; other site 272943003188 GTP/Mg2+ binding site [chemical binding]; other site 272943003189 Switch I region; other site 272943003190 G2 box; other site 272943003191 G3 box; other site 272943003192 Switch II region; other site 272943003193 G4 box; other site 272943003194 G5 box; other site 272943003195 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272943003196 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272943003197 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272943003198 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272943003199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943003200 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943003201 putative substrate translocation pore; other site 272943003202 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943003203 Probable pheophorbidase; Region: PLN02965; cl17657 272943003204 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 272943003205 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943003206 TAP-like protein; Region: Abhydrolase_4; pfam08386 272943003207 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272943003208 tetramer interface [polypeptide binding]; other site 272943003209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003210 catalytic residue [active] 272943003211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943003212 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943003213 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 272943003214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943003215 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 272943003216 Walker A/P-loop; other site 272943003217 ATP binding site [chemical binding]; other site 272943003218 Q-loop/lid; other site 272943003219 ABC transporter signature motif; other site 272943003220 Walker B; other site 272943003221 D-loop; other site 272943003222 H-loop/switch region; other site 272943003223 AMP-binding domain protein; Validated; Region: PRK07529 272943003224 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272943003225 acyl-activating enzyme (AAE) consensus motif; other site 272943003226 AMP binding site [chemical binding]; other site 272943003227 active site 272943003228 CoA binding site [chemical binding]; other site 272943003229 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 272943003230 putative active site [active] 272943003231 dimerization interface [polypeptide binding]; other site 272943003232 putative tRNAtyr binding site [nucleotide binding]; other site 272943003233 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 272943003234 putative substrate binding site [chemical binding]; other site 272943003235 putative ATP binding site [chemical binding]; other site 272943003236 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 272943003237 active site 272943003238 ATP binding site [chemical binding]; other site 272943003239 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 272943003240 substrate binding site [chemical binding]; other site 272943003241 Predicted membrane protein [Function unknown]; Region: COG1238 272943003242 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 272943003243 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 272943003244 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 272943003245 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 272943003246 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272943003247 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 272943003248 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272943003249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272943003250 RNA binding surface [nucleotide binding]; other site 272943003251 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272943003252 active site 272943003253 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272943003254 nucleoside/Zn binding site; other site 272943003255 dimer interface [polypeptide binding]; other site 272943003256 catalytic motif [active] 272943003257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272943003258 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272943003259 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272943003260 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 272943003261 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272943003262 amidase catalytic site [active] 272943003263 Zn binding residues [ion binding]; other site 272943003264 substrate binding site [chemical binding]; other site 272943003265 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272943003266 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 272943003267 acyl-activating enzyme (AAE) consensus motif; other site 272943003268 active site 272943003269 AMP binding site [chemical binding]; other site 272943003270 CoA binding site [chemical binding]; other site 272943003271 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272943003272 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272943003273 Walker A/P-loop; other site 272943003274 ATP binding site [chemical binding]; other site 272943003275 Q-loop/lid; other site 272943003276 ABC transporter signature motif; other site 272943003277 Walker B; other site 272943003278 D-loop; other site 272943003279 H-loop/switch region; other site 272943003280 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 272943003281 putative ligand binding site [chemical binding]; other site 272943003282 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272943003283 TM-ABC transporter signature motif; other site 272943003284 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272943003285 TM-ABC transporter signature motif; other site 272943003286 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943003287 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272943003288 Walker A/P-loop; other site 272943003289 ATP binding site [chemical binding]; other site 272943003290 Q-loop/lid; other site 272943003291 ABC transporter signature motif; other site 272943003292 Walker B; other site 272943003293 D-loop; other site 272943003294 H-loop/switch region; other site 272943003295 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 272943003296 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 272943003297 acyl-activating enzyme (AAE) consensus motif; other site 272943003298 putative AMP binding site [chemical binding]; other site 272943003299 putative active site [active] 272943003300 putative CoA binding site [chemical binding]; other site 272943003301 PAS fold; Region: PAS_7; pfam12860 272943003302 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 272943003303 PAS domain; Region: PAS_10; pfam13596 272943003304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943003305 ATP binding site [chemical binding]; other site 272943003306 Mg2+ binding site [ion binding]; other site 272943003307 G-X-G motif; other site 272943003308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003309 active site 272943003310 phosphorylation site [posttranslational modification] 272943003311 intermolecular recognition site; other site 272943003312 dimerization interface [polypeptide binding]; other site 272943003313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943003314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003315 active site 272943003316 phosphorylation site [posttranslational modification] 272943003317 intermolecular recognition site; other site 272943003318 dimerization interface [polypeptide binding]; other site 272943003319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943003320 DNA binding site [nucleotide binding] 272943003321 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272943003322 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 272943003323 Chromate transporter; Region: Chromate_transp; pfam02417 272943003324 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272943003325 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272943003326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272943003327 RNA binding surface [nucleotide binding]; other site 272943003328 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 272943003329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943003330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003331 homodimer interface [polypeptide binding]; other site 272943003332 catalytic residue [active] 272943003333 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 272943003334 prephenate dehydrogenase; Validated; Region: PRK08507 272943003335 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 272943003336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 272943003337 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 272943003338 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 272943003339 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272943003340 putative active site pocket [active] 272943003341 dimerization interface [polypeptide binding]; other site 272943003342 putative catalytic residue [active] 272943003343 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 272943003344 hypothetical protein; Validated; Region: PRK09039 272943003345 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943003346 ligand binding site [chemical binding]; other site 272943003347 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 272943003348 Clp amino terminal domain; Region: Clp_N; pfam02861 272943003349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943003350 Walker A motif; other site 272943003351 ATP binding site [chemical binding]; other site 272943003352 Walker B motif; other site 272943003353 arginine finger; other site 272943003354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943003355 Walker A motif; other site 272943003356 ATP binding site [chemical binding]; other site 272943003357 Walker B motif; other site 272943003358 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272943003359 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 272943003360 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272943003361 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272943003362 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272943003363 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272943003364 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272943003365 beta subunit interaction interface [polypeptide binding]; other site 272943003366 Walker A motif; other site 272943003367 ATP binding site [chemical binding]; other site 272943003368 Walker B motif; other site 272943003369 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272943003370 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272943003371 core domain interface [polypeptide binding]; other site 272943003372 delta subunit interface [polypeptide binding]; other site 272943003373 epsilon subunit interface [polypeptide binding]; other site 272943003374 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272943003375 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272943003376 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272943003377 alpha subunit interaction interface [polypeptide binding]; other site 272943003378 Walker A motif; other site 272943003379 ATP binding site [chemical binding]; other site 272943003380 Walker B motif; other site 272943003381 inhibitor binding site; inhibition site 272943003382 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272943003383 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443 272943003384 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272943003385 gamma subunit interface [polypeptide binding]; other site 272943003386 epsilon subunit interface [polypeptide binding]; other site 272943003387 LBP interface [polypeptide binding]; other site 272943003388 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272943003389 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272943003390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943003391 active site 272943003392 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943003393 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272943003394 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943003395 catalytic residue [active] 272943003396 hypothetical protein; Provisional; Region: PRK05170 272943003397 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272943003398 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272943003399 active site 272943003400 Riboflavin kinase; Region: Flavokinase; smart00904 272943003401 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 272943003402 dimer interaction site [polypeptide binding]; other site 272943003403 substrate-binding tunnel; other site 272943003404 active site 272943003405 catalytic site [active] 272943003406 substrate binding site [chemical binding]; other site 272943003407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943003408 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 272943003409 active site 272943003410 motif I; other site 272943003411 motif II; other site 272943003412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943003413 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272943003414 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272943003415 DHHA2 domain; Region: DHHA2; pfam02833 272943003416 TraB family; Region: TraB; pfam01963 272943003417 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272943003418 oligomerisation interface [polypeptide binding]; other site 272943003419 mobile loop; other site 272943003420 roof hairpin; other site 272943003421 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272943003422 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272943003423 ring oligomerisation interface [polypeptide binding]; other site 272943003424 ATP/Mg binding site [chemical binding]; other site 272943003425 stacking interactions; other site 272943003426 hinge regions; other site 272943003427 Bacterial SH3 domain; Region: SH3_4; pfam06347 272943003428 Bacterial SH3 domain; Region: SH3_4; pfam06347 272943003429 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272943003430 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 272943003431 dimerization interface [polypeptide binding]; other site 272943003432 ligand binding site [chemical binding]; other site 272943003433 NADP binding site [chemical binding]; other site 272943003434 catalytic site [active] 272943003435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272943003436 active site 272943003437 catalytic tetrad [active] 272943003438 FAD dependent oxidoreductase; Region: DAO; pfam01266 272943003439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943003440 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 272943003441 putative active site [active] 272943003442 metal binding site [ion binding]; metal-binding site 272943003443 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 272943003444 NAD(P) binding site [chemical binding]; other site 272943003445 catalytic residues [active] 272943003446 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272943003447 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272943003448 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 272943003449 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272943003450 DctM-like transporters; Region: DctM; pfam06808 272943003451 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 272943003452 N-formylglutamate amidohydrolase; Region: FGase; cl01522 272943003453 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272943003454 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272943003455 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272943003456 putative active site [active] 272943003457 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272943003458 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272943003459 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272943003460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272943003461 rod shape-determining protein MreC; Provisional; Region: PRK13922 272943003462 rod shape-determining protein MreB; Provisional; Region: PRK13927 272943003463 MreB and similar proteins; Region: MreB_like; cd10225 272943003464 nucleotide binding site [chemical binding]; other site 272943003465 Mg binding site [ion binding]; other site 272943003466 putative protofilament interaction site [polypeptide binding]; other site 272943003467 RodZ interaction site [polypeptide binding]; other site 272943003468 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272943003469 2-isopropylmalate synthase; Validated; Region: PRK00915 272943003470 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272943003471 active site 272943003472 catalytic residues [active] 272943003473 metal binding site [ion binding]; metal-binding site 272943003474 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272943003475 Pseudoazurin (Paz) is a type I blue copper electron-transfer protein; Region: Pseudoazurin; cd04218 272943003476 Type 1 (T1) Cu binding site [ion binding]; other site 272943003477 MORN repeat; Region: MORN; cl14787 272943003478 MORN repeat; Region: MORN; cl14787 272943003479 MORN repeat; Region: MORN; cl14787 272943003480 NAD synthetase; Provisional; Region: PRK13981 272943003481 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272943003482 multimer interface [polypeptide binding]; other site 272943003483 active site 272943003484 catalytic triad [active] 272943003485 protein interface 1 [polypeptide binding]; other site 272943003486 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272943003487 homodimer interface [polypeptide binding]; other site 272943003488 NAD binding pocket [chemical binding]; other site 272943003489 ATP binding pocket [chemical binding]; other site 272943003490 Mg binding site [ion binding]; other site 272943003491 active-site loop [active] 272943003492 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272943003493 putative substrate binding site [chemical binding]; other site 272943003494 putative ATP binding site [chemical binding]; other site 272943003495 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272943003496 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 272943003497 Peptidase family M48; Region: Peptidase_M48; cl12018 272943003498 PRC-barrel domain; Region: PRC; pfam05239 272943003499 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 272943003500 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272943003501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943003502 FeS/SAM binding site; other site 272943003503 hypothetical protein; Provisional; Region: PRK07550 272943003504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943003505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003506 homodimer interface [polypeptide binding]; other site 272943003507 catalytic residue [active] 272943003508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943003509 active site 272943003510 LysE type translocator; Region: LysE; cl00565 272943003511 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 272943003512 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272943003513 NAD binding site [chemical binding]; other site 272943003514 homotetramer interface [polypeptide binding]; other site 272943003515 homodimer interface [polypeptide binding]; other site 272943003516 substrate binding site [chemical binding]; other site 272943003517 active site 272943003518 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 272943003519 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272943003520 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 272943003521 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943003522 DNA-binding site [nucleotide binding]; DNA binding site 272943003523 RNA-binding motif; other site 272943003524 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943003525 DNA-binding site [nucleotide binding]; DNA binding site 272943003526 RNA-binding motif; other site 272943003527 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 272943003528 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 272943003529 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 272943003530 Phage-related minor tail protein [Function unknown]; Region: COG5281 272943003531 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272943003532 Phage Terminase; Region: Terminase_1; cl19862 272943003533 Phage terminase, small subunit; Region: Terminase_4; pfam05119 272943003534 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272943003535 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272943003536 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 272943003537 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272943003538 oligomerization interface [polypeptide binding]; other site 272943003539 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943003540 active site 272943003541 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 272943003542 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272943003543 Phage capsid family; Region: Phage_capsid; pfam05065 272943003544 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 272943003545 Phage portal protein; Region: Phage_portal; pfam04860 272943003546 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 272943003547 Int/Topo IB signature motif; other site 272943003548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272943003549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943003550 DNA-binding site [nucleotide binding]; DNA binding site 272943003551 UTRA domain; Region: UTRA; pfam07702 272943003552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943003553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943003554 NAD(P) binding site [chemical binding]; other site 272943003555 active site 272943003556 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272943003557 intersubunit interface [polypeptide binding]; other site 272943003558 active site 272943003559 Zn2+ binding site [ion binding]; other site 272943003560 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 272943003561 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272943003562 putative ligand binding site [chemical binding]; other site 272943003563 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272943003564 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943003565 Walker A/P-loop; other site 272943003566 ATP binding site [chemical binding]; other site 272943003567 Q-loop/lid; other site 272943003568 ABC transporter signature motif; other site 272943003569 Walker B; other site 272943003570 D-loop; other site 272943003571 H-loop/switch region; other site 272943003572 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272943003573 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943003574 TM-ABC transporter signature motif; other site 272943003575 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943003576 TM-ABC transporter signature motif; other site 272943003577 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272943003578 substrate binding site [chemical binding]; other site 272943003579 ATP binding site [chemical binding]; other site 272943003580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943003581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943003582 NAD(P) binding site [chemical binding]; other site 272943003583 active site 272943003584 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 272943003585 NAD binding site [chemical binding]; other site 272943003586 catalytic residues [active] 272943003587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943003588 putative substrate translocation pore; other site 272943003589 hypothetical protein; Validated; Region: PRK00029 272943003590 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272943003591 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272943003592 substrate-cofactor binding pocket; other site 272943003593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003594 catalytic residue [active] 272943003595 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 272943003596 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272943003597 NAD(P) binding site [chemical binding]; other site 272943003598 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272943003599 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272943003600 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 272943003601 heme binding pocket [chemical binding]; other site 272943003602 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 272943003603 domain interactions; other site 272943003604 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272943003605 active site 272943003606 DNA binding site [nucleotide binding] 272943003607 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 272943003608 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 272943003609 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 272943003610 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 272943003611 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 272943003612 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 272943003613 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 272943003614 nudix motif; other site 272943003615 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272943003616 catalytic residues [active] 272943003617 dimer interface [polypeptide binding]; other site 272943003618 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 272943003619 active site 272943003620 Zn binding site [ion binding]; other site 272943003621 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 272943003622 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272943003623 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272943003624 NnrU protein; Region: NnrU; pfam07298 272943003625 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 272943003626 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272943003627 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 272943003628 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 272943003629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272943003630 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943003631 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943003632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943003633 dimer interface [polypeptide binding]; other site 272943003634 conserved gate region; other site 272943003635 putative PBP binding loops; other site 272943003636 ABC-ATPase subunit interface; other site 272943003637 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943003638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943003639 dimer interface [polypeptide binding]; other site 272943003640 conserved gate region; other site 272943003641 putative PBP binding loops; other site 272943003642 ABC-ATPase subunit interface; other site 272943003643 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943003644 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272943003645 Walker A/P-loop; other site 272943003646 ATP binding site [chemical binding]; other site 272943003647 Q-loop/lid; other site 272943003648 ABC transporter signature motif; other site 272943003649 Walker B; other site 272943003650 D-loop; other site 272943003651 H-loop/switch region; other site 272943003652 TOBE domain; Region: TOBE_2; pfam08402 272943003653 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272943003654 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 272943003655 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272943003656 N-terminal plug; other site 272943003657 ligand-binding site [chemical binding]; other site 272943003658 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272943003659 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272943003660 intersubunit interface [polypeptide binding]; other site 272943003661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943003662 ABC-ATPase subunit interface; other site 272943003663 dimer interface [polypeptide binding]; other site 272943003664 putative PBP binding regions; other site 272943003665 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272943003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943003667 Walker A/P-loop; other site 272943003668 ATP binding site [chemical binding]; other site 272943003669 Q-loop/lid; other site 272943003670 ABC transporter signature motif; other site 272943003671 Walker B; other site 272943003672 D-loop; other site 272943003673 H-loop/switch region; other site 272943003674 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 272943003675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943003676 dimer interface [polypeptide binding]; other site 272943003677 phosphorylation site [posttranslational modification] 272943003678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943003679 ATP binding site [chemical binding]; other site 272943003680 Mg2+ binding site [ion binding]; other site 272943003681 G-X-G motif; other site 272943003682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003683 active site 272943003684 phosphorylation site [posttranslational modification] 272943003685 intermolecular recognition site; other site 272943003686 dimerization interface [polypeptide binding]; other site 272943003687 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272943003688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272943003689 RNA binding surface [nucleotide binding]; other site 272943003690 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272943003691 active site 272943003692 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 272943003693 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272943003694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943003695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943003696 DNA binding residues [nucleotide binding] 272943003697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943003698 S-adenosylmethionine binding site [chemical binding]; other site 272943003699 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 272943003700 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 272943003701 active site 272943003702 Zn binding site [ion binding]; other site 272943003703 ATP-dependent DNA ligase; Validated; Region: PRK09247 272943003704 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 272943003705 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 272943003706 active site 272943003707 DNA binding site [nucleotide binding] 272943003708 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 272943003709 DNA binding site [nucleotide binding] 272943003710 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 272943003711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272943003712 Uncharacterized conserved protein [Function unknown]; Region: COG2308 272943003713 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272943003714 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272943003715 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272943003716 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272943003717 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 272943003718 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272943003719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943003720 SCP-2 sterol transfer family; Region: SCP2; pfam02036 272943003721 TPR repeat; Region: TPR_11; pfam13414 272943003722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272943003723 binding surface 272943003724 TPR motif; other site 272943003725 TPR repeat; Region: TPR_11; pfam13414 272943003726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943003727 ATP binding site [chemical binding]; other site 272943003728 putative Mg++ binding site [ion binding]; other site 272943003729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943003730 nucleotide binding region [chemical binding]; other site 272943003731 ATP-binding site [chemical binding]; other site 272943003732 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272943003733 RNA binding surface [nucleotide binding]; other site 272943003734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272943003735 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272943003736 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 272943003737 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 272943003738 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 272943003739 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272943003740 putative dimer interface [polypeptide binding]; other site 272943003741 active site pocket [active] 272943003742 putative cataytic base [active] 272943003743 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272943003744 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 272943003745 TrkA-N domain; Region: TrkA_N; pfam02254 272943003746 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 272943003747 large tegument protein UL36; Provisional; Region: PHA03247 272943003748 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 272943003749 Protein of unknown function (DUF541); Region: SIMPL; cl01077 272943003750 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272943003751 homodimer interface [polypeptide binding]; other site 272943003752 substrate-cofactor binding pocket; other site 272943003753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943003754 catalytic residue [active] 272943003755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003756 active site 272943003757 phosphorylation site [posttranslational modification] 272943003758 intermolecular recognition site; other site 272943003759 dimerization interface [polypeptide binding]; other site 272943003760 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272943003761 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 272943003762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943003763 S-adenosylmethionine binding site [chemical binding]; other site 272943003764 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 272943003765 putative CheA interaction surface; other site 272943003766 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272943003767 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272943003768 putative binding surface; other site 272943003769 active site 272943003770 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272943003771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943003772 ATP binding site [chemical binding]; other site 272943003773 Mg2+ binding site [ion binding]; other site 272943003774 G-X-G motif; other site 272943003775 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272943003776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943003777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003778 active site 272943003779 phosphorylation site [posttranslational modification] 272943003780 intermolecular recognition site; other site 272943003781 dimerization interface [polypeptide binding]; other site 272943003782 STAS domain; Region: STAS_2; pfam13466 272943003783 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13491 272943003784 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272943003785 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272943003786 dimer interface [polypeptide binding]; other site 272943003787 putative CheW interface [polypeptide binding]; other site 272943003788 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272943003789 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272943003790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943003791 dimerization interface [polypeptide binding]; other site 272943003792 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943003793 dimer interface [polypeptide binding]; other site 272943003794 putative CheW interface [polypeptide binding]; other site 272943003795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943003796 active site 272943003797 phosphorylation site [posttranslational modification] 272943003798 intermolecular recognition site; other site 272943003799 dimerization interface [polypeptide binding]; other site 272943003800 STAS domain; Region: STAS_2; pfam13466 272943003801 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 272943003802 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272943003803 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 272943003804 active site 272943003805 homodimer interface [polypeptide binding]; other site 272943003806 catalytic site [active] 272943003807 acceptor binding site [chemical binding]; other site 272943003808 trehalose synthase; Region: treS_nterm; TIGR02456 272943003809 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 272943003810 active site 272943003811 catalytic site [active] 272943003812 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272943003813 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 272943003814 glycogen branching enzyme; Provisional; Region: PRK05402 272943003815 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272943003816 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272943003817 active site 272943003818 catalytic site [active] 272943003819 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272943003820 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 272943003821 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272943003822 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272943003823 active site 272943003824 catalytic site [active] 272943003825 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 272943003826 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 272943003827 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 272943003828 catalytic site [active] 272943003829 active site 272943003830 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272943003831 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 272943003832 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 272943003833 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 272943003834 active site 272943003835 catalytic site [active] 272943003836 short chain dehydrogenase; Region: adh_short; pfam00106 272943003837 classical (c) SDRs; Region: SDR_c; cd05233 272943003838 NAD(P) binding site [chemical binding]; other site 272943003839 active site 272943003840 amidophosphoribosyltransferase; Provisional; Region: PRK09123 272943003841 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272943003842 active site 272943003843 tetramer interface [polypeptide binding]; other site 272943003844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943003845 active site 272943003846 Colicin V production protein; Region: Colicin_V; pfam02674 272943003847 DNA repair protein RadA; Provisional; Region: PRK11823 272943003848 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272943003849 Walker A motif/ATP binding site; other site 272943003850 ATP binding site [chemical binding]; other site 272943003851 Walker B motif; other site 272943003852 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272943003853 Paraquat-inducible protein A; Region: PqiA; pfam04403 272943003854 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272943003855 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272943003856 Walker A/P-loop; other site 272943003857 ATP binding site [chemical binding]; other site 272943003858 Q-loop/lid; other site 272943003859 ABC transporter signature motif; other site 272943003860 Walker B; other site 272943003861 D-loop; other site 272943003862 H-loop/switch region; other site 272943003863 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272943003864 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272943003865 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272943003866 active site 272943003867 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272943003868 dimer interface [polypeptide binding]; other site 272943003869 substrate binding site [chemical binding]; other site 272943003870 catalytic residues [active] 272943003871 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272943003872 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272943003873 homotetramer interface [polypeptide binding]; other site 272943003874 NAD(P) binding site [chemical binding]; other site 272943003875 homodimer interface [polypeptide binding]; other site 272943003876 active site 272943003877 acyl carrier protein; Provisional; Region: acpP; PRK00982 272943003878 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 272943003879 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272943003880 dimer interface [polypeptide binding]; other site 272943003881 active site 272943003882 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272943003883 dimerization interface [polypeptide binding]; other site 272943003884 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]; Region: COG2250 272943003885 Uncharacterized conserved protein [Function unknown]; Region: COG5323 272943003886 Terminase-like family; Region: Terminase_6; pfam03237 272943003887 Phage-related protein [Function unknown]; Region: COG4695 272943003888 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 272943003889 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272943003890 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 272943003891 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272943003892 oligomerization interface [polypeptide binding]; other site 272943003893 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272943003894 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272943003895 Phage major tail protein 2; Region: Phage_tail_2; cl11463 272943003896 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 272943003897 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 272943003898 Phage-related minor tail protein [Function unknown]; Region: COG5281 272943003899 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 272943003900 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 272943003901 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 272943003902 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 272943003903 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 272943003904 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272943003905 NlpC/P60 family; Region: NLPC_P60; cl17555 272943003906 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 272943003907 Putative phage tail protein; Region: Phage-tail_3; pfam13550 272943003908 serine acetyltransferase; Provisional; Region: cysE; PRK11132 272943003909 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 272943003910 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272943003911 trimer interface [polypeptide binding]; other site 272943003912 active site 272943003913 substrate binding site [chemical binding]; other site 272943003914 CoA binding site [chemical binding]; other site 272943003915 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272943003916 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 272943003917 E3 interaction surface; other site 272943003918 lipoyl attachment site [posttranslational modification]; other site 272943003919 e3 binding domain; Region: E3_binding; pfam02817 272943003920 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272943003921 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 272943003922 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272943003923 E3 interaction surface; other site 272943003924 lipoyl attachment site [posttranslational modification]; other site 272943003925 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272943003926 alpha subunit interface [polypeptide binding]; other site 272943003927 TPP binding site [chemical binding]; other site 272943003928 heterodimer interface [polypeptide binding]; other site 272943003929 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272943003930 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272943003931 tetramer interface [polypeptide binding]; other site 272943003932 TPP-binding site [chemical binding]; other site 272943003933 heterodimer interface [polypeptide binding]; other site 272943003934 phosphorylation loop region [posttranslational modification] 272943003935 Septum formation initiator; Region: DivIC; cl17659 272943003936 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 272943003937 putative active site; other site 272943003938 catalytic residue [active] 272943003939 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 272943003940 substrate binding site [chemical binding]; other site 272943003941 hinge regions; other site 272943003942 ADP binding site [chemical binding]; other site 272943003943 catalytic site [active] 272943003944 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272943003945 active site 272943003946 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272943003947 active site 272943003948 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272943003949 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272943003950 active site 272943003951 HIGH motif; other site 272943003952 dimer interface [polypeptide binding]; other site 272943003953 KMSKS motif; other site 272943003954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272943003955 RNA binding surface [nucleotide binding]; other site 272943003956 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 272943003957 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 272943003958 enolase; Provisional; Region: eno; PRK00077 272943003959 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272943003960 dimer interface [polypeptide binding]; other site 272943003961 metal binding site [ion binding]; metal-binding site 272943003962 substrate binding pocket [chemical binding]; other site 272943003963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943003964 EamA-like transporter family; Region: EamA; pfam00892 272943003965 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272943003966 metal binding site 2 [ion binding]; metal-binding site 272943003967 putative DNA binding helix; other site 272943003968 metal binding site 1 [ion binding]; metal-binding site 272943003969 dimer interface [polypeptide binding]; other site 272943003970 structural Zn2+ binding site [ion binding]; other site 272943003971 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 272943003972 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 272943003973 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 272943003974 active site 272943003975 dimer interface [polypeptide binding]; other site 272943003976 effector binding site; other site 272943003977 Transcriptional regulator; Region: Transcrip_reg; cl00361 272943003978 TSCPD domain; Region: TSCPD; pfam12637 272943003979 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272943003980 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 272943003981 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 272943003982 dimerization interface [polypeptide binding]; other site 272943003983 active site 272943003984 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272943003985 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272943003986 glutaminase active site [active] 272943003987 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272943003988 dimer interface [polypeptide binding]; other site 272943003989 active site 272943003990 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272943003991 dimer interface [polypeptide binding]; other site 272943003992 active site 272943003993 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 272943003994 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272943003995 Substrate binding site; other site 272943003996 Mg++ binding site; other site 272943003997 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272943003998 active site 272943003999 substrate binding site [chemical binding]; other site 272943004000 CoA binding site [chemical binding]; other site 272943004001 phosphoglycolate phosphatase; Provisional; Region: PRK13222 272943004002 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272943004003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943004004 motif II; other site 272943004005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 272943004006 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 272943004007 isovaleryl-CoA dehydrogenase; Region: PLN02519 272943004008 substrate binding site [chemical binding]; other site 272943004009 FAD binding site [chemical binding]; other site 272943004010 catalytic base [active] 272943004011 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 272943004012 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272943004013 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272943004014 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 272943004015 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272943004016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272943004017 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272943004018 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272943004019 carboxyltransferase (CT) interaction site; other site 272943004020 biotinylation site [posttranslational modification]; other site 272943004021 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 272943004022 active site 272943004023 catalytic residues [active] 272943004024 metal binding site [ion binding]; metal-binding site 272943004025 enoyl-CoA hydratase; Provisional; Region: PRK07468 272943004026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943004027 substrate binding site [chemical binding]; other site 272943004028 oxyanion hole (OAH) forming residues; other site 272943004029 trimer interface [polypeptide binding]; other site 272943004030 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 272943004031 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272943004032 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 272943004033 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272943004034 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 272943004035 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 272943004036 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272943004037 putative dimer interface [polypeptide binding]; other site 272943004038 [2Fe-2S] cluster binding site [ion binding]; other site 272943004039 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 272943004040 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272943004041 SLBB domain; Region: SLBB; pfam10531 272943004042 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 272943004043 NADH dehydrogenase subunit G; Validated; Region: PRK09130 272943004044 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943004045 catalytic loop [active] 272943004046 iron binding site [ion binding]; other site 272943004047 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272943004048 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 272943004049 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 272943004050 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272943004051 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272943004052 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272943004053 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272943004054 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272943004055 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 272943004056 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272943004057 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272943004058 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943004059 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272943004060 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943004061 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272943004062 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943004063 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272943004064 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272943004065 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272943004066 pantothenate kinase; Reviewed; Region: PRK13318 272943004067 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272943004068 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272943004069 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272943004070 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 272943004071 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 272943004072 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272943004073 ATP binding site [chemical binding]; other site 272943004074 Mg++ binding site [ion binding]; other site 272943004075 motif III; other site 272943004076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943004077 nucleotide binding region [chemical binding]; other site 272943004078 ATP-binding site [chemical binding]; other site 272943004079 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 272943004080 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272943004081 G1 box; other site 272943004082 putative GEF interaction site [polypeptide binding]; other site 272943004083 GTP/Mg2+ binding site [chemical binding]; other site 272943004084 Switch I region; other site 272943004085 G2 box; other site 272943004086 G3 box; other site 272943004087 Switch II region; other site 272943004088 G4 box; other site 272943004089 G5 box; other site 272943004090 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272943004091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943004092 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 272943004093 NAD(P) binding site [chemical binding]; other site 272943004094 active site 272943004095 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943004096 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 272943004097 Walker A/P-loop; other site 272943004098 ATP binding site [chemical binding]; other site 272943004099 Q-loop/lid; other site 272943004100 ABC transporter signature motif; other site 272943004101 Walker B; other site 272943004102 D-loop; other site 272943004103 H-loop/switch region; other site 272943004104 TOBE domain; Region: TOBE_2; pfam08402 272943004105 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 272943004106 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 272943004107 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272943004108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943004109 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272943004110 Walker A motif; other site 272943004111 ATP binding site [chemical binding]; other site 272943004112 Walker B motif; other site 272943004113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272943004114 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272943004115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272943004116 Peptidase family M23; Region: Peptidase_M23; pfam01551 272943004117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943004118 S-adenosylmethionine binding site [chemical binding]; other site 272943004119 stationary phase survival protein SurE; Provisional; Region: PRK13931 272943004120 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272943004121 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 272943004122 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272943004123 SLBB domain; Region: SLBB; pfam10531 272943004124 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 272943004125 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272943004126 O-Antigen ligase; Region: Wzy_C; pfam04932 272943004127 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 272943004128 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 272943004129 active site 272943004130 catalytic residues [active] 272943004131 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272943004132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272943004133 active site 272943004134 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272943004135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272943004136 active site 272943004137 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 272943004138 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 272943004139 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 272943004140 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272943004141 active site 272943004142 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 272943004143 dimer interface [polypeptide binding]; other site 272943004144 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272943004145 Ligand Binding Site [chemical binding]; other site 272943004146 Molecular Tunnel; other site 272943004147 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272943004148 Hpr binding site; other site 272943004149 active site 272943004150 homohexamer subunit interaction site [polypeptide binding]; other site 272943004151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943004152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943004153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943004154 Walker A/P-loop; other site 272943004155 ATP binding site [chemical binding]; other site 272943004156 Q-loop/lid; other site 272943004157 ABC transporter signature motif; other site 272943004158 Walker B; other site 272943004159 D-loop; other site 272943004160 H-loop/switch region; other site 272943004161 Chain length determinant protein; Region: Wzz; pfam02706 272943004162 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 272943004163 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272943004164 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943004165 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943004166 P-loop; other site 272943004167 Magnesium ion binding site [ion binding]; other site 272943004168 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272943004169 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272943004170 active site 272943004171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943004172 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272943004173 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 272943004174 Ligand binding site; other site 272943004175 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943004176 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272943004177 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272943004178 active site 272943004179 tetramer interface; other site 272943004180 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943004181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943004182 NAD(P) binding site [chemical binding]; other site 272943004183 active site 272943004184 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 272943004185 substrate binding site; other site 272943004186 Manganese binding site; other site 272943004187 dimer interface; other site 272943004188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943004189 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943004190 NAD(P) binding site [chemical binding]; other site 272943004191 active site 272943004192 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272943004193 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272943004194 proposed catalytic triad [active] 272943004195 conserved cys residue [active] 272943004196 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 272943004197 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943004198 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943004199 ligand binding site [chemical binding]; other site 272943004200 flexible hinge region; other site 272943004201 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272943004202 putative switch regulator; other site 272943004203 non-specific DNA interactions [nucleotide binding]; other site 272943004204 DNA binding site [nucleotide binding] 272943004205 sequence specific DNA binding site [nucleotide binding]; other site 272943004206 putative cAMP binding site [chemical binding]; other site 272943004207 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943004208 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272943004209 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 272943004210 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 272943004211 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 272943004212 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 272943004213 substrate binding site [chemical binding]; other site 272943004214 catalytic Zn binding site [ion binding]; other site 272943004215 NAD binding site [chemical binding]; other site 272943004216 structural Zn binding site [ion binding]; other site 272943004217 dimer interface [polypeptide binding]; other site 272943004218 Cytochrome c2 [Energy production and conversion]; Region: COG3474 272943004219 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272943004220 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 272943004221 Trp docking motif [polypeptide binding]; other site 272943004222 dimer interface [polypeptide binding]; other site 272943004223 active site 272943004224 small subunit binding site [polypeptide binding]; other site 272943004225 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 272943004226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272943004227 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272943004228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272943004229 substrate binding pocket [chemical binding]; other site 272943004230 membrane-bound complex binding site; other site 272943004231 hinge residues; other site 272943004232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272943004233 active site residue [active] 272943004234 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 272943004235 ligand binding site [chemical binding]; other site 272943004236 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272943004237 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272943004238 structural tetrad; other site 272943004239 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272943004240 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272943004241 Cupredoxin superfamily; Region: Cupredoxin; cl19115 272943004242 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 272943004243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943004244 Walker A/P-loop; other site 272943004245 ATP binding site [chemical binding]; other site 272943004246 Q-loop/lid; other site 272943004247 ABC transporter signature motif; other site 272943004248 Walker B; other site 272943004249 D-loop; other site 272943004250 H-loop/switch region; other site 272943004251 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272943004252 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272943004253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272943004254 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 272943004255 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 272943004256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943004257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004258 active site 272943004259 phosphorylation site [posttranslational modification] 272943004260 intermolecular recognition site; other site 272943004261 dimerization interface [polypeptide binding]; other site 272943004262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943004263 DNA binding residues [nucleotide binding] 272943004264 dimerization interface [polypeptide binding]; other site 272943004265 Uncharacterized conserved protein [Function unknown]; Region: COG3287 272943004266 FIST N domain; Region: FIST; pfam08495 272943004267 FIST C domain; Region: FIST_C; pfam10442 272943004268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943004269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943004270 dimer interface [polypeptide binding]; other site 272943004271 phosphorylation site [posttranslational modification] 272943004272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943004273 ATP binding site [chemical binding]; other site 272943004274 Mg2+ binding site [ion binding]; other site 272943004275 G-X-G motif; other site 272943004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004277 active site 272943004278 phosphorylation site [posttranslational modification] 272943004279 intermolecular recognition site; other site 272943004280 dimerization interface [polypeptide binding]; other site 272943004281 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272943004282 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272943004283 Walker A/P-loop; other site 272943004284 ATP binding site [chemical binding]; other site 272943004285 Q-loop/lid; other site 272943004286 ABC transporter signature motif; other site 272943004287 Walker B; other site 272943004288 D-loop; other site 272943004289 H-loop/switch region; other site 272943004290 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272943004291 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943004292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004293 dimer interface [polypeptide binding]; other site 272943004294 conserved gate region; other site 272943004295 putative PBP binding loops; other site 272943004296 ABC-ATPase subunit interface; other site 272943004297 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 272943004298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004299 active site 272943004300 phosphorylation site [posttranslational modification] 272943004301 intermolecular recognition site; other site 272943004302 dimerization interface [polypeptide binding]; other site 272943004303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943004304 DNA binding site [nucleotide binding] 272943004305 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272943004306 PhoU domain; Region: PhoU; pfam01895 272943004307 PhoU domain; Region: PhoU; pfam01895 272943004308 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 272943004309 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272943004310 Walker A/P-loop; other site 272943004311 ATP binding site [chemical binding]; other site 272943004312 Q-loop/lid; other site 272943004313 ABC transporter signature motif; other site 272943004314 Walker B; other site 272943004315 D-loop; other site 272943004316 H-loop/switch region; other site 272943004317 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 272943004318 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272943004319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004320 dimer interface [polypeptide binding]; other site 272943004321 conserved gate region; other site 272943004322 putative PBP binding loops; other site 272943004323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272943004324 ABC-ATPase subunit interface; other site 272943004325 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 272943004326 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272943004327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004328 dimer interface [polypeptide binding]; other site 272943004329 conserved gate region; other site 272943004330 putative PBP binding loops; other site 272943004331 ABC-ATPase subunit interface; other site 272943004332 PBP superfamily domain; Region: PBP_like_2; pfam12849 272943004333 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 272943004334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943004335 dimerization interface [polypeptide binding]; other site 272943004336 putative DNA binding site [nucleotide binding]; other site 272943004337 putative Zn2+ binding site [ion binding]; other site 272943004338 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 272943004339 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272943004340 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 272943004341 Cl binding site [ion binding]; other site 272943004342 oligomer interface [polypeptide binding]; other site 272943004343 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 272943004344 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 272943004345 trimer interface [polypeptide binding]; other site 272943004346 active site 272943004347 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 272943004348 trimer interface [polypeptide binding]; other site 272943004349 active site 272943004350 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 272943004351 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272943004352 DNA binding residues [nucleotide binding] 272943004353 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 272943004354 DNA binding site [nucleotide binding] 272943004355 dimer interface [polypeptide binding]; other site 272943004356 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272943004357 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272943004358 dimer interface [polypeptide binding]; other site 272943004359 active site 272943004360 CoA binding pocket [chemical binding]; other site 272943004361 putative phosphate acyltransferase; Provisional; Region: PRK05331 272943004362 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272943004363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272943004364 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 272943004365 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 272943004366 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272943004367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 272943004368 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272943004369 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272943004370 Ligand Binding Site [chemical binding]; other site 272943004371 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 272943004372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943004373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004374 active site 272943004375 phosphorylation site [posttranslational modification] 272943004376 intermolecular recognition site; other site 272943004377 dimerization interface [polypeptide binding]; other site 272943004378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943004379 DNA binding site [nucleotide binding] 272943004380 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272943004381 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272943004382 nucleotide binding pocket [chemical binding]; other site 272943004383 K-X-D-G motif; other site 272943004384 catalytic site [active] 272943004385 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272943004386 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272943004387 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272943004388 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272943004389 Dimer interface [polypeptide binding]; other site 272943004390 BRCT sequence motif; other site 272943004391 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272943004392 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272943004393 generic binding surface II; other site 272943004394 ssDNA binding site; other site 272943004395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943004396 ATP binding site [chemical binding]; other site 272943004397 putative Mg++ binding site [ion binding]; other site 272943004398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943004399 nucleotide binding region [chemical binding]; other site 272943004400 ATP-binding site [chemical binding]; other site 272943004401 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272943004402 trimerization site [polypeptide binding]; other site 272943004403 active site 272943004404 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 272943004405 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 272943004406 active site 272943004407 nucleotide binding site [chemical binding]; other site 272943004408 HIGH motif; other site 272943004409 KMSKS motif; other site 272943004410 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272943004411 Glucose inhibited division protein A; Region: GIDA; pfam01134 272943004412 DNA gyrase subunit A; Validated; Region: PRK05560 272943004413 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272943004414 CAP-like domain; other site 272943004415 active site 272943004416 primary dimer interface [polypeptide binding]; other site 272943004417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272943004418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272943004419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272943004420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272943004421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272943004422 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272943004423 Usg-like family; Region: Usg; pfam06233 272943004424 Arginase family; Region: Arginase; cd09989 272943004425 active site 272943004426 Mn binding site [ion binding]; other site 272943004427 oligomer interface [polypeptide binding]; other site 272943004428 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 272943004429 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 272943004430 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272943004431 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272943004432 putative valine binding site [chemical binding]; other site 272943004433 dimer interface [polypeptide binding]; other site 272943004434 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272943004435 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 272943004436 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272943004437 PYR/PP interface [polypeptide binding]; other site 272943004438 dimer interface [polypeptide binding]; other site 272943004439 TPP binding site [chemical binding]; other site 272943004440 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272943004441 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272943004442 TPP-binding site [chemical binding]; other site 272943004443 dimer interface [polypeptide binding]; other site 272943004444 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 272943004445 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272943004446 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272943004447 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 272943004448 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 272943004449 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 272943004450 RDD family; Region: RDD; pfam06271 272943004451 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 272943004452 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 272943004453 putative deacylase active site [active] 272943004454 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 272943004455 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272943004456 metal binding triad; other site 272943004457 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272943004458 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272943004459 metal binding triad; other site 272943004460 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 272943004461 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272943004462 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272943004463 active site 272943004464 intersubunit interface [polypeptide binding]; other site 272943004465 catalytic residue [active] 272943004466 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272943004467 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 272943004468 putative RNA binding site [nucleotide binding]; other site 272943004469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943004470 S-adenosylmethionine binding site [chemical binding]; other site 272943004471 PIN domain; Region: PIN_3; pfam13470 272943004472 Peptidase family M48; Region: Peptidase_M48; cl12018 272943004473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 272943004474 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 272943004475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272943004476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943004477 Coenzyme A binding pocket [chemical binding]; other site 272943004478 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272943004479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943004480 Walker A motif; other site 272943004481 ATP binding site [chemical binding]; other site 272943004482 Walker B motif; other site 272943004483 arginine finger; other site 272943004484 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 272943004485 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 272943004486 Squalene epoxidase; Region: SE; cl17314 272943004487 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272943004488 CoenzymeA binding site [chemical binding]; other site 272943004489 subunit interaction site [polypeptide binding]; other site 272943004490 PHB binding site; other site 272943004491 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272943004492 putative catalytic site [active] 272943004493 putative phosphate binding site [ion binding]; other site 272943004494 active site 272943004495 metal binding site A [ion binding]; metal-binding site 272943004496 DNA binding site [nucleotide binding] 272943004497 putative AP binding site [nucleotide binding]; other site 272943004498 putative metal binding site B [ion binding]; other site 272943004499 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272943004500 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 272943004501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272943004502 Zn2+ binding site [ion binding]; other site 272943004503 Mg2+ binding site [ion binding]; other site 272943004504 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272943004505 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272943004506 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 272943004507 putative active site [active] 272943004508 metal binding site [ion binding]; metal-binding site 272943004509 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 272943004510 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272943004511 N- and C-terminal domain interface [polypeptide binding]; other site 272943004512 active site 272943004513 MgATP binding site [chemical binding]; other site 272943004514 catalytic site [active] 272943004515 metal binding site [ion binding]; metal-binding site 272943004516 glycerol binding site [chemical binding]; other site 272943004517 homotetramer interface [polypeptide binding]; other site 272943004518 homodimer interface [polypeptide binding]; other site 272943004519 FBP binding site [chemical binding]; other site 272943004520 protein IIAGlc interface [polypeptide binding]; other site 272943004521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943004522 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272943004523 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 272943004524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943004525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004526 dimer interface [polypeptide binding]; other site 272943004527 conserved gate region; other site 272943004528 putative PBP binding loops; other site 272943004529 ABC-ATPase subunit interface; other site 272943004530 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272943004531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004532 dimer interface [polypeptide binding]; other site 272943004533 conserved gate region; other site 272943004534 putative PBP binding loops; other site 272943004535 ABC-ATPase subunit interface; other site 272943004536 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272943004537 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 272943004538 Walker A/P-loop; other site 272943004539 ATP binding site [chemical binding]; other site 272943004540 Q-loop/lid; other site 272943004541 ABC transporter signature motif; other site 272943004542 Walker B; other site 272943004543 D-loop; other site 272943004544 H-loop/switch region; other site 272943004545 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272943004546 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 272943004547 Walker A/P-loop; other site 272943004548 ATP binding site [chemical binding]; other site 272943004549 Q-loop/lid; other site 272943004550 ABC transporter signature motif; other site 272943004551 Walker B; other site 272943004552 D-loop; other site 272943004553 H-loop/switch region; other site 272943004554 TOBE domain; Region: TOBE_2; pfam08402 272943004555 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 272943004556 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272943004557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 272943004558 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 272943004559 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 272943004560 Trp docking motif [polypeptide binding]; other site 272943004561 putative active site [active] 272943004562 PRC-barrel domain; Region: PRC; pfam05239 272943004563 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272943004564 BON domain; Region: BON; pfam04972 272943004565 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943004566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004567 active site 272943004568 phosphorylation site [posttranslational modification] 272943004569 intermolecular recognition site; other site 272943004570 dimerization interface [polypeptide binding]; other site 272943004571 MgtC family; Region: MgtC; pfam02308 272943004572 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 272943004573 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 272943004574 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 272943004575 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 272943004576 active site 272943004577 DNA binding site [nucleotide binding] 272943004578 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 272943004579 DNA binding site [nucleotide binding] 272943004580 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 272943004581 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 272943004582 nucleotide binding site [chemical binding]; other site 272943004583 RNA polymerase sigma factor; Provisional; Region: PRK11924 272943004584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943004585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943004586 DNA binding residues [nucleotide binding] 272943004587 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272943004588 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 272943004589 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272943004590 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 272943004591 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 272943004592 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 272943004593 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272943004594 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 272943004595 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 272943004596 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 272943004597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943004598 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 272943004599 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272943004600 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 272943004601 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272943004602 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272943004603 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272943004604 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272943004605 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 272943004606 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272943004607 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943004608 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272943004609 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 272943004610 Walker A/P-loop; other site 272943004611 ATP binding site [chemical binding]; other site 272943004612 Q-loop/lid; other site 272943004613 ABC transporter signature motif; other site 272943004614 Walker B; other site 272943004615 D-loop; other site 272943004616 H-loop/switch region; other site 272943004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 272943004618 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 272943004619 Trp docking motif [polypeptide binding]; other site 272943004620 active site 272943004621 PQQ-like domain; Region: PQQ_2; pfam13360 272943004622 PQQ-like domain; Region: PQQ_2; pfam13360 272943004623 GTP-binding protein Der; Reviewed; Region: PRK00093 272943004624 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272943004625 G1 box; other site 272943004626 GTP/Mg2+ binding site [chemical binding]; other site 272943004627 Switch I region; other site 272943004628 G2 box; other site 272943004629 Switch II region; other site 272943004630 G3 box; other site 272943004631 G4 box; other site 272943004632 G5 box; other site 272943004633 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272943004634 G1 box; other site 272943004635 GTP/Mg2+ binding site [chemical binding]; other site 272943004636 Switch I region; other site 272943004637 G2 box; other site 272943004638 G3 box; other site 272943004639 Switch II region; other site 272943004640 G4 box; other site 272943004641 G5 box; other site 272943004642 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272943004643 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272943004644 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943004645 Walker A/P-loop; other site 272943004646 ATP binding site [chemical binding]; other site 272943004647 Q-loop/lid; other site 272943004648 ABC transporter signature motif; other site 272943004649 Walker B; other site 272943004650 D-loop; other site 272943004651 H-loop/switch region; other site 272943004652 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943004653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943004654 Walker A/P-loop; other site 272943004655 ATP binding site [chemical binding]; other site 272943004656 Q-loop/lid; other site 272943004657 ABC transporter signature motif; other site 272943004658 Walker B; other site 272943004659 D-loop; other site 272943004660 H-loop/switch region; other site 272943004661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943004662 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 272943004663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004664 dimer interface [polypeptide binding]; other site 272943004665 conserved gate region; other site 272943004666 putative PBP binding loops; other site 272943004667 ABC-ATPase subunit interface; other site 272943004668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943004669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943004670 dimer interface [polypeptide binding]; other site 272943004671 conserved gate region; other site 272943004672 putative PBP binding loops; other site 272943004673 ABC-ATPase subunit interface; other site 272943004674 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272943004675 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272943004676 putative nucleotide binding site [chemical binding]; other site 272943004677 uridine monophosphate binding site [chemical binding]; other site 272943004678 homohexameric interface [polypeptide binding]; other site 272943004679 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272943004680 hinge region; other site 272943004681 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272943004682 active site 272943004683 dimer interface [polypeptide binding]; other site 272943004684 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272943004685 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272943004686 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272943004687 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272943004688 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272943004689 RIP metalloprotease RseP; Region: TIGR00054 272943004690 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272943004691 active site 272943004692 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272943004693 protein binding site [polypeptide binding]; other site 272943004694 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272943004695 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272943004696 putative substrate binding region [chemical binding]; other site 272943004697 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 272943004698 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272943004699 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272943004700 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272943004701 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272943004702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272943004703 Surface antigen; Region: Bac_surface_Ag; pfam01103 272943004704 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 272943004705 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272943004706 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 272943004707 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272943004708 active site 272943004709 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 272943004710 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272943004711 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272943004712 ABC transporter ATPase component; Reviewed; Region: PRK11147 272943004713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943004714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943004715 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 272943004716 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943004717 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 272943004718 putative DNA binding site [nucleotide binding]; other site 272943004719 putative Zn2+ binding site [ion binding]; other site 272943004720 LysE type translocator; Region: LysE; cl00565 272943004721 YjbR; Region: YjbR; pfam04237 272943004722 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272943004723 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272943004724 active site 272943004725 HIGH motif; other site 272943004726 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943004727 KMSKS motif; other site 272943004728 active site 272943004729 KMSKS motif; other site 272943004730 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272943004731 tRNA binding surface [nucleotide binding]; other site 272943004732 anticodon binding site; other site 272943004733 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 272943004734 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 272943004735 active site 272943004736 catalytic residues [active] 272943004737 metal binding site [ion binding]; metal-binding site 272943004738 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272943004739 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272943004740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943004741 S-adenosylmethionine binding site [chemical binding]; other site 272943004742 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 272943004743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943004744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943004745 putative substrate translocation pore; other site 272943004746 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 272943004747 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272943004748 minor groove reading motif; other site 272943004749 helix-hairpin-helix signature motif; other site 272943004750 substrate binding pocket [chemical binding]; other site 272943004751 active site 272943004752 Predicted esterase [General function prediction only]; Region: COG0400 272943004753 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943004754 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943004755 active site 272943004756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943004757 dimerization interface [polypeptide binding]; other site 272943004758 putative DNA binding site [nucleotide binding]; other site 272943004759 putative Zn2+ binding site [ion binding]; other site 272943004760 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272943004761 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272943004762 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943004763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943004764 putative substrate translocation pore; other site 272943004765 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272943004766 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272943004767 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272943004768 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272943004769 putative active site [active] 272943004770 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 272943004771 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272943004772 active site 272943004773 dimer interface [polypeptide binding]; other site 272943004774 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272943004775 dimer interface [polypeptide binding]; other site 272943004776 active site 272943004777 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 272943004778 homotrimer interaction site [polypeptide binding]; other site 272943004779 putative active site [active] 272943004780 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272943004781 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272943004782 active site residue [active] 272943004783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272943004784 active site residue [active] 272943004785 Sulphur transport; Region: Sulf_transp; pfam04143 272943004786 Sulphur transport; Region: Sulf_transp; cl19477 272943004787 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272943004788 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 272943004789 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272943004790 Cytochrome c; Region: Cytochrom_C; cl11414 272943004791 Cytochrome c; Region: Cytochrom_C; cl11414 272943004792 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272943004793 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943004794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943004795 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943004796 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 272943004797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 272943004798 integrase; Provisional; Region: PRK09692 272943004799 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272943004800 active site 272943004801 Int/Topo IB signature motif; other site 272943004802 Helix-turn-helix domain; Region: HTH_36; pfam13730 272943004803 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 272943004804 Phage Tail Protein X; Region: Phage_tail_X; cl02088 272943004805 Protein of unknown function (DUF497); Region: DUF497; cl01108 272943004806 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 272943004807 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 272943004808 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943004809 catalytic loop [active] 272943004810 iron binding site [ion binding]; other site 272943004811 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 272943004812 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 272943004813 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 272943004814 substrate binding pocket [chemical binding]; other site 272943004815 dimer interface [polypeptide binding]; other site 272943004816 inhibitor binding site; inhibition site 272943004817 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 272943004818 FAD binding site [chemical binding]; other site 272943004819 Virulence factor; Region: Virulence_fact; pfam13769 272943004820 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272943004821 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 272943004822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943004823 S-adenosylmethionine binding site [chemical binding]; other site 272943004824 Peptidase M15; Region: Peptidase_M15_3; cl01194 272943004825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 272943004826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 272943004827 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943004828 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943004829 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272943004830 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272943004831 trimer interface [polypeptide binding]; other site 272943004832 active site 272943004833 UDP-GlcNAc binding site [chemical binding]; other site 272943004834 lipid binding site [chemical binding]; lipid-binding site 272943004835 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272943004836 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272943004837 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272943004838 dimer interface [polypeptide binding]; other site 272943004839 active site 272943004840 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 272943004841 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272943004842 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 272943004843 tetramer interface [polypeptide binding]; other site 272943004844 heme binding pocket [chemical binding]; other site 272943004845 NADPH binding site [chemical binding]; other site 272943004846 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272943004847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943004848 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272943004849 dimerization interface [polypeptide binding]; other site 272943004850 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 272943004851 catalytic triad [active] 272943004852 dimer interface [polypeptide binding]; other site 272943004853 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 272943004854 amphipathic channel; other site 272943004855 Asn-Pro-Ala signature motifs; other site 272943004856 lipoyl synthase; Provisional; Region: PRK05481 272943004857 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272943004858 Cytochrome c; Region: Cytochrom_C; pfam00034 272943004859 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272943004860 Cytochrome c; Region: Cytochrom_C; pfam00034 272943004861 Cytochrome C' Region: Cytochrom_C_2; pfam01322 272943004862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943004863 active site 272943004864 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 272943004865 putative coenzyme Q binding site [chemical binding]; other site 272943004866 Winged helix-turn helix; Region: HTH_29; pfam13551 272943004867 Helix-turn-helix domain; Region: HTH_28; pfam13518 272943004868 Homeodomain-like domain; Region: HTH_32; pfam13565 272943004869 Integrase core domain; Region: rve; pfam00665 272943004870 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272943004871 substrate binding site [chemical binding]; other site 272943004872 hexamer interface [polypeptide binding]; other site 272943004873 metal binding site [ion binding]; metal-binding site 272943004874 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943004875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943004876 elongation factor Ts; Provisional; Region: tsf; PRK09377 272943004877 UBA/TS-N domain; Region: UBA; pfam00627 272943004878 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272943004879 rRNA interaction site [nucleotide binding]; other site 272943004880 S8 interaction site; other site 272943004881 putative laminin-1 binding site; other site 272943004882 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 272943004883 substrate binding site [chemical binding]; other site 272943004884 ATP binding site [chemical binding]; other site 272943004885 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 272943004886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943004887 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 272943004888 NAD(P) binding site [chemical binding]; other site 272943004889 active site 272943004890 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272943004891 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 272943004892 Entericidin EcnA/B family; Region: Entericidin; cl02322 272943004893 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272943004894 MMPL family; Region: MMPL; cl14618 272943004895 MMPL family; Region: MMPL; cl14618 272943004896 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272943004897 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943004898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943004899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943004900 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 272943004901 catalytic residues [active] 272943004902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943004903 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 272943004904 putative substrate translocation pore; other site 272943004905 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272943004906 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272943004907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943004908 ATP binding site [chemical binding]; other site 272943004909 putative Mg++ binding site [ion binding]; other site 272943004910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943004911 nucleotide binding region [chemical binding]; other site 272943004912 ATP-binding site [chemical binding]; other site 272943004913 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272943004914 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 272943004915 dimer interface [polypeptide binding]; other site 272943004916 allosteric magnesium binding site [ion binding]; other site 272943004917 active site 272943004918 aspartate-rich active site metal binding site; other site 272943004919 Schiff base residues; other site 272943004920 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 272943004921 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272943004922 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272943004923 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 272943004924 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 272943004925 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 272943004926 active site 272943004927 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272943004928 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272943004929 HflX GTPase family; Region: HflX; cd01878 272943004930 G1 box; other site 272943004931 GTP/Mg2+ binding site [chemical binding]; other site 272943004932 Switch I region; other site 272943004933 G2 box; other site 272943004934 G3 box; other site 272943004935 Switch II region; other site 272943004936 G4 box; other site 272943004937 G5 box; other site 272943004938 bacterial Hfq-like; Region: Hfq; cd01716 272943004939 hexamer interface [polypeptide binding]; other site 272943004940 Sm1 motif; other site 272943004941 RNA binding site [nucleotide binding]; other site 272943004942 Sm2 motif; other site 272943004943 Cation transport protein; Region: TrkH; cl17365 272943004944 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272943004945 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 272943004946 TrkA-N domain; Region: TrkA_N; pfam02254 272943004947 TrkA-C domain; Region: TrkA_C; pfam02080 272943004948 TrkA-N domain; Region: TrkA_N; pfam02254 272943004949 TrkA-C domain; Region: TrkA_C; pfam02080 272943004950 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272943004951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004952 active site 272943004953 phosphorylation site [posttranslational modification] 272943004954 intermolecular recognition site; other site 272943004955 dimerization interface [polypeptide binding]; other site 272943004956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943004957 Walker A motif; other site 272943004958 ATP binding site [chemical binding]; other site 272943004959 Walker B motif; other site 272943004960 arginine finger; other site 272943004961 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943004962 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 272943004963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943004964 dimerization interface [polypeptide binding]; other site 272943004965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943004966 putative active site [active] 272943004967 heme pocket [chemical binding]; other site 272943004968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943004969 dimer interface [polypeptide binding]; other site 272943004970 phosphorylation site [posttranslational modification] 272943004971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943004972 ATP binding site [chemical binding]; other site 272943004973 Mg2+ binding site [ion binding]; other site 272943004974 G-X-G motif; other site 272943004975 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272943004976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943004977 active site 272943004978 phosphorylation site [posttranslational modification] 272943004979 intermolecular recognition site; other site 272943004980 dimerization interface [polypeptide binding]; other site 272943004981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943004982 Walker A motif; other site 272943004983 ATP binding site [chemical binding]; other site 272943004984 Walker B motif; other site 272943004985 arginine finger; other site 272943004986 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272943004987 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272943004988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943004989 putative active site [active] 272943004990 heme pocket [chemical binding]; other site 272943004991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943004992 dimer interface [polypeptide binding]; other site 272943004993 phosphorylation site [posttranslational modification] 272943004994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943004995 ATP binding site [chemical binding]; other site 272943004996 Mg2+ binding site [ion binding]; other site 272943004997 G-X-G motif; other site 272943004998 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272943004999 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272943005000 FMN binding site [chemical binding]; other site 272943005001 active site 272943005002 catalytic residues [active] 272943005003 substrate binding site [chemical binding]; other site 272943005004 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272943005005 substrate binding site; other site 272943005006 dimer interface; other site 272943005007 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272943005008 homotrimer interaction site [polypeptide binding]; other site 272943005009 zinc binding site [ion binding]; other site 272943005010 CDP-binding sites; other site 272943005011 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272943005012 tetramer interfaces [polypeptide binding]; other site 272943005013 binuclear metal-binding site [ion binding]; other site 272943005014 Competence-damaged protein; Region: CinA; pfam02464 272943005015 Predicted flavoproteins [General function prediction only]; Region: COG2081 272943005016 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 272943005017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943005018 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 272943005019 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 272943005020 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 272943005021 homodimer interface [polypeptide binding]; other site 272943005022 Walker A motif; other site 272943005023 ATP binding site [chemical binding]; other site 272943005024 hydroxycobalamin binding site [chemical binding]; other site 272943005025 Walker B motif; other site 272943005026 NnrS protein; Region: NnrS; pfam05940 272943005027 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272943005028 dimer interface [polypeptide binding]; other site 272943005029 [2Fe-2S] cluster binding site [ion binding]; other site 272943005030 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 272943005031 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272943005032 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272943005033 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 272943005034 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272943005035 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 272943005036 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 272943005037 active site 272943005038 SAM binding site [chemical binding]; other site 272943005039 homodimer interface [polypeptide binding]; other site 272943005040 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 272943005041 active site 272943005042 SAM binding site [chemical binding]; other site 272943005043 homodimer interface [polypeptide binding]; other site 272943005044 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 272943005045 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 272943005046 active site 272943005047 putative homodimer interface [polypeptide binding]; other site 272943005048 SAM binding site [chemical binding]; other site 272943005049 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 272943005050 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 272943005051 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 272943005052 active site 272943005053 SAM binding site [chemical binding]; other site 272943005054 homodimer interface [polypeptide binding]; other site 272943005055 uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06136 272943005056 active site 272943005057 homodimer interface [polypeptide binding]; other site 272943005058 SAM binding site [chemical binding]; other site 272943005059 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 272943005060 active site 272943005061 SAM binding site [chemical binding]; other site 272943005062 homodimer interface [polypeptide binding]; other site 272943005063 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272943005064 active site 272943005065 dimer interface [polypeptide binding]; other site 272943005066 metal binding site [ion binding]; metal-binding site 272943005067 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272943005068 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272943005069 ADP binding site [chemical binding]; other site 272943005070 magnesium binding site [ion binding]; other site 272943005071 putative shikimate binding site; other site 272943005072 glycogen branching enzyme; Provisional; Region: PRK14705 272943005073 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272943005074 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272943005075 active site 272943005076 DNA binding site [nucleotide binding] 272943005077 Int/Topo IB signature motif; other site 272943005078 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 272943005079 Domain of unknown function DUF21; Region: DUF21; pfam01595 272943005080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272943005081 Transporter associated domain; Region: CorC_HlyC; smart01091 272943005082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272943005083 Helix-turn-helix domain; Region: HTH_38; pfam13936 272943005084 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 272943005085 Protein of unknown function (DUF330); Region: DUF330; cl01135 272943005086 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 272943005087 mce related protein; Region: MCE; pfam02470 272943005088 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272943005089 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272943005090 Walker A/P-loop; other site 272943005091 ATP binding site [chemical binding]; other site 272943005092 Q-loop/lid; other site 272943005093 ABC transporter signature motif; other site 272943005094 Walker B; other site 272943005095 D-loop; other site 272943005096 H-loop/switch region; other site 272943005097 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272943005098 anti sigma factor interaction site; other site 272943005099 regulatory phosphorylation site [posttranslational modification]; other site 272943005100 Permease; Region: Permease; pfam02405 272943005101 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272943005102 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272943005103 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272943005104 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272943005105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943005106 Walker A motif; other site 272943005107 ATP binding site [chemical binding]; other site 272943005108 Walker B motif; other site 272943005109 arginine finger; other site 272943005110 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272943005111 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272943005112 FMN binding site [chemical binding]; other site 272943005113 active site 272943005114 substrate binding site [chemical binding]; other site 272943005115 catalytic residue [active] 272943005116 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272943005117 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272943005118 multidrug efflux protein; Reviewed; Region: PRK09579 272943005119 MMPL family; Region: MMPL; cl14618 272943005120 MMPL family; Region: MMPL; cl14618 272943005121 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272943005122 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943005123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943005124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943005125 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272943005126 GAF domain; Region: GAF; pfam01590 272943005127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943005128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943005129 Walker A motif; other site 272943005130 ATP binding site [chemical binding]; other site 272943005131 Walker B motif; other site 272943005132 arginine finger; other site 272943005133 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943005134 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272943005135 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 272943005136 NAD binding site [chemical binding]; other site 272943005137 substrate binding site [chemical binding]; other site 272943005138 catalytic Zn binding site [ion binding]; other site 272943005139 structural Zn binding site [ion binding]; other site 272943005140 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272943005141 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272943005142 ring oligomerisation interface [polypeptide binding]; other site 272943005143 ATP/Mg binding site [chemical binding]; other site 272943005144 stacking interactions; other site 272943005145 hinge regions; other site 272943005146 Domain of unknown function DUF59; Region: DUF59; pfam01883 272943005147 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 272943005148 active site 272943005149 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272943005150 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 272943005151 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 272943005152 dimerization interface [polypeptide binding]; other site 272943005153 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 272943005154 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943005155 catalytic loop [active] 272943005156 iron binding site [ion binding]; other site 272943005157 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 272943005158 FAD binding pocket [chemical binding]; other site 272943005159 conserved FAD binding motif [chemical binding]; other site 272943005160 phosphate binding motif [ion binding]; other site 272943005161 beta-alpha-beta structure motif; other site 272943005162 NAD binding pocket [chemical binding]; other site 272943005163 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 272943005164 dimerization interface [polypeptide binding]; other site 272943005165 putative path to active site cavity [active] 272943005166 diiron center [ion binding]; other site 272943005167 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272943005168 structural tetrad; other site 272943005169 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272943005170 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 272943005171 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272943005172 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272943005173 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272943005174 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272943005175 active site 272943005176 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272943005177 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 272943005178 gating phenylalanine in ion channel; other site 272943005179 nuclear egress membrane protein; Provisional; Region: PHA03326 272943005180 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272943005181 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943005182 Walker A/P-loop; other site 272943005183 ATP binding site [chemical binding]; other site 272943005184 Q-loop/lid; other site 272943005185 ABC transporter signature motif; other site 272943005186 Walker B; other site 272943005187 D-loop; other site 272943005188 H-loop/switch region; other site 272943005189 TOBE domain; Region: TOBE; pfam03459 272943005190 TOBE domain; Region: TOBE_2; pfam08402 272943005191 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943005192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005193 dimer interface [polypeptide binding]; other site 272943005194 conserved gate region; other site 272943005195 putative PBP binding loops; other site 272943005196 ABC-ATPase subunit interface; other site 272943005197 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943005198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005199 dimer interface [polypeptide binding]; other site 272943005200 conserved gate region; other site 272943005201 putative PBP binding loops; other site 272943005202 ABC-ATPase subunit interface; other site 272943005203 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943005204 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272943005205 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272943005206 beta-galactosidase; Region: BGL; TIGR03356 272943005207 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272943005208 Glucokinase; Region: Glucokinase; cl17310 272943005209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272943005210 nucleotide binding site [chemical binding]; other site 272943005211 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 272943005212 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272943005213 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272943005214 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272943005215 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272943005216 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272943005217 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272943005218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 272943005219 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272943005220 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 272943005221 putative hydrophobic ligand binding site [chemical binding]; other site 272943005222 PAS fold; Region: PAS_7; pfam12860 272943005223 PAS fold; Region: PAS_7; pfam12860 272943005224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943005225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943005226 dimer interface [polypeptide binding]; other site 272943005227 phosphorylation site [posttranslational modification] 272943005228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943005229 ATP binding site [chemical binding]; other site 272943005230 Mg2+ binding site [ion binding]; other site 272943005231 G-X-G motif; other site 272943005232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943005233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943005234 active site 272943005235 phosphorylation site [posttranslational modification] 272943005236 intermolecular recognition site; other site 272943005237 dimerization interface [polypeptide binding]; other site 272943005238 Uncharacterized conserved protein [Function unknown]; Region: COG3287 272943005239 FIST N domain; Region: FIST; pfam08495 272943005240 FIST C domain; Region: FIST_C; pfam10442 272943005241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943005242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943005243 active site 272943005244 phosphorylation site [posttranslational modification] 272943005245 intermolecular recognition site; other site 272943005246 dimerization interface [polypeptide binding]; other site 272943005247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943005248 DNA binding residues [nucleotide binding] 272943005249 dimerization interface [polypeptide binding]; other site 272943005250 phosphoglucomutase; Region: PLN02307 272943005251 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 272943005252 substrate binding site [chemical binding]; other site 272943005253 dimer interface [polypeptide binding]; other site 272943005254 active site 272943005255 metal binding site [ion binding]; metal-binding site 272943005256 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 272943005257 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272943005258 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272943005259 active site 272943005260 catalytic site [active] 272943005261 glycogen synthase; Provisional; Region: glgA; PRK00654 272943005262 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272943005263 ADP-binding pocket [chemical binding]; other site 272943005264 homodimer interface [polypeptide binding]; other site 272943005265 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 272943005266 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272943005267 ligand binding site; other site 272943005268 oligomer interface; other site 272943005269 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272943005270 dimer interface [polypeptide binding]; other site 272943005271 N-terminal domain interface [polypeptide binding]; other site 272943005272 sulfate 1 binding site; other site 272943005273 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272943005274 homodimer interface [polypeptide binding]; other site 272943005275 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272943005276 active site pocket [active] 272943005277 Transcriptional regulator; Region: Rrf2; cl17282 272943005278 Rrf2 family protein; Region: rrf2_super; TIGR00738 272943005279 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 272943005280 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 272943005281 DNA binding residues [nucleotide binding] 272943005282 dimer interface [polypeptide binding]; other site 272943005283 copper binding site [ion binding]; other site 272943005284 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272943005285 metal-binding site [ion binding] 272943005286 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272943005287 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272943005288 metal-binding site [ion binding] 272943005289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272943005290 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272943005291 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272943005292 metal-binding site [ion binding] 272943005293 Nucleoside diphosphate kinase; Region: NDK; pfam00334 272943005294 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272943005295 active site 272943005296 multimer interface [polypeptide binding]; other site 272943005297 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272943005298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943005299 ABC transporter; Region: ABC_tran_2; pfam12848 272943005300 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943005301 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 272943005302 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272943005303 catalytic motif [active] 272943005304 Catalytic residue [active] 272943005305 DNA polymerase III subunit chi; Validated; Region: PRK05728 272943005306 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272943005307 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272943005308 interface (dimer of trimers) [polypeptide binding]; other site 272943005309 Substrate-binding/catalytic site; other site 272943005310 Zn-binding sites [ion binding]; other site 272943005311 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272943005312 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272943005313 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 272943005314 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272943005315 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272943005316 SurA N-terminal domain; Region: SurA_N; pfam09312 272943005317 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272943005318 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 272943005319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943005320 S-adenosylmethionine binding site [chemical binding]; other site 272943005321 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 272943005322 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272943005323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943005324 S-adenosylmethionine binding site [chemical binding]; other site 272943005325 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272943005326 PCRF domain; Region: PCRF; pfam03462 272943005327 RF-1 domain; Region: RF-1; pfam00472 272943005328 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 272943005329 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 272943005330 oligomer interface [polypeptide binding]; other site 272943005331 putative active site [active] 272943005332 Mn binding site [ion binding]; other site 272943005333 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272943005334 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272943005335 metal binding site [ion binding]; metal-binding site 272943005336 putative dimer interface [polypeptide binding]; other site 272943005337 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 272943005338 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272943005339 homodimer interface [polypeptide binding]; other site 272943005340 metal binding site [ion binding]; metal-binding site 272943005341 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272943005342 homodimer interface [polypeptide binding]; other site 272943005343 active site 272943005344 putative chemical substrate binding site [chemical binding]; other site 272943005345 metal binding site [ion binding]; metal-binding site 272943005346 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272943005347 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 272943005348 active site 272943005349 tetramer interface [polypeptide binding]; other site 272943005350 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272943005351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943005352 dimer interface [polypeptide binding]; other site 272943005353 phosphorylation site [posttranslational modification] 272943005354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943005355 ATP binding site [chemical binding]; other site 272943005356 Mg2+ binding site [ion binding]; other site 272943005357 G-X-G motif; other site 272943005358 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943005359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943005360 catalytic residue [active] 272943005361 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272943005362 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272943005363 trimer interface [polypeptide binding]; other site 272943005364 putative metal binding site [ion binding]; other site 272943005365 Guanylate kinase; Region: Guanylate_kin; pfam00625 272943005366 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272943005367 catalytic site [active] 272943005368 G-X2-G-X-G-K; other site 272943005369 hypothetical protein; Provisional; Region: PRK11820 272943005370 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272943005371 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272943005372 PAS domain; Region: PAS_5; pfam07310 272943005373 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 272943005374 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272943005375 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 272943005376 conserved cys residue [active] 272943005377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943005378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943005379 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 272943005380 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 272943005381 putative ligand binding site [chemical binding]; other site 272943005382 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943005383 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272943005384 Walker A/P-loop; other site 272943005385 ATP binding site [chemical binding]; other site 272943005386 Q-loop/lid; other site 272943005387 ABC transporter signature motif; other site 272943005388 Walker B; other site 272943005389 D-loop; other site 272943005390 H-loop/switch region; other site 272943005391 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272943005392 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272943005393 Walker A/P-loop; other site 272943005394 ATP binding site [chemical binding]; other site 272943005395 Q-loop/lid; other site 272943005396 ABC transporter signature motif; other site 272943005397 Walker B; other site 272943005398 D-loop; other site 272943005399 H-loop/switch region; other site 272943005400 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272943005401 TM-ABC transporter signature motif; other site 272943005402 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272943005403 TM-ABC transporter signature motif; other site 272943005404 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 272943005405 Ligand binding site; other site 272943005406 metal-binding site 272943005407 Hint domain; Region: Hint_2; pfam13403 272943005408 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 272943005409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943005410 DNA-binding site [nucleotide binding]; DNA binding site 272943005411 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 272943005412 UTRA domain; Region: UTRA; pfam07702 272943005413 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 272943005414 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 272943005415 active site 272943005416 imidazolonepropionase; Validated; Region: PRK09356 272943005417 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272943005418 active site 272943005419 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 272943005420 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 272943005421 active sites [active] 272943005422 tetramer interface [polypeptide binding]; other site 272943005423 urocanate hydratase; Provisional; Region: PRK05414 272943005424 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 272943005425 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272943005426 active site 272943005427 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 272943005428 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 272943005429 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272943005430 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 272943005431 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272943005432 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272943005433 Sporulation related domain; Region: SPOR; pfam05036 272943005434 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 272943005435 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272943005436 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272943005437 active site 272943005438 HIGH motif; other site 272943005439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943005440 KMSK motif region; other site 272943005441 tRNA binding surface [nucleotide binding]; other site 272943005442 DALR anticodon binding domain; Region: DALR_1; smart00836 272943005443 anticodon binding site; other site 272943005444 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 272943005445 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 272943005446 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 272943005447 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 272943005448 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 272943005449 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272943005450 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 272943005451 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272943005452 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 272943005453 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272943005454 dimer interface [polypeptide binding]; other site 272943005455 PYR/PP interface [polypeptide binding]; other site 272943005456 TPP binding site [chemical binding]; other site 272943005457 substrate binding site [chemical binding]; other site 272943005458 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272943005459 TPP-binding site [chemical binding]; other site 272943005460 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 272943005461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943005462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943005463 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272943005464 putative effector binding pocket; other site 272943005465 dimerization interface [polypeptide binding]; other site 272943005466 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272943005467 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272943005468 dimerization interface [polypeptide binding]; other site 272943005469 ATP binding site [chemical binding]; other site 272943005470 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272943005471 dimerization interface [polypeptide binding]; other site 272943005472 ATP binding site [chemical binding]; other site 272943005473 BolA-like protein; Region: BolA; pfam01722 272943005474 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272943005475 putative GSH binding site [chemical binding]; other site 272943005476 catalytic residues [active] 272943005477 Cell division protein ZapA; Region: ZapA; pfam05164 272943005478 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272943005479 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272943005480 TPP-binding site [chemical binding]; other site 272943005481 dimer interface [polypeptide binding]; other site 272943005482 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272943005483 PYR/PP interface [polypeptide binding]; other site 272943005484 dimer interface [polypeptide binding]; other site 272943005485 TPP binding site [chemical binding]; other site 272943005486 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272943005487 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 272943005488 Protein of unknown function (DUF808); Region: DUF808; cl01002 272943005489 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272943005490 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272943005491 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272943005492 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272943005493 active site 272943005494 (T/H)XGH motif; other site 272943005495 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 272943005496 FOG: CBS domain [General function prediction only]; Region: COG0517 272943005497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943005498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943005499 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272943005500 dimerization interface [polypeptide binding]; other site 272943005501 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 272943005502 tetrameric interface [polypeptide binding]; other site 272943005503 NAD binding site [chemical binding]; other site 272943005504 catalytic residues [active] 272943005505 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943005506 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943005507 ligand binding site [chemical binding]; other site 272943005508 flexible hinge region; other site 272943005509 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272943005510 putative switch regulator; other site 272943005511 non-specific DNA interactions [nucleotide binding]; other site 272943005512 DNA binding site [nucleotide binding] 272943005513 sequence specific DNA binding site [nucleotide binding]; other site 272943005514 putative cAMP binding site [chemical binding]; other site 272943005515 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 272943005516 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272943005517 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272943005518 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272943005519 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272943005520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943005521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943005522 putative substrate translocation pore; other site 272943005523 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272943005524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943005525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943005526 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272943005527 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 272943005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943005529 putative substrate translocation pore; other site 272943005530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943005531 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272943005532 Protein of unknown function; Region: DUF3971; pfam13116 272943005533 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272943005534 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272943005535 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272943005536 catalytic triad [active] 272943005537 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 272943005538 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272943005539 Peptidase family M23; Region: Peptidase_M23; pfam01551 272943005540 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 272943005541 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 272943005542 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272943005543 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272943005544 RF-1 domain; Region: RF-1; pfam00472 272943005545 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 272943005546 Transglycosylase; Region: Transgly; pfam00912 272943005547 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272943005548 AMIN domain; Region: AMIN; pfam11741 272943005549 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272943005550 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272943005551 active site 272943005552 metal binding site [ion binding]; metal-binding site 272943005553 aspartate aminotransferase; Provisional; Region: PRK05764 272943005554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943005555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943005556 homodimer interface [polypeptide binding]; other site 272943005557 catalytic residue [active] 272943005558 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272943005559 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272943005560 catalytic residues [active] 272943005561 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272943005562 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 272943005563 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272943005564 Helix-turn-helix domain; Region: HTH_25; pfam13413 272943005565 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272943005566 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272943005567 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272943005568 substrate-cofactor binding pocket; other site 272943005569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943005570 catalytic residue [active] 272943005571 hypothetical protein; Validated; Region: PRK09104 272943005572 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 272943005573 metal binding site [ion binding]; metal-binding site 272943005574 putative dimer interface [polypeptide binding]; other site 272943005575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272943005576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943005577 Coenzyme A binding pocket [chemical binding]; other site 272943005578 Pirin-related protein [General function prediction only]; Region: COG1741 272943005579 Pirin; Region: Pirin; pfam02678 272943005580 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272943005581 Putative phage tail protein; Region: Phage-tail_3; pfam13550 272943005582 HNH endonuclease; Region: HNH_3; pfam13392 272943005583 AP2 domain; Region: AP2; pfam00847 272943005584 Phage major tail protein 2; Region: Phage_tail_2; cl11463 272943005585 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272943005586 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 272943005587 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272943005588 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272943005589 oligomerization interface [polypeptide binding]; other site 272943005590 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272943005591 Phage capsid family; Region: Phage_capsid; pfam05065 272943005592 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 272943005593 Phage portal protein; Region: Phage_portal; pfam04860 272943005594 Phage Terminase; Region: Terminase_1; cl19862 272943005595 HNH endonuclease; Region: HNH_3; pfam13392 272943005596 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 272943005597 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943005598 active site 272943005599 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 272943005600 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 272943005601 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272943005602 Catalytic site [active] 272943005603 H-NS histone family; Region: Histone_HNS; pfam00816 272943005604 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 272943005605 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272943005606 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272943005607 catalytic residues [active] 272943005608 catalytic nucleophile [active] 272943005609 Recombinase; Region: Recombinase; pfam07508 272943005610 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272943005611 GMP synthase; Reviewed; Region: guaA; PRK00074 272943005612 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272943005613 AMP/PPi binding site [chemical binding]; other site 272943005614 candidate oxyanion hole; other site 272943005615 catalytic triad [active] 272943005616 potential glutamine specificity residues [chemical binding]; other site 272943005617 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272943005618 ATP Binding subdomain [chemical binding]; other site 272943005619 Ligand Binding sites [chemical binding]; other site 272943005620 Dimerization subdomain; other site 272943005621 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943005622 EamA-like transporter family; Region: EamA; pfam00892 272943005623 EamA-like transporter family; Region: EamA; pfam00892 272943005624 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 272943005625 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943005626 EamA-like transporter family; Region: EamA; pfam00892 272943005627 EamA-like transporter family; Region: EamA; pfam00892 272943005628 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272943005629 proposed active site lysine [active] 272943005630 conserved cys residue [active] 272943005631 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943005632 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943005633 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 272943005634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943005635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943005636 WHG domain; Region: WHG; pfam13305 272943005637 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943005638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943005639 Walker A/P-loop; other site 272943005640 ATP binding site [chemical binding]; other site 272943005641 Q-loop/lid; other site 272943005642 ABC transporter signature motif; other site 272943005643 Walker B; other site 272943005644 D-loop; other site 272943005645 H-loop/switch region; other site 272943005646 TOBE domain; Region: TOBE_2; pfam08402 272943005647 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943005648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005649 dimer interface [polypeptide binding]; other site 272943005650 conserved gate region; other site 272943005651 putative PBP binding loops; other site 272943005652 ABC-ATPase subunit interface; other site 272943005653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005654 dimer interface [polypeptide binding]; other site 272943005655 conserved gate region; other site 272943005656 putative PBP binding loops; other site 272943005657 ABC-ATPase subunit interface; other site 272943005658 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272943005659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943005660 DNA-binding site [nucleotide binding]; DNA binding site 272943005661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943005662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943005663 homodimer interface [polypeptide binding]; other site 272943005664 catalytic residue [active] 272943005665 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 272943005666 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 272943005667 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272943005668 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272943005669 23S rRNA interface [nucleotide binding]; other site 272943005670 L3 interface [polypeptide binding]; other site 272943005671 SseB protein N-terminal domain; Region: SseB; pfam07179 272943005672 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 272943005673 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 272943005674 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 272943005675 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 272943005676 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272943005677 extended (e) SDRs; Region: SDR_e; cd08946 272943005678 NAD(P) binding site [chemical binding]; other site 272943005679 active site 272943005680 substrate binding site [chemical binding]; other site 272943005681 short chain dehydrogenase; Provisional; Region: PRK07109 272943005682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943005683 NAD(P) binding site [chemical binding]; other site 272943005684 active site 272943005685 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 272943005686 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 272943005687 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 272943005688 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272943005689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943005690 putative active site [active] 272943005691 heme pocket [chemical binding]; other site 272943005692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943005693 putative active site [active] 272943005694 heme pocket [chemical binding]; other site 272943005695 PAS domain S-box; Region: sensory_box; TIGR00229 272943005696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943005697 putative active site [active] 272943005698 heme pocket [chemical binding]; other site 272943005699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943005700 metal binding site [ion binding]; metal-binding site 272943005701 active site 272943005702 I-site; other site 272943005703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943005704 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 272943005705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943005706 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272943005707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943005708 DNA binding residues [nucleotide binding] 272943005709 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 272943005710 FHIPEP family; Region: FHIPEP; pfam00771 272943005711 LPP20 lipoprotein; Region: LPP20; pfam02169 272943005712 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; cl12363 272943005713 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272943005714 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 272943005715 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 272943005716 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272943005717 Sel1-like repeats; Region: SEL1; smart00671 272943005718 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 272943005719 Flagellar protein FliS; Region: FliS; cl00654 272943005720 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272943005721 putative binding surface; other site 272943005722 active site 272943005723 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272943005724 CheW-like domain; Region: CheW; pfam01584 272943005725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943005726 active site 272943005727 phosphorylation site [posttranslational modification] 272943005728 intermolecular recognition site; other site 272943005729 dimerization interface [polypeptide binding]; other site 272943005730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272943005731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272943005732 dimer interface [polypeptide binding]; other site 272943005733 putative CheW interface [polypeptide binding]; other site 272943005734 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272943005735 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943005736 P-loop; other site 272943005737 Magnesium ion binding site [ion binding]; other site 272943005738 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272943005739 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272943005740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943005741 active site 272943005742 phosphorylation site [posttranslational modification] 272943005743 intermolecular recognition site; other site 272943005744 dimerization interface [polypeptide binding]; other site 272943005745 CheB methylesterase; Region: CheB_methylest; pfam01339 272943005746 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272943005747 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272943005748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943005749 S-adenosylmethionine binding site [chemical binding]; other site 272943005750 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272943005751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943005752 ATP binding site [chemical binding]; other site 272943005753 Mg2+ binding site [ion binding]; other site 272943005754 G-X-G motif; other site 272943005755 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 272943005756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943005757 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272943005758 Walker A motif; other site 272943005759 ATP binding site [chemical binding]; other site 272943005760 Walker B motif; other site 272943005761 arginine finger; other site 272943005762 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 272943005763 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272943005764 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 272943005765 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272943005766 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272943005767 FliG N-terminal domain; Region: FliG_N; pfam14842 272943005768 FliG middle domain; Region: FliG_M; pfam14841 272943005769 FliG C-terminal domain; Region: FliG_C; pfam01706 272943005770 Flagellar assembly protein FliH; Region: FliH; cl19405 272943005771 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 272943005772 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943005773 Walker A motif; other site 272943005774 ATP binding site [chemical binding]; other site 272943005775 Walker B motif; other site 272943005776 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272943005777 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 272943005778 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 272943005779 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272943005780 flagellar motor switch protein FliN; Region: fliN; TIGR02480 272943005781 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 272943005782 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272943005783 flagellar biosynthetic protein FliQ; Region: fliQ; TIGR01402 272943005784 flagellar biosynthetic protein FliR; Region: fliR; TIGR01400 272943005785 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 272943005786 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272943005787 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272943005788 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272943005789 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272943005790 flagellin; Reviewed; Region: PRK08869 272943005791 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272943005792 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 272943005793 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272943005794 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 272943005795 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 272943005796 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 272943005797 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 272943005798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943005799 Walker A motif; other site 272943005800 ATP binding site [chemical binding]; other site 272943005801 Walker B motif; other site 272943005802 arginine finger; other site 272943005803 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943005804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943005805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943005806 catalytic residue [active] 272943005807 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272943005808 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 272943005809 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272943005810 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 272943005811 Rod binding protein; Region: Rod-binding; pfam10135 272943005812 Flagellar P-ring protein; Region: FlgI; pfam02119 272943005813 Flagellar L-ring protein; Region: FlgH; pfam02107 272943005814 flagellar basal-body rod protein FlgG, Gram-negative bacteria; Region: flgG_G_neg; TIGR02488 272943005815 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272943005816 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272943005817 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943005818 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 272943005819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943005820 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 272943005821 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 272943005822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943005823 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 272943005824 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272943005825 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 272943005826 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 272943005827 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272943005828 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943005829 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272943005830 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 272943005831 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 272943005832 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272943005833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943005834 putative active site [active] 272943005835 heme pocket [chemical binding]; other site 272943005836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943005837 dimer interface [polypeptide binding]; other site 272943005838 phosphorylation site [posttranslational modification] 272943005839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943005840 ATP binding site [chemical binding]; other site 272943005841 Mg2+ binding site [ion binding]; other site 272943005842 G-X-G motif; other site 272943005843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943005844 active site 272943005845 phosphorylation site [posttranslational modification] 272943005846 intermolecular recognition site; other site 272943005847 dimerization interface [polypeptide binding]; other site 272943005848 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272943005849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943005850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943005851 active site 272943005852 phosphorylation site [posttranslational modification] 272943005853 intermolecular recognition site; other site 272943005854 dimerization interface [polypeptide binding]; other site 272943005855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943005856 DNA binding residues [nucleotide binding] 272943005857 dimerization interface [polypeptide binding]; other site 272943005858 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 272943005859 dimerization interface [polypeptide binding]; other site 272943005860 metal binding site [ion binding]; metal-binding site 272943005861 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272943005862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943005863 active site 272943005864 motif I; other site 272943005865 motif II; other site 272943005866 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272943005867 PCI domain; Region: PCI; cl02111 272943005868 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272943005869 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943005870 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272943005871 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943005872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005873 putative PBP binding loops; other site 272943005874 dimer interface [polypeptide binding]; other site 272943005875 ABC-ATPase subunit interface; other site 272943005876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943005877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005878 dimer interface [polypeptide binding]; other site 272943005879 conserved gate region; other site 272943005880 putative PBP binding loops; other site 272943005881 ABC-ATPase subunit interface; other site 272943005882 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272943005883 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943005884 Walker A/P-loop; other site 272943005885 ATP binding site [chemical binding]; other site 272943005886 Q-loop/lid; other site 272943005887 ABC transporter signature motif; other site 272943005888 Walker B; other site 272943005889 D-loop; other site 272943005890 H-loop/switch region; other site 272943005891 TOBE domain; Region: TOBE_2; pfam08402 272943005892 sorbitol dehydrogenase; Provisional; Region: PRK07067 272943005893 Sorbitol dehydrogenase (SDH), classical (c) SDR; Region: SDH_SDR_c; cd05363 272943005894 putative NAD(P) binding site [chemical binding]; other site 272943005895 active site 272943005896 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272943005897 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272943005898 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272943005899 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 272943005900 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 272943005901 DctM-like transporters; Region: DctM; pfam06808 272943005902 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 272943005903 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 272943005904 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272943005905 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 272943005906 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 272943005907 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 272943005908 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 272943005909 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272943005910 putative dimer interface [polypeptide binding]; other site 272943005911 [2Fe-2S] cluster binding site [ion binding]; other site 272943005912 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 272943005913 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272943005914 SLBB domain; Region: SLBB; pfam10531 272943005915 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 272943005916 NADH dehydrogenase subunit G; Validated; Region: PRK08166 272943005917 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943005918 catalytic loop [active] 272943005919 iron binding site [ion binding]; other site 272943005920 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272943005921 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272943005922 molybdopterin cofactor binding site; other site 272943005923 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272943005924 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272943005925 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272943005926 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 272943005927 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 272943005928 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 272943005929 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943005930 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272943005931 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943005932 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272943005933 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943005934 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272943005935 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 272943005936 putative active site [active] 272943005937 catalytic site [active] 272943005938 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 272943005939 putative active site [active] 272943005940 catalytic site [active] 272943005941 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 272943005942 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272943005943 Cytochrome c; Region: Cytochrom_C; cl11414 272943005944 Cytochrome c; Region: Cytochrom_C; cl11414 272943005945 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272943005946 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272943005947 D-pathway; other site 272943005948 Putative ubiquinol binding site [chemical binding]; other site 272943005949 Low-spin heme (heme b) binding site [chemical binding]; other site 272943005950 Putative water exit pathway; other site 272943005951 Binuclear center (heme o3/CuB) [ion binding]; other site 272943005952 K-pathway; other site 272943005953 Putative proton exit pathway; other site 272943005954 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 272943005955 Subunit I/III interface [polypeptide binding]; other site 272943005956 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 272943005957 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 272943005958 oligomer interface [polypeptide binding]; other site 272943005959 CuA binuclear center [ion binding]; other site 272943005960 Cytochrome c; Region: Cytochrom_C; pfam00034 272943005961 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272943005962 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272943005963 active site 272943005964 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943005965 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943005966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943005967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943005968 DNA binding residues [nucleotide binding] 272943005969 transcriptional regulator TraR; Provisional; Region: PRK13870 272943005970 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943005971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943005972 DNA binding residues [nucleotide binding] 272943005973 dimerization interface [polypeptide binding]; other site 272943005974 Autoinducer synthetase; Region: Autoind_synth; pfam00765 272943005975 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 272943005976 glucosyltransferase MdoH; Provisional; Region: PRK05454 272943005977 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272943005978 active site 272943005979 OpgC protein; Region: OpgC_C; pfam10129 272943005980 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272943005981 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272943005982 Walker A/P-loop; other site 272943005983 ATP binding site [chemical binding]; other site 272943005984 Q-loop/lid; other site 272943005985 ABC transporter signature motif; other site 272943005986 Walker B; other site 272943005987 D-loop; other site 272943005988 H-loop/switch region; other site 272943005989 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943005990 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 272943005991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943005992 dimer interface [polypeptide binding]; other site 272943005993 conserved gate region; other site 272943005994 putative PBP binding loops; other site 272943005995 ABC-ATPase subunit interface; other site 272943005996 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272943005997 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 272943005998 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272943005999 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272943006000 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272943006001 active site 272943006002 catalytic residues [active] 272943006003 DNA binding site [nucleotide binding] 272943006004 Int/Topo IB signature motif; other site 272943006005 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272943006006 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272943006007 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272943006008 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272943006009 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272943006010 trigger factor; Provisional; Region: tig; PRK01490 272943006011 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272943006012 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272943006013 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272943006014 Hint domain; Region: Hint_2; pfam13403 272943006015 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272943006016 putative substrate binding site [chemical binding]; other site 272943006017 putative ATP binding site [chemical binding]; other site 272943006018 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272943006019 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272943006020 glutamine synthetase; Provisional; Region: glnA; PRK09469 272943006021 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272943006022 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272943006023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943006024 active site 272943006025 phosphorylation site [posttranslational modification] 272943006026 intermolecular recognition site; other site 272943006027 dimerization interface [polypeptide binding]; other site 272943006028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943006029 Histidine kinase; Region: HisKA_2; pfam07568 272943006030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943006031 ATP binding site [chemical binding]; other site 272943006032 Mg2+ binding site [ion binding]; other site 272943006033 G-X-G motif; other site 272943006034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943006035 active site 272943006036 phosphorylation site [posttranslational modification] 272943006037 intermolecular recognition site; other site 272943006038 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943006039 dimerization interface [polypeptide binding]; other site 272943006040 CHASE3 domain; Region: CHASE3; pfam05227 272943006041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943006042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943006043 dimer interface [polypeptide binding]; other site 272943006044 phosphorylation site [posttranslational modification] 272943006045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943006046 ATP binding site [chemical binding]; other site 272943006047 Mg2+ binding site [ion binding]; other site 272943006048 G-X-G motif; other site 272943006049 MoxR-like ATPases [General function prediction only]; Region: COG0714 272943006050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943006051 Walker A motif; other site 272943006052 ATP binding site [chemical binding]; other site 272943006053 Walker B motif; other site 272943006054 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 272943006055 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272943006056 metal ion-dependent adhesion site (MIDAS); other site 272943006057 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272943006058 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 272943006059 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 272943006060 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 272943006061 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943006062 substrate binding site [chemical binding]; other site 272943006063 oxyanion hole (OAH) forming residues; other site 272943006064 trimer interface [polypeptide binding]; other site 272943006065 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 272943006066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943006067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272943006068 active site 272943006069 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 272943006070 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272943006071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943006072 active site 272943006073 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272943006074 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272943006075 NAD binding site [chemical binding]; other site 272943006076 homodimer interface [polypeptide binding]; other site 272943006077 active site 272943006078 substrate binding site [chemical binding]; other site 272943006079 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 272943006080 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943006081 NAD binding site [chemical binding]; other site 272943006082 putative substrate binding site 2 [chemical binding]; other site 272943006083 putative substrate binding site 1 [chemical binding]; other site 272943006084 active site 272943006085 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943006086 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272943006087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006088 dimer interface [polypeptide binding]; other site 272943006089 conserved gate region; other site 272943006090 putative PBP binding loops; other site 272943006091 ABC-ATPase subunit interface; other site 272943006092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006093 dimer interface [polypeptide binding]; other site 272943006094 conserved gate region; other site 272943006095 putative PBP binding loops; other site 272943006096 ABC-ATPase subunit interface; other site 272943006097 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272943006098 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 272943006099 Putative phosphatase (DUF442); Region: DUF442; cl17385 272943006100 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272943006101 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 272943006102 Na binding site [ion binding]; other site 272943006103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943006104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943006105 dimer interface [polypeptide binding]; other site 272943006106 phosphorylation site [posttranslational modification] 272943006107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943006108 ATP binding site [chemical binding]; other site 272943006109 Mg2+ binding site [ion binding]; other site 272943006110 G-X-G motif; other site 272943006111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943006112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943006113 active site 272943006114 phosphorylation site [posttranslational modification] 272943006115 intermolecular recognition site; other site 272943006116 dimerization interface [polypeptide binding]; other site 272943006117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943006118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943006119 non-specific DNA binding site [nucleotide binding]; other site 272943006120 salt bridge; other site 272943006121 sequence-specific DNA binding site [nucleotide binding]; other site 272943006122 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 272943006123 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272943006124 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272943006125 short chain dehydrogenase; Provisional; Region: PRK07063 272943006126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943006127 NAD(P) binding site [chemical binding]; other site 272943006128 active site 272943006129 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 272943006130 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272943006131 putative ligand binding site [chemical binding]; other site 272943006132 NAD binding site [chemical binding]; other site 272943006133 catalytic site [active] 272943006134 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 272943006135 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272943006136 FAD binding domain; Region: FAD_binding_4; pfam01565 272943006137 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272943006138 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272943006139 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943006140 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943006141 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 272943006142 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943006143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006144 dimer interface [polypeptide binding]; other site 272943006145 conserved gate region; other site 272943006146 putative PBP binding loops; other site 272943006147 ABC-ATPase subunit interface; other site 272943006148 phenylhydantoinase; Validated; Region: PRK08323 272943006149 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 272943006150 tetramer interface [polypeptide binding]; other site 272943006151 active site 272943006152 allantoate amidohydrolase; Reviewed; Region: PRK12893 272943006153 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272943006154 active site 272943006155 metal binding site [ion binding]; metal-binding site 272943006156 dimer interface [polypeptide binding]; other site 272943006157 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 272943006158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943006159 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 272943006160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943006161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943006162 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 272943006163 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 272943006164 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 272943006165 homodimer interface [polypeptide binding]; other site 272943006166 active site 272943006167 FMN binding site [chemical binding]; other site 272943006168 substrate binding site [chemical binding]; other site 272943006169 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272943006170 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272943006171 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 272943006172 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272943006173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272943006174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943006175 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272943006176 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272943006177 carboxyltransferase (CT) interaction site; other site 272943006178 biotinylation site [posttranslational modification]; other site 272943006179 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272943006180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272943006181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272943006182 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272943006183 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 272943006184 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 272943006185 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272943006186 mce related protein; Region: MCE; pfam02470 272943006187 NADH dehydrogenase; Validated; Region: PRK08183 272943006188 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272943006189 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272943006190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943006191 Walker A motif; other site 272943006192 ATP binding site [chemical binding]; other site 272943006193 Walker B motif; other site 272943006194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272943006195 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272943006196 oligomer interface [polypeptide binding]; other site 272943006197 active site residues [active] 272943006198 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272943006199 hypothetical protein; Provisional; Region: PRK11622 272943006200 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 272943006201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006202 dimer interface [polypeptide binding]; other site 272943006203 conserved gate region; other site 272943006204 putative PBP binding loops; other site 272943006205 ABC-ATPase subunit interface; other site 272943006206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943006207 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 272943006208 Walker A/P-loop; other site 272943006209 ATP binding site [chemical binding]; other site 272943006210 Q-loop/lid; other site 272943006211 ABC transporter signature motif; other site 272943006212 Walker B; other site 272943006213 D-loop; other site 272943006214 H-loop/switch region; other site 272943006215 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272943006216 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272943006217 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272943006218 HAMP domain; Region: HAMP; pfam00672 272943006219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943006220 dimer interface [polypeptide binding]; other site 272943006221 phosphorylation site [posttranslational modification] 272943006222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943006223 ATP binding site [chemical binding]; other site 272943006224 Mg2+ binding site [ion binding]; other site 272943006225 G-X-G motif; other site 272943006226 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272943006227 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 272943006228 Phage portal protein; Region: Phage_portal; cl19194 272943006229 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 272943006230 Phage capsid family; Region: Phage_capsid; pfam05065 272943006231 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272943006232 active site 272943006233 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272943006234 Phage Terminase; Region: Terminase_1; cl19862 272943006235 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 272943006236 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 272943006237 Walker A motif; other site 272943006238 NTP binding site [chemical binding]; other site 272943006239 hexamer interface [polypeptide binding]; other site 272943006240 Walker B motif; other site 272943006241 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 272943006242 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 272943006243 integrase; Provisional; Region: PRK09692 272943006244 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272943006245 active site 272943006246 Int/Topo IB signature motif; other site 272943006247 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272943006248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943006249 dimer interface [polypeptide binding]; other site 272943006250 putative CheW interface [polypeptide binding]; other site 272943006251 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272943006252 LabA_like proteins; Region: LabA_like/DUF88; cl10034 272943006253 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 272943006254 TerB-N; Region: TerB-N; pfam13208 272943006255 tellurite resistance protein terB; Region: terB; cd07176 272943006256 putative metal binding site [ion binding]; other site 272943006257 TerB-C domain; Region: TerB-C; pfam15615 272943006258 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 272943006259 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 272943006260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943006261 ATP binding site [chemical binding]; other site 272943006262 putative Mg++ binding site [ion binding]; other site 272943006263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943006264 nucleotide binding region [chemical binding]; other site 272943006265 ATP-binding site [chemical binding]; other site 272943006266 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 272943006267 EF-hand domain pair; Region: EF-hand_7; pfam13499 272943006268 Ca2+ binding site [ion binding]; other site 272943006269 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 272943006270 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 272943006271 malonyl-CoA binding site [chemical binding]; other site 272943006272 dimer interface [polypeptide binding]; other site 272943006273 active site 272943006274 product binding site; other site 272943006275 Phospholipid methyltransferase; Region: PEMT; cl17370 272943006276 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272943006277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943006278 putative substrate translocation pore; other site 272943006279 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 272943006280 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 272943006281 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 272943006282 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 272943006283 active site 272943006284 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272943006285 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 272943006286 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272943006287 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 272943006288 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943006289 ligand binding site [chemical binding]; other site 272943006290 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 272943006291 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 272943006292 heme-binding site [chemical binding]; other site 272943006293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943006294 dimer interface [polypeptide binding]; other site 272943006295 putative CheW interface [polypeptide binding]; other site 272943006296 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 272943006297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943006298 FeS/SAM binding site; other site 272943006299 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272943006300 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943006301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943006302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943006303 acetylornithine deacetylase; Provisional; Region: PRK07522 272943006304 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 272943006305 metal binding site [ion binding]; metal-binding site 272943006306 putative dimer interface [polypeptide binding]; other site 272943006307 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 272943006308 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 272943006309 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 272943006310 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272943006311 ligand binding site [chemical binding]; other site 272943006312 homodimer interface [polypeptide binding]; other site 272943006313 NAD(P) binding site [chemical binding]; other site 272943006314 trimer interface B [polypeptide binding]; other site 272943006315 trimer interface A [polypeptide binding]; other site 272943006316 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272943006317 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 272943006318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943006319 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943006320 catalytic residue [active] 272943006321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272943006322 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943006323 Peptidase C26; Region: Peptidase_C26; pfam07722 272943006324 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272943006325 catalytic triad [active] 272943006326 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272943006327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943006328 catalytic residue [active] 272943006329 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943006330 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943006331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943006332 Walker A/P-loop; other site 272943006333 ATP binding site [chemical binding]; other site 272943006334 Q-loop/lid; other site 272943006335 ABC transporter signature motif; other site 272943006336 Walker B; other site 272943006337 D-loop; other site 272943006338 H-loop/switch region; other site 272943006339 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272943006340 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 272943006341 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272943006342 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272943006343 elongation factor P; Validated; Region: PRK00529 272943006344 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272943006345 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272943006346 RNA binding site [nucleotide binding]; other site 272943006347 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272943006348 RNA binding site [nucleotide binding]; other site 272943006349 PACS-1 cytosolic sorting protein; Region: Pacs-1; pfam10254 272943006350 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272943006351 Outer membrane efflux protein; Region: OEP; pfam02321 272943006352 Outer membrane efflux protein; Region: OEP; pfam02321 272943006353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943006354 S-adenosylmethionine binding site [chemical binding]; other site 272943006355 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272943006356 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943006357 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 272943006358 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272943006359 TPP-binding site; other site 272943006360 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272943006361 PYR/PP interface [polypeptide binding]; other site 272943006362 dimer interface [polypeptide binding]; other site 272943006363 TPP binding site [chemical binding]; other site 272943006364 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272943006365 Intrinsic membrane protein PufX; Region: RhodobacterPufX; pfam11511 272943006366 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 272943006367 subunit H interface; other site 272943006368 subunit L interface; other site 272943006369 bacteriopheophytin binding site; other site 272943006370 carotenoid binding site; other site 272943006371 bacteriochlorophyll binding site; other site 272943006372 cytochrome C interface; other site 272943006373 quinone binding site; other site 272943006374 Fe binding site [ion binding]; other site 272943006375 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 272943006376 subunit M interface; other site 272943006377 subunit H interface; other site 272943006378 quinone binding site; other site 272943006379 bacteriopheophytin binding site; other site 272943006380 bacteriochlorophyll binding site; other site 272943006381 cytochrome C subunit interface; other site 272943006382 Fe binding site [ion binding]; other site 272943006383 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272943006384 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272943006385 transcriptional regulatory protein PufK; Provisional; Region: PRK14755 272943006386 PufQ cytochrome subunit; Region: PufQ; pfam05398 272943006387 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272943006388 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 272943006389 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 272943006390 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272943006391 Chlorophyllide reductase converts chlorophylls into bacteriochlorophylls by reducing the chlorin B-ring. This family contains the X subunit of this three-subunit enzyme. Sequence and structure similarity between bchX, protochlorophyllide reductase L...; Region: BchX; cd02033 272943006392 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 272943006393 P-loop; other site 272943006394 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 272943006395 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 272943006396 putative NAD(P) binding site [chemical binding]; other site 272943006397 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 272943006398 O-methyltransferase; Region: Methyltransf_2; pfam00891 272943006399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943006400 S-adenosylmethionine binding site [chemical binding]; other site 272943006401 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272943006402 substrate binding pocket [chemical binding]; other site 272943006403 chain length determination region; other site 272943006404 substrate-Mg2+ binding site; other site 272943006405 catalytic residues [active] 272943006406 aspartate-rich region 1; other site 272943006407 active site lid residues [active] 272943006408 aspartate-rich region 2; other site 272943006409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272943006410 phytoene desaturase; Region: crtI_fam; TIGR02734 272943006411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943006412 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 272943006413 TspO/MBR family; Region: TspO_MBR; pfam03073 272943006414 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272943006415 active site lid residues [active] 272943006416 substrate binding pocket [chemical binding]; other site 272943006417 catalytic residues [active] 272943006418 substrate-Mg2+ binding site; other site 272943006419 aspartate-rich region 1; other site 272943006420 aspartate-rich region 2; other site 272943006421 phytoene desaturase; Region: crtI_fam; TIGR02734 272943006422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943006423 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 272943006424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943006425 Walker A motif; other site 272943006426 ATP binding site [chemical binding]; other site 272943006427 Walker B motif; other site 272943006428 arginine finger; other site 272943006429 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 272943006430 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272943006431 metal ion-dependent adhesion site (MIDAS); other site 272943006432 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 272943006433 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943006434 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 272943006435 active site 272943006436 metal binding site [ion binding]; metal-binding site 272943006437 nudix motif; other site 272943006438 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 272943006439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943006440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943006441 putative substrate translocation pore; other site 272943006442 PUCC protein; Region: PUCC; pfam03209 272943006443 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958 272943006444 putative active site [active] 272943006445 bacteriochlorophyll 4-vinyl reductase; Region: BchJ; TIGR02019 272943006446 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 272943006447 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272943006448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943006449 FeS/SAM binding site; other site 272943006450 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 272943006451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943006452 putative active site [active] 272943006453 heme pocket [chemical binding]; other site 272943006454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943006455 putative active site [active] 272943006456 heme pocket [chemical binding]; other site 272943006457 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943006458 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272943006459 B12 binding site [chemical binding]; other site 272943006460 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943006461 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 272943006462 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 272943006463 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 272943006464 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272943006465 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 272943006466 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 272943006467 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272943006468 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 272943006469 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 272943006470 P-loop; other site 272943006471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943006472 S-adenosylmethionine binding site [chemical binding]; other site 272943006473 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 272943006474 PUCC protein; Region: PUCC; pfam03209 272943006475 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 272943006476 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cd00226 272943006477 subunit C interaction residues; other site 272943006478 subunit M interaction residues [polypeptide binding]; other site 272943006479 subunit L interaction residues [polypeptide binding]; other site 272943006480 putative proton transfer pathway, P1; other site 272943006481 putative proton transfer pathway, P2; other site 272943006482 Bacterial PH domain; Region: bPH_2; pfam03703 272943006483 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 272943006484 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 272943006485 diiron binding motif [ion binding]; other site 272943006486 putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055 272943006487 Cytochrome c; Region: Cytochrom_C; cl11414 272943006488 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 272943006489 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272943006490 Walker A/P-loop; other site 272943006491 ATP binding site [chemical binding]; other site 272943006492 Q-loop/lid; other site 272943006493 ABC transporter signature motif; other site 272943006494 Walker B; other site 272943006495 D-loop; other site 272943006496 H-loop/switch region; other site 272943006497 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 272943006498 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272943006499 Walker A/P-loop; other site 272943006500 ATP binding site [chemical binding]; other site 272943006501 Q-loop/lid; other site 272943006502 ABC transporter signature motif; other site 272943006503 Walker B; other site 272943006504 D-loop; other site 272943006505 H-loop/switch region; other site 272943006506 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272943006507 TM-ABC transporter signature motif; other site 272943006508 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272943006509 TM-ABC transporter signature motif; other site 272943006510 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 272943006511 putative ligand binding site [chemical binding]; other site 272943006512 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943006513 UreF; Region: UreF; cl19817 272943006514 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 272943006515 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 272943006516 dimer interface [polypeptide binding]; other site 272943006517 catalytic residues [active] 272943006518 urease subunit alpha; Reviewed; Region: ureC; PRK13207 272943006519 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272943006520 subunit interactions [polypeptide binding]; other site 272943006521 active site 272943006522 flap region; other site 272943006523 Cytochrome c; Region: Cytochrom_C; pfam00034 272943006524 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 272943006525 gamma-beta subunit interface [polypeptide binding]; other site 272943006526 alpha-beta subunit interface [polypeptide binding]; other site 272943006527 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272943006528 alpha-gamma subunit interface [polypeptide binding]; other site 272943006529 beta-gamma subunit interface [polypeptide binding]; other site 272943006530 UreD urease accessory protein; Region: UreD; pfam01774 272943006531 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272943006532 Phosphotransferase enzyme family; Region: APH; pfam01636 272943006533 active site 272943006534 ATP binding site [chemical binding]; other site 272943006535 substrate binding site [chemical binding]; other site 272943006536 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943006537 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943006538 inhibitor-cofactor binding pocket; inhibition site 272943006539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943006540 catalytic residue [active] 272943006541 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272943006542 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272943006543 PUCC protein; Region: PUCC; pfam03209 272943006544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943006545 putative substrate translocation pore; other site 272943006546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943006547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 272943006548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943006549 DNA binding residues [nucleotide binding] 272943006550 dimerization interface [polypeptide binding]; other site 272943006551 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 272943006552 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272943006553 NnrU protein; Region: NnrU; pfam07298 272943006554 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 272943006555 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 272943006556 metal ion-dependent adhesion site (MIDAS); other site 272943006557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943006558 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 272943006559 Walker A motif; other site 272943006560 ATP binding site [chemical binding]; other site 272943006561 Walker B motif; other site 272943006562 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 272943006563 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 272943006564 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272943006565 Putative water exit pathway; other site 272943006566 Binuclear center (active site) [active] 272943006567 K-pathway; other site 272943006568 Putative proton exit pathway; other site 272943006569 Cytochrome c; Region: Cytochrom_C; pfam00034 272943006570 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 272943006571 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 272943006572 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943006573 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943006574 ligand binding site [chemical binding]; other site 272943006575 flexible hinge region; other site 272943006576 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272943006577 putative switch regulator; other site 272943006578 non-specific DNA interactions [nucleotide binding]; other site 272943006579 DNA binding site [nucleotide binding] 272943006580 sequence specific DNA binding site [nucleotide binding]; other site 272943006581 putative cAMP binding site [chemical binding]; other site 272943006582 NnrS protein; Region: NnrS; pfam05940 272943006583 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272943006584 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943006585 metal binding site [ion binding]; metal-binding site 272943006586 active site 272943006587 I-site; other site 272943006588 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 272943006589 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 272943006590 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272943006591 DXD motif; other site 272943006592 PilZ domain; Region: PilZ; pfam07238 272943006593 PAS domain; Region: PAS_8; pfam13188 272943006594 PAS fold; Region: PAS_4; pfam08448 272943006595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943006596 metal binding site [ion binding]; metal-binding site 272943006597 active site 272943006598 I-site; other site 272943006599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943006600 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272943006601 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 272943006602 putative active site [active] 272943006603 putative metal binding site [ion binding]; other site 272943006604 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272943006605 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272943006606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943006607 S-adenosylmethionine binding site [chemical binding]; other site 272943006608 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272943006609 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 272943006610 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 272943006611 active site 272943006612 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272943006613 TM-ABC transporter signature motif; other site 272943006614 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272943006615 TM-ABC transporter signature motif; other site 272943006616 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272943006617 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943006618 Walker A/P-loop; other site 272943006619 ATP binding site [chemical binding]; other site 272943006620 Q-loop/lid; other site 272943006621 ABC transporter signature motif; other site 272943006622 Walker B; other site 272943006623 D-loop; other site 272943006624 H-loop/switch region; other site 272943006625 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272943006626 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 272943006627 putative ligand binding site [chemical binding]; other site 272943006628 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272943006629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006630 dimer interface [polypeptide binding]; other site 272943006631 conserved gate region; other site 272943006632 putative PBP binding loops; other site 272943006633 ABC-ATPase subunit interface; other site 272943006634 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943006635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006636 dimer interface [polypeptide binding]; other site 272943006637 conserved gate region; other site 272943006638 putative PBP binding loops; other site 272943006639 ABC-ATPase subunit interface; other site 272943006640 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 272943006641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943006642 Walker A/P-loop; other site 272943006643 ATP binding site [chemical binding]; other site 272943006644 Q-loop/lid; other site 272943006645 ABC transporter signature motif; other site 272943006646 Walker B; other site 272943006647 D-loop; other site 272943006648 H-loop/switch region; other site 272943006649 TOBE domain; Region: TOBE_2; pfam08402 272943006650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272943006651 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272943006652 active site 272943006653 catalytic tetrad [active] 272943006654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943006655 catalytic loop [active] 272943006656 iron binding site [ion binding]; other site 272943006657 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943006658 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272943006659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272943006660 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272943006661 protein binding site [polypeptide binding]; other site 272943006662 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272943006663 protein binding site [polypeptide binding]; other site 272943006664 HflC protein; Region: hflC; TIGR01932 272943006665 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 272943006666 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 272943006667 HflK protein; Region: hflK; TIGR01933 272943006668 glutathione reductase; Validated; Region: PRK06116 272943006669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943006670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943006671 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272943006672 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272943006673 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272943006674 active site 272943006675 dimer interface [polypeptide binding]; other site 272943006676 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 272943006677 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272943006678 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272943006679 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943006680 EamA-like transporter family; Region: EamA; pfam00892 272943006681 Thiamine pyrophosphokinase; Region: TPK; cd07995 272943006682 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 272943006683 active site 272943006684 dimerization interface [polypeptide binding]; other site 272943006685 thiamine binding site [chemical binding]; other site 272943006686 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 272943006687 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272943006688 GDP-binding site [chemical binding]; other site 272943006689 ACT binding site; other site 272943006690 IMP binding site; other site 272943006691 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 272943006692 CTP synthetase; Validated; Region: pyrG; PRK05380 272943006693 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272943006694 Catalytic site [active] 272943006695 active site 272943006696 UTP binding site [chemical binding]; other site 272943006697 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272943006698 active site 272943006699 putative oxyanion hole; other site 272943006700 catalytic triad [active] 272943006701 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 272943006702 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 272943006703 putative metal binding site [ion binding]; other site 272943006704 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272943006705 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272943006706 Walker A/P-loop; other site 272943006707 ATP binding site [chemical binding]; other site 272943006708 Q-loop/lid; other site 272943006709 ABC transporter signature motif; other site 272943006710 Walker B; other site 272943006711 D-loop; other site 272943006712 H-loop/switch region; other site 272943006713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272943006714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272943006715 substrate binding pocket [chemical binding]; other site 272943006716 membrane-bound complex binding site; other site 272943006717 hinge residues; other site 272943006718 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272943006719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006720 ABC-ATPase subunit interface; other site 272943006721 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 272943006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943006723 dimer interface [polypeptide binding]; other site 272943006724 conserved gate region; other site 272943006725 putative PBP binding loops; other site 272943006726 ABC-ATPase subunit interface; other site 272943006727 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272943006728 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272943006729 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272943006730 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272943006731 catalytic triad [active] 272943006732 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272943006733 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272943006734 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272943006735 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943006736 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943006737 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943006738 inhibitor-cofactor binding pocket; inhibition site 272943006739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943006740 catalytic residue [active] 272943006741 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 272943006742 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 272943006743 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 272943006744 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272943006745 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272943006746 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 272943006747 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943006748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943006749 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272943006750 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272943006751 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272943006752 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272943006753 active site 272943006754 dimer interface [polypeptide binding]; other site 272943006755 motif 1; other site 272943006756 motif 2; other site 272943006757 motif 3; other site 272943006758 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272943006759 anticodon binding site; other site 272943006760 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943006761 DNA-binding site [nucleotide binding]; DNA binding site 272943006762 RNA-binding motif; other site 272943006763 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272943006764 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 272943006765 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272943006766 folate binding site [chemical binding]; other site 272943006767 NADP+ binding site [chemical binding]; other site 272943006768 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272943006769 dimerization interface [polypeptide binding]; other site 272943006770 active site 272943006771 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272943006772 dimer interface [polypeptide binding]; other site 272943006773 active site 272943006774 metal binding site [ion binding]; metal-binding site 272943006775 glutathione binding site [chemical binding]; other site 272943006776 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272943006777 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272943006778 catalytic motif [active] 272943006779 Zn binding site [ion binding]; other site 272943006780 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272943006781 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272943006782 ATP cone domain; Region: ATP-cone; pfam03477 272943006783 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 272943006784 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272943006785 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272943006786 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 272943006787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943006788 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272943006789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943006790 DNA binding residues [nucleotide binding] 272943006791 DNA primase; Validated; Region: dnaG; PRK05667 272943006792 CHC2 zinc finger; Region: zf-CHC2; cl17510 272943006793 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272943006794 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272943006795 active site 272943006796 metal binding site [ion binding]; metal-binding site 272943006797 interdomain interaction site; other site 272943006798 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272943006799 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272943006800 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272943006801 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272943006802 NAD(P) binding site [chemical binding]; other site 272943006803 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 272943006804 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 272943006805 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272943006806 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272943006807 TadE-like protein; Region: TadE; pfam07811 272943006808 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 272943006809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943006810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943006811 homoserine dehydrogenase; Provisional; Region: PRK06349 272943006812 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272943006813 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272943006814 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272943006815 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272943006816 putative active site [active] 272943006817 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272943006818 DHH family; Region: DHH; pfam01368 272943006819 DHHA1 domain; Region: DHHA1; pfam02272 272943006820 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 272943006821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943006822 metal binding site [ion binding]; metal-binding site 272943006823 active site 272943006824 I-site; other site 272943006825 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 272943006826 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272943006827 putative ligand binding site [chemical binding]; other site 272943006828 putative NAD binding site [chemical binding]; other site 272943006829 catalytic site [active] 272943006830 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 272943006831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943006832 metal binding site [ion binding]; metal-binding site 272943006833 active site 272943006834 I-site; other site 272943006835 Heme NO binding; Region: HNOB; pfam07700 272943006836 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272943006837 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 272943006838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943006839 motif II; other site 272943006840 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 272943006841 response regulator PleD; Reviewed; Region: pleD; PRK09581 272943006842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943006843 active site 272943006844 phosphorylation site [posttranslational modification] 272943006845 intermolecular recognition site; other site 272943006846 dimerization interface [polypeptide binding]; other site 272943006847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943006848 metal binding site [ion binding]; metal-binding site 272943006849 active site 272943006850 I-site; other site 272943006851 Heavy-metal resistance; Region: Metal_resist; pfam13801 272943006852 dimer interface [polypeptide binding]; other site 272943006853 RNA polymerase sigma factor; Provisional; Region: PRK12524 272943006854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943006855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943006856 DNA binding residues [nucleotide binding] 272943006857 EF-hand domain pair; Region: EF-hand_8; cl17302 272943006858 EF-hand domain pair; Region: EF-hand_7; pfam13499 272943006859 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 272943006860 Ca2+ binding site [ion binding]; other site 272943006861 Protein of unknown function (DUF983); Region: DUF983; pfam06170 272943006862 NUDIX domain; Region: NUDIX; pfam00293 272943006863 nudix motif; other site 272943006864 Lipocalin-like domain; Region: Lipocalin_2; cl19222 272943006865 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272943006866 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272943006867 active site 272943006868 catalytic tetrad [active] 272943006869 Uncharacterized conserved protein [Function unknown]; Region: COG4544 272943006870 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 272943006871 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272943006872 active site 272943006873 HIGH motif; other site 272943006874 KMSKS motif; other site 272943006875 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272943006876 tRNA binding surface [nucleotide binding]; other site 272943006877 anticodon binding site; other site 272943006878 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 272943006879 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272943006880 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943006881 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943006882 ligand binding site [chemical binding]; other site 272943006883 flexible hinge region; other site 272943006884 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 272943006885 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272943006886 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943006887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943006888 Walker A/P-loop; other site 272943006889 ATP binding site [chemical binding]; other site 272943006890 Q-loop/lid; other site 272943006891 ABC transporter signature motif; other site 272943006892 Walker B; other site 272943006893 D-loop; other site 272943006894 H-loop/switch region; other site 272943006895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272943006896 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 272943006897 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272943006898 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272943006899 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943006900 catalytic residue [active] 272943006901 Yip1 domain; Region: Yip1; pfam04893 272943006902 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272943006903 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272943006904 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272943006905 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272943006906 Walker A/P-loop; other site 272943006907 ATP binding site [chemical binding]; other site 272943006908 Q-loop/lid; other site 272943006909 ABC transporter signature motif; other site 272943006910 Walker B; other site 272943006911 D-loop; other site 272943006912 H-loop/switch region; other site 272943006913 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 272943006914 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272943006915 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272943006916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943006917 catalytic residue [active] 272943006918 Transcriptional regulator; Region: Rrf2; cl17282 272943006919 Rrf2 family protein; Region: rrf2_super; TIGR00738 272943006920 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943006921 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272943006922 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943006923 HD domain; Region: HD_3; pfam13023 272943006924 isocitrate dehydrogenase; Validated; Region: PRK08299 272943006925 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272943006926 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272943006927 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272943006928 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272943006929 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272943006930 G1 box; other site 272943006931 putative GEF interaction site [polypeptide binding]; other site 272943006932 GTP/Mg2+ binding site [chemical binding]; other site 272943006933 Switch I region; other site 272943006934 G2 box; other site 272943006935 G3 box; other site 272943006936 Switch II region; other site 272943006937 G4 box; other site 272943006938 G5 box; other site 272943006939 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272943006940 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272943006941 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272943006942 putative active site [active] 272943006943 putative dimer interface [polypeptide binding]; other site 272943006944 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 272943006945 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272943006946 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272943006947 motif 1; other site 272943006948 active site 272943006949 motif 2; other site 272943006950 motif 3; other site 272943006951 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272943006952 recombinase A; Provisional; Region: recA; PRK09354 272943006953 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272943006954 hexamer interface [polypeptide binding]; other site 272943006955 Walker A motif; other site 272943006956 ATP binding site [chemical binding]; other site 272943006957 Walker B motif; other site 272943006958 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272943006959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943006960 dimer interface [polypeptide binding]; other site 272943006961 phosphorylation site [posttranslational modification] 272943006962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943006963 ATP binding site [chemical binding]; other site 272943006964 Mg2+ binding site [ion binding]; other site 272943006965 G-X-G motif; other site 272943006966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943006967 active site 272943006968 phosphorylation site [posttranslational modification] 272943006969 intermolecular recognition site; other site 272943006970 dimerization interface [polypeptide binding]; other site 272943006971 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 272943006972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943006973 S-adenosylmethionine binding site [chemical binding]; other site 272943006974 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272943006975 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272943006976 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272943006977 RES domain; Region: RES; smart00953 272943006978 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 272943006979 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 272943006980 hypothetical protein; Provisional; Region: PRK14013 272943006981 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272943006982 MMPL family; Region: MMPL; cl14618 272943006983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 272943006984 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272943006985 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943006986 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272943006987 putative protease; Provisional; Region: PRK15447 272943006988 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272943006989 SCP-2 sterol transfer family; Region: SCP2; cl01225 272943006990 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 272943006991 Flavoprotein; Region: Flavoprotein; cl19190 272943006992 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272943006993 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272943006994 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272943006995 AAA domain; Region: AAA_17; cl19128 272943006996 AAA domain; Region: AAA_33; pfam13671 272943006997 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272943006998 putative catalytic site [active] 272943006999 putative metal binding site [ion binding]; other site 272943007000 putative phosphate binding site [ion binding]; other site 272943007001 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 272943007002 PLD-like domain; Region: PLDc_2; pfam13091 272943007003 putative active site [active] 272943007004 catalytic site [active] 272943007005 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 272943007006 PLD-like domain; Region: PLDc_2; pfam13091 272943007007 putative active site [active] 272943007008 catalytic site [active] 272943007009 Cytochrome C' Region: Cytochrom_C_2; pfam01322 272943007010 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272943007011 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272943007012 intersubunit interface [polypeptide binding]; other site 272943007013 active site 272943007014 Zn2+ binding site [ion binding]; other site 272943007015 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943007016 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272943007017 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 272943007018 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272943007019 motif 1; other site 272943007020 dimer interface [polypeptide binding]; other site 272943007021 active site 272943007022 motif 2; other site 272943007023 motif 3; other site 272943007024 elongation factor P; Validated; Region: PRK00529 272943007025 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272943007026 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272943007027 RNA binding site [nucleotide binding]; other site 272943007028 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272943007029 RNA binding site [nucleotide binding]; other site 272943007030 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272943007031 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272943007032 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272943007033 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 272943007034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943007035 NAD(P) binding site [chemical binding]; other site 272943007036 active site 272943007037 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 272943007038 Cupin domain; Region: Cupin_2; cl17218 272943007039 DctM-like transporters; Region: DctM; pfam06808 272943007040 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272943007041 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272943007042 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272943007043 glucuronate isomerase; Reviewed; Region: PRK02925 272943007044 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943007045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943007046 DNA-binding site [nucleotide binding]; DNA binding site 272943007047 FCD domain; Region: FCD; pfam07729 272943007048 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272943007049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943007050 putative active site [active] 272943007051 heme pocket [chemical binding]; other site 272943007052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943007053 dimer interface [polypeptide binding]; other site 272943007054 phosphorylation site [posttranslational modification] 272943007055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943007056 ATP binding site [chemical binding]; other site 272943007057 Mg2+ binding site [ion binding]; other site 272943007058 G-X-G motif; other site 272943007059 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 272943007060 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 272943007061 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 272943007062 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 272943007063 Acylphosphatase; Region: Acylphosphatase; pfam00708 272943007064 HypF finger; Region: zf-HYPF; pfam07503 272943007065 HypF finger; Region: zf-HYPF; pfam07503 272943007066 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272943007067 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 272943007068 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 272943007069 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 272943007070 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 272943007071 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 272943007072 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 272943007073 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 272943007074 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 272943007075 putative substrate-binding site; other site 272943007076 nickel binding site [ion binding]; other site 272943007077 HupF/HypC family; Region: HupF_HypC; pfam01455 272943007078 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 272943007079 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 272943007080 Rubredoxin [Energy production and conversion]; Region: COG1773 272943007081 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272943007082 iron binding site [ion binding]; other site 272943007083 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 272943007084 hypothetical protein; Provisional; Region: PRK06148 272943007085 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 272943007086 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272943007087 G1 box; other site 272943007088 GTP/Mg2+ binding site [chemical binding]; other site 272943007089 G2 box; other site 272943007090 Switch I region; other site 272943007091 Switch II region; other site 272943007092 G4 box; other site 272943007093 G5 box; other site 272943007094 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272943007095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943007096 active site 272943007097 phosphorylation site [posttranslational modification] 272943007098 intermolecular recognition site; other site 272943007099 dimerization interface [polypeptide binding]; other site 272943007100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943007101 Walker A motif; other site 272943007102 ATP binding site [chemical binding]; other site 272943007103 Walker B motif; other site 272943007104 arginine finger; other site 272943007105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943007106 HupF/HypC family; Region: HupF_HypC; cl00394 272943007107 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 272943007108 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 272943007109 dimerization interface [polypeptide binding]; other site 272943007110 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 272943007111 ATP binding site [chemical binding]; other site 272943007112 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272943007113 active site residue [active] 272943007114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943007115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943007116 active site 272943007117 phosphorylation site [posttranslational modification] 272943007118 intermolecular recognition site; other site 272943007119 dimerization interface [polypeptide binding]; other site 272943007120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272943007121 dimerization interface [polypeptide binding]; other site 272943007122 DNA binding residues [nucleotide binding] 272943007123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943007124 PAS domain; Region: PAS_9; pfam13426 272943007125 putative active site [active] 272943007126 heme pocket [chemical binding]; other site 272943007127 PAS fold; Region: PAS_7; pfam12860 272943007128 histidine kinase; Provisional; Region: PRK13557 272943007129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943007130 putative active site [active] 272943007131 heme pocket [chemical binding]; other site 272943007132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943007133 dimer interface [polypeptide binding]; other site 272943007134 phosphorylation site [posttranslational modification] 272943007135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943007136 ATP binding site [chemical binding]; other site 272943007137 Mg2+ binding site [ion binding]; other site 272943007138 G-X-G motif; other site 272943007139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943007140 active site 272943007141 phosphorylation site [posttranslational modification] 272943007142 intermolecular recognition site; other site 272943007143 dimerization interface [polypeptide binding]; other site 272943007144 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 272943007145 active site 272943007146 catalytic residues [active] 272943007147 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943007148 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 272943007149 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943007150 NAD binding site [chemical binding]; other site 272943007151 putative substrate binding site 2 [chemical binding]; other site 272943007152 putative substrate binding site 1 [chemical binding]; other site 272943007153 active site 272943007154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272943007155 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272943007156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272943007157 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272943007158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943007159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272943007160 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272943007161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943007162 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943007163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943007164 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943007165 NAD(P) binding site [chemical binding]; other site 272943007166 active site 272943007167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943007168 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943007169 NAD(P) binding site [chemical binding]; other site 272943007170 active site 272943007171 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272943007172 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 272943007173 putative NAD(P) binding site [chemical binding]; other site 272943007174 catalytic Zn binding site [ion binding]; other site 272943007175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272943007176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 272943007177 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272943007178 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 272943007179 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 272943007180 putative DNA binding site [nucleotide binding]; other site 272943007181 putative homodimer interface [polypeptide binding]; other site 272943007182 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 272943007183 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 272943007184 putative DNA binding site [nucleotide binding]; other site 272943007185 putative homodimer interface [polypeptide binding]; other site 272943007186 Haemolysin-III related; Region: HlyIII; cl03831 272943007187 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 272943007188 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272943007189 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 272943007190 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272943007191 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272943007192 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 272943007193 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 272943007194 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 272943007195 active site 272943007196 catalytic residues [active] 272943007197 metal binding site [ion binding]; metal-binding site 272943007198 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272943007199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943007200 catalytic residue [active] 272943007201 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 272943007202 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272943007203 active site 272943007204 NifU-like domain; Region: NifU; pfam01106 272943007205 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272943007206 NifQ; Region: NifQ; pfam04891 272943007207 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 272943007208 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272943007209 probable nitrogen fixation protein; Region: TIGR02935 272943007210 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 272943007211 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272943007212 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 272943007213 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272943007214 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 272943007215 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 272943007216 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 272943007217 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 272943007218 MoFe protein beta/alpha subunit interactions; other site 272943007219 Beta subunit P cluster binding residues; other site 272943007220 MoFe protein beta subunit/Fe protein contacts; other site 272943007221 MoFe protein dimer/ dimer interactions; other site 272943007222 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272943007223 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 272943007224 MoFe protein alpha/beta subunit interactions; other site 272943007225 Alpha subunit P cluster binding residues; other site 272943007226 FeMoco binding residues [chemical binding]; other site 272943007227 MoFe protein alpha subunit/Fe protein contacts; other site 272943007228 MoFe protein dimer/ dimer interactions; other site 272943007229 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 272943007230 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 272943007231 Nucleotide-binding sites [chemical binding]; other site 272943007232 Walker A motif; other site 272943007233 Switch I region of nucleotide binding site; other site 272943007234 Fe4S4 binding sites [ion binding]; other site 272943007235 Switch II region of nucleotide binding site; other site 272943007236 SIR2-like domain; Region: SIR2_2; pfam13289 272943007237 NifT/FixU protein; Region: NifT; pfam06988 272943007238 NifZ domain; Region: NifZ; pfam04319 272943007239 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 272943007240 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 272943007241 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 272943007242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943007243 FeS/SAM binding site; other site 272943007244 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 272943007245 Nif-specific regulatory protein; Region: nifA; TIGR01817 272943007246 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272943007247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943007248 Walker A motif; other site 272943007249 ATP binding site [chemical binding]; other site 272943007250 Walker B motif; other site 272943007251 arginine finger; other site 272943007252 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943007253 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 272943007254 active site 272943007255 catalytic residue [active] 272943007256 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 272943007257 Sporulation related domain; Region: SPOR; pfam05036 272943007258 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272943007259 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272943007260 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272943007261 thymidylate kinase; Validated; Region: tmk; PRK00698 272943007262 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272943007263 TMP-binding site; other site 272943007264 ATP-binding site [chemical binding]; other site 272943007265 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 272943007266 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272943007267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943007268 Walker A motif; other site 272943007269 ATP binding site [chemical binding]; other site 272943007270 Walker B motif; other site 272943007271 arginine finger; other site 272943007272 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272943007273 heat shock protein HtpX; Provisional; Region: PRK01345 272943007274 Peptidase family M48; Region: Peptidase_M48; cl12018 272943007275 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272943007276 RuvA N terminal domain; Region: RuvA_N; pfam01330 272943007277 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272943007278 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272943007279 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272943007280 active site 272943007281 putative DNA-binding cleft [nucleotide binding]; other site 272943007282 dimer interface [polypeptide binding]; other site 272943007283 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 272943007284 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 272943007285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943007286 S-adenosylmethionine binding site [chemical binding]; other site 272943007287 methionine sulfoxide reductase A; Provisional; Region: PRK00058 272943007288 primosome assembly protein PriA; Validated; Region: PRK05580 272943007289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943007290 ATP binding site [chemical binding]; other site 272943007291 putative Mg++ binding site [ion binding]; other site 272943007292 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272943007293 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 272943007294 active site 272943007295 intersubunit interactions; other site 272943007296 catalytic residue [active] 272943007297 Protein of unknown function, DUF484; Region: DUF484; cl17449 272943007298 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272943007299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272943007300 active site 272943007301 DNA binding site [nucleotide binding] 272943007302 Int/Topo IB signature motif; other site 272943007303 EF-hand domain pair; Region: EF-hand_7; pfam13499 272943007304 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 272943007305 Ca2+ binding site [ion binding]; other site 272943007306 EF-hand domain pair; Region: EF-hand_7; pfam13499 272943007307 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 272943007308 Ca2+ binding site [ion binding]; other site 272943007309 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272943007310 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 272943007311 EamA-like transporter family; Region: EamA; cl17759 272943007312 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272943007313 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272943007314 active site 272943007315 DNA binding site [nucleotide binding] 272943007316 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 272943007317 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 272943007318 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943007319 active site 272943007320 HIGH motif; other site 272943007321 nucleotide binding site [chemical binding]; other site 272943007322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943007323 active site 272943007324 KMSKS motif; other site 272943007325 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272943007326 tRNA binding surface [nucleotide binding]; other site 272943007327 anticodon binding site; other site 272943007328 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272943007329 hypothetical protein; Provisional; Region: PRK05415 272943007330 YcjX-like family, DUF463; Region: DUF463; pfam04317 272943007331 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272943007332 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272943007333 dimerization interface 3.5A [polypeptide binding]; other site 272943007334 active site 272943007335 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272943007336 active site 272943007337 catalytic site [active] 272943007338 substrate binding site [chemical binding]; other site 272943007339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943007341 active site 272943007342 phosphorylation site [posttranslational modification] 272943007343 intermolecular recognition site; other site 272943007344 dimerization interface [polypeptide binding]; other site 272943007345 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 272943007346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943007347 ligand binding site [chemical binding]; other site 272943007348 flexible hinge region; other site 272943007349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 272943007350 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272943007351 metal binding triad; other site 272943007352 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 272943007353 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272943007354 Na binding site [ion binding]; other site 272943007355 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 272943007356 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272943007357 adenylate kinase; Reviewed; Region: adk; PRK00279 272943007358 AMP-binding site [chemical binding]; other site 272943007359 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272943007360 acetyl-CoA synthetase; Provisional; Region: PRK00174 272943007361 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 272943007362 active site 272943007363 CoA binding site [chemical binding]; other site 272943007364 acyl-activating enzyme (AAE) consensus motif; other site 272943007365 AMP binding site [chemical binding]; other site 272943007366 acetate binding site [chemical binding]; other site 272943007367 high affinity sulphate transporter 1; Region: sulP; TIGR00815 272943007368 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272943007369 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272943007370 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272943007371 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 272943007372 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 272943007373 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 272943007374 tellurite resistance protein terB; Region: terB; cd07176 272943007375 putative metal binding site [ion binding]; other site 272943007376 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 272943007377 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943007378 active site 272943007379 nucleotide binding site [chemical binding]; other site 272943007380 HIGH motif; other site 272943007381 KMSKS motif; other site 272943007382 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 272943007383 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272943007384 active site 272943007385 (T/H)XGH motif; other site 272943007386 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272943007387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943007388 ABC transporter; Region: ABC_tran_2; pfam12848 272943007389 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272943007390 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 272943007391 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 272943007392 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943007393 DNA-binding site [nucleotide binding]; DNA binding site 272943007394 RNA-binding motif; other site 272943007395 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943007396 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272943007397 choline-sulfatase; Region: chol_sulfatase; TIGR03417 272943007398 Sulfatase; Region: Sulfatase; pfam00884 272943007399 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 272943007400 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 272943007401 Lipocalin-like domain; Region: Lipocalin_2; cl19222 272943007402 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 272943007403 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272943007404 active site 272943007405 Zn binding site [ion binding]; other site 272943007406 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 272943007407 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272943007408 ATP binding site [chemical binding]; other site 272943007409 substrate interface [chemical binding]; other site 272943007410 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272943007411 trimer interface [polypeptide binding]; other site 272943007412 active site 272943007413 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272943007414 Flavoprotein; Region: Flavoprotein; cl19190 272943007415 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 272943007416 Protein of unknown function, DUF399; Region: DUF399; pfam04187 272943007417 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 272943007418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943007419 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 272943007420 DNA binding residues [nucleotide binding] 272943007421 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272943007422 homotrimer interface [polypeptide binding]; other site 272943007423 Walker A motif; other site 272943007424 GTP binding site [chemical binding]; other site 272943007425 Walker B motif; other site 272943007426 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272943007427 catalytic core [active] 272943007428 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272943007429 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272943007430 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 272943007431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943007432 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272943007433 DNA binding residues [nucleotide binding] 272943007434 SnoaL-like domain; Region: SnoaL_2; pfam12680 272943007435 Protein of unknown function (DUF789); Region: DUF789; pfam05623 272943007436 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272943007437 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272943007438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943007439 NAD(P) binding site [chemical binding]; other site 272943007440 active site 272943007441 Predicted transcriptional regulators [Transcription]; Region: COG1733 272943007442 dimerization interface [polypeptide binding]; other site 272943007443 putative DNA binding site [nucleotide binding]; other site 272943007444 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943007445 putative Zn2+ binding site [ion binding]; other site 272943007446 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272943007447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272943007448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943007449 Coenzyme A binding pocket [chemical binding]; other site 272943007450 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272943007451 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 272943007452 putative NAD(P) binding site [chemical binding]; other site 272943007453 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272943007454 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272943007455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943007456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943007457 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 272943007458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 272943007459 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272943007460 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272943007461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943007462 ATP binding site [chemical binding]; other site 272943007463 putative Mg++ binding site [ion binding]; other site 272943007464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943007465 nucleotide binding region [chemical binding]; other site 272943007466 ATP-binding site [chemical binding]; other site 272943007467 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272943007468 Part of AAA domain; Region: AAA_19; pfam13245 272943007469 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272943007470 Domain of unknown function (DUF329); Region: DUF329; pfam03884 272943007471 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 272943007472 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272943007473 RNA binding site [nucleotide binding]; other site 272943007474 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272943007475 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272943007476 active site 272943007477 dimer interface [polypeptide binding]; other site 272943007478 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272943007479 rRNA binding site [nucleotide binding]; other site 272943007480 predicted 30S ribosome binding site; other site 272943007481 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 272943007482 putative active site [active] 272943007483 catalytic triad [active] 272943007484 putative dimer interface [polypeptide binding]; other site 272943007485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272943007486 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 272943007487 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272943007488 active site 272943007489 hypothetical protein; Provisional; Region: PRK02853 272943007490 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272943007491 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272943007492 NAD binding site [chemical binding]; other site 272943007493 dimerization interface [polypeptide binding]; other site 272943007494 product binding site; other site 272943007495 substrate binding site [chemical binding]; other site 272943007496 zinc binding site [ion binding]; other site 272943007497 catalytic residues [active] 272943007498 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 272943007499 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272943007500 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272943007501 hinge; other site 272943007502 active site 272943007503 DctM-like transporters; Region: DctM; pfam06808 272943007504 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272943007505 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 272943007506 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943007507 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272943007508 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 272943007509 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272943007510 FAD dependent oxidoreductase; Region: DAO; pfam01266 272943007511 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 272943007512 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272943007513 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 272943007514 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272943007515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943007516 non-specific DNA binding site [nucleotide binding]; other site 272943007517 salt bridge; other site 272943007518 sequence-specific DNA binding site [nucleotide binding]; other site 272943007519 Cupin domain; Region: Cupin_2; pfam07883 272943007520 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943007521 EamA-like transporter family; Region: EamA; pfam00892 272943007522 EamA-like transporter family; Region: EamA; pfam00892 272943007523 MASE1; Region: MASE1; cl17823 272943007524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943007525 Histidine kinase; Region: HisKA_2; pfam07568 272943007526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943007527 ATP binding site [chemical binding]; other site 272943007528 Mg2+ binding site [ion binding]; other site 272943007529 G-X-G motif; other site 272943007530 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943007531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943007532 dimer interface [polypeptide binding]; other site 272943007533 conserved gate region; other site 272943007534 putative PBP binding loops; other site 272943007535 ABC-ATPase subunit interface; other site 272943007536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943007537 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272943007538 Walker A/P-loop; other site 272943007539 ATP binding site [chemical binding]; other site 272943007540 Q-loop/lid; other site 272943007541 ABC transporter signature motif; other site 272943007542 Walker B; other site 272943007543 D-loop; other site 272943007544 H-loop/switch region; other site 272943007545 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272943007546 NMT1/THI5 like; Region: NMT1; pfam09084 272943007547 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272943007548 dimer interface [polypeptide binding]; other site 272943007549 substrate binding site [chemical binding]; other site 272943007550 ATP binding site [chemical binding]; other site 272943007551 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272943007552 thiamine phosphate binding site [chemical binding]; other site 272943007553 active site 272943007554 pyrophosphate binding site [ion binding]; other site 272943007555 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272943007556 substrate binding site [chemical binding]; other site 272943007557 multimerization interface [polypeptide binding]; other site 272943007558 ATP binding site [chemical binding]; other site 272943007559 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272943007560 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943007561 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943007562 catalytic residue [active] 272943007563 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 272943007564 active site 272943007565 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272943007566 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272943007567 NAD binding site [chemical binding]; other site 272943007568 homodimer interface [polypeptide binding]; other site 272943007569 active site 272943007570 substrate binding site [chemical binding]; other site 272943007571 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272943007572 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 272943007573 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272943007574 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272943007575 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943007576 EamA-like transporter family; Region: EamA; pfam00892 272943007577 EamA-like transporter family; Region: EamA; pfam00892 272943007578 hypothetical protein; Validated; Region: PRK00110 272943007579 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 272943007580 transmembrane helices; other site 272943007581 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272943007582 TrkA-C domain; Region: TrkA_C; pfam02080 272943007583 TrkA-C domain; Region: TrkA_C; pfam02080 272943007584 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272943007585 putative active site [active] 272943007586 metal binding site [ion binding]; metal-binding site 272943007587 homodimer binding site [polypeptide binding]; other site 272943007588 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 272943007589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943007590 ATP binding site [chemical binding]; other site 272943007591 putative Mg++ binding site [ion binding]; other site 272943007592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943007593 nucleotide binding region [chemical binding]; other site 272943007594 ATP-binding site [chemical binding]; other site 272943007595 DEAD/H associated; Region: DEAD_assoc; pfam08494 272943007596 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272943007597 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 272943007598 putative active site [active] 272943007599 putative metal binding site [ion binding]; other site 272943007600 LytTr DNA-binding domain; Region: LytTR; smart00850 272943007601 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 272943007602 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272943007603 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272943007604 homodimer interface [polypeptide binding]; other site 272943007605 NADP binding site [chemical binding]; other site 272943007606 substrate binding site [chemical binding]; other site 272943007607 Chorismate mutase type II; Region: CM_2; smart00830 272943007608 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272943007609 Potassium binding sites [ion binding]; other site 272943007610 Cesium cation binding sites [ion binding]; other site 272943007611 FtsH Extracellular; Region: FtsH_ext; pfam06480 272943007612 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272943007613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943007614 Walker A motif; other site 272943007615 ATP binding site [chemical binding]; other site 272943007616 Walker B motif; other site 272943007617 arginine finger; other site 272943007618 Peptidase family M41; Region: Peptidase_M41; pfam01434 272943007619 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272943007620 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272943007621 Ligand Binding Site [chemical binding]; other site 272943007622 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272943007623 Tetratricopeptide repeat; Region: TPR_6; pfam13174 272943007624 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943007625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943007626 ligand binding site [chemical binding]; other site 272943007627 translocation protein TolB; Provisional; Region: tolB; PRK05137 272943007628 TolB amino-terminal domain; Region: TolB_N; pfam04052 272943007629 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272943007630 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272943007631 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272943007632 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272943007633 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272943007634 ribonuclease E; Reviewed; Region: rne; PRK10811 272943007635 TolR protein; Region: tolR; TIGR02801 272943007636 TolQ protein; Region: tolQ; TIGR02796 272943007637 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272943007638 active site 272943007639 DNA polymerase III subunit delta'; Validated; Region: PRK07471 272943007640 AAA domain; Region: AAA_22; pfam13401 272943007641 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272943007642 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272943007643 active site 272943007644 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272943007645 Predicted permeases [General function prediction only]; Region: COG0679 272943007646 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 272943007647 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272943007648 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272943007649 domain interfaces; other site 272943007650 active site 272943007651 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272943007652 substrate binding site [chemical binding]; other site 272943007653 active site 272943007654 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272943007655 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 272943007656 classical (c) SDRs; Region: SDR_c; cd05233 272943007657 NAD(P) binding site [chemical binding]; other site 272943007658 active site 272943007659 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 272943007660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943007661 S-adenosylmethionine binding site [chemical binding]; other site 272943007662 Uncharacterized conserved protein [Function unknown]; Region: COG2127 272943007663 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272943007664 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272943007665 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272943007666 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272943007667 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 272943007668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272943007669 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272943007670 metal-binding site [ion binding] 272943007671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272943007672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943007673 motif II; other site 272943007674 FixH; Region: FixH; pfam05751 272943007675 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 272943007676 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272943007677 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 272943007678 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 272943007679 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 272943007680 N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715 272943007681 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272943007682 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272943007683 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 272943007684 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 272943007685 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 272943007686 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272943007687 Low-spin heme binding site [chemical binding]; other site 272943007688 Putative water exit pathway; other site 272943007689 Binuclear center (active site) [active] 272943007690 Putative proton exit pathway; other site 272943007691 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943007692 Ligand Binding Site [chemical binding]; other site 272943007693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943007694 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943007695 ligand binding site [chemical binding]; other site 272943007696 flexible hinge region; other site 272943007697 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272943007698 putative switch regulator; other site 272943007699 non-specific DNA interactions [nucleotide binding]; other site 272943007700 DNA binding site [nucleotide binding] 272943007701 sequence specific DNA binding site [nucleotide binding]; other site 272943007702 putative cAMP binding site [chemical binding]; other site 272943007703 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 272943007704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943007705 FeS/SAM binding site; other site 272943007706 HemN C-terminal domain; Region: HemN_C; pfam06969 272943007707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943007708 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 272943007709 putative ADP-binding pocket [chemical binding]; other site 272943007710 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 272943007711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943007712 Walker A/P-loop; other site 272943007713 ATP binding site [chemical binding]; other site 272943007714 Q-loop/lid; other site 272943007715 ABC transporter signature motif; other site 272943007716 Walker B; other site 272943007717 D-loop; other site 272943007718 H-loop/switch region; other site 272943007719 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272943007720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943007721 Walker A/P-loop; other site 272943007722 ATP binding site [chemical binding]; other site 272943007723 Q-loop/lid; other site 272943007724 ABC transporter signature motif; other site 272943007725 Walker B; other site 272943007726 D-loop; other site 272943007727 H-loop/switch region; other site 272943007728 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 272943007729 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943007730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943007731 dimer interface [polypeptide binding]; other site 272943007732 conserved gate region; other site 272943007733 putative PBP binding loops; other site 272943007734 ABC-ATPase subunit interface; other site 272943007735 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 272943007736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943007737 dimer interface [polypeptide binding]; other site 272943007738 conserved gate region; other site 272943007739 putative PBP binding loops; other site 272943007740 ABC-ATPase subunit interface; other site 272943007741 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272943007742 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 272943007743 Cytochrome c2 [Energy production and conversion]; Region: COG3474 272943007744 prephenate dehydratase; Provisional; Region: PRK11899 272943007745 Prephenate dehydratase; Region: PDT; pfam00800 272943007746 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272943007747 putative L-Phe binding site [chemical binding]; other site 272943007748 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 272943007749 hydrophobic ligand binding site; other site 272943007750 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 272943007751 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 272943007752 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 272943007753 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 272943007754 putative NADH binding site [chemical binding]; other site 272943007755 putative active site [active] 272943007756 nudix motif; other site 272943007757 putative metal binding site [ion binding]; other site 272943007758 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 272943007759 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272943007760 active site 272943007761 metal binding site [ion binding]; metal-binding site 272943007762 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272943007763 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 272943007764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943007765 Walker A motif; other site 272943007766 ATP binding site [chemical binding]; other site 272943007767 Walker B motif; other site 272943007768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272943007769 arginine finger; other site 272943007770 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272943007771 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 272943007772 hypothetical protein; Validated; Region: PRK00153 272943007773 recombination protein RecR; Reviewed; Region: recR; PRK00076 272943007774 RecR protein; Region: RecR; pfam02132 272943007775 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272943007776 putative active site [active] 272943007777 putative metal-binding site [ion binding]; other site 272943007778 tetramer interface [polypeptide binding]; other site 272943007779 OpgC protein; Region: OpgC_C; cl17858 272943007780 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 272943007781 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 272943007782 B1 nucleotide binding pocket [chemical binding]; other site 272943007783 B2 nucleotide binding pocket [chemical binding]; other site 272943007784 CAS motifs; other site 272943007785 active site 272943007786 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 272943007787 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 272943007788 NAD(P) binding site [chemical binding]; other site 272943007789 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272943007790 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272943007791 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 272943007792 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272943007793 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272943007794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943007795 S-adenosylmethionine binding site [chemical binding]; other site 272943007796 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943007797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943007798 dimerization interface [polypeptide binding]; other site 272943007799 putative DNA binding site [nucleotide binding]; other site 272943007800 putative Zn2+ binding site [ion binding]; other site 272943007801 AsnC family; Region: AsnC_trans_reg; pfam01037 272943007802 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272943007803 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272943007804 hexamer interface [polypeptide binding]; other site 272943007805 ligand binding site [chemical binding]; other site 272943007806 putative active site [active] 272943007807 NAD(P) binding site [chemical binding]; other site 272943007808 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 272943007809 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272943007810 catalytic residues [active] 272943007811 argininosuccinate lyase; Provisional; Region: PRK00855 272943007812 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272943007813 active sites [active] 272943007814 tetramer interface [polypeptide binding]; other site 272943007815 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 272943007816 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272943007817 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272943007818 active site 272943007819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272943007820 substrate binding site [chemical binding]; other site 272943007821 catalytic residues [active] 272943007822 dimer interface [polypeptide binding]; other site 272943007823 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 272943007824 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272943007825 HrpZ; Region: Hairpins; pfam04877 272943007826 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 272943007827 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272943007828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943007829 Walker A/P-loop; other site 272943007830 ATP binding site [chemical binding]; other site 272943007831 Q-loop/lid; other site 272943007832 ABC transporter signature motif; other site 272943007833 Walker B; other site 272943007834 D-loop; other site 272943007835 H-loop/switch region; other site 272943007836 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272943007837 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272943007838 putative acyl-acceptor binding pocket; other site 272943007839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943007840 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272943007841 Coenzyme A binding pocket [chemical binding]; other site 272943007842 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 272943007843 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 272943007844 Walker A motif; other site 272943007845 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272943007846 GTP binding site; other site 272943007847 AzlC protein; Region: AzlC; pfam03591 272943007848 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 272943007849 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 272943007850 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272943007851 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 272943007852 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943007853 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272943007854 active site 272943007855 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 272943007856 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272943007857 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272943007858 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272943007859 putative acyltransferase; Provisional; Region: PRK05790 272943007860 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272943007861 dimer interface [polypeptide binding]; other site 272943007862 active site 272943007863 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 272943007864 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272943007865 NAD(P) binding site [chemical binding]; other site 272943007866 homotetramer interface [polypeptide binding]; other site 272943007867 homodimer interface [polypeptide binding]; other site 272943007868 active site 272943007869 Protein of unknown function (DUF465); Region: DUF465; cl01070 272943007870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943007871 S-adenosylmethionine binding site [chemical binding]; other site 272943007872 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 272943007873 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272943007874 substrate binding pocket [chemical binding]; other site 272943007875 chain length determination region; other site 272943007876 substrate-Mg2+ binding site; other site 272943007877 catalytic residues [active] 272943007878 aspartate-rich region 1; other site 272943007879 active site lid residues [active] 272943007880 aspartate-rich region 2; other site 272943007881 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 272943007882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943007883 Coenzyme A binding pocket [chemical binding]; other site 272943007884 Protein of unknown function, DUF481; Region: DUF481; pfam04338 272943007885 hypothetical protein; Provisional; Region: PTZ00378 272943007886 transcription antitermination factor NusB; Region: nusB; TIGR01951 272943007887 putative RNA binding site [nucleotide binding]; other site 272943007888 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272943007889 homopentamer interface [polypeptide binding]; other site 272943007890 active site 272943007891 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 272943007892 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 272943007893 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 272943007894 dimerization interface [polypeptide binding]; other site 272943007895 active site 272943007896 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272943007897 Lumazine binding domain; Region: Lum_binding; pfam00677 272943007898 Lumazine binding domain; Region: Lum_binding; pfam00677 272943007899 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 272943007900 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272943007901 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943007902 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 272943007903 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 272943007904 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272943007905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943007906 non-specific DNA binding site [nucleotide binding]; other site 272943007907 salt bridge; other site 272943007908 sequence-specific DNA binding site [nucleotide binding]; other site 272943007909 aspartate aminotransferase; Provisional; Region: PRK05764 272943007910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943007911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943007912 homodimer interface [polypeptide binding]; other site 272943007913 catalytic residue [active] 272943007914 multidrug efflux protein; Reviewed; Region: PRK01766 272943007915 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272943007916 cation binding site [ion binding]; other site 272943007917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943007918 S-adenosylmethionine binding site [chemical binding]; other site 272943007919 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 272943007920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943007921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943007922 DNA binding residues [nucleotide binding] 272943007923 dimerization interface [polypeptide binding]; other site 272943007924 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272943007925 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272943007926 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272943007927 putative C-terminal domain interface [polypeptide binding]; other site 272943007928 putative GSH binding site (G-site) [chemical binding]; other site 272943007929 putative dimer interface [polypeptide binding]; other site 272943007930 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 272943007931 dimer interface [polypeptide binding]; other site 272943007932 N-terminal domain interface [polypeptide binding]; other site 272943007933 putative substrate binding pocket (H-site) [chemical binding]; other site 272943007934 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272943007935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943007936 ATP binding site [chemical binding]; other site 272943007937 Mg2+ binding site [ion binding]; other site 272943007938 G-X-G motif; other site 272943007939 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272943007940 anchoring element; other site 272943007941 dimer interface [polypeptide binding]; other site 272943007942 ATP binding site [chemical binding]; other site 272943007943 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272943007944 active site 272943007945 metal binding site [ion binding]; metal-binding site 272943007946 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272943007947 mannonate dehydratase; Provisional; Region: PRK03906 272943007948 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 272943007949 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272943007950 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272943007951 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272943007952 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272943007953 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272943007954 RNA binding site [nucleotide binding]; other site 272943007955 Cytochrome c; Region: Cytochrom_C; cl11414 272943007956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272943007957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272943007958 Walker A/P-loop; other site 272943007959 ATP binding site [chemical binding]; other site 272943007960 Q-loop/lid; other site 272943007961 ABC transporter signature motif; other site 272943007962 Walker B; other site 272943007963 D-loop; other site 272943007964 H-loop/switch region; other site 272943007965 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 272943007966 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272943007967 FtsX-like permease family; Region: FtsX; pfam02687 272943007968 prolyl-tRNA synthetase; Provisional; Region: PRK12325 272943007969 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272943007970 dimer interface [polypeptide binding]; other site 272943007971 motif 1; other site 272943007972 active site 272943007973 motif 2; other site 272943007974 motif 3; other site 272943007975 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272943007976 anticodon binding site; other site 272943007977 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272943007978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272943007979 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272943007980 polyphosphate kinase; Provisional; Region: PRK05443 272943007981 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272943007982 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272943007983 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272943007984 putative domain interface [polypeptide binding]; other site 272943007985 putative active site [active] 272943007986 catalytic site [active] 272943007987 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272943007988 putative domain interface [polypeptide binding]; other site 272943007989 putative active site [active] 272943007990 catalytic site [active] 272943007991 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272943007992 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272943007993 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 272943007994 putative acetyltransferase; Provisional; Region: PRK03624 272943007995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943007996 Coenzyme A binding pocket [chemical binding]; other site 272943007997 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 272943007998 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 272943007999 putative metal binding site [ion binding]; other site 272943008000 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272943008001 HSP70 interaction site [polypeptide binding]; other site 272943008002 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272943008003 putative catalytic site [active] 272943008004 putative metal binding site [ion binding]; other site 272943008005 putative phosphate binding site [ion binding]; other site 272943008006 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 272943008007 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 272943008008 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 272943008009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943008010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943008011 homodimer interface [polypeptide binding]; other site 272943008012 catalytic residue [active] 272943008013 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 272943008014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943008015 FeS/SAM binding site; other site 272943008016 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272943008017 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 272943008018 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 272943008019 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 272943008020 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 272943008021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943008022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943008023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272943008024 dimerization interface [polypeptide binding]; other site 272943008025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 272943008026 cobyric acid synthase; Provisional; Region: PRK00784 272943008027 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943008028 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272943008029 catalytic triad [active] 272943008030 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 272943008031 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272943008032 active site 272943008033 nucleotide binding site [chemical binding]; other site 272943008034 HIGH motif; other site 272943008035 KMSKS motif; other site 272943008036 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 272943008037 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272943008038 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 272943008039 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 272943008040 active site 272943008041 Zn binding site [ion binding]; other site 272943008042 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 272943008043 active site 272943008044 dimer interface [polypeptide binding]; other site 272943008045 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272943008046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943008047 Walker A/P-loop; other site 272943008048 ATP binding site [chemical binding]; other site 272943008049 Q-loop/lid; other site 272943008050 ABC transporter signature motif; other site 272943008051 Walker B; other site 272943008052 D-loop; other site 272943008053 H-loop/switch region; other site 272943008054 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272943008055 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943008056 Walker A/P-loop; other site 272943008057 ATP binding site [chemical binding]; other site 272943008058 Q-loop/lid; other site 272943008059 ABC transporter signature motif; other site 272943008060 Walker B; other site 272943008061 D-loop; other site 272943008062 H-loop/switch region; other site 272943008063 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943008064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272943008065 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943008066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943008067 dimer interface [polypeptide binding]; other site 272943008068 conserved gate region; other site 272943008069 putative PBP binding loops; other site 272943008070 ABC-ATPase subunit interface; other site 272943008071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943008072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943008073 dimer interface [polypeptide binding]; other site 272943008074 conserved gate region; other site 272943008075 putative PBP binding loops; other site 272943008076 ABC-ATPase subunit interface; other site 272943008077 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943008078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 272943008079 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 272943008080 putative FMN binding site [chemical binding]; other site 272943008081 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 272943008082 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 272943008083 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 272943008084 dimer interface [polypeptide binding]; other site 272943008085 substrate binding site [chemical binding]; other site 272943008086 metal binding site [ion binding]; metal-binding site 272943008087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943008088 active site 272943008089 phosphorylation site [posttranslational modification] 272943008090 intermolecular recognition site; other site 272943008091 dimerization interface [polypeptide binding]; other site 272943008092 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272943008093 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272943008094 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272943008095 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272943008096 dimer interface [polypeptide binding]; other site 272943008097 anticodon binding site; other site 272943008098 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272943008099 motif 1; other site 272943008100 dimer interface [polypeptide binding]; other site 272943008101 active site 272943008102 motif 2; other site 272943008103 GAD domain; Region: GAD; pfam02938 272943008104 motif 3; other site 272943008105 hypothetical protein; Provisional; Region: PRK07546 272943008106 substrate-cofactor binding pocket; other site 272943008107 homodimer interface [polypeptide binding]; other site 272943008108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943008109 catalytic residue [active] 272943008110 aminodeoxychorismate synthase; Provisional; Region: PRK07508 272943008111 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272943008112 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272943008113 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272943008114 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272943008115 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 272943008116 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272943008117 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272943008118 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272943008119 IMP binding site; other site 272943008120 dimer interface [polypeptide binding]; other site 272943008121 partial ornithine binding site; other site 272943008122 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 272943008123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272943008124 ATP binding site [chemical binding]; other site 272943008125 Mg++ binding site [ion binding]; other site 272943008126 motif III; other site 272943008127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943008128 nucleotide binding region [chemical binding]; other site 272943008129 ATP-binding site [chemical binding]; other site 272943008130 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272943008131 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943008132 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943008133 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272943008134 dimer interface [polypeptide binding]; other site 272943008135 active site 272943008136 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272943008137 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272943008138 folate binding site [chemical binding]; other site 272943008139 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 272943008140 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272943008141 putative active site [active] 272943008142 catalytic residue [active] 272943008143 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272943008144 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 272943008145 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272943008146 5S rRNA interface [nucleotide binding]; other site 272943008147 CTC domain interface [polypeptide binding]; other site 272943008148 L16 interface [polypeptide binding]; other site 272943008149 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 272943008150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943008151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943008152 putative substrate translocation pore; other site 272943008153 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 272943008154 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 272943008155 active site 272943008156 substrate binding site [chemical binding]; other site 272943008157 FMN binding site [chemical binding]; other site 272943008158 putative catalytic residues [active] 272943008159 HPP family; Region: HPP; pfam04982 272943008160 FOG: CBS domain [General function prediction only]; Region: COG0517 272943008161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 272943008162 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272943008163 substrate binding site [chemical binding]; other site 272943008164 active site 272943008165 catalytic residues [active] 272943008166 heterodimer interface [polypeptide binding]; other site 272943008167 GTP-binding protein YchF; Reviewed; Region: PRK09601 272943008168 YchF GTPase; Region: YchF; cd01900 272943008169 G1 box; other site 272943008170 GTP/Mg2+ binding site [chemical binding]; other site 272943008171 Switch I region; other site 272943008172 G2 box; other site 272943008173 Switch II region; other site 272943008174 G3 box; other site 272943008175 G4 box; other site 272943008176 G5 box; other site 272943008177 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272943008178 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 272943008179 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272943008180 Substrate binding site; other site 272943008181 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 272943008182 phosphomannomutase CpsG; Provisional; Region: PRK15414 272943008183 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272943008184 active site 272943008185 substrate binding site [chemical binding]; other site 272943008186 metal binding site [ion binding]; metal-binding site 272943008187 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 272943008188 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 272943008189 active site 272943008190 catalytic residues [active] 272943008191 Predicted flavoproteins [General function prediction only]; Region: COG2081 272943008192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943008193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943008194 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 272943008195 Lipopolysaccharide-assembly; Region: LptE; pfam04390 272943008196 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272943008197 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272943008198 active site 272943008199 HIGH motif; other site 272943008200 KMSKS motif; other site 272943008201 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272943008202 tRNA binding surface [nucleotide binding]; other site 272943008203 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 272943008204 Gram-negative porin; Region: Porin_4; pfam13609 272943008205 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272943008206 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272943008207 catalytic residue [active] 272943008208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 272943008209 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272943008210 dimerization interface [polypeptide binding]; other site 272943008211 active site 272943008212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943008213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943008214 active site 272943008215 phosphorylation site [posttranslational modification] 272943008216 intermolecular recognition site; other site 272943008217 dimerization interface [polypeptide binding]; other site 272943008218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943008219 DNA binding site [nucleotide binding] 272943008220 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272943008221 putative catalytic site [active] 272943008222 putative phosphate binding site [ion binding]; other site 272943008223 active site 272943008224 metal binding site A [ion binding]; metal-binding site 272943008225 DNA binding site [nucleotide binding] 272943008226 putative AP binding site [nucleotide binding]; other site 272943008227 putative metal binding site B [ion binding]; other site 272943008228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943008229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943008230 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 272943008231 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 272943008232 diiron binding motif [ion binding]; other site 272943008233 CCC1-related protein family; Region: CCC1_like_1; cd02437 272943008234 Predicted permeases [General function prediction only]; Region: COG0679 272943008235 Predicted esterase [General function prediction only]; Region: COG0627 272943008236 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272943008237 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 272943008238 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 272943008239 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 272943008240 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 272943008241 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 272943008242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943008243 S-adenosylmethionine binding site [chemical binding]; other site 272943008244 EamA-like transporter family; Region: EamA; pfam00892 272943008245 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272943008246 EamA-like transporter family; Region: EamA; pfam00892 272943008247 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272943008248 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272943008249 putative catalytic site [active] 272943008250 putative phosphate binding site [ion binding]; other site 272943008251 putative metal binding site [ion binding]; other site 272943008252 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272943008253 substrate binding site [chemical binding]; other site 272943008254 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 272943008255 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272943008256 substrate binding site [chemical binding]; other site 272943008257 ligand binding site [chemical binding]; other site 272943008258 SOUL heme-binding protein; Region: SOUL; pfam04832 272943008259 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 272943008260 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272943008261 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272943008262 RNA/DNA hybrid binding site [nucleotide binding]; other site 272943008263 active site 272943008264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943008265 active site 272943008266 phosphorylation site [posttranslational modification] 272943008267 intermolecular recognition site; other site 272943008268 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272943008269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943008270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943008271 homodimer interface [polypeptide binding]; other site 272943008272 catalytic residue [active] 272943008273 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272943008274 active site 272943008275 catalytic residues [active] 272943008276 metal binding site [ion binding]; metal-binding site 272943008277 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272943008278 active site 272943008279 catalytic residues [active] 272943008280 metal binding site [ion binding]; metal-binding site 272943008281 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272943008282 active site 272943008283 catalytic residues [active] 272943008284 metal binding site [ion binding]; metal-binding site 272943008285 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272943008286 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272943008287 putative active site [active] 272943008288 substrate binding site [chemical binding]; other site 272943008289 putative cosubstrate binding site; other site 272943008290 catalytic site [active] 272943008291 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272943008292 substrate binding site [chemical binding]; other site 272943008293 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272943008294 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272943008295 Walker A/P-loop; other site 272943008296 ATP binding site [chemical binding]; other site 272943008297 Q-loop/lid; other site 272943008298 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 272943008299 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272943008300 ABC transporter signature motif; other site 272943008301 Walker B; other site 272943008302 D-loop; other site 272943008303 H-loop/switch region; other site 272943008304 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272943008305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943008306 Coenzyme A binding pocket [chemical binding]; other site 272943008307 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943008308 EamA-like transporter family; Region: EamA; pfam00892 272943008309 Uncharacterized conserved protein [Function unknown]; Region: COG4121 272943008310 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272943008311 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943008312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943008313 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272943008314 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272943008315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943008316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943008317 catalytic residue [active] 272943008318 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272943008319 dimer interface [polypeptide binding]; other site 272943008320 active site 272943008321 catalytic residue [active] 272943008322 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272943008323 SmpB-tmRNA interface; other site 272943008324 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272943008325 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272943008326 active site residue [active] 272943008327 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272943008328 active site residue [active] 272943008329 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272943008330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943008331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943008332 homodimer interface [polypeptide binding]; other site 272943008333 catalytic residue [active] 272943008334 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272943008335 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 272943008336 Transglycosylase; Region: Transgly; pfam00912 272943008337 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272943008338 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272943008339 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 272943008340 VacJ like lipoprotein; Region: VacJ; cl01073 272943008341 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 272943008342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943008343 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 272943008344 Walker A/P-loop; other site 272943008345 ATP binding site [chemical binding]; other site 272943008346 Q-loop/lid; other site 272943008347 ABC transporter signature motif; other site 272943008348 Walker B; other site 272943008349 D-loop; other site 272943008350 H-loop/switch region; other site 272943008351 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272943008352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272943008353 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943008354 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 272943008355 homotrimer interaction site [polypeptide binding]; other site 272943008356 putative active site [active] 272943008357 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272943008358 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 272943008359 active site 272943008360 catalytic site [active] 272943008361 Protein of unknown function, DUF482; Region: DUF482; pfam04339 272943008362 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272943008363 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272943008364 putative C-terminal domain interface [polypeptide binding]; other site 272943008365 putative GSH binding site (G-site) [chemical binding]; other site 272943008366 putative dimer interface [polypeptide binding]; other site 272943008367 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 272943008368 dimer interface [polypeptide binding]; other site 272943008369 N-terminal domain interface [polypeptide binding]; other site 272943008370 putative substrate binding pocket (H-site) [chemical binding]; other site 272943008371 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 272943008372 aromatic arch; other site 272943008373 DCoH dimer interaction site [polypeptide binding]; other site 272943008374 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 272943008375 DCoH tetramer interaction site [polypeptide binding]; other site 272943008376 substrate binding site [chemical binding]; other site 272943008377 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 272943008378 catalytic triad [active] 272943008379 dimer interface [polypeptide binding]; other site 272943008380 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 272943008381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943008382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943008383 Reductase C-terminal; Region: Reductase_C; pfam14759 272943008384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943008385 S-adenosylmethionine binding site [chemical binding]; other site 272943008386 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272943008387 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272943008388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943008389 active site 272943008390 motif I; other site 272943008391 motif II; other site 272943008392 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 272943008393 putative heme binding pocket [chemical binding]; other site 272943008394 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272943008395 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272943008396 metal binding site [ion binding]; metal-binding site 272943008397 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 272943008398 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272943008399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943008400 ABC-ATPase subunit interface; other site 272943008401 dimer interface [polypeptide binding]; other site 272943008402 putative PBP binding regions; other site 272943008403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943008404 ABC-ATPase subunit interface; other site 272943008405 dimer interface [polypeptide binding]; other site 272943008406 putative PBP binding regions; other site 272943008407 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 272943008408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943008409 active site 272943008410 phosphorylation site [posttranslational modification] 272943008411 intermolecular recognition site; other site 272943008412 dimerization interface [polypeptide binding]; other site 272943008413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943008414 DNA binding residues [nucleotide binding] 272943008415 dimerization interface [polypeptide binding]; other site 272943008416 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272943008417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943008418 putative active site [active] 272943008419 heme pocket [chemical binding]; other site 272943008420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943008421 dimer interface [polypeptide binding]; other site 272943008422 phosphorylation site [posttranslational modification] 272943008423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943008424 ATP binding site [chemical binding]; other site 272943008425 Mg2+ binding site [ion binding]; other site 272943008426 G-X-G motif; other site 272943008427 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 272943008428 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272943008429 DctM-like transporters; Region: DctM; pfam06808 272943008430 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 272943008431 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272943008432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943008433 substrate binding site [chemical binding]; other site 272943008434 oxyanion hole (OAH) forming residues; other site 272943008435 trimer interface [polypeptide binding]; other site 272943008436 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 272943008437 classical (c) SDRs; Region: SDR_c; cd05233 272943008438 NAD(P) binding site [chemical binding]; other site 272943008439 active site 272943008440 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 272943008441 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272943008442 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272943008443 active site 272943008444 oxidoreductase; Provisional; Region: PRK06128 272943008445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943008446 NAD(P) binding site [chemical binding]; other site 272943008447 active site 272943008448 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 272943008449 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 272943008450 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 272943008451 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 272943008452 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272943008453 active site 272943008454 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 272943008455 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272943008456 putative MPT binding site; other site 272943008457 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272943008458 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943008459 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943008460 ligand binding site [chemical binding]; other site 272943008461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943008462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943008463 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272943008464 putative effector binding pocket; other site 272943008465 dimerization interface [polypeptide binding]; other site 272943008466 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272943008467 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272943008468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272943008469 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272943008470 putative active site [active] 272943008471 Ap4A binding site [chemical binding]; other site 272943008472 nudix motif; other site 272943008473 putative metal binding site [ion binding]; other site 272943008474 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272943008475 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272943008476 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272943008477 protein binding site [polypeptide binding]; other site 272943008478 Catalytic dyad [active] 272943008479 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272943008480 Peptidase family M23; Region: Peptidase_M23; pfam01551 272943008481 phosphoglyceromutase; Provisional; Region: PRK05434 272943008482 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272943008483 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272943008484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943008485 FeS/SAM binding site; other site 272943008486 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272943008487 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272943008488 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272943008489 trehalose synthase; Region: treS_nterm; TIGR02456 272943008490 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 272943008491 active site 272943008492 catalytic site [active] 272943008493 Protein of unknown function DUF72; Region: DUF72; pfam01904 272943008494 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272943008495 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943008496 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272943008497 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272943008498 Walker A/P-loop; other site 272943008499 ATP binding site [chemical binding]; other site 272943008500 Q-loop/lid; other site 272943008501 ABC transporter signature motif; other site 272943008502 Walker B; other site 272943008503 D-loop; other site 272943008504 H-loop/switch region; other site 272943008505 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943008506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943008507 dimer interface [polypeptide binding]; other site 272943008508 conserved gate region; other site 272943008509 putative PBP binding loops; other site 272943008510 ABC-ATPase subunit interface; other site 272943008511 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943008512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943008513 inhibitor-cofactor binding pocket; inhibition site 272943008514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943008515 catalytic residue [active] 272943008516 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 272943008517 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 272943008518 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 272943008519 putative active site [active] 272943008520 putative substrate binding site [chemical binding]; other site 272943008521 putative cosubstrate binding site; other site 272943008522 catalytic site [active] 272943008523 Transmembrane secretion effector; Region: MFS_3; pfam05977 272943008524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943008525 putative substrate translocation pore; other site 272943008526 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 272943008527 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 272943008528 active site 272943008529 DNA binding site [nucleotide binding] 272943008530 Int/Topo IB signature motif; other site 272943008531 catalytic residues [active] 272943008532 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 272943008533 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272943008534 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 272943008535 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 272943008536 active site 272943008537 homotetramer interface [polypeptide binding]; other site 272943008538 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 272943008539 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 272943008540 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 272943008541 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272943008542 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272943008543 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272943008544 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 272943008545 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272943008546 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272943008547 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272943008548 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272943008549 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 272943008550 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272943008551 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 272943008552 active site 272943008553 metal binding site [ion binding]; metal-binding site 272943008554 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272943008555 Protein of unknown function (DUF952); Region: DUF952; pfam06108 272943008556 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272943008557 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272943008558 quinone interaction residues [chemical binding]; other site 272943008559 active site 272943008560 catalytic residues [active] 272943008561 FMN binding site [chemical binding]; other site 272943008562 substrate binding site [chemical binding]; other site 272943008563 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943008564 AsnC family; Region: AsnC_trans_reg; pfam01037 272943008565 AAA domain; Region: AAA_30; pfam13604 272943008566 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272943008567 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 272943008568 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 272943008569 putative NAD(P) binding site [chemical binding]; other site 272943008570 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 272943008571 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272943008572 B12 binding site [chemical binding]; other site 272943008573 cobalt ligand [ion binding]; other site 272943008574 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 272943008575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943008576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943008577 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272943008578 MAPEG family; Region: MAPEG; cl09190 272943008579 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272943008580 E3 interaction surface; other site 272943008581 lipoyl attachment site [posttranslational modification]; other site 272943008582 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272943008583 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272943008584 E3 interaction surface; other site 272943008585 lipoyl attachment site [posttranslational modification]; other site 272943008586 Type III secretion protein (HpaP); Region: HpaP; cl17849 272943008587 e3 binding domain; Region: E3_binding; pfam02817 272943008588 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272943008589 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272943008590 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272943008591 TPP-binding site [chemical binding]; other site 272943008592 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272943008593 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272943008594 CoA binding domain; Region: CoA_binding; pfam02629 272943008595 CoA-ligase; Region: Ligase_CoA; pfam00549 272943008596 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272943008597 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272943008598 CoA-ligase; Region: Ligase_CoA; pfam00549 272943008599 malate dehydrogenase; Reviewed; Region: PRK06223 272943008600 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 272943008601 NAD(P) binding site [chemical binding]; other site 272943008602 dimer interface [polypeptide binding]; other site 272943008603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272943008604 substrate binding site [chemical binding]; other site 272943008605 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943008606 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 272943008607 NnrU protein; Region: NnrU; pfam07298 272943008608 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 272943008609 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 272943008610 putative active site [active] 272943008611 putative catalytic site [active] 272943008612 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 272943008613 putative active site [active] 272943008614 putative catalytic site [active] 272943008615 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 272943008616 Iron-sulfur protein interface; other site 272943008617 proximal quinone binding site [chemical binding]; other site 272943008618 SdhD (CybS) interface [polypeptide binding]; other site 272943008619 proximal heme binding site [chemical binding]; other site 272943008620 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 272943008621 putative SdhC subunit interface [polypeptide binding]; other site 272943008622 putative proximal heme binding site [chemical binding]; other site 272943008623 putative Iron-sulfur protein interface [polypeptide binding]; other site 272943008624 putative proximal quinone binding site; other site 272943008625 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 272943008626 L-aspartate oxidase; Provisional; Region: PRK06175 272943008627 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272943008628 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272943008629 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272943008630 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272943008631 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943008632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272943008633 DNA-binding site [nucleotide binding]; DNA binding site 272943008634 FCD domain; Region: FCD; pfam07729 272943008635 Protein of unknown function DUF45; Region: DUF45; pfam01863 272943008636 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 272943008637 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272943008638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272943008639 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272943008640 active site 272943008641 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943008642 EamA-like transporter family; Region: EamA; pfam00892 272943008643 EamA-like transporter family; Region: EamA; pfam00892 272943008644 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 272943008645 active site 272943008646 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943008647 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943008648 Walker A/P-loop; other site 272943008649 ATP binding site [chemical binding]; other site 272943008650 Q-loop/lid; other site 272943008651 ABC transporter signature motif; other site 272943008652 Walker B; other site 272943008653 D-loop; other site 272943008654 H-loop/switch region; other site 272943008655 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943008656 TM-ABC transporter signature motif; other site 272943008657 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272943008658 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272943008659 ligand binding site [chemical binding]; other site 272943008660 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272943008661 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943008662 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272943008663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272943008664 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 272943008665 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943008666 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 272943008667 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 272943008668 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 272943008669 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 272943008670 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943008671 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 272943008672 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 272943008673 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 272943008674 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 272943008675 Citrate transporter; Region: CitMHS; pfam03600 272943008676 transmembrane helices; other site 272943008677 Putative transcriptional regulator [Transcription]; Region: COG1678 272943008678 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 272943008679 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272943008680 Fe-S cluster binding site [ion binding]; other site 272943008681 active site 272943008682 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272943008683 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272943008684 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272943008685 dihydroorotase; Validated; Region: PRK09059 272943008686 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272943008687 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272943008688 active site 272943008689 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272943008690 glutamate--cysteine ligase; Region: PLN02611 272943008691 phytoene desaturase; Region: crtI_fam; TIGR02734 272943008692 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 272943008693 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 272943008694 putative active site [active] 272943008695 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943008696 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943008697 ligand binding site [chemical binding]; other site 272943008698 chromosome segregation protein; Provisional; Region: PRK02224 272943008699 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272943008700 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 272943008701 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272943008702 tetramerization interface [polypeptide binding]; other site 272943008703 NAD(P) binding site [chemical binding]; other site 272943008704 catalytic residues [active] 272943008705 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272943008706 Domain of unknown function DUF21; Region: DUF21; pfam01595 272943008707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272943008708 Transporter associated domain; Region: CorC_HlyC; smart01091 272943008709 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272943008710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943008711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272943008712 DNA binding residues [nucleotide binding] 272943008713 von Willebrand factor; Region: vWF_A; pfam12450 272943008714 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 272943008715 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 272943008716 metal ion-dependent adhesion site (MIDAS); other site 272943008717 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 272943008718 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272943008719 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272943008720 putative dimer interface [polypeptide binding]; other site 272943008721 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 272943008722 active site 272943008723 substrate binding sites [chemical binding]; other site 272943008724 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 272943008725 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272943008726 Cysteine-rich domain; Region: CCG; pfam02754 272943008727 Cysteine-rich domain; Region: CCG; pfam02754 272943008728 FAD binding domain; Region: FAD_binding_4; pfam01565 272943008729 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 272943008730 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 272943008731 FAD binding domain; Region: FAD_binding_4; pfam01565 272943008732 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272943008733 Protein of unknown function, DUF599; Region: DUF599; pfam04654 272943008734 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272943008735 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 272943008736 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 272943008737 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272943008738 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 272943008739 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272943008740 Protein of unknown function DUF58; Region: DUF58; pfam01882 272943008741 MoxR-like ATPases [General function prediction only]; Region: COG0714 272943008742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943008743 Walker A motif; other site 272943008744 ATP binding site [chemical binding]; other site 272943008745 Walker B motif; other site 272943008746 arginine finger; other site 272943008747 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 272943008748 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 272943008749 Zinc-finger domain; Region: zf-CHCC; pfam10276 272943008750 DNA polymerase I; Provisional; Region: PRK05755 272943008751 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272943008752 active site 272943008753 metal binding site 1 [ion binding]; metal-binding site 272943008754 putative 5' ssDNA interaction site; other site 272943008755 metal binding site 3; metal-binding site 272943008756 metal binding site 2 [ion binding]; metal-binding site 272943008757 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272943008758 putative DNA binding site [nucleotide binding]; other site 272943008759 putative metal binding site [ion binding]; other site 272943008760 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 272943008761 active site 272943008762 catalytic site [active] 272943008763 substrate binding site [chemical binding]; other site 272943008764 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272943008765 active site 272943008766 DNA binding site [nucleotide binding] 272943008767 catalytic site [active] 272943008768 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272943008769 nucleotide binding site/active site [active] 272943008770 HIT family signature motif; other site 272943008771 catalytic residue [active] 272943008772 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 272943008773 adenosine kinase; Provisional; Region: PTZ00247 272943008774 substrate binding site [chemical binding]; other site 272943008775 ATP binding site [chemical binding]; other site 272943008776 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272943008777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272943008778 minor groove reading motif; other site 272943008779 helix-hairpin-helix signature motif; other site 272943008780 substrate binding pocket [chemical binding]; other site 272943008781 active site 272943008782 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272943008783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943008784 Helix-turn-helix domain; Region: HTH_18; pfam12833 272943008785 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272943008786 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272943008787 DNA binding site [nucleotide binding] 272943008788 active site 272943008789 Glycine zipper; Region: Gly-zipper_Omp; pfam13488 272943008790 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943008791 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943008792 ligand binding site [chemical binding]; other site 272943008793 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 272943008794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943008795 DNA-binding site [nucleotide binding]; DNA binding site 272943008796 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272943008797 F0F1 ATP synthase subunit B; Provisional; Region: PRK13455 272943008798 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272943008799 F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454 272943008800 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 272943008801 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 272943008802 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272943008803 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 272943008804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943008805 dimerization interface [polypeptide binding]; other site 272943008806 putative DNA binding site [nucleotide binding]; other site 272943008807 putative Zn2+ binding site [ion binding]; other site 272943008808 malonyl-CoA synthase; Validated; Region: PRK07514 272943008809 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 272943008810 acyl-activating enzyme (AAE) consensus motif; other site 272943008811 active site 272943008812 AMP binding site [chemical binding]; other site 272943008813 CoA binding site [chemical binding]; other site 272943008814 ATPase MipZ; Region: MipZ; pfam09140 272943008815 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943008816 P-loop; other site 272943008817 Magnesium ion binding site [ion binding]; other site 272943008818 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 272943008819 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272943008820 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272943008821 RimM N-terminal domain; Region: RimM; pfam01782 272943008822 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 272943008823 PRC-barrel domain; Region: PRC; pfam05239 272943008824 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272943008825 chorismate mutase; Provisional; Region: PRK09239 272943008826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272943008827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272943008828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272943008829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272943008830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272943008831 signal recognition particle protein; Provisional; Region: PRK10867 272943008832 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272943008833 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272943008834 P loop; other site 272943008835 GTP binding site [chemical binding]; other site 272943008836 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272943008837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943008838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943008839 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272943008840 dimerization interface [polypeptide binding]; other site 272943008841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943008842 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 272943008843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943008844 ATP binding site [chemical binding]; other site 272943008845 Mg2+ binding site [ion binding]; other site 272943008846 G-X-G motif; other site 272943008847 mercuric reductase; Validated; Region: PRK06370 272943008848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943008849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943008850 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272943008851 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272943008852 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272943008853 Ribonuclease P; Region: Ribonuclease_P; pfam00825 272943008854 Haemolytic domain; Region: Haemolytic; pfam01809 272943008855 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 272943008856 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 272943008857 Ligand Binding Site [chemical binding]; other site 272943008858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272943008859 nucleotidyl binding site; other site 272943008860 metal binding site [ion binding]; metal-binding site 272943008861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943008862 membrane protein insertase; Provisional; Region: PRK01318 272943008863 YidC periplasmic domain; Region: YidC_periplas; pfam14849 272943008864 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272943008865 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 272943008866 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 272943008867 MOSC domain; Region: MOSC; pfam03473 272943008868 Predicted GTPase [General function prediction only]; Region: COG0218 272943008869 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272943008870 G1 box; other site 272943008871 GTP/Mg2+ binding site [chemical binding]; other site 272943008872 Switch I region; other site 272943008873 G2 box; other site 272943008874 G3 box; other site 272943008875 Switch II region; other site 272943008876 G4 box; other site 272943008877 G5 box; other site 272943008878 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943008879 classical (c) SDRs; Region: SDR_c; cd05233 272943008880 NAD(P) binding site [chemical binding]; other site 272943008881 active site 272943008882 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272943008883 feedback inhibition sensing region; other site 272943008884 homohexameric interface [polypeptide binding]; other site 272943008885 nucleotide binding site [chemical binding]; other site 272943008886 N-acetyl-L-glutamate binding site [chemical binding]; other site 272943008887 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 272943008888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272943008889 catalytic core [active] 272943008890 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272943008891 MoaE homodimer interface [polypeptide binding]; other site 272943008892 MoaD interaction [polypeptide binding]; other site 272943008893 active site residues [active] 272943008894 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272943008895 MoaE interaction surface [polypeptide binding]; other site 272943008896 MoeB interaction surface [polypeptide binding]; other site 272943008897 thiocarboxylated glycine; other site 272943008898 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272943008899 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272943008900 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272943008901 GIY-YIG motif/motif A; other site 272943008902 active site 272943008903 catalytic site [active] 272943008904 putative DNA binding site [nucleotide binding]; other site 272943008905 metal binding site [ion binding]; metal-binding site 272943008906 UvrB/uvrC motif; Region: UVR; pfam02151 272943008907 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272943008908 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272943008909 short chain dehydrogenase; Provisional; Region: PRK09134 272943008910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943008911 NAD(P) binding site [chemical binding]; other site 272943008912 active site 272943008913 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272943008914 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272943008915 tandem repeat interface [polypeptide binding]; other site 272943008916 oligomer interface [polypeptide binding]; other site 272943008917 active site residues [active] 272943008918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943008919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943008920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272943008921 dimerization interface [polypeptide binding]; other site 272943008922 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 272943008923 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 272943008924 putative dimer interface [polypeptide binding]; other site 272943008925 [2Fe-2S] cluster binding site [ion binding]; other site 272943008926 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 272943008927 putative dimer interface [polypeptide binding]; other site 272943008928 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 272943008929 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272943008930 SLBB domain; Region: SLBB; pfam10531 272943008931 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272943008932 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 272943008933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943008934 catalytic loop [active] 272943008935 iron binding site [ion binding]; other site 272943008936 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272943008937 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272943008938 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 272943008939 [4Fe-4S] binding site [ion binding]; other site 272943008940 molybdopterin cofactor binding site; other site 272943008941 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 272943008942 molybdopterin cofactor binding site; other site 272943008943 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 272943008944 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 272943008945 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 272943008946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943008947 putative ADP-binding pocket [chemical binding]; other site 272943008948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943008949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943008950 active site 272943008951 phosphorylation site [posttranslational modification] 272943008952 intermolecular recognition site; other site 272943008953 dimerization interface [polypeptide binding]; other site 272943008954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943008955 DNA binding site [nucleotide binding] 272943008956 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 272943008957 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 272943008958 active site 272943008959 ligand binding site [chemical binding]; other site 272943008960 homodimer interface [polypeptide binding]; other site 272943008961 NAD(P) binding site [chemical binding]; other site 272943008962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943008963 short chain dehydrogenase; Provisional; Region: PRK07024 272943008964 NAD(P) binding site [chemical binding]; other site 272943008965 active site 272943008966 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 272943008967 MFS/sugar transport protein; Region: MFS_2; pfam13347 272943008968 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 272943008969 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 272943008970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272943008971 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272943008972 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 272943008973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943008974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943008975 DNA binding residues [nucleotide binding] 272943008976 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 272943008977 Putative zinc-finger; Region: zf-HC2; pfam13490 272943008978 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 272943008979 RmuC family; Region: RmuC; pfam02646 272943008980 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272943008981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943008982 ATP binding site [chemical binding]; other site 272943008983 Mg2+ binding site [ion binding]; other site 272943008984 G-X-G motif; other site 272943008985 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272943008986 ATP binding site [chemical binding]; other site 272943008987 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272943008988 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272943008989 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272943008990 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272943008991 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272943008992 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272943008993 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 272943008994 lipoprotein signal peptidase; Provisional; Region: PRK14774 272943008995 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272943008996 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272943008997 purine monophosphate binding site [chemical binding]; other site 272943008998 dimer interface [polypeptide binding]; other site 272943008999 putative catalytic residues [active] 272943009000 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272943009001 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 272943009002 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 272943009003 putative RNA binding site [nucleotide binding]; other site 272943009004 16S rRNA methyltransferase B; Provisional; Region: PRK10901 272943009005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943009006 S-adenosylmethionine binding site [chemical binding]; other site 272943009007 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 272943009008 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272943009009 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272943009010 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272943009011 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272943009012 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl19845 272943009013 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 272943009014 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272943009015 RNA binding site [nucleotide binding]; other site 272943009016 active site 272943009017 cysteine synthase; Region: PLN02565 272943009018 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272943009019 dimer interface [polypeptide binding]; other site 272943009020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943009021 catalytic residue [active] 272943009022 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 272943009023 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272943009024 16S/18S rRNA binding site [nucleotide binding]; other site 272943009025 S13e-L30e interaction site [polypeptide binding]; other site 272943009026 25S rRNA binding site [nucleotide binding]; other site 272943009027 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272943009028 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272943009029 RNase E interface [polypeptide binding]; other site 272943009030 trimer interface [polypeptide binding]; other site 272943009031 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272943009032 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272943009033 RNase E interface [polypeptide binding]; other site 272943009034 trimer interface [polypeptide binding]; other site 272943009035 active site 272943009036 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272943009037 putative nucleic acid binding region [nucleotide binding]; other site 272943009038 G-X-X-G motif; other site 272943009039 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272943009040 RNA binding site [nucleotide binding]; other site 272943009041 domain interface; other site 272943009042 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943009043 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943009044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943009045 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 272943009046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943009047 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 272943009048 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 272943009049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943009050 Walker A/P-loop; other site 272943009051 ATP binding site [chemical binding]; other site 272943009052 Q-loop/lid; other site 272943009053 ABC transporter signature motif; other site 272943009054 Walker B; other site 272943009055 D-loop; other site 272943009056 H-loop/switch region; other site 272943009057 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272943009058 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 272943009059 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943009060 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 272943009061 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 272943009062 trimer interface [polypeptide binding]; other site 272943009063 active site 272943009064 substrate binding site [chemical binding]; other site 272943009065 CoA binding site [chemical binding]; other site 272943009066 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 272943009067 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 272943009068 putative active site [active] 272943009069 putative PHP Thumb interface [polypeptide binding]; other site 272943009070 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272943009071 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272943009072 lytic murein transglycosylase; Region: MltB_2; TIGR02283 272943009073 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272943009074 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943009075 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943009076 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943009077 ribonuclease R; Region: RNase_R; TIGR02063 272943009078 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 272943009079 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272943009080 RNA binding site [nucleotide binding]; other site 272943009081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272943009082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272943009083 Coenzyme A binding pocket [chemical binding]; other site 272943009084 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272943009085 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 272943009086 metal binding site [ion binding]; metal-binding site 272943009087 dimer interface [polypeptide binding]; other site 272943009088 Predicted membrane protein [Function unknown]; Region: COG2323 272943009089 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 272943009090 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 272943009091 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272943009092 trimer interface [polypeptide binding]; other site 272943009093 active site 272943009094 substrate binding site [chemical binding]; other site 272943009095 CoA binding site [chemical binding]; other site 272943009096 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 272943009097 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 272943009098 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272943009099 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272943009100 TPP-binding site; other site 272943009101 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272943009102 PYR/PP interface [polypeptide binding]; other site 272943009103 dimer interface [polypeptide binding]; other site 272943009104 TPP binding site [chemical binding]; other site 272943009105 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272943009106 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 272943009107 substrate binding pocket [chemical binding]; other site 272943009108 aspartate-rich region 2; other site 272943009109 substrate-Mg2+ binding site; other site 272943009110 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272943009111 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 272943009112 putative active site [active] 272943009113 Zn binding site [ion binding]; other site 272943009114 osmolarity response regulator; Provisional; Region: ompR; PRK09468 272943009115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009116 active site 272943009117 phosphorylation site [posttranslational modification] 272943009118 intermolecular recognition site; other site 272943009119 dimerization interface [polypeptide binding]; other site 272943009120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943009121 DNA binding site [nucleotide binding] 272943009122 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943009123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272943009124 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 272943009125 homodimer interface [polypeptide binding]; other site 272943009126 substrate-cofactor binding pocket; other site 272943009127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943009128 catalytic residue [active] 272943009129 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 272943009130 epoxyqueuosine reductase; Region: TIGR00276 272943009131 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272943009132 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272943009133 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272943009134 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272943009135 C-terminal domain interface [polypeptide binding]; other site 272943009136 GSH binding site (G-site) [chemical binding]; other site 272943009137 dimer interface [polypeptide binding]; other site 272943009138 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272943009139 N-terminal domain interface [polypeptide binding]; other site 272943009140 dimer interface [polypeptide binding]; other site 272943009141 substrate binding pocket (H-site) [chemical binding]; other site 272943009142 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272943009143 Transglycosylase; Region: Transgly; cl19357 272943009144 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272943009145 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272943009146 active site 272943009147 dimer interface [polypeptide binding]; other site 272943009148 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272943009149 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272943009150 active site 272943009151 FMN binding site [chemical binding]; other site 272943009152 substrate binding site [chemical binding]; other site 272943009153 3Fe-4S cluster binding site [ion binding]; other site 272943009154 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272943009155 domain interface; other site 272943009156 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272943009157 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 272943009158 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272943009159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943009160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943009161 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272943009162 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 272943009163 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272943009164 putative NAD(P) binding site [chemical binding]; other site 272943009165 active site 272943009166 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272943009167 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272943009168 catalytic site [active] 272943009169 putative active site [active] 272943009170 putative substrate binding site [chemical binding]; other site 272943009171 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 272943009172 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272943009173 putative active site [active] 272943009174 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272943009175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 272943009176 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 272943009177 OstA-like protein; Region: OstA; pfam03968 272943009178 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272943009179 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272943009180 Walker A/P-loop; other site 272943009181 ATP binding site [chemical binding]; other site 272943009182 Q-loop/lid; other site 272943009183 ABC transporter signature motif; other site 272943009184 Walker B; other site 272943009185 D-loop; other site 272943009186 H-loop/switch region; other site 272943009187 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272943009188 30S subunit binding site; other site 272943009189 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272943009190 active site 272943009191 phosphorylation site [posttranslational modification] 272943009192 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272943009193 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272943009194 active site 272943009195 tetramer interface; other site 272943009196 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 272943009197 Ligand binding site; other site 272943009198 oligomer interface; other site 272943009199 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272943009200 active site 272943009201 hypothetical protein; Provisional; Region: PRK14641 272943009202 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272943009203 putative oligomer interface [polypeptide binding]; other site 272943009204 putative RNA binding site [nucleotide binding]; other site 272943009205 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272943009206 NusA N-terminal domain; Region: NusA_N; pfam08529 272943009207 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272943009208 RNA binding site [nucleotide binding]; other site 272943009209 homodimer interface [polypeptide binding]; other site 272943009210 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272943009211 G-X-X-G motif; other site 272943009212 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272943009213 G-X-X-G motif; other site 272943009214 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272943009215 hypothetical protein; Provisional; Region: PRK09190 272943009216 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272943009217 putative RNA binding cleft [nucleotide binding]; other site 272943009218 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272943009219 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 272943009220 translation initiation factor IF-2; Region: IF-2; TIGR00487 272943009221 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272943009222 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272943009223 G1 box; other site 272943009224 putative GEF interaction site [polypeptide binding]; other site 272943009225 GTP/Mg2+ binding site [chemical binding]; other site 272943009226 Switch I region; other site 272943009227 G2 box; other site 272943009228 G3 box; other site 272943009229 Switch II region; other site 272943009230 G4 box; other site 272943009231 G5 box; other site 272943009232 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272943009233 Translation-initiation factor 2; Region: IF-2; pfam11987 272943009234 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272943009235 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272943009236 active site 272943009237 8-oxo-dGMP binding site [chemical binding]; other site 272943009238 nudix motif; other site 272943009239 metal binding site [ion binding]; metal-binding site 272943009240 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272943009241 heterotetramer interface [polypeptide binding]; other site 272943009242 active site pocket [active] 272943009243 cleavage site 272943009244 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 272943009245 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272943009246 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272943009247 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 272943009248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943009249 ATP binding site [chemical binding]; other site 272943009250 putative Mg++ binding site [ion binding]; other site 272943009251 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272943009252 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272943009253 SEC-C motif; Region: SEC-C; pfam02810 272943009254 PBP superfamily domain; Region: PBP_like_2; pfam12849 272943009255 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 272943009256 ligand binding site [chemical binding]; other site 272943009257 hypothetical protein; Reviewed; Region: PRK00024 272943009258 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272943009259 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272943009260 MPN+ (JAMM) motif; other site 272943009261 Zinc-binding site [ion binding]; other site 272943009262 chaperone protein DnaJ; Provisional; Region: PRK10767 272943009263 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272943009264 HSP70 interaction site [polypeptide binding]; other site 272943009265 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272943009266 substrate binding site [polypeptide binding]; other site 272943009267 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272943009268 Zn binding sites [ion binding]; other site 272943009269 dimer interface [polypeptide binding]; other site 272943009270 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272943009271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272943009272 nucleotide binding site [chemical binding]; other site 272943009273 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943009274 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272943009275 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 272943009276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943009277 S-adenosylmethionine binding site [chemical binding]; other site 272943009278 xylose isomerase; Provisional; Region: PRK05474 272943009279 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272943009280 N- and C-terminal domain interface [polypeptide binding]; other site 272943009281 D-xylulose kinase; Region: XylB; TIGR01312 272943009282 active site 272943009283 MgATP binding site [chemical binding]; other site 272943009284 catalytic site [active] 272943009285 metal binding site [ion binding]; metal-binding site 272943009286 xylulose binding site [chemical binding]; other site 272943009287 homodimer interface [polypeptide binding]; other site 272943009288 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272943009289 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943009290 Walker A/P-loop; other site 272943009291 ATP binding site [chemical binding]; other site 272943009292 Q-loop/lid; other site 272943009293 ABC transporter signature motif; other site 272943009294 Walker B; other site 272943009295 D-loop; other site 272943009296 H-loop/switch region; other site 272943009297 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943009298 TM-ABC transporter signature motif; other site 272943009299 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 272943009300 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 272943009301 putative ligand binding site [chemical binding]; other site 272943009302 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272943009303 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272943009304 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272943009305 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 272943009306 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272943009307 Surface antigen; Region: Bac_surface_Ag; pfam01103 272943009308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 272943009309 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272943009310 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272943009311 Family of unknown function (DUF490); Region: DUF490; pfam04357 272943009312 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272943009313 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 272943009314 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 272943009315 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 272943009316 CoA binding domain; Region: CoA_binding; cl17356 272943009317 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 272943009318 NAD(P) binding site [chemical binding]; other site 272943009319 homodimer interface [polypeptide binding]; other site 272943009320 substrate binding site [chemical binding]; other site 272943009321 active site 272943009322 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272943009323 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943009324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943009325 active site 272943009326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272943009327 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943009328 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272943009329 GSH binding site [chemical binding]; other site 272943009330 catalytic residues [active] 272943009331 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272943009332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943009333 active site 272943009334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272943009335 ferrochelatase; Reviewed; Region: hemH; PRK00035 272943009336 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272943009337 C-terminal domain interface [polypeptide binding]; other site 272943009338 active site 272943009339 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272943009340 active site 272943009341 N-terminal domain interface [polypeptide binding]; other site 272943009342 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943009343 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272943009344 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943009345 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272943009346 TRAM domain; Region: TRAM; cl01282 272943009347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943009348 S-adenosylmethionine binding site [chemical binding]; other site 272943009349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272943009350 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943009351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943009352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943009353 Walker A/P-loop; other site 272943009354 ATP binding site [chemical binding]; other site 272943009355 Q-loop/lid; other site 272943009356 ABC transporter signature motif; other site 272943009357 Walker B; other site 272943009358 D-loop; other site 272943009359 H-loop/switch region; other site 272943009360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943009361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943009362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943009363 Walker A/P-loop; other site 272943009364 ATP binding site [chemical binding]; other site 272943009365 Q-loop/lid; other site 272943009366 ABC transporter signature motif; other site 272943009367 Walker B; other site 272943009368 D-loop; other site 272943009369 H-loop/switch region; other site 272943009370 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272943009371 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272943009372 active site 272943009373 NTP binding site [chemical binding]; other site 272943009374 metal binding triad [ion binding]; metal-binding site 272943009375 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272943009376 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 272943009377 putative active site [active] 272943009378 putative CoA binding site [chemical binding]; other site 272943009379 nudix motif; other site 272943009380 metal binding site [ion binding]; metal-binding site 272943009381 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272943009382 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272943009383 dimerization interface [polypeptide binding]; other site 272943009384 domain crossover interface; other site 272943009385 redox-dependent activation switch; other site 272943009386 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272943009387 nudix motif; other site 272943009388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943009389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009390 active site 272943009391 phosphorylation site [posttranslational modification] 272943009392 intermolecular recognition site; other site 272943009393 dimerization interface [polypeptide binding]; other site 272943009394 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272943009395 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 272943009396 putative binding surface; other site 272943009397 active site 272943009398 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272943009399 ANP binding site [chemical binding]; other site 272943009400 Substrate Binding Site II [chemical binding]; other site 272943009401 Substrate Binding Site I [chemical binding]; other site 272943009402 Protein of unknown function (DUF533); Region: DUF533; pfam04391 272943009403 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 272943009404 putative metal binding site [ion binding]; other site 272943009405 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272943009406 homodimer interface [polypeptide binding]; other site 272943009407 substrate-cofactor binding pocket; other site 272943009408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943009409 catalytic residue [active] 272943009410 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272943009411 substrate binding site [chemical binding]; other site 272943009412 dimer interface [polypeptide binding]; other site 272943009413 ATP binding site [chemical binding]; other site 272943009414 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 272943009415 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272943009416 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272943009417 putative NAD(P) binding site [chemical binding]; other site 272943009418 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272943009419 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272943009420 MutS domain I; Region: MutS_I; pfam01624 272943009421 MutS domain II; Region: MutS_II; pfam05188 272943009422 MutS domain III; Region: MutS_III; pfam05192 272943009423 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272943009424 Walker A/P-loop; other site 272943009425 ATP binding site [chemical binding]; other site 272943009426 Q-loop/lid; other site 272943009427 ABC transporter signature motif; other site 272943009428 Walker B; other site 272943009429 D-loop; other site 272943009430 H-loop/switch region; other site 272943009431 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272943009432 dimer interface [polypeptide binding]; other site 272943009433 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272943009434 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272943009435 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272943009436 HrcA protein C terminal domain; Region: HrcA; pfam01628 272943009437 ribonuclease PH; Reviewed; Region: rph; PRK00173 272943009438 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272943009439 hexamer interface [polypeptide binding]; other site 272943009440 active site 272943009441 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272943009442 active site 272943009443 dimerization interface [polypeptide binding]; other site 272943009444 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 272943009445 homotrimer interaction site [polypeptide binding]; other site 272943009446 putative active site [active] 272943009447 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 272943009448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943009449 FeS/SAM binding site; other site 272943009450 HemN C-terminal domain; Region: HemN_C; pfam06969 272943009451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 272943009452 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272943009453 ParB-like nuclease domain; Region: ParBc; pfam02195 272943009454 KorB domain; Region: KorB; pfam08535 272943009455 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272943009456 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943009457 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943009458 P-loop; other site 272943009459 Magnesium ion binding site [ion binding]; other site 272943009460 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 272943009461 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272943009462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943009463 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272943009464 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272943009465 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272943009466 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272943009467 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272943009468 G1 box; other site 272943009469 GTP/Mg2+ binding site [chemical binding]; other site 272943009470 Switch I region; other site 272943009471 G2 box; other site 272943009472 Switch II region; other site 272943009473 G3 box; other site 272943009474 G4 box; other site 272943009475 G5 box; other site 272943009476 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272943009477 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272943009478 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 272943009479 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272943009480 RNA binding site [nucleotide binding]; other site 272943009481 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272943009482 multimer interface [polypeptide binding]; other site 272943009483 Walker A motif; other site 272943009484 ATP binding site [chemical binding]; other site 272943009485 Walker B motif; other site 272943009486 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 272943009487 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272943009488 active site 272943009489 dimer interface [polypeptide binding]; other site 272943009490 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272943009491 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272943009492 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272943009493 shikimate binding site; other site 272943009494 NAD(P) binding site [chemical binding]; other site 272943009495 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272943009496 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272943009497 CoA-binding site [chemical binding]; other site 272943009498 ATP-binding [chemical binding]; other site 272943009499 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272943009500 active site 272943009501 catalytic site [active] 272943009502 substrate binding site [chemical binding]; other site 272943009503 Preprotein translocase subunit SecB; Region: SecB; pfam02556 272943009504 SecA binding site; other site 272943009505 Preprotein binding site; other site 272943009506 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 272943009507 Tim44-like domain; Region: Tim44; pfam04280 272943009508 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 272943009509 MltA specific insert domain; Region: MltA; smart00925 272943009510 3D domain; Region: 3D; pfam06725 272943009511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 272943009512 Smr domain; Region: Smr; pfam01713 272943009513 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 272943009514 putative metal binding site [ion binding]; other site 272943009515 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272943009516 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272943009517 DNA binding site [nucleotide binding] 272943009518 domain linker motif; other site 272943009519 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 272943009520 dimerization interface [polypeptide binding]; other site 272943009521 ligand binding site [chemical binding]; other site 272943009522 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272943009523 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272943009524 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 272943009525 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272943009526 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272943009527 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272943009528 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272943009529 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943009530 Walker A/P-loop; other site 272943009531 ATP binding site [chemical binding]; other site 272943009532 Q-loop/lid; other site 272943009533 ABC transporter signature motif; other site 272943009534 Walker B; other site 272943009535 D-loop; other site 272943009536 H-loop/switch region; other site 272943009537 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272943009538 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943009539 TM-ABC transporter signature motif; other site 272943009540 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272943009541 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 272943009542 putative ligand binding site [chemical binding]; other site 272943009543 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 272943009544 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272943009545 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272943009546 FMN binding site [chemical binding]; other site 272943009547 Acetokinase family; Region: Acetate_kinase; cl17229 272943009548 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 272943009549 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 272943009550 dimer interaction site [polypeptide binding]; other site 272943009551 substrate-binding tunnel; other site 272943009552 active site 272943009553 catalytic site [active] 272943009554 substrate binding site [chemical binding]; other site 272943009555 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272943009556 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272943009557 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272943009558 NAD binding site [chemical binding]; other site 272943009559 homotetramer interface [polypeptide binding]; other site 272943009560 homodimer interface [polypeptide binding]; other site 272943009561 substrate binding site [chemical binding]; other site 272943009562 active site 272943009563 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 272943009564 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272943009565 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272943009566 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943009567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943009568 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272943009569 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 272943009570 Sensors of blue-light using FAD; Region: BLUF; pfam04940 272943009571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009572 active site 272943009573 phosphorylation site [posttranslational modification] 272943009574 intermolecular recognition site; other site 272943009575 dimerization interface [polypeptide binding]; other site 272943009576 Microtubule associated protein (MAP65/ASE1 family); Region: MAP65_ASE1; pfam03999 272943009577 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272943009578 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272943009579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272943009580 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272943009581 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272943009582 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 272943009583 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272943009584 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272943009585 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272943009586 Ligand Binding Site [chemical binding]; other site 272943009587 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272943009588 GAF domain; Region: GAF_3; pfam13492 272943009589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943009590 dimer interface [polypeptide binding]; other site 272943009591 phosphorylation site [posttranslational modification] 272943009592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943009593 ATP binding site [chemical binding]; other site 272943009594 Mg2+ binding site [ion binding]; other site 272943009595 G-X-G motif; other site 272943009596 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 272943009597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009598 active site 272943009599 phosphorylation site [posttranslational modification] 272943009600 intermolecular recognition site; other site 272943009601 dimerization interface [polypeptide binding]; other site 272943009602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943009603 DNA binding site [nucleotide binding] 272943009604 CsbD-like; Region: CsbD; cl17424 272943009605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943009606 dimerization interface [polypeptide binding]; other site 272943009607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943009608 Histidine kinase; Region: HisKA_2; pfam07568 272943009609 RNA polymerase sigma factor; Provisional; Region: PRK12546 272943009610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943009611 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272943009612 DNA binding residues [nucleotide binding] 272943009613 two-component response regulator; Provisional; Region: PRK09191 272943009614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272943009615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009616 active site 272943009617 phosphorylation site [posttranslational modification] 272943009618 intermolecular recognition site; other site 272943009619 dimerization interface [polypeptide binding]; other site 272943009620 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 272943009621 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943009622 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943009623 ligand binding site [chemical binding]; other site 272943009624 flexible hinge region; other site 272943009625 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272943009626 putative switch regulator; other site 272943009627 non-specific DNA interactions [nucleotide binding]; other site 272943009628 DNA binding site [nucleotide binding] 272943009629 sequence specific DNA binding site [nucleotide binding]; other site 272943009630 putative cAMP binding site [chemical binding]; other site 272943009631 dimerization interface [polypeptide binding]; other site 272943009632 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 272943009633 putative active cleft [active] 272943009634 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 272943009635 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272943009636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943009637 motif II; other site 272943009638 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272943009639 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272943009640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943009641 motif II; other site 272943009642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943009643 Walker A motif; other site 272943009644 ATP binding site [chemical binding]; other site 272943009645 Walker B motif; other site 272943009646 arginine finger; other site 272943009647 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 272943009648 multimerization interface [polypeptide binding]; other site 272943009649 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 272943009650 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 272943009651 homodimer interface [polypeptide binding]; other site 272943009652 active site 272943009653 heterodimer interface [polypeptide binding]; other site 272943009654 catalytic residue [active] 272943009655 metal binding site [ion binding]; metal-binding site 272943009656 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272943009657 intersubunit interface [polypeptide binding]; other site 272943009658 active site 272943009659 zinc binding site [ion binding]; other site 272943009660 Na+ binding site [ion binding]; other site 272943009661 phosphoribulokinase; Provisional; Region: PRK15453 272943009662 active site 272943009663 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 272943009664 AMP binding site [chemical binding]; other site 272943009665 metal binding site [ion binding]; metal-binding site 272943009666 active site 272943009667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943009668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943009669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943009670 dimerization interface [polypeptide binding]; other site 272943009671 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272943009672 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272943009673 Walker A/P-loop; other site 272943009674 ATP binding site [chemical binding]; other site 272943009675 Q-loop/lid; other site 272943009676 ABC transporter signature motif; other site 272943009677 Walker B; other site 272943009678 D-loop; other site 272943009679 H-loop/switch region; other site 272943009680 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943009681 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272943009682 Walker A/P-loop; other site 272943009683 ATP binding site [chemical binding]; other site 272943009684 Q-loop/lid; other site 272943009685 ABC transporter signature motif; other site 272943009686 Walker B; other site 272943009687 D-loop; other site 272943009688 H-loop/switch region; other site 272943009689 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272943009690 TM-ABC transporter signature motif; other site 272943009691 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272943009692 TM-ABC transporter signature motif; other site 272943009693 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 272943009694 ligand binding site [chemical binding]; other site 272943009695 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 272943009696 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 272943009697 tetrameric interface [polypeptide binding]; other site 272943009698 NAD binding site [chemical binding]; other site 272943009699 catalytic residues [active] 272943009700 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272943009701 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272943009702 TPP-binding site [chemical binding]; other site 272943009703 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272943009704 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272943009705 alpha subunit interface [polypeptide binding]; other site 272943009706 TPP binding site [chemical binding]; other site 272943009707 heterodimer interface [polypeptide binding]; other site 272943009708 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272943009709 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 272943009710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943009711 FAD binding site [chemical binding]; other site 272943009712 substrate binding pocket [chemical binding]; other site 272943009713 catalytic base [active] 272943009714 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272943009715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943009716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943009717 dimerization interface [polypeptide binding]; other site 272943009718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272943009719 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272943009720 active site 272943009721 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 272943009722 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272943009723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272943009724 TPR motif; other site 272943009725 binding surface 272943009726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272943009727 TPR motif; other site 272943009728 PAP2 superfamily; Region: PAP2; pfam01569 272943009729 active site 272943009730 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272943009731 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272943009732 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 272943009733 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 272943009734 ligand binding site [chemical binding]; other site 272943009735 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272943009736 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 272943009737 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272943009738 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943009739 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 272943009740 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943009741 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 272943009742 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272943009743 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 272943009744 PAS domain; Region: PAS_9; pfam13426 272943009745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943009746 putative active site [active] 272943009747 heme pocket [chemical binding]; other site 272943009748 PAS domain; Region: PAS_8; pfam13188 272943009749 PAS fold; Region: PAS_4; pfam08448 272943009750 histidine kinase; Provisional; Region: PRK13557 272943009751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943009752 putative active site [active] 272943009753 heme pocket [chemical binding]; other site 272943009754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943009755 dimer interface [polypeptide binding]; other site 272943009756 phosphorylation site [posttranslational modification] 272943009757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943009758 ATP binding site [chemical binding]; other site 272943009759 Mg2+ binding site [ion binding]; other site 272943009760 G-X-G motif; other site 272943009761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009762 active site 272943009763 phosphorylation site [posttranslational modification] 272943009764 intermolecular recognition site; other site 272943009765 dimerization interface [polypeptide binding]; other site 272943009766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009767 active site 272943009768 phosphorylation site [posttranslational modification] 272943009769 intermolecular recognition site; other site 272943009770 dimerization interface [polypeptide binding]; other site 272943009771 HTH DNA binding domain; Region: HTH_13; pfam11972 272943009772 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272943009773 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272943009774 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 272943009775 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272943009776 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 272943009777 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272943009778 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 272943009779 Uncharacterized conserved protein [Function unknown]; Region: COG3334 272943009780 flagellar motor protein MotA; Validated; Region: PRK09110 272943009781 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272943009782 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272943009783 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 272943009784 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 272943009785 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 272943009786 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 272943009787 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 272943009788 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272943009789 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 272943009790 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 272943009791 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272943009792 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272943009793 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943009794 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690 272943009795 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272943009796 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 272943009797 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 272943009798 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 272943009799 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632 272943009800 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272943009801 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272943009802 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627 272943009803 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272943009804 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 272943009805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943009806 Walker A motif; other site 272943009807 ATP binding site [chemical binding]; other site 272943009808 Walker B motif; other site 272943009809 Rod binding protein; Region: Rod-binding; pfam10135 272943009810 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272943009811 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 272943009812 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272943009813 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 272943009814 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272943009815 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272943009816 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272943009817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943009818 S-adenosylmethionine binding site [chemical binding]; other site 272943009819 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272943009820 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272943009821 DNA binding site [nucleotide binding] 272943009822 catalytic residue [active] 272943009823 H2TH interface [polypeptide binding]; other site 272943009824 putative catalytic residues [active] 272943009825 turnover-facilitating residue; other site 272943009826 intercalation triad [nucleotide binding]; other site 272943009827 8OG recognition residue [nucleotide binding]; other site 272943009828 putative reading head residues; other site 272943009829 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272943009830 enoyl-CoA hydratase; Provisional; Region: PRK05862 272943009831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943009832 substrate binding site [chemical binding]; other site 272943009833 oxyanion hole (OAH) forming residues; other site 272943009834 trimer interface [polypeptide binding]; other site 272943009835 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272943009836 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272943009837 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272943009838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943009839 Walker A motif; other site 272943009840 ATP binding site [chemical binding]; other site 272943009841 Walker B motif; other site 272943009842 arginine finger; other site 272943009843 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272943009844 DnaA box-binding interface [nucleotide binding]; other site 272943009845 DNA polymerase III subunit beta; Validated; Region: PRK05643 272943009846 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272943009847 putative DNA binding surface [nucleotide binding]; other site 272943009848 dimer interface [polypeptide binding]; other site 272943009849 beta-clamp/clamp loader binding surface; other site 272943009850 beta-clamp/translesion DNA polymerase binding surface; other site 272943009851 recombination protein F; Reviewed; Region: recF; PRK00064 272943009852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943009853 Walker A/P-loop; other site 272943009854 ATP binding site [chemical binding]; other site 272943009855 Q-loop/lid; other site 272943009856 ABC transporter signature motif; other site 272943009857 Walker B; other site 272943009858 D-loop; other site 272943009859 H-loop/switch region; other site 272943009860 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 272943009861 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272943009862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943009863 ATP binding site [chemical binding]; other site 272943009864 Mg2+ binding site [ion binding]; other site 272943009865 G-X-G motif; other site 272943009866 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272943009867 anchoring element; other site 272943009868 dimer interface [polypeptide binding]; other site 272943009869 ATP binding site [chemical binding]; other site 272943009870 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272943009871 active site 272943009872 putative metal-binding site [ion binding]; other site 272943009873 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272943009874 Predicted membrane protein [Function unknown]; Region: COG4325 272943009875 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 272943009876 Predicted ATPase [General function prediction only]; Region: COG1485 272943009877 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272943009878 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272943009879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272943009880 motif II; other site 272943009881 IMG reference gene:2512956397; serC leader; RSP_7708 272943009882 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 272943009883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272943009884 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272943009885 catalytic residue [active] 272943009886 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 272943009887 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 272943009888 ligand binding site [chemical binding]; other site 272943009889 NAD binding site [chemical binding]; other site 272943009890 dimerization interface [polypeptide binding]; other site 272943009891 catalytic site [active] 272943009892 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 272943009893 putative L-serine binding site [chemical binding]; other site 272943009894 putative protein phosphatase; Region: PHA02239 272943009895 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272943009896 active site 272943009897 metal binding site [ion binding]; metal-binding site 272943009898 beta-ketothiolase; Provisional; Region: PRK09051 272943009899 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272943009900 dimer interface [polypeptide binding]; other site 272943009901 active site 272943009902 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 272943009903 Transglycosylase; Region: Transgly; pfam00912 272943009904 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272943009905 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 272943009906 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 272943009907 putative binding site; other site 272943009908 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 272943009909 MG2 domain; Region: A2M_N; pfam01835 272943009910 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 272943009911 Alpha-2-macroglobulin family; Region: A2M; pfam00207 272943009912 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 272943009913 surface patch; other site 272943009914 thioester region; other site 272943009915 specificity defining residues; other site 272943009916 PAS fold; Region: PAS_7; pfam12860 272943009917 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272943009918 PAS domain; Region: PAS_8; pfam13188 272943009919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943009920 dimer interface [polypeptide binding]; other site 272943009921 phosphorylation site [posttranslational modification] 272943009922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943009923 ATP binding site [chemical binding]; other site 272943009924 Mg2+ binding site [ion binding]; other site 272943009925 G-X-G motif; other site 272943009926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009927 active site 272943009928 phosphorylation site [posttranslational modification] 272943009929 intermolecular recognition site; other site 272943009930 dimerization interface [polypeptide binding]; other site 272943009931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943009932 active site 272943009933 phosphorylation site [posttranslational modification] 272943009934 intermolecular recognition site; other site 272943009935 dimerization interface [polypeptide binding]; other site 272943009936 Protein of unknown function (DUF328); Region: DUF328; pfam03883 272943009937 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 272943009938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272943009939 ATP binding site [chemical binding]; other site 272943009940 putative Mg++ binding site [ion binding]; other site 272943009941 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272943009942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272943009943 active site residue [active] 272943009944 nucleotide binding region [chemical binding]; other site 272943009945 ATP-binding site [chemical binding]; other site 272943009946 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272943009947 HRDC domain; Region: HRDC; pfam00570 272943009948 HRDC domain; Region: HRDC; pfam00570 272943009949 YGGT family; Region: YGGT; pfam02325 272943009950 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272943009951 active site 272943009952 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272943009953 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 272943009954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 272943009955 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 272943009956 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 272943009957 hypothetical protein; Provisional; Region: PRK09256 272943009958 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 272943009959 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 272943009960 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 272943009961 catalytic triad [active] 272943009962 metal binding site [ion binding]; metal-binding site 272943009963 conserved cis-peptide bond; other site 272943009964 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 272943009965 classical (c) SDRs; Region: SDR_c; cd05233 272943009966 NAD(P) binding site [chemical binding]; other site 272943009967 active site 272943009968 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 272943009969 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 272943009970 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272943009971 active site 272943009972 catalytic site [active] 272943009973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943009974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943009975 putative substrate translocation pore; other site 272943009976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943009977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943009978 putative substrate translocation pore; other site 272943009979 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943009980 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272943009981 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 272943009982 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272943009983 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272943009984 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272943009985 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 272943009986 active site clefts [active] 272943009987 zinc binding site [ion binding]; other site 272943009988 dimer interface [polypeptide binding]; other site 272943009989 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272943009990 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272943009991 interface (dimer of trimers) [polypeptide binding]; other site 272943009992 Substrate-binding/catalytic site; other site 272943009993 Zn-binding sites [ion binding]; other site 272943009994 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272943009995 NlpC/P60 family; Region: NLPC_P60; pfam00877 272943009996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 272943009997 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 272943009998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943009999 FeS/SAM binding site; other site 272943010000 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 272943010001 L-asparaginase II; Region: Asparaginase_II; pfam06089 272943010002 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 272943010003 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272943010004 putative NAD(P) binding site [chemical binding]; other site 272943010005 AMP nucleosidase; Provisional; Region: PRK08292 272943010006 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 272943010007 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 272943010008 histone-like DNA-binding protein HU; Region: HU; cd13831 272943010009 dimer interface [polypeptide binding]; other site 272943010010 DNA binding site [nucleotide binding] 272943010011 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272943010012 EamA-like transporter family; Region: EamA; pfam00892 272943010013 EamA-like transporter family; Region: EamA; pfam00892 272943010014 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272943010015 Tetramer interface [polypeptide binding]; other site 272943010016 active site 272943010017 FMN-binding site [chemical binding]; other site 272943010018 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 272943010019 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 272943010020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010021 dimer interface [polypeptide binding]; other site 272943010022 conserved gate region; other site 272943010023 putative PBP binding loops; other site 272943010024 ABC-ATPase subunit interface; other site 272943010025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272943010026 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 272943010027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943010028 Walker A/P-loop; other site 272943010029 ATP binding site [chemical binding]; other site 272943010030 Q-loop/lid; other site 272943010031 ABC transporter signature motif; other site 272943010032 Walker B; other site 272943010033 D-loop; other site 272943010034 H-loop/switch region; other site 272943010035 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 272943010036 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 272943010037 cytochrome b; Provisional; Region: CYTB; MTH00191 272943010038 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272943010039 intrachain domain interface; other site 272943010040 interchain domain interface [polypeptide binding]; other site 272943010041 heme bH binding site [chemical binding]; other site 272943010042 Qi binding site; other site 272943010043 heme bL binding site [chemical binding]; other site 272943010044 Qo binding site; other site 272943010045 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 272943010046 interchain domain interface [polypeptide binding]; other site 272943010047 intrachain domain interface; other site 272943010048 Qi binding site; other site 272943010049 Qo binding site; other site 272943010050 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 272943010051 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 272943010052 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 272943010053 [2Fe-2S] cluster binding site [ion binding]; other site 272943010054 putative glutathione S-transferase; Provisional; Region: PRK10357 272943010055 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 272943010056 putative C-terminal domain interface [polypeptide binding]; other site 272943010057 putative GSH binding site (G-site) [chemical binding]; other site 272943010058 putative dimer interface [polypeptide binding]; other site 272943010059 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 272943010060 dimer interface [polypeptide binding]; other site 272943010061 N-terminal domain interface [polypeptide binding]; other site 272943010062 putative substrate binding pocket (H-site) [chemical binding]; other site 272943010063 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 272943010064 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 272943010065 DNA polymerase IV; Provisional; Region: PRK02794 272943010066 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272943010067 active site 272943010068 DNA binding site [nucleotide binding] 272943010069 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272943010070 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 272943010071 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 272943010072 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272943010073 active site 272943010074 dimer interface [polypeptide binding]; other site 272943010075 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272943010076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272943010077 nucleotide binding site [chemical binding]; other site 272943010078 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272943010079 Clp amino terminal domain; Region: Clp_N; pfam02861 272943010080 Clp amino terminal domain; Region: Clp_N; pfam02861 272943010081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943010082 Walker A motif; other site 272943010083 ATP binding site [chemical binding]; other site 272943010084 Walker B motif; other site 272943010085 arginine finger; other site 272943010086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943010087 Walker A motif; other site 272943010088 ATP binding site [chemical binding]; other site 272943010089 Walker B motif; other site 272943010090 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272943010091 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 272943010092 Fasciclin domain; Region: Fasciclin; pfam02469 272943010093 TMAO/DMSO reductase; Reviewed; Region: PRK05363 272943010094 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272943010095 Moco binding site; other site 272943010096 metal coordination site [ion binding]; other site 272943010097 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 272943010098 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 272943010099 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272943010100 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272943010101 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272943010102 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272943010103 catalytic residues [active] 272943010104 catalytic nucleophile [active] 272943010105 Recombinase; Region: Recombinase; pfam07508 272943010106 ParB-like nuclease domain; Region: ParB; smart00470 272943010107 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272943010108 RepB plasmid partitioning protein; Region: RepB; pfam07506 272943010109 ParB-like nuclease domain; Region: ParB; smart00470 272943010110 RepB plasmid partitioning protein; Region: RepB; pfam07506 272943010111 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 272943010112 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272943010113 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272943010114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272943010115 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272943010116 GTPase CgtA; Reviewed; Region: obgE; PRK12299 272943010117 GTP1/OBG; Region: GTP1_OBG; pfam01018 272943010118 Obg GTPase; Region: Obg; cd01898 272943010119 G1 box; other site 272943010120 GTP/Mg2+ binding site [chemical binding]; other site 272943010121 Switch I region; other site 272943010122 G2 box; other site 272943010123 G3 box; other site 272943010124 Switch II region; other site 272943010125 G4 box; other site 272943010126 G5 box; other site 272943010127 gamma-glutamyl kinase; Provisional; Region: PRK05429 272943010128 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272943010129 nucleotide binding site [chemical binding]; other site 272943010130 homotetrameric interface [polypeptide binding]; other site 272943010131 putative phosphate binding site [ion binding]; other site 272943010132 putative allosteric binding site; other site 272943010133 PUA domain; Region: PUA; pfam01472 272943010134 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272943010135 putative catalytic cysteine [active] 272943010136 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 272943010137 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 272943010138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 272943010139 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272943010140 putative acyl-acceptor binding pocket; other site 272943010141 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272943010142 thiamine phosphate binding site [chemical binding]; other site 272943010143 active site 272943010144 pyrophosphate binding site [ion binding]; other site 272943010145 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 272943010146 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 272943010147 EthD domain; Region: EthD; cl17553 272943010148 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 272943010149 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272943010150 active site 272943010151 Zn binding site [ion binding]; other site 272943010152 enoyl-CoA hydratase; Validated; Region: PRK08139 272943010153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943010154 substrate binding site [chemical binding]; other site 272943010155 oxyanion hole (OAH) forming residues; other site 272943010156 trimer interface [polypeptide binding]; other site 272943010157 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272943010158 CoenzymeA binding site [chemical binding]; other site 272943010159 subunit interaction site [polypeptide binding]; other site 272943010160 PHB binding site; other site 272943010161 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 272943010162 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 272943010163 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 272943010164 active site 272943010165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272943010166 metal ion-dependent adhesion site (MIDAS); other site 272943010167 Helix-turn-helix domain; Region: HTH_28; pfam13518 272943010168 Winged helix-turn helix; Region: HTH_29; pfam13551 272943010169 Homeodomain-like domain; Region: HTH_32; pfam13565 272943010170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272943010171 Transposase; Region: HTH_Tnp_1; pfam01527 272943010172 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 272943010173 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 272943010174 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272943010175 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 272943010176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943010177 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 272943010178 Flavin binding site [chemical binding]; other site 272943010179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943010180 SnoaL-like domain; Region: SnoaL_4; pfam13577 272943010181 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 272943010182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272943010183 active site 272943010184 metal binding site [ion binding]; metal-binding site 272943010185 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 272943010186 active site 272943010187 metal binding site [ion binding]; metal-binding site 272943010188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943010189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943010190 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 272943010191 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 272943010192 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272943010193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272943010194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943010195 DNA-binding site [nucleotide binding]; DNA binding site 272943010196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943010197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943010198 homodimer interface [polypeptide binding]; other site 272943010199 catalytic residue [active] 272943010200 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 272943010201 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272943010202 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 272943010203 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 272943010204 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272943010205 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272943010206 substrate-cofactor binding pocket; other site 272943010207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943010208 catalytic residue [active] 272943010209 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943010210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943010211 DNA-binding site [nucleotide binding]; DNA binding site 272943010212 FCD domain; Region: FCD; pfam07729 272943010213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943010214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010215 dimer interface [polypeptide binding]; other site 272943010216 conserved gate region; other site 272943010217 putative PBP binding loops; other site 272943010218 ABC-ATPase subunit interface; other site 272943010219 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943010220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272943010221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010222 dimer interface [polypeptide binding]; other site 272943010223 conserved gate region; other site 272943010224 putative PBP binding loops; other site 272943010225 ABC-ATPase subunit interface; other site 272943010226 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272943010227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010228 Walker A/P-loop; other site 272943010229 ATP binding site [chemical binding]; other site 272943010230 Q-loop/lid; other site 272943010231 ABC transporter signature motif; other site 272943010232 Walker B; other site 272943010233 D-loop; other site 272943010234 H-loop/switch region; other site 272943010235 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943010236 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272943010237 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010238 Walker A/P-loop; other site 272943010239 ATP binding site [chemical binding]; other site 272943010240 Q-loop/lid; other site 272943010241 ABC transporter signature motif; other site 272943010242 Walker B; other site 272943010243 D-loop; other site 272943010244 H-loop/switch region; other site 272943010245 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943010246 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943010247 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272943010248 H+ Antiporter protein; Region: 2A0121; TIGR00900 272943010249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943010250 putative substrate translocation pore; other site 272943010251 Predicted acyl esterases [General function prediction only]; Region: COG2936 272943010252 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943010253 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 272943010254 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943010255 classical (c) SDRs; Region: SDR_c; cd05233 272943010256 NAD(P) binding site [chemical binding]; other site 272943010257 active site 272943010258 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943010259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010260 dimer interface [polypeptide binding]; other site 272943010261 conserved gate region; other site 272943010262 putative PBP binding loops; other site 272943010263 ABC-ATPase subunit interface; other site 272943010264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010265 dimer interface [polypeptide binding]; other site 272943010266 conserved gate region; other site 272943010267 putative PBP binding loops; other site 272943010268 ABC-ATPase subunit interface; other site 272943010269 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943010270 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943010271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943010272 Walker A/P-loop; other site 272943010273 ATP binding site [chemical binding]; other site 272943010274 Q-loop/lid; other site 272943010275 ABC transporter signature motif; other site 272943010276 Walker B; other site 272943010277 D-loop; other site 272943010278 H-loop/switch region; other site 272943010279 TOBE domain; Region: TOBE_2; pfam08402 272943010280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943010281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943010282 DNA binding residues [nucleotide binding] 272943010283 dimerization interface [polypeptide binding]; other site 272943010284 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272943010285 PAS domain; Region: PAS_8; pfam13188 272943010286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943010287 dimer interface [polypeptide binding]; other site 272943010288 phosphorylation site [posttranslational modification] 272943010289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943010290 ATP binding site [chemical binding]; other site 272943010291 Mg2+ binding site [ion binding]; other site 272943010292 G-X-G motif; other site 272943010293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943010294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943010295 active site 272943010296 phosphorylation site [posttranslational modification] 272943010297 intermolecular recognition site; other site 272943010298 dimerization interface [polypeptide binding]; other site 272943010299 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272943010300 putative binding surface; other site 272943010301 active site 272943010302 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 272943010303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943010304 active site 272943010305 phosphorylation site [posttranslational modification] 272943010306 intermolecular recognition site; other site 272943010307 dimerization interface [polypeptide binding]; other site 272943010308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943010309 DNA binding site [nucleotide binding] 272943010310 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 272943010311 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 272943010312 cytochrome c-550; Provisional; Region: psbV; cl17239 272943010313 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 272943010314 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 272943010315 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 272943010316 molybdopterin cofactor binding site [chemical binding]; other site 272943010317 substrate binding site [chemical binding]; other site 272943010318 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 272943010319 molybdopterin cofactor binding site; other site 272943010320 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272943010321 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272943010322 dimer interface [polypeptide binding]; other site 272943010323 putative functional site; other site 272943010324 putative MPT binding site; other site 272943010325 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 272943010326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943010327 FeS/SAM binding site; other site 272943010328 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272943010329 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 272943010330 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 272943010331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943010332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943010333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943010334 dimerization interface [polypeptide binding]; other site 272943010335 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272943010336 Zn binding site [ion binding]; other site 272943010337 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272943010338 Zn binding site [ion binding]; other site 272943010339 putative hydrolase; Provisional; Region: PRK11460 272943010340 Predicted esterase [General function prediction only]; Region: COG0400 272943010341 Bacterial SH3 domain; Region: SH3_3; pfam08239 272943010342 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943010343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272943010344 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 272943010345 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272943010346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943010347 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 272943010348 Walker A/P-loop; other site 272943010349 ATP binding site [chemical binding]; other site 272943010350 Q-loop/lid; other site 272943010351 ABC transporter signature motif; other site 272943010352 Walker B; other site 272943010353 D-loop; other site 272943010354 H-loop/switch region; other site 272943010355 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272943010356 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943010357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010358 dimer interface [polypeptide binding]; other site 272943010359 conserved gate region; other site 272943010360 putative PBP binding loops; other site 272943010361 ABC-ATPase subunit interface; other site 272943010362 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 272943010363 serine O-acetyltransferase; Region: cysE; TIGR01172 272943010364 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272943010365 trimer interface [polypeptide binding]; other site 272943010366 active site 272943010367 substrate binding site [chemical binding]; other site 272943010368 CoA binding site [chemical binding]; other site 272943010369 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272943010370 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272943010371 classical (c) SDRs; Region: SDR_c; cd05233 272943010372 NAD(P) binding site [chemical binding]; other site 272943010373 active site 272943010374 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272943010375 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272943010376 acyl-activating enzyme (AAE) consensus motif; other site 272943010377 active site 272943010378 AMP binding site [chemical binding]; other site 272943010379 CoA binding site [chemical binding]; other site 272943010380 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272943010381 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272943010382 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272943010383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943010384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943010385 putative substrate translocation pore; other site 272943010386 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 272943010387 Predicted periplasmic protein [Function unknown]; Region: COG3904 272943010388 Predicted flavoprotein [General function prediction only]; Region: COG0431 272943010389 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 272943010390 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 272943010391 MOFRL family; Region: MOFRL; pfam05161 272943010392 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272943010393 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272943010394 NAD(P) binding site [chemical binding]; other site 272943010395 putative active site [active] 272943010396 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272943010397 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 272943010398 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272943010399 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 272943010400 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 272943010401 DinB superfamily; Region: DinB_2; pfam12867 272943010402 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 272943010403 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 272943010404 Methyltransferase domain; Region: Methyltransf_25; pfam13649 272943010405 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 272943010406 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 272943010407 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 272943010408 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 272943010409 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 272943010410 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272943010411 putative ligand binding residues [chemical binding]; other site 272943010412 BCCT family transporter; Region: BCCT; pfam02028 272943010413 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272943010414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943010415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943010416 Walker A/P-loop; other site 272943010417 ATP binding site [chemical binding]; other site 272943010418 Q-loop/lid; other site 272943010419 ABC transporter signature motif; other site 272943010420 Walker B; other site 272943010421 D-loop; other site 272943010422 H-loop/switch region; other site 272943010423 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 272943010424 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272943010425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943010426 dimerization interface [polypeptide binding]; other site 272943010427 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272943010428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943010429 dimer interface [polypeptide binding]; other site 272943010430 putative CheW interface [polypeptide binding]; other site 272943010431 putative metal dependent hydrolase; Provisional; Region: PRK11598 272943010432 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 272943010433 Sulfatase; Region: Sulfatase; pfam00884 272943010434 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 272943010435 putative active site [active] 272943010436 trimer interface [polypeptide binding]; other site 272943010437 putative active site [active] 272943010438 Zn binding site [ion binding]; other site 272943010439 sensor protein QseC; Provisional; Region: PRK10337 272943010440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943010441 dimer interface [polypeptide binding]; other site 272943010442 phosphorylation site [posttranslational modification] 272943010443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943010444 ATP binding site [chemical binding]; other site 272943010445 Mg2+ binding site [ion binding]; other site 272943010446 G-X-G motif; other site 272943010447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943010448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943010449 active site 272943010450 phosphorylation site [posttranslational modification] 272943010451 intermolecular recognition site; other site 272943010452 dimerization interface [polypeptide binding]; other site 272943010453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943010454 DNA binding site [nucleotide binding] 272943010455 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272943010456 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272943010457 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272943010458 PhnA protein; Region: PhnA; pfam03831 272943010459 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 272943010460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 272943010461 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 272943010462 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272943010463 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 272943010464 RNA polymerase sigma factor; Provisional; Region: PRK12511 272943010465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943010466 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272943010467 DNA binding residues [nucleotide binding] 272943010468 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272943010469 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272943010470 D-pathway; other site 272943010471 Putative ubiquinol binding site [chemical binding]; other site 272943010472 Low-spin heme (heme b) binding site [chemical binding]; other site 272943010473 Putative water exit pathway; other site 272943010474 Binuclear center (heme o3/CuB) [ion binding]; other site 272943010475 K-pathway; other site 272943010476 Putative proton exit pathway; other site 272943010477 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 272943010478 Cupredoxin superfamily; Region: Cupredoxin; cl19115 272943010479 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 272943010480 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 272943010481 CHASE4 domain; Region: CHASE4; pfam05228 272943010482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943010483 metal binding site [ion binding]; metal-binding site 272943010484 active site 272943010485 I-site; other site 272943010486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943010487 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 272943010488 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 272943010489 putative hydrophobic ligand binding site [chemical binding]; other site 272943010490 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272943010491 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272943010492 NAD binding site [chemical binding]; other site 272943010493 catalytic Zn binding site [ion binding]; other site 272943010494 structural Zn binding site [ion binding]; other site 272943010495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943010496 PAS fold; Region: PAS_3; pfam08447 272943010497 putative active site [active] 272943010498 heme pocket [chemical binding]; other site 272943010499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943010500 PAS fold; Region: PAS_3; pfam08447 272943010501 putative active site [active] 272943010502 heme pocket [chemical binding]; other site 272943010503 PAS domain S-box; Region: sensory_box; TIGR00229 272943010504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943010505 PAS fold; Region: PAS_3; pfam08447 272943010506 putative active site [active] 272943010507 heme pocket [chemical binding]; other site 272943010508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943010509 HWE histidine kinase; Region: HWE_HK; pfam07536 272943010510 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272943010511 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 272943010512 putative metal binding site [ion binding]; other site 272943010513 putative homodimer interface [polypeptide binding]; other site 272943010514 putative homotetramer interface [polypeptide binding]; other site 272943010515 putative homodimer-homodimer interface [polypeptide binding]; other site 272943010516 putative allosteric switch controlling residues; other site 272943010517 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272943010518 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272943010519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943010520 dimerization interface [polypeptide binding]; other site 272943010521 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943010522 dimer interface [polypeptide binding]; other site 272943010523 putative CheW interface [polypeptide binding]; other site 272943010524 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272943010525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272943010526 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272943010527 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272943010528 C-terminal domain interface [polypeptide binding]; other site 272943010529 GSH binding site (G-site) [chemical binding]; other site 272943010530 dimer interface [polypeptide binding]; other site 272943010531 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272943010532 N-terminal domain interface [polypeptide binding]; other site 272943010533 dimer interface [polypeptide binding]; other site 272943010534 substrate binding pocket (H-site) [chemical binding]; other site 272943010535 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272943010536 putative C-terminal domain interface [polypeptide binding]; other site 272943010537 putative GSH binding site (G-site) [chemical binding]; other site 272943010538 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272943010539 putative dimer interface [polypeptide binding]; other site 272943010540 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 272943010541 dimer interface [polypeptide binding]; other site 272943010542 N-terminal domain interface [polypeptide binding]; other site 272943010543 putative substrate binding pocket (H-site) [chemical binding]; other site 272943010544 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272943010545 dimer interface [polypeptide binding]; other site 272943010546 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 272943010547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943010548 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 272943010549 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 272943010550 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272943010551 YodA lipocalin-like domain; Region: YodA; pfam09223 272943010552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 272943010553 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 272943010554 Serine hydrolase; Region: Ser_hydrolase; pfam06821 272943010555 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272943010556 Predicted membrane protein [Function unknown]; Region: COG2259 272943010557 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 272943010558 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 272943010559 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 272943010560 putative dimer interface [polypeptide binding]; other site 272943010561 N-terminal domain interface [polypeptide binding]; other site 272943010562 putative substrate binding pocket (H-site) [chemical binding]; other site 272943010563 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 272943010564 putative active site [active] 272943010565 metal binding site [ion binding]; metal-binding site 272943010566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943010567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943010568 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272943010569 putative effector binding pocket; other site 272943010570 dimerization interface [polypeptide binding]; other site 272943010571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943010572 dimerization interface [polypeptide binding]; other site 272943010573 putative DNA binding site [nucleotide binding]; other site 272943010574 putative Zn2+ binding site [ion binding]; other site 272943010575 Sodium Bile acid symporter family; Region: SBF; cl19217 272943010576 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272943010577 catalytic residues [active] 272943010578 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272943010579 active site 272943010580 ATP binding site [chemical binding]; other site 272943010581 substrate binding site [chemical binding]; other site 272943010582 activation loop (A-loop); other site 272943010583 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272943010584 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272943010585 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272943010586 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272943010587 phosphopeptide binding site; other site 272943010588 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 272943010589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943010590 Walker A/P-loop; other site 272943010591 ATP binding site [chemical binding]; other site 272943010592 Q-loop/lid; other site 272943010593 ABC transporter signature motif; other site 272943010594 Walker B; other site 272943010595 D-loop; other site 272943010596 H-loop/switch region; other site 272943010597 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 272943010598 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272943010599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272943010600 active site 272943010601 ATP binding site [chemical binding]; other site 272943010602 substrate binding site [chemical binding]; other site 272943010603 activation loop (A-loop); other site 272943010604 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272943010605 metal ion-dependent adhesion site (MIDAS); other site 272943010606 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 272943010607 Protein of unknown function (DUF642); Region: DUF642; cl19911 272943010608 Protein of unknown function (DUF642); Region: DUF642; cl19911 272943010609 hypothetical protein; Provisional; Region: PRK09897 272943010610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 272943010611 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272943010612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 272943010613 Protein of unknown function, DUF485; Region: DUF485; pfam04341 272943010614 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272943010615 Na binding site [ion binding]; other site 272943010616 NIPSNAP; Region: NIPSNAP; pfam07978 272943010617 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 272943010618 Fumarase C-terminus; Region: Fumerase_C; cl00795 272943010619 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 272943010620 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 272943010621 L-aspartate oxidase; Provisional; Region: PRK06175 272943010622 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272943010623 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 272943010624 Iron-sulfur protein interface; other site 272943010625 proximal heme binding site [chemical binding]; other site 272943010626 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 272943010627 Iron-sulfur protein interface; other site 272943010628 proximal heme binding site [chemical binding]; other site 272943010629 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 272943010630 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272943010631 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943010632 catalytic loop [active] 272943010633 iron binding site [ion binding]; other site 272943010634 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272943010635 NMT1-like family; Region: NMT1_2; pfam13379 272943010636 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272943010637 NMT1-like family; Region: NMT1_2; pfam13379 272943010638 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272943010639 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943010640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010641 dimer interface [polypeptide binding]; other site 272943010642 conserved gate region; other site 272943010643 putative PBP binding loops; other site 272943010644 ABC-ATPase subunit interface; other site 272943010645 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272943010646 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272943010647 Walker A/P-loop; other site 272943010648 ATP binding site [chemical binding]; other site 272943010649 Q-loop/lid; other site 272943010650 ABC transporter signature motif; other site 272943010651 Walker B; other site 272943010652 D-loop; other site 272943010653 H-loop/switch region; other site 272943010654 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 272943010655 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272943010656 PYR/PP interface [polypeptide binding]; other site 272943010657 dimer interface [polypeptide binding]; other site 272943010658 TPP binding site [chemical binding]; other site 272943010659 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272943010660 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272943010661 TPP-binding site [chemical binding]; other site 272943010662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943010663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943010664 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 272943010665 putative dimerization interface [polypeptide binding]; other site 272943010666 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943010667 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272943010668 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272943010669 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272943010670 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272943010671 Walker A/P-loop; other site 272943010672 ATP binding site [chemical binding]; other site 272943010673 Q-loop/lid; other site 272943010674 ABC transporter signature motif; other site 272943010675 Walker B; other site 272943010676 D-loop; other site 272943010677 H-loop/switch region; other site 272943010678 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272943010679 Walker A/P-loop; other site 272943010680 ATP binding site [chemical binding]; other site 272943010681 Q-loop/lid; other site 272943010682 ABC transporter signature motif; other site 272943010683 Walker B; other site 272943010684 D-loop; other site 272943010685 H-loop/switch region; other site 272943010686 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272943010687 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272943010688 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272943010689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272943010690 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943010691 Predicted integral membrane protein [Function unknown]; Region: COG0392 272943010692 Uncharacterized conserved protein [Function unknown]; Region: COG2898 272943010693 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 272943010694 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272943010695 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272943010696 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272943010697 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272943010698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943010699 catalytic loop [active] 272943010700 iron binding site [ion binding]; other site 272943010701 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272943010702 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943010703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943010704 DNA-binding site [nucleotide binding]; DNA binding site 272943010705 FCD domain; Region: FCD; pfam07729 272943010706 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272943010707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010708 dimer interface [polypeptide binding]; other site 272943010709 conserved gate region; other site 272943010710 putative PBP binding loops; other site 272943010711 ABC-ATPase subunit interface; other site 272943010712 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272943010713 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272943010714 Walker A/P-loop; other site 272943010715 ATP binding site [chemical binding]; other site 272943010716 Q-loop/lid; other site 272943010717 ABC transporter signature motif; other site 272943010718 Walker B; other site 272943010719 D-loop; other site 272943010720 H-loop/switch region; other site 272943010721 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272943010722 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943010723 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272943010724 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272943010725 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 272943010726 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272943010727 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 272943010728 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 272943010729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943010730 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272943010731 Na binding site [ion binding]; other site 272943010732 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 272943010733 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272943010734 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272943010735 NAD binding site [chemical binding]; other site 272943010736 homotetramer interface [polypeptide binding]; other site 272943010737 homodimer interface [polypeptide binding]; other site 272943010738 substrate binding site [chemical binding]; other site 272943010739 active site 272943010740 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 272943010741 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272943010742 dimer interface [polypeptide binding]; other site 272943010743 active site 272943010744 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 272943010745 active site 2 [active] 272943010746 active site 1 [active] 272943010747 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272943010748 metal binding site 2 [ion binding]; metal-binding site 272943010749 putative DNA binding helix; other site 272943010750 metal binding site 1 [ion binding]; metal-binding site 272943010751 dimer interface [polypeptide binding]; other site 272943010752 structural Zn2+ binding site [ion binding]; other site 272943010753 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272943010754 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272943010755 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 272943010756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272943010757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272943010758 active site 272943010759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943010760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943010761 NAD(P) binding site [chemical binding]; other site 272943010762 active site 272943010763 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 272943010764 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272943010765 dimer interface [polypeptide binding]; other site 272943010766 active site 272943010767 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 272943010768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943010769 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272943010770 conserved cys residue [active] 272943010771 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 272943010772 ApbE family; Region: ApbE; pfam02424 272943010773 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 272943010774 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 272943010775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943010776 catalytic loop [active] 272943010777 iron binding site [ion binding]; other site 272943010778 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272943010779 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272943010780 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272943010781 electron transport complex protein RsxA; Provisional; Region: PRK05151 272943010782 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 272943010783 Putative Fe-S cluster; Region: FeS; pfam04060 272943010784 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272943010785 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 272943010786 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 272943010787 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272943010788 SLBB domain; Region: SLBB; pfam10531 272943010789 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272943010790 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 272943010791 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 272943010792 electron transport complex RsxE subunit; Provisional; Region: PRK12405 272943010793 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 272943010794 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 272943010795 putative chaperone; Provisional; Region: PRK11678 272943010796 nucleotide binding site [chemical binding]; other site 272943010797 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272943010798 SBD interface [polypeptide binding]; other site 272943010799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272943010800 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272943010801 active site 272943010802 catalytic tetrad [active] 272943010803 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272943010804 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272943010805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943010806 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272943010807 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 272943010808 conserved cys residue [active] 272943010809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943010810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943010811 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272943010812 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943010813 catalytic loop [active] 272943010814 iron binding site [ion binding]; other site 272943010815 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272943010816 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 272943010817 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272943010818 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272943010819 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272943010820 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272943010821 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272943010822 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 272943010823 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 272943010824 cobalt transport protein CbiM; Validated; Region: PRK06265 272943010825 Cobalt transport protein; Region: CbiQ; cl00463 272943010826 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272943010827 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 272943010828 Walker A/P-loop; other site 272943010829 ATP binding site [chemical binding]; other site 272943010830 Q-loop/lid; other site 272943010831 ABC transporter signature motif; other site 272943010832 Walker B; other site 272943010833 D-loop; other site 272943010834 H-loop/switch region; other site 272943010835 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 272943010836 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272943010837 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272943010838 AAA domain; Region: AAA_27; pfam13514 272943010839 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272943010840 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272943010841 active site 272943010842 metal binding site [ion binding]; metal-binding site 272943010843 DNA binding site [nucleotide binding] 272943010844 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 272943010845 putative FMN binding site [chemical binding]; other site 272943010846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272943010847 ABC-ATPase subunit interface; other site 272943010848 dimer interface [polypeptide binding]; other site 272943010849 putative PBP binding regions; other site 272943010850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272943010851 ABC-ATPase subunit interface; other site 272943010852 dimer interface [polypeptide binding]; other site 272943010853 putative PBP binding regions; other site 272943010854 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 272943010855 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272943010856 Walker A/P-loop; other site 272943010857 ATP binding site [chemical binding]; other site 272943010858 Q-loop/lid; other site 272943010859 ABC transporter signature motif; other site 272943010860 Walker B; other site 272943010861 D-loop; other site 272943010862 H-loop/switch region; other site 272943010863 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 272943010864 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272943010865 N-terminal plug; other site 272943010866 ligand-binding site [chemical binding]; other site 272943010867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943010868 Histidine kinase; Region: HisKA_2; pfam07568 272943010869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943010870 ATP binding site [chemical binding]; other site 272943010871 Mg2+ binding site [ion binding]; other site 272943010872 G-X-G motif; other site 272943010873 NAD-dependent deacetylase; Provisional; Region: PRK00481 272943010874 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 272943010875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943010876 FeS/SAM binding site; other site 272943010877 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 272943010878 Cupin domain; Region: Cupin_2; cl17218 272943010879 lytic murein transglycosylase; Region: MltB_2; TIGR02283 272943010880 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272943010881 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943010882 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 272943010883 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 272943010884 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 272943010885 peptide binding site [polypeptide binding]; other site 272943010886 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943010887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010888 dimer interface [polypeptide binding]; other site 272943010889 conserved gate region; other site 272943010890 putative PBP binding loops; other site 272943010891 ABC-ATPase subunit interface; other site 272943010892 dipeptide transporter; Provisional; Region: PRK10913 272943010893 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943010894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010895 dimer interface [polypeptide binding]; other site 272943010896 conserved gate region; other site 272943010897 putative PBP binding loops; other site 272943010898 ABC-ATPase subunit interface; other site 272943010899 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272943010900 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010901 Walker A/P-loop; other site 272943010902 ATP binding site [chemical binding]; other site 272943010903 Q-loop/lid; other site 272943010904 ABC transporter signature motif; other site 272943010905 Walker B; other site 272943010906 D-loop; other site 272943010907 H-loop/switch region; other site 272943010908 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272943010909 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272943010910 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010911 Walker A/P-loop; other site 272943010912 ATP binding site [chemical binding]; other site 272943010913 Q-loop/lid; other site 272943010914 ABC transporter signature motif; other site 272943010915 Walker B; other site 272943010916 D-loop; other site 272943010917 H-loop/switch region; other site 272943010918 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943010919 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272943010920 dimer interface [polypeptide binding]; other site 272943010921 active site 272943010922 metal binding site [ion binding]; metal-binding site 272943010923 glutathione binding site [chemical binding]; other site 272943010924 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 272943010925 heterodimer interface [polypeptide binding]; other site 272943010926 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272943010927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943010928 dimerization interface [polypeptide binding]; other site 272943010929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943010930 dimer interface [polypeptide binding]; other site 272943010931 phosphorylation site [posttranslational modification] 272943010932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943010933 ATP binding site [chemical binding]; other site 272943010934 Mg2+ binding site [ion binding]; other site 272943010935 G-X-G motif; other site 272943010936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943010937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943010938 active site 272943010939 phosphorylation site [posttranslational modification] 272943010940 intermolecular recognition site; other site 272943010941 dimerization interface [polypeptide binding]; other site 272943010942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943010943 DNA binding site [nucleotide binding] 272943010944 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272943010945 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272943010946 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272943010947 protein binding site [polypeptide binding]; other site 272943010948 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272943010949 protein binding site [polypeptide binding]; other site 272943010950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272943010951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272943010952 putative substrate translocation pore; other site 272943010953 D-aminopeptidase; Reviewed; Region: PRK13128 272943010954 Beta-lactamase; Region: Beta-lactamase; pfam00144 272943010955 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 272943010956 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 272943010957 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943010958 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272943010959 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272943010960 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010961 Walker A/P-loop; other site 272943010962 ATP binding site [chemical binding]; other site 272943010963 Q-loop/lid; other site 272943010964 ABC transporter signature motif; other site 272943010965 Walker B; other site 272943010966 D-loop; other site 272943010967 H-loop/switch region; other site 272943010968 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943010969 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010970 Walker A/P-loop; other site 272943010971 ATP binding site [chemical binding]; other site 272943010972 Q-loop/lid; other site 272943010973 ABC transporter signature motif; other site 272943010974 Walker B; other site 272943010975 D-loop; other site 272943010976 H-loop/switch region; other site 272943010977 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272943010978 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272943010979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010980 dimer interface [polypeptide binding]; other site 272943010981 conserved gate region; other site 272943010982 putative PBP binding loops; other site 272943010983 ABC-ATPase subunit interface; other site 272943010984 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943010985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943010986 dimer interface [polypeptide binding]; other site 272943010987 conserved gate region; other site 272943010988 putative PBP binding loops; other site 272943010989 ABC-ATPase subunit interface; other site 272943010990 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272943010991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943010992 Walker A/P-loop; other site 272943010993 ATP binding site [chemical binding]; other site 272943010994 Q-loop/lid; other site 272943010995 ABC transporter signature motif; other site 272943010996 Walker B; other site 272943010997 D-loop; other site 272943010998 H-loop/switch region; other site 272943010999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943011000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943011001 Walker A/P-loop; other site 272943011002 ATP binding site [chemical binding]; other site 272943011003 Q-loop/lid; other site 272943011004 ABC transporter signature motif; other site 272943011005 Walker B; other site 272943011006 D-loop; other site 272943011007 H-loop/switch region; other site 272943011008 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272943011009 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 272943011010 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272943011011 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 272943011012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943011013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011014 dimer interface [polypeptide binding]; other site 272943011015 conserved gate region; other site 272943011016 putative PBP binding loops; other site 272943011017 ABC-ATPase subunit interface; other site 272943011018 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272943011019 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943011020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011021 dimer interface [polypeptide binding]; other site 272943011022 conserved gate region; other site 272943011023 putative PBP binding loops; other site 272943011024 ABC-ATPase subunit interface; other site 272943011025 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 272943011026 ANTAR domain; Region: ANTAR; pfam03861 272943011027 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272943011028 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943011029 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943011030 inhibitor-cofactor binding pocket; inhibition site 272943011031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943011032 catalytic residue [active] 272943011033 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272943011034 active site 272943011035 Uncharacterized Cupredoxin-like subfamily; Region: Cupredoxin_like_2; cd04211 272943011036 putative Type 1 (T1) Cu binding site [ion binding]; other site 272943011037 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272943011038 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 272943011039 AMP binding site [chemical binding]; other site 272943011040 metal binding site [ion binding]; metal-binding site 272943011041 active site 272943011042 phosphoribulokinase; Provisional; Region: PRK15453 272943011043 active site 272943011044 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272943011045 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272943011046 TPP-binding site [chemical binding]; other site 272943011047 dimer interface [polypeptide binding]; other site 272943011048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272943011049 PYR/PP interface [polypeptide binding]; other site 272943011050 dimer interface [polypeptide binding]; other site 272943011051 TPP binding site [chemical binding]; other site 272943011052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272943011053 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272943011054 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272943011055 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272943011056 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272943011057 intersubunit interface [polypeptide binding]; other site 272943011058 active site 272943011059 zinc binding site [ion binding]; other site 272943011060 Na+ binding site [ion binding]; other site 272943011061 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 272943011062 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 272943011063 dimer interface [polypeptide binding]; other site 272943011064 active site 272943011065 catalytic residue [active] 272943011066 metal binding site [ion binding]; metal-binding site 272943011067 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272943011068 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272943011069 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272943011070 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272943011071 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272943011072 Walker A/P-loop; other site 272943011073 ATP binding site [chemical binding]; other site 272943011074 Q-loop/lid; other site 272943011075 ABC transporter signature motif; other site 272943011076 Walker B; other site 272943011077 D-loop; other site 272943011078 H-loop/switch region; other site 272943011079 MoxR-like ATPases [General function prediction only]; Region: COG0714 272943011080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943011081 Walker A motif; other site 272943011082 ATP binding site [chemical binding]; other site 272943011083 Walker B motif; other site 272943011084 arginine finger; other site 272943011085 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272943011086 Protein of unknown function DUF58; Region: DUF58; pfam01882 272943011087 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272943011088 metal ion-dependent adhesion site (MIDAS); other site 272943011089 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272943011090 metal ion-dependent adhesion site (MIDAS); other site 272943011091 TPR repeat; Region: TPR_11; pfam13414 272943011092 Oxygen tolerance; Region: BatD; pfam13584 272943011093 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272943011094 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272943011095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272943011096 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 272943011097 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272943011098 PYR/PP interface [polypeptide binding]; other site 272943011099 dimer interface [polypeptide binding]; other site 272943011100 TPP binding site [chemical binding]; other site 272943011101 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272943011102 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272943011103 TPP-binding site [chemical binding]; other site 272943011104 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272943011105 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272943011106 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 272943011107 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272943011108 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943011109 Walker A/P-loop; other site 272943011110 ATP binding site [chemical binding]; other site 272943011111 Q-loop/lid; other site 272943011112 ABC transporter signature motif; other site 272943011113 Walker B; other site 272943011114 D-loop; other site 272943011115 H-loop/switch region; other site 272943011116 TOBE domain; Region: TOBE_2; pfam08402 272943011117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943011118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011119 dimer interface [polypeptide binding]; other site 272943011120 conserved gate region; other site 272943011121 putative PBP binding loops; other site 272943011122 ABC-ATPase subunit interface; other site 272943011123 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272943011124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011125 dimer interface [polypeptide binding]; other site 272943011126 conserved gate region; other site 272943011127 putative PBP binding loops; other site 272943011128 ABC-ATPase subunit interface; other site 272943011129 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943011130 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272943011131 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 272943011132 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272943011133 PhoU domain; Region: PhoU; pfam01895 272943011134 choline dehydrogenase; Validated; Region: PRK02106 272943011135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943011136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943011137 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272943011138 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272943011139 TM-ABC transporter signature motif; other site 272943011140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272943011141 TM-ABC transporter signature motif; other site 272943011142 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272943011143 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272943011144 Walker A/P-loop; other site 272943011145 ATP binding site [chemical binding]; other site 272943011146 Q-loop/lid; other site 272943011147 ABC transporter signature motif; other site 272943011148 Walker B; other site 272943011149 D-loop; other site 272943011150 H-loop/switch region; other site 272943011151 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943011152 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272943011153 Walker A/P-loop; other site 272943011154 ATP binding site [chemical binding]; other site 272943011155 Q-loop/lid; other site 272943011156 ABC transporter signature motif; other site 272943011157 Walker B; other site 272943011158 D-loop; other site 272943011159 H-loop/switch region; other site 272943011160 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 272943011161 putative ligand binding site [chemical binding]; other site 272943011162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943011163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943011164 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272943011165 dimerization interface [polypeptide binding]; other site 272943011166 MAEBL; Provisional; Region: PTZ00121 272943011167 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943011168 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272943011169 metal ion-dependent adhesion site (MIDAS); other site 272943011170 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272943011171 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272943011172 active site 272943011173 intersubunit interface [polypeptide binding]; other site 272943011174 catalytic residue [active] 272943011175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943011176 active site 272943011177 phosphorylation site [posttranslational modification] 272943011178 intermolecular recognition site; other site 272943011179 dimerization interface [polypeptide binding]; other site 272943011180 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272943011181 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272943011182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943011183 dimerization interface [polypeptide binding]; other site 272943011184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943011185 dimer interface [polypeptide binding]; other site 272943011186 putative CheW interface [polypeptide binding]; other site 272943011187 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272943011188 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 272943011189 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 272943011190 EamA-like transporter family; Region: EamA; pfam00892 272943011191 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272943011192 EamA-like transporter family; Region: EamA; pfam00892 272943011193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943011194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272943011195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943011196 Winged helix-turn helix; Region: HTH_29; pfam13551 272943011197 Helix-turn-helix domain; Region: HTH_28; pfam13518 272943011198 Homeodomain-like domain; Region: HTH_32; pfam13565 272943011199 Integrase core domain; Region: rve; pfam00665 272943011200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272943011201 active site 272943011202 Int/Topo IB signature motif; other site 272943011203 DNA binding site [nucleotide binding] 272943011204 OTU-like cysteine protease; Region: OTU; cl19932 272943011205 MT-A70; Region: MT-A70; cl01947 272943011206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943011207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943011208 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272943011209 MMPL family; Region: MMPL; cl14618 272943011210 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272943011211 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 272943011212 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943011213 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272943011214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943011215 Walker A motif; other site 272943011216 ATP binding site [chemical binding]; other site 272943011217 Walker B motif; other site 272943011218 arginine finger; other site 272943011219 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272943011220 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 272943011221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272943011222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943011223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943011224 DNA binding residues [nucleotide binding] 272943011225 dimerization interface [polypeptide binding]; other site 272943011226 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 272943011227 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272943011228 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272943011229 active site 272943011230 Rhomboid family; Region: Rhomboid; cl11446 272943011231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272943011232 Protein of unknown function (DUF465); Region: DUF465; pfam04325 272943011233 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 272943011234 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272943011235 transmembrane helices; other site 272943011236 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272943011237 TrkA-C domain; Region: TrkA_C; pfam02080 272943011238 TrkA-C domain; Region: TrkA_C; pfam02080 272943011239 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 272943011240 LrgB-like family; Region: LrgB; cl00596 272943011241 LrgA family; Region: LrgA; pfam03788 272943011242 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272943011243 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943011244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011245 dimer interface [polypeptide binding]; other site 272943011246 conserved gate region; other site 272943011247 putative PBP binding loops; other site 272943011248 ABC-ATPase subunit interface; other site 272943011249 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943011250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011251 dimer interface [polypeptide binding]; other site 272943011252 conserved gate region; other site 272943011253 putative PBP binding loops; other site 272943011254 ABC-ATPase subunit interface; other site 272943011255 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943011256 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943011257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943011258 Walker A/P-loop; other site 272943011259 ATP binding site [chemical binding]; other site 272943011260 Q-loop/lid; other site 272943011261 ABC transporter signature motif; other site 272943011262 Walker B; other site 272943011263 D-loop; other site 272943011264 H-loop/switch region; other site 272943011265 TOBE domain; Region: TOBE_2; pfam08402 272943011266 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943011267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943011268 DNA-binding site [nucleotide binding]; DNA binding site 272943011269 FCD domain; Region: FCD; pfam07729 272943011270 Rrf2 family protein; Region: rrf2_super; TIGR00738 272943011271 Transcriptional regulator; Region: Rrf2; cl17282 272943011272 Predicted permeases [General function prediction only]; Region: RarD; COG2962 272943011273 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 272943011274 Ferritin-like domain; Region: Ferritin; pfam00210 272943011275 heme binding site [chemical binding]; other site 272943011276 ferroxidase pore; other site 272943011277 ferroxidase diiron center [ion binding]; other site 272943011278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943011279 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943011280 PAS domain; Region: PAS_9; pfam13426 272943011281 PAS domain; Region: PAS_9; pfam13426 272943011282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943011283 metal binding site [ion binding]; metal-binding site 272943011284 active site 272943011285 I-site; other site 272943011286 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272943011287 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 272943011288 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 272943011289 substrate binding pocket [chemical binding]; other site 272943011290 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272943011291 B12 binding site [chemical binding]; other site 272943011292 cobalt ligand [ion binding]; other site 272943011293 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272943011294 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272943011295 Phage tail tube protein FII; Region: Phage_tube; pfam04985 272943011296 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 272943011297 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 272943011298 Mu-like prophage protein [General function prediction only]; Region: COG3941 272943011299 tape measure domain; Region: tape_meas_nterm; TIGR02675 272943011300 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 272943011301 Phage Tail Protein X; Region: Phage_tail_X; cl02088 272943011302 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 272943011303 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272943011304 Uncharacterized conserved protein [Function unknown]; Region: COG4748 272943011305 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272943011306 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 272943011307 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 272943011308 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272943011309 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 272943011310 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272943011311 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 272943011312 dimer interface [polypeptide binding]; other site 272943011313 putative tRNA-binding site [nucleotide binding]; other site 272943011314 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272943011315 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 272943011316 dimerization interface [polypeptide binding]; other site 272943011317 ligand binding site [chemical binding]; other site 272943011318 NADP binding site [chemical binding]; other site 272943011319 catalytic site [active] 272943011320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943011321 dimerization interface [polypeptide binding]; other site 272943011322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943011323 metal binding site [ion binding]; metal-binding site 272943011324 active site 272943011325 I-site; other site 272943011326 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272943011327 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272943011328 DctM-like transporters; Region: DctM; pfam06808 272943011329 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 272943011330 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943011331 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272943011332 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272943011333 FtsX-like permease family; Region: FtsX; pfam02687 272943011334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272943011335 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272943011336 Walker A/P-loop; other site 272943011337 ATP binding site [chemical binding]; other site 272943011338 Q-loop/lid; other site 272943011339 ABC transporter signature motif; other site 272943011340 Walker B; other site 272943011341 D-loop; other site 272943011342 H-loop/switch region; other site 272943011343 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272943011344 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272943011345 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943011346 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272943011347 trimer interface [polypeptide binding]; other site 272943011348 active site 272943011349 dimer interface [polypeptide binding]; other site 272943011350 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 272943011351 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272943011352 putative C-terminal domain interface [polypeptide binding]; other site 272943011353 putative GSH binding site (G-site) [chemical binding]; other site 272943011354 putative dimer interface [polypeptide binding]; other site 272943011355 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 272943011356 putative N-terminal domain interface [polypeptide binding]; other site 272943011357 putative dimer interface [polypeptide binding]; other site 272943011358 putative substrate binding pocket (H-site) [chemical binding]; other site 272943011359 RES domain; Region: RES; pfam08808 272943011360 Bacterial SH3 domain; Region: SH3_3; pfam08239 272943011361 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 272943011362 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 272943011363 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 272943011364 NADP binding site [chemical binding]; other site 272943011365 dimer interface [polypeptide binding]; other site 272943011366 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272943011367 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272943011368 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 272943011369 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272943011370 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 272943011371 putative active site pocket [active] 272943011372 metal binding site [ion binding]; metal-binding site 272943011373 transcriptional activator TtdR; Provisional; Region: PRK09801 272943011374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943011375 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 272943011376 putative effector binding pocket; other site 272943011377 putative dimerization interface [polypeptide binding]; other site 272943011378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 272943011379 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 272943011380 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272943011381 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272943011382 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272943011383 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272943011384 Walker A/P-loop; other site 272943011385 ATP binding site [chemical binding]; other site 272943011386 Q-loop/lid; other site 272943011387 ABC transporter signature motif; other site 272943011388 Walker B; other site 272943011389 D-loop; other site 272943011390 H-loop/switch region; other site 272943011391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943011392 ABC-ATPase subunit interface; other site 272943011393 dimer interface [polypeptide binding]; other site 272943011394 putative PBP binding regions; other site 272943011395 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 272943011396 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272943011397 putative ligand binding residues [chemical binding]; other site 272943011398 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943011399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011400 dimer interface [polypeptide binding]; other site 272943011401 conserved gate region; other site 272943011402 putative PBP binding loops; other site 272943011403 ABC-ATPase subunit interface; other site 272943011404 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943011405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011406 dimer interface [polypeptide binding]; other site 272943011407 conserved gate region; other site 272943011408 putative PBP binding loops; other site 272943011409 ABC-ATPase subunit interface; other site 272943011410 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943011411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943011412 Walker A/P-loop; other site 272943011413 ATP binding site [chemical binding]; other site 272943011414 Q-loop/lid; other site 272943011415 ABC transporter signature motif; other site 272943011416 Walker B; other site 272943011417 D-loop; other site 272943011418 H-loop/switch region; other site 272943011419 TOBE domain; Region: TOBE_2; pfam08402 272943011420 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943011421 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 272943011422 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 272943011423 putative active site [active] 272943011424 catalytic triad [active] 272943011425 dimer interface [polypeptide binding]; other site 272943011426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943011427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943011428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272943011429 dimerization interface [polypeptide binding]; other site 272943011430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943011431 metal binding site [ion binding]; metal-binding site 272943011432 active site 272943011433 I-site; other site 272943011434 GAF domain; Region: GAF; pfam01590 272943011435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272943011436 PAS domain; Region: PAS_9; pfam13426 272943011437 putative active site [active] 272943011438 heme pocket [chemical binding]; other site 272943011439 PAS domain; Region: PAS; smart00091 272943011440 PAS domain; Region: PAS_9; pfam13426 272943011441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943011442 metal binding site [ion binding]; metal-binding site 272943011443 active site 272943011444 I-site; other site 272943011445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272943011446 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272943011447 putative active site [active] 272943011448 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 272943011449 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272943011450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943011451 DNA-binding site [nucleotide binding]; DNA binding site 272943011452 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272943011453 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 272943011454 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272943011455 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 272943011456 putative ligand binding site [chemical binding]; other site 272943011457 putative NAD binding site [chemical binding]; other site 272943011458 catalytic site [active] 272943011459 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272943011460 inhibitor site; inhibition site 272943011461 active site 272943011462 dimer interface [polypeptide binding]; other site 272943011463 catalytic residue [active] 272943011464 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 272943011465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 272943011466 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 272943011467 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 272943011468 active site 272943011469 NAD binding site [chemical binding]; other site 272943011470 metal binding site [ion binding]; metal-binding site 272943011471 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272943011472 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272943011473 Walker A/P-loop; other site 272943011474 ATP binding site [chemical binding]; other site 272943011475 Q-loop/lid; other site 272943011476 ABC transporter signature motif; other site 272943011477 Walker B; other site 272943011478 D-loop; other site 272943011479 H-loop/switch region; other site 272943011480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943011481 ABC-ATPase subunit interface; other site 272943011482 dimer interface [polypeptide binding]; other site 272943011483 putative PBP binding regions; other site 272943011484 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943011485 ABC-ATPase subunit interface; other site 272943011486 dimer interface [polypeptide binding]; other site 272943011487 putative PBP binding regions; other site 272943011488 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272943011489 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272943011490 siderophore binding site; other site 272943011491 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 272943011492 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272943011493 N-terminal plug; other site 272943011494 ligand-binding site [chemical binding]; other site 272943011495 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 272943011496 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 272943011497 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272943011498 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272943011499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943011500 dimer interface [polypeptide binding]; other site 272943011501 putative CheW interface [polypeptide binding]; other site 272943011502 Protein of unknown function (DUF390); Region: DUF390; pfam04094 272943011503 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272943011504 putative catalytic site [active] 272943011505 putative phosphate binding site [ion binding]; other site 272943011506 active site 272943011507 metal binding site A [ion binding]; metal-binding site 272943011508 DNA binding site [nucleotide binding] 272943011509 putative AP binding site [nucleotide binding]; other site 272943011510 putative metal binding site B [ion binding]; other site 272943011511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943011512 short chain dehydrogenase; Region: adh_short; pfam00106 272943011513 NAD(P) binding site [chemical binding]; other site 272943011514 active site 272943011515 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 272943011516 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 272943011517 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 272943011518 putative heme binding site [chemical binding]; other site 272943011519 putative substrate binding site [chemical binding]; other site 272943011520 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 272943011521 active site 272943011522 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272943011523 active site 272943011524 catalytic triad [active] 272943011525 oxyanion hole [active] 272943011526 Caspase domain; Region: Peptidase_C14; pfam00656 272943011527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943011528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943011529 active site 272943011530 phosphorylation site [posttranslational modification] 272943011531 intermolecular recognition site; other site 272943011532 dimerization interface [polypeptide binding]; other site 272943011533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943011534 DNA binding site [nucleotide binding] 272943011535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943011536 HAMP domain; Region: HAMP; pfam00672 272943011537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272943011538 dimer interface [polypeptide binding]; other site 272943011539 phosphorylation site [posttranslational modification] 272943011540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943011541 ATP binding site [chemical binding]; other site 272943011542 Mg2+ binding site [ion binding]; other site 272943011543 G-X-G motif; other site 272943011544 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272943011545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943011546 dimerization interface [polypeptide binding]; other site 272943011547 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272943011548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943011549 dimer interface [polypeptide binding]; other site 272943011550 putative CheW interface [polypeptide binding]; other site 272943011551 nickel responsive regulator; Provisional; Region: PRK02967 272943011552 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272943011553 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 272943011554 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 272943011555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943011556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943011557 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 272943011558 putative dimerization interface [polypeptide binding]; other site 272943011559 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 272943011560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943011561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943011562 homodimer interface [polypeptide binding]; other site 272943011563 catalytic residue [active] 272943011564 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 272943011565 homotrimer interaction site [polypeptide binding]; other site 272943011566 putative active site [active] 272943011567 aspartate aminotransferase; Provisional; Region: PRK05764 272943011568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272943011569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943011570 homodimer interface [polypeptide binding]; other site 272943011571 catalytic residue [active] 272943011572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943011573 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943011574 NAD(P) binding site [chemical binding]; other site 272943011575 active site 272943011576 hypothetical protein; Validated; Region: PRK08245 272943011577 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272943011578 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 272943011579 putative ligand binding site [chemical binding]; other site 272943011580 NAD binding site [chemical binding]; other site 272943011581 dimerization interface [polypeptide binding]; other site 272943011582 catalytic site [active] 272943011583 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl19826 272943011584 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272943011585 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272943011586 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272943011587 active site 272943011588 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 272943011589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943011590 DNA-binding site [nucleotide binding]; DNA binding site 272943011591 allantoate amidohydrolase; Reviewed; Region: PRK12890 272943011592 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272943011593 active site 272943011594 metal binding site [ion binding]; metal-binding site 272943011595 dimer interface [polypeptide binding]; other site 272943011596 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272943011597 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272943011598 NAD binding site [chemical binding]; other site 272943011599 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272943011600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943011601 DNA-binding site [nucleotide binding]; DNA binding site 272943011602 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272943011603 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 272943011604 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 272943011605 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272943011606 DctM-like transporters; Region: DctM; pfam06808 272943011607 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 272943011608 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943011609 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 272943011610 putative active site [active] 272943011611 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272943011612 homodimer interface [polypeptide binding]; other site 272943011613 substrate-cofactor binding pocket; other site 272943011614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943011615 catalytic residue [active] 272943011616 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272943011617 inhibitor site; inhibition site 272943011618 active site 272943011619 dimer interface [polypeptide binding]; other site 272943011620 catalytic residue [active] 272943011621 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272943011622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272943011623 substrate binding pocket [chemical binding]; other site 272943011624 membrane-bound complex binding site; other site 272943011625 hinge residues; other site 272943011626 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272943011627 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272943011628 Walker A/P-loop; other site 272943011629 ATP binding site [chemical binding]; other site 272943011630 Q-loop/lid; other site 272943011631 ABC transporter signature motif; other site 272943011632 Walker B; other site 272943011633 D-loop; other site 272943011634 H-loop/switch region; other site 272943011635 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272943011636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011637 dimer interface [polypeptide binding]; other site 272943011638 conserved gate region; other site 272943011639 putative PBP binding loops; other site 272943011640 ABC-ATPase subunit interface; other site 272943011641 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272943011642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011643 dimer interface [polypeptide binding]; other site 272943011644 conserved gate region; other site 272943011645 putative PBP binding loops; other site 272943011646 ABC-ATPase subunit interface; other site 272943011647 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 272943011648 tetramer interface [polypeptide binding]; other site 272943011649 active site 272943011650 catalytic triad [active] 272943011651 dimer interface [polypeptide binding]; other site 272943011652 dihydropyrimidinase; Provisional; Region: PRK13404 272943011653 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 272943011654 tetramer interface [polypeptide binding]; other site 272943011655 active site 272943011656 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272943011657 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 272943011658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943011659 dimerization interface [polypeptide binding]; other site 272943011660 putative Zn2+ binding site [ion binding]; other site 272943011661 putative DNA binding site [nucleotide binding]; other site 272943011662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943011663 dimerization interface [polypeptide binding]; other site 272943011664 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272943011665 conserved hypothetical protein; Region: TIGR02270 272943011666 Leishmanolysin; Region: Peptidase_M8; cl19482 272943011667 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 272943011668 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 272943011669 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 272943011670 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 272943011671 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 272943011672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943011673 Walker A motif; other site 272943011674 ATP binding site [chemical binding]; other site 272943011675 Walker B motif; other site 272943011676 arginine finger; other site 272943011677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943011678 Walker A motif; other site 272943011679 ATP binding site [chemical binding]; other site 272943011680 Walker B motif; other site 272943011681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272943011682 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272943011683 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272943011684 active site 272943011685 ATP binding site [chemical binding]; other site 272943011686 substrate binding site [chemical binding]; other site 272943011687 activation loop (A-loop); other site 272943011688 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 272943011689 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 272943011690 Protein of unknown function (DUF770); Region: DUF770; cl01402 272943011691 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 272943011692 Protein of unknown function (DUF796); Region: DUF796; pfam05638 272943011693 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 272943011694 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 272943011695 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 272943011696 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272943011697 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 272943011698 phosphopeptide binding site; other site 272943011699 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 272943011700 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 272943011701 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 272943011702 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943011703 ligand binding site [chemical binding]; other site 272943011704 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 272943011705 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 272943011706 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 272943011707 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 272943011708 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 272943011709 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 272943011710 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 272943011711 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 272943011712 Flagellin protein; Region: FliC; pfam12445 272943011713 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 272943011714 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 272943011715 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 272943011716 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 272943011717 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272943011718 active site 272943011719 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272943011720 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272943011721 ligand binding site [chemical binding]; other site 272943011722 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943011723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943011724 Caspase domain; Region: Peptidase_C14; pfam00656 272943011725 dimer interface [polypeptide binding]; other site 272943011726 substrate pocket [chemical binding]; other site 272943011727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272943011728 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272943011729 TPR motif; other site 272943011730 binding surface 272943011731 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272943011732 Sel1-like repeats; Region: SEL1; smart00671 272943011733 Sel1-like repeats; Region: SEL1; smart00671 272943011734 Sel1-like repeats; Region: SEL1; smart00671 272943011735 Sel1-like repeats; Region: SEL1; smart00671 272943011736 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272943011737 Sel1-like repeats; Region: SEL1; smart00671 272943011738 Uncharacterized conserved protein [Function unknown]; Region: COG3347 272943011739 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 272943011740 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272943011741 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272943011742 ligand binding site [chemical binding]; other site 272943011743 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943011744 TM-ABC transporter signature motif; other site 272943011745 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943011746 TM-ABC transporter signature motif; other site 272943011747 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 272943011748 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943011749 Walker A/P-loop; other site 272943011750 ATP binding site [chemical binding]; other site 272943011751 Q-loop/lid; other site 272943011752 ABC transporter signature motif; other site 272943011753 Walker B; other site 272943011754 D-loop; other site 272943011755 H-loop/switch region; other site 272943011756 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272943011757 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272943011758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272943011759 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272943011760 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 272943011761 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 272943011762 putative N- and C-terminal domain interface [polypeptide binding]; other site 272943011763 putative active site [active] 272943011764 putative MgATP binding site [chemical binding]; other site 272943011765 catalytic site [active] 272943011766 metal binding site [ion binding]; metal-binding site 272943011767 putative carbohydrate binding site [chemical binding]; other site 272943011768 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 272943011769 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl19826 272943011770 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943011771 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272943011772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272943011773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272943011774 active site 272943011775 phosphorylation site [posttranslational modification] 272943011776 intermolecular recognition site; other site 272943011777 dimerization interface [polypeptide binding]; other site 272943011778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272943011779 DNA binding site [nucleotide binding] 272943011780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272943011781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943011782 ATP binding site [chemical binding]; other site 272943011783 Mg2+ binding site [ion binding]; other site 272943011784 G-X-G motif; other site 272943011785 GAF domain; Region: GAF; pfam01590 272943011786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272943011787 metal binding site [ion binding]; metal-binding site 272943011788 active site 272943011789 I-site; other site 272943011790 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272943011791 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 272943011792 conserved cys residue [active] 272943011793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943011794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272943011795 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272943011796 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272943011797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943011798 Walker A/P-loop; other site 272943011799 ATP binding site [chemical binding]; other site 272943011800 Q-loop/lid; other site 272943011801 ABC transporter signature motif; other site 272943011802 Walker B; other site 272943011803 D-loop; other site 272943011804 H-loop/switch region; other site 272943011805 TOBE domain; Region: TOBE_2; pfam08402 272943011806 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943011807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011808 dimer interface [polypeptide binding]; other site 272943011809 conserved gate region; other site 272943011810 putative PBP binding loops; other site 272943011811 ABC-ATPase subunit interface; other site 272943011812 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272943011813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011814 dimer interface [polypeptide binding]; other site 272943011815 conserved gate region; other site 272943011816 putative PBP binding loops; other site 272943011817 ABC-ATPase subunit interface; other site 272943011818 proline racemase; Provisional; Region: PRK13969 272943011819 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 272943011820 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272943011821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943011822 Walker A/P-loop; other site 272943011823 ATP binding site [chemical binding]; other site 272943011824 Q-loop/lid; other site 272943011825 ABC transporter signature motif; other site 272943011826 Walker B; other site 272943011827 D-loop; other site 272943011828 H-loop/switch region; other site 272943011829 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943011830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943011831 Walker A/P-loop; other site 272943011832 ATP binding site [chemical binding]; other site 272943011833 Q-loop/lid; other site 272943011834 ABC transporter signature motif; other site 272943011835 Walker B; other site 272943011836 D-loop; other site 272943011837 H-loop/switch region; other site 272943011838 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943011839 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 272943011840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011841 dimer interface [polypeptide binding]; other site 272943011842 conserved gate region; other site 272943011843 putative PBP binding loops; other site 272943011844 ABC-ATPase subunit interface; other site 272943011845 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943011846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943011847 dimer interface [polypeptide binding]; other site 272943011848 conserved gate region; other site 272943011849 putative PBP binding loops; other site 272943011850 ABC-ATPase subunit interface; other site 272943011851 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943011852 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 272943011853 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943011854 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 272943011855 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 272943011856 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 272943011857 active site 272943011858 Zn binding site [ion binding]; other site 272943011859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943011860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943011861 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272943011862 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 272943011863 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 272943011864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943011865 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272943011866 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272943011867 acyl-activating enzyme (AAE) consensus motif; other site 272943011868 AMP binding site [chemical binding]; other site 272943011869 active site 272943011870 CoA binding site [chemical binding]; other site 272943011871 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 272943011872 NAD(P) binding site [chemical binding]; other site 272943011873 catalytic residues [active] 272943011874 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943011875 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943011876 inhibitor-cofactor binding pocket; inhibition site 272943011877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943011878 catalytic residue [active] 272943011879 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272943011880 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 272943011881 substrate binding site [chemical binding]; other site 272943011882 oxyanion hole (OAH) forming residues; other site 272943011883 trimer interface [polypeptide binding]; other site 272943011884 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272943011885 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272943011886 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 272943011887 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272943011888 dimer interface [polypeptide binding]; other site 272943011889 active site 272943011890 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 272943011891 Prostaglandin dehydrogenases; Region: PGDH; cd05288 272943011892 NAD(P) binding site [chemical binding]; other site 272943011893 substrate binding site [chemical binding]; other site 272943011894 dimer interface [polypeptide binding]; other site 272943011895 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272943011896 VCBS repeat; Region: VCBS_repeat; TIGR01965 272943011897 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943011898 Integrase core domain; Region: rve; pfam00665 272943011899 TIR domain; Region: TIR_2; pfam13676 272943011900 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 272943011901 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 272943011902 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 272943011903 active site 272943011904 dimer interface [polypeptide binding]; other site 272943011905 effector binding site; other site 272943011906 TSCPD domain; Region: TSCPD; pfam12637 272943011907 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 272943011908 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 272943011909 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 272943011910 motif 1; other site 272943011911 dimer interface [polypeptide binding]; other site 272943011912 active site 272943011913 motif 2; other site 272943011914 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272943011915 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272943011916 dimer interface [polypeptide binding]; other site 272943011917 motif 1; other site 272943011918 active site 272943011919 motif 2; other site 272943011920 motif 3; other site 272943011921 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272943011922 anticodon binding site; other site 272943011923 SlyX; Region: SlyX; pfam04102 272943011924 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272943011925 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 272943011926 putative active site [active] 272943011927 putative PHP Thumb interface [polypeptide binding]; other site 272943011928 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272943011929 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272943011930 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272943011931 generic binding surface II; other site 272943011932 generic binding surface I; other site 272943011933 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 272943011934 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272943011935 catalytic loop [active] 272943011936 iron binding site [ion binding]; other site 272943011937 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272943011938 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272943011939 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 272943011940 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 272943011941 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272943011942 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272943011943 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 272943011944 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272943011945 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272943011946 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943011947 Walker A/P-loop; other site 272943011948 ATP binding site [chemical binding]; other site 272943011949 Q-loop/lid; other site 272943011950 ABC transporter signature motif; other site 272943011951 Walker B; other site 272943011952 D-loop; other site 272943011953 H-loop/switch region; other site 272943011954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943011955 Walker A/P-loop; other site 272943011956 ATP binding site [chemical binding]; other site 272943011957 Q-loop/lid; other site 272943011958 ABC transporter signature motif; other site 272943011959 Walker B; other site 272943011960 D-loop; other site 272943011961 H-loop/switch region; other site 272943011962 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272943011963 TM-ABC transporter signature motif; other site 272943011964 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272943011965 TM-ABC transporter signature motif; other site 272943011966 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 272943011967 putative ligand binding site [chemical binding]; other site 272943011968 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272943011969 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272943011970 FAD dependent oxidoreductase; Region: DAO; pfam01266 272943011971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943011972 Protein of unknown function (DUF938); Region: DUF938; pfam06080 272943011973 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 272943011974 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272943011975 active site 272943011976 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272943011977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272943011978 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 272943011979 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 272943011980 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272943011981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943011982 ABC-ATPase subunit interface; other site 272943011983 dimer interface [polypeptide binding]; other site 272943011984 putative PBP binding regions; other site 272943011985 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272943011986 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272943011987 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 272943011988 metal binding site 2 [ion binding]; metal-binding site 272943011989 putative DNA binding helix; other site 272943011990 metal binding site 1 [ion binding]; metal-binding site 272943011991 dimer interface [polypeptide binding]; other site 272943011992 structural Zn2+ binding site [ion binding]; other site 272943011993 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272943011994 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 272943011995 metal binding site [ion binding]; metal-binding site 272943011996 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272943011997 active site 272943011998 catalytic residues [active] 272943011999 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 272943012000 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 272943012001 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 272943012002 active sites [active] 272943012003 tetramer interface [polypeptide binding]; other site 272943012004 Gas vesicle protein K; Region: GvpK; pfam05121 272943012005 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 272943012006 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 272943012007 Gas vesicle protein G; Region: GvpG; pfam05120 272943012008 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 272943012009 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272943012010 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272943012011 putative dimer interface [polypeptide binding]; other site 272943012012 Gas vesicle protein; Region: Gas_vesicle; pfam00741 272943012013 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 272943012014 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272943012015 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 272943012016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272943012017 Walker A motif; other site 272943012018 ATP binding site [chemical binding]; other site 272943012019 Walker B motif; other site 272943012020 Predicted membrane protein [Function unknown]; Region: COG3748 272943012021 Protein of unknown function (DUF989); Region: DUF989; pfam06181 272943012022 Cytochrome c; Region: Cytochrom_C; pfam00034 272943012023 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 272943012024 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272943012025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943012026 catalytic residue [active] 272943012027 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272943012028 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272943012029 active site 272943012030 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 272943012031 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 272943012032 dimer interface [polypeptide binding]; other site 272943012033 DNA binding site [nucleotide binding] 272943012034 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272943012035 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272943012036 RNA binding site [nucleotide binding]; other site 272943012037 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272943012038 RNA binding site [nucleotide binding]; other site 272943012039 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272943012040 RNA binding site [nucleotide binding]; other site 272943012041 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272943012042 RNA binding site [nucleotide binding]; other site 272943012043 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272943012044 RNA binding site [nucleotide binding]; other site 272943012045 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272943012046 RNA binding site [nucleotide binding]; other site 272943012047 cytidylate kinase; Provisional; Region: cmk; PRK00023 272943012048 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272943012049 CMP-binding site; other site 272943012050 The sites determining sugar specificity; other site 272943012051 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272943012052 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272943012053 hinge; other site 272943012054 active site 272943012055 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272943012056 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943012057 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272943012058 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272943012059 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272943012060 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272943012061 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 272943012062 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272943012063 putative active site [active] 272943012064 catalytic triad [active] 272943012065 putative dimer interface [polypeptide binding]; other site 272943012066 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 272943012067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272943012068 Transporter associated domain; Region: CorC_HlyC; smart01091 272943012069 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 272943012070 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272943012071 PhoH-like protein; Region: PhoH; pfam02562 272943012072 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 272943012073 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272943012074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272943012075 FeS/SAM binding site; other site 272943012076 TRAM domain; Region: TRAM; cl01282 272943012077 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 272943012078 active site 272943012079 catalytic triad [active] 272943012080 oxyanion hole [active] 272943012081 switch loop; other site 272943012082 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 272943012083 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272943012084 Walker A/P-loop; other site 272943012085 ATP binding site [chemical binding]; other site 272943012086 Q-loop/lid; other site 272943012087 ABC transporter signature motif; other site 272943012088 Walker B; other site 272943012089 D-loop; other site 272943012090 H-loop/switch region; other site 272943012091 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 272943012092 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272943012093 FtsX-like permease family; Region: FtsX; pfam02687 272943012094 FtsX-like permease family; Region: FtsX; pfam02687 272943012095 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 272943012096 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 272943012097 active site residue [active] 272943012098 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 272943012099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943012100 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272943012101 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 272943012102 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272943012103 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272943012104 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272943012105 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 272943012106 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272943012107 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272943012108 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272943012109 catalytic residues [active] 272943012110 catalytic nucleophile [active] 272943012111 Recombinase; Region: Recombinase; pfam07508 272943012112 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272943012113 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272943012114 ParB-like nuclease domain; Region: ParBc; pfam02195 272943012115 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272943012116 nuclear egress membrane protein; Provisional; Region: PHA03326 272943012117 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 272943012118 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 272943012119 Putative glucoamylase; Region: Glycoamylase; pfam10091 272943012120 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 272943012121 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 272943012122 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 272943012123 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272943012124 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272943012125 ring oligomerisation interface [polypeptide binding]; other site 272943012126 ATP/Mg binding site [chemical binding]; other site 272943012127 stacking interactions; other site 272943012128 hinge regions; other site 272943012129 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943012130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943012131 ligand binding site [chemical binding]; other site 272943012132 flexible hinge region; other site 272943012133 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272943012134 putative switch regulator; other site 272943012135 non-specific DNA interactions [nucleotide binding]; other site 272943012136 DNA binding site [nucleotide binding] 272943012137 sequence specific DNA binding site [nucleotide binding]; other site 272943012138 putative cAMP binding site [chemical binding]; other site 272943012139 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943012140 DNA-binding site [nucleotide binding]; DNA binding site 272943012141 RNA-binding motif; other site 272943012142 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272943012143 DNA-binding site [nucleotide binding]; DNA binding site 272943012144 RNA-binding motif; other site 272943012145 Protein of unknown function (DUF982); Region: DUF982; pfam06169 272943012146 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272943012147 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272943012148 active site 272943012149 Int/Topo IB signature motif; other site 272943012150 catalytic residues [active] 272943012151 DNA binding site [nucleotide binding] 272943012152 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272943012153 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 272943012154 tandem repeat interface [polypeptide binding]; other site 272943012155 oligomer interface [polypeptide binding]; other site 272943012156 active site residues [active] 272943012157 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272943012158 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272943012159 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943012160 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 272943012161 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 272943012162 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 272943012163 Ligand Binding Site [chemical binding]; other site 272943012164 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 272943012165 helix-hairpin-helix signature motif; other site 272943012166 substrate binding pocket [chemical binding]; other site 272943012167 active site 272943012168 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 272943012169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272943012170 Zn2+ binding site [ion binding]; other site 272943012171 Mg2+ binding site [ion binding]; other site 272943012172 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272943012173 AAA domain; Region: AAA_17; cl19128 272943012174 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272943012175 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 272943012176 tandem repeat interface [polypeptide binding]; other site 272943012177 oligomer interface [polypeptide binding]; other site 272943012178 active site residues [active] 272943012179 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 272943012180 Phage capsid family; Region: Phage_capsid; pfam05065 272943012181 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 272943012182 putative active site [active] 272943012183 catalytic residue [active] 272943012184 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 272943012185 dimer interface [polypeptide binding]; other site 272943012186 NADP binding site [chemical binding]; other site 272943012187 catalytic residues [active] 272943012188 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 272943012189 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 272943012190 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 272943012191 active site 272943012192 catalytic triad [active] 272943012193 dimer interface [polypeptide binding]; other site 272943012194 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272943012195 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 272943012196 DctM-like transporters; Region: DctM; pfam06808 272943012197 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272943012198 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272943012199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943012200 DNA-binding site [nucleotide binding]; DNA binding site 272943012201 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272943012202 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943012203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943012204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943012205 DNA binding residues [nucleotide binding] 272943012206 dimerization interface [polypeptide binding]; other site 272943012207 Domain of unknown function DUF11; Region: DUF11; pfam01345 272943012208 Domain of unknown function DUF11; Region: DUF11; cl17728 272943012209 Domain of unknown function DUF11; Region: DUF11; cl17728 272943012210 Domain of unknown function DUF11; Region: DUF11; pfam01345 272943012211 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272943012212 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272943012213 Putative L-xylulose-5-phosphate 3-epimerase [Carbohydrate transport and metabolism]; Region: SgaU; COG3623 272943012214 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272943012215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272943012216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012217 dimer interface [polypeptide binding]; other site 272943012218 conserved gate region; other site 272943012219 putative PBP binding loops; other site 272943012220 ABC-ATPase subunit interface; other site 272943012221 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272943012222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012223 dimer interface [polypeptide binding]; other site 272943012224 conserved gate region; other site 272943012225 putative PBP binding loops; other site 272943012226 ABC-ATPase subunit interface; other site 272943012227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272943012228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272943012229 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272943012230 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272943012231 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943012232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272943012233 DNA-binding site [nucleotide binding]; DNA binding site 272943012234 FCD domain; Region: FCD; pfam07729 272943012235 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272943012236 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272943012237 Walker A/P-loop; other site 272943012238 ATP binding site [chemical binding]; other site 272943012239 Q-loop/lid; other site 272943012240 ABC transporter signature motif; other site 272943012241 Walker B; other site 272943012242 D-loop; other site 272943012243 H-loop/switch region; other site 272943012244 TOBE domain; Region: TOBE_2; pfam08402 272943012245 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 272943012246 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 272943012247 FAD binding pocket [chemical binding]; other site 272943012248 FAD binding motif [chemical binding]; other site 272943012249 phosphate binding motif [ion binding]; other site 272943012250 NAD binding pocket [chemical binding]; other site 272943012251 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272943012252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272943012253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272943012254 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 272943012255 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 272943012256 putative active site [active] 272943012257 putative FMN binding site [chemical binding]; other site 272943012258 putative substrate binding site [chemical binding]; other site 272943012259 putative catalytic residue [active] 272943012260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943012261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272943012262 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272943012263 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272943012264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272943012265 DNA binding residues [nucleotide binding] 272943012266 dimerization interface [polypeptide binding]; other site 272943012267 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 272943012268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272943012269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272943012270 DNA binding site [nucleotide binding] 272943012271 domain linker motif; other site 272943012272 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 272943012273 putative dimerization interface [polypeptide binding]; other site 272943012274 putative ligand binding site [chemical binding]; other site 272943012275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272943012276 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272943012277 ligand binding site [chemical binding]; other site 272943012278 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943012279 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943012280 Walker A/P-loop; other site 272943012281 ATP binding site [chemical binding]; other site 272943012282 Q-loop/lid; other site 272943012283 ABC transporter signature motif; other site 272943012284 Walker B; other site 272943012285 D-loop; other site 272943012286 H-loop/switch region; other site 272943012287 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943012288 TM-ABC transporter signature motif; other site 272943012289 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 272943012290 active site 272943012291 substrate binding pocket [chemical binding]; other site 272943012292 homodimer interaction site [polypeptide binding]; other site 272943012293 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272943012294 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272943012295 substrate binding site [chemical binding]; other site 272943012296 dimer interface [polypeptide binding]; other site 272943012297 ATP binding site [chemical binding]; other site 272943012298 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 272943012299 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 272943012300 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 272943012301 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 272943012302 metal binding site [ion binding]; metal-binding site 272943012303 dimer interface [polypeptide binding]; other site 272943012304 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 272943012305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943012306 Walker A/P-loop; other site 272943012307 ATP binding site [chemical binding]; other site 272943012308 Q-loop/lid; other site 272943012309 ABC transporter signature motif; other site 272943012310 Walker B; other site 272943012311 D-loop; other site 272943012312 H-loop/switch region; other site 272943012313 TOBE-like domain; Region: TOBE_3; pfam12857 272943012314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272943012315 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272943012316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012317 dimer interface [polypeptide binding]; other site 272943012318 conserved gate region; other site 272943012319 putative PBP binding loops; other site 272943012320 ABC-ATPase subunit interface; other site 272943012321 sulfate transport protein; Provisional; Region: cysT; CHL00187 272943012322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012323 dimer interface [polypeptide binding]; other site 272943012324 conserved gate region; other site 272943012325 putative PBP binding loops; other site 272943012326 ABC-ATPase subunit interface; other site 272943012327 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272943012328 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272943012329 DNA binding site [nucleotide binding] 272943012330 domain linker motif; other site 272943012331 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 272943012332 dimerization interface [polypeptide binding]; other site 272943012333 ligand binding site [chemical binding]; other site 272943012334 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 272943012335 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 272943012336 putative ligand binding site [chemical binding]; other site 272943012337 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272943012338 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943012339 Walker A/P-loop; other site 272943012340 ATP binding site [chemical binding]; other site 272943012341 Q-loop/lid; other site 272943012342 ABC transporter signature motif; other site 272943012343 Walker B; other site 272943012344 D-loop; other site 272943012345 H-loop/switch region; other site 272943012346 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943012347 TM-ABC transporter signature motif; other site 272943012348 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272943012349 classical (c) SDRs; Region: SDR_c; cd05233 272943012350 NAD(P) binding site [chemical binding]; other site 272943012351 active site 272943012352 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 272943012353 N- and C-terminal domain interface [polypeptide binding]; other site 272943012354 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 272943012355 active site 272943012356 MgATP binding site [chemical binding]; other site 272943012357 catalytic site [active] 272943012358 metal binding site [ion binding]; metal-binding site 272943012359 carbohydrate binding site [chemical binding]; other site 272943012360 putative homodimer interface [polypeptide binding]; other site 272943012361 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272943012362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272943012363 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272943012364 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272943012365 ligand binding site [chemical binding]; other site 272943012366 flexible hinge region; other site 272943012367 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272943012368 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272943012369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272943012370 dimerization interface [polypeptide binding]; other site 272943012371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272943012372 dimer interface [polypeptide binding]; other site 272943012373 putative CheW interface [polypeptide binding]; other site 272943012374 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 272943012375 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 272943012376 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 272943012377 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 272943012378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943012379 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 272943012380 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 272943012381 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272943012382 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 272943012383 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 272943012384 selenophosphate synthetase; Provisional; Region: PRK00943 272943012385 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 272943012386 dimerization interface [polypeptide binding]; other site 272943012387 putative ATP binding site [chemical binding]; other site 272943012388 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 272943012389 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272943012390 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272943012391 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 272943012392 Uncharacterized conserved protein [Function unknown]; Region: COG5663 272943012393 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272943012394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272943012395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272943012396 active site 272943012397 Uncharacterized conserved protein [Function unknown]; Region: COG5663 272943012398 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272943012399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272943012400 Histidine kinase; Region: HisKA_2; pfam07568 272943012401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272943012402 ATP binding site [chemical binding]; other site 272943012403 Mg2+ binding site [ion binding]; other site 272943012404 G-X-G motif; other site 272943012405 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272943012406 G1 box; other site 272943012407 GTP/Mg2+ binding site [chemical binding]; other site 272943012408 G2 box; other site 272943012409 Switch I region; other site 272943012410 G3 box; other site 272943012411 Switch II region; other site 272943012412 G4 box; other site 272943012413 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272943012414 G1 box; other site 272943012415 GTP/Mg2+ binding site [chemical binding]; other site 272943012416 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272943012417 G3 box; other site 272943012418 Switch II region; other site 272943012419 GTP/Mg2+ binding site [chemical binding]; other site 272943012420 G4 box; other site 272943012421 G5 box; other site 272943012422 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272943012423 putative S-transferase; Provisional; Region: PRK11752 272943012424 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272943012425 C-terminal domain interface [polypeptide binding]; other site 272943012426 GSH binding site (G-site) [chemical binding]; other site 272943012427 dimer interface [polypeptide binding]; other site 272943012428 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 272943012429 dimer interface [polypeptide binding]; other site 272943012430 N-terminal domain interface [polypeptide binding]; other site 272943012431 active site 272943012432 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272943012433 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272943012434 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272943012435 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272943012436 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272943012437 ligand binding site [chemical binding]; other site 272943012438 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272943012439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272943012440 Walker A/P-loop; other site 272943012441 ATP binding site [chemical binding]; other site 272943012442 Q-loop/lid; other site 272943012443 ABC transporter signature motif; other site 272943012444 Walker B; other site 272943012445 D-loop; other site 272943012446 H-loop/switch region; other site 272943012447 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272943012448 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943012449 TM-ABC transporter signature motif; other site 272943012450 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272943012451 TM-ABC transporter signature motif; other site 272943012452 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 272943012453 active site 272943012454 catalytic residues [active] 272943012455 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272943012456 substrate binding site [chemical binding]; other site 272943012457 dimer interface [polypeptide binding]; other site 272943012458 ATP binding site [chemical binding]; other site 272943012459 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272943012460 intersubunit interface [polypeptide binding]; other site 272943012461 active site 272943012462 catalytic residue [active] 272943012463 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272943012464 NAD(P) binding site [chemical binding]; other site 272943012465 catalytic residues [active] 272943012466 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272943012467 NAD(P) binding site [chemical binding]; other site 272943012468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272943012469 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272943012470 substrate binding pocket [chemical binding]; other site 272943012471 membrane-bound complex binding site; other site 272943012472 hinge residues; other site 272943012473 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 272943012474 oligomer interface [polypeptide binding]; other site 272943012475 putative active site [active] 272943012476 Mn binding site [ion binding]; other site 272943012477 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272943012478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012479 dimer interface [polypeptide binding]; other site 272943012480 conserved gate region; other site 272943012481 putative PBP binding loops; other site 272943012482 ABC-ATPase subunit interface; other site 272943012483 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272943012484 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272943012485 Walker A/P-loop; other site 272943012486 ATP binding site [chemical binding]; other site 272943012487 Q-loop/lid; other site 272943012488 ABC transporter signature motif; other site 272943012489 Walker B; other site 272943012490 D-loop; other site 272943012491 H-loop/switch region; other site 272943012492 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 272943012493 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272943012494 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272943012495 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272943012496 active site 272943012497 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272943012498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943012499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943012500 dimerization interface [polypeptide binding]; other site 272943012501 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 272943012502 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 272943012503 RES domain; Region: RES; pfam08808 272943012504 AAA domain; Region: AAA_22; pfam13401 272943012505 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 272943012506 AAA ATPase domain; Region: AAA_15; pfam13175 272943012507 AAA domain; Region: AAA_23; pfam13476 272943012508 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272943012509 active site 272943012510 Walker A/P-loop; other site 272943012511 ATP binding site [chemical binding]; other site 272943012512 AAA domain; Region: AAA_21; pfam13304 272943012513 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 272943012514 putative active site [active] 272943012515 putative metal-binding site [ion binding]; other site 272943012516 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272943012517 cofactor binding site; other site 272943012518 DNA binding site [nucleotide binding] 272943012519 substrate interaction site [chemical binding]; other site 272943012520 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 272943012521 additional DNA contacts [nucleotide binding]; other site 272943012522 mismatch recognition site; other site 272943012523 active site 272943012524 zinc binding site [ion binding]; other site 272943012525 DNA intercalation site [nucleotide binding]; other site 272943012526 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272943012527 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 272943012528 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272943012529 Phage-related tail protein [Function unknown]; Region: COG5283 272943012530 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 272943012531 Phage tail protein; Region: Phage_tail_3; pfam08813 272943012532 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 272943012533 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 272943012534 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 272943012535 tandem repeat interface [polypeptide binding]; other site 272943012536 oligomer interface [polypeptide binding]; other site 272943012537 active site residues [active] 272943012538 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 272943012539 Phage terminase large subunit (GpA); Region: Terminase_GpA; cl19377 272943012540 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 272943012541 ABC1 family; Region: ABC1; cl17513 272943012542 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 272943012543 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 272943012544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272943012545 non-specific DNA binding site [nucleotide binding]; other site 272943012546 salt bridge; other site 272943012547 sequence-specific DNA binding site [nucleotide binding]; other site 272943012548 Predicted transcriptional regulator [Transcription]; Region: COG2932 272943012549 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 272943012550 Catalytic site [active] 272943012551 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 272943012552 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 272943012553 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 272943012554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272943012555 active site 272943012556 DNA binding site [nucleotide binding] 272943012557 Int/Topo IB signature motif; other site 272943012558 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 272943012559 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272943012560 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272943012561 inhibitor-cofactor binding pocket; inhibition site 272943012562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272943012563 catalytic residue [active] 272943012564 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943012565 Ligand Binding Site [chemical binding]; other site 272943012566 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 272943012567 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272943012568 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272943012569 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272943012570 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272943012571 putative active site [active] 272943012572 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 272943012573 active site 272943012574 catalytic site [active] 272943012575 Zn binding site [ion binding]; other site 272943012576 tetramer interface [polypeptide binding]; other site 272943012577 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272943012578 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943012579 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272943012580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 272943012581 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 272943012582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 272943012583 ParB-like nuclease domain; Region: ParBc; cl02129 272943012584 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 272943012585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943012586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272943012587 P-loop; other site 272943012588 Magnesium ion binding site [ion binding]; other site 272943012589 Initiator Replication protein; Region: Rep_3; pfam01051 272943012590 Chain length determinant protein; Region: Wzz; cl19730 272943012591 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 272943012592 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272943012593 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272943012594 Walker A/P-loop; other site 272943012595 ATP binding site [chemical binding]; other site 272943012596 Q-loop/lid; other site 272943012597 ABC transporter signature motif; other site 272943012598 Walker B; other site 272943012599 D-loop; other site 272943012600 H-loop/switch region; other site 272943012601 ParB-like nuclease domain; Region: ParBc; pfam02195 272943012602 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 272943012603 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943012604 P-loop; other site 272943012605 Magnesium ion binding site [ion binding]; other site 272943012606 Replication initiator protein A; Region: RPA; pfam10134 272943012607 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272943012608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272943012609 active site 272943012610 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272943012611 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272943012612 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272943012613 NAD binding site [chemical binding]; other site 272943012614 substrate binding site [chemical binding]; other site 272943012615 homodimer interface [polypeptide binding]; other site 272943012616 active site 272943012617 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272943012618 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272943012619 NADP binding site [chemical binding]; other site 272943012620 active site 272943012621 putative substrate binding site [chemical binding]; other site 272943012622 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272943012623 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272943012624 substrate binding site; other site 272943012625 tetramer interface; other site 272943012626 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272943012627 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 272943012628 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272943012629 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 272943012630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272943012631 S-adenosylmethionine binding site [chemical binding]; other site 272943012632 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272943012633 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272943012634 HlyD family secretion protein; Region: HlyD_3; pfam13437 272943012635 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272943012636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272943012637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943012638 Walker A/P-loop; other site 272943012639 ATP binding site [chemical binding]; other site 272943012640 Q-loop/lid; other site 272943012641 ABC transporter signature motif; other site 272943012642 Walker B; other site 272943012643 D-loop; other site 272943012644 H-loop/switch region; other site 272943012645 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 272943012646 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 272943012647 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272943012648 Calx-beta domain; Region: Calx-beta; cl02522 272943012649 Calx-beta domain; Region: Calx-beta; cl02522 272943012650 Calx-beta domain; Region: Calx-beta; cl02522 272943012651 Calx-beta domain; Region: Calx-beta; cl02522 272943012652 Calx-beta domain; Region: Calx-beta; cl02522 272943012653 Calx-beta domain; Region: Calx-beta; cl02522 272943012654 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943012655 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 272943012656 UPF0126 domain; Region: UPF0126; pfam03458 272943012657 Predicted membrane protein [Function unknown]; Region: COG2860 272943012658 UPF0126 domain; Region: UPF0126; pfam03458 272943012659 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272943012660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272943012661 dimerization interface [polypeptide binding]; other site 272943012662 putative DNA binding site [nucleotide binding]; other site 272943012663 putative Zn2+ binding site [ion binding]; other site 272943012664 AsnC family; Region: AsnC_trans_reg; pfam01037 272943012665 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 272943012666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943012667 Walker A/P-loop; other site 272943012668 ATP binding site [chemical binding]; other site 272943012669 Q-loop/lid; other site 272943012670 ABC transporter signature motif; other site 272943012671 Walker B; other site 272943012672 D-loop; other site 272943012673 H-loop/switch region; other site 272943012674 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272943012675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012676 dimer interface [polypeptide binding]; other site 272943012677 conserved gate region; other site 272943012678 putative PBP binding loops; other site 272943012679 ABC-ATPase subunit interface; other site 272943012680 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272943012681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012682 dimer interface [polypeptide binding]; other site 272943012683 conserved gate region; other site 272943012684 putative PBP binding loops; other site 272943012685 ABC-ATPase subunit interface; other site 272943012686 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 272943012687 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 272943012688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943012689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272943012690 dimerization interface [polypeptide binding]; other site 272943012691 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 272943012692 Predicted transcriptional regulator [Transcription]; Region: COG1959 272943012693 Rrf2 family protein; Region: rrf2_super; TIGR00738 272943012694 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272943012695 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 272943012696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272943012697 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 272943012698 Walker A/P-loop; other site 272943012699 ATP binding site [chemical binding]; other site 272943012700 Q-loop/lid; other site 272943012701 ABC transporter signature motif; other site 272943012702 Walker B; other site 272943012703 D-loop; other site 272943012704 H-loop/switch region; other site 272943012705 TOBE domain; Region: TOBE; pfam03459 272943012706 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272943012707 TOBE domain; Region: TOBE; cl01440 272943012708 molybdenum transport protein ModD; Provisional; Region: PRK06096 272943012709 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 272943012710 dimerization interface [polypeptide binding]; other site 272943012711 active site 272943012712 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 272943012713 ModE molybdate transport repressor domain; Region: ModE_repress; TIGR00637 272943012714 molybdenum-pterin binding domain; Region: Mop; TIGR00638 272943012715 TOBE domain; Region: TOBE; cl01440 272943012716 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943012717 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 272943012718 active site 272943012719 catalytic residues [active] 272943012720 flagellin; Reviewed; Region: PRK12687 272943012721 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272943012722 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272943012723 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 272943012724 Flagellar protein FlbT; Region: FlbT; pfam07378 272943012725 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 272943012726 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 272943012727 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272943012728 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943012729 Walker A/P-loop; other site 272943012730 ATP binding site [chemical binding]; other site 272943012731 Q-loop/lid; other site 272943012732 ABC transporter signature motif; other site 272943012733 Walker B; other site 272943012734 D-loop; other site 272943012735 H-loop/switch region; other site 272943012736 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943012737 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272943012738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272943012739 Walker A/P-loop; other site 272943012740 ATP binding site [chemical binding]; other site 272943012741 Q-loop/lid; other site 272943012742 ABC transporter signature motif; other site 272943012743 Walker B; other site 272943012744 D-loop; other site 272943012745 H-loop/switch region; other site 272943012746 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272943012747 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272943012748 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 272943012749 active site pocket [active] 272943012750 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 272943012751 Uncharacterized conserved protein [Function unknown]; Region: COG5476 272943012752 MlrC C-terminus; Region: MlrC_C; pfam07171 272943012753 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 272943012754 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 272943012755 putative active site [active] 272943012756 Zn binding site [ion binding]; other site 272943012757 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272943012758 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 272943012759 active site pocket [active] 272943012760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943012761 classical (c) SDRs; Region: SDR_c; cd05233 272943012762 NAD(P) binding site [chemical binding]; other site 272943012763 active site 272943012764 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272943012765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943012766 NAD(P) binding site [chemical binding]; other site 272943012767 active site 272943012768 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272943012769 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272943012770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012771 dimer interface [polypeptide binding]; other site 272943012772 conserved gate region; other site 272943012773 putative PBP binding loops; other site 272943012774 ABC-ATPase subunit interface; other site 272943012775 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272943012776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272943012777 dimer interface [polypeptide binding]; other site 272943012778 conserved gate region; other site 272943012779 putative PBP binding loops; other site 272943012780 ABC-ATPase subunit interface; other site 272943012781 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272943012782 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 272943012783 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272943012784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272943012785 DNA-binding site [nucleotide binding]; DNA binding site 272943012786 FCD domain; Region: FCD; pfam07729 272943012787 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272943012788 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272943012789 Protein of unknown function (DUF497); Region: DUF497; pfam04365 272943012790 Restriction endonuclease; Region: Mrr_cat; pfam04471 272943012791 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 272943012792 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272943012793 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272943012794 catalytic residues [active] 272943012795 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 272943012796 multimer interface [polypeptide binding]; other site 272943012797 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 272943012798 Walker A motif; other site 272943012799 ATP binding site [chemical binding]; other site 272943012800 Walker B motif; other site 272943012801 TrwC relaxase; Region: TrwC; pfam08751 272943012802 AAA domain; Region: AAA_30; pfam13604 272943012803 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 272943012804 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272943012805 VirC1 protein; Region: VirC1; cl17401 272943012806 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272943012807 P-loop; other site 272943012808 Magnesium ion binding site [ion binding]; other site 272943012809 Domain of unknown function (DUF932); Region: DUF932; pfam06067 272943012810 Replication protein C N-terminal domain; Region: RP-C; pfam03428 272943012811 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 272943012812 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 272943012813 core domain interface [polypeptide binding]; other site 272943012814 delta subunit interface [polypeptide binding]; other site 272943012815 epsilon subunit interface [polypeptide binding]; other site 272943012816 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 272943012817 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272943012818 Walker A motif; other site 272943012819 ATP binding site [chemical binding]; other site 272943012820 Walker B motif; other site 272943012821 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272943012822 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 272943012823 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272943012824 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 272943012825 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 272943012826 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 272943012827 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 272943012828 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272943012829 gamma subunit interface [polypeptide binding]; other site 272943012830 epsilon subunit interface [polypeptide binding]; other site 272943012831 LBP interface [polypeptide binding]; other site 272943012832 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 272943012833 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272943012834 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272943012835 alpha subunit interaction interface [polypeptide binding]; other site 272943012836 Walker A motif; other site 272943012837 ATP binding site [chemical binding]; other site 272943012838 Walker B motif; other site 272943012839 inhibitor binding site; inhibition site 272943012840 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272943012841 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272943012842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272943012843 NAD(P) binding site [chemical binding]; other site 272943012844 active site 272943012845 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 272943012846 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272943012847 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 272943012848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 272943012849 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 272943012850 Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); Region: ClassIIa_HDAC_Gln-rich-N; cl13614 272943012851 tetramer interface [polypeptide binding]; other site 272943012852 dimer interface A, C [polypeptide binding]; other site 272943012853 dimer interface A, D [polypeptide binding]; other site 272943012854 dimer interface A, B [polypeptide binding]; other site 272943012855 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 272943012856 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 272943012857 putative ligand binding site [chemical binding]; other site 272943012858 putative catalytic site [active] 272943012859 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272943012860 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 272943012861 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272943012862 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272943012863 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272943012864 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272943012865 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272943012866 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272943012867 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272943012868 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943012869 Ligand Binding Site [chemical binding]; other site 272943012870 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272943012871 Ligand Binding Site [chemical binding]; other site 272943012872 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272943012873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272943012874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272943012875 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 272943012876 putative substrate binding pocket [chemical binding]; other site 272943012877 putative dimerization interface [polypeptide binding]; other site 272943012878 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 272943012879 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272943012880 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 272943012881 DNA binding residues [nucleotide binding] 272943012882 putative dimer interface [polypeptide binding]; other site 272943012883 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272943012884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272943012885 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 272943012886 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272943012887 Cupin domain; Region: Cupin_2; cl17218 272943012888 Helix-turn-helix domain; Region: HTH_18; pfam12833 272943012889 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272943012890 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272943012891 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272943012892 Walker A/P-loop; other site 272943012893 ATP binding site [chemical binding]; other site 272943012894 Q-loop/lid; other site 272943012895 ABC transporter signature motif; other site 272943012896 Walker B; other site 272943012897 D-loop; other site 272943012898 H-loop/switch region; other site 272943012899 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272943012900 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943012901 ABC-ATPase subunit interface; other site 272943012902 dimer interface [polypeptide binding]; other site 272943012903 putative PBP binding regions; other site 272943012904 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272943012905 dimer interface [polypeptide binding]; other site 272943012906 putative PBP binding regions; other site 272943012907 ABC-ATPase subunit interface; other site 272943012908 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272943012909 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272943012910 intersubunit interface [polypeptide binding]; other site 272943012911 Secretin and TonB N terminus short domain; Region: STN; smart00965 272943012912 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 272943012913 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272943012914 N-terminal plug; other site 272943012915 ligand-binding site [chemical binding]; other site 272943012916 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 272943012917 FecR protein; Region: FecR; pfam04773 272943012918 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 272943012919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272943012920 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272943012921 DNA binding residues [nucleotide binding] 272943012922 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272943012923 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 272943012924 DNA binding residues [nucleotide binding] 272943012925 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 272943012926 dimer interface [polypeptide binding]; other site 272943012927 putative metal binding site [ion binding]; other site 272943012928 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272943012929 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272943012930 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 272943012931 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 272943012932 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 272943012933 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 272943012934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272943012935 Winged helix-turn helix; Region: HTH_29; pfam13551 272943012936 Helix-turn-helix domain; Region: HTH_28; pfam13518 272943012937 Homeodomain-like domain; Region: HTH_32; pfam13565 272943012938 Integrase core domain; Region: rve; pfam00665