-- dump date   	20140620_023333
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
859656000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
859656000002	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
859656000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656000004	Walker A motif; other site
859656000005	ATP binding site [chemical binding]; other site
859656000006	Walker B motif; other site
859656000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859656000008	arginine finger; other site
859656000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
859656000010	DnaA box-binding interface [nucleotide binding]; other site
859656000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
859656000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
859656000013	putative DNA binding surface [nucleotide binding]; other site
859656000014	dimer interface [polypeptide binding]; other site
859656000015	beta-clamp/clamp loader binding surface; other site
859656000016	beta-clamp/translesion DNA polymerase binding surface; other site
859656000017	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
859656000018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000019	ATP binding site [chemical binding]; other site
859656000020	Mg2+ binding site [ion binding]; other site
859656000021	G-X-G motif; other site
859656000022	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
859656000023	anchoring element; other site
859656000024	dimer interface [polypeptide binding]; other site
859656000025	ATP binding site [chemical binding]; other site
859656000026	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
859656000027	active site
859656000028	putative metal-binding site [ion binding]; other site
859656000029	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
859656000030	Transposase; Region: HTH_Tnp_1; pfam01527
859656000031	HTH-like domain; Region: HTH_21; pfam13276
859656000032	Integrase core domain; Region: rve; pfam00665
859656000033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859656000034	Integrase core domain; Region: rve_3; pfam13683
859656000035	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
859656000036	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
859656000037	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
859656000038	cofactor binding site; other site
859656000039	DNA binding site [nucleotide binding]
859656000040	substrate interaction site [chemical binding]; other site
859656000041	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
859656000042	AAA-like domain; Region: AAA_10; pfam12846
859656000043	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859656000044	DNA-binding interface [nucleotide binding]; DNA binding site
859656000045	putative transposase OrfB; Reviewed; Region: PHA02517
859656000046	HTH-like domain; Region: HTH_21; pfam13276
859656000047	Integrase core domain; Region: rve; pfam00665
859656000048	Integrase core domain; Region: rve_3; pfam13683
859656000049	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859656000050	Uncharacterized conserved protein [Function unknown]; Region: COG5435
859656000051	PAAR motif; Region: PAAR_motif; pfam05488
859656000052	Predicted transcriptional regulators [Transcription]; Region: COG1695
859656000053	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
859656000054	HD domain; Region: HD_4; pfam13328
859656000055	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
859656000056	homodimer interface [polypeptide binding]; other site
859656000057	chemical substrate binding site [chemical binding]; other site
859656000058	oligomer interface [polypeptide binding]; other site
859656000059	metal binding site [ion binding]; metal-binding site
859656000060	Restriction endonuclease; Region: Mrr_cat; pfam04471
859656000061	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
859656000062	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859656000063	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656000064	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656000065	Restriction endonuclease; Region: Mrr_cat; pfam04471
859656000066	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
859656000067	Evidence 4 : Homologs of previously reported genes of unknown function
859656000068	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656000069	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656000070	dimer interface [polypeptide binding]; other site
859656000071	putative CheW interface [polypeptide binding]; other site
859656000072	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859656000073	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859656000074	Bacterial transcriptional regulator; Region: IclR; pfam01614
859656000075	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656000076	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656000077	substrate binding pocket [chemical binding]; other site
859656000078	membrane-bound complex binding site; other site
859656000079	hinge residues; other site
859656000080	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656000081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656000082	dimer interface [polypeptide binding]; other site
859656000083	conserved gate region; other site
859656000084	putative PBP binding loops; other site
859656000085	ABC-ATPase subunit interface; other site
859656000086	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859656000087	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859656000088	Walker A/P-loop; other site
859656000089	ATP binding site [chemical binding]; other site
859656000090	Q-loop/lid; other site
859656000091	ABC transporter signature motif; other site
859656000092	Walker B; other site
859656000093	D-loop; other site
859656000094	H-loop/switch region; other site
859656000095	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859656000096	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859656000097	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
859656000098	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
859656000099	NADH(P)-binding; Region: NAD_binding_10; pfam13460
859656000100	putative NAD(P) binding site [chemical binding]; other site
859656000101	active site
859656000102	DoxX-like family; Region: DoxX_3; pfam13781
859656000103	Predicted transcriptional regulators [Transcription]; Region: COG1510
859656000104	MarR family; Region: MarR_2; pfam12802
859656000105	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656000106	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
859656000107	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859656000108	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859656000109	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859656000110	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656000111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000112	active site
859656000113	phosphorylation site [posttranslational modification]
859656000114	intermolecular recognition site; other site
859656000115	dimerization interface [polypeptide binding]; other site
859656000116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656000117	DNA binding site [nucleotide binding]
859656000118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656000119	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656000120	dimer interface [polypeptide binding]; other site
859656000121	phosphorylation site [posttranslational modification]
859656000122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000123	ATP binding site [chemical binding]; other site
859656000124	Mg2+ binding site [ion binding]; other site
859656000125	G-X-G motif; other site
859656000126	CAAX protease self-immunity; Region: Abi; pfam02517
859656000127	hypothetical protein; Validated; Region: PRK09169
859656000128	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859656000129	metal binding triad [ion binding]; metal-binding site
859656000130	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859656000131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656000132	putative substrate translocation pore; other site
859656000133	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
859656000134	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
859656000135	heme-binding site [chemical binding]; other site
859656000136	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
859656000137	FAD binding pocket [chemical binding]; other site
859656000138	FAD binding motif [chemical binding]; other site
859656000139	phosphate binding motif [ion binding]; other site
859656000140	beta-alpha-beta structure motif; other site
859656000141	NAD binding pocket [chemical binding]; other site
859656000142	Heme binding  pocket [chemical binding]; other site
859656000143	Transcriptional regulator; Region: Rrf2; cl17282
859656000144	Rrf2 family protein; Region: rrf2_super; TIGR00738
859656000145	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
859656000146	Methyltransferase domain; Region: Methyltransf_26; pfam13659
859656000147	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
859656000148	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
859656000149	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859656000150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656000151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656000152	dimer interface [polypeptide binding]; other site
859656000153	phosphorylation site [posttranslational modification]
859656000154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000155	ATP binding site [chemical binding]; other site
859656000156	Mg2+ binding site [ion binding]; other site
859656000157	G-X-G motif; other site
859656000158	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
859656000159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000160	active site
859656000161	phosphorylation site [posttranslational modification]
859656000162	intermolecular recognition site; other site
859656000163	dimerization interface [polypeptide binding]; other site
859656000164	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656000165	DNA binding site [nucleotide binding]
859656000166	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859656000167	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
859656000168	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656000169	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656000170	eyelet of channel; other site
859656000171	trimer interface [polypeptide binding]; other site
859656000172	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656000173	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656000174	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656000175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000176	active site
859656000177	phosphorylation site [posttranslational modification]
859656000178	intermolecular recognition site; other site
859656000179	dimerization interface [polypeptide binding]; other site
859656000180	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656000181	DNA binding residues [nucleotide binding]
859656000182	dimerization interface [polypeptide binding]; other site
859656000183	Response regulator receiver domain; Region: Response_reg; pfam00072
859656000184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000185	active site
859656000186	phosphorylation site [posttranslational modification]
859656000187	intermolecular recognition site; other site
859656000188	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656000189	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
859656000190	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
859656000191	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
859656000192	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
859656000193	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
859656000194	Ligand Binding Site [chemical binding]; other site
859656000195	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
859656000196	GAF domain; Region: GAF_3; pfam13492
859656000197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656000198	dimer interface [polypeptide binding]; other site
859656000199	phosphorylation site [posttranslational modification]
859656000200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000201	ATP binding site [chemical binding]; other site
859656000202	Mg2+ binding site [ion binding]; other site
859656000203	G-X-G motif; other site
859656000204	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
859656000205	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
859656000206	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859656000207	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
859656000208	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
859656000209	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
859656000210	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656000211	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656000212	DNA binding residues [nucleotide binding]
859656000213	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859656000214	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859656000215	Walker A/P-loop; other site
859656000216	ATP binding site [chemical binding]; other site
859656000217	Q-loop/lid; other site
859656000218	ABC transporter signature motif; other site
859656000219	Walker B; other site
859656000220	D-loop; other site
859656000221	H-loop/switch region; other site
859656000222	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
859656000223	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
859656000224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656000225	dimer interface [polypeptide binding]; other site
859656000226	conserved gate region; other site
859656000227	putative PBP binding loops; other site
859656000228	ABC-ATPase subunit interface; other site
859656000229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656000230	dimer interface [polypeptide binding]; other site
859656000231	conserved gate region; other site
859656000232	putative PBP binding loops; other site
859656000233	ABC-ATPase subunit interface; other site
859656000234	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
859656000235	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
859656000236	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859656000237	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859656000238	cell division topological specificity factor MinE; Provisional; Region: PRK13989
859656000239	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
859656000240	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
859656000241	Switch I; other site
859656000242	Switch II; other site
859656000243	septum formation inhibitor; Reviewed; Region: PRK01973
859656000244	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
859656000245	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
859656000246	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2172762, 3005231; Product type e : enzyme
859656000247	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
859656000248	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859656000249	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
859656000250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4322
859656000251	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859656000252	IHF dimer interface [polypeptide binding]; other site
859656000253	IHF - DNA interface [nucleotide binding]; other site
859656000254	Proteins containing SET domain [General function prediction only]; Region: COG2940
859656000255	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
859656000256	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859656000257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656000258	dimer interface [polypeptide binding]; other site
859656000259	phosphorylation site [posttranslational modification]
859656000260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000261	ATP binding site [chemical binding]; other site
859656000262	Mg2+ binding site [ion binding]; other site
859656000263	G-X-G motif; other site
859656000264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656000265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000266	active site
859656000267	phosphorylation site [posttranslational modification]
859656000268	intermolecular recognition site; other site
859656000269	dimerization interface [polypeptide binding]; other site
859656000270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656000271	DNA binding site [nucleotide binding]
859656000272	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
859656000273	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
859656000274	aromatic arch; other site
859656000275	DCoH dimer interaction site [polypeptide binding]; other site
859656000276	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
859656000277	DCoH tetramer interaction site [polypeptide binding]; other site
859656000278	substrate binding site [chemical binding]; other site
859656000279	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
859656000280	cofactor binding site; other site
859656000281	metal binding site [ion binding]; metal-binding site
859656000282	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656000283	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
859656000284	AsnC family; Region: AsnC_trans_reg; pfam01037
859656000285	Predicted membrane protein [Function unknown]; Region: COG3714
859656000286	ornithine cyclodeaminase; Validated; Region: PRK07340
859656000287	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
859656000288	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
859656000289	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
859656000290	metal-binding site [ion binding]
859656000291	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
859656000292	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
859656000293	metal-binding site [ion binding]
859656000294	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859656000295	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656000296	motif II; other site
859656000297	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
859656000298	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
859656000299	DNA binding residues [nucleotide binding]
859656000300	dimer interface [polypeptide binding]; other site
859656000301	copper binding site [ion binding]; other site
859656000302	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
859656000303	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656000304	choline dehydrogenase; Validated; Region: PRK02106
859656000305	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859656000306	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859656000307	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656000308	Walker A/P-loop; other site
859656000309	ATP binding site [chemical binding]; other site
859656000310	Q-loop/lid; other site
859656000311	ABC transporter signature motif; other site
859656000312	Walker B; other site
859656000313	D-loop; other site
859656000314	H-loop/switch region; other site
859656000315	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859656000316	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656000317	Walker A/P-loop; other site
859656000318	ATP binding site [chemical binding]; other site
859656000319	Q-loop/lid; other site
859656000320	ABC transporter signature motif; other site
859656000321	Walker B; other site
859656000322	D-loop; other site
859656000323	H-loop/switch region; other site
859656000324	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656000325	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
859656000326	putative ligand binding site [chemical binding]; other site
859656000327	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656000328	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656000329	TM-ABC transporter signature motif; other site
859656000330	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656000331	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656000332	TM-ABC transporter signature motif; other site
859656000333	hypothetical protein; Provisional; Region: PRK10621
859656000334	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859656000335	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
859656000336	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656000337	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
859656000338	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859656000339	putative NAD(P) binding site [chemical binding]; other site
859656000340	putative active site [active]
859656000341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656000342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656000343	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656000344	dimerization interface [polypeptide binding]; other site
859656000345	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
859656000346	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656000347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656000348	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
859656000349	putative effector binding pocket; other site
859656000350	putative dimerization interface [polypeptide binding]; other site
859656000351	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
859656000352	putative NAD(P) binding site [chemical binding]; other site
859656000353	homodimer interface [polypeptide binding]; other site
859656000354	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656000355	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
859656000356	putative ligand binding site [chemical binding]; other site
859656000357	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
859656000358	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
859656000359	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
859656000360	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
859656000361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656000362	S-adenosylmethionine binding site [chemical binding]; other site
859656000363	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
859656000364	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859656000365	P-loop; other site
859656000366	Magnesium ion binding site [ion binding]; other site
859656000367	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859656000368	Magnesium ion binding site [ion binding]; other site
859656000369	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
859656000370	ParB-like nuclease domain; Region: ParB; smart00470
859656000371	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
859656000372	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
859656000373	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
859656000374	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
859656000375	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
859656000376	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
859656000377	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
859656000378	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
859656000379	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
859656000380	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
859656000381	beta subunit interaction interface [polypeptide binding]; other site
859656000382	Walker A motif; other site
859656000383	ATP binding site [chemical binding]; other site
859656000384	Walker B motif; other site
859656000385	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
859656000386	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
859656000387	core domain interface [polypeptide binding]; other site
859656000388	delta subunit interface [polypeptide binding]; other site
859656000389	epsilon subunit interface [polypeptide binding]; other site
859656000390	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
859656000391	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
859656000392	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
859656000393	alpha subunit interaction interface [polypeptide binding]; other site
859656000394	Walker A motif; other site
859656000395	ATP binding site [chemical binding]; other site
859656000396	Walker B motif; other site
859656000397	inhibitor binding site; inhibition site
859656000398	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
859656000399	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
859656000400	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
859656000401	gamma subunit interface [polypeptide binding]; other site
859656000402	epsilon subunit interface [polypeptide binding]; other site
859656000403	LBP interface [polypeptide binding]; other site
859656000404	FecR protein; Region: FecR; pfam04773
859656000405	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
859656000406	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
859656000407	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859656000408	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859656000409	Protein of unknown function (DUF3562); Region: DUF3562; pfam12085
859656000410	PBP superfamily domain; Region: PBP_like_2; cl17296
859656000411	glutathionine S-transferase; Provisional; Region: PRK10542
859656000412	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
859656000413	C-terminal domain interface [polypeptide binding]; other site
859656000414	GSH binding site (G-site) [chemical binding]; other site
859656000415	dimer interface [polypeptide binding]; other site
859656000416	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
859656000417	dimer interface [polypeptide binding]; other site
859656000418	N-terminal domain interface [polypeptide binding]; other site
859656000419	substrate binding pocket (H-site) [chemical binding]; other site
859656000420	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656000421	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656000422	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656000423	dimerization interface [polypeptide binding]; other site
859656000424	Cache domain; Region: Cache_1; pfam02743
859656000425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656000426	dimerization interface [polypeptide binding]; other site
859656000427	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656000428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656000429	dimer interface [polypeptide binding]; other site
859656000430	putative CheW interface [polypeptide binding]; other site
859656000431	Uncharacterized conserved protein [Function unknown]; Region: COG3791
859656000432	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
859656000433	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
859656000434	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
859656000435	substrate binding site [chemical binding]; other site
859656000436	active site
859656000437	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
859656000438	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656000439	ATP binding site [chemical binding]; other site
859656000440	putative Mg++ binding site [ion binding]; other site
859656000441	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
859656000442	Predicted transcriptional regulator [Transcription]; Region: COG3905
859656000443	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
859656000444	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
859656000445	Glutamate binding site [chemical binding]; other site
859656000446	NAD binding site [chemical binding]; other site
859656000447	catalytic residues [active]
859656000448	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859656000449	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656000450	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
859656000451	dimerization interface [polypeptide binding]; other site
859656000452	ligand binding site [chemical binding]; other site
859656000453	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
859656000454	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
859656000455	Predicted membrane protein [Function unknown]; Region: COG1297
859656000456	putative oligopeptide transporter, OPT family; Region: TIGR00733
859656000457	Ferritin-like; Region: Ferritin-like; pfam12902
859656000458	hypothetical protein; Provisional; Region: PRK05409
859656000459	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
859656000460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656000461	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656000462	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656000463	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656000464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859656000465	Uncharacterized conserved protein [Function unknown]; Region: COG4104
859656000466	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
859656000467	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
859656000468	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
859656000469	glycine dehydrogenase; Provisional; Region: PRK05367
859656000470	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
859656000471	tetramer interface [polypeptide binding]; other site
859656000472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656000473	catalytic residue [active]
859656000474	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
859656000475	tetramer interface [polypeptide binding]; other site
859656000476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656000477	catalytic residue [active]
859656000478	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
859656000479	lipoyl attachment site [posttranslational modification]; other site
859656000480	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
859656000481	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
859656000482	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
859656000483	Acyltransferase family; Region: Acyl_transf_3; pfam01757
859656000484	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
859656000485	Part of AAA domain; Region: AAA_19; pfam13245
859656000486	Family description; Region: UvrD_C_2; pfam13538
859656000487	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
859656000488	Inclusion body protein; Region: PixA; pfam12306
859656000489	Inclusion body protein; Region: PixA; pfam12306
859656000490	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
859656000491	Autoinducer binding domain; Region: Autoind_bind; pfam03472
859656000492	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656000493	DNA binding residues [nucleotide binding]
859656000494	dimerization interface [polypeptide binding]; other site
859656000495	Autoinducer synthetase; Region: Autoind_synth; cl17404
859656000496	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656000497	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859656000498	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
859656000499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656000500	FeS/SAM binding site; other site
859656000501	HemN C-terminal domain; Region: HemN_C; pfam06969
859656000502	pyruvate kinase; Provisional; Region: PRK06247
859656000503	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
859656000504	domain interfaces; other site
859656000505	active site
859656000506	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
859656000507	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
859656000508	MOFRL family; Region: MOFRL; pfam05161
859656000509	tartronate semialdehyde reductase; Provisional; Region: PRK15059
859656000510	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
859656000511	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
859656000512	glyoxylate carboligase; Provisional; Region: PRK11269
859656000513	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859656000514	PYR/PP interface [polypeptide binding]; other site
859656000515	dimer interface [polypeptide binding]; other site
859656000516	TPP binding site [chemical binding]; other site
859656000517	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859656000518	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
859656000519	TPP-binding site [chemical binding]; other site
859656000520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656000521	transcriptional activator TtdR; Provisional; Region: PRK09801
859656000522	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656000523	putative effector binding pocket; other site
859656000524	dimerization interface [polypeptide binding]; other site
859656000525	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
859656000526	Uncharacterized conserved protein [Function unknown]; Region: COG1739
859656000527	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
859656000528	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
859656000529	Transcriptional regulators [Transcription]; Region: FadR; COG2186
859656000530	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656000531	DNA-binding site [nucleotide binding]; DNA binding site
859656000532	FCD domain; Region: FCD; pfam07729
859656000533	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
859656000534	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859656000535	allantoicase; Provisional; Region: PRK13257
859656000536	Allantoicase repeat; Region: Allantoicase; pfam03561
859656000537	Allantoicase repeat; Region: Allantoicase; pfam03561
859656000538	ureidoglycolate hydrolase; Provisional; Region: PRK03606
859656000539	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
859656000540	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
859656000541	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
859656000542	putative metal binding site [ion binding]; other site
859656000543	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
859656000544	ArsC family; Region: ArsC; pfam03960
859656000545	catalytic residues [active]
859656000546	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
859656000547	active site
859656000548	substrate binding site [chemical binding]; other site
859656000549	catalytic site [active]
859656000550	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859656000551	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
859656000552	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
859656000553	Predicted methyltransferases [General function prediction only]; Region: COG0313
859656000554	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
859656000555	putative SAM binding site [chemical binding]; other site
859656000556	putative homodimer interface [polypeptide binding]; other site
859656000557	hypothetical protein; Provisional; Region: PRK14673
859656000558	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
859656000559	BON domain; Region: BON; pfam04972
859656000560	BON domain; Region: BON; cl02771
859656000561	Cytochrome c; Region: Cytochrom_C; cl11414
859656000562	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
859656000563	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
859656000564	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
859656000565	EamA-like transporter family; Region: EamA; pfam00892
859656000566	Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654
859656000567	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
859656000568	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
859656000569	Uncharacterized conserved protein [Function unknown]; Region: COG1416
859656000570	Cytochrome c; Region: Cytochrom_C; cl11414
859656000571	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859656000572	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656000573	catalytic residues [active]
859656000574	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
859656000575	active site
859656000576	metal binding site [ion binding]; metal-binding site
859656000577	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
859656000578	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
859656000579	Predicted ATPase [General function prediction only]; Region: COG5293
859656000580	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
859656000581	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
859656000582	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
859656000583	catalytic residues [active]
859656000584	catalytic nucleophile [active]
859656000585	Presynaptic Site I dimer interface [polypeptide binding]; other site
859656000586	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
859656000587	Synaptic Flat tetramer interface [polypeptide binding]; other site
859656000588	Synaptic Site I dimer interface [polypeptide binding]; other site
859656000589	DNA binding site [nucleotide binding]
859656000590	Recombinase; Region: Recombinase; pfam07508
859656000591	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
859656000592	Helix-turn-helix domain; Region: HTH_17; pfam12728
859656000593	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
859656000594	active site
859656000595	metal binding site [ion binding]; metal-binding site
859656000596	interdomain interaction site; other site
859656000597	AAA domain; Region: AAA_25; pfam13481
859656000598	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
859656000599	ATP binding site [chemical binding]; other site
859656000600	Walker B motif; other site
859656000601	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656000602	RHS Repeat; Region: RHS_repeat; cl11982
859656000603	RHS Repeat; Region: RHS_repeat; pfam05593
859656000604	RHS Repeat; Region: RHS_repeat; pfam05593
859656000605	RHS Repeat; Region: RHS_repeat; cl11982
859656000606	RHS Repeat; Region: RHS_repeat; pfam05593
859656000607	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process
859656000608	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
859656000609	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
859656000610	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859656000611	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
859656000612	Predicted integral membrane protein [Function unknown]; Region: COG5616
859656000613	TPR repeat; Region: TPR_11; pfam13414
859656000614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000615	TPR motif; other site
859656000616	binding surface
859656000617	TPR repeat; Region: TPR_11; pfam13414
859656000618	TPR repeat; Region: TPR_11; pfam13414
859656000619	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000620	binding surface
859656000621	TPR motif; other site
859656000622	TPR repeat; Region: TPR_11; pfam13414
859656000623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000624	binding surface
859656000625	TPR motif; other site
859656000626	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
859656000627	ligand-binding site [chemical binding]; other site
859656000628	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859656000629	Tetratricopeptide repeat; Region: TPR_16; pfam13432
859656000630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000631	binding surface
859656000632	TPR motif; other site
859656000633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
859656000634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000635	binding surface
859656000636	TPR motif; other site
859656000637	TPR repeat; Region: TPR_11; pfam13414
859656000638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000639	binding surface
859656000640	TPR motif; other site
859656000641	TPR repeat; Region: TPR_11; pfam13414
859656000642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656000643	TPR motif; other site
859656000644	binding surface
859656000645	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
859656000646	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
859656000647	Autotransporter beta-domain; Region: Autotransporter; pfam03797
859656000648	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656000649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000650	active site
859656000651	phosphorylation site [posttranslational modification]
859656000652	intermolecular recognition site; other site
859656000653	dimerization interface [polypeptide binding]; other site
859656000654	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656000655	dimerization interface [polypeptide binding]; other site
859656000656	DNA binding residues [nucleotide binding]
859656000657	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
859656000658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000659	ATP binding site [chemical binding]; other site
859656000660	Mg2+ binding site [ion binding]; other site
859656000661	G-X-G motif; other site
859656000662	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
859656000663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656000664	S-adenosylmethionine binding site [chemical binding]; other site
859656000665	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859656000666	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
859656000667	Methyltransferase domain; Region: Methyltransf_32; pfam13679
859656000668	Methyltransferase domain; Region: Methyltransf_31; pfam13847
859656000669	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656000670	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
859656000671	Predicted transcriptional regulators [Transcription]; Region: COG1733
859656000672	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859656000673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4922
859656000674	transaminase; Validated; Region: PRK07324
859656000675	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656000676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656000677	homodimer interface [polypeptide binding]; other site
859656000678	catalytic residue [active]
859656000679	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859656000680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656000681	NAD(P) binding site [chemical binding]; other site
859656000682	active site
859656000683	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
859656000684	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859656000685	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656000686	catalytic residue [active]
859656000687	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
859656000688	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656000689	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
859656000690	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656000691	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
859656000692	active site
859656000693	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
859656000694	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
859656000695	Cytochrome c; Region: Cytochrom_C; pfam00034
859656000696	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656000697	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656000698	non-specific DNA binding site [nucleotide binding]; other site
859656000699	salt bridge; other site
859656000700	sequence-specific DNA binding site [nucleotide binding]; other site
859656000701	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656000702	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859656000703	putative ligand binding site [chemical binding]; other site
859656000704	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859656000705	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656000706	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656000707	metal binding site [ion binding]; metal-binding site
859656000708	active site
859656000709	I-site; other site
859656000710	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
859656000711	active site
859656000712	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656000713	MarR family; Region: MarR_2; cl17246
859656000714	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859656000715	classical (c) SDRs; Region: SDR_c; cd05233
859656000716	NAD(P) binding site [chemical binding]; other site
859656000717	active site
859656000718	Uncharacterized conserved protein [Function unknown]; Region: COG3868
859656000719	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
859656000720	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
859656000721	putative active site [active]
859656000722	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859656000723	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656000724	dimer interface [polypeptide binding]; other site
859656000725	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
859656000726	putative CheW interface [polypeptide binding]; other site
859656000727	LabA_like proteins; Region: LabA_like; cd06167
859656000728	putative metal binding site [ion binding]; other site
859656000729	Uncharacterized conserved protein [Function unknown]; Region: COG1432
859656000730	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
859656000731	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
859656000732	dinuclear metal binding motif [ion binding]; other site
859656000733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656000734	putative substrate translocation pore; other site
859656000735	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
859656000736	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
859656000737	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
859656000738	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656000739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656000740	non-specific DNA binding site [nucleotide binding]; other site
859656000741	salt bridge; other site
859656000742	sequence-specific DNA binding site [nucleotide binding]; other site
859656000743	Cupin domain; Region: Cupin_2; cl17218
859656000744	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859656000745	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
859656000746	putative ligand binding site [chemical binding]; other site
859656000747	putative NAD binding site [chemical binding]; other site
859656000748	catalytic site [active]
859656000749	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859656000750	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
859656000751	NAD binding site [chemical binding]; other site
859656000752	substrate binding site [chemical binding]; other site
859656000753	catalytic Zn binding site [ion binding]; other site
859656000754	tetramer interface [polypeptide binding]; other site
859656000755	structural Zn binding site [ion binding]; other site
859656000756	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
859656000757	PAS domain; Region: PAS; smart00091
859656000758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656000759	Walker A motif; other site
859656000760	ATP binding site [chemical binding]; other site
859656000761	Walker B motif; other site
859656000762	arginine finger; other site
859656000763	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656000764	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859656000765	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656000766	NAD(P) binding site [chemical binding]; other site
859656000767	catalytic residues [active]
859656000768	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
859656000769	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
859656000770	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
859656000771	exonuclease I; Provisional; Region: sbcB; PRK11779
859656000772	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
859656000773	active site
859656000774	catalytic site [active]
859656000775	substrate binding site [chemical binding]; other site
859656000776	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
859656000777	Evidence 4 : Homologs of previously reported genes of unknown function
859656000778	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
859656000779	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
859656000780	dimer interface [polypeptide binding]; other site
859656000781	PYR/PP interface [polypeptide binding]; other site
859656000782	TPP binding site [chemical binding]; other site
859656000783	substrate binding site [chemical binding]; other site
859656000784	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
859656000785	TPP-binding site; other site
859656000786	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
859656000787	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859656000788	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656000789	DNA-binding site [nucleotide binding]; DNA binding site
859656000790	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656000791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656000792	homodimer interface [polypeptide binding]; other site
859656000793	catalytic residue [active]
859656000794	Evidence 2b : Function of strongly homologous gene; PubMedId : 10419967, 2124971; Product type t : transporter
859656000795	Evidence 2b : Function of strongly homologous gene; PubMedId : 10419967, 2124971; Product type t : transporter
859656000796	type II secretion system protein E; Region: type_II_gspE; TIGR02533
859656000797	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859656000798	Walker A motif; other site
859656000799	ATP binding site [chemical binding]; other site
859656000800	Walker B motif; other site
859656000801	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656000802	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656000803	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656000804	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
859656000805	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656000806	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
859656000807	Type II secretory pathway, component PulM [Intracellular trafficking and secretion]; Region: PulM; COG3149
859656000808	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
859656000809	GspL periplasmic domain; Region: GspL_C; pfam12693
859656000810	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
859656000811	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
859656000812	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
859656000813	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
859656000814	Type II transport protein GspH; Region: GspH; pfam12019
859656000815	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
859656000816	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656000817	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
859656000818	EF-hand domain pair; Region: EF_hand_5; pfam13499
859656000819	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
859656000820	EF-hand domain pair; Region: EF_hand_5; pfam13499
859656000821	Ca2+ binding site [ion binding]; other site
859656000822	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
859656000823	EF-hand domain pair; Region: EF_hand_5; pfam13499
859656000824	Ca2+ binding site [ion binding]; other site
859656000825	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
859656000826	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
859656000827	dimer interface [polypeptide binding]; other site
859656000828	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
859656000829	active site
859656000830	Fe binding site [ion binding]; other site
859656000831	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656000832	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656000833	putative DNA binding site [nucleotide binding]; other site
859656000834	putative Zn2+ binding site [ion binding]; other site
859656000835	AsnC family; Region: AsnC_trans_reg; pfam01037
859656000836	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
859656000837	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859656000838	putative active site [active]
859656000839	putative catalytic triad [active]
859656000840	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859656000841	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
859656000842	SnoaL-like domain; Region: SnoaL_3; pfam13474
859656000843	Cupin domain; Region: Cupin_2; cl17218
859656000844	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
859656000845	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656000846	Coenzyme A binding pocket [chemical binding]; other site
859656000847	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
859656000848	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656000849	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
859656000850	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
859656000851	TrkA-N domain; Region: TrkA_N; pfam02254
859656000852	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
859656000853	Protein of unknown function; Region: DUF3658; pfam12395
859656000854	glutamate carboxypeptidase; Reviewed; Region: PRK06133
859656000855	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
859656000856	metal binding site [ion binding]; metal-binding site
859656000857	dimer interface [polypeptide binding]; other site
859656000858	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656000859	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656000860	trimer interface [polypeptide binding]; other site
859656000861	eyelet of channel; other site
859656000862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
859656000863	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
859656000864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000865	active site
859656000866	phosphorylation site [posttranslational modification]
859656000867	intermolecular recognition site; other site
859656000868	dimerization interface [polypeptide binding]; other site
859656000869	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656000870	DNA binding site [nucleotide binding]
859656000871	High potential iron-sulfur protein; Region: HIPIP; pfam01355
859656000872	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
859656000873	Helix-turn-helix domain; Region: HTH_17; cl17695
859656000874	PIN domain; Region: PIN_3; pfam13470
859656000875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859656000876	HTH-like domain; Region: HTH_21; pfam13276
859656000877	Integrase core domain; Region: rve; pfam00665
859656000878	Integrase core domain; Region: rve_3; pfam13683
859656000879	Transposase; Region: HTH_Tnp_1; pfam01527
859656000880	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
859656000881	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
859656000882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656000883	PAS domain; Region: PAS_9; pfam13426
859656000884	putative active site [active]
859656000885	heme pocket [chemical binding]; other site
859656000886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656000887	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656000888	dimer interface [polypeptide binding]; other site
859656000889	phosphorylation site [posttranslational modification]
859656000890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000891	ATP binding site [chemical binding]; other site
859656000892	Mg2+ binding site [ion binding]; other site
859656000893	G-X-G motif; other site
859656000894	Response regulator receiver domain; Region: Response_reg; pfam00072
859656000895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000896	active site
859656000897	phosphorylation site [posttranslational modification]
859656000898	intermolecular recognition site; other site
859656000899	dimerization interface [polypeptide binding]; other site
859656000900	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656000901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000902	active site
859656000903	phosphorylation site [posttranslational modification]
859656000904	intermolecular recognition site; other site
859656000905	dimerization interface [polypeptide binding]; other site
859656000906	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656000907	DNA binding residues [nucleotide binding]
859656000908	dimerization interface [polypeptide binding]; other site
859656000909	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
859656000910	Cation efflux family; Region: Cation_efflux; cl00316
859656000911	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
859656000912	GSH binding site (G-site) [chemical binding]; other site
859656000913	C-terminal domain interface [polypeptide binding]; other site
859656000914	dimer interface [polypeptide binding]; other site
859656000915	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
859656000916	N-terminal domain interface [polypeptide binding]; other site
859656000917	dimer interface [polypeptide binding]; other site
859656000918	substrate binding pocket (H-site) [chemical binding]; other site
859656000919	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859656000920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656000921	putative substrate translocation pore; other site
859656000922	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
859656000923	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859656000924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
859656000925	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
859656000926	MltA-interacting protein MipA; Region: MipA; pfam06629
859656000927	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656000928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656000929	active site
859656000930	phosphorylation site [posttranslational modification]
859656000931	intermolecular recognition site; other site
859656000932	dimerization interface [polypeptide binding]; other site
859656000933	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656000934	DNA binding site [nucleotide binding]
859656000935	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
859656000936	HAMP domain; Region: HAMP; pfam00672
859656000937	dimerization interface [polypeptide binding]; other site
859656000938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656000939	dimer interface [polypeptide binding]; other site
859656000940	phosphorylation site [posttranslational modification]
859656000941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656000942	ATP binding site [chemical binding]; other site
859656000943	Mg2+ binding site [ion binding]; other site
859656000944	G-X-G motif; other site
859656000945	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
859656000946	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656000947	Helix-turn-helix domain; Region: HTH_18; pfam12833
859656000948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656000949	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859656000950	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656000951	putative ligand binding site [chemical binding]; other site
859656000952	citrate-proton symporter; Provisional; Region: PRK15075
859656000953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656000954	putative substrate translocation pore; other site
859656000955	citrate-proton symporter; Provisional; Region: PRK15075
859656000956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656000957	putative substrate translocation pore; other site
859656000958	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
859656000959	dimerization interface [polypeptide binding]; other site
859656000960	putative active cleft [active]
859656000961	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
859656000962	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
859656000963	Protein of unknown function (DUF1415); Region: DUF1415; cl01301
859656000964	Integral membrane protein DUF106; Region: DUF106; pfam01956
859656000965	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
859656000966	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
859656000967	N- and C-terminal domain interface [polypeptide binding]; other site
859656000968	active site
859656000969	MgATP binding site [chemical binding]; other site
859656000970	catalytic site [active]
859656000971	metal binding site [ion binding]; metal-binding site
859656000972	glycerol binding site [chemical binding]; other site
859656000973	homotetramer interface [polypeptide binding]; other site
859656000974	homodimer interface [polypeptide binding]; other site
859656000975	FBP binding site [chemical binding]; other site
859656000976	protein IIAGlc interface [polypeptide binding]; other site
859656000977	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
859656000978	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
859656000979	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
859656000980	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
859656000981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656000982	dimer interface [polypeptide binding]; other site
859656000983	conserved gate region; other site
859656000984	putative PBP binding loops; other site
859656000985	ABC-ATPase subunit interface; other site
859656000986	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859656000987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656000988	dimer interface [polypeptide binding]; other site
859656000989	conserved gate region; other site
859656000990	putative PBP binding loops; other site
859656000991	ABC-ATPase subunit interface; other site
859656000992	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
859656000993	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859656000994	Walker A/P-loop; other site
859656000995	ATP binding site [chemical binding]; other site
859656000996	Q-loop/lid; other site
859656000997	ABC transporter signature motif; other site
859656000998	Walker B; other site
859656000999	D-loop; other site
859656001000	H-loop/switch region; other site
859656001001	TOBE domain; Region: TOBE_2; pfam08402
859656001002	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
859656001003	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859656001004	Walker A/P-loop; other site
859656001005	ATP binding site [chemical binding]; other site
859656001006	Q-loop/lid; other site
859656001007	ABC transporter signature motif; other site
859656001008	Walker B; other site
859656001009	D-loop; other site
859656001010	H-loop/switch region; other site
859656001011	TOBE domain; Region: TOBE_2; pfam08402
859656001012	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
859656001013	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
859656001014	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
859656001015	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
859656001016	CHAD domain; Region: CHAD; cl10506
859656001017	elongation factor Tu; Reviewed; Region: PRK00049
859656001018	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
859656001019	G1 box; other site
859656001020	GEF interaction site [polypeptide binding]; other site
859656001021	GTP/Mg2+ binding site [chemical binding]; other site
859656001022	Switch I region; other site
859656001023	G2 box; other site
859656001024	G3 box; other site
859656001025	Switch II region; other site
859656001026	G4 box; other site
859656001027	G5 box; other site
859656001028	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
859656001029	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
859656001030	Antibiotic Binding Site [chemical binding]; other site
859656001031	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
859656001032	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
859656001033	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
859656001034	putative homodimer interface [polypeptide binding]; other site
859656001035	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
859656001036	heterodimer interface [polypeptide binding]; other site
859656001037	homodimer interface [polypeptide binding]; other site
859656001038	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
859656001039	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
859656001040	23S rRNA interface [nucleotide binding]; other site
859656001041	L7/L12 interface [polypeptide binding]; other site
859656001042	putative thiostrepton binding site; other site
859656001043	L25 interface [polypeptide binding]; other site
859656001044	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
859656001045	mRNA/rRNA interface [nucleotide binding]; other site
859656001046	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
859656001047	23S rRNA interface [nucleotide binding]; other site
859656001048	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
859656001049	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
859656001050	core dimer interface [polypeptide binding]; other site
859656001051	peripheral dimer interface [polypeptide binding]; other site
859656001052	L10 interface [polypeptide binding]; other site
859656001053	L11 interface [polypeptide binding]; other site
859656001054	putative EF-Tu interaction site [polypeptide binding]; other site
859656001055	putative EF-G interaction site [polypeptide binding]; other site
859656001056	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
859656001057	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
859656001058	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
859656001059	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
859656001060	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
859656001061	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
859656001062	RPB3 interaction site [polypeptide binding]; other site
859656001063	RPB1 interaction site [polypeptide binding]; other site
859656001064	RPB11 interaction site [polypeptide binding]; other site
859656001065	RPB10 interaction site [polypeptide binding]; other site
859656001066	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
859656001067	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
859656001068	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
859656001069	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
859656001070	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
859656001071	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
859656001072	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
859656001073	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
859656001074	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
859656001075	DNA binding site [nucleotide binding]
859656001076	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
859656001077	Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909
859656001078	Protein of unknown function (DUF1175); Region: DUF1175; cl14898
859656001079	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
859656001080	MG2 domain; Region: A2M_N; pfam01835
859656001081	Alpha-2-macroglobulin family; Region: A2M; pfam00207
859656001082	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
859656001083	Predicted secreted protein [Function unknown]; Region: COG5445
859656001084	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
859656001085	Predicted secreted protein [Function unknown]; Region: COG5445
859656001086	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
859656001087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
859656001088	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
859656001089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
859656001090	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
859656001091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656001092	S-adenosylmethionine binding site [chemical binding]; other site
859656001093	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
859656001094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656001095	ATP binding site [chemical binding]; other site
859656001096	putative Mg++ binding site [ion binding]; other site
859656001097	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656001098	nucleotide binding region [chemical binding]; other site
859656001099	ATP-binding site [chemical binding]; other site
859656001100	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
859656001101	HRDC domain; Region: HRDC; pfam00570
859656001102	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
859656001103	S17 interaction site [polypeptide binding]; other site
859656001104	S8 interaction site; other site
859656001105	16S rRNA interaction site [nucleotide binding]; other site
859656001106	streptomycin interaction site [chemical binding]; other site
859656001107	23S rRNA interaction site [nucleotide binding]; other site
859656001108	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
859656001109	30S ribosomal protein S7; Validated; Region: PRK05302
859656001110	elongation factor G; Reviewed; Region: PRK00007
859656001111	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
859656001112	G1 box; other site
859656001113	putative GEF interaction site [polypeptide binding]; other site
859656001114	GTP/Mg2+ binding site [chemical binding]; other site
859656001115	Switch I region; other site
859656001116	G2 box; other site
859656001117	G3 box; other site
859656001118	Switch II region; other site
859656001119	G4 box; other site
859656001120	G5 box; other site
859656001121	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
859656001122	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
859656001123	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
859656001124	elongation factor Tu; Reviewed; Region: PRK00049
859656001125	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
859656001126	G1 box; other site
859656001127	GEF interaction site [polypeptide binding]; other site
859656001128	GTP/Mg2+ binding site [chemical binding]; other site
859656001129	Switch I region; other site
859656001130	G2 box; other site
859656001131	G3 box; other site
859656001132	Switch II region; other site
859656001133	G4 box; other site
859656001134	G5 box; other site
859656001135	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
859656001136	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
859656001137	Antibiotic Binding Site [chemical binding]; other site
859656001138	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
859656001139	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
859656001140	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
859656001141	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
859656001142	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
859656001143	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
859656001144	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
859656001145	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
859656001146	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
859656001147	putative translocon binding site; other site
859656001148	protein-rRNA interface [nucleotide binding]; other site
859656001149	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
859656001150	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
859656001151	G-X-X-G motif; other site
859656001152	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
859656001153	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
859656001154	23S rRNA interface [nucleotide binding]; other site
859656001155	5S rRNA interface [nucleotide binding]; other site
859656001156	putative antibiotic binding site [chemical binding]; other site
859656001157	L25 interface [polypeptide binding]; other site
859656001158	L27 interface [polypeptide binding]; other site
859656001159	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
859656001160	23S rRNA interface [nucleotide binding]; other site
859656001161	putative translocon interaction site; other site
859656001162	signal recognition particle (SRP54) interaction site; other site
859656001163	L23 interface [polypeptide binding]; other site
859656001164	trigger factor interaction site; other site
859656001165	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
859656001166	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
859656001167	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
859656001168	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
859656001169	RNA binding site [nucleotide binding]; other site
859656001170	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
859656001171	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
859656001172	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
859656001173	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
859656001174	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
859656001175	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
859656001176	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
859656001177	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
859656001178	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
859656001179	5S rRNA interface [nucleotide binding]; other site
859656001180	L27 interface [polypeptide binding]; other site
859656001181	23S rRNA interface [nucleotide binding]; other site
859656001182	L5 interface [polypeptide binding]; other site
859656001183	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
859656001184	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
859656001185	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
859656001186	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
859656001187	23S rRNA binding site [nucleotide binding]; other site
859656001188	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
859656001189	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
859656001190	SecY translocase; Region: SecY; pfam00344
859656001191	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
859656001192	rRNA binding site [nucleotide binding]; other site
859656001193	predicted 30S ribosome binding site; other site
859656001194	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
859656001195	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
859656001196	30S ribosomal protein S13; Region: bact_S13; TIGR03631
859656001197	30S ribosomal protein S11; Validated; Region: PRK05309
859656001198	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
859656001199	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
859656001200	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656001201	RNA binding surface [nucleotide binding]; other site
859656001202	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
859656001203	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
859656001204	alphaNTD homodimer interface [polypeptide binding]; other site
859656001205	alphaNTD - beta interaction site [polypeptide binding]; other site
859656001206	alphaNTD - beta' interaction site [polypeptide binding]; other site
859656001207	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
859656001208	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
859656001209	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
859656001210	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
859656001211	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
859656001212	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
859656001213	DsbD alpha interface [polypeptide binding]; other site
859656001214	catalytic residues [active]
859656001215	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
859656001216	dimer interface [polypeptide binding]; other site
859656001217	active site
859656001218	aspartate-rich active site metal binding site; other site
859656001219	allosteric magnesium binding site [ion binding]; other site
859656001220	Schiff base residues; other site
859656001221	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
859656001222	G1 box; other site
859656001223	GTP/Mg2+ binding site [chemical binding]; other site
859656001224	Switch I region; other site
859656001225	G2 box; other site
859656001226	G3 box; other site
859656001227	Switch II region; other site
859656001228	G4 box; other site
859656001229	G5 box; other site
859656001230	Cytochrome c553 [Energy production and conversion]; Region: COG2863
859656001231	Cytochrome c; Region: Cytochrom_C; cl11414
859656001232	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
859656001233	ResB-like family; Region: ResB; pfam05140
859656001234	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
859656001235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
859656001236	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
859656001237	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
859656001238	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859656001239	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656001240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656001241	DNA binding residues [nucleotide binding]
859656001242	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
859656001243	TMAO/DMSO reductase; Reviewed; Region: PRK05363
859656001244	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
859656001245	Moco binding site; other site
859656001246	metal coordination site [ion binding]; other site
859656001247	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
859656001248	diaminopimelate decarboxylase; Region: lysA; TIGR01048
859656001249	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
859656001250	active site
859656001251	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656001252	substrate binding site [chemical binding]; other site
859656001253	catalytic residues [active]
859656001254	dimer interface [polypeptide binding]; other site
859656001255	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
859656001256	putative iron binding site [ion binding]; other site
859656001257	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
859656001258	Transglycosylase; Region: Transgly; pfam00912
859656001259	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
859656001260	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
859656001261	Cell division protein FtsA; Region: FtsA; cl17206
859656001262	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
859656001263	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
859656001264	Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167
859656001265	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
859656001266	Pilus assembly protein, PilP; Region: PilP; pfam04351
859656001267	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
859656001268	AMIN domain; Region: AMIN; pfam11741
859656001269	Secretin and TonB N terminus short domain; Region: STN; smart00965
859656001270	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656001271	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656001272	shikimate kinase; Reviewed; Region: aroK; PRK00131
859656001273	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
859656001274	ADP binding site [chemical binding]; other site
859656001275	magnesium binding site [ion binding]; other site
859656001276	putative shikimate binding site; other site
859656001277	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
859656001278	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
859656001279	active site
859656001280	dimer interface [polypeptide binding]; other site
859656001281	metal binding site [ion binding]; metal-binding site
859656001282	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
859656001283	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656001284	Zn2+ binding site [ion binding]; other site
859656001285	Mg2+ binding site [ion binding]; other site
859656001286	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
859656001287	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
859656001288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
859656001289	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
859656001290	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
859656001291	active site
859656001292	dimer interface [polypeptide binding]; other site
859656001293	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
859656001294	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
859656001295	active site
859656001296	FMN binding site [chemical binding]; other site
859656001297	substrate binding site [chemical binding]; other site
859656001298	3Fe-4S cluster binding site [ion binding]; other site
859656001299	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
859656001300	domain interface; other site
859656001301	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
859656001302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859656001303	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859656001304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
859656001305	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
859656001306	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
859656001307	Walker A/P-loop; other site
859656001308	ATP binding site [chemical binding]; other site
859656001309	Q-loop/lid; other site
859656001310	ABC transporter signature motif; other site
859656001311	Walker B; other site
859656001312	D-loop; other site
859656001313	H-loop/switch region; other site
859656001314	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
859656001315	Permease; Region: Permease; pfam02405
859656001316	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
859656001317	mce related protein; Region: MCE; pfam02470
859656001318	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
859656001319	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
859656001320	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
859656001321	anti sigma factor interaction site; other site
859656001322	regulatory phosphorylation site [posttranslational modification]; other site
859656001323	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
859656001324	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
859656001325	Walker A/P-loop; other site
859656001326	ATP binding site [chemical binding]; other site
859656001327	Q-loop/lid; other site
859656001328	ABC transporter signature motif; other site
859656001329	Walker B; other site
859656001330	D-loop; other site
859656001331	H-loop/switch region; other site
859656001332	ABC-2 type transporter; Region: ABC2_membrane; cl17235
859656001333	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
859656001334	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
859656001335	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
859656001336	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
859656001337	hinge; other site
859656001338	active site
859656001339	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
859656001340	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
859656001341	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
859656001342	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
859656001343	NAD binding site [chemical binding]; other site
859656001344	dimerization interface [polypeptide binding]; other site
859656001345	product binding site; other site
859656001346	substrate binding site [chemical binding]; other site
859656001347	zinc binding site [ion binding]; other site
859656001348	catalytic residues [active]
859656001349	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
859656001350	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656001351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656001352	homodimer interface [polypeptide binding]; other site
859656001353	catalytic residue [active]
859656001354	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
859656001355	putative active site pocket [active]
859656001356	4-fold oligomerization interface [polypeptide binding]; other site
859656001357	metal binding residues [ion binding]; metal-binding site
859656001358	3-fold/trimer interface [polypeptide binding]; other site
859656001359	MarC family integral membrane protein; Region: MarC; cl00919
859656001360	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
859656001361	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
859656001362	putative active site [active]
859656001363	oxyanion strand; other site
859656001364	catalytic triad [active]
859656001365	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
859656001366	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
859656001367	catalytic residues [active]
859656001368	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
859656001369	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
859656001370	substrate binding site [chemical binding]; other site
859656001371	glutamase interaction surface [polypeptide binding]; other site
859656001372	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
859656001373	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
859656001374	metal binding site [ion binding]; metal-binding site
859656001375	Predicted membrane protein [Function unknown]; Region: COG3671
859656001376	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
859656001377	sec-independent translocase; Provisional; Region: tatB; PRK01919
859656001378	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
859656001379	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859656001380	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
859656001381	Walker A/P-loop; other site
859656001382	ATP binding site [chemical binding]; other site
859656001383	Q-loop/lid; other site
859656001384	ABC transporter signature motif; other site
859656001385	Walker B; other site
859656001386	D-loop; other site
859656001387	H-loop/switch region; other site
859656001388	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
859656001389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656001390	dimer interface [polypeptide binding]; other site
859656001391	conserved gate region; other site
859656001392	ABC-ATPase subunit interface; other site
859656001393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656001394	dimer interface [polypeptide binding]; other site
859656001395	conserved gate region; other site
859656001396	putative PBP binding loops; other site
859656001397	ABC-ATPase subunit interface; other site
859656001398	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859656001399	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
859656001400	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859656001401	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656001402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656001403	dimer interface [polypeptide binding]; other site
859656001404	phosphorylation site [posttranslational modification]
859656001405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656001406	ATP binding site [chemical binding]; other site
859656001407	Mg2+ binding site [ion binding]; other site
859656001408	G-X-G motif; other site
859656001409	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
859656001410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656001411	active site
859656001412	phosphorylation site [posttranslational modification]
859656001413	intermolecular recognition site; other site
859656001414	dimerization interface [polypeptide binding]; other site
859656001415	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656001416	DNA binding site [nucleotide binding]
859656001417	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859656001418	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859656001419	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656001420	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656001421	trimer interface [polypeptide binding]; other site
859656001422	eyelet of channel; other site
859656001423	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
859656001424	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859656001425	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859656001426	protein binding site [polypeptide binding]; other site
859656001427	Uncharacterized conserved protein [Function unknown]; Region: COG0327
859656001428	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
859656001429	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
859656001430	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
859656001431	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
859656001432	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
859656001433	[2Fe-2S] cluster binding site [ion binding]; other site
859656001434	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
859656001435	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
859656001436	Qi binding site; other site
859656001437	intrachain domain interface; other site
859656001438	interchain domain interface [polypeptide binding]; other site
859656001439	heme bH binding site [chemical binding]; other site
859656001440	heme bL binding site [chemical binding]; other site
859656001441	Qo binding site; other site
859656001442	interchain domain interface [polypeptide binding]; other site
859656001443	intrachain domain interface; other site
859656001444	Qi binding site; other site
859656001445	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
859656001446	Qo binding site; other site
859656001447	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
859656001448	Cytochrome c; Region: Cytochrom_C; cl11414
859656001449	stringent starvation protein A; Provisional; Region: sspA; PRK09481
859656001450	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
859656001451	C-terminal domain interface [polypeptide binding]; other site
859656001452	putative GSH binding site (G-site) [chemical binding]; other site
859656001453	dimer interface [polypeptide binding]; other site
859656001454	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
859656001455	dimer interface [polypeptide binding]; other site
859656001456	N-terminal domain interface [polypeptide binding]; other site
859656001457	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
859656001458	transcriptional regulator; Provisional; Region: PRK10632
859656001459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656001460	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
859656001461	putative effector binding pocket; other site
859656001462	putative dimerization interface [polypeptide binding]; other site
859656001463	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
859656001464	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656001465	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
859656001466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656001467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656001468	dimer interface [polypeptide binding]; other site
859656001469	phosphorylation site [posttranslational modification]
859656001470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656001471	ATP binding site [chemical binding]; other site
859656001472	Mg2+ binding site [ion binding]; other site
859656001473	G-X-G motif; other site
859656001474	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
859656001475	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859656001476	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
859656001477	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
859656001478	Secretin and TonB N terminus short domain; Region: STN; smart00965
859656001479	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
859656001480	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656001481	N-terminal plug; other site
859656001482	ligand-binding site [chemical binding]; other site
859656001483	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
859656001484	FecR protein; Region: FecR; pfam04773
859656001485	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859656001486	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656001487	DNA binding residues [nucleotide binding]
859656001488	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
859656001489	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859656001490	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
859656001491	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
859656001492	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
859656001493	D-pathway; other site
859656001494	Putative ubiquinol binding site [chemical binding]; other site
859656001495	Low-spin heme (heme b) binding site [chemical binding]; other site
859656001496	Putative water exit pathway; other site
859656001497	Binuclear center (heme o3/CuB) [ion binding]; other site
859656001498	K-pathway; other site
859656001499	Putative proton exit pathway; other site
859656001500	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
859656001501	Subunit I/III interface [polypeptide binding]; other site
859656001502	Subunit III/IV interface [polypeptide binding]; other site
859656001503	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
859656001504	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
859656001505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656001506	Walker A/P-loop; other site
859656001507	ATP binding site [chemical binding]; other site
859656001508	Q-loop/lid; other site
859656001509	ABC transporter signature motif; other site
859656001510	Walker B; other site
859656001511	D-loop; other site
859656001512	H-loop/switch region; other site
859656001513	ABC transporter; Region: ABC_tran_2; pfam12848
859656001514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656001515	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
859656001516	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
859656001517	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
859656001518	putative deacylase active site [active]
859656001519	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
859656001520	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
859656001521	Ligand binding site; other site
859656001522	DXD motif; other site
859656001523	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
859656001524	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
859656001525	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
859656001526	Flavoprotein; Region: Flavoprotein; pfam02441
859656001527	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
859656001528	putative GSH binding site [chemical binding]; other site
859656001529	catalytic residues [active]
859656001530	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
859656001531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656001532	S-adenosylmethionine binding site [chemical binding]; other site
859656001533	peptide chain release factor 1; Validated; Region: prfA; PRK00591
859656001534	This domain is found in peptide chain release factors; Region: PCRF; smart00937
859656001535	RF-1 domain; Region: RF-1; pfam00472
859656001536	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
859656001537	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
859656001538	tRNA; other site
859656001539	putative tRNA binding site [nucleotide binding]; other site
859656001540	putative NADP binding site [chemical binding]; other site
859656001541	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
859656001542	GTP-binding protein YchF; Reviewed; Region: PRK09601
859656001543	YchF GTPase; Region: YchF; cd01900
859656001544	G1 box; other site
859656001545	GTP/Mg2+ binding site [chemical binding]; other site
859656001546	Switch I region; other site
859656001547	G2 box; other site
859656001548	Switch II region; other site
859656001549	G3 box; other site
859656001550	G4 box; other site
859656001551	G5 box; other site
859656001552	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
859656001553	Flagellar protein FliT; Region: FliT; pfam05400
859656001554	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656001555	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656001556	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656001557	catalytic residue [active]
859656001558	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
859656001559	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
859656001560	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
859656001561	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
859656001562	dimerization domain [polypeptide binding]; other site
859656001563	dimer interface [polypeptide binding]; other site
859656001564	catalytic residues [active]
859656001565	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
859656001566	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
859656001567	NADP binding site [chemical binding]; other site
859656001568	dimer interface [polypeptide binding]; other site
859656001569	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
859656001570	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
859656001571	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859656001572	protein binding site [polypeptide binding]; other site
859656001573	Predicted membrane protein [Function unknown]; Region: COG1289
859656001574	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
859656001575	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
859656001576	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
859656001577	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
859656001578	ligand binding site [chemical binding]; other site
859656001579	active site
859656001580	UGI interface [polypeptide binding]; other site
859656001581	catalytic site [active]
859656001582	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
859656001583	putative active site [active]
859656001584	putative metal binding residues [ion binding]; other site
859656001585	signature motif; other site
859656001586	putative triphosphate binding site [ion binding]; other site
859656001587	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
859656001588	active site
859656001589	ribulose/triose binding site [chemical binding]; other site
859656001590	phosphate binding site [ion binding]; other site
859656001591	substrate (anthranilate) binding pocket [chemical binding]; other site
859656001592	product (indole) binding pocket [chemical binding]; other site
859656001593	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
859656001594	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859656001595	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
859656001596	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
859656001597	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
859656001598	glutamine binding [chemical binding]; other site
859656001599	catalytic triad [active]
859656001600	anthranilate synthase component I; Provisional; Region: PRK13565
859656001601	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
859656001602	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
859656001603	phosphoglycolate phosphatase; Provisional; Region: PRK13222
859656001604	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656001605	motif II; other site
859656001606	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
859656001607	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
859656001608	substrate binding site [chemical binding]; other site
859656001609	hexamer interface [polypeptide binding]; other site
859656001610	metal binding site [ion binding]; metal-binding site
859656001611	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
859656001612	putative assembly protein; Region: PHA00350
859656001613	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
859656001614	MltA specific insert domain; Region: MltA; smart00925
859656001615	3D domain; Region: 3D; pfam06725
859656001616	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656001617	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
859656001618	acyl-activating enzyme (AAE) consensus motif; other site
859656001619	AMP binding site [chemical binding]; other site
859656001620	active site
859656001621	CoA binding site [chemical binding]; other site
859656001622	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859656001623	CoenzymeA binding site [chemical binding]; other site
859656001624	subunit interaction site [polypeptide binding]; other site
859656001625	PHB binding site; other site
859656001626	enoyl-CoA hydratase; Provisional; Region: PRK08140
859656001627	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656001628	substrate binding site [chemical binding]; other site
859656001629	oxyanion hole (OAH) forming residues; other site
859656001630	trimer interface [polypeptide binding]; other site
859656001631	enoyl-CoA hydratase; Provisional; Region: PRK05862
859656001632	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656001633	substrate binding site [chemical binding]; other site
859656001634	oxyanion hole (OAH) forming residues; other site
859656001635	trimer interface [polypeptide binding]; other site
859656001636	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
859656001637	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
859656001638	metal binding site [ion binding]; metal-binding site
859656001639	putative dimer interface [polypeptide binding]; other site
859656001640	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859656001641	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859656001642	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859656001643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656001644	dimer interface [polypeptide binding]; other site
859656001645	conserved gate region; other site
859656001646	putative PBP binding loops; other site
859656001647	ABC-ATPase subunit interface; other site
859656001648	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
859656001649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656001650	dimer interface [polypeptide binding]; other site
859656001651	conserved gate region; other site
859656001652	putative PBP binding loops; other site
859656001653	ABC-ATPase subunit interface; other site
859656001654	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
859656001655	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656001656	Walker A/P-loop; other site
859656001657	ATP binding site [chemical binding]; other site
859656001658	Q-loop/lid; other site
859656001659	ABC transporter signature motif; other site
859656001660	Walker B; other site
859656001661	D-loop; other site
859656001662	H-loop/switch region; other site
859656001663	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859656001664	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
859656001665	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656001666	Walker A/P-loop; other site
859656001667	ATP binding site [chemical binding]; other site
859656001668	Q-loop/lid; other site
859656001669	ABC transporter signature motif; other site
859656001670	Walker B; other site
859656001671	D-loop; other site
859656001672	H-loop/switch region; other site
859656001673	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
859656001674	acetylornithine deacetylase; Provisional; Region: PRK07522
859656001675	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
859656001676	metal binding site [ion binding]; metal-binding site
859656001677	putative dimer interface [polypeptide binding]; other site
859656001678	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656001679	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859656001680	putative ligand binding site [chemical binding]; other site
859656001681	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
859656001682	active site
859656001683	P-loop; other site
859656001684	phosphorylation site [posttranslational modification]
859656001685	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
859656001686	active site
859656001687	P-loop; other site
859656001688	phosphorylation site [posttranslational modification]
859656001689	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
859656001690	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
859656001691	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
859656001692	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
859656001693	putative substrate binding site [chemical binding]; other site
859656001694	putative ATP binding site [chemical binding]; other site
859656001695	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
859656001696	active site
859656001697	phosphorylation site [posttranslational modification]
859656001698	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
859656001699	dimerization domain swap beta strand [polypeptide binding]; other site
859656001700	regulatory protein interface [polypeptide binding]; other site
859656001701	active site
859656001702	regulatory phosphorylation site [posttranslational modification]; other site
859656001703	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
859656001704	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
859656001705	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859656001706	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859656001707	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859656001708	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656001709	DNA binding site [nucleotide binding]
859656001710	domain linker motif; other site
859656001711	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
859656001712	putative dimerization interface [polypeptide binding]; other site
859656001713	putative ligand binding site [chemical binding]; other site
859656001714	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859656001715	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
859656001716	putative [4Fe-4S] binding site [ion binding]; other site
859656001717	putative molybdopterin cofactor binding site [chemical binding]; other site
859656001718	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
859656001719	putative molybdopterin cofactor binding site; other site
859656001720	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
859656001721	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
859656001722	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
859656001723	acyl-activating enzyme (AAE) consensus motif; other site
859656001724	putative AMP binding site [chemical binding]; other site
859656001725	putative active site [active]
859656001726	putative CoA binding site [chemical binding]; other site
859656001727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656001728	metabolite-proton symporter; Region: 2A0106; TIGR00883
859656001729	putative substrate translocation pore; other site
859656001730	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656001731	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656001732	trimer interface [polypeptide binding]; other site
859656001733	eyelet of channel; other site
859656001734	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
859656001735	diiron binding motif [ion binding]; other site
859656001736	cell division protein MraZ; Reviewed; Region: PRK00326
859656001737	MraZ protein; Region: MraZ; pfam02381
859656001738	MraZ protein; Region: MraZ; pfam02381
859656001739	MraW methylase family; Region: Methyltransf_5; cl17771
859656001740	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
859656001741	Cell division protein FtsL; Region: FtsL; cl11433
859656001742	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
859656001743	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
859656001744	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
859656001745	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
859656001746	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859656001747	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859656001748	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859656001749	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
859656001750	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859656001751	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859656001752	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859656001753	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
859656001754	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
859656001755	Mg++ binding site [ion binding]; other site
859656001756	putative catalytic motif [active]
859656001757	putative substrate binding site [chemical binding]; other site
859656001758	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
859656001759	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859656001760	cell division protein FtsW; Region: ftsW; TIGR02614
859656001761	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
859656001762	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
859656001763	active site
859656001764	homodimer interface [polypeptide binding]; other site
859656001765	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
859656001766	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859656001767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859656001768	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859656001769	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
859656001770	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
859656001771	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859656001772	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
859656001773	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
859656001774	Cell division protein FtsQ; Region: FtsQ; pfam03799
859656001775	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
859656001776	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
859656001777	nucleotide binding site [chemical binding]; other site
859656001778	Cell division protein FtsA; Region: FtsA; pfam14450
859656001779	cell division protein FtsZ; Validated; Region: PRK09330
859656001780	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
859656001781	nucleotide binding site [chemical binding]; other site
859656001782	SulA interaction site; other site
859656001783	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
859656001784	catalytic triad [active]
859656001785	dimer interface [polypeptide binding]; other site
859656001786	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
859656001787	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
859656001788	Protein of unknown function (DUF721); Region: DUF721; cl02324
859656001789	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
859656001790	Peptidase family M23; Region: Peptidase_M23; pfam01551
859656001791	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
859656001792	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
859656001793	SEC-C motif; Region: SEC-C; pfam02810
859656001794	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
859656001795	heterotetramer interface [polypeptide binding]; other site
859656001796	active site pocket [active]
859656001797	cleavage site
859656001798	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
859656001799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656001800	Walker A motif; other site
859656001801	ATP binding site [chemical binding]; other site
859656001802	Walker B motif; other site
859656001803	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
859656001804	active site
859656001805	8-oxo-dGMP binding site [chemical binding]; other site
859656001806	nudix motif; other site
859656001807	metal binding site [ion binding]; metal-binding site
859656001808	Domain of unknown function (DUF329); Region: DUF329; pfam03884
859656001809	hypothetical protein; Provisional; Region: PRK05287
859656001810	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
859656001811	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
859656001812	CoA-binding site [chemical binding]; other site
859656001813	ATP-binding [chemical binding]; other site
859656001814	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
859656001815	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
859656001816	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
859656001817	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
859656001818	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656001819	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656001820	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
859656001821	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
859656001822	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859656001823	Walker A motif; other site
859656001824	ATP binding site [chemical binding]; other site
859656001825	Walker B motif; other site
859656001826	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
859656001827	Domain of unknown function DUF21; Region: DUF21; pfam01595
859656001828	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859656001829	Transporter associated domain; Region: CorC_HlyC; smart01091
859656001830	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
859656001831	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
859656001832	substrate binding pocket [chemical binding]; other site
859656001833	chain length determination region; other site
859656001834	substrate-Mg2+ binding site; other site
859656001835	catalytic residues [active]
859656001836	aspartate-rich region 1; other site
859656001837	active site lid residues [active]
859656001838	aspartate-rich region 2; other site
859656001839	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
859656001840	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
859656001841	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
859656001842	GTPase CgtA; Reviewed; Region: obgE; PRK12299
859656001843	GTP1/OBG; Region: GTP1_OBG; pfam01018
859656001844	Obg GTPase; Region: Obg; cd01898
859656001845	G1 box; other site
859656001846	GTP/Mg2+ binding site [chemical binding]; other site
859656001847	Switch I region; other site
859656001848	G2 box; other site
859656001849	G3 box; other site
859656001850	Switch II region; other site
859656001851	G4 box; other site
859656001852	G5 box; other site
859656001853	gamma-glutamyl kinase; Provisional; Region: PRK05429
859656001854	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
859656001855	nucleotide binding site [chemical binding]; other site
859656001856	homotetrameric interface [polypeptide binding]; other site
859656001857	putative phosphate binding site [ion binding]; other site
859656001858	putative allosteric binding site; other site
859656001859	PUA domain; Region: PUA; pfam01472
859656001860	CNP1-like family; Region: CNP1; pfam08750
859656001861	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
859656001862	putative active site [active]
859656001863	Ap4A binding site [chemical binding]; other site
859656001864	nudix motif; other site
859656001865	putative metal binding site [ion binding]; other site
859656001866	prolyl-tRNA synthetase; Provisional; Region: PRK09194
859656001867	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
859656001868	dimer interface [polypeptide binding]; other site
859656001869	motif 1; other site
859656001870	active site
859656001871	motif 2; other site
859656001872	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
859656001873	putative deacylase active site [active]
859656001874	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
859656001875	active site
859656001876	motif 3; other site
859656001877	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
859656001878	anticodon binding site; other site
859656001879	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656001880	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656001881	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656001882	catalytic residue [active]
859656001883	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
859656001884	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
859656001885	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656001886	active site
859656001887	signal recognition particle protein; Provisional; Region: PRK10867
859656001888	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
859656001889	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
859656001890	P loop; other site
859656001891	GTP binding site [chemical binding]; other site
859656001892	Signal peptide binding domain; Region: SRP_SPB; pfam02978
859656001893	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
859656001894	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
859656001895	putative active site [active]
859656001896	heme pocket [chemical binding]; other site
859656001897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656001898	dimer interface [polypeptide binding]; other site
859656001899	phosphorylation site [posttranslational modification]
859656001900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656001901	ATP binding site [chemical binding]; other site
859656001902	Mg2+ binding site [ion binding]; other site
859656001903	G-X-G motif; other site
859656001904	Response regulator receiver domain; Region: Response_reg; pfam00072
859656001905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656001906	active site
859656001907	phosphorylation site [posttranslational modification]
859656001908	intermolecular recognition site; other site
859656001909	dimerization interface [polypeptide binding]; other site
859656001910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656001911	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
859656001912	Walker A motif; other site
859656001913	ATP binding site [chemical binding]; other site
859656001914	Walker B motif; other site
859656001915	arginine finger; other site
859656001916	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656001917	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
859656001918	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
859656001919	amidase catalytic site [active]
859656001920	Zn binding residues [ion binding]; other site
859656001921	substrate binding site [chemical binding]; other site
859656001922	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
859656001923	ATP cone domain; Region: ATP-cone; pfam03477
859656001924	Class I ribonucleotide reductase; Region: RNR_I; cd01679
859656001925	active site
859656001926	dimer interface [polypeptide binding]; other site
859656001927	catalytic residues [active]
859656001928	effector binding site; other site
859656001929	R2 peptide binding site; other site
859656001930	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
859656001931	dimer interface [polypeptide binding]; other site
859656001932	putative radical transfer pathway; other site
859656001933	diiron center [ion binding]; other site
859656001934	tyrosyl radical; other site
859656001935	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
859656001936	putative active site [active]
859656001937	Zn binding site [ion binding]; other site
859656001938	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
859656001939	EamA-like transporter family; Region: EamA; pfam00892
859656001940	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656001941	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
859656001942	AsnC family; Region: AsnC_trans_reg; pfam01037
859656001943	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
859656001944	Cache domain; Region: Cache_2; pfam08269
859656001945	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656001946	dimer interface [polypeptide binding]; other site
859656001947	putative CheW interface [polypeptide binding]; other site
859656001948	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
859656001949	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
859656001950	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859656001951	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
859656001952	substrate binding site [chemical binding]; other site
859656001953	ATP binding site [chemical binding]; other site
859656001954	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
859656001955	dimer interface [polypeptide binding]; other site
859656001956	catalytic triad [active]
859656001957	peroxidatic and resolving cysteines [active]
859656001958	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
859656001959	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
859656001960	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
859656001961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656001962	S-adenosylmethionine binding site [chemical binding]; other site
859656001963	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
859656001964	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859656001965	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
859656001966	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
859656001967	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
859656001968	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
859656001969	carboxyltransferase (CT) interaction site; other site
859656001970	biotinylation site [posttranslational modification]; other site
859656001971	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
859656001972	Dehydroquinase class II; Region: DHquinase_II; pfam01220
859656001973	trimer interface [polypeptide binding]; other site
859656001974	active site
859656001975	dimer interface [polypeptide binding]; other site
859656001976	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859656001977	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656001978	catalytic residues [active]
859656001979	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
859656001980	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
859656001981	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859656001982	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859656001983	Predicted esterase [General function prediction only]; Region: COG3150
859656001984	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656001985	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
859656001986	Exoribonuclease R [Transcription]; Region: VacB; COG0557
859656001987	RNB domain; Region: RNB; pfam00773
859656001988	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
859656001989	TonB C terminal; Region: TonB_2; pfam13103
859656001990	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
859656001991	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
859656001992	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
859656001993	shikimate binding site; other site
859656001994	NAD(P) binding site [chemical binding]; other site
859656001995	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
859656001996	monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070
859656001997	Pectate lyase; Region: Pectate_lyase; pfam03211
859656001998	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
859656001999	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
859656002000	Cl binding site [ion binding]; other site
859656002001	oligomer interface [polypeptide binding]; other site
859656002002	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
859656002003	active site
859656002004	dimer interface [polypeptide binding]; other site
859656002005	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
859656002006	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
859656002007	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
859656002008	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
859656002009	tetramer interfaces [polypeptide binding]; other site
859656002010	binuclear metal-binding site [ion binding]; other site
859656002011	thiamine monophosphate kinase; Provisional; Region: PRK05731
859656002012	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
859656002013	ATP binding site [chemical binding]; other site
859656002014	dimerization interface [polypeptide binding]; other site
859656002015	malic enzyme; Reviewed; Region: PRK12862
859656002016	Malic enzyme, N-terminal domain; Region: malic; pfam00390
859656002017	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
859656002018	putative NAD(P) binding site [chemical binding]; other site
859656002019	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
859656002020	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
859656002021	active site
859656002022	barstar interaction site; other site
859656002023	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
859656002024	putative RNAase interaction site [polypeptide binding]; other site
859656002025	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
859656002026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
859656002027	RNA methyltransferase, RsmE family; Region: TIGR00046
859656002028	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
859656002029	putative dimer interface [polypeptide binding]; other site
859656002030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656002031	transketolase; Reviewed; Region: PRK12753
859656002032	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
859656002033	TPP-binding site [chemical binding]; other site
859656002034	dimer interface [polypeptide binding]; other site
859656002035	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
859656002036	PYR/PP interface [polypeptide binding]; other site
859656002037	dimer interface [polypeptide binding]; other site
859656002038	TPP binding site [chemical binding]; other site
859656002039	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
859656002040	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
859656002041	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
859656002042	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
859656002043	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656002044	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002045	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
859656002046	putative substrate binding pocket [chemical binding]; other site
859656002047	putative dimerization interface [polypeptide binding]; other site
859656002048	ferric uptake regulator; Provisional; Region: fur; PRK09462
859656002049	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
859656002050	metal binding site 2 [ion binding]; metal-binding site
859656002051	putative DNA binding helix; other site
859656002052	metal binding site 1 [ion binding]; metal-binding site
859656002053	dimer interface [polypeptide binding]; other site
859656002054	structural Zn2+ binding site [ion binding]; other site
859656002055	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
859656002056	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
859656002057	dihydrodipicolinate reductase; Provisional; Region: PRK00048
859656002058	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
859656002059	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
859656002060	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
859656002061	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
859656002062	HIGH motif; other site
859656002063	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
859656002064	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656002065	active site
859656002066	KMSKS motif; other site
859656002067	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
859656002068	tRNA binding surface [nucleotide binding]; other site
859656002069	Lipopolysaccharide-assembly; Region: LptE; cl01125
859656002070	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
859656002071	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
859656002072	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
859656002073	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
859656002074	putative catalytic cysteine [active]
859656002075	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
859656002076	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
859656002077	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
859656002078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859656002079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859656002080	Response regulator receiver domain; Region: Response_reg; pfam00072
859656002081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656002082	active site
859656002083	phosphorylation site [posttranslational modification]
859656002084	intermolecular recognition site; other site
859656002085	dimerization interface [polypeptide binding]; other site
859656002086	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656002087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656002088	active site
859656002089	phosphorylation site [posttranslational modification]
859656002090	intermolecular recognition site; other site
859656002091	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656002092	dimerization interface [polypeptide binding]; other site
859656002093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656002094	dimer interface [polypeptide binding]; other site
859656002095	phosphorylation site [posttranslational modification]
859656002096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656002097	ATP binding site [chemical binding]; other site
859656002098	Mg2+ binding site [ion binding]; other site
859656002099	G-X-G motif; other site
859656002100	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656002101	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656002102	dimer interface [polypeptide binding]; other site
859656002103	phosphorylation site [posttranslational modification]
859656002104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656002105	ATP binding site [chemical binding]; other site
859656002106	Mg2+ binding site [ion binding]; other site
859656002107	G-X-G motif; other site
859656002108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656002109	S-adenosylmethionine binding site [chemical binding]; other site
859656002110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656002111	active site
859656002112	phosphorylation site [posttranslational modification]
859656002113	intermolecular recognition site; other site
859656002114	dimerization interface [polypeptide binding]; other site
859656002115	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
859656002116	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
859656002117	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
859656002118	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
859656002119	tetramerization interface [polypeptide binding]; other site
859656002120	active site
859656002121	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
859656002122	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
859656002123	ligand binding site [chemical binding]; other site
859656002124	homodimer interface [polypeptide binding]; other site
859656002125	NAD(P) binding site [chemical binding]; other site
859656002126	trimer interface B [polypeptide binding]; other site
859656002127	trimer interface A [polypeptide binding]; other site
859656002128	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859656002129	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656002130	N-terminal plug; other site
859656002131	ligand-binding site [chemical binding]; other site
859656002132	Predicted membrane protein [Function unknown]; Region: COG3503
859656002133	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859656002134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656002135	putative substrate translocation pore; other site
859656002136	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
859656002137	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656002138	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656002139	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859656002140	MarR family; Region: MarR_2; cl17246
859656002141	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
859656002142	nudix motif; other site
859656002143	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
859656002144	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
859656002145	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
859656002146	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
859656002147	active site
859656002148	FMN binding site [chemical binding]; other site
859656002149	substrate binding site [chemical binding]; other site
859656002150	3Fe-4S cluster binding site [ion binding]; other site
859656002151	putative glutathione S-transferase; Provisional; Region: PRK10357
859656002152	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
859656002153	putative C-terminal domain interface [polypeptide binding]; other site
859656002154	putative GSH binding site (G-site) [chemical binding]; other site
859656002155	putative dimer interface [polypeptide binding]; other site
859656002156	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
859656002157	dimer interface [polypeptide binding]; other site
859656002158	N-terminal domain interface [polypeptide binding]; other site
859656002159	putative substrate binding pocket (H-site) [chemical binding]; other site
859656002160	adenylosuccinate lyase; Provisional; Region: PRK09285
859656002161	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
859656002162	tetramer interface [polypeptide binding]; other site
859656002163	active site
859656002164	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
859656002165	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859656002166	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859656002167	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
859656002168	Protein export membrane protein; Region: SecD_SecF; pfam02355
859656002169	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
859656002170	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
859656002171	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
859656002172	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
859656002173	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
859656002174	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
859656002175	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
859656002176	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
859656002177	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
859656002178	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
859656002179	generic binding surface II; other site
859656002180	ssDNA binding site; other site
859656002181	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656002182	ATP binding site [chemical binding]; other site
859656002183	putative Mg++ binding site [ion binding]; other site
859656002184	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656002185	nucleotide binding region [chemical binding]; other site
859656002186	ATP-binding site [chemical binding]; other site
859656002187	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
859656002188	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
859656002189	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
859656002190	dimer interface [polypeptide binding]; other site
859656002191	active site
859656002192	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656002193	substrate binding site [chemical binding]; other site
859656002194	catalytic residue [active]
859656002195	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656002196	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002197	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656002198	dimerization interface [polypeptide binding]; other site
859656002199	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656002200	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
859656002201	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656002202	catalytic residue [active]
859656002203	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
859656002204	allantoate amidohydrolase; Reviewed; Region: PRK12890
859656002205	active site
859656002206	metal binding site [ion binding]; metal-binding site
859656002207	dimer interface [polypeptide binding]; other site
859656002208	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656002209	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656002210	putative DNA binding site [nucleotide binding]; other site
859656002211	putative Zn2+ binding site [ion binding]; other site
859656002212	AsnC family; Region: AsnC_trans_reg; pfam01037
859656002213	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
859656002214	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
859656002215	metal binding site [ion binding]; metal-binding site
859656002216	putative dimer interface [polypeptide binding]; other site
859656002217	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859656002218	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656002219	DNA-binding site [nucleotide binding]; DNA binding site
859656002220	FCD domain; Region: FCD; pfam07729
859656002221	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859656002222	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859656002223	benzoate transport; Region: 2A0115; TIGR00895
859656002224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656002225	putative substrate translocation pore; other site
859656002226	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859656002227	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
859656002228	inhibitor site; inhibition site
859656002229	active site
859656002230	dimer interface [polypeptide binding]; other site
859656002231	catalytic residue [active]
859656002232	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656002233	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
859656002234	NAD(P) binding site [chemical binding]; other site
859656002235	catalytic residues [active]
859656002236	aromatic amino acid exporter; Provisional; Region: PRK11689
859656002237	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656002238	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656002239	trimer interface [polypeptide binding]; other site
859656002240	eyelet of channel; other site
859656002241	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
859656002242	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656002243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002244	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
859656002245	dimerization interface [polypeptide binding]; other site
859656002246	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
859656002247	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
859656002248	dimerization interface [polypeptide binding]; other site
859656002249	DPS ferroxidase diiron center [ion binding]; other site
859656002250	ion pore; other site
859656002251	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
859656002252	UbiA prenyltransferase family; Region: UbiA; pfam01040
859656002253	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
859656002254	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
859656002255	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
859656002256	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656002257	catalytic residue [active]
859656002258	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
859656002259	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
859656002260	Walker A motif; other site
859656002261	ATP binding site [chemical binding]; other site
859656002262	Walker B motif; other site
859656002263	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
859656002264	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
859656002265	Walker A motif; other site
859656002266	ATP binding site [chemical binding]; other site
859656002267	Walker B motif; other site
859656002268	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859656002269	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
859656002270	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859656002271	Type II transport protein GspH; Region: GspH; pfam12019
859656002272	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
859656002273	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859656002274	PilX N-terminal; Region: PilX_N; pfam14341
859656002275	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859656002276	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
859656002277	catalytic residues [active]
859656002278	dimer interface [polypeptide binding]; other site
859656002279	Predicted transcriptional regulator [Transcription]; Region: COG2378
859656002280	HTH domain; Region: HTH_11; pfam08279
859656002281	WYL domain; Region: WYL; pfam13280
859656002282	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
859656002283	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
859656002284	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656002285	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
859656002286	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
859656002287	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
859656002288	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859656002289	Cysteine-rich domain; Region: CCG; pfam02754
859656002290	Cysteine-rich domain; Region: CCG; pfam02754
859656002291	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
859656002292	FAD binding domain; Region: FAD_binding_4; pfam01565
859656002293	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
859656002294	FAD binding domain; Region: FAD_binding_4; pfam01565
859656002295	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859656002296	FAD binding domain; Region: FAD_binding_4; pfam01565
859656002297	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
859656002298	mechanosensitive channel MscS; Provisional; Region: PRK10334
859656002299	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859656002300	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656002301	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656002302	non-specific DNA binding site [nucleotide binding]; other site
859656002303	salt bridge; other site
859656002304	sequence-specific DNA binding site [nucleotide binding]; other site
859656002305	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
859656002306	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
859656002307	protease TldD; Provisional; Region: tldD; PRK10735
859656002308	Predicted amidohydrolase [General function prediction only]; Region: COG0388
859656002309	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
859656002310	putative active site [active]
859656002311	catalytic triad [active]
859656002312	dimer interface [polypeptide binding]; other site
859656002313	Predicted membrane protein [Function unknown]; Region: COG3164
859656002314	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
859656002315	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
859656002316	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
859656002317	metal binding triad; other site
859656002318	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
859656002319	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
859656002320	metal binding triad; other site
859656002321	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
859656002322	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
859656002323	active site
859656002324	catalytic triad [active]
859656002325	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
859656002326	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
859656002327	active site
859656002328	catalytic triad [active]
859656002329	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
859656002330	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
859656002331	Walker A/P-loop; other site
859656002332	ATP binding site [chemical binding]; other site
859656002333	Q-loop/lid; other site
859656002334	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
859656002335	ABC transporter signature motif; other site
859656002336	Walker B; other site
859656002337	D-loop; other site
859656002338	H-loop/switch region; other site
859656002339	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
859656002340	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
859656002341	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
859656002342	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
859656002343	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
859656002344	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656002345	DNA-binding site [nucleotide binding]; DNA binding site
859656002346	UTRA domain; Region: UTRA; pfam07702
859656002347	urocanate hydratase; Provisional; Region: PRK05414
859656002348	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
859656002349	active sites [active]
859656002350	tetramer interface [polypeptide binding]; other site
859656002351	formimidoylglutamase; Provisional; Region: PRK13775
859656002352	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
859656002353	putative active site [active]
859656002354	putative metal binding site [ion binding]; other site
859656002355	imidazolonepropionase; Validated; Region: PRK09356
859656002356	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
859656002357	active site
859656002358	ferrochelatase; Reviewed; Region: hemH; PRK00035
859656002359	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
859656002360	C-terminal domain interface [polypeptide binding]; other site
859656002361	active site
859656002362	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
859656002363	active site
859656002364	N-terminal domain interface [polypeptide binding]; other site
859656002365	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656002366	RNA binding surface [nucleotide binding]; other site
859656002367	GrpE; Region: GrpE; pfam01025
859656002368	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
859656002369	dimer interface [polypeptide binding]; other site
859656002370	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
859656002371	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859656002372	catalytic residues [active]
859656002373	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
859656002374	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
859656002375	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
859656002376	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
859656002377	nucleotide binding site [chemical binding]; other site
859656002378	chaperone protein DnaJ; Provisional; Region: PRK10767
859656002379	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
859656002380	HSP70 interaction site [polypeptide binding]; other site
859656002381	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
859656002382	Zn binding sites [ion binding]; other site
859656002383	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
859656002384	dimer interface [polypeptide binding]; other site
859656002385	chorismate binding enzyme; Region: Chorismate_bind; cl10555
859656002386	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
859656002387	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
859656002388	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
859656002389	homodimer interface [polypeptide binding]; other site
859656002390	substrate-cofactor binding pocket; other site
859656002391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656002392	catalytic residue [active]
859656002393	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
859656002394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656002395	Walker A/P-loop; other site
859656002396	ATP binding site [chemical binding]; other site
859656002397	Q-loop/lid; other site
859656002398	ABC transporter signature motif; other site
859656002399	Walker B; other site
859656002400	D-loop; other site
859656002401	H-loop/switch region; other site
859656002402	ABC-type tungstate transport system, periplasmic component [Coenzyme metabolism]; Region: TupA; COG4662
859656002403	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
859656002404	oligomerization interface [polypeptide binding]; other site
859656002405	active site
859656002406	metal binding site [ion binding]; metal-binding site
859656002407	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
859656002408	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
859656002409	Substrate-binding site [chemical binding]; other site
859656002410	Substrate specificity [chemical binding]; other site
859656002411	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
859656002412	catalytic center binding site [active]
859656002413	ATP binding site [chemical binding]; other site
859656002414	poly(A) polymerase; Region: pcnB; TIGR01942
859656002415	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
859656002416	active site
859656002417	NTP binding site [chemical binding]; other site
859656002418	metal binding triad [ion binding]; metal-binding site
859656002419	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
859656002420	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
859656002421	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
859656002422	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
859656002423	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
859656002424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656002425	Walker A motif; other site
859656002426	ATP binding site [chemical binding]; other site
859656002427	Walker B motif; other site
859656002428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859656002429	arginine finger; other site
859656002430	Domain of unknown function DUF20; Region: UPF0118; pfam01594
859656002431	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
859656002432	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
859656002433	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
859656002434	dimerization interface [polypeptide binding]; other site
859656002435	putative ATP binding site [chemical binding]; other site
859656002436	Evidence 4 : Homologs of previously reported genes of unknown function
859656002437	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
859656002438	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
859656002439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656002440	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
859656002441	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
859656002442	DNA binding site [nucleotide binding]
859656002443	active site
859656002444	Evidence 2b : Function of strongly homologous gene; PubMedId : 8376346; Product type e : enzyme
859656002445	Evidence 2b : Function of strongly homologous gene; PubMedId : 8376346; Product type e : enzyme
859656002446	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
859656002447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
859656002448	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656002449	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
859656002450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656002451	Coenzyme A binding pocket [chemical binding]; other site
859656002452	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
859656002453	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
859656002454	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
859656002455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656002456	ATP binding site [chemical binding]; other site
859656002457	Mg2+ binding site [ion binding]; other site
859656002458	G-X-G motif; other site
859656002459	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
859656002460	ATP binding site [chemical binding]; other site
859656002461	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
859656002462	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
859656002463	mce related protein; Region: MCE; pfam02470
859656002464	mce related protein; Region: MCE; pfam02470
859656002465	mce related protein; Region: MCE; pfam02470
859656002466	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
859656002467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656002468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656002469	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
859656002470	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
859656002471	Uncharacterized conserved protein [Function unknown]; Region: COG2912
859656002472	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
859656002473	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
859656002474	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
859656002475	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
859656002476	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
859656002477	ornithine carbamoyltransferase; Provisional; Region: PRK00779
859656002478	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
859656002479	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
859656002480	argininosuccinate synthase; Validated; Region: PRK05370
859656002481	argininosuccinate synthase; Provisional; Region: PRK13820
859656002482	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
859656002483	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859656002484	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859656002485	active site
859656002486	nucleophile elbow; other site
859656002487	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
859656002488	FAD binding domain; Region: FAD_binding_4; pfam01565
859656002489	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
859656002490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
859656002491	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
859656002492	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
859656002493	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
859656002494	putative deacylase active site [active]
859656002495	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
859656002496	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859656002497	active site
859656002498	DNA binding site [nucleotide binding]
859656002499	Int/Topo IB signature motif; other site
859656002500	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
859656002501	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
859656002502	DNA binding site [nucleotide binding]
859656002503	active site
859656002504	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
859656002505	Evidence 4 : Homologs of previously reported genes of unknown function
859656002506	epoxyqueuosine reductase; Region: TIGR00276
859656002507	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
859656002508	4Fe-4S binding domain; Region: Fer4_6; pfam12837
859656002509	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
859656002510	AMIN domain; Region: AMIN; pfam11741
859656002511	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
859656002512	active site
859656002513	metal binding site [ion binding]; metal-binding site
859656002514	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
859656002515	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
859656002516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656002517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002518	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
859656002519	putative dimerization interface [polypeptide binding]; other site
859656002520	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
859656002521	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
859656002522	NAD binding site [chemical binding]; other site
859656002523	homodimer interface [polypeptide binding]; other site
859656002524	homotetramer interface [polypeptide binding]; other site
859656002525	active site
859656002526	adenylate kinase; Reviewed; Region: adk; PRK00279
859656002527	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
859656002528	AMP-binding site [chemical binding]; other site
859656002529	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
859656002530	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
859656002531	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
859656002532	Ligand binding site; other site
859656002533	oligomer interface; other site
859656002534	Uncharacterized conserved protein [Function unknown]; Region: COG2835
859656002535	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
859656002536	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
859656002537	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
859656002538	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
859656002539	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
859656002540	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
859656002541	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
859656002542	generic binding surface II; other site
859656002543	generic binding surface I; other site
859656002544	superoxide dismutase; Provisional; Region: PRK10543
859656002545	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
859656002546	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
859656002547	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
859656002548	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859656002549	NAD(P) binding site [chemical binding]; other site
859656002550	homotetramer interface [polypeptide binding]; other site
859656002551	homodimer interface [polypeptide binding]; other site
859656002552	active site
859656002553	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
859656002554	Peptidase family M50; Region: Peptidase_M50; pfam02163
859656002555	active site
859656002556	putative substrate binding region [chemical binding]; other site
859656002557	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
859656002558	HutD; Region: HutD; cl01532
859656002559	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859656002560	IHF dimer interface [polypeptide binding]; other site
859656002561	IHF - DNA interface [nucleotide binding]; other site
859656002562	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
859656002563	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
859656002564	NAD binding site [chemical binding]; other site
859656002565	active site
859656002566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656002567	metabolite-proton symporter; Region: 2A0106; TIGR00883
859656002568	putative substrate translocation pore; other site
859656002569	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
859656002570	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
859656002571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656002572	dimer interface [polypeptide binding]; other site
859656002573	conserved gate region; other site
859656002574	putative PBP binding loops; other site
859656002575	ABC-ATPase subunit interface; other site
859656002576	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
859656002577	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
859656002578	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656002579	Zn2+ binding site [ion binding]; other site
859656002580	Mg2+ binding site [ion binding]; other site
859656002581	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656002582	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656002583	substrate binding pocket [chemical binding]; other site
859656002584	membrane-bound complex binding site; other site
859656002585	hinge residues; other site
859656002586	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
859656002587	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
859656002588	HipA N-terminal domain; Region: Couple_hipA; cl11853
859656002589	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859656002590	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859656002591	EamA-like transporter family; Region: EamA; pfam00892
859656002592	EamA-like transporter family; Region: EamA; pfam00892
859656002593	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656002594	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
859656002595	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
859656002596	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
859656002597	DNA binding site [nucleotide binding]
859656002598	active site
859656002599	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
859656002600	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
859656002601	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656002602	AlkA N-terminal domain; Region: AlkA_N; pfam06029
859656002603	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
859656002604	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
859656002605	minor groove reading motif; other site
859656002606	helix-hairpin-helix signature motif; other site
859656002607	substrate binding pocket [chemical binding]; other site
859656002608	active site
859656002609	glucose-1-dehydrogenase; Provisional; Region: PRK06947
859656002610	classical (c) SDRs; Region: SDR_c; cd05233
859656002611	NAD(P) binding site [chemical binding]; other site
859656002612	active site
859656002613	Predicted metalloprotease [General function prediction only]; Region: COG2321
859656002614	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
859656002615	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859656002616	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
859656002617	dimer interface [polypeptide binding]; other site
859656002618	active site
859656002619	catalytic residue [active]
859656002620	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
859656002621	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
859656002622	Predicted membrane protein [Function unknown]; Region: COG2259
859656002623	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859656002624	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656002625	putative substrate translocation pore; other site
859656002626	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656002627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002628	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656002629	putative effector binding pocket; other site
859656002630	dimerization interface [polypeptide binding]; other site
859656002631	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
859656002632	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002633	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656002634	dimerization interface [polypeptide binding]; other site
859656002635	Predicted periplasmic protein [General function prediction only]; Region: COG3895
859656002636	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
859656002637	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
859656002638	Uncharacterized conserved protein [Function unknown]; Region: COG1430
859656002639	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
859656002640	Cytochrome c; Region: Cytochrom_C; pfam00034
859656002641	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859656002642	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656002643	active site
859656002644	metal binding site [ion binding]; metal-binding site
859656002645	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859656002646	isocitrate dehydrogenase; Validated; Region: PRK07362
859656002647	isocitrate dehydrogenase; Reviewed; Region: PRK07006
859656002648	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656002649	RHS Repeat; Region: RHS_repeat; pfam05593
859656002650	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859656002651	RHS Repeat; Region: RHS_repeat; pfam05593
859656002652	RHS Repeat; Region: RHS_repeat; cl11982
859656002653	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859656002654	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859656002655	RHS Repeat; Region: RHS_repeat; pfam05593
859656002656	Evidence 4 : Homologs of previously reported genes of unknown function
859656002657	Evidence 4 : Homologs of previously reported genes of unknown function
859656002658	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
859656002659	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859656002660	DNA-binding site [nucleotide binding]; DNA binding site
859656002661	RNA-binding motif; other site
859656002662	Uncharacterized conserved protein [Function unknown]; Region: COG2127
859656002663	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
859656002664	Clp amino terminal domain; Region: Clp_N; pfam02861
859656002665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656002666	Walker A motif; other site
859656002667	ATP binding site [chemical binding]; other site
859656002668	Walker B motif; other site
859656002669	arginine finger; other site
859656002670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656002671	Walker A motif; other site
859656002672	ATP binding site [chemical binding]; other site
859656002673	Walker B motif; other site
859656002674	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
859656002675	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12369928; Product type e : enzyme
859656002676	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
859656002677	active site
859656002678	catalytic residues [active]
859656002679	DNA binding site [nucleotide binding]
859656002680	Int/Topo IB signature motif; other site
859656002681	Protein of unknown function (DUF1250); Region: DUF1250; cl11485
859656002682	Evidence 4 : Homologs of previously reported genes of unknown function
859656002683	P-loop containing region of AAA domain; Region: AAA_29; cl17516
859656002684	AAA domain; Region: AAA_27; pfam13514
859656002685	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
859656002686	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
859656002687	active site
859656002688	metal binding site [ion binding]; metal-binding site
859656002689	DNA binding site [nucleotide binding]
859656002690	AAA domain; Region: AAA_13; pfam13166
859656002691	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656002692	ABC transporter signature motif; other site
859656002693	Walker B; other site
859656002694	D-loop; other site
859656002695	H-loop/switch region; other site
859656002696	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
859656002697	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
859656002698	AAA domain; Region: AAA_11; pfam13086
859656002699	Part of AAA domain; Region: AAA_19; pfam13245
859656002700	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
859656002701	AAA domain; Region: AAA_12; pfam13087
859656002702	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
859656002703	putative active site [active]
859656002704	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
859656002705	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
859656002706	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
859656002707	H-NS histone family; Region: Histone_HNS; pfam00816
859656002708	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859656002709	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
859656002710	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656002711	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656002712	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
859656002713	Evidence 2b : Function of strongly homologous gene; Product type cp : cell process
859656002714	Evidence 4 : Homologs of previously reported genes of unknown function
859656002715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656002716	non-specific DNA binding site [nucleotide binding]; other site
859656002717	salt bridge; other site
859656002718	sequence-specific DNA binding site [nucleotide binding]; other site
859656002719	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
859656002720	trimer interface [polypeptide binding]; other site
859656002721	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
859656002722	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
859656002723	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
859656002724	Flavoprotein; Region: Flavoprotein; pfam02441
859656002725	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
859656002726	Uncharacterized conserved protein [Function unknown]; Region: COG1434
859656002727	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
859656002728	putative active site [active]
859656002729	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
859656002730	lipoprotein signal peptidase; Provisional; Region: PRK14787
859656002731	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
859656002732	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656002733	active site
859656002734	HIGH motif; other site
859656002735	nucleotide binding site [chemical binding]; other site
859656002736	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
859656002737	active site
859656002738	KMSKS motif; other site
859656002739	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
859656002740	tRNA binding surface [nucleotide binding]; other site
859656002741	anticodon binding site; other site
859656002742	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
859656002743	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
859656002744	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
859656002745	active site
859656002746	Riboflavin kinase; Region: Flavokinase; smart00904
859656002747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656002748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656002749	ATP binding site [chemical binding]; other site
859656002750	Mg2+ binding site [ion binding]; other site
859656002751	G-X-G motif; other site
859656002752	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656002753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656002754	active site
859656002755	phosphorylation site [posttranslational modification]
859656002756	intermolecular recognition site; other site
859656002757	dimerization interface [polypeptide binding]; other site
859656002758	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656002759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656002760	active site
859656002761	phosphorylation site [posttranslational modification]
859656002762	intermolecular recognition site; other site
859656002763	dimerization interface [polypeptide binding]; other site
859656002764	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656002765	DNA binding residues [nucleotide binding]
859656002766	dimerization interface [polypeptide binding]; other site
859656002767	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859656002768	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
859656002769	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
859656002770	active site
859656002771	cosubstrate binding site; other site
859656002772	substrate binding site [chemical binding]; other site
859656002773	catalytic site [active]
859656002774	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
859656002775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656002776	S-adenosylmethionine binding site [chemical binding]; other site
859656002777	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
859656002778	PLD-like domain; Region: PLDc_2; pfam13091
859656002779	putative active site [active]
859656002780	catalytic site [active]
859656002781	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
859656002782	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859656002783	Fatty acid desaturase; Region: FA_desaturase; pfam00487
859656002784	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
859656002785	Di-iron ligands [ion binding]; other site
859656002786	Transposase; Region: DDE_Tnp_ISL3; pfam01610
859656002787	quinolinate synthetase; Provisional; Region: PRK09375
859656002788	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
859656002789	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
859656002790	dimerization interface [polypeptide binding]; other site
859656002791	active site
859656002792	L-aspartate oxidase; Provisional; Region: PRK09077
859656002793	L-aspartate oxidase; Provisional; Region: PRK06175
859656002794	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
859656002795	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
859656002796	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
859656002797	hypothetical protein; Reviewed; Region: PRK00024
859656002798	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
859656002799	MPN+ (JAMM) motif; other site
859656002800	Zinc-binding site [ion binding]; other site
859656002801	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
859656002802	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859656002803	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
859656002804	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
859656002805	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656002806	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
859656002807	dimerization interface [polypeptide binding]; other site
859656002808	ligand binding site [chemical binding]; other site
859656002809	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656002810	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656002811	TM-ABC transporter signature motif; other site
859656002812	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656002813	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656002814	TM-ABC transporter signature motif; other site
859656002815	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859656002816	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656002817	Walker A/P-loop; other site
859656002818	ATP binding site [chemical binding]; other site
859656002819	Q-loop/lid; other site
859656002820	ABC transporter signature motif; other site
859656002821	Walker B; other site
859656002822	D-loop; other site
859656002823	H-loop/switch region; other site
859656002824	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859656002825	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656002826	Walker A/P-loop; other site
859656002827	ATP binding site [chemical binding]; other site
859656002828	Q-loop/lid; other site
859656002829	ABC transporter signature motif; other site
859656002830	Walker B; other site
859656002831	D-loop; other site
859656002832	H-loop/switch region; other site
859656002833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656002834	Coenzyme A binding pocket [chemical binding]; other site
859656002835	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
859656002836	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656002837	inhibitor-cofactor binding pocket; inhibition site
859656002838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656002839	catalytic residue [active]
859656002840	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
859656002841	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656002842	catalytic loop [active]
859656002843	iron binding site [ion binding]; other site
859656002844	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
859656002845	FAD binding pocket [chemical binding]; other site
859656002846	FAD binding motif [chemical binding]; other site
859656002847	phosphate binding motif [ion binding]; other site
859656002848	beta-alpha-beta structure motif; other site
859656002849	NAD binding pocket [chemical binding]; other site
859656002850	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859656002851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656002852	NAD(P) binding site [chemical binding]; other site
859656002853	active site
859656002854	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859656002855	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656002856	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656002857	metal binding site [ion binding]; metal-binding site
859656002858	active site
859656002859	I-site; other site
859656002860	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859656002861	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
859656002862	Cl- selectivity filter; other site
859656002863	Cl- binding residues [ion binding]; other site
859656002864	pore gating glutamate residue; other site
859656002865	dimer interface [polypeptide binding]; other site
859656002866	FOG: CBS domain [General function prediction only]; Region: COG0517
859656002867	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
859656002868	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859656002869	MarR family; Region: MarR_2; pfam12802
859656002870	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
859656002871	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
859656002872	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656002873	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
859656002874	putative ligand binding site [chemical binding]; other site
859656002875	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
859656002876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002877	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
859656002878	substrate binding site [chemical binding]; other site
859656002879	dimerization interface [polypeptide binding]; other site
859656002880	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859656002881	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
859656002882	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
859656002883	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
859656002884	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
859656002885	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
859656002886	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
859656002887	Active Sites [active]
859656002888	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
859656002889	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
859656002890	Active Sites [active]
859656002891	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
859656002892	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
859656002893	CysD dimerization site [polypeptide binding]; other site
859656002894	G1 box; other site
859656002895	putative GEF interaction site [polypeptide binding]; other site
859656002896	GTP/Mg2+ binding site [chemical binding]; other site
859656002897	Switch I region; other site
859656002898	G2 box; other site
859656002899	G3 box; other site
859656002900	Switch II region; other site
859656002901	G4 box; other site
859656002902	G5 box; other site
859656002903	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
859656002904	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
859656002905	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
859656002906	active site
859656002907	SAM binding site [chemical binding]; other site
859656002908	homodimer interface [polypeptide binding]; other site
859656002909	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
859656002910	putative substrate binding pocket [chemical binding]; other site
859656002911	trimer interface [polypeptide binding]; other site
859656002912	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
859656002913	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
859656002914	putative active site [active]
859656002915	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
859656002916	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
859656002917	Predicted permeases [General function prediction only]; Region: COG0795
859656002918	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
859656002919	multifunctional aminopeptidase A; Provisional; Region: PRK00913
859656002920	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
859656002921	interface (dimer of trimers) [polypeptide binding]; other site
859656002922	Substrate-binding/catalytic site; other site
859656002923	Zn-binding sites [ion binding]; other site
859656002924	DNA polymerase III subunit chi; Validated; Region: PRK05728
859656002925	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
859656002926	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
859656002927	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656002928	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
859656002929	putative dimerization interface [polypeptide binding]; other site
859656002930	putative substrate binding pocket [chemical binding]; other site
859656002931	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
859656002932	Protein of unknown function (DUF541); Region: SIMPL; cl01077
859656002933	Uncharacterized conserved protein [Function unknown]; Region: COG2968
859656002934	Uncharacterized conserved protein [Function unknown]; Region: COG2947
859656002935	Cell division protein ZapA; Region: ZapA; pfam05164
859656002936	Domain of unknown function (DUF1875); Region: DUF1875; pfam08961
859656002937	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
859656002938	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656002939	N-terminal plug; other site
859656002940	ligand-binding site [chemical binding]; other site
859656002941	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
859656002942	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
859656002943	dimer interface [polypeptide binding]; other site
859656002944	putative PBP binding regions; other site
859656002945	ABC-ATPase subunit  interface; other site
859656002946	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
859656002947	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
859656002948	Walker A/P-loop; other site
859656002949	ATP binding site [chemical binding]; other site
859656002950	Q-loop/lid; other site
859656002951	ABC transporter signature motif; other site
859656002952	Walker B; other site
859656002953	D-loop; other site
859656002954	H-loop/switch region; other site
859656002955	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
859656002956	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
859656002957	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
859656002958	putative dimer interface [polypeptide binding]; other site
859656002959	active site pocket [active]
859656002960	putative cataytic base [active]
859656002961	cobalamin synthase; Reviewed; Region: cobS; PRK00235
859656002962	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859656002963	catalytic core [active]
859656002964	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
859656002965	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
859656002966	cobalamin binding residues [chemical binding]; other site
859656002967	putative BtuC binding residues; other site
859656002968	dimer interface [polypeptide binding]; other site
859656002969	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
859656002970	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656002971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656002972	homodimer interface [polypeptide binding]; other site
859656002973	catalytic residue [active]
859656002974	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
859656002975	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
859656002976	homotrimer interface [polypeptide binding]; other site
859656002977	Walker A motif; other site
859656002978	GTP binding site [chemical binding]; other site
859656002979	Walker B motif; other site
859656002980	cobyric acid synthase; Provisional; Region: PRK00784
859656002981	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
859656002982	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
859656002983	catalytic triad [active]
859656002984	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
859656002985	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859656002986	P-loop; other site
859656002987	Magnesium ion binding site [ion binding]; other site
859656002988	pantoate--beta-alanine ligase; Region: panC; TIGR00018
859656002989	Pantoate-beta-alanine ligase; Region: PanC; cd00560
859656002990	active site
859656002991	ATP-binding site [chemical binding]; other site
859656002992	pantoate-binding site; other site
859656002993	HXXH motif; other site
859656002994	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
859656002995	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
859656002996	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
859656002997	Surface antigen; Region: Bac_surface_Ag; pfam01103
859656002998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
859656002999	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
859656003000	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
859656003001	Family of unknown function (DUF490); Region: DUF490; pfam04357
859656003002	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
859656003003	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
859656003004	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
859656003005	active site
859656003006	HIGH motif; other site
859656003007	KMSKS motif; other site
859656003008	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
859656003009	tRNA binding surface [nucleotide binding]; other site
859656003010	anticodon binding site; other site
859656003011	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
859656003012	dimer interface [polypeptide binding]; other site
859656003013	putative tRNA-binding site [nucleotide binding]; other site
859656003014	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859656003015	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859656003016	ligand binding site [chemical binding]; other site
859656003017	antiporter inner membrane protein; Provisional; Region: PRK11670
859656003018	Domain of unknown function DUF59; Region: DUF59; pfam01883
859656003019	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
859656003020	Walker A motif; other site
859656003021	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
859656003022	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
859656003023	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
859656003024	4Fe-4S binding domain; Region: Fer4; pfam00037
859656003025	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
859656003026	4Fe-4S binding domain; Region: Fer4; pfam00037
859656003027	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859656003028	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
859656003029	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
859656003030	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
859656003031	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859656003032	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
859656003033	[4Fe-4S] binding site [ion binding]; other site
859656003034	molybdopterin cofactor binding site; other site
859656003035	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859656003036	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859656003037	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
859656003038	molybdopterin cofactor binding site; other site
859656003039	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
859656003040	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
859656003041	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
859656003042	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
859656003043	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
859656003044	E-class dimer interface [polypeptide binding]; other site
859656003045	P-class dimer interface [polypeptide binding]; other site
859656003046	active site
859656003047	Cu2+ binding site [ion binding]; other site
859656003048	Zn2+ binding site [ion binding]; other site
859656003049	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
859656003050	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
859656003051	trimer interface [polypeptide binding]; other site
859656003052	active site
859656003053	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
859656003054	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
859656003055	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859656003056	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656003057	catalytic residue [active]
859656003058	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
859656003059	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
859656003060	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
859656003061	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
859656003062	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
859656003063	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
859656003064	CT1975-like protein; Region: Cas_CT1975; pfam09344
859656003065	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
859656003066	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
859656003067	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
859656003068	CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; Region: cas1_ECOLI; TIGR03638
859656003069	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
859656003070	argininosuccinate lyase; Provisional; Region: PRK00855
859656003071	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
859656003072	active sites [active]
859656003073	tetramer interface [polypeptide binding]; other site
859656003074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
859656003075	Anti-sigma-K factor rskA; Region: RskA; pfam10099
859656003076	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859656003077	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656003078	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656003079	DNA binding residues [nucleotide binding]
859656003080	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
859656003081	dinuclear metal binding motif [ion binding]; other site
859656003082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656003083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656003084	LysR substrate binding domain; Region: LysR_substrate; pfam03466
859656003085	dimerization interface [polypeptide binding]; other site
859656003086	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859656003087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656003088	putative substrate translocation pore; other site
859656003089	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
859656003090	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
859656003091	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
859656003092	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
859656003093	domain interfaces; other site
859656003094	active site
859656003095	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
859656003096	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
859656003097	active site
859656003098	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
859656003099	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
859656003100	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
859656003101	HemY protein N-terminus; Region: HemY_N; pfam07219
859656003102	Cytochrome b [Energy production and conversion]; Region: COG3658
859656003103	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
859656003104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656003105	D-galactonate transporter; Region: 2A0114; TIGR00893
859656003106	putative substrate translocation pore; other site
859656003107	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
859656003108	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
859656003109	putative NAD(P) binding site [chemical binding]; other site
859656003110	active site
859656003111	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656003112	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
859656003113	NAD(P) binding site [chemical binding]; other site
859656003114	catalytic residues [active]
859656003115	catalytic residues [active]
859656003116	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
859656003117	dimer interface [polypeptide binding]; other site
859656003118	substrate binding site [chemical binding]; other site
859656003119	metal binding sites [ion binding]; metal-binding site
859656003120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
859656003121	Protein of unknown function, DUF482; Region: DUF482; pfam04339
859656003122	NAD synthetase; Provisional; Region: PRK13981
859656003123	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
859656003124	multimer interface [polypeptide binding]; other site
859656003125	active site
859656003126	catalytic triad [active]
859656003127	protein interface 1 [polypeptide binding]; other site
859656003128	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
859656003129	homodimer interface [polypeptide binding]; other site
859656003130	NAD binding pocket [chemical binding]; other site
859656003131	ATP binding pocket [chemical binding]; other site
859656003132	Mg binding site [ion binding]; other site
859656003133	active-site loop [active]
859656003134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656003135	S-adenosylmethionine binding site [chemical binding]; other site
859656003136	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
859656003137	Nitrogen regulatory protein P-II; Region: P-II; smart00938
859656003138	Predicted membrane protein [Function unknown]; Region: COG2860
859656003139	UPF0126 domain; Region: UPF0126; pfam03458
859656003140	UPF0126 domain; Region: UPF0126; pfam03458
859656003141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
859656003142	Smr domain; Region: Smr; pfam01713
859656003143	thioredoxin reductase; Provisional; Region: PRK10262
859656003144	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859656003145	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656003146	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
859656003147	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
859656003148	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
859656003149	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
859656003150	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
859656003151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656003152	AAA domain; Region: AAA_22; pfam13401
859656003153	Walker A motif; other site
859656003154	ATP binding site [chemical binding]; other site
859656003155	Walker B motif; other site
859656003156	recombination factor protein RarA; Reviewed; Region: PRK13342
859656003157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656003158	Walker A motif; other site
859656003159	ATP binding site [chemical binding]; other site
859656003160	Walker B motif; other site
859656003161	arginine finger; other site
859656003162	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
859656003163	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656003164	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656003165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656003166	NAD(P) binding site [chemical binding]; other site
859656003167	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859656003168	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859656003169	HTH-like domain; Region: HTH_21; pfam13276
859656003170	Integrase core domain; Region: rve; pfam00665
859656003171	Integrase core domain; Region: rve_3; pfam13683
859656003172	Transposase; Region: HTH_Tnp_1; cl17663
859656003173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859656003174	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859656003175	DNA-binding interface [nucleotide binding]; DNA binding site
859656003176	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656003177	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656003178	seryl-tRNA synthetase; Provisional; Region: PRK05431
859656003179	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
859656003180	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
859656003181	dimer interface [polypeptide binding]; other site
859656003182	active site
859656003183	motif 1; other site
859656003184	motif 2; other site
859656003185	motif 3; other site
859656003186	Evidence 4 : Homologs of previously reported genes of unknown function
859656003187	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
859656003188	active site
859656003189	catalytic triad [active]
859656003190	calcium binding site [ion binding]; other site
859656003191	VirK protein; Region: VirK; pfam06903
859656003192	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
859656003193	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859656003194	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
859656003195	DNA binding residues [nucleotide binding]
859656003196	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859656003197	Domain of unknown function DUF21; Region: DUF21; pfam01595
859656003198	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
859656003199	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859656003200	Transporter associated domain; Region: CorC_HlyC; smart01091
859656003201	Uncharacterized conserved protein [Function unknown]; Region: COG3868
859656003202	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
859656003203	putative active site [active]
859656003204	Tetratricopeptide repeat; Region: TPR_15; pfam13429
859656003205	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
859656003206	GAF domain; Region: GAF_3; pfam13492
859656003207	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
859656003208	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
859656003209	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859656003210	Predicted membrane protein [Function unknown]; Region: COG4267
859656003211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
859656003212	MULE transposase domain; Region: MULE; pfam10551
859656003213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
859656003214	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
859656003215	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656003216	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656003217	substrate binding pocket [chemical binding]; other site
859656003218	membrane-bound complex binding site; other site
859656003219	hinge residues; other site
859656003220	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859656003221	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859656003222	Walker A/P-loop; other site
859656003223	ATP binding site [chemical binding]; other site
859656003224	Q-loop/lid; other site
859656003225	ABC transporter signature motif; other site
859656003226	Walker B; other site
859656003227	D-loop; other site
859656003228	H-loop/switch region; other site
859656003229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656003230	dimer interface [polypeptide binding]; other site
859656003231	conserved gate region; other site
859656003232	putative PBP binding loops; other site
859656003233	ABC-ATPase subunit interface; other site
859656003234	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656003235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656003236	dimer interface [polypeptide binding]; other site
859656003237	conserved gate region; other site
859656003238	putative PBP binding loops; other site
859656003239	ABC-ATPase subunit interface; other site
859656003240	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656003241	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656003242	substrate binding pocket [chemical binding]; other site
859656003243	membrane-bound complex binding site; other site
859656003244	hinge residues; other site
859656003245	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
859656003246	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859656003247	Bacterial transcriptional regulator; Region: IclR; pfam01614
859656003248	Coenzyme A transferase; Region: CoA_trans; cl17247
859656003249	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
859656003250	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
859656003251	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859656003252	dimer interface [polypeptide binding]; other site
859656003253	active site
859656003254	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
859656003255	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
859656003256	tetramer interface [polypeptide binding]; other site
859656003257	active site
859656003258	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
859656003259	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859656003260	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
859656003261	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859656003262	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656003263	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656003264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656003265	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859656003266	substrate binding pocket [chemical binding]; other site
859656003267	dimerization interface [polypeptide binding]; other site
859656003268	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
859656003269	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859656003270	Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase [Carbohydrate transport and metabolism]; Region: COG2342
859656003271	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
859656003272	rRNA binding site [nucleotide binding]; other site
859656003273	predicted 30S ribosome binding site; other site
859656003274	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
859656003275	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
859656003276	active site
859656003277	tetramer interface; other site
859656003278	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
859656003279	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656003280	active site
859656003281	HIGH motif; other site
859656003282	nucleotide binding site [chemical binding]; other site
859656003283	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
859656003284	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
859656003285	active site
859656003286	KMSKS motif; other site
859656003287	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
859656003288	tRNA binding surface [nucleotide binding]; other site
859656003289	anticodon binding site; other site
859656003290	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
859656003291	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
859656003292	Part of AAA domain; Region: AAA_19; pfam13245
859656003293	Family description; Region: UvrD_C_2; pfam13538
859656003294	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
859656003295	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
859656003296	putative active site [active]
859656003297	putative substrate binding site [chemical binding]; other site
859656003298	ATP binding site [chemical binding]; other site
859656003299	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
859656003300	DNA polymerase I; Provisional; Region: PRK05755
859656003301	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
859656003302	active site
859656003303	metal binding site 1 [ion binding]; metal-binding site
859656003304	putative 5' ssDNA interaction site; other site
859656003305	metal binding site 3; metal-binding site
859656003306	metal binding site 2 [ion binding]; metal-binding site
859656003307	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
859656003308	putative DNA binding site [nucleotide binding]; other site
859656003309	putative metal binding site [ion binding]; other site
859656003310	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
859656003311	ADP-ribose binding site [chemical binding]; other site
859656003312	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
859656003313	active site
859656003314	catalytic site [active]
859656003315	substrate binding site [chemical binding]; other site
859656003316	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
859656003317	active site
859656003318	DNA binding site [nucleotide binding]
859656003319	catalytic site [active]
859656003320	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
859656003321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656003322	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
859656003323	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
859656003324	ZIP Zinc transporter; Region: Zip; pfam02535
859656003325	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
859656003326	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
859656003327	active site residue [active]
859656003328	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
859656003329	active site residue [active]
859656003330	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656003331	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
859656003332	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
859656003333	[2Fe-2S] cluster binding site [ion binding]; other site
859656003334	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
859656003335	alpha subunit interface [polypeptide binding]; other site
859656003336	active site
859656003337	substrate binding site [chemical binding]; other site
859656003338	Fe binding site [ion binding]; other site
859656003339	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656003340	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
859656003341	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
859656003342	substrate binding pocket [chemical binding]; other site
859656003343	chain length determination region; other site
859656003344	substrate-Mg2+ binding site; other site
859656003345	catalytic residues [active]
859656003346	aspartate-rich region 1; other site
859656003347	active site lid residues [active]
859656003348	aspartate-rich region 2; other site
859656003349	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
859656003350	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
859656003351	TPP-binding site; other site
859656003352	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
859656003353	PYR/PP interface [polypeptide binding]; other site
859656003354	dimer interface [polypeptide binding]; other site
859656003355	TPP binding site [chemical binding]; other site
859656003356	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
859656003357	putative GTP cyclohydrolase; Provisional; Region: PRK13674
859656003358	UGMP family protein; Validated; Region: PRK09604
859656003359	HI0933-like protein; Region: HI0933_like; pfam03486
859656003360	Yqey-like protein; Region: YqeY; pfam09424
859656003361	DNA primase; Validated; Region: dnaG; PRK05667
859656003362	CHC2 zinc finger; Region: zf-CHC2; pfam01807
859656003363	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
859656003364	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
859656003365	active site
859656003366	metal binding site [ion binding]; metal-binding site
859656003367	interdomain interaction site; other site
859656003368	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
859656003369	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
859656003370	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
859656003371	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
859656003372	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859656003373	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
859656003374	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656003375	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
859656003376	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656003377	DNA binding residues [nucleotide binding]
859656003378	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656003379	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656003380	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656003381	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
859656003382	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656003383	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859656003384	DEAD-like helicases superfamily; Region: DEXDc; smart00487
859656003385	ATP binding site [chemical binding]; other site
859656003386	Mg++ binding site [ion binding]; other site
859656003387	motif III; other site
859656003388	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656003389	nucleotide binding region [chemical binding]; other site
859656003390	ATP-binding site [chemical binding]; other site
859656003391	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
859656003392	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
859656003393	active site
859656003394	HIGH motif; other site
859656003395	nucleotide binding site [chemical binding]; other site
859656003396	active site
859656003397	KMSKS motif; other site
859656003398	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
859656003399	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656003400	The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431
859656003401	putative dimerization interface [polypeptide binding]; other site
859656003402	Pirin-related protein [General function prediction only]; Region: COG1741
859656003403	Pirin; Region: Pirin; pfam02678
859656003404	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
859656003405	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656003406	rhodanese superfamily protein; Provisional; Region: PRK05320
859656003407	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
859656003408	active site residue [active]
859656003409	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
859656003410	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
859656003411	putative active site [active]
859656003412	putative PHP Thumb interface [polypeptide binding]; other site
859656003413	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
859656003414	generic binding surface II; other site
859656003415	generic binding surface I; other site
859656003416	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
859656003417	O-Antigen ligase; Region: Wzy_C; pfam04932
859656003418	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859656003419	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
859656003420	active site
859656003421	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
859656003422	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859656003423	putative metal binding site; other site
859656003424	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656003425	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656003426	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
859656003427	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859656003428	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
859656003429	Walker A/P-loop; other site
859656003430	ATP binding site [chemical binding]; other site
859656003431	Q-loop/lid; other site
859656003432	ABC transporter signature motif; other site
859656003433	Walker B; other site
859656003434	D-loop; other site
859656003435	H-loop/switch region; other site
859656003436	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
859656003437	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
859656003438	ribonuclease G; Provisional; Region: PRK11712
859656003439	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
859656003440	homodimer interface [polypeptide binding]; other site
859656003441	oligonucleotide binding site [chemical binding]; other site
859656003442	Maf-like protein; Region: Maf; pfam02545
859656003443	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
859656003444	active site
859656003445	dimer interface [polypeptide binding]; other site
859656003446	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
859656003447	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
859656003448	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
859656003449	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
859656003450	active site
859656003451	(T/H)XGH motif; other site
859656003452	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
859656003453	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
859656003454	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
859656003455	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
859656003456	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
859656003457	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
859656003458	hypothetical protein; Validated; Region: PRK00110
859656003459	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
859656003460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656003461	Walker A motif; other site
859656003462	ATP binding site [chemical binding]; other site
859656003463	Zonular occludens toxin (Zot); Region: Zot; cl17485
859656003464	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656003465	active site
859656003466	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859656003467	EamA-like transporter family; Region: EamA; pfam00892
859656003468	EamA-like transporter family; Region: EamA; pfam00892
859656003469	short chain dehydrogenase; Provisional; Region: PRK08339
859656003470	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
859656003471	putative NAD(P) binding site [chemical binding]; other site
859656003472	putative active site [active]
859656003473	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
859656003474	active site
859656003475	dimer interfaces [polypeptide binding]; other site
859656003476	catalytic residues [active]
859656003477	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
859656003478	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
859656003479	NADP binding site [chemical binding]; other site
859656003480	dimer interface [polypeptide binding]; other site
859656003481	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
859656003482	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
859656003483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656003484	FeS/SAM binding site; other site
859656003485	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
859656003486	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
859656003487	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
859656003488	putative ligand binding site [chemical binding]; other site
859656003489	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656003490	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
859656003491	TM-ABC transporter signature motif; other site
859656003492	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656003493	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
859656003494	TM-ABC transporter signature motif; other site
859656003495	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
859656003496	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859656003497	Walker A/P-loop; other site
859656003498	ATP binding site [chemical binding]; other site
859656003499	Q-loop/lid; other site
859656003500	ABC transporter signature motif; other site
859656003501	Walker B; other site
859656003502	D-loop; other site
859656003503	H-loop/switch region; other site
859656003504	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859656003505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656003506	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
859656003507	putative substrate translocation pore; other site
859656003508	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
859656003509	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
859656003510	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
859656003511	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
859656003512	putative active site [active]
859656003513	Predicted membrane protein [Function unknown]; Region: COG3819
859656003514	Predicted membrane protein [Function unknown]; Region: COG3817
859656003515	Protein of unknown function (DUF979); Region: DUF979; pfam06166
859656003516	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
859656003517	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
859656003518	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
859656003519	putative substrate binding pocket [chemical binding]; other site
859656003520	AC domain interface; other site
859656003521	catalytic triad [active]
859656003522	AB domain interface; other site
859656003523	interchain disulfide; other site
859656003524	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
859656003525	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
859656003526	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
859656003527	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
859656003528	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
859656003529	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
859656003530	active site
859656003531	Int/Topo IB signature motif; other site
859656003532	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
859656003533	Helix-turn-helix domain; Region: HTH_39; pfam14090
859656003534	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
859656003535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656003536	FeS/SAM binding site; other site
859656003537	HemN C-terminal domain; Region: HemN_C; pfam06969
859656003538	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
859656003539	active site
859656003540	dimerization interface [polypeptide binding]; other site
859656003541	ribonuclease PH; Reviewed; Region: rph; PRK00173
859656003542	Ribonuclease PH; Region: RNase_PH_bact; cd11362
859656003543	hexamer interface [polypeptide binding]; other site
859656003544	active site
859656003545	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
859656003546	active site
859656003547	Protein kinase domain; Region: Pkinase; pfam00069
859656003548	Catalytic domain of Protein Kinases; Region: PKc; cd00180
859656003549	active site
859656003550	ATP binding site [chemical binding]; other site
859656003551	substrate binding site [chemical binding]; other site
859656003552	activation loop (A-loop); other site
859656003553	hypothetical protein; Provisional; Region: PRK11820
859656003554	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
859656003555	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
859656003556	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
859656003557	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
859656003558	catalytic site [active]
859656003559	G-X2-G-X-G-K; other site
859656003560	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
859656003561	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
859656003562	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656003563	Zn2+ binding site [ion binding]; other site
859656003564	Mg2+ binding site [ion binding]; other site
859656003565	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
859656003566	synthetase active site [active]
859656003567	NTP binding site [chemical binding]; other site
859656003568	metal binding site [ion binding]; metal-binding site
859656003569	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
859656003570	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
859656003571	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
859656003572	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
859656003573	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
859656003574	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
859656003575	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
859656003576	BON domain; Region: BON; pfam04972
859656003577	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859656003578	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
859656003579	AMP binding site [chemical binding]; other site
859656003580	metal binding site [ion binding]; metal-binding site
859656003581	active site
859656003582	aminopeptidase N; Provisional; Region: pepN; PRK14015
859656003583	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
859656003584	active site
859656003585	Zn binding site [ion binding]; other site
859656003586	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
859656003587	malic enzyme; Reviewed; Region: PRK12862
859656003588	Malic enzyme, N-terminal domain; Region: malic; pfam00390
859656003589	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
859656003590	putative NAD(P) binding site [chemical binding]; other site
859656003591	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
859656003592	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656003593	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656003594	eyelet of channel; other site
859656003595	trimer interface [polypeptide binding]; other site
859656003596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
859656003597	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
859656003598	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
859656003599	active site
859656003600	catalytic site [active]
859656003601	tetramer interface [polypeptide binding]; other site
859656003602	xanthine permease; Region: pbuX; TIGR03173
859656003603	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656003604	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859656003605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656003606	DNA-binding site [nucleotide binding]; DNA binding site
859656003607	FCD domain; Region: FCD; pfam07729
859656003608	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
859656003609	active site
859656003610	homotetramer interface [polypeptide binding]; other site
859656003611	Predicted membrane protein [Function unknown]; Region: COG3748
859656003612	Protein of unknown function (DUF989); Region: DUF989; pfam06181
859656003613	Cytochrome c; Region: Cytochrom_C; pfam00034
859656003614	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
859656003615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656003616	NAD(P) binding site [chemical binding]; other site
859656003617	active site
859656003618	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
859656003619	Uncharacterized conserved protein [Function unknown]; Region: COG1359
859656003620	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
859656003621	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
859656003622	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
859656003623	potential catalytic triad [active]
859656003624	conserved cys residue [active]
859656003625	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859656003626	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
859656003627	putative NAD(P) binding site [chemical binding]; other site
859656003628	putative substrate binding site [chemical binding]; other site
859656003629	catalytic Zn binding site [ion binding]; other site
859656003630	structural Zn binding site [ion binding]; other site
859656003631	dimer interface [polypeptide binding]; other site
859656003632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656003633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656003634	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
859656003635	putative effector binding pocket; other site
859656003636	putative dimerization interface [polypeptide binding]; other site
859656003637	Predicted membrane protein [Function unknown]; Region: COG2119
859656003638	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
859656003639	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
859656003640	guanine deaminase; Provisional; Region: PRK09228
859656003641	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
859656003642	active site
859656003643	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
859656003644	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
859656003645	active site
859656003646	purine riboside binding site [chemical binding]; other site
859656003647	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
859656003648	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
859656003649	XdhC Rossmann domain; Region: XdhC_C; pfam13478
859656003650	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
859656003651	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859656003652	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859656003653	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
859656003654	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656003655	catalytic loop [active]
859656003656	iron binding site [ion binding]; other site
859656003657	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859656003658	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
859656003659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656003660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656003661	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
859656003662	putative substrate binding pocket [chemical binding]; other site
859656003663	putative dimerization interface [polypeptide binding]; other site
859656003664	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
859656003665	PBP superfamily domain; Region: PBP_like_2; pfam12849
859656003666	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
859656003667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656003668	Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910
859656003669	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
859656003670	FtsX-like permease family; Region: FtsX; pfam02687
859656003671	FtsX-like permease family; Region: FtsX; pfam02687
859656003672	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
859656003673	apolar tunnel; other site
859656003674	heme binding site [chemical binding]; other site
859656003675	dimerization interface [polypeptide binding]; other site
859656003676	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
859656003677	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859656003678	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
859656003679	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656003680	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656003681	Bacterial transcriptional repressor; Region: TetR; pfam13972
859656003682	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
859656003683	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
859656003684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859656003685	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656003686	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
859656003687	putative active site [active]
859656003688	putative metal binding site [ion binding]; other site
859656003689	PGAP1-like protein; Region: PGAP1; pfam07819
859656003690	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656003691	RDD family; Region: RDD; pfam06271
859656003692	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
859656003693	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
859656003694	RNA polymerase factor sigma-70; Validated; Region: PRK09047
859656003695	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656003696	DNA binding residues [nucleotide binding]
859656003697	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
859656003698	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859656003699	PYR/PP interface [polypeptide binding]; other site
859656003700	dimer interface [polypeptide binding]; other site
859656003701	TPP binding site [chemical binding]; other site
859656003702	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859656003703	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
859656003704	TPP-binding site [chemical binding]; other site
859656003705	dimer interface [polypeptide binding]; other site
859656003706	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
859656003707	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
859656003708	putative valine binding site [chemical binding]; other site
859656003709	dimer interface [polypeptide binding]; other site
859656003710	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
859656003711	ketol-acid reductoisomerase; Provisional; Region: PRK05479
859656003712	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
859656003713	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
859656003714	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
859656003715	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
859656003716	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
859656003717	2-isopropylmalate synthase; Validated; Region: PRK00915
859656003718	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
859656003719	active site
859656003720	catalytic residues [active]
859656003721	metal binding site [ion binding]; metal-binding site
859656003722	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
859656003723	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656003724	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
859656003725	putative ligand binding site [chemical binding]; other site
859656003726	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
859656003727	16S/18S rRNA binding site [nucleotide binding]; other site
859656003728	S13e-L30e interaction site [polypeptide binding]; other site
859656003729	25S rRNA binding site [nucleotide binding]; other site
859656003730	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
859656003731	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
859656003732	RNase E interface [polypeptide binding]; other site
859656003733	trimer interface [polypeptide binding]; other site
859656003734	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
859656003735	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
859656003736	RNase E interface [polypeptide binding]; other site
859656003737	trimer interface [polypeptide binding]; other site
859656003738	active site
859656003739	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
859656003740	putative nucleic acid binding region [nucleotide binding]; other site
859656003741	G-X-X-G motif; other site
859656003742	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
859656003743	RNA binding site [nucleotide binding]; other site
859656003744	domain interface; other site
859656003745	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
859656003746	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
859656003747	NAD(P) binding site [chemical binding]; other site
859656003748	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
859656003749	triosephosphate isomerase; Provisional; Region: PRK14567
859656003750	substrate binding site [chemical binding]; other site
859656003751	dimer interface [polypeptide binding]; other site
859656003752	catalytic triad [active]
859656003753	Preprotein translocase SecG subunit; Region: SecG; pfam03840
859656003754	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
859656003755	NADH dehydrogenase subunit B; Validated; Region: PRK06411
859656003756	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
859656003757	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
859656003758	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
859656003759	NADH dehydrogenase subunit D; Validated; Region: PRK06075
859656003760	NADH dehydrogenase subunit E; Validated; Region: PRK07539
859656003761	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
859656003762	putative dimer interface [polypeptide binding]; other site
859656003763	[2Fe-2S] cluster binding site [ion binding]; other site
859656003764	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
859656003765	SLBB domain; Region: SLBB; pfam10531
859656003766	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
859656003767	NADH dehydrogenase subunit G; Validated; Region: PRK09129
859656003768	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656003769	catalytic loop [active]
859656003770	iron binding site [ion binding]; other site
859656003771	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
859656003772	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
859656003773	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
859656003774	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
859656003775	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
859656003776	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
859656003777	4Fe-4S binding domain; Region: Fer4; cl02805
859656003778	4Fe-4S binding domain; Region: Fer4; pfam00037
859656003779	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
859656003780	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
859656003781	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
859656003782	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
859656003783	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
859656003784	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
859656003785	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
859656003786	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
859656003787	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
859656003788	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
859656003789	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
859656003790	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
859656003791	dimer interface [polypeptide binding]; other site
859656003792	ADP-ribose binding site [chemical binding]; other site
859656003793	active site
859656003794	nudix motif; other site
859656003795	metal binding site [ion binding]; metal-binding site
859656003796	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
859656003797	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
859656003798	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
859656003799	FAD binding site [chemical binding]; other site
859656003800	substrate binding site [chemical binding]; other site
859656003801	catalytic base [active]
859656003802	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
859656003803	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
859656003804	active site
859656003805	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
859656003806	putative active site [active]
859656003807	putative catalytic site [active]
859656003808	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
859656003809	putative active site [active]
859656003810	putative catalytic site [active]
859656003811	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656003812	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
859656003813	putative ligand binding site [chemical binding]; other site
859656003814	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656003815	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656003816	TM-ABC transporter signature motif; other site
859656003817	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656003818	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656003819	TM-ABC transporter signature motif; other site
859656003820	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
859656003821	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656003822	Walker A/P-loop; other site
859656003823	ATP binding site [chemical binding]; other site
859656003824	Q-loop/lid; other site
859656003825	ABC transporter signature motif; other site
859656003826	Walker B; other site
859656003827	D-loop; other site
859656003828	H-loop/switch region; other site
859656003829	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
859656003830	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656003831	Walker A/P-loop; other site
859656003832	ATP binding site [chemical binding]; other site
859656003833	Q-loop/lid; other site
859656003834	ABC transporter signature motif; other site
859656003835	Walker B; other site
859656003836	D-loop; other site
859656003837	H-loop/switch region; other site
859656003838	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
859656003839	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
859656003840	alpha-gamma subunit interface [polypeptide binding]; other site
859656003841	beta-gamma subunit interface [polypeptide binding]; other site
859656003842	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
859656003843	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
859656003844	gamma-beta subunit interface [polypeptide binding]; other site
859656003845	alpha-beta subunit interface [polypeptide binding]; other site
859656003846	urease subunit alpha; Reviewed; Region: ureC; PRK13207
859656003847	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
859656003848	subunit interactions [polypeptide binding]; other site
859656003849	active site
859656003850	flap region; other site
859656003851	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
859656003852	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
859656003853	dimer interface [polypeptide binding]; other site
859656003854	catalytic residues [active]
859656003855	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
859656003856	UreF; Region: UreF; pfam01730
859656003857	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
859656003858	G1 box; other site
859656003859	GTP/Mg2+ binding site [chemical binding]; other site
859656003860	G2 box; other site
859656003861	Switch I region; other site
859656003862	G3 box; other site
859656003863	Switch II region; other site
859656003864	G4 box; other site
859656003865	G5 box; other site
859656003866	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
859656003867	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
859656003868	putative di-iron ligands [ion binding]; other site
859656003869	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
859656003870	Lysine efflux permease [General function prediction only]; Region: COG1279
859656003871	Evidence 4 : Homologs of previously reported genes of unknown function
859656003872	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
859656003873	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
859656003874	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
859656003875	C-terminal domain interface [polypeptide binding]; other site
859656003876	GSH binding site (G-site) [chemical binding]; other site
859656003877	dimer interface [polypeptide binding]; other site
859656003878	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
859656003879	N-terminal domain interface [polypeptide binding]; other site
859656003880	putative dimer interface [polypeptide binding]; other site
859656003881	active site
859656003882	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656003883	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656003884	active site
859656003885	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859656003886	CoenzymeA binding site [chemical binding]; other site
859656003887	subunit interaction site [polypeptide binding]; other site
859656003888	PHB binding site; other site
859656003889	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
859656003890	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656003891	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
859656003892	substrate binding pocket [chemical binding]; other site
859656003893	dimerization interface [polypeptide binding]; other site
859656003894	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
859656003895	Phosphotransferase enzyme family; Region: APH; pfam01636
859656003896	putative active site [active]
859656003897	putative substrate binding site [chemical binding]; other site
859656003898	ATP binding site [chemical binding]; other site
859656003899	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859656003900	catalytic core [active]
859656003901	enoyl-CoA hydratase; Provisional; Region: PRK07511
859656003902	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656003903	substrate binding site [chemical binding]; other site
859656003904	oxyanion hole (OAH) forming residues; other site
859656003905	trimer interface [polypeptide binding]; other site
859656003906	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
859656003907	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859656003908	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859656003909	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859656003910	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656003911	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
859656003912	C-terminal domain interface [polypeptide binding]; other site
859656003913	GSH binding site (G-site) [chemical binding]; other site
859656003914	dimer interface [polypeptide binding]; other site
859656003915	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
859656003916	putative N-terminal domain interface [polypeptide binding]; other site
859656003917	putative dimer interface [polypeptide binding]; other site
859656003918	putative substrate binding pocket (H-site) [chemical binding]; other site
859656003919	methionine aminotransferase; Validated; Region: PRK09082
859656003920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656003921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656003922	homodimer interface [polypeptide binding]; other site
859656003923	catalytic residue [active]
859656003924	PIN domain; Region: PIN_3; cl17397
859656003925	hypothetical protein; Validated; Region: PRK02101
859656003926	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
859656003927	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
859656003928	putative active site [active]
859656003929	Zn binding site [ion binding]; other site
859656003930	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859656003931	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859656003932	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
859656003933	aconitate hydratase; Provisional; Region: acnA; PRK12881
859656003934	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859656003935	substrate binding site [chemical binding]; other site
859656003936	ligand binding site [chemical binding]; other site
859656003937	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
859656003938	substrate binding site [chemical binding]; other site
859656003939	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
859656003940	2-methylcitrate dehydratase; Region: prpD; TIGR02330
859656003941	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
859656003942	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
859656003943	dimer interface [polypeptide binding]; other site
859656003944	active site
859656003945	citrylCoA binding site [chemical binding]; other site
859656003946	oxalacetate/citrate binding site [chemical binding]; other site
859656003947	coenzyme A binding site [chemical binding]; other site
859656003948	catalytic triad [active]
859656003949	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
859656003950	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
859656003951	tetramer interface [polypeptide binding]; other site
859656003952	active site
859656003953	Mg2+/Mn2+ binding site [ion binding]; other site
859656003954	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
859656003955	malate dehydrogenase; Provisional; Region: PRK05442
859656003956	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
859656003957	NAD(P) binding site [chemical binding]; other site
859656003958	dimer interface [polypeptide binding]; other site
859656003959	malate binding site [chemical binding]; other site
859656003960	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859656003961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656003962	DNA-binding site [nucleotide binding]; DNA binding site
859656003963	UTRA domain; Region: UTRA; pfam07702
859656003964	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
859656003965	Iron-sulfur protein interface; other site
859656003966	proximal quinone binding site [chemical binding]; other site
859656003967	SdhD (CybS) interface [polypeptide binding]; other site
859656003968	proximal heme binding site [chemical binding]; other site
859656003969	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
859656003970	SdhC subunit interface [polypeptide binding]; other site
859656003971	proximal heme binding site [chemical binding]; other site
859656003972	cardiolipin binding site; other site
859656003973	Iron-sulfur protein interface; other site
859656003974	proximal quinone binding site [chemical binding]; other site
859656003975	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
859656003976	L-aspartate oxidase; Provisional; Region: PRK06175
859656003977	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
859656003978	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
859656003979	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
859656003980	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
859656003981	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
859656003982	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
859656003983	dimer interface [polypeptide binding]; other site
859656003984	active site
859656003985	citrylCoA binding site [chemical binding]; other site
859656003986	NADH binding [chemical binding]; other site
859656003987	cationic pore residues; other site
859656003988	oxalacetate/citrate binding site [chemical binding]; other site
859656003989	coenzyme A binding site [chemical binding]; other site
859656003990	catalytic triad [active]
859656003991	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
859656003992	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
859656003993	substrate binding site [chemical binding]; other site
859656003994	ligand binding site [chemical binding]; other site
859656003995	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
859656003996	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
859656003997	substrate binding site [chemical binding]; other site
859656003998	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
859656003999	tartrate dehydrogenase; Region: TTC; TIGR02089
859656004000	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
859656004001	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
859656004002	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
859656004003	FimV N-terminal domain; Region: FimV_core; TIGR03505
859656004004	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
859656004005	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
859656004006	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
859656004007	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
859656004008	dimerization interface 3.5A [polypeptide binding]; other site
859656004009	active site
859656004010	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
859656004011	active site
859656004012	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
859656004013	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
859656004014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656004015	catalytic residue [active]
859656004016	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
859656004017	DNA methylase; Region: N6_N4_Mtase; pfam01555
859656004018	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
859656004019	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
859656004020	substrate binding site [chemical binding]; other site
859656004021	active site
859656004022	catalytic residues [active]
859656004023	heterodimer interface [polypeptide binding]; other site
859656004024	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
859656004025	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
859656004026	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
859656004027	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
859656004028	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
859656004029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
859656004030	Sporulation related domain; Region: SPOR; pfam05036
859656004031	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
859656004032	Colicin V production protein; Region: Colicin_V; pfam02674
859656004033	amidophosphoribosyltransferase; Provisional; Region: PRK09246
859656004034	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
859656004035	active site
859656004036	tetramer interface [polypeptide binding]; other site
859656004037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656004038	active site
859656004039	ABC-2 type transporter; Region: ABC2_membrane; cl17235
859656004040	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
859656004041	nodulation ABC transporter NodI; Provisional; Region: PRK13537
859656004042	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
859656004043	Walker A/P-loop; other site
859656004044	ATP binding site [chemical binding]; other site
859656004045	Q-loop/lid; other site
859656004046	ABC transporter signature motif; other site
859656004047	Walker B; other site
859656004048	D-loop; other site
859656004049	H-loop/switch region; other site
859656004050	phasin family protein; Region: phasin; TIGR01841
859656004051	Uncharacterized conserved protein [Function unknown]; Region: COG1434
859656004052	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
859656004053	putative active site [active]
859656004054	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
859656004055	Hemin uptake protein hemP; Region: hemP; cl10043
859656004056	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
859656004057	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
859656004058	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
859656004059	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
859656004060	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
859656004061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656004062	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
859656004063	Walker A motif; other site
859656004064	ATP binding site [chemical binding]; other site
859656004065	Walker B motif; other site
859656004066	arginine finger; other site
859656004067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656004068	Walker A motif; other site
859656004069	ATP binding site [chemical binding]; other site
859656004070	Walker B motif; other site
859656004071	arginine finger; other site
859656004072	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656004073	dimerization interface [polypeptide binding]; other site
859656004074	putative DNA binding site [nucleotide binding]; other site
859656004075	putative Zn2+ binding site [ion binding]; other site
859656004076	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
859656004077	putative hydrophobic ligand binding site [chemical binding]; other site
859656004078	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
859656004079	putative hydrophobic ligand binding site [chemical binding]; other site
859656004080	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859656004081	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
859656004082	glutamate racemase; Provisional; Region: PRK00865
859656004083	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
859656004084	Fumarase C-terminus; Region: Fumerase_C; pfam05683
859656004085	hypothetical protein; Provisional; Region: PRK05208
859656004086	acetyl-CoA synthetase; Provisional; Region: PRK00174
859656004087	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
859656004088	active site
859656004089	CoA binding site [chemical binding]; other site
859656004090	acyl-activating enzyme (AAE) consensus motif; other site
859656004091	AMP binding site [chemical binding]; other site
859656004092	acetate binding site [chemical binding]; other site
859656004093	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
859656004094	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
859656004095	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
859656004096	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656004097	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656004098	dimerization interface [polypeptide binding]; other site
859656004099	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656004100	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656004101	dimer interface [polypeptide binding]; other site
859656004102	putative CheW interface [polypeptide binding]; other site
859656004103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859656004104	transcriptional regulator EpsA; Region: EpsA; TIGR03020
859656004105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656004106	DNA binding residues [nucleotide binding]
859656004107	dimerization interface [polypeptide binding]; other site
859656004108	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656004109	dimer interface [polypeptide binding]; other site
859656004110	putative CheW interface [polypeptide binding]; other site
859656004111	Cache domain; Region: Cache_1; pfam02743
859656004112	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656004113	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656004114	metal binding site [ion binding]; metal-binding site
859656004115	active site
859656004116	I-site; other site
859656004117	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656004118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656004119	DNA binding site [nucleotide binding]
859656004120	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859656004121	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656004122	catalytic loop [active]
859656004123	iron binding site [ion binding]; other site
859656004124	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859656004125	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859656004126	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859656004127	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859656004128	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859656004129	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859656004130	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
859656004131	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
859656004132	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
859656004133	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
859656004134	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
859656004135	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859656004136	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
859656004137	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
859656004138	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656004139	Walker A/P-loop; other site
859656004140	ATP binding site [chemical binding]; other site
859656004141	Q-loop/lid; other site
859656004142	ABC transporter signature motif; other site
859656004143	Walker B; other site
859656004144	D-loop; other site
859656004145	H-loop/switch region; other site
859656004146	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
859656004147	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
859656004148	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656004149	Walker A/P-loop; other site
859656004150	ATP binding site [chemical binding]; other site
859656004151	Q-loop/lid; other site
859656004152	ABC transporter signature motif; other site
859656004153	Walker B; other site
859656004154	D-loop; other site
859656004155	H-loop/switch region; other site
859656004156	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859656004157	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
859656004158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656004159	dimer interface [polypeptide binding]; other site
859656004160	conserved gate region; other site
859656004161	putative PBP binding loops; other site
859656004162	ABC-ATPase subunit interface; other site
859656004163	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859656004164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656004165	dimer interface [polypeptide binding]; other site
859656004166	conserved gate region; other site
859656004167	putative PBP binding loops; other site
859656004168	ABC-ATPase subunit interface; other site
859656004169	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
859656004170	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
859656004171	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656004172	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656004173	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656004174	dimerization interface [polypeptide binding]; other site
859656004175	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656004176	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859656004177	putative ligand binding site [chemical binding]; other site
859656004178	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
859656004179	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
859656004180	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
859656004181	nudix motif; other site
859656004182	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
859656004183	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
859656004184	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
859656004185	putative active site [active]
859656004186	putative substrate binding site [chemical binding]; other site
859656004187	putative cosubstrate binding site; other site
859656004188	catalytic site [active]
859656004189	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
859656004190	active site
859656004191	catalytic site [active]
859656004192	substrate binding site [chemical binding]; other site
859656004193	integrase; Provisional; Region: PRK09692
859656004194	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
859656004195	active site
859656004196	Int/Topo IB signature motif; other site
859656004197	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
859656004198	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
859656004199	Helix-turn-helix domain; Region: HTH_39; pfam14090
859656004200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
859656004201	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
859656004202	active site
859656004203	metal binding site [ion binding]; metal-binding site
859656004204	interdomain interaction site; other site
859656004205	Protein of unknown function (DUF3631); Region: DUF3631; pfam12307
859656004206	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
859656004207	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
859656004208	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859656004209	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
859656004210	Excisionase-like protein; Region: Exc; pfam07825
859656004211	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
859656004212	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859656004213	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859656004214	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656004215	Ligand Binding Site [chemical binding]; other site
859656004216	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859656004217	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
859656004218	putative NAD(P) binding site [chemical binding]; other site
859656004219	putative substrate binding site [chemical binding]; other site
859656004220	catalytic Zn binding site [ion binding]; other site
859656004221	structural Zn binding site [ion binding]; other site
859656004222	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
859656004223	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
859656004224	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859656004225	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
859656004226	RNA/DNA hybrid binding site [nucleotide binding]; other site
859656004227	active site
859656004228	Methyltransferase domain; Region: Methyltransf_11; pfam08241
859656004229	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
859656004230	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
859656004231	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656004232	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656004233	catalytic residue [active]
859656004234	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859656004235	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
859656004236	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656004237	acyl-activating enzyme (AAE) consensus motif; other site
859656004238	AMP binding site [chemical binding]; other site
859656004239	active site
859656004240	CoA binding site [chemical binding]; other site
859656004241	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
859656004242	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
859656004243	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
859656004244	catalytic site [active]
859656004245	subunit interface [polypeptide binding]; other site
859656004246	leucine export protein LeuE; Provisional; Region: PRK10958
859656004247	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
859656004248	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859656004249	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
859656004250	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
859656004251	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859656004252	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859656004253	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
859656004254	IMP binding site; other site
859656004255	dimer interface [polypeptide binding]; other site
859656004256	interdomain contacts; other site
859656004257	partial ornithine binding site; other site
859656004258	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
859656004259	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
859656004260	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
859656004261	Evidence 4 : Homologs of previously reported genes of unknown function
859656004262	Evidence 4 : Homologs of previously reported genes of unknown function
859656004263	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
859656004264	FtsJ-like methyltransferase; Region: FtsJ; cl17430
859656004265	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
859656004266	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
859656004267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656004268	Walker A motif; other site
859656004269	ATP binding site [chemical binding]; other site
859656004270	Walker B motif; other site
859656004271	arginine finger; other site
859656004272	Peptidase family M41; Region: Peptidase_M41; pfam01434
859656004273	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
859656004274	dihydropteroate synthase; Region: DHPS; TIGR01496
859656004275	substrate binding pocket [chemical binding]; other site
859656004276	dimer interface [polypeptide binding]; other site
859656004277	inhibitor binding site; inhibition site
859656004278	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
859656004279	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
859656004280	active site
859656004281	substrate binding site [chemical binding]; other site
859656004282	metal binding site [ion binding]; metal-binding site
859656004283	PBP superfamily domain; Region: PBP_like_2; cl17296
859656004284	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
859656004285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656004286	dimer interface [polypeptide binding]; other site
859656004287	conserved gate region; other site
859656004288	putative PBP binding loops; other site
859656004289	ABC-ATPase subunit interface; other site
859656004290	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
859656004291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656004292	dimer interface [polypeptide binding]; other site
859656004293	conserved gate region; other site
859656004294	putative PBP binding loops; other site
859656004295	ABC-ATPase subunit interface; other site
859656004296	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
859656004297	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
859656004298	Walker A/P-loop; other site
859656004299	ATP binding site [chemical binding]; other site
859656004300	Q-loop/lid; other site
859656004301	ABC transporter signature motif; other site
859656004302	Walker B; other site
859656004303	D-loop; other site
859656004304	H-loop/switch region; other site
859656004305	transcriptional regulator PhoU; Provisional; Region: PRK11115
859656004306	PhoU domain; Region: PhoU; pfam01895
859656004307	PhoU domain; Region: PhoU; pfam01895
859656004308	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
859656004309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656004310	active site
859656004311	phosphorylation site [posttranslational modification]
859656004312	intermolecular recognition site; other site
859656004313	dimerization interface [polypeptide binding]; other site
859656004314	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656004315	DNA binding site [nucleotide binding]
859656004316	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
859656004317	PAS domain; Region: PAS; smart00091
859656004318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656004319	dimer interface [polypeptide binding]; other site
859656004320	phosphorylation site [posttranslational modification]
859656004321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656004322	ATP binding site [chemical binding]; other site
859656004323	Mg2+ binding site [ion binding]; other site
859656004324	G-X-G motif; other site
859656004325	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
859656004326	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
859656004327	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
859656004328	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
859656004329	putative domain interface [polypeptide binding]; other site
859656004330	putative active site [active]
859656004331	catalytic site [active]
859656004332	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
859656004333	putative domain interface [polypeptide binding]; other site
859656004334	putative active site [active]
859656004335	catalytic site [active]
859656004336	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
859656004337	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
859656004338	Putative hemolysin [General function prediction only]; Region: COG3176
859656004339	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
859656004340	catalytic core [active]
859656004341	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
859656004342	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656004343	dimerization interface [polypeptide binding]; other site
859656004344	putative DNA binding site [nucleotide binding]; other site
859656004345	putative Zn2+ binding site [ion binding]; other site
859656004346	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859656004347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656004348	metal binding site [ion binding]; metal-binding site
859656004349	active site
859656004350	I-site; other site
859656004351	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656004352	Protein kinase domain; Region: Pkinase; pfam00069
859656004353	Catalytic domain of Protein Kinases; Region: PKc; cd00180
859656004354	active site
859656004355	ATP binding site [chemical binding]; other site
859656004356	substrate binding site [chemical binding]; other site
859656004357	activation loop (A-loop); other site
859656004358	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656004359	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656004360	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656004361	Ligand Binding Site [chemical binding]; other site
859656004362	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
859656004363	FOG: CBS domain [General function prediction only]; Region: COG0517
859656004364	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
859656004365	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656004366	Ligand Binding Site [chemical binding]; other site
859656004367	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
859656004368	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859656004369	ligand binding site [chemical binding]; other site
859656004370	flexible hinge region; other site
859656004371	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859656004372	putative switch regulator; other site
859656004373	non-specific DNA interactions [nucleotide binding]; other site
859656004374	DNA binding site [nucleotide binding]
859656004375	sequence specific DNA binding site [nucleotide binding]; other site
859656004376	putative cAMP binding site [chemical binding]; other site
859656004377	PAS domain S-box; Region: sensory_box; TIGR00229
859656004378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656004379	putative active site [active]
859656004380	heme pocket [chemical binding]; other site
859656004381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
859656004382	Histidine kinase; Region: HisKA_3; pfam07730
859656004383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656004384	ATP binding site [chemical binding]; other site
859656004385	Mg2+ binding site [ion binding]; other site
859656004386	G-X-G motif; other site
859656004387	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656004388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656004389	active site
859656004390	phosphorylation site [posttranslational modification]
859656004391	intermolecular recognition site; other site
859656004392	dimerization interface [polypeptide binding]; other site
859656004393	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656004394	DNA binding residues [nucleotide binding]
859656004395	dimerization interface [polypeptide binding]; other site
859656004396	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
859656004397	hypothetical protein; Validated; Region: PRK09169
859656004398	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859656004399	metal binding triad [ion binding]; metal-binding site
859656004400	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
859656004401	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
859656004402	mce related protein; Region: MCE; pfam02470
859656004403	mce related protein; Region: MCE; pfam02470
859656004404	mce related protein; Region: MCE; pfam02470
859656004405	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656004406	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656004407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
859656004408	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
859656004409	phosphodiesterase YaeI; Provisional; Region: PRK11340
859656004410	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
859656004411	putative active site [active]
859656004412	putative metal binding site [ion binding]; other site
859656004413	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656004414	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656004415	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656004416	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656004417	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656004418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656004419	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859656004420	FAD binding domain; Region: FAD_binding_4; pfam01565
859656004421	Predicted membrane protein [Function unknown]; Region: COG3308
859656004422	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
859656004423	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656004424	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
859656004425	Predicted membrane protein [Function unknown]; Region: COG4323
859656004426	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656004427	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656004428	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859656004429	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
859656004430	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
859656004431	homodimer interface [polypeptide binding]; other site
859656004432	substrate-cofactor binding pocket; other site
859656004433	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656004434	catalytic residue [active]
859656004435	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625
859656004436	FOG: CBS domain [General function prediction only]; Region: COG0517
859656004437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656004438	putative substrate translocation pore; other site
859656004439	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859656004440	putative acyl-acceptor binding pocket; other site
859656004441	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
859656004442	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859656004443	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
859656004444	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
859656004445	Tetramer interface [polypeptide binding]; other site
859656004446	active site
859656004447	FMN-binding site [chemical binding]; other site
859656004448	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
859656004449	hydroxyglutarate oxidase; Provisional; Region: PRK11728
859656004450	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
859656004451	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
859656004452	short chain dehydrogenase; Provisional; Region: PRK06949
859656004453	classical (c) SDRs; Region: SDR_c; cd05233
859656004454	NAD(P) binding site [chemical binding]; other site
859656004455	active site
859656004456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656004457	PAS domain; Region: PAS_9; pfam13426
859656004458	putative active site [active]
859656004459	heme pocket [chemical binding]; other site
859656004460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656004461	DNA binding residues [nucleotide binding]
859656004462	dimerization interface [polypeptide binding]; other site
859656004463	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
859656004464	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
859656004465	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
859656004466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656004467	NAD(P) binding site [chemical binding]; other site
859656004468	active site
859656004469	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656004470	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656004471	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
859656004472	homotrimer interaction site [polypeptide binding]; other site
859656004473	putative active site [active]
859656004474	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
859656004475	HD domain; Region: HD_4; pfam13328
859656004476	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
859656004477	synthetase active site [active]
859656004478	NTP binding site [chemical binding]; other site
859656004479	metal binding site [ion binding]; metal-binding site
859656004480	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
859656004481	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
859656004482	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
859656004483	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
859656004484	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
859656004485	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
859656004486	active site
859656004487	dimer interface [polypeptide binding]; other site
859656004488	motif 1; other site
859656004489	motif 2; other site
859656004490	motif 3; other site
859656004491	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
859656004492	anticodon binding site; other site
859656004493	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
859656004494	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
859656004495	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
859656004496	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
859656004497	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
859656004498	23S rRNA binding site [nucleotide binding]; other site
859656004499	L21 binding site [polypeptide binding]; other site
859656004500	L13 binding site [polypeptide binding]; other site
859656004501	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
859656004502	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
859656004503	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
859656004504	dimer interface [polypeptide binding]; other site
859656004505	motif 1; other site
859656004506	active site
859656004507	motif 2; other site
859656004508	motif 3; other site
859656004509	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
859656004510	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
859656004511	putative tRNA-binding site [nucleotide binding]; other site
859656004512	B3/4 domain; Region: B3_4; pfam03483
859656004513	tRNA synthetase B5 domain; Region: B5; smart00874
859656004514	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
859656004515	dimer interface [polypeptide binding]; other site
859656004516	motif 1; other site
859656004517	motif 3; other site
859656004518	motif 2; other site
859656004519	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
859656004520	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859656004521	IHF dimer interface [polypeptide binding]; other site
859656004522	IHF - DNA interface [nucleotide binding]; other site
859656004523	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
859656004524	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859656004525	DNA binding residues [nucleotide binding]
859656004526	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859656004527	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
859656004528	active site
859656004529	DNA binding site [nucleotide binding]
859656004530	Int/Topo IB signature motif; other site
859656004531	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656004532	RHS Repeat; Region: RHS_repeat; pfam05593
859656004533	RHS Repeat; Region: RHS_repeat; pfam05593
859656004534	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656004535	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656004536	RHS Repeat; Region: RHS_repeat; cl11982
859656004537	RHS Repeat; Region: RHS_repeat; pfam05593
859656004538	RHS Repeat; Region: RHS_repeat; pfam05593
859656004539	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859656004540	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656004541	RHS Repeat; Region: RHS_repeat; pfam05593
859656004542	RHS Repeat; Region: RHS_repeat; pfam05593
859656004543	RHS Repeat; Region: RHS_repeat; pfam05593
859656004544	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
859656004545	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
859656004546	catalytic residues [active]
859656004547	catalytic nucleophile [active]
859656004548	Presynaptic Site I dimer interface [polypeptide binding]; other site
859656004549	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
859656004550	Synaptic Flat tetramer interface [polypeptide binding]; other site
859656004551	Synaptic Site I dimer interface [polypeptide binding]; other site
859656004552	DNA binding site [nucleotide binding]
859656004553	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656004554	MULE transposase domain; Region: MULE; pfam10551
859656004555	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
859656004556	active site
859656004557	catalytic residues [active]
859656004558	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
859656004559	active site
859656004560	DNA polymerase IV; Validated; Region: PRK02406
859656004561	DNA binding site [nucleotide binding]
859656004562	amino acid transporter; Region: 2A0306; TIGR00909
859656004563	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
859656004564	Uncharacterized secreted protein [Function unknown]; Region: COG5429
859656004565	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859656004566	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
859656004567	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
859656004568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656004569	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
859656004570	putative catalytic site [active]
859656004571	putative phosphate binding site [ion binding]; other site
859656004572	active site
859656004573	metal binding site A [ion binding]; metal-binding site
859656004574	DNA binding site [nucleotide binding]
859656004575	putative AP binding site [nucleotide binding]; other site
859656004576	putative metal binding site B [ion binding]; other site
859656004577	cytosine deaminase; Validated; Region: PRK07572
859656004578	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
859656004579	active site
859656004580	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
859656004581	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
859656004582	active site
859656004583	Zn binding site [ion binding]; other site
859656004584	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
859656004585	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
859656004586	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
859656004587	homodimer interface [polypeptide binding]; other site
859656004588	NADP binding site [chemical binding]; other site
859656004589	substrate binding site [chemical binding]; other site
859656004590	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
859656004591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656004592	active site
859656004593	phosphorylation site [posttranslational modification]
859656004594	intermolecular recognition site; other site
859656004595	dimerization interface [polypeptide binding]; other site
859656004596	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656004597	DNA binding residues [nucleotide binding]
859656004598	dimerization interface [polypeptide binding]; other site
859656004599	PAS domain S-box; Region: sensory_box; TIGR00229
859656004600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656004601	putative active site [active]
859656004602	heme pocket [chemical binding]; other site
859656004603	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
859656004604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656004605	dimer interface [polypeptide binding]; other site
859656004606	phosphorylation site [posttranslational modification]
859656004607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656004608	ATP binding site [chemical binding]; other site
859656004609	Mg2+ binding site [ion binding]; other site
859656004610	G-X-G motif; other site
859656004611	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
859656004612	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
859656004613	dimer interface [polypeptide binding]; other site
859656004614	TPP-binding site [chemical binding]; other site
859656004615	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
859656004616	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
859656004617	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859656004618	E3 interaction surface; other site
859656004619	lipoyl attachment site [posttranslational modification]; other site
859656004620	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859656004621	E3 interaction surface; other site
859656004622	lipoyl attachment site [posttranslational modification]; other site
859656004623	e3 binding domain; Region: E3_binding; pfam02817
859656004624	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
859656004625	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
859656004626	active site
859656004627	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859656004628	E3 interaction surface; other site
859656004629	lipoyl attachment site [posttranslational modification]; other site
859656004630	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
859656004631	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656004632	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859656004633	Phasin protein; Region: Phasin_2; pfam09361
859656004634	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
859656004635	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
859656004636	putative active site [active]
859656004637	Zn binding site [ion binding]; other site
859656004638	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656004639	EamA-like transporter family; Region: EamA; pfam00892
859656004640	EamA-like transporter family; Region: EamA; pfam00892
859656004641	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859656004642	active site
859656004643	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
859656004644	putative FMN binding site [chemical binding]; other site
859656004645	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
859656004646	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
859656004647	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859656004648	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859656004649	Bacterial transcriptional regulator; Region: IclR; pfam01614
859656004650	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
859656004651	Cysteine-rich domain; Region: CCG; pfam02754
859656004652	Cysteine-rich domain; Region: CCG; pfam02754
859656004653	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
859656004654	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
859656004655	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859656004656	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
859656004657	TM2 domain; Region: TM2; pfam05154
859656004658	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
859656004659	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
859656004660	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
859656004661	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
859656004662	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
859656004663	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
859656004664	nudix motif; other site
859656004665	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
859656004666	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
859656004667	quinone interaction residues [chemical binding]; other site
859656004668	active site
859656004669	catalytic residues [active]
859656004670	FMN binding site [chemical binding]; other site
859656004671	substrate binding site [chemical binding]; other site
859656004672	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
859656004673	potassium uptake protein; Region: kup; TIGR00794
859656004674	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
859656004675	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
859656004676	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
859656004677	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
859656004678	RNA binding site [nucleotide binding]; other site
859656004679	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
859656004680	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
859656004681	DEAD_2; Region: DEAD_2; pfam06733
859656004682	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
859656004683	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
859656004684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
859656004685	binding surface
859656004686	TPR motif; other site
859656004687	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
859656004688	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656004689	RNA binding surface [nucleotide binding]; other site
859656004690	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
859656004691	active site
859656004692	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
859656004693	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
859656004694	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
859656004695	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
859656004696	putative acyltransferase; Provisional; Region: PRK05790
859656004697	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859656004698	dimer interface [polypeptide binding]; other site
859656004699	active site
859656004700	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
859656004701	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859656004702	NAD(P) binding site [chemical binding]; other site
859656004703	homotetramer interface [polypeptide binding]; other site
859656004704	homodimer interface [polypeptide binding]; other site
859656004705	active site
859656004706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
859656004707	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
859656004708	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
859656004709	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
859656004710	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
859656004711	FMN binding site [chemical binding]; other site
859656004712	active site
859656004713	catalytic residues [active]
859656004714	substrate binding site [chemical binding]; other site
859656004715	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
859656004716	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
859656004717	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656004718	FeS/SAM binding site; other site
859656004719	TRAM domain; Region: TRAM; cl01282
859656004720	beta-ketothiolase; Provisional; Region: PRK09051
859656004721	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859656004722	dimer interface [polypeptide binding]; other site
859656004723	active site
859656004724	cystathionine beta-lyase; Provisional; Region: PRK07050
859656004725	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859656004726	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656004727	catalytic residue [active]
859656004728	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
859656004729	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
859656004730	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
859656004731	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
859656004732	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656004733	motif II; other site
859656004734	acetylornithine deacetylase; Provisional; Region: PRK07522
859656004735	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
859656004736	metal binding site [ion binding]; metal-binding site
859656004737	putative dimer interface [polypeptide binding]; other site
859656004738	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
859656004739	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
859656004740	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656004741	ATP binding site [chemical binding]; other site
859656004742	putative Mg++ binding site [ion binding]; other site
859656004743	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656004744	nucleotide binding region [chemical binding]; other site
859656004745	ATP-binding site [chemical binding]; other site
859656004746	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
859656004747	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
859656004748	substrate binding site; other site
859656004749	dimer interface; other site
859656004750	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
859656004751	homotrimer interaction site [polypeptide binding]; other site
859656004752	zinc binding site [ion binding]; other site
859656004753	CDP-binding sites; other site
859656004754	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
859656004755	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
859656004756	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
859656004757	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
859656004758	dimer interface [polypeptide binding]; other site
859656004759	decamer (pentamer of dimers) interface [polypeptide binding]; other site
859656004760	catalytic triad [active]
859656004761	peroxidatic and resolving cysteines [active]
859656004762	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
859656004763	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656004764	dimerization interface [polypeptide binding]; other site
859656004765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656004766	ATP binding site [chemical binding]; other site
859656004767	Mg2+ binding site [ion binding]; other site
859656004768	G-X-G motif; other site
859656004769	osmolarity response regulator; Provisional; Region: ompR; PRK09468
859656004770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656004771	active site
859656004772	phosphorylation site [posttranslational modification]
859656004773	intermolecular recognition site; other site
859656004774	dimerization interface [polypeptide binding]; other site
859656004775	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656004776	DNA binding site [nucleotide binding]
859656004777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267
859656004778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
859656004779	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
859656004780	active site lid residues [active]
859656004781	substrate binding pocket [chemical binding]; other site
859656004782	catalytic residues [active]
859656004783	substrate-Mg2+ binding site; other site
859656004784	aspartate-rich region 1; other site
859656004785	aspartate-rich region 2; other site
859656004786	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656004787	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656004788	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656004789	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
859656004790	Uncharacterized conserved protein [Function unknown]; Region: COG4121
859656004791	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859656004792	trigger factor; Provisional; Region: tig; PRK01490
859656004793	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859656004794	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
859656004795	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
859656004796	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
859656004797	oligomer interface [polypeptide binding]; other site
859656004798	active site residues [active]
859656004799	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
859656004800	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
859656004801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656004802	Walker A motif; other site
859656004803	ATP binding site [chemical binding]; other site
859656004804	Walker B motif; other site
859656004805	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
859656004806	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
859656004807	Found in ATP-dependent protease La (LON); Region: LON; smart00464
859656004808	Found in ATP-dependent protease La (LON); Region: LON; smart00464
859656004809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656004810	Walker A motif; other site
859656004811	ATP binding site [chemical binding]; other site
859656004812	Walker B motif; other site
859656004813	arginine finger; other site
859656004814	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
859656004815	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859656004816	IHF dimer interface [polypeptide binding]; other site
859656004817	IHF - DNA interface [nucleotide binding]; other site
859656004818	periplasmic folding chaperone; Provisional; Region: PRK10788
859656004819	SurA N-terminal domain; Region: SurA_N_3; cl07813
859656004820	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859656004821	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
859656004822	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859656004823	Catalytic site [active]
859656004824	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859656004825	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
859656004826	active site
859656004827	catalytic triad [active]
859656004828	oxyanion hole [active]
859656004829	switch loop; other site
859656004830	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
859656004831	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859656004832	Walker A/P-loop; other site
859656004833	ATP binding site [chemical binding]; other site
859656004834	Q-loop/lid; other site
859656004835	ABC transporter signature motif; other site
859656004836	Walker B; other site
859656004837	D-loop; other site
859656004838	H-loop/switch region; other site
859656004839	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
859656004840	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
859656004841	active site
859656004842	dimer interface [polypeptide binding]; other site
859656004843	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
859656004844	dimer interface [polypeptide binding]; other site
859656004845	active site
859656004846	putative carbohydrate kinase; Provisional; Region: PRK10565
859656004847	Uncharacterized conserved protein [Function unknown]; Region: COG0062
859656004848	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
859656004849	putative substrate binding site [chemical binding]; other site
859656004850	putative ATP binding site [chemical binding]; other site
859656004851	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
859656004852	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
859656004853	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
859656004854	dimerization interface [polypeptide binding]; other site
859656004855	ATP binding site [chemical binding]; other site
859656004856	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
859656004857	dimerization interface [polypeptide binding]; other site
859656004858	ATP binding site [chemical binding]; other site
859656004859	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
859656004860	putative active site [active]
859656004861	catalytic triad [active]
859656004862	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
859656004863	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
859656004864	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
859656004865	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
859656004866	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
859656004867	Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913
859656004868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656004869	FeS/SAM binding site; other site
859656004870	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
859656004871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656004872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656004873	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
859656004874	putative effector binding pocket; other site
859656004875	putative dimerization interface [polypeptide binding]; other site
859656004876	Mor transcription activator family; Region: Mor; pfam08765
859656004877	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
859656004878	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859656004879	IHF dimer interface [polypeptide binding]; other site
859656004880	IHF - DNA interface [nucleotide binding]; other site
859656004881	Gram-negative bacterial tonB protein; Region: TonB; cl10048
859656004882	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
859656004883	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
859656004884	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
859656004885	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656004886	Walker A/P-loop; other site
859656004887	ATP binding site [chemical binding]; other site
859656004888	Integrase core domain; Region: rve; pfam00665
859656004889	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
859656004890	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
859656004891	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656004892	non-specific DNA binding site [nucleotide binding]; other site
859656004893	salt bridge; other site
859656004894	sequence-specific DNA binding site [nucleotide binding]; other site
859656004895	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
859656004896	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656004897	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656004898	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656004899	catalytic residue [active]
859656004900	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
859656004901	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
859656004902	Protein of unknown function (DUF935); Region: DUF935; pfam06074
859656004903	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
859656004904	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
859656004905	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
859656004906	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
859656004907	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
859656004908	Gp37 protein; Region: Gp37; pfam09646
859656004909	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
859656004910	Phage tail tube protein FII; Region: Phage_tube; cl01390
859656004911	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
859656004912	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
859656004913	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
859656004914	Phage Tail Protein X; Region: Phage_tail_X; cl02088
859656004915	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
859656004916	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
859656004917	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
859656004918	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
859656004919	Baseplate J-like protein; Region: Baseplate_J; cl01294
859656004920	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
859656004921	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
859656004922	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
859656004923	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
859656004924	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
859656004925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656004926	NAD(P) binding site [chemical binding]; other site
859656004927	active site
859656004928	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859656004929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656004930	dimer interface [polypeptide binding]; other site
859656004931	conserved gate region; other site
859656004932	putative PBP binding loops; other site
859656004933	ABC-ATPase subunit interface; other site
859656004934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656004935	dimer interface [polypeptide binding]; other site
859656004936	conserved gate region; other site
859656004937	putative PBP binding loops; other site
859656004938	ABC-ATPase subunit interface; other site
859656004939	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
859656004940	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859656004941	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859656004942	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656004943	Walker A/P-loop; other site
859656004944	ATP binding site [chemical binding]; other site
859656004945	Q-loop/lid; other site
859656004946	ABC transporter signature motif; other site
859656004947	Walker B; other site
859656004948	D-loop; other site
859656004949	H-loop/switch region; other site
859656004950	TOBE domain; Region: TOBE_2; pfam08402
859656004951	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859656004952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656004953	dimer interface [polypeptide binding]; other site
859656004954	phosphorylation site [posttranslational modification]
859656004955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656004956	ATP binding site [chemical binding]; other site
859656004957	Mg2+ binding site [ion binding]; other site
859656004958	G-X-G motif; other site
859656004959	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
859656004960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656004961	active site
859656004962	phosphorylation site [posttranslational modification]
859656004963	intermolecular recognition site; other site
859656004964	dimerization interface [polypeptide binding]; other site
859656004965	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656004966	DNA binding site [nucleotide binding]
859656004967	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656004968	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656004969	trimer interface [polypeptide binding]; other site
859656004970	eyelet of channel; other site
859656004971	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
859656004972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656004973	Walker A/P-loop; other site
859656004974	ATP binding site [chemical binding]; other site
859656004975	Q-loop/lid; other site
859656004976	ABC transporter signature motif; other site
859656004977	Walker B; other site
859656004978	D-loop; other site
859656004979	H-loop/switch region; other site
859656004980	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656004981	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
859656004982	TM-ABC transporter signature motif; other site
859656004983	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
859656004984	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
859656004985	zinc binding site [ion binding]; other site
859656004986	putative ligand binding site [chemical binding]; other site
859656004987	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
859656004988	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859656004989	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
859656004990	intracellular septation protein A; Reviewed; Region: PRK00259
859656004991	methionine sulfoxide reductase B; Provisional; Region: PRK00222
859656004992	SelR domain; Region: SelR; pfam01641
859656004993	Uncharacterized conserved protein [Function unknown]; Region: COG0397
859656004994	hypothetical protein; Validated; Region: PRK00029
859656004995	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
859656004996	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
859656004997	dimer interface [polypeptide binding]; other site
859656004998	acyl-activating enzyme (AAE) consensus motif; other site
859656004999	putative active site [active]
859656005000	AMP binding site [chemical binding]; other site
859656005001	putative CoA binding site [chemical binding]; other site
859656005002	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656005003	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
859656005004	putative ligand binding site [chemical binding]; other site
859656005005	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656005006	TM-ABC transporter signature motif; other site
859656005007	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656005008	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656005009	TM-ABC transporter signature motif; other site
859656005010	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859656005011	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656005012	Walker A/P-loop; other site
859656005013	ATP binding site [chemical binding]; other site
859656005014	Q-loop/lid; other site
859656005015	ABC transporter signature motif; other site
859656005016	Walker B; other site
859656005017	D-loop; other site
859656005018	H-loop/switch region; other site
859656005019	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859656005020	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656005021	Walker A/P-loop; other site
859656005022	ATP binding site [chemical binding]; other site
859656005023	Q-loop/lid; other site
859656005024	ABC transporter signature motif; other site
859656005025	Walker B; other site
859656005026	D-loop; other site
859656005027	H-loop/switch region; other site
859656005028	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859656005029	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
859656005030	Interdomain contacts; other site
859656005031	Cytokine receptor motif; other site
859656005032	lysine transporter; Provisional; Region: PRK10836
859656005033	lysine transporter; Provisional; Region: PRK10836
859656005034	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656005035	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
859656005036	substrate binding site [chemical binding]; other site
859656005037	oxyanion hole (OAH) forming residues; other site
859656005038	trimer interface [polypeptide binding]; other site
859656005039	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859656005040	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859656005041	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859656005042	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
859656005043	Isochorismatase family; Region: Isochorismatase; pfam00857
859656005044	catalytic triad [active]
859656005045	metal binding site [ion binding]; metal-binding site
859656005046	conserved cis-peptide bond; other site
859656005047	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
859656005048	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859656005049	dimer interface [polypeptide binding]; other site
859656005050	active site
859656005051	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656005052	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
859656005053	FAD binding site [chemical binding]; other site
859656005054	substrate binding site [chemical binding]; other site
859656005055	catalytic residues [active]
859656005056	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
859656005057	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
859656005058	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656005059	NAD(P) binding site [chemical binding]; other site
859656005060	active site
859656005061	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859656005062	CoenzymeA binding site [chemical binding]; other site
859656005063	subunit interaction site [polypeptide binding]; other site
859656005064	PHB binding site; other site
859656005065	Beta-lactamase; Region: Beta-lactamase; pfam00144
859656005066	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
859656005067	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
859656005068	Prostaglandin dehydrogenases; Region: PGDH; cd05288
859656005069	NAD(P) binding site [chemical binding]; other site
859656005070	substrate binding site [chemical binding]; other site
859656005071	dimer interface [polypeptide binding]; other site
859656005072	hypothetical protein; Provisional; Region: PRK06208
859656005073	intersubunit interface [polypeptide binding]; other site
859656005074	active site
859656005075	Zn2+ binding site [ion binding]; other site
859656005076	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656005077	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
859656005078	C-terminal domain interface [polypeptide binding]; other site
859656005079	GSH binding site (G-site) [chemical binding]; other site
859656005080	dimer interface [polypeptide binding]; other site
859656005081	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
859656005082	N-terminal domain interface [polypeptide binding]; other site
859656005083	hypothetical protein; Provisional; Region: PRK06194
859656005084	classical (c) SDRs; Region: SDR_c; cd05233
859656005085	NAD(P) binding site [chemical binding]; other site
859656005086	active site
859656005087	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859656005088	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
859656005089	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
859656005090	putative active site [active]
859656005091	metal binding site [ion binding]; metal-binding site
859656005092	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859656005093	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859656005094	substrate binding pocket [chemical binding]; other site
859656005095	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859656005096	active site
859656005097	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
859656005098	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656005099	Coenzyme A binding pocket [chemical binding]; other site
859656005100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656005101	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859656005102	NAD(P) binding site [chemical binding]; other site
859656005103	active site
859656005104	Uncharacterized conserved protein [Function unknown]; Region: COG3332
859656005105	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
859656005106	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
859656005107	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
859656005108	YceG-like family; Region: YceG; pfam02618
859656005109	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
859656005110	dimerization interface [polypeptide binding]; other site
859656005111	thymidylate kinase; Validated; Region: tmk; PRK00698
859656005112	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
859656005113	TMP-binding site; other site
859656005114	ATP-binding site [chemical binding]; other site
859656005115	DNA polymerase III subunit delta'; Validated; Region: PRK06964
859656005116	DNA polymerase III subunit delta'; Validated; Region: PRK08485
859656005117	PilZ domain; Region: PilZ; cl01260
859656005118	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
859656005119	active site
859656005120	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656005121	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656005122	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656005123	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656005124	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
859656005125	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859656005126	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859656005127	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656005128	DNA binding site [nucleotide binding]
859656005129	domain linker motif; other site
859656005130	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
859656005131	putative dimerization interface [polypeptide binding]; other site
859656005132	putative ligand binding site [chemical binding]; other site
859656005133	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
859656005134	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
859656005135	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
859656005136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656005137	dimer interface [polypeptide binding]; other site
859656005138	conserved gate region; other site
859656005139	putative PBP binding loops; other site
859656005140	ABC-ATPase subunit interface; other site
859656005141	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
859656005142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656005143	dimer interface [polypeptide binding]; other site
859656005144	conserved gate region; other site
859656005145	putative PBP binding loops; other site
859656005146	ABC-ATPase subunit interface; other site
859656005147	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
859656005148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656005149	Walker A/P-loop; other site
859656005150	ATP binding site [chemical binding]; other site
859656005151	Q-loop/lid; other site
859656005152	ABC transporter signature motif; other site
859656005153	Walker B; other site
859656005154	D-loop; other site
859656005155	H-loop/switch region; other site
859656005156	TOBE domain; Region: TOBE_2; pfam08402
859656005157	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
859656005158	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
859656005159	active site
859656005160	metal binding site [ion binding]; metal-binding site
859656005161	hexamer interface [polypeptide binding]; other site
859656005162	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
859656005163	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
859656005164	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
859656005165	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656005166	putative C-terminal domain interface [polypeptide binding]; other site
859656005167	putative GSH binding site (G-site) [chemical binding]; other site
859656005168	putative dimer interface [polypeptide binding]; other site
859656005169	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
859656005170	putative N-terminal domain interface [polypeptide binding]; other site
859656005171	putative dimer interface [polypeptide binding]; other site
859656005172	putative substrate binding pocket (H-site) [chemical binding]; other site
859656005173	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
859656005174	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
859656005175	tetramer interface [polypeptide binding]; other site
859656005176	TPP-binding site [chemical binding]; other site
859656005177	heterodimer interface [polypeptide binding]; other site
859656005178	phosphorylation loop region [posttranslational modification]
859656005179	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
859656005180	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
859656005181	alpha subunit interface [polypeptide binding]; other site
859656005182	TPP binding site [chemical binding]; other site
859656005183	heterodimer interface [polypeptide binding]; other site
859656005184	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
859656005185	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
859656005186	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859656005187	E3 interaction surface; other site
859656005188	lipoyl attachment site [posttranslational modification]; other site
859656005189	e3 binding domain; Region: E3_binding; pfam02817
859656005190	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
859656005191	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005192	Substrate binding site [chemical binding]; other site
859656005193	Leucine rich repeat; Region: LRR_8; pfam13855
859656005194	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005195	Leucine-rich repeats; other site
859656005196	Substrate binding site [chemical binding]; other site
859656005197	Leucine rich repeat; Region: LRR_8; pfam13855
859656005198	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005199	Leucine-rich repeats; other site
859656005200	Substrate binding site [chemical binding]; other site
859656005201	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005202	Leucine-rich repeats; other site
859656005203	Leucine rich repeat; Region: LRR_8; pfam13855
859656005204	Substrate binding site [chemical binding]; other site
859656005205	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
859656005206	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
859656005207	conserved cys residue [active]
859656005208	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656005209	Domain of unknown function DUF29; Region: DUF29; pfam01724
859656005210	Zonular occludens toxin (Zot); Region: Zot; cl17485
859656005211	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
859656005212	Replication initiation factor; Region: Rep_trans; pfam02486
859656005213	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656005214	non-specific DNA binding site [nucleotide binding]; other site
859656005215	sequence-specific DNA binding site [nucleotide binding]; other site
859656005216	salt bridge; other site
859656005217	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656005218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656005219	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
859656005220	putative dimerization interface [polypeptide binding]; other site
859656005221	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
859656005222	Coenzyme A transferase; Region: CoA_trans; cl17247
859656005223	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
859656005224	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
859656005225	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
859656005226	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
859656005227	Malonate transporter MadL subunit; Region: MadL; cl04273
859656005228	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
859656005229	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
859656005230	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
859656005231	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859656005232	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
859656005233	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
859656005234	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656005235	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656005236	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
859656005237	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656005238	NAD(P) binding site [chemical binding]; other site
859656005239	active site
859656005240	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859656005241	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656005242	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656005243	LysR substrate binding domain; Region: LysR_substrate; pfam03466
859656005244	dimerization interface [polypeptide binding]; other site
859656005245	Predicted amidohydrolase [General function prediction only]; Region: COG0388
859656005246	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
859656005247	putative active site [active]
859656005248	catalytic triad [active]
859656005249	putative dimer interface [polypeptide binding]; other site
859656005250	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
859656005251	Moco binding site; other site
859656005252	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
859656005253	metal coordination site [ion binding]; other site
859656005254	cystathionine beta-lyase; Provisional; Region: PRK07050
859656005255	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859656005256	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656005257	catalytic residue [active]
859656005258	Uncharacterized conserved protein [Function unknown]; Region: COG5514
859656005259	heme-binding site [chemical binding]; other site
859656005260	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
859656005261	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
859656005262	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
859656005263	Protein of unknown function (DUF817); Region: DUF817; pfam05675
859656005264	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
859656005265	AAA domain; Region: AAA_26; pfam13500
859656005266	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
859656005267	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
859656005268	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656005269	catalytic residue [active]
859656005270	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
859656005271	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656005272	inhibitor-cofactor binding pocket; inhibition site
859656005273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656005274	catalytic residue [active]
859656005275	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
859656005276	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
859656005277	putative NAD(P) binding site [chemical binding]; other site
859656005278	active site
859656005279	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
859656005280	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656005281	catalytic loop [active]
859656005282	iron binding site [ion binding]; other site
859656005283	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
859656005284	FAD binding pocket [chemical binding]; other site
859656005285	FAD binding motif [chemical binding]; other site
859656005286	phosphate binding motif [ion binding]; other site
859656005287	beta-alpha-beta structure motif; other site
859656005288	NAD binding pocket [chemical binding]; other site
859656005289	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
859656005290	inter-subunit interface; other site
859656005291	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
859656005292	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
859656005293	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
859656005294	putative alpha subunit interface [polypeptide binding]; other site
859656005295	putative active site [active]
859656005296	putative substrate binding site [chemical binding]; other site
859656005297	Fe binding site [ion binding]; other site
859656005298	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
859656005299	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
859656005300	dimer interface [polypeptide binding]; other site
859656005301	active site
859656005302	Muconolactone delta-isomerase; Region: MIase; cl01992
859656005303	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
859656005304	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
859656005305	octamer interface [polypeptide binding]; other site
859656005306	active site
859656005307	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656005308	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656005309	dimerization interface [polypeptide binding]; other site
859656005310	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
859656005311	Transglycosylase; Region: Transgly; cl17702
859656005312	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
859656005313	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656005314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656005315	putative DNA binding site [nucleotide binding]; other site
859656005316	putative Zn2+ binding site [ion binding]; other site
859656005317	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
859656005318	dimer interface [polypeptide binding]; other site
859656005319	FMN binding site [chemical binding]; other site
859656005320	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
859656005321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656005322	putative substrate translocation pore; other site
859656005323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656005324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656005325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656005326	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656005327	putative effector binding pocket; other site
859656005328	dimerization interface [polypeptide binding]; other site
859656005329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
859656005330	CreA protein; Region: CreA; pfam05981
859656005331	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859656005332	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859656005333	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859656005334	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
859656005335	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859656005336	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
859656005337	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
859656005338	MoxR-like ATPases [General function prediction only]; Region: COG0714
859656005339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656005340	Walker A motif; other site
859656005341	ATP binding site [chemical binding]; other site
859656005342	Walker B motif; other site
859656005343	arginine finger; other site
859656005344	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
859656005345	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
859656005346	metal ion-dependent adhesion site (MIDAS); other site
859656005347	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
859656005348	putative hydrophobic ligand binding site [chemical binding]; other site
859656005349	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
859656005350	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
859656005351	XdhC Rossmann domain; Region: XdhC_C; pfam13478
859656005352	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859656005353	fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236
859656005354	putative NAD(P) binding site [chemical binding]; other site
859656005355	active site
859656005356	putative substrate binding site [chemical binding]; other site
859656005357	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
859656005358	MgtC family; Region: MgtC; pfam02308
859656005359	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656005360	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
859656005361	dimer interface [polypeptide binding]; other site
859656005362	ligand binding site [chemical binding]; other site
859656005363	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656005364	dimerization interface [polypeptide binding]; other site
859656005365	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656005366	dimer interface [polypeptide binding]; other site
859656005367	putative CheW interface [polypeptide binding]; other site
859656005368	Evidence 4 : Homologs of previously reported genes of unknown function
859656005369	Evidence 4 : Homologs of previously reported genes of unknown function
859656005370	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
859656005371	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
859656005372	Predicted Fe-S protein [General function prediction only]; Region: COG3313
859656005373	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
859656005374	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656005375	NAD binding site [chemical binding]; other site
859656005376	catalytic residues [active]
859656005377	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
859656005378	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656005379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656005380	ABC transporter; Region: ABC_tran_2; pfam12848
859656005381	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656005382	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
859656005383	dimer interface [polypeptide binding]; other site
859656005384	catalytic triad [active]
859656005385	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
859656005386	nucleoside/Zn binding site; other site
859656005387	dimer interface [polypeptide binding]; other site
859656005388	catalytic motif [active]
859656005389	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
859656005390	active site
859656005391	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
859656005392	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
859656005393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656005394	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656005395	non-specific DNA binding site [nucleotide binding]; other site
859656005396	salt bridge; other site
859656005397	sequence-specific DNA binding site [nucleotide binding]; other site
859656005398	HipA N-terminal domain; Region: couple_hipA; TIGR03071
859656005399	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
859656005400	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859656005401	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859656005402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656005403	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656005404	putative substrate translocation pore; other site
859656005405	Evidence 2b : Function of strongly homologous gene; Product type r : regulator
859656005406	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
859656005407	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
859656005408	catalytic residues [active]
859656005409	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
859656005410	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
859656005411	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
859656005412	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
859656005413	heterodimer interface [polypeptide binding]; other site
859656005414	active site
859656005415	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
859656005416	heterodimer interface [polypeptide binding]; other site
859656005417	multimer interface [polypeptide binding]; other site
859656005418	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
859656005419	active site
859656005420	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
859656005421	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656005422	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
859656005423	putative dimerization interface [polypeptide binding]; other site
859656005424	Integrase core domain; Region: rve; pfam00665
859656005425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859656005426	Integrase core domain; Region: rve_3; pfam13683
859656005427	GMP synthase; Reviewed; Region: guaA; PRK00074
859656005428	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
859656005429	AMP/PPi binding site [chemical binding]; other site
859656005430	candidate oxyanion hole; other site
859656005431	catalytic triad [active]
859656005432	potential glutamine specificity residues [chemical binding]; other site
859656005433	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
859656005434	ATP Binding subdomain [chemical binding]; other site
859656005435	Ligand Binding sites [chemical binding]; other site
859656005436	Dimerization subdomain; other site
859656005437	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
859656005438	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
859656005439	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
859656005440	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
859656005441	active site
859656005442	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656005443	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
859656005444	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
859656005445	putative coenzyme Q binding site [chemical binding]; other site
859656005446	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
859656005447	SmpB-tmRNA interface; other site
859656005448	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
859656005449	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
859656005450	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
859656005451	phosphoenolpyruvate synthase; Validated; Region: PRK06464
859656005452	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
859656005453	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859656005454	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859656005455	PEP synthetase regulatory protein; Provisional; Region: PRK05339
859656005456	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
859656005457	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
859656005458	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
859656005459	RNA/DNA hybrid binding site [nucleotide binding]; other site
859656005460	active site
859656005461	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
859656005462	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
859656005463	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
859656005464	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
859656005465	active site
859656005466	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
859656005467	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
859656005468	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
859656005469	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
859656005470	trimer interface [polypeptide binding]; other site
859656005471	active site
859656005472	UDP-GlcNAc binding site [chemical binding]; other site
859656005473	lipid binding site [chemical binding]; lipid-binding site
859656005474	periplasmic chaperone; Provisional; Region: PRK10780
859656005475	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
859656005476	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
859656005477	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859656005478	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859656005479	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859656005480	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859656005481	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
859656005482	Surface antigen; Region: Bac_surface_Ag; pfam01103
859656005483	zinc metallopeptidase RseP; Provisional; Region: PRK10779
859656005484	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
859656005485	active site
859656005486	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
859656005487	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
859656005488	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
859656005489	putative substrate binding region [chemical binding]; other site
859656005490	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
859656005491	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
859656005492	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
859656005493	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
859656005494	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
859656005495	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
859656005496	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
859656005497	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
859656005498	catalytic residue [active]
859656005499	putative FPP diphosphate  binding site; other site
859656005500	putative FPP binding hydrophobic cleft; other site
859656005501	dimer interface [polypeptide binding]; other site
859656005502	putative IPP diphosphate binding site; other site
859656005503	ribosome recycling factor; Reviewed; Region: frr; PRK00083
859656005504	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
859656005505	hinge region; other site
859656005506	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
859656005507	putative nucleotide binding site [chemical binding]; other site
859656005508	uridine monophosphate binding site [chemical binding]; other site
859656005509	homohexameric interface [polypeptide binding]; other site
859656005510	elongation factor Ts; Provisional; Region: tsf; PRK09377
859656005511	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
859656005512	Elongation factor TS; Region: EF_TS; pfam00889
859656005513	Elongation factor TS; Region: EF_TS; pfam00889
859656005514	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
859656005515	rRNA interaction site [nucleotide binding]; other site
859656005516	S8 interaction site; other site
859656005517	putative laminin-1 binding site; other site
859656005518	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
859656005519	active site
859656005520	PII uridylyl-transferase; Provisional; Region: PRK03059
859656005521	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
859656005522	metal binding triad; other site
859656005523	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
859656005524	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656005525	Zn2+ binding site [ion binding]; other site
859656005526	Mg2+ binding site [ion binding]; other site
859656005527	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
859656005528	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
859656005529	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
859656005530	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656005531	RNA binding surface [nucleotide binding]; other site
859656005532	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
859656005533	active site
859656005534	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
859656005535	active site
859656005536	catalytic residues [active]
859656005537	metal binding site [ion binding]; metal-binding site
859656005538	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
859656005539	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
859656005540	nucleotide binding pocket [chemical binding]; other site
859656005541	K-X-D-G motif; other site
859656005542	catalytic site [active]
859656005543	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
859656005544	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
859656005545	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
859656005546	Dimer interface [polypeptide binding]; other site
859656005547	BRCT sequence motif; other site
859656005548	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
859656005549	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
859656005550	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
859656005551	Walker A/P-loop; other site
859656005552	ATP binding site [chemical binding]; other site
859656005553	Q-loop/lid; other site
859656005554	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
859656005555	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
859656005556	Q-loop/lid; other site
859656005557	ABC transporter signature motif; other site
859656005558	Walker B; other site
859656005559	D-loop; other site
859656005560	H-loop/switch region; other site
859656005561	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
859656005562	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656005563	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
859656005564	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656005565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656005566	homodimer interface [polypeptide binding]; other site
859656005567	catalytic residue [active]
859656005568	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
859656005569	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
859656005570	trimer interface [polypeptide binding]; other site
859656005571	active site
859656005572	substrate binding site [chemical binding]; other site
859656005573	CoA binding site [chemical binding]; other site
859656005574	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
859656005575	ArsC family; Region: ArsC; pfam03960
859656005576	putative catalytic residues [active]
859656005577	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
859656005578	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
859656005579	metal binding site [ion binding]; metal-binding site
859656005580	dimer interface [polypeptide binding]; other site
859656005581	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
859656005582	putative active site [active]
859656005583	putative metal binding residues [ion binding]; other site
859656005584	signature motif; other site
859656005585	putative triphosphate binding site [ion binding]; other site
859656005586	dimer interface [polypeptide binding]; other site
859656005587	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
859656005588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656005589	S-adenosylmethionine binding site [chemical binding]; other site
859656005590	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
859656005591	SxDxEG motif; other site
859656005592	active site
859656005593	metal binding site [ion binding]; metal-binding site
859656005594	homopentamer interface [polypeptide binding]; other site
859656005595	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
859656005596	homodimer interface [polypeptide binding]; other site
859656005597	homotetramer interface [polypeptide binding]; other site
859656005598	active site pocket [active]
859656005599	cleavage site
859656005600	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
859656005601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656005602	dimer interface [polypeptide binding]; other site
859656005603	conserved gate region; other site
859656005604	putative PBP binding loops; other site
859656005605	ABC-ATPase subunit interface; other site
859656005606	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
859656005607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656005608	dimer interface [polypeptide binding]; other site
859656005609	conserved gate region; other site
859656005610	putative PBP binding loops; other site
859656005611	ABC-ATPase subunit interface; other site
859656005612	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
859656005613	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
859656005614	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
859656005615	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656005616	Walker A/P-loop; other site
859656005617	ATP binding site [chemical binding]; other site
859656005618	Q-loop/lid; other site
859656005619	ABC transporter signature motif; other site
859656005620	Walker B; other site
859656005621	D-loop; other site
859656005622	H-loop/switch region; other site
859656005623	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
859656005624	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656005625	Walker A/P-loop; other site
859656005626	ATP binding site [chemical binding]; other site
859656005627	Q-loop/lid; other site
859656005628	ABC transporter signature motif; other site
859656005629	Walker B; other site
859656005630	D-loop; other site
859656005631	H-loop/switch region; other site
859656005632	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859656005633	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
859656005634	catalytic nucleophile [active]
859656005635	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859656005636	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859656005637	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859656005638	putative active site [active]
859656005639	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
859656005640	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656005641	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656005642	ABC transporter; Region: ABC_tran_2; pfam12848
859656005643	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656005644	formyl-coenzyme A transferase; Provisional; Region: PRK05398
859656005645	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859656005646	disulfide bond formation protein B; Provisional; Region: PRK02110
859656005647	DNA repair protein RadA; Provisional; Region: PRK11823
859656005648	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
859656005649	Walker A motif/ATP binding site; other site
859656005650	ATP binding site [chemical binding]; other site
859656005651	Walker B motif; other site
859656005652	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
859656005653	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
859656005654	alanine racemase; Reviewed; Region: dadX; PRK03646
859656005655	active site
859656005656	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656005657	substrate binding site [chemical binding]; other site
859656005658	catalytic residues [active]
859656005659	dimer interface [polypeptide binding]; other site
859656005660	lysophospholipid transporter LplT; Provisional; Region: PRK11195
859656005661	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
859656005662	Fe-S cluster binding site [ion binding]; other site
859656005663	active site
859656005664	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656005665	Coenzyme A binding pocket [chemical binding]; other site
859656005666	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
859656005667	Glycoprotease family; Region: Peptidase_M22; pfam00814
859656005668	Acyl-CoA-binding protein [Lipid metabolism]; Region: ACB; COG4281
859656005669	acyl-CoA binding pocket [chemical binding]; other site
859656005670	CoA binding site [chemical binding]; other site
859656005671	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
859656005672	putative hydrophobic ligand binding site [chemical binding]; other site
859656005673	malate synthase A; Region: malate_syn_A; TIGR01344
859656005674	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
859656005675	active site
859656005676	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
859656005677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656005678	motif II; other site
859656005679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656005680	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656005681	putative effector binding pocket; other site
859656005682	dimerization interface [polypeptide binding]; other site
859656005683	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656005684	Ligand Binding Site [chemical binding]; other site
859656005685	isocitrate lyase; Provisional; Region: PRK15063
859656005686	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
859656005687	tetramer interface [polypeptide binding]; other site
859656005688	active site
859656005689	Mg2+/Mn2+ binding site [ion binding]; other site
859656005690	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005691	Leucine-rich repeats; other site
859656005692	Substrate binding site [chemical binding]; other site
859656005693	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005694	Leucine-rich repeats; other site
859656005695	Substrate binding site [chemical binding]; other site
859656005696	Leucine rich repeat; Region: LRR_8; pfam13855
859656005697	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656005698	Leucine-rich repeats; other site
859656005699	Substrate binding site [chemical binding]; other site
859656005700	Leucine rich repeat; Region: LRR_8; pfam13855
859656005701	Leucine rich repeat; Region: LRR_8; pfam13855
859656005702	Leucine rich repeat; Region: LRR_8; pfam13855
859656005703	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
859656005704	putative active site pocket [active]
859656005705	dimerization interface [polypeptide binding]; other site
859656005706	putative catalytic residue [active]
859656005707	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
859656005708	thiamine pyrophosphate protein; Validated; Region: PRK08199
859656005709	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859656005710	PYR/PP interface [polypeptide binding]; other site
859656005711	dimer interface [polypeptide binding]; other site
859656005712	TPP binding site [chemical binding]; other site
859656005713	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859656005714	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
859656005715	TPP-binding site [chemical binding]; other site
859656005716	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
859656005717	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656005718	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
859656005719	substrate binding site [chemical binding]; other site
859656005720	dimerization interface [polypeptide binding]; other site
859656005721	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
859656005722	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
859656005723	Walker A/P-loop; other site
859656005724	ATP binding site [chemical binding]; other site
859656005725	Q-loop/lid; other site
859656005726	ABC transporter signature motif; other site
859656005727	Walker B; other site
859656005728	D-loop; other site
859656005729	H-loop/switch region; other site
859656005730	TOBE-like domain; Region: TOBE_3; pfam12857
859656005731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656005732	dimer interface [polypeptide binding]; other site
859656005733	conserved gate region; other site
859656005734	putative PBP binding loops; other site
859656005735	ABC-ATPase subunit interface; other site
859656005736	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
859656005737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656005738	dimer interface [polypeptide binding]; other site
859656005739	conserved gate region; other site
859656005740	putative PBP binding loops; other site
859656005741	ABC-ATPase subunit interface; other site
859656005742	Serine hydrolase; Region: Ser_hydrolase; pfam06821
859656005743	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656005744	EAL domain; Region: EAL; pfam00563
859656005745	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
859656005746	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10506196, 16204527; Product type e : enzyme
859656005747	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
859656005748	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859656005749	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
859656005750	Clp amino terminal domain; Region: Clp_N; pfam02861
859656005751	Clp amino terminal domain; Region: Clp_N; pfam02861
859656005752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656005753	Walker A motif; other site
859656005754	ATP binding site [chemical binding]; other site
859656005755	Walker B motif; other site
859656005756	arginine finger; other site
859656005757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656005758	Walker A motif; other site
859656005759	ATP binding site [chemical binding]; other site
859656005760	Walker B motif; other site
859656005761	arginine finger; other site
859656005762	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
859656005763	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
859656005764	chromosome condensation membrane protein; Provisional; Region: PRK14196
859656005765	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
859656005766	MoaE homodimer interface [polypeptide binding]; other site
859656005767	MoaD interaction [polypeptide binding]; other site
859656005768	active site residues [active]
859656005769	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
859656005770	MoaE interaction surface [polypeptide binding]; other site
859656005771	MoeB interaction surface [polypeptide binding]; other site
859656005772	thiocarboxylated glycine; other site
859656005773	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
859656005774	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
859656005775	dimer interface [polypeptide binding]; other site
859656005776	putative functional site; other site
859656005777	putative MPT binding site; other site
859656005778	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
859656005779	putative uracil binding site [chemical binding]; other site
859656005780	putative active site [active]
859656005781	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
859656005782	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
859656005783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656005784	catalytic residue [active]
859656005785	homoserine dehydrogenase; Provisional; Region: PRK06349
859656005786	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
859656005787	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
859656005788	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
859656005789	aminotransferase AlaT; Validated; Region: PRK09265
859656005790	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656005791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656005792	homodimer interface [polypeptide binding]; other site
859656005793	catalytic residue [active]
859656005794	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
859656005795	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859656005796	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859656005797	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
859656005798	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
859656005799	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
859656005800	inhibitor-cofactor binding pocket; inhibition site
859656005801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656005802	catalytic residue [active]
859656005803	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
859656005804	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
859656005805	Ligand binding site; other site
859656005806	Putative Catalytic site; other site
859656005807	DXD motif; other site
859656005808	putative formyltransferase; Provisional; Region: PRK06988
859656005809	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
859656005810	active site
859656005811	substrate binding site [chemical binding]; other site
859656005812	cosubstrate binding site; other site
859656005813	catalytic site [active]
859656005814	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
859656005815	active site
859656005816	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
859656005817	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
859656005818	NAD binding site [chemical binding]; other site
859656005819	substrate binding site [chemical binding]; other site
859656005820	active site
859656005821	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
859656005822	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
859656005823	putative active site [active]
859656005824	putative catalytic site [active]
859656005825	putative Zn binding site [ion binding]; other site
859656005826	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
859656005827	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656005828	catalytic triad [active]
859656005829	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
859656005830	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
859656005831	putative active site [active]
859656005832	PhoH-like protein; Region: PhoH; pfam02562
859656005833	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
859656005834	NlpC/P60 family; Region: NLPC_P60; pfam00877
859656005835	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
859656005836	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
859656005837	replicative DNA helicase; Provisional; Region: PRK07004
859656005838	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
859656005839	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
859656005840	Walker A motif; other site
859656005841	ATP binding site [chemical binding]; other site
859656005842	Walker B motif; other site
859656005843	DNA binding loops [nucleotide binding]
859656005844	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
859656005845	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
859656005846	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
859656005847	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
859656005848	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
859656005849	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
859656005850	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
859656005851	active site
859656005852	homotetramer interface [polypeptide binding]; other site
859656005853	homodimer interface [polypeptide binding]; other site
859656005854	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
859656005855	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
859656005856	FAD binding pocket [chemical binding]; other site
859656005857	FAD binding motif [chemical binding]; other site
859656005858	phosphate binding motif [ion binding]; other site
859656005859	beta-alpha-beta structure motif; other site
859656005860	NAD binding pocket [chemical binding]; other site
859656005861	LexA repressor; Validated; Region: PRK00215
859656005862	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
859656005863	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
859656005864	Catalytic site [active]
859656005865	hypothetical protein; Provisional; Region: PRK06156
859656005866	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
859656005867	active site
859656005868	metal binding site [ion binding]; metal-binding site
859656005869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
859656005870	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
859656005871	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
859656005872	FMN binding site [chemical binding]; other site
859656005873	active site
859656005874	catalytic residues [active]
859656005875	substrate binding site [chemical binding]; other site
859656005876	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
859656005877	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656005878	substrate binding site [chemical binding]; other site
859656005879	oxyanion hole (OAH) forming residues; other site
859656005880	trimer interface [polypeptide binding]; other site
859656005881	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
859656005882	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
859656005883	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
859656005884	G1 box; other site
859656005885	putative GEF interaction site [polypeptide binding]; other site
859656005886	GTP/Mg2+ binding site [chemical binding]; other site
859656005887	Switch I region; other site
859656005888	G2 box; other site
859656005889	G3 box; other site
859656005890	Switch II region; other site
859656005891	G4 box; other site
859656005892	G5 box; other site
859656005893	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
859656005894	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
859656005895	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656005896	MarR family; Region: MarR; pfam01047
859656005897	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656005898	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
859656005899	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
859656005900	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656005901	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
859656005902	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656005903	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859656005904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656005905	putative substrate translocation pore; other site
859656005906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656005907	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
859656005908	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
859656005909	RNA binding site [nucleotide binding]; other site
859656005910	active site
859656005911	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
859656005912	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
859656005913	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
859656005914	translation initiation factor IF-2; Region: IF-2; TIGR00487
859656005915	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
859656005916	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
859656005917	G1 box; other site
859656005918	putative GEF interaction site [polypeptide binding]; other site
859656005919	GTP/Mg2+ binding site [chemical binding]; other site
859656005920	Switch I region; other site
859656005921	G2 box; other site
859656005922	G3 box; other site
859656005923	Switch II region; other site
859656005924	G4 box; other site
859656005925	G5 box; other site
859656005926	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
859656005927	Translation-initiation factor 2; Region: IF-2; pfam11987
859656005928	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
859656005929	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
859656005930	NusA N-terminal domain; Region: NusA_N; pfam08529
859656005931	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
859656005932	RNA binding site [nucleotide binding]; other site
859656005933	homodimer interface [polypeptide binding]; other site
859656005934	NusA-like KH domain; Region: KH_5; pfam13184
859656005935	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
859656005936	G-X-X-G motif; other site
859656005937	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
859656005938	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
859656005939	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
859656005940	Sm and related proteins; Region: Sm_like; cl00259
859656005941	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
859656005942	putative oligomer interface [polypeptide binding]; other site
859656005943	putative RNA binding site [nucleotide binding]; other site
859656005944	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
859656005945	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656005946	RNA binding surface [nucleotide binding]; other site
859656005947	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
859656005948	probable active site [active]
859656005949	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
859656005950	Uncharacterized conserved protein [Function unknown]; Region: COG2836
859656005951	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859656005952	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
859656005953	ligand binding site [chemical binding]; other site
859656005954	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859656005955	putative switch regulator; other site
859656005956	non-specific DNA interactions [nucleotide binding]; other site
859656005957	DNA binding site [nucleotide binding]
859656005958	sequence specific DNA binding site [nucleotide binding]; other site
859656005959	putative cAMP binding site [chemical binding]; other site
859656005960	FixH; Region: FixH; pfam05751
859656005961	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
859656005962	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
859656005963	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
859656005964	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
859656005965	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
859656005966	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
859656005967	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
859656005968	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
859656005969	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
859656005970	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
859656005971	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
859656005972	Low-spin heme binding site [chemical binding]; other site
859656005973	Putative water exit pathway; other site
859656005974	Binuclear center (active site) [active]
859656005975	Putative proton exit pathway; other site
859656005976	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
859656005977	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
859656005978	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
859656005979	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
859656005980	metal-binding site [ion binding]
859656005981	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859656005982	Soluble P-type ATPase [General function prediction only]; Region: COG4087
859656005983	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
859656005984	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
859656005985	Predicted ATPase [General function prediction only]; Region: COG1485
859656005986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656005987	Walker B; other site
859656005988	D-loop; other site
859656005989	H-loop/switch region; other site
859656005990	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
859656005991	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656005992	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859656005993	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6376124; Product type e : enzyme
859656005994	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6376124; Product type e : enzyme
859656005995	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
859656005996	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
859656005997	TPP-binding site [chemical binding]; other site
859656005998	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
859656005999	dimer interface [polypeptide binding]; other site
859656006000	PYR/PP interface [polypeptide binding]; other site
859656006001	TPP binding site [chemical binding]; other site
859656006002	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
859656006003	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
859656006004	putative active site [active]
859656006005	catalytic site [active]
859656006006	putative metal binding site [ion binding]; other site
859656006007	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
859656006008	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
859656006009	Walker A/P-loop; other site
859656006010	ATP binding site [chemical binding]; other site
859656006011	Q-loop/lid; other site
859656006012	ABC transporter signature motif; other site
859656006013	Walker B; other site
859656006014	D-loop; other site
859656006015	H-loop/switch region; other site
859656006016	TOBE domain; Region: TOBE_2; pfam08402
859656006017	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
859656006018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656006019	dimer interface [polypeptide binding]; other site
859656006020	conserved gate region; other site
859656006021	putative PBP binding loops; other site
859656006022	ABC-ATPase subunit interface; other site
859656006023	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
859656006024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656006025	dimer interface [polypeptide binding]; other site
859656006026	conserved gate region; other site
859656006027	putative PBP binding loops; other site
859656006028	ABC-ATPase subunit interface; other site
859656006029	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
859656006030	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859656006031	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
859656006032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656006033	active site
859656006034	motif I; other site
859656006035	motif II; other site
859656006036	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
859656006037	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
859656006038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656006039	active site
859656006040	phosphorylation site [posttranslational modification]
859656006041	intermolecular recognition site; other site
859656006042	dimerization interface [polypeptide binding]; other site
859656006043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656006044	Walker A motif; other site
859656006045	ATP binding site [chemical binding]; other site
859656006046	Walker B motif; other site
859656006047	arginine finger; other site
859656006048	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656006049	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
859656006050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656006051	putative active site [active]
859656006052	heme pocket [chemical binding]; other site
859656006053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656006054	dimer interface [polypeptide binding]; other site
859656006055	phosphorylation site [posttranslational modification]
859656006056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656006057	ATP binding site [chemical binding]; other site
859656006058	Mg2+ binding site [ion binding]; other site
859656006059	G-X-G motif; other site
859656006060	glutamine synthetase; Provisional; Region: glnA; PRK09469
859656006061	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
859656006062	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
859656006063	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859656006064	active site residue [active]
859656006065	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
859656006066	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
859656006067	putative MPT binding site; other site
859656006068	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
859656006069	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
859656006070	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
859656006071	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
859656006072	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
859656006073	NodB motif; other site
859656006074	active site
859656006075	catalytic site [active]
859656006076	metal binding site [ion binding]; metal-binding site
859656006077	Uncharacterized conserved protein [Function unknown]; Region: COG3391
859656006078	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
859656006079	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
859656006080	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656006081	ATP binding site [chemical binding]; other site
859656006082	putative Mg++ binding site [ion binding]; other site
859656006083	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656006084	nucleotide binding region [chemical binding]; other site
859656006085	ATP-binding site [chemical binding]; other site
859656006086	Helicase associated domain (HA2); Region: HA2; pfam04408
859656006087	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
859656006088	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
859656006089	N-acetylglutamate synthase; Validated; Region: PRK05279
859656006090	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
859656006091	putative feedback inhibition sensing region; other site
859656006092	putative nucleotide binding site [chemical binding]; other site
859656006093	putative substrate binding site [chemical binding]; other site
859656006094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656006095	Coenzyme A binding pocket [chemical binding]; other site
859656006096	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859656006097	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859656006098	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859656006099	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
859656006100	KduI/IolB family; Region: KduI; pfam04962
859656006101	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
859656006102	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
859656006103	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
859656006104	PYR/PP interface [polypeptide binding]; other site
859656006105	dimer interface [polypeptide binding]; other site
859656006106	TPP binding site [chemical binding]; other site
859656006107	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
859656006108	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
859656006109	TPP-binding site [chemical binding]; other site
859656006110	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859656006111	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
859656006112	substrate binding site [chemical binding]; other site
859656006113	ATP binding site [chemical binding]; other site
859656006114	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
859656006115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
859656006116	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656006117	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859656006118	TM-ABC transporter signature motif; other site
859656006119	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859656006120	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
859656006121	Walker A/P-loop; other site
859656006122	ATP binding site [chemical binding]; other site
859656006123	Q-loop/lid; other site
859656006124	ABC transporter signature motif; other site
859656006125	Walker B; other site
859656006126	D-loop; other site
859656006127	H-loop/switch region; other site
859656006128	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859656006129	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
859656006130	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
859656006131	putative ligand binding site [chemical binding]; other site
859656006132	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
859656006133	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656006134	DNA binding site [nucleotide binding]
859656006135	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
859656006136	putative ligand binding site [chemical binding]; other site
859656006137	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
859656006138	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
859656006139	putative di-iron ligands [ion binding]; other site
859656006140	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
859656006141	[2Fe-2S] cluster binding site [ion binding]; other site
859656006142	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
859656006143	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
859656006144	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
859656006145	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656006146	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859656006147	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859656006148	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859656006149	putative active site [active]
859656006150	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859656006151	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859656006152	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859656006153	oxidative damage protection protein; Provisional; Region: PRK05408
859656006154	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656006155	dimerization interface [polypeptide binding]; other site
859656006156	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656006157	dimer interface [polypeptide binding]; other site
859656006158	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
859656006159	putative CheW interface [polypeptide binding]; other site
859656006160	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
859656006161	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
859656006162	Na binding site [ion binding]; other site
859656006163	putative substrate binding site [chemical binding]; other site
859656006164	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
859656006165	tetramer (dimer of dimers) interface [polypeptide binding]; other site
859656006166	active site
859656006167	dimer interface [polypeptide binding]; other site
859656006168	transaldolase-like protein; Provisional; Region: PTZ00411
859656006169	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
859656006170	active site
859656006171	dimer interface [polypeptide binding]; other site
859656006172	catalytic residue [active]
859656006173	NAD-dependent deacetylase; Provisional; Region: PRK00481
859656006174	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
859656006175	NAD+ binding site [chemical binding]; other site
859656006176	substrate binding site [chemical binding]; other site
859656006177	Zn binding site [ion binding]; other site
859656006178	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
859656006179	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
859656006180	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
859656006181	ribonuclease R; Region: RNase_R; TIGR02063
859656006182	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
859656006183	RNB domain; Region: RNB; pfam00773
859656006184	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
859656006185	RNA binding site [nucleotide binding]; other site
859656006186	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
859656006187	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656006188	active site
859656006189	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
859656006190	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
859656006191	GDP-binding site [chemical binding]; other site
859656006192	ACT binding site; other site
859656006193	IMP binding site; other site
859656006194	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
859656006195	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
859656006196	dimer interface [polypeptide binding]; other site
859656006197	motif 1; other site
859656006198	active site
859656006199	motif 2; other site
859656006200	motif 3; other site
859656006201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
859656006202	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
859656006203	HflC protein; Region: hflC; TIGR01932
859656006204	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
859656006205	HflK protein; Region: hflK; TIGR01933
859656006206	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
859656006207	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
859656006208	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
859656006209	HflX GTPase family; Region: HflX; cd01878
859656006210	G1 box; other site
859656006211	GTP/Mg2+ binding site [chemical binding]; other site
859656006212	Switch I region; other site
859656006213	G2 box; other site
859656006214	G3 box; other site
859656006215	Switch II region; other site
859656006216	G4 box; other site
859656006217	bacterial Hfq-like; Region: Hfq; cd01716
859656006218	hexamer interface [polypeptide binding]; other site
859656006219	Sm1 motif; other site
859656006220	RNA binding site [nucleotide binding]; other site
859656006221	Sm2 motif; other site
859656006222	GTP-binding protein Der; Reviewed; Region: PRK00093
859656006223	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
859656006224	G1 box; other site
859656006225	GTP/Mg2+ binding site [chemical binding]; other site
859656006226	Switch I region; other site
859656006227	G2 box; other site
859656006228	Switch II region; other site
859656006229	G3 box; other site
859656006230	G4 box; other site
859656006231	G5 box; other site
859656006232	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
859656006233	G1 box; other site
859656006234	GTP/Mg2+ binding site [chemical binding]; other site
859656006235	Switch I region; other site
859656006236	G2 box; other site
859656006237	G3 box; other site
859656006238	Switch II region; other site
859656006239	G4 box; other site
859656006240	G5 box; other site
859656006241	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
859656006242	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
859656006243	Trp docking motif [polypeptide binding]; other site
859656006244	active site
859656006245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
859656006246	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
859656006247	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
859656006248	dimer interface [polypeptide binding]; other site
859656006249	motif 1; other site
859656006250	active site
859656006251	motif 2; other site
859656006252	motif 3; other site
859656006253	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
859656006254	anticodon binding site; other site
859656006255	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
859656006256	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
859656006257	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
859656006258	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656006259	non-specific DNA binding site [nucleotide binding]; other site
859656006260	salt bridge; other site
859656006261	sequence-specific DNA binding site [nucleotide binding]; other site
859656006262	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
859656006263	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
859656006264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656006265	binding surface
859656006266	TPR motif; other site
859656006267	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656006268	binding surface
859656006269	TPR motif; other site
859656006270	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
859656006271	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656006272	FeS/SAM binding site; other site
859656006273	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
859656006274	active site
859656006275	multimer interface [polypeptide binding]; other site
859656006276	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
859656006277	YccA-like proteins; Region: YccA_like; cd10433
859656006278	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
859656006279	TRAM domain; Region: TRAM; pfam01938
859656006280	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859656006281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656006282	S-adenosylmethionine binding site [chemical binding]; other site
859656006283	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
859656006284	putative catalytic site [active]
859656006285	putative metal binding site [ion binding]; other site
859656006286	putative phosphate binding site [ion binding]; other site
859656006287	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
859656006288	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859656006289	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656006290	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
859656006291	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656006292	DNA binding residues [nucleotide binding]
859656006293	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
859656006294	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859656006295	Peptidase family M23; Region: Peptidase_M23; pfam01551
859656006296	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
859656006297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656006298	S-adenosylmethionine binding site [chemical binding]; other site
859656006299	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
859656006300	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
859656006301	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
859656006302	NAD(P) binding site [chemical binding]; other site
859656006303	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859656006304	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
859656006305	FMN binding site [chemical binding]; other site
859656006306	active site
859656006307	substrate binding site [chemical binding]; other site
859656006308	catalytic residue [active]
859656006309	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656006310	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656006311	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859656006312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656006313	dimer interface [polypeptide binding]; other site
859656006314	conserved gate region; other site
859656006315	putative PBP binding loops; other site
859656006316	ABC-ATPase subunit interface; other site
859656006317	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859656006318	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859656006319	Walker A/P-loop; other site
859656006320	ATP binding site [chemical binding]; other site
859656006321	Q-loop/lid; other site
859656006322	ABC transporter signature motif; other site
859656006323	Walker B; other site
859656006324	D-loop; other site
859656006325	H-loop/switch region; other site
859656006326	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859656006327	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656006328	membrane-bound complex binding site; other site
859656006329	hinge residues; other site
859656006330	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859656006331	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859656006332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656006333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656006334	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
859656006335	putative dimerization interface [polypeptide binding]; other site
859656006336	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
859656006337	recombination protein RecR; Reviewed; Region: recR; PRK00076
859656006338	RecR protein; Region: RecR; pfam02132
859656006339	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
859656006340	putative active site [active]
859656006341	putative metal-binding site [ion binding]; other site
859656006342	tetramer interface [polypeptide binding]; other site
859656006343	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
859656006344	hypothetical protein; Validated; Region: PRK00153
859656006345	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
859656006346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656006347	Walker A motif; other site
859656006348	ATP binding site [chemical binding]; other site
859656006349	Walker B motif; other site
859656006350	DNA polymerase III subunit delta'; Validated; Region: PRK08485
859656006351	arginine finger; other site
859656006352	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
859656006353	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
859656006354	Family description; Region: UvrD_C_2; pfam13538
859656006355	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
859656006356	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
859656006357	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
859656006358	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859656006359	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656006360	catalytic residues [active]
859656006361	transcription termination factor Rho; Provisional; Region: rho; PRK09376
859656006362	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
859656006363	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
859656006364	RNA binding site [nucleotide binding]; other site
859656006365	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
859656006366	multimer interface [polypeptide binding]; other site
859656006367	Walker A motif; other site
859656006368	ATP binding site [chemical binding]; other site
859656006369	Walker B motif; other site
859656006370	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859656006371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656006372	Walker A motif; other site
859656006373	ATP binding site [chemical binding]; other site
859656006374	Walker B motif; other site
859656006375	arginine finger; other site
859656006376	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656006377	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656006378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656006379	active site
859656006380	phosphorylation site [posttranslational modification]
859656006381	intermolecular recognition site; other site
859656006382	dimerization interface [polypeptide binding]; other site
859656006383	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656006384	DNA binding residues [nucleotide binding]
859656006385	dimerization interface [polypeptide binding]; other site
859656006386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228
859656006387	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
859656006388	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859656006389	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
859656006390	putative efflux protein, MATE family; Region: matE; TIGR00797
859656006391	cation binding site [ion binding]; other site
859656006392	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
859656006393	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
859656006394	active site
859656006395	HIGH motif; other site
859656006396	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
859656006397	active site
859656006398	KMSKS motif; other site
859656006399	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859656006400	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
859656006401	nucleophile elbow; other site
859656006402	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
859656006403	NlpC/P60 family; Region: NLPC_P60; pfam00877
859656006404	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
859656006405	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656006406	Walker A/P-loop; other site
859656006407	ATP binding site [chemical binding]; other site
859656006408	Q-loop/lid; other site
859656006409	ABC transporter signature motif; other site
859656006410	Walker B; other site
859656006411	D-loop; other site
859656006412	H-loop/switch region; other site
859656006413	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859656006414	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656006415	Walker A/P-loop; other site
859656006416	ATP binding site [chemical binding]; other site
859656006417	Q-loop/lid; other site
859656006418	ABC transporter signature motif; other site
859656006419	Walker B; other site
859656006420	D-loop; other site
859656006421	H-loop/switch region; other site
859656006422	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
859656006423	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
859656006424	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
859656006425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656006426	dimer interface [polypeptide binding]; other site
859656006427	conserved gate region; other site
859656006428	putative PBP binding loops; other site
859656006429	ABC-ATPase subunit interface; other site
859656006430	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
859656006431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656006432	dimer interface [polypeptide binding]; other site
859656006433	conserved gate region; other site
859656006434	putative PBP binding loops; other site
859656006435	ABC-ATPase subunit interface; other site
859656006436	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
859656006437	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
859656006438	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
859656006439	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
859656006440	NAD binding site [chemical binding]; other site
859656006441	homotetramer interface [polypeptide binding]; other site
859656006442	homodimer interface [polypeptide binding]; other site
859656006443	substrate binding site [chemical binding]; other site
859656006444	active site
859656006445	aspartate kinase; Reviewed; Region: PRK06635
859656006446	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
859656006447	putative nucleotide binding site [chemical binding]; other site
859656006448	putative catalytic residues [active]
859656006449	putative Mg ion binding site [ion binding]; other site
859656006450	putative aspartate binding site [chemical binding]; other site
859656006451	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
859656006452	putative allosteric regulatory site; other site
859656006453	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
859656006454	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
859656006455	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
859656006456	Ligand Binding Site [chemical binding]; other site
859656006457	TilS substrate binding domain; Region: TilS; pfam09179
859656006458	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
859656006459	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
859656006460	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
859656006461	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859656006462	endonuclease III; Region: ENDO3c; smart00478
859656006463	minor groove reading motif; other site
859656006464	helix-hairpin-helix signature motif; other site
859656006465	substrate binding pocket [chemical binding]; other site
859656006466	active site
859656006467	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
859656006468	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
859656006469	active site
859656006470	HIGH motif; other site
859656006471	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
859656006472	KMSKS motif; other site
859656006473	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
859656006474	tRNA binding surface [nucleotide binding]; other site
859656006475	anticodon binding site; other site
859656006476	TPR repeat; Region: TPR_11; pfam13414
859656006477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656006478	binding surface
859656006479	TPR motif; other site
859656006480	TPR repeat; Region: TPR_11; pfam13414
859656006481	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
859656006482	substrate binding site [chemical binding]; other site
859656006483	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
859656006484	substrate binding site [chemical binding]; other site
859656006485	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656006486	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
859656006487	putative active site [active]
859656006488	putative metal binding site [ion binding]; other site
859656006489	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
859656006490	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
859656006491	trimer interface [polypeptide binding]; other site
859656006492	active site
859656006493	substrate binding site [chemical binding]; other site
859656006494	CoA binding site [chemical binding]; other site
859656006495	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
859656006496	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
859656006497	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
859656006498	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
859656006499	active site
859656006500	dimerization interface [polypeptide binding]; other site
859656006501	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
859656006502	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656006503	non-specific DNA binding site [nucleotide binding]; other site
859656006504	salt bridge; other site
859656006505	sequence-specific DNA binding site [nucleotide binding]; other site
859656006506	Cupin domain; Region: Cupin_2; pfam07883
859656006507	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
859656006508	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
859656006509	catalytic triad [active]
859656006510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
859656006511	MOSC domain; Region: MOSC; pfam03473
859656006512	3-alpha domain; Region: 3-alpha; pfam03475
859656006513	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
859656006514	dimer interface [polypeptide binding]; other site
859656006515	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656006516	dimerization interface [polypeptide binding]; other site
859656006517	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656006518	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656006519	dimer interface [polypeptide binding]; other site
859656006520	putative CheW interface [polypeptide binding]; other site
859656006521	Cache domain; Region: Cache_2; pfam08269
859656006522	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656006523	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656006524	dimer interface [polypeptide binding]; other site
859656006525	putative CheW interface [polypeptide binding]; other site
859656006526	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859656006527	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859656006528	active site
859656006529	catalytic tetrad [active]
859656006530	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859656006531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656006532	putative substrate translocation pore; other site
859656006533	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656006534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656006535	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656006536	dimerization interface [polypeptide binding]; other site
859656006537	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
859656006538	MutS domain I; Region: MutS_I; pfam01624
859656006539	MutS domain II; Region: MutS_II; pfam05188
859656006540	MutS domain III; Region: MutS_III; pfam05192
859656006541	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
859656006542	Walker A/P-loop; other site
859656006543	ATP binding site [chemical binding]; other site
859656006544	Q-loop/lid; other site
859656006545	ABC transporter signature motif; other site
859656006546	Walker B; other site
859656006547	D-loop; other site
859656006548	H-loop/switch region; other site
859656006549	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
859656006550	Uncharacterized conserved protein [Function unknown]; Region: COG2850
859656006551	Cupin-like domain; Region: Cupin_8; pfam13621
859656006552	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
859656006553	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
859656006554	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
859656006555	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
859656006556	dihydrodipicolinate synthase; Region: dapA; TIGR00674
859656006557	dimer interface [polypeptide binding]; other site
859656006558	active site
859656006559	catalytic residue [active]
859656006560	Methyltransferase domain; Region: Methyltransf_18; pfam12847
859656006561	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
859656006562	active site
859656006563	HIGH motif; other site
859656006564	dimer interface [polypeptide binding]; other site
859656006565	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656006566	active site
859656006567	KMSKS motif; other site
859656006568	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
859656006569	Peptidase family M50; Region: Peptidase_M50; pfam02163
859656006570	active site
859656006571	putative substrate binding region [chemical binding]; other site
859656006572	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
859656006573	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
859656006574	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
859656006575	active site
859656006576	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
859656006577	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
859656006578	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859656006579	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
859656006580	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
859656006581	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
859656006582	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859656006583	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656006584	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
859656006585	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
859656006586	dinuclear metal binding motif [ion binding]; other site
859656006587	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
859656006588	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
859656006589	trimer interface [polypeptide binding]; other site
859656006590	putative metal binding site [ion binding]; other site
859656006591	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
859656006592	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
859656006593	dimerization interface [polypeptide binding]; other site
859656006594	domain crossover interface; other site
859656006595	redox-dependent activation switch; other site
859656006596	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
859656006597	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
859656006598	enolase; Provisional; Region: eno; PRK00077
859656006599	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
859656006600	dimer interface [polypeptide binding]; other site
859656006601	metal binding site [ion binding]; metal-binding site
859656006602	substrate binding pocket [chemical binding]; other site
859656006603	Uncharacterized conserved protein [Function unknown]; Region: COG5470
859656006604	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
859656006605	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
859656006606	CTP synthetase; Validated; Region: pyrG; PRK05380
859656006607	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
859656006608	Catalytic site [active]
859656006609	active site
859656006610	UTP binding site [chemical binding]; other site
859656006611	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
859656006612	active site
859656006613	putative oxyanion hole; other site
859656006614	catalytic triad [active]
859656006615	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859656006616	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
859656006617	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
859656006618	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
859656006619	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859656006620	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
859656006621	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859656006622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
859656006623	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
859656006624	Uncharacterized conserved protein [Function unknown]; Region: COG2308
859656006625	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
859656006626	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
859656006627	Competence protein; Region: Competence; pfam03772
859656006628	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656006629	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
859656006630	active site
859656006631	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
859656006632	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859656006633	Walker A/P-loop; other site
859656006634	ATP binding site [chemical binding]; other site
859656006635	Q-loop/lid; other site
859656006636	ABC transporter signature motif; other site
859656006637	Walker B; other site
859656006638	D-loop; other site
859656006639	H-loop/switch region; other site
859656006640	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
859656006641	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
859656006642	FtsX-like permease family; Region: FtsX; pfam02687
859656006643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
859656006644	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
859656006645	DHH family; Region: DHH; pfam01368
859656006646	DHHA1 domain; Region: DHHA1; pfam02272
859656006647	Ferredoxin [Energy production and conversion]; Region: COG1146
859656006648	4Fe-4S binding domain; Region: Fer4; cl02805
859656006649	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
859656006650	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859656006651	active site
859656006652	DNA binding site [nucleotide binding]
859656006653	Int/Topo IB signature motif; other site
859656006654	CHAP domain; Region: CHAP; cl17642
859656006655	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
859656006656	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656006657	active site
859656006658	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
859656006659	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
859656006660	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656006661	catalytic residue [active]
859656006662	Phage-related protein, tail component [Function unknown]; Region: COG4733
859656006663	Putative phage tail protein; Region: Phage-tail_3; pfam13550
859656006664	Fibronectin type 3 domain; Region: FN3; smart00060
859656006665	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
859656006666	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
859656006667	HicB family; Region: HicB; pfam05534
859656006668	Phage-related protein, tail component [Function unknown]; Region: COG4723
859656006669	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
859656006670	MPN+ (JAMM) motif; other site
859656006671	Zinc-binding site [ion binding]; other site
859656006672	NlpC/P60 family; Region: NLPC_P60; cl17555
859656006673	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
859656006674	Phage minor tail protein L; Region: Phage_tail_L; cl01908
859656006675	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
859656006676	Phage Tail Collar Domain; Region: Collar; pfam07484
859656006677	Phage minor tail protein; Region: Phage_min_tail; pfam05939
859656006678	Phage-related minor tail protein [Function unknown]; Region: COG5281
859656006679	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
859656006680	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
859656006681	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
859656006682	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
859656006683	Phage tail protein; Region: Phage_tail_3; pfam08813
859656006684	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
859656006685	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
859656006686	Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614
859656006687	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
859656006688	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
859656006689	oligomerization interface [polypeptide binding]; other site
859656006690	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
859656006691	Phage capsid family; Region: Phage_capsid; pfam05065
859656006692	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
859656006693	oligomer interface [polypeptide binding]; other site
859656006694	active site residues [active]
859656006695	Phage-related protein [Function unknown]; Region: COG4695; cl01923
859656006696	Phage portal protein; Region: Phage_portal; pfam04860
859656006697	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
859656006698	Phage terminase, small subunit; Region: Terminase_4; cl01525
859656006699	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
859656006700	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
859656006701	active site
859656006702	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
859656006703	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656006704	sequence-specific DNA binding site [nucleotide binding]; other site
859656006705	salt bridge; other site
859656006706	Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338
859656006707	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
859656006708	HD domain; Region: HD_3; cl17350
859656006709	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
859656006710	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
859656006711	cofactor binding site; other site
859656006712	DNA binding site [nucleotide binding]
859656006713	substrate interaction site [chemical binding]; other site
859656006714	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
859656006715	Helix-turn-helix domain; Region: HTH_17; pfam12728
859656006716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
859656006717	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859656006718	MarR family; Region: MarR_2; pfam12802
859656006719	Predicted membrane protein [Function unknown]; Region: COG2855
859656006720	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
859656006721	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
859656006722	putative dimerization interface [polypeptide binding]; other site
859656006723	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
859656006724	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
859656006725	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
859656006726	Cytochrome P450; Region: p450; cl12078
859656006727	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656006728	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656006729	non-specific DNA binding site [nucleotide binding]; other site
859656006730	salt bridge; other site
859656006731	sequence-specific DNA binding site [nucleotide binding]; other site
859656006732	Predicted permeases [General function prediction only]; Region: COG0679
859656006733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656006734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656006735	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
859656006736	putative dimerization interface [polypeptide binding]; other site
859656006737	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
859656006738	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
859656006739	active site
859656006740	tetramer interface [polypeptide binding]; other site
859656006741	Transcriptional regulators [Transcription]; Region: FadR; COG2186
859656006742	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656006743	DNA-binding site [nucleotide binding]; DNA binding site
859656006744	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
859656006745	Predicted membrane protein [Function unknown]; Region: COG2261
859656006746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656006747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656006748	DNA binding site [nucleotide binding]
859656006749	Evidence 4 : Homologs of previously reported genes of unknown function
859656006750	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
859656006751	CHASE2 domain; Region: CHASE2; pfam05226
859656006752	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656006753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656006754	dimer interface [polypeptide binding]; other site
859656006755	phosphorylation site [posttranslational modification]
859656006756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656006757	ATP binding site [chemical binding]; other site
859656006758	G-X-G motif; other site
859656006759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
859656006760	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859656006761	FecR protein; Region: FecR; pfam04773
859656006762	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656006763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656006764	active site
859656006765	phosphorylation site [posttranslational modification]
859656006766	intermolecular recognition site; other site
859656006767	dimerization interface [polypeptide binding]; other site
859656006768	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656006769	DNA binding site [nucleotide binding]
859656006770	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
859656006771	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
859656006772	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
859656006773	GIY-YIG motif/motif A; other site
859656006774	active site
859656006775	catalytic site [active]
859656006776	putative DNA binding site [nucleotide binding]; other site
859656006777	metal binding site [ion binding]; metal-binding site
859656006778	UvrB/uvrC motif; Region: UVR; pfam02151
859656006779	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
859656006780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
859656006781	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
859656006782	elongation factor P; Validated; Region: PRK00529
859656006783	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
859656006784	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
859656006785	RNA binding site [nucleotide binding]; other site
859656006786	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
859656006787	RNA binding site [nucleotide binding]; other site
859656006788	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
859656006789	beta-hexosaminidase; Provisional; Region: PRK05337
859656006790	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
859656006791	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
859656006792	active site
859656006793	hydrophilic channel; other site
859656006794	dimerization interface [polypeptide binding]; other site
859656006795	catalytic residues [active]
859656006796	active site lid [active]
859656006797	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
859656006798	Recombination protein O N terminal; Region: RecO_N; pfam11967
859656006799	Recombination protein O C terminal; Region: RecO_C; pfam02565
859656006800	GTPase Era; Reviewed; Region: era; PRK00089
859656006801	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
859656006802	G1 box; other site
859656006803	GTP/Mg2+ binding site [chemical binding]; other site
859656006804	Switch I region; other site
859656006805	G2 box; other site
859656006806	Switch II region; other site
859656006807	G3 box; other site
859656006808	G4 box; other site
859656006809	G5 box; other site
859656006810	KH domain; Region: KH_2; pfam07650
859656006811	ribonuclease III; Reviewed; Region: rnc; PRK00102
859656006812	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
859656006813	dimerization interface [polypeptide binding]; other site
859656006814	active site
859656006815	metal binding site [ion binding]; metal-binding site
859656006816	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
859656006817	dsRNA binding site [nucleotide binding]; other site
859656006818	signal peptidase I; Provisional; Region: PRK10861
859656006819	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859656006820	Catalytic site [active]
859656006821	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
859656006822	GTP-binding protein LepA; Provisional; Region: PRK05433
859656006823	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
859656006824	G1 box; other site
859656006825	putative GEF interaction site [polypeptide binding]; other site
859656006826	GTP/Mg2+ binding site [chemical binding]; other site
859656006827	Switch I region; other site
859656006828	G2 box; other site
859656006829	G3 box; other site
859656006830	Switch II region; other site
859656006831	G4 box; other site
859656006832	G5 box; other site
859656006833	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
859656006834	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
859656006835	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
859656006836	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
859656006837	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
859656006838	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859656006839	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859656006840	protein binding site [polypeptide binding]; other site
859656006841	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859656006842	protein binding site [polypeptide binding]; other site
859656006843	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
859656006844	anti-sigma E factor; Provisional; Region: rseB; PRK09455
859656006845	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
859656006846	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
859656006847	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
859656006848	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656006849	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656006850	DNA binding residues [nucleotide binding]
859656006851	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
859656006852	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859656006853	dimer interface [polypeptide binding]; other site
859656006854	active site
859656006855	acyl carrier protein; Provisional; Region: acpP; PRK00982
859656006856	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859656006857	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
859656006858	NAD(P) binding site [chemical binding]; other site
859656006859	homotetramer interface [polypeptide binding]; other site
859656006860	homodimer interface [polypeptide binding]; other site
859656006861	active site
859656006862	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
859656006863	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859656006864	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
859656006865	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
859656006866	dimer interface [polypeptide binding]; other site
859656006867	active site
859656006868	CoA binding pocket [chemical binding]; other site
859656006869	putative phosphate acyltransferase; Provisional; Region: PRK05331
859656006870	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
859656006871	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
859656006872	Maf-like protein; Region: Maf; pfam02545
859656006873	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
859656006874	active site
859656006875	dimer interface [polypeptide binding]; other site
859656006876	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
859656006877	putative SAM binding site [chemical binding]; other site
859656006878	homodimer interface [polypeptide binding]; other site
859656006879	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
859656006880	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
859656006881	tandem repeat interface [polypeptide binding]; other site
859656006882	oligomer interface [polypeptide binding]; other site
859656006883	active site residues [active]
859656006884	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
859656006885	iron-sulfur cluster [ion binding]; other site
859656006886	[2Fe-2S] cluster binding site [ion binding]; other site
859656006887	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
859656006888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656006889	motif II; other site
859656006890	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
859656006891	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656006892	RNA binding surface [nucleotide binding]; other site
859656006893	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
859656006894	active site
859656006895	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
859656006896	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
859656006897	homodimer interface [polypeptide binding]; other site
859656006898	oligonucleotide binding site [chemical binding]; other site
859656006899	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
859656006900	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656006901	FeS/SAM binding site; other site
859656006902	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
859656006903	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
859656006904	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
859656006905	GTP binding site; other site
859656006906	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
859656006907	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
859656006908	dimer interface [polypeptide binding]; other site
859656006909	putative functional site; other site
859656006910	putative MPT binding site; other site
859656006911	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
859656006912	RmuC family; Region: RmuC; pfam02646
859656006913	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859656006914	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
859656006915	dimerization interface [polypeptide binding]; other site
859656006916	ligand binding site [chemical binding]; other site
859656006917	NADP binding site [chemical binding]; other site
859656006918	catalytic site [active]
859656006919	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
859656006920	Uncharacterized conserved protein [Function unknown]; Region: COG1556
859656006921	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
859656006922	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
859656006923	active site
859656006924	This domain is found in peptide chain release factors; Region: PCRF; smart00937
859656006925	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
859656006926	RF-1 domain; Region: RF-1; pfam00472
859656006927	short chain dehydrogenase; Provisional; Region: PRK07023
859656006928	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
859656006929	NADP binding site [chemical binding]; other site
859656006930	homodimer interface [polypeptide binding]; other site
859656006931	active site
859656006932	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
859656006933	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
859656006934	dimer interface [polypeptide binding]; other site
859656006935	putative anticodon binding site; other site
859656006936	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
859656006937	motif 1; other site
859656006938	active site
859656006939	motif 2; other site
859656006940	motif 3; other site
859656006941	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
859656006942	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
859656006943	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656006944	catalytic loop [active]
859656006945	iron binding site [ion binding]; other site
859656006946	chaperone protein HscA; Provisional; Region: hscA; PRK05183
859656006947	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
859656006948	nucleotide binding site [chemical binding]; other site
859656006949	putative NEF/HSP70 interaction site [polypeptide binding]; other site
859656006950	SBD interface [polypeptide binding]; other site
859656006951	co-chaperone HscB; Provisional; Region: hscB; PRK03578
859656006952	DnaJ domain; Region: DnaJ; pfam00226
859656006953	HSP70 interaction site [polypeptide binding]; other site
859656006954	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
859656006955	Evidence 4 : Homologs of previously reported genes of unknown function
859656006956	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
859656006957	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
859656006958	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
859656006959	trimerization site [polypeptide binding]; other site
859656006960	active site
859656006961	cysteine desulfurase; Provisional; Region: PRK14012
859656006962	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
859656006963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656006964	catalytic residue [active]
859656006965	Predicted transcriptional regulator [Transcription]; Region: COG1959
859656006966	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
859656006967	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
859656006968	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
859656006969	ligand binding site [chemical binding]; other site
859656006970	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
859656006971	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859656006972	Walker A/P-loop; other site
859656006973	ATP binding site [chemical binding]; other site
859656006974	Q-loop/lid; other site
859656006975	ABC transporter signature motif; other site
859656006976	Walker B; other site
859656006977	D-loop; other site
859656006978	H-loop/switch region; other site
859656006979	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859656006980	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656006981	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859656006982	TM-ABC transporter signature motif; other site
859656006983	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859656006984	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656006985	DNA binding site [nucleotide binding]
859656006986	domain linker motif; other site
859656006987	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859656006988	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859656006989	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
859656006990	substrate binding site [chemical binding]; other site
859656006991	dimer interface [polypeptide binding]; other site
859656006992	ATP binding site [chemical binding]; other site
859656006993	Site-specific recombinase; Region: SpecificRecomb; cl15411
859656006994	excinuclease ABC subunit B; Provisional; Region: PRK05298
859656006995	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656006996	ATP binding site [chemical binding]; other site
859656006997	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656006998	nucleotide binding region [chemical binding]; other site
859656006999	ATP-binding site [chemical binding]; other site
859656007000	Ultra-violet resistance protein B; Region: UvrB; pfam12344
859656007001	UvrB/uvrC motif; Region: UVR; pfam02151
859656007002	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
859656007003	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656007004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007005	homodimer interface [polypeptide binding]; other site
859656007006	catalytic residue [active]
859656007007	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
859656007008	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
859656007009	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656007010	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656007011	ferredoxin; Provisional; Region: PRK06991
859656007012	Putative Fe-S cluster; Region: FeS; pfam04060
859656007013	4Fe-4S binding domain; Region: Fer4; pfam00037
859656007014	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
859656007015	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859656007016	minor groove reading motif; other site
859656007017	helix-hairpin-helix signature motif; other site
859656007018	substrate binding pocket [chemical binding]; other site
859656007019	active site
859656007020	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
859656007021	putative FMN binding site [chemical binding]; other site
859656007022	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
859656007023	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
859656007024	EamA-like transporter family; Region: EamA; pfam00892
859656007025	EamA-like transporter family; Region: EamA; pfam00892
859656007026	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
859656007027	Cytochrome c553 [Energy production and conversion]; Region: COG2863
859656007028	Cytochrome c; Region: Cytochrom_C; cl11414
859656007029	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
859656007030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656007031	Walker A motif; other site
859656007032	ATP binding site [chemical binding]; other site
859656007033	Walker B motif; other site
859656007034	arginine finger; other site
859656007035	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
859656007036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
859656007037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656007038	S-adenosylmethionine binding site [chemical binding]; other site
859656007039	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
859656007040	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
859656007041	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
859656007042	putative active site [active]
859656007043	heat shock protein 90; Provisional; Region: PRK05218
859656007044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656007045	ATP binding site [chemical binding]; other site
859656007046	Mg2+ binding site [ion binding]; other site
859656007047	G-X-G motif; other site
859656007048	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859656007049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656007050	DNA-binding site [nucleotide binding]; DNA binding site
859656007051	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656007052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007053	homodimer interface [polypeptide binding]; other site
859656007054	catalytic residue [active]
859656007055	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
859656007056	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
859656007057	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656007058	EamA-like transporter family; Region: EamA; pfam00892
859656007059	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
859656007060	homotrimer interaction site [polypeptide binding]; other site
859656007061	putative active site [active]
859656007062	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
859656007063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656007064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007065	homodimer interface [polypeptide binding]; other site
859656007066	catalytic residue [active]
859656007067	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656007068	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
859656007069	putative C-terminal domain interface [polypeptide binding]; other site
859656007070	putative GSH binding site (G-site) [chemical binding]; other site
859656007071	putative dimer interface [polypeptide binding]; other site
859656007072	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
859656007073	putative N-terminal domain interface [polypeptide binding]; other site
859656007074	putative dimer interface [polypeptide binding]; other site
859656007075	putative substrate binding pocket (H-site) [chemical binding]; other site
859656007076	Evidence 4 : Homologs of previously reported genes of unknown function
859656007077	Evidence 4 : Homologs of previously reported genes of unknown function
859656007078	MASE1; Region: MASE1; pfam05231
859656007079	PAS fold; Region: PAS_3; pfam08447
859656007080	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656007081	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656007082	L-lactate permease; Region: Lactate_perm; cl00701
859656007083	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
859656007084	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
859656007085	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
859656007086	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
859656007087	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
859656007088	CAP-like domain; other site
859656007089	active site
859656007090	primary dimer interface [polypeptide binding]; other site
859656007091	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007092	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656007093	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656007094	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656007095	catalytic residue [active]
859656007096	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
859656007097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656007098	ATP binding site [chemical binding]; other site
859656007099	Mg2+ binding site [ion binding]; other site
859656007100	G-X-G motif; other site
859656007101	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
859656007102	anchoring element; other site
859656007103	dimer interface [polypeptide binding]; other site
859656007104	ATP binding site [chemical binding]; other site
859656007105	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
859656007106	active site
859656007107	metal binding site [ion binding]; metal-binding site
859656007108	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
859656007109	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
859656007110	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
859656007111	ABC transporter ATPase component; Reviewed; Region: PRK11147
859656007112	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656007113	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656007114	ABC transporter; Region: ABC_tran_2; pfam12848
859656007115	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
859656007116	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859656007117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656007118	substrate binding pocket [chemical binding]; other site
859656007119	membrane-bound complex binding site; other site
859656007120	hinge residues; other site
859656007121	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
859656007122	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859656007123	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
859656007124	putative ion selectivity filter; other site
859656007125	putative pore gating glutamate residue; other site
859656007126	putative H+/Cl- coupling transport residue; other site
859656007127	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859656007128	DEAD-like helicases superfamily; Region: DEXDc; smart00487
859656007129	ATP binding site [chemical binding]; other site
859656007130	Mg++ binding site [ion binding]; other site
859656007131	motif III; other site
859656007132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656007133	nucleotide binding region [chemical binding]; other site
859656007134	ATP-binding site [chemical binding]; other site
859656007135	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
859656007136	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859656007137	Uncharacterized conserved protein [Function unknown]; Region: COG4301
859656007138	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
859656007139	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
859656007140	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859656007141	hypothetical protein; Provisional; Region: PRK06815
859656007142	tetramer interface [polypeptide binding]; other site
859656007143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007144	catalytic residue [active]
859656007145	thymidylate synthase; Reviewed; Region: thyA; PRK01827
859656007146	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
859656007147	dimerization interface [polypeptide binding]; other site
859656007148	active site
859656007149	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
859656007150	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
859656007151	folate binding site [chemical binding]; other site
859656007152	NADP+ binding site [chemical binding]; other site
859656007153	peptidase PmbA; Provisional; Region: PRK11040
859656007154	hypothetical protein; Provisional; Region: PRK05255
859656007155	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
859656007156	MPT binding site; other site
859656007157	trimer interface [polypeptide binding]; other site
859656007158	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
859656007159	catalytic site [active]
859656007160	putative active site [active]
859656007161	putative substrate binding site [chemical binding]; other site
859656007162	dimer interface [polypeptide binding]; other site
859656007163	Peptidase family M48; Region: Peptidase_M48; cl12018
859656007164	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
859656007165	GTPase RsgA; Reviewed; Region: PRK00098
859656007166	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
859656007167	RNA binding site [nucleotide binding]; other site
859656007168	homodimer interface [polypeptide binding]; other site
859656007169	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
859656007170	GTPase/Zn-binding domain interface [polypeptide binding]; other site
859656007171	GTP/Mg2+ binding site [chemical binding]; other site
859656007172	G4 box; other site
859656007173	G5 box; other site
859656007174	G1 box; other site
859656007175	Switch I region; other site
859656007176	G2 box; other site
859656007177	G3 box; other site
859656007178	Switch II region; other site
859656007179	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
859656007180	CobD/CbiB family protein; Provisional; Region: PRK07630
859656007181	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
859656007182	putative active site [active]
859656007183	putative CoA binding site [chemical binding]; other site
859656007184	nudix motif; other site
859656007185	metal binding site [ion binding]; metal-binding site
859656007186	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
859656007187	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
859656007188	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
859656007189	RimM N-terminal domain; Region: RimM; pfam01782
859656007190	PRC-barrel domain; Region: PRC; pfam05239
859656007191	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
859656007192	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
859656007193	Evidence 4 : Homologs of previously reported genes of unknown function
859656007194	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
859656007195	Evidence 4 : Homologs of previously reported genes of unknown function
859656007196	Evidence 4 : Homologs of previously reported genes of unknown function
859656007197	Evidence 4 : Homologs of previously reported genes of unknown function
859656007198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859656007199	HTH-like domain; Region: HTH_21; pfam13276
859656007200	Integrase core domain; Region: rve; pfam00665
859656007201	Integrase core domain; Region: rve_3; pfam13683
859656007202	Transposase; Region: HTH_Tnp_1; pfam01527
859656007203	Evidence 4 : Homologs of previously reported genes of unknown function
859656007204	putative chaperone; Provisional; Region: PRK11678
859656007205	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
859656007206	nucleotide binding site [chemical binding]; other site
859656007207	putative NEF/HSP70 interaction site [polypeptide binding]; other site
859656007208	SBD interface [polypeptide binding]; other site
859656007209	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656007210	MULE transposase domain; Region: MULE; pfam10551
859656007211	Transposase; Region: HTH_Tnp_1; cl17663
859656007212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859656007213	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859656007214	HTH-like domain; Region: HTH_21; pfam13276
859656007215	Integrase core domain; Region: rve; pfam00665
859656007216	Integrase core domain; Region: rve_3; pfam13683
859656007217	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656007218	Evidence 4 : Homologs of previously reported genes of unknown function
859656007219	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
859656007220	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
859656007221	AsnC family; Region: AsnC_trans_reg; pfam01037
859656007222	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
859656007223	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656007224	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
859656007225	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
859656007226	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656007227	active site
859656007228	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
859656007229	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
859656007230	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
859656007231	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
859656007232	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
859656007233	Ligand binding site [chemical binding]; other site
859656007234	Electron transfer flavoprotein domain; Region: ETF; pfam01012
859656007235	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
859656007236	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
859656007237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656007238	dimer interface [polypeptide binding]; other site
859656007239	conserved gate region; other site
859656007240	ABC-ATPase subunit interface; other site
859656007241	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
859656007242	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
859656007243	Walker A/P-loop; other site
859656007244	ATP binding site [chemical binding]; other site
859656007245	Q-loop/lid; other site
859656007246	ABC transporter signature motif; other site
859656007247	Walker B; other site
859656007248	D-loop; other site
859656007249	H-loop/switch region; other site
859656007250	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
859656007251	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
859656007252	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
859656007253	putative active site [active]
859656007254	Zn binding site [ion binding]; other site
859656007255	Transglycosylase SLT domain; Region: SLT_2; pfam13406
859656007256	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656007257	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656007258	cysteine synthase B; Region: cysM; TIGR01138
859656007259	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
859656007260	dimer interface [polypeptide binding]; other site
859656007261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007262	catalytic residue [active]
859656007263	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
859656007264	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
859656007265	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
859656007266	NADP binding site [chemical binding]; other site
859656007267	homopentamer interface [polypeptide binding]; other site
859656007268	substrate binding site [chemical binding]; other site
859656007269	active site
859656007270	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
859656007271	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859656007272	putative ribose interaction site [chemical binding]; other site
859656007273	putative ADP binding site [chemical binding]; other site
859656007274	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
859656007275	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859656007276	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
859656007277	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
859656007278	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
859656007279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656007280	binding surface
859656007281	TPR motif; other site
859656007282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656007283	binding surface
859656007284	TPR motif; other site
859656007285	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
859656007286	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
859656007287	IHF dimer interface [polypeptide binding]; other site
859656007288	IHF - DNA interface [nucleotide binding]; other site
859656007289	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
859656007290	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
859656007291	RNA binding site [nucleotide binding]; other site
859656007292	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
859656007293	RNA binding site [nucleotide binding]; other site
859656007294	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
859656007295	RNA binding site [nucleotide binding]; other site
859656007296	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
859656007297	RNA binding site [nucleotide binding]; other site
859656007298	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
859656007299	RNA binding site [nucleotide binding]; other site
859656007300	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
859656007301	RNA binding site [nucleotide binding]; other site
859656007302	cytidylate kinase; Provisional; Region: cmk; PRK00023
859656007303	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
859656007304	CMP-binding site; other site
859656007305	The sites determining sugar specificity; other site
859656007306	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
859656007307	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
859656007308	hinge; other site
859656007309	active site
859656007310	prephenate dehydrogenase; Validated; Region: PRK08507
859656007311	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
859656007312	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656007313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007314	homodimer interface [polypeptide binding]; other site
859656007315	catalytic residue [active]
859656007316	chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807
859656007317	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
859656007318	Prephenate dehydratase; Region: PDT; pfam00800
859656007319	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
859656007320	putative L-Phe binding site [chemical binding]; other site
859656007321	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
859656007322	homodimer interface [polypeptide binding]; other site
859656007323	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
859656007324	substrate-cofactor binding pocket; other site
859656007325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007326	catalytic residue [active]
859656007327	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
859656007328	DNA gyrase subunit A; Validated; Region: PRK05560
859656007329	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
859656007330	CAP-like domain; other site
859656007331	active site
859656007332	primary dimer interface [polypeptide binding]; other site
859656007333	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007334	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007335	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007336	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007337	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007338	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
859656007339	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859656007340	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859656007341	ligand binding site [chemical binding]; other site
859656007342	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
859656007343	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
859656007344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656007345	S-adenosylmethionine binding site [chemical binding]; other site
859656007346	phosphoglycolate phosphatase; Provisional; Region: PRK13222
859656007347	Class I aldolases; Region: Aldolase_Class_I; cl17187
859656007348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656007349	motif II; other site
859656007350	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859656007351	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859656007352	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859656007353	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
859656007354	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
859656007355	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
859656007356	putative hydrophobic ligand binding site [chemical binding]; other site
859656007357	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656007358	dimerization interface [polypeptide binding]; other site
859656007359	putative DNA binding site [nucleotide binding]; other site
859656007360	putative Zn2+ binding site [ion binding]; other site
859656007361	LysR family transcriptional regulator; Provisional; Region: PRK14997
859656007362	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656007363	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656007364	putative effector binding pocket; other site
859656007365	dimerization interface [polypeptide binding]; other site
859656007366	short chain dehydrogenase; Provisional; Region: PRK12747
859656007367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656007368	NAD(P) binding site [chemical binding]; other site
859656007369	active site
859656007370	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859656007371	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
859656007372	FMN binding site [chemical binding]; other site
859656007373	active site
859656007374	substrate binding site [chemical binding]; other site
859656007375	catalytic residue [active]
859656007376	Pirin-related protein [General function prediction only]; Region: COG1741
859656007377	Pirin; Region: Pirin; pfam02678
859656007378	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
859656007379	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859656007380	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656007381	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype
859656007382	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
859656007383	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
859656007384	glutathionine S-transferase; Provisional; Region: PRK10542
859656007385	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
859656007386	C-terminal domain interface [polypeptide binding]; other site
859656007387	GSH binding site (G-site) [chemical binding]; other site
859656007388	dimer interface [polypeptide binding]; other site
859656007389	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
859656007390	dimer interface [polypeptide binding]; other site
859656007391	N-terminal domain interface [polypeptide binding]; other site
859656007392	substrate binding pocket (H-site) [chemical binding]; other site
859656007393	Predicted transcriptional regulators [Transcription]; Region: COG1733
859656007394	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859656007395	Predicted integral membrane protein [Function unknown]; Region: COG5455
859656007396	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656007397	Ligand Binding Site [chemical binding]; other site
859656007398	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859656007399	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
859656007400	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
859656007401	Moco binding site; other site
859656007402	metal coordination site [ion binding]; other site
859656007403	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
859656007404	CPxP  motif; other site
859656007405	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
859656007406	nudix motif; other site
859656007407	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
859656007408	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
859656007409	tetramer interface [polypeptide binding]; other site
859656007410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007411	catalytic residue [active]
859656007412	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
859656007413	active site 1 [active]
859656007414	dimer interface [polypeptide binding]; other site
859656007415	hexamer interface [polypeptide binding]; other site
859656007416	active site 2 [active]
859656007417	aldolase II superfamily protein; Provisional; Region: PRK07044
859656007418	intersubunit interface [polypeptide binding]; other site
859656007419	active site
859656007420	Zn2+ binding site [ion binding]; other site
859656007421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656007422	putative substrate translocation pore; other site
859656007423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656007424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656007425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656007426	dimerization interface [polypeptide binding]; other site
859656007427	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
859656007428	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
859656007429	active site residues [active]
859656007430	dimer interface [polypeptide binding]; other site
859656007431	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
859656007432	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
859656007433	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
859656007434	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859656007435	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656007436	N-terminal plug; other site
859656007437	ligand-binding site [chemical binding]; other site
859656007438	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
859656007439	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
859656007440	Evidence 4 : Homologs of previously reported genes of unknown function
859656007441	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
859656007442	Evidence 4 : Homologs of previously reported genes of unknown function
859656007443	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656007444	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
859656007445	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
859656007446	motif 1; other site
859656007447	active site
859656007448	motif 2; other site
859656007449	motif 3; other site
859656007450	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
859656007451	DHHA1 domain; Region: DHHA1; pfam02272
859656007452	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859656007453	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859656007454	Predicted membrane protein [Function unknown]; Region: COG3556
859656007455	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
859656007456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
859656007457	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
859656007458	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656007459	active site
859656007460	HIGH motif; other site
859656007461	nucleotide binding site [chemical binding]; other site
859656007462	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
859656007463	KMSKS motif; other site
859656007464	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
859656007465	Uncharacterized conserved protein [Function unknown]; Region: COG2353
859656007466	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
859656007467	Predicted membrane protein [Function unknown]; Region: COG3686
859656007468	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
859656007469	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
859656007470	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
859656007471	YaeQ protein; Region: YaeQ; pfam07152
859656007472	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
859656007473	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
859656007474	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
859656007475	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
859656007476	putative active site pocket [active]
859656007477	dimerization interface [polypeptide binding]; other site
859656007478	putative catalytic residue [active]
859656007479	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656007480	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656007481	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656007482	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
859656007483	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656007484	acyl-activating enzyme (AAE) consensus motif; other site
859656007485	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
859656007486	acyl-activating enzyme (AAE) consensus motif; other site
859656007487	putative AMP binding site [chemical binding]; other site
859656007488	putative active site [active]
859656007489	putative CoA binding site [chemical binding]; other site
859656007490	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
859656007491	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859656007492	catalytic residues [active]
859656007493	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
859656007494	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
859656007495	catalytic residues [active]
859656007496	Hemerythrin; Region: Hemerythrin; cd12107
859656007497	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
859656007498	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
859656007499	dimer interface [polypeptide binding]; other site
859656007500	active site
859656007501	heme binding site [chemical binding]; other site
859656007502	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
859656007503	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
859656007504	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
859656007505	putative ATP binding site [chemical binding]; other site
859656007506	putative substrate interface [chemical binding]; other site
859656007507	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
859656007508	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
859656007509	Cytochrome c; Region: Cytochrom_C; cl11414
859656007510	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
859656007511	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
859656007512	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
859656007513	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
859656007514	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
859656007515	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
859656007516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656007517	S-adenosylmethionine binding site [chemical binding]; other site
859656007518	Protein of unknown function DUF72; Region: DUF72; cl00777
859656007519	methionine sulfoxide reductase A; Provisional; Region: PRK14054
859656007520	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
859656007521	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
859656007522	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656007523	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656007524	putative DNA binding site [nucleotide binding]; other site
859656007525	putative Zn2+ binding site [ion binding]; other site
859656007526	AsnC family; Region: AsnC_trans_reg; pfam01037
859656007527	arylformamidase; Region: trp_arylform; TIGR03035
859656007528	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
859656007529	kynureninase; Region: kynureninase; TIGR01814
859656007530	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656007531	catalytic residue [active]
859656007532	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
859656007533	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859656007534	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859656007535	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656007536	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
859656007537	FAD binding site [chemical binding]; other site
859656007538	substrate binding pocket [chemical binding]; other site
859656007539	catalytic base [active]
859656007540	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
859656007541	Sulfate transporter family; Region: Sulfate_transp; pfam00916
859656007542	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
859656007543	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
859656007544	dimer interface [polypeptide binding]; other site
859656007545	decamer (pentamer of dimers) interface [polypeptide binding]; other site
859656007546	catalytic triad [active]
859656007547	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
859656007548	Predicted membrane protein [Function unknown]; Region: COG5393
859656007549	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
859656007550	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
859656007551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656007552	Walker A/P-loop; other site
859656007553	ATP binding site [chemical binding]; other site
859656007554	Q-loop/lid; other site
859656007555	ABC transporter signature motif; other site
859656007556	Walker B; other site
859656007557	D-loop; other site
859656007558	H-loop/switch region; other site
859656007559	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
859656007560	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
859656007561	nudix motif; other site
859656007562	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656007563	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
859656007564	active site
859656007565	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
859656007566	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
859656007567	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
859656007568	active site
859656007569	substrate binding site [chemical binding]; other site
859656007570	Mg2+ binding site [ion binding]; other site
859656007571	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
859656007572	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
859656007573	Predicted transporter component [General function prediction only]; Region: COG2391
859656007574	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
859656007575	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
859656007576	Ligand Binding Site [chemical binding]; other site
859656007577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
859656007578	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859656007579	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859656007580	ligand binding site [chemical binding]; other site
859656007581	translocation protein TolB; Provisional; Region: tolB; PRK02889
859656007582	TolB amino-terminal domain; Region: TolB_N; pfam04052
859656007583	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859656007584	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859656007585	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
859656007586	TolA protein; Region: tolA_full; TIGR02794
859656007587	TonB C terminal; Region: TonB_2; pfam13103
859656007588	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
859656007589	TolR protein; Region: tolR; TIGR02801
859656007590	TolQ protein; Region: tolQ; TIGR02796
859656007591	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859656007592	active site
859656007593	malonic semialdehyde reductase; Provisional; Region: PRK10538
859656007594	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656007595	NAD(P) binding site [chemical binding]; other site
859656007596	active site
859656007597	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
859656007598	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
859656007599	dimer interface [polypeptide binding]; other site
859656007600	active site
859656007601	glycine-pyridoxal phosphate binding site [chemical binding]; other site
859656007602	folate binding site [chemical binding]; other site
859656007603	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
859656007604	ATP cone domain; Region: ATP-cone; pfam03477
859656007605	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
859656007606	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859656007607	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
859656007608	PilX N-terminal; Region: PilX_N; pfam14341
859656007609	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
859656007610	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859656007611	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
859656007612	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859656007613	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
859656007614	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859656007615	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
859656007616	Type II transport protein GspH; Region: GspH; pfam12019
859656007617	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859656007618	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
859656007619	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
859656007620	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
859656007621	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859656007622	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
859656007623	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859656007624	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859656007625	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
859656007626	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
859656007627	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
859656007628	catalytic motif [active]
859656007629	Zn binding site [ion binding]; other site
859656007630	RibD C-terminal domain; Region: RibD_C; cl17279
859656007631	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
859656007632	Lumazine binding domain; Region: Lum_binding; pfam00677
859656007633	Lumazine binding domain; Region: Lum_binding; pfam00677
859656007634	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
859656007635	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
859656007636	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
859656007637	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
859656007638	homopentamer interface [polypeptide binding]; other site
859656007639	active site
859656007640	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
859656007641	aminotransferase; Validated; Region: PRK07337
859656007642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656007643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007644	homodimer interface [polypeptide binding]; other site
859656007645	catalytic residue [active]
859656007646	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656007647	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656007648	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656007649	catalytic residue [active]
859656007650	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
859656007651	succinic semialdehyde dehydrogenase; Region: PLN02278
859656007652	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859656007653	tetramerization interface [polypeptide binding]; other site
859656007654	NAD(P) binding site [chemical binding]; other site
859656007655	catalytic residues [active]
859656007656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318
859656007657	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
859656007658	Predicted amidohydrolase [General function prediction only]; Region: COG0388
859656007659	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
859656007660	active site
859656007661	catalytic triad [active]
859656007662	dimer interface [polypeptide binding]; other site
859656007663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656007664	S-adenosylmethionine binding site [chemical binding]; other site
859656007665	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859656007666	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
859656007667	active site
859656007668	FMN binding site [chemical binding]; other site
859656007669	substrate binding site [chemical binding]; other site
859656007670	homotetramer interface [polypeptide binding]; other site
859656007671	catalytic residue [active]
859656007672	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
859656007673	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
859656007674	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656007675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656007676	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
859656007677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656007678	S-adenosylmethionine binding site [chemical binding]; other site
859656007679	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
859656007680	active site residue [active]
859656007681	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
859656007682	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
859656007683	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
859656007684	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
859656007685	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
859656007686	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
859656007687	putative active site [active]
859656007688	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
859656007689	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
859656007690	active site
859656007691	substrate binding site [chemical binding]; other site
859656007692	metal binding site [ion binding]; metal-binding site
859656007693	Chain length determinant protein; Region: Wzz; cl15801
859656007694	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
859656007695	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
859656007696	Mg++ binding site [ion binding]; other site
859656007697	putative catalytic motif [active]
859656007698	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
859656007699	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
859656007700	Probable Catalytic site; other site
859656007701	metal-binding site
859656007702	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
859656007703	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
859656007704	Ligand binding site; other site
859656007705	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
859656007706	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
859656007707	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
859656007708	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
859656007709	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
859656007710	substrate binding site; other site
859656007711	tetramer interface; other site
859656007712	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
859656007713	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
859656007714	NADP binding site [chemical binding]; other site
859656007715	active site
859656007716	putative substrate binding site [chemical binding]; other site
859656007717	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
859656007718	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
859656007719	NAD binding site [chemical binding]; other site
859656007720	substrate binding site [chemical binding]; other site
859656007721	homodimer interface [polypeptide binding]; other site
859656007722	active site
859656007723	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
859656007724	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
859656007725	active site
859656007726	metal binding site [ion binding]; metal-binding site
859656007727	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859656007728	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859656007729	putative acyl-acceptor binding pocket; other site
859656007730	dihydroorotase; Provisional; Region: PRK07627
859656007731	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656007732	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
859656007733	active site
859656007734	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
859656007735	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
859656007736	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
859656007737	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
859656007738	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656007739	active site
859656007740	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
859656007741	hypothetical protein; Validated; Region: PRK00228
859656007742	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
859656007743	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656007744	RNA binding surface [nucleotide binding]; other site
859656007745	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
859656007746	active site
859656007747	uracil binding [chemical binding]; other site
859656007748	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
859656007749	DNA photolyase; Region: DNA_photolyase; pfam00875
859656007750	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859656007751	putative binding surface; other site
859656007752	active site
859656007753	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859656007754	putative binding surface; other site
859656007755	active site
859656007756	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
859656007757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656007758	ATP binding site [chemical binding]; other site
859656007759	Mg2+ binding site [ion binding]; other site
859656007760	G-X-G motif; other site
859656007761	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
859656007762	Response regulator receiver domain; Region: Response_reg; pfam00072
859656007763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656007764	active site
859656007765	phosphorylation site [posttranslational modification]
859656007766	intermolecular recognition site; other site
859656007767	dimerization interface [polypeptide binding]; other site
859656007768	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
859656007769	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656007770	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656007771	dimer interface [polypeptide binding]; other site
859656007772	putative CheW interface [polypeptide binding]; other site
859656007773	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
859656007774	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656007775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656007776	active site
859656007777	phosphorylation site [posttranslational modification]
859656007778	intermolecular recognition site; other site
859656007779	dimerization interface [polypeptide binding]; other site
859656007780	Response regulator receiver domain; Region: Response_reg; pfam00072
859656007781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656007782	active site
859656007783	phosphorylation site [posttranslational modification]
859656007784	intermolecular recognition site; other site
859656007785	dimerization interface [polypeptide binding]; other site
859656007786	Rubredoxin [Energy production and conversion]; Region: COG1773
859656007787	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
859656007788	iron binding site [ion binding]; other site
859656007789	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
859656007790	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656007791	inhibitor-cofactor binding pocket; inhibition site
859656007792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656007793	catalytic residue [active]
859656007794	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859656007795	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
859656007796	dimer interface [polypeptide binding]; other site
859656007797	active site
859656007798	catalytic residue [active]
859656007799	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
859656007800	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
859656007801	Repair protein; Region: Repair_PSII; pfam04536
859656007802	Predicted membrane protein [Function unknown]; Region: COG3762
859656007803	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
859656007804	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
859656007805	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
859656007806	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
859656007807	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
859656007808	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
859656007809	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656007810	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
859656007811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
859656007812	active site
859656007813	phosphorylation site [posttranslational modification]
859656007814	intermolecular recognition site; other site
859656007815	dimerization interface [polypeptide binding]; other site
859656007816	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
859656007817	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
859656007818	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
859656007819	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
859656007820	ATP binding site [chemical binding]; other site
859656007821	Walker A motif; other site
859656007822	hexamer interface [polypeptide binding]; other site
859656007823	Walker B motif; other site
859656007824	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
859656007825	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656007826	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
859656007827	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656007828	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
859656007829	TadE-like protein; Region: TadE; pfam07811
859656007830	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
859656007831	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
859656007832	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
859656007833	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
859656007834	Ligand binding site; other site
859656007835	Putative Catalytic site; other site
859656007836	DXD motif; other site
859656007837	trigger factor; Region: tig; TIGR00115
859656007838	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
859656007839	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
859656007840	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
859656007841	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
859656007842	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
859656007843	Methyltransferase domain; Region: Methyltransf_31; pfam13847
859656007844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656007845	S-adenosylmethionine binding site [chemical binding]; other site
859656007846	Predicted membrane protein [Function unknown]; Region: COG2246
859656007847	GtrA-like protein; Region: GtrA; pfam04138
859656007848	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
859656007849	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
859656007850	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
859656007851	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
859656007852	ring oligomerisation interface [polypeptide binding]; other site
859656007853	ATP/Mg binding site [chemical binding]; other site
859656007854	stacking interactions; other site
859656007855	hinge regions; other site
859656007856	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
859656007857	oligomerisation interface [polypeptide binding]; other site
859656007858	mobile loop; other site
859656007859	roof hairpin; other site
859656007860	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
859656007861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656007862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656007863	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
859656007864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656007865	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
859656007866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656007867	Helix-turn-helix domain; Region: HTH_18; pfam12833
859656007868	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
859656007869	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859656007870	NAD(P) binding site [chemical binding]; other site
859656007871	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656007872	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656007873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656007874	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859656007875	putative effector binding pocket; other site
859656007876	putative dimerization interface [polypeptide binding]; other site
859656007877	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
859656007878	catalytic triad [active]
859656007879	conserved cis-peptide bond; other site
859656007880	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
859656007881	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859656007882	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859656007883	Uncharacterized conserved protein [Function unknown]; Region: COG1359
859656007884	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656007885	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
859656007886	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
859656007887	potential catalytic triad [active]
859656007888	conserved cys residue [active]
859656007889	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859656007890	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
859656007891	putative NAD(P) binding site [chemical binding]; other site
859656007892	putative substrate binding site [chemical binding]; other site
859656007893	catalytic Zn binding site [ion binding]; other site
859656007894	structural Zn binding site [ion binding]; other site
859656007895	dimer interface [polypeptide binding]; other site
859656007896	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
859656007897	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656007898	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656007899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656007900	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
859656007901	putative effector binding pocket; other site
859656007902	putative dimerization interface [polypeptide binding]; other site
859656007903	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656007904	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656007905	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656007906	trimer interface [polypeptide binding]; other site
859656007907	eyelet of channel; other site
859656007908	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
859656007909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656007910	putative substrate translocation pore; other site
859656007911	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
859656007912	aconitate hydratase; Provisional; Region: acnA; PRK12881
859656007913	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859656007914	substrate binding site [chemical binding]; other site
859656007915	ligand binding site [chemical binding]; other site
859656007916	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
859656007917	substrate binding site [chemical binding]; other site
859656007918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656007919	DNA-binding site [nucleotide binding]; DNA binding site
859656007920	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859656007921	FCD domain; Region: FCD; pfam07729
859656007922	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
859656007923	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656007924	substrate binding pocket [chemical binding]; other site
859656007925	membrane-bound complex binding site; other site
859656007926	hinge residues; other site
859656007927	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656007928	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656007929	EamA-like transporter family; Region: EamA; pfam00892
859656007930	EamA-like transporter family; Region: EamA; pfam00892
859656007931	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656007932	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656007933	non-specific DNA binding site [nucleotide binding]; other site
859656007934	salt bridge; other site
859656007935	sequence-specific DNA binding site [nucleotide binding]; other site
859656007936	Integrase core domain; Region: rve; pfam00665
859656007937	AAA domain; Region: AAA_22; pfam13401
859656007938	TniQ; Region: TniQ; pfam06527
859656007939	Fic/DOC family; Region: Fic; cl00960
859656007940	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656007941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656007942	non-specific DNA binding site [nucleotide binding]; other site
859656007943	salt bridge; other site
859656007944	sequence-specific DNA binding site [nucleotide binding]; other site
859656007945	Restriction endonuclease; Region: Mrr_cat; pfam04471
859656007946	AAA ATPase domain; Region: AAA_16; pfam13191
859656007947	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process
859656007948	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656007949	Ligand Binding Site [chemical binding]; other site
859656007950	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
859656007951	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859656007952	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
859656007953	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
859656007954	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein
859656007955	recombination associated protein; Reviewed; Region: rdgC; PRK00321
859656007956	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656007957	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
859656007958	Inclusion body protein; Region: PixA; pfam12306
859656007959	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
859656007960	ApbE family; Region: ApbE; pfam02424
859656007961	FMN-binding domain; Region: FMN_bind; pfam04205
859656007962	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
859656007963	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15597743; Product type ph : phenotype
859656007964	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859656007965	short chain dehydrogenase; Provisional; Region: PRK06197
859656007966	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
859656007967	putative NAD(P) binding site [chemical binding]; other site
859656007968	active site
859656007969	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656007970	NAD(P) binding site [chemical binding]; other site
859656007971	active site
859656007972	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656007973	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656007974	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656007975	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
859656007976	putative C-terminal domain interface [polypeptide binding]; other site
859656007977	putative GSH binding site (G-site) [chemical binding]; other site
859656007978	putative dimer interface [polypeptide binding]; other site
859656007979	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
859656007980	dimer interface [polypeptide binding]; other site
859656007981	N-terminal domain interface [polypeptide binding]; other site
859656007982	putative substrate binding pocket (H-site) [chemical binding]; other site
859656007983	Cache domain; Region: Cache_1; pfam02743
859656007984	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656007985	dimerization interface [polypeptide binding]; other site
859656007986	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656007987	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656007988	dimer interface [polypeptide binding]; other site
859656007989	putative CheW interface [polypeptide binding]; other site
859656007990	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
859656007991	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
859656007992	substrate binding site [chemical binding]; other site
859656007993	catalytic Zn binding site [ion binding]; other site
859656007994	NAD binding site [chemical binding]; other site
859656007995	structural Zn binding site [ion binding]; other site
859656007996	dimer interface [polypeptide binding]; other site
859656007997	S-formylglutathione hydrolase; Region: PLN02442
859656007998	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
859656007999	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
859656008000	Paraquat-inducible protein A; Region: PqiA; pfam04403
859656008001	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
859656008002	Paraquat-inducible protein A; Region: PqiA; pfam04403
859656008003	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
859656008004	mce related protein; Region: MCE; pfam02470
859656008005	mce related protein; Region: MCE; pfam02470
859656008006	mce related protein; Region: MCE; pfam02470
859656008007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
859656008008	Protein of unknown function (DUF330); Region: DUF330; pfam03886
859656008009	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859656008010	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656008011	DNA-binding site [nucleotide binding]; DNA binding site
859656008012	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656008013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656008014	homodimer interface [polypeptide binding]; other site
859656008015	catalytic residue [active]
859656008016	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
859656008017	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
859656008018	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
859656008019	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
859656008020	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656008021	Zn2+ binding site [ion binding]; other site
859656008022	Mg2+ binding site [ion binding]; other site
859656008023	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656008024	MarR family; Region: MarR; pfam01047
859656008025	hypothetical protein; Provisional; Region: PRK07538
859656008026	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859656008027	amidase; Provisional; Region: PRK07056
859656008028	Amidase; Region: Amidase; cl11426
859656008029	PAS domain S-box; Region: sensory_box; TIGR00229
859656008030	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656008031	putative active site [active]
859656008032	heme pocket [chemical binding]; other site
859656008033	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
859656008034	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
859656008035	PAS fold; Region: PAS; pfam00989
859656008036	PAS domain; Region: PAS; smart00091
859656008037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
859656008038	putative active site [active]
859656008039	heme pocket [chemical binding]; other site
859656008040	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656008041	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656008042	metal binding site [ion binding]; metal-binding site
859656008043	active site
859656008044	I-site; other site
859656008045	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656008046	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
859656008047	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656008048	active site
859656008049	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
859656008050	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
859656008051	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
859656008052	putative DNA binding site [nucleotide binding]; other site
859656008053	putative homodimer interface [polypeptide binding]; other site
859656008054	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
859656008055	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
859656008056	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
859656008057	active site
859656008058	DNA binding site [nucleotide binding]
859656008059	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
859656008060	DNA binding site [nucleotide binding]
859656008061	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
859656008062	nucleotide binding site [chemical binding]; other site
859656008063	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
859656008064	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
859656008065	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
859656008066	active site
859656008067	catalytic triad [active]
859656008068	oxyanion hole [active]
859656008069	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
859656008070	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
859656008071	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
859656008072	ATP-grasp domain; Region: ATP-grasp; pfam02222
859656008073	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
859656008074	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
859656008075	ATP binding site [chemical binding]; other site
859656008076	active site
859656008077	substrate binding site [chemical binding]; other site
859656008078	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
859656008079	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
859656008080	intersubunit interface [polypeptide binding]; other site
859656008081	active site
859656008082	zinc binding site [ion binding]; other site
859656008083	Na+ binding site [ion binding]; other site
859656008084	pyruvate kinase; Provisional; Region: PRK05826
859656008085	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
859656008086	domain interfaces; other site
859656008087	active site
859656008088	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
859656008089	Phosphoglycerate kinase; Region: PGK; pfam00162
859656008090	substrate binding site [chemical binding]; other site
859656008091	hinge regions; other site
859656008092	ADP binding site [chemical binding]; other site
859656008093	catalytic site [active]
859656008094	Predicted permeases [General function prediction only]; Region: RarD; COG2962
859656008095	EamA-like transporter family; Region: EamA; pfam00892
859656008096	Predicted membrane protein [Function unknown]; Region: COG4392
859656008097	AzlC protein; Region: AzlC; pfam03591
859656008098	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
859656008099	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
859656008100	homodimer interface [polypeptide binding]; other site
859656008101	substrate-cofactor binding pocket; other site
859656008102	catalytic residue [active]
859656008103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
859656008104	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
859656008105	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
859656008106	putative active site [active]
859656008107	SnoaL-like domain; Region: SnoaL_3; pfam13474
859656008108	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
859656008109	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
859656008110	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
859656008111	Peptidase family M48; Region: Peptidase_M48; cl12018
859656008112	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
859656008113	trimer interface [polypeptide binding]; other site
859656008114	dimer interface [polypeptide binding]; other site
859656008115	putative active site [active]
859656008116	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
859656008117	O-Antigen ligase; Region: Wzy_C; pfam04932
859656008118	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
859656008119	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
859656008120	Pilin (bacterial filament); Region: Pilin; pfam00114
859656008121	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
859656008122	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
859656008123	CoA binding domain; Region: CoA_binding; smart00881
859656008124	CoA-ligase; Region: Ligase_CoA; pfam00549
859656008125	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
859656008126	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
859656008127	CoA-ligase; Region: Ligase_CoA; pfam00549
859656008128	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
859656008129	RecX family; Region: RecX; cl00936
859656008130	recombinase A; Provisional; Region: recA; PRK09354
859656008131	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
859656008132	hexamer interface [polypeptide binding]; other site
859656008133	Walker A motif; other site
859656008134	ATP binding site [chemical binding]; other site
859656008135	Walker B motif; other site
859656008136	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656008137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656008138	active site
859656008139	phosphorylation site [posttranslational modification]
859656008140	intermolecular recognition site; other site
859656008141	dimerization interface [polypeptide binding]; other site
859656008142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656008143	DNA binding site [nucleotide binding]
859656008144	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
859656008145	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656008146	HAMP domain; Region: HAMP; pfam00672
859656008147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656008148	dimer interface [polypeptide binding]; other site
859656008149	phosphorylation site [posttranslational modification]
859656008150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656008151	ATP binding site [chemical binding]; other site
859656008152	Mg2+ binding site [ion binding]; other site
859656008153	G-X-G motif; other site
859656008154	Predicted membrane protein [Function unknown]; Region: COG4327
859656008155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656008156	putative substrate translocation pore; other site
859656008157	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
859656008158	hypothetical protein; Provisional; Region: PRK07236
859656008159	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656008160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656008161	active site
859656008162	phosphorylation site [posttranslational modification]
859656008163	intermolecular recognition site; other site
859656008164	dimerization interface [polypeptide binding]; other site
859656008165	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656008166	DNA binding site [nucleotide binding]
859656008167	LysR family transcriptional regulator; Provisional; Region: PRK14997
859656008168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656008169	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656008170	putative effector binding pocket; other site
859656008171	dimerization interface [polypeptide binding]; other site
859656008172	Pirin-related protein [General function prediction only]; Region: COG1741
859656008173	Pirin; Region: Pirin; pfam02678
859656008174	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
859656008175	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
859656008176	serine/threonine protein kinase; Provisional; Region: PRK11768
859656008177	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859656008178	DEAD-like helicases superfamily; Region: DEXDc; smart00487
859656008179	ATP binding site [chemical binding]; other site
859656008180	Mg++ binding site [ion binding]; other site
859656008181	motif III; other site
859656008182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656008183	nucleotide binding region [chemical binding]; other site
859656008184	ATP-binding site [chemical binding]; other site
859656008185	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656008186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656008187	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
859656008188	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656008189	active site
859656008190	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
859656008191	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
859656008192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656008193	NAD(P) binding site [chemical binding]; other site
859656008194	active site
859656008195	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656008196	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12034706, 8107670; Product type e : enzyme
859656008197	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
859656008198	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
859656008199	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
859656008200	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
859656008201	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
859656008202	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656008203	FeS/SAM binding site; other site
859656008204	TRAM domain; Region: TRAM; pfam01938
859656008205	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
859656008206	PhoH-like protein; Region: PhoH; pfam02562
859656008207	unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963
859656008208	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
859656008209	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859656008210	Transporter associated domain; Region: CorC_HlyC; smart01091
859656008211	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
859656008212	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
859656008213	putative active site [active]
859656008214	catalytic triad [active]
859656008215	putative dimer interface [polypeptide binding]; other site
859656008216	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
859656008217	dimer interface [polypeptide binding]; other site
859656008218	motif 1; other site
859656008219	active site
859656008220	motif 2; other site
859656008221	motif 3; other site
859656008222	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
859656008223	DALR anticodon binding domain; Region: DALR_1; pfam05746
859656008224	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
859656008225	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656008226	active site
859656008227	motif I; other site
859656008228	motif II; other site
859656008229	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859656008230	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859656008231	putative acyl-acceptor binding pocket; other site
859656008232	Protein of unknown function DUF45; Region: DUF45; pfam01863
859656008233	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656008234	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
859656008235	dimer interface [polypeptide binding]; other site
859656008236	active site
859656008237	metal binding site [ion binding]; metal-binding site
859656008238	glutathione binding site [chemical binding]; other site
859656008239	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
859656008240	EamA-like transporter family; Region: EamA; pfam00892
859656008241	EamA-like transporter family; Region: EamA; pfam00892
859656008242	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
859656008243	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
859656008244	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
859656008245	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
859656008246	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
859656008247	SurA N-terminal domain; Region: SurA_N; pfam09312
859656008248	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859656008249	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
859656008250	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
859656008251	OstA-like protein; Region: OstA; cl00844
859656008252	Organic solvent tolerance protein; Region: OstA_C; pfam04453
859656008253	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
859656008254	Phosphotransferase enzyme family; Region: APH; pfam01636
859656008255	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
859656008256	Predicted membrane protein [Function unknown]; Region: COG4392
859656008257	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
859656008258	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
859656008259	Substrate binding site; other site
859656008260	metal-binding site
859656008261	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
859656008262	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
859656008263	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
859656008264	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656008265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656008266	metal binding site [ion binding]; metal-binding site
859656008267	active site
859656008268	I-site; other site
859656008269	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656008270	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
859656008271	proline aminopeptidase P II; Provisional; Region: PRK10879
859656008272	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
859656008273	active site
859656008274	hypothetical protein; Provisional; Region: PRK06996
859656008275	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859656008276	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
859656008277	hydroxyglutarate oxidase; Provisional; Region: PRK11728
859656008278	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
859656008279	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
859656008280	FMN binding site [chemical binding]; other site
859656008281	active site
859656008282	catalytic residues [active]
859656008283	substrate binding site [chemical binding]; other site
859656008284	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656008285	catalytic site [active]
859656008286	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
859656008287	DNA-binding protein Fis; Provisional; Region: PRK01905
859656008288	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
859656008289	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
859656008290	purine monophosphate binding site [chemical binding]; other site
859656008291	dimer interface [polypeptide binding]; other site
859656008292	putative catalytic residues [active]
859656008293	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
859656008294	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
859656008295	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
859656008296	active site
859656008297	putative DNA-binding cleft [nucleotide binding]; other site
859656008298	dimer interface [polypeptide binding]; other site
859656008299	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
859656008300	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
859656008301	putative active site [active]
859656008302	catalytic site [active]
859656008303	putative metal binding site [ion binding]; other site
859656008304	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
859656008305	RuvA N terminal domain; Region: RuvA_N; pfam01330
859656008306	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
859656008307	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
859656008308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656008309	Walker A motif; other site
859656008310	ATP binding site [chemical binding]; other site
859656008311	Walker B motif; other site
859656008312	arginine finger; other site
859656008313	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
859656008314	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
859656008315	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859656008316	catalytic core [active]
859656008317	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
859656008318	substrate binding site [chemical binding]; other site
859656008319	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
859656008320	putative active site [active]
859656008321	dimerization interface [polypeptide binding]; other site
859656008322	putative tRNAtyr binding site [nucleotide binding]; other site
859656008323	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
859656008324	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
859656008325	active site
859656008326	HIGH motif; other site
859656008327	dimer interface [polypeptide binding]; other site
859656008328	KMSKS motif; other site
859656008329	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
859656008330	RNA binding surface [nucleotide binding]; other site
859656008331	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
859656008332	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
859656008333	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
859656008334	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
859656008335	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
859656008336	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
859656008337	23S rRNA interface [nucleotide binding]; other site
859656008338	L3 interface [polypeptide binding]; other site
859656008339	OsmC-like protein; Region: OsmC; cl00767
859656008340	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
859656008341	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
859656008342	active site
859656008343	substrate binding pocket [chemical binding]; other site
859656008344	dimer interface [polypeptide binding]; other site
859656008345	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
859656008346	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
859656008347	MOFRL family; Region: MOFRL; pfam05161
859656008348	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656008349	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
859656008350	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
859656008351	putative active site [active]
859656008352	putative dimer interface [polypeptide binding]; other site
859656008353	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859656008354	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859656008355	Walker A/P-loop; other site
859656008356	ATP binding site [chemical binding]; other site
859656008357	Q-loop/lid; other site
859656008358	ABC transporter signature motif; other site
859656008359	Walker B; other site
859656008360	D-loop; other site
859656008361	H-loop/switch region; other site
859656008362	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656008363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656008364	dimer interface [polypeptide binding]; other site
859656008365	conserved gate region; other site
859656008366	putative PBP binding loops; other site
859656008367	ABC-ATPase subunit interface; other site
859656008368	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656008369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656008370	dimer interface [polypeptide binding]; other site
859656008371	conserved gate region; other site
859656008372	putative PBP binding loops; other site
859656008373	ABC-ATPase subunit interface; other site
859656008374	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656008375	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656008376	substrate binding pocket [chemical binding]; other site
859656008377	membrane-bound complex binding site; other site
859656008378	hinge residues; other site
859656008379	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
859656008380	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
859656008381	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
859656008382	NAD(P) binding site [chemical binding]; other site
859656008383	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656008384	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859656008385	dimerization interface [polypeptide binding]; other site
859656008386	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859656008387	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
859656008388	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
859656008389	Walker A/P-loop; other site
859656008390	ATP binding site [chemical binding]; other site
859656008391	Q-loop/lid; other site
859656008392	ABC transporter signature motif; other site
859656008393	Walker B; other site
859656008394	D-loop; other site
859656008395	H-loop/switch region; other site
859656008396	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
859656008397	enoyl-CoA hydratase; Provisional; Region: PRK06688
859656008398	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656008399	substrate binding site [chemical binding]; other site
859656008400	oxyanion hole (OAH) forming residues; other site
859656008401	trimer interface [polypeptide binding]; other site
859656008402	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
859656008403	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859656008404	dimer interface [polypeptide binding]; other site
859656008405	active site
859656008406	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
859656008407	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859656008408	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859656008409	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859656008410	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656008411	substrate binding site [chemical binding]; other site
859656008412	oxyanion hole (OAH) forming residues; other site
859656008413	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
859656008414	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
859656008415	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656008416	active site
859656008417	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
859656008418	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656008419	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656008420	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
859656008421	Coenzyme A transferase; Region: CoA_trans; smart00882
859656008422	Coenzyme A transferase; Region: CoA_trans; cl17247
859656008423	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
859656008424	putative active site [active]
859656008425	catalytic site [active]
859656008426	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
859656008427	PLD-like domain; Region: PLDc_2; pfam13091
859656008428	putative active site [active]
859656008429	catalytic site [active]
859656008430	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
859656008431	putative catalytic site [active]
859656008432	putative metal binding site [ion binding]; other site
859656008433	putative phosphate binding site [ion binding]; other site
859656008434	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
859656008435	nudix motif; other site
859656008436	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
859656008437	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
859656008438	dimer interface [polypeptide binding]; other site
859656008439	anticodon binding site; other site
859656008440	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
859656008441	homodimer interface [polypeptide binding]; other site
859656008442	motif 1; other site
859656008443	active site
859656008444	motif 2; other site
859656008445	GAD domain; Region: GAD; pfam02938
859656008446	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
859656008447	motif 3; other site
859656008448	Uncharacterized conserved protein [Function unknown]; Region: COG2928
859656008449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
859656008450	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
859656008451	Na binding site [ion binding]; other site
859656008452	putative glycosylation site [posttranslational modification]; other site
859656008453	putative glycosylation site [posttranslational modification]; other site
859656008454	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
859656008455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656008456	S-adenosylmethionine binding site [chemical binding]; other site
859656008457	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
859656008458	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
859656008459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
859656008460	SCP-2 sterol transfer family; Region: SCP2; pfam02036
859656008461	Tim44-like domain; Region: Tim44; cl09208
859656008462	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
859656008463	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
859656008464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656008465	S-adenosylmethionine binding site [chemical binding]; other site
859656008466	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
859656008467	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
859656008468	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
859656008469	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
859656008470	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
859656008471	HIT family signature motif; other site
859656008472	catalytic residue [active]
859656008473	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
859656008474	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859656008475	FAD binding domain; Region: FAD_binding_4; pfam01565
859656008476	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859656008477	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
859656008478	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
859656008479	Cysteine-rich domain; Region: CCG; pfam02754
859656008480	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
859656008481	Predicted membrane protein [Function unknown]; Region: COG1238
859656008482	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
859656008483	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
859656008484	Inward rectifier potassium channel; Region: IRK; pfam01007
859656008485	threonine dehydratase; Reviewed; Region: PRK09224
859656008486	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859656008487	tetramer interface [polypeptide binding]; other site
859656008488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656008489	catalytic residue [active]
859656008490	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
859656008491	putative Ile/Val binding site [chemical binding]; other site
859656008492	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
859656008493	putative Ile/Val binding site [chemical binding]; other site
859656008494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
859656008495	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
859656008496	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
859656008497	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
859656008498	putative active site [active]
859656008499	AMP-binding domain protein; Validated; Region: PRK08315
859656008500	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656008501	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
859656008502	acyl-activating enzyme (AAE) consensus motif; other site
859656008503	putative AMP binding site [chemical binding]; other site
859656008504	putative active site [active]
859656008505	putative CoA binding site [chemical binding]; other site
859656008506	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
859656008507	ATP-binding site [chemical binding]; other site
859656008508	Gluconate-6-phosphate binding site [chemical binding]; other site
859656008509	Shikimate kinase; Region: SKI; pfam01202
859656008510	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859656008511	Predicted transporter component [General function prediction only]; Region: COG2391
859656008512	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859656008513	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
859656008514	Ligand binding site; other site
859656008515	Putative Catalytic site; other site
859656008516	DXD motif; other site
859656008517	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859656008518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656008519	NAD(P) binding site [chemical binding]; other site
859656008520	active site
859656008521	acyl carrier protein; Provisional; Region: PRK09184
859656008522	Predicted membrane protein [Function unknown]; Region: COG4648
859656008523	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859656008524	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656008525	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656008526	acyl-activating enzyme (AAE) consensus motif; other site
859656008527	AMP binding site [chemical binding]; other site
859656008528	active site
859656008529	acyl-activating enzyme (AAE) consensus motif; other site
859656008530	CoA binding site [chemical binding]; other site
859656008531	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
859656008532	active site 2 [active]
859656008533	dimer interface [polypeptide binding]; other site
859656008534	active site 1 [active]
859656008535	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859656008536	putative acyl-acceptor binding pocket; other site
859656008537	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
859656008538	Predicted exporter [General function prediction only]; Region: COG4258
859656008539	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
859656008540	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
859656008541	NodB motif; other site
859656008542	active site
859656008543	catalytic site [active]
859656008544	metal binding site [ion binding]; metal-binding site
859656008545	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
859656008546	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859656008547	dimer interface [polypeptide binding]; other site
859656008548	active site
859656008549	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
859656008550	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
859656008551	putative active site 1 [active]
859656008552	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
859656008553	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
859656008554	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
859656008555	tetramer interface [polypeptide binding]; other site
859656008556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656008557	catalytic residue [active]
859656008558	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
859656008559	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859656008560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656008561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656008562	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
859656008563	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
859656008564	dimer interface [polypeptide binding]; other site
859656008565	ssDNA binding site [nucleotide binding]; other site
859656008566	tetramer (dimer of dimers) interface [polypeptide binding]; other site
859656008567	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
859656008568	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656008569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656008570	putative substrate translocation pore; other site
859656008571	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
859656008572	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859656008573	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859656008574	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
859656008575	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
859656008576	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
859656008577	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
859656008578	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
859656008579	PhoU domain; Region: PhoU; pfam01895
859656008580	PhoU domain; Region: PhoU; pfam01895
859656008581	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859656008582	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656008583	active site
859656008584	intracellular protease, PfpI family; Region: PfpI; TIGR01382
859656008585	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
859656008586	conserved cys residue [active]
859656008587	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
859656008588	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
859656008589	putative cation:proton antiport protein; Provisional; Region: PRK10669
859656008590	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
859656008591	TrkA-N domain; Region: TrkA_N; pfam02254
859656008592	TrkA-C domain; Region: TrkA_C; pfam02080
859656008593	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
859656008594	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
859656008595	putative active site [active]
859656008596	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
859656008597	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
859656008598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
859656008599	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
859656008600	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
859656008601	OstA-like protein; Region: OstA; pfam03968
859656008602	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
859656008603	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
859656008604	Walker A/P-loop; other site
859656008605	ATP binding site [chemical binding]; other site
859656008606	Q-loop/lid; other site
859656008607	ABC transporter signature motif; other site
859656008608	Walker B; other site
859656008609	D-loop; other site
859656008610	H-loop/switch region; other site
859656008611	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
859656008612	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
859656008613	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
859656008614	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
859656008615	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
859656008616	30S subunit binding site; other site
859656008617	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
859656008618	active site
859656008619	phosphorylation site [posttranslational modification]
859656008620	HPr kinase/phosphorylase; Provisional; Region: PRK05428
859656008621	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
859656008622	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
859656008623	Hpr binding site; other site
859656008624	active site
859656008625	homohexamer subunit interaction site [polypeptide binding]; other site
859656008626	psiF repeat; Region: PsiF_repeat; pfam07769
859656008627	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
859656008628	AAA domain; Region: AAA_18; pfam13238
859656008629	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
859656008630	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
859656008631	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
859656008632	minor groove reading motif; other site
859656008633	helix-hairpin-helix signature motif; other site
859656008634	substrate binding pocket [chemical binding]; other site
859656008635	active site
859656008636	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
859656008637	DNA binding and oxoG recognition site [nucleotide binding]
859656008638	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
859656008639	G1 box; other site
859656008640	GTP/Mg2+ binding site [chemical binding]; other site
859656008641	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
859656008642	G2 box; other site
859656008643	Switch I region; other site
859656008644	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
859656008645	G3 box; other site
859656008646	Switch II region; other site
859656008647	GTP/Mg2+ binding site [chemical binding]; other site
859656008648	G4 box; other site
859656008649	G5 box; other site
859656008650	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
859656008651	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
859656008652	DNA binding site [nucleotide binding]
859656008653	catalytic residue [active]
859656008654	H2TH interface [polypeptide binding]; other site
859656008655	putative catalytic residues [active]
859656008656	turnover-facilitating residue; other site
859656008657	intercalation triad [nucleotide binding]; other site
859656008658	8OG recognition residue [nucleotide binding]; other site
859656008659	putative reading head residues; other site
859656008660	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
859656008661	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
859656008662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656008663	binding surface
859656008664	TPR motif; other site
859656008665	Tetratricopeptide repeat; Region: TPR_16; pfam13432
859656008666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656008667	binding surface
859656008668	Tetratricopeptide repeat; Region: TPR_16; pfam13432
859656008669	TPR motif; other site
859656008670	TPR repeat; Region: TPR_11; pfam13414
859656008671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656008672	binding surface
859656008673	TPR motif; other site
859656008674	TPR repeat; Region: TPR_11; pfam13414
859656008675	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
859656008676	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
859656008677	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
859656008678	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
859656008679	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
859656008680	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
859656008681	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
859656008682	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656008683	active site
859656008684	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
859656008685	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
859656008686	5S rRNA interface [nucleotide binding]; other site
859656008687	CTC domain interface [polypeptide binding]; other site
859656008688	L16 interface [polypeptide binding]; other site
859656008689	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
859656008690	putative active site [active]
859656008691	catalytic residue [active]
859656008692	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
859656008693	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
859656008694	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
859656008695	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
859656008696	active site
859656008697	(T/H)XGH motif; other site
859656008698	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
859656008699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656008700	S-adenosylmethionine binding site [chemical binding]; other site
859656008701	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
859656008702	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
859656008703	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
859656008704	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
859656008705	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
859656008706	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
859656008707	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
859656008708	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
859656008709	P loop; other site
859656008710	GTP binding site [chemical binding]; other site
859656008711	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
859656008712	maleylacetoacetate isomerase; Region: maiA; TIGR01262
859656008713	C-terminal domain interface [polypeptide binding]; other site
859656008714	GSH binding site (G-site) [chemical binding]; other site
859656008715	putative dimer interface [polypeptide binding]; other site
859656008716	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
859656008717	dimer interface [polypeptide binding]; other site
859656008718	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
859656008719	N-terminal domain interface [polypeptide binding]; other site
859656008720	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
859656008721	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859656008722	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
859656008723	ANTAR domain; Region: ANTAR; pfam03861
859656008724	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859656008725	NMT1-like family; Region: NMT1_2; pfam13379
859656008726	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859656008727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656008728	dimer interface [polypeptide binding]; other site
859656008729	conserved gate region; other site
859656008730	putative PBP binding loops; other site
859656008731	ABC-ATPase subunit interface; other site
859656008732	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859656008733	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859656008734	Walker A/P-loop; other site
859656008735	ATP binding site [chemical binding]; other site
859656008736	Q-loop/lid; other site
859656008737	ABC transporter signature motif; other site
859656008738	Walker B; other site
859656008739	D-loop; other site
859656008740	H-loop/switch region; other site
859656008741	glycosyl transferase family protein; Provisional; Region: PRK08136
859656008742	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859656008743	Pirin-related protein [General function prediction only]; Region: COG1741
859656008744	Pirin; Region: Pirin; pfam02678
859656008745	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
859656008746	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
859656008747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656008748	PAS domain; Region: PAS_9; pfam13426
859656008749	putative active site [active]
859656008750	heme pocket [chemical binding]; other site
859656008751	PAS domain; Region: PAS_9; pfam13426
859656008752	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656008753	putative active site [active]
859656008754	heme pocket [chemical binding]; other site
859656008755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656008756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656008757	metal binding site [ion binding]; metal-binding site
859656008758	active site
859656008759	I-site; other site
859656008760	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
859656008761	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
859656008762	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656008763	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656008764	DNA binding residues [nucleotide binding]
859656008765	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859656008766	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
859656008767	Cu(I) binding site [ion binding]; other site
859656008768	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
859656008769	UbiA prenyltransferase family; Region: UbiA; pfam01040
859656008770	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
859656008771	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
859656008772	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859656008773	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
859656008774	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
859656008775	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
859656008776	Subunit III/VIIa interface [polypeptide binding]; other site
859656008777	Phospholipid binding site [chemical binding]; other site
859656008778	Subunit I/III interface [polypeptide binding]; other site
859656008779	Subunit III/VIb interface [polypeptide binding]; other site
859656008780	Subunit III/VIa interface; other site
859656008781	Subunit III/Vb interface [polypeptide binding]; other site
859656008782	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
859656008783	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
859656008784	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
859656008785	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
859656008786	Subunit I/III interface [polypeptide binding]; other site
859656008787	D-pathway; other site
859656008788	Subunit I/VIIc interface [polypeptide binding]; other site
859656008789	Subunit I/IV interface [polypeptide binding]; other site
859656008790	Subunit I/II interface [polypeptide binding]; other site
859656008791	Low-spin heme (heme a) binding site [chemical binding]; other site
859656008792	Subunit I/VIIa interface [polypeptide binding]; other site
859656008793	Subunit I/VIa interface [polypeptide binding]; other site
859656008794	Dimer interface; other site
859656008795	Putative water exit pathway; other site
859656008796	Binuclear center (heme a3/CuB) [ion binding]; other site
859656008797	K-pathway; other site
859656008798	Subunit I/Vb interface [polypeptide binding]; other site
859656008799	Putative proton exit pathway; other site
859656008800	Subunit I/VIb interface; other site
859656008801	Subunit I/VIc interface [polypeptide binding]; other site
859656008802	Electron transfer pathway; other site
859656008803	Subunit I/VIIIb interface [polypeptide binding]; other site
859656008804	Subunit I/VIIb interface [polypeptide binding]; other site
859656008805	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
859656008806	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
859656008807	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859656008808	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859656008809	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
859656008810	Integral membrane protein [Function unknown]; Region: COG5488
859656008811	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
859656008812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656008813	S-adenosylmethionine binding site [chemical binding]; other site
859656008814	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
859656008815	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656008816	active site
859656008817	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
859656008818	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
859656008819	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
859656008820	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
859656008821	preprotein translocase subunit SecB; Validated; Region: PRK05751
859656008822	SecA binding site; other site
859656008823	Preprotein binding site; other site
859656008824	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
859656008825	GSH binding site [chemical binding]; other site
859656008826	catalytic residues [active]
859656008827	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
859656008828	active site residue [active]
859656008829	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859656008830	catalytic core [active]
859656008831	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
859656008832	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
859656008833	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
859656008834	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
859656008835	protein binding site [polypeptide binding]; other site
859656008836	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
859656008837	Catalytic dyad [active]
859656008838	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
859656008839	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
859656008840	ATP binding site [chemical binding]; other site
859656008841	substrate interface [chemical binding]; other site
859656008842	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
859656008843	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
859656008844	heme binding site [chemical binding]; other site
859656008845	ferroxidase pore; other site
859656008846	ferroxidase diiron center [ion binding]; other site
859656008847	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
859656008848	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
859656008849	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
859656008850	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859656008851	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859656008852	Evidence 2b : Function of strongly homologous gene; Product type t : transporter
859656008853	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
859656008854	active pocket/dimerization site; other site
859656008855	active site
859656008856	phosphorylation site [posttranslational modification]
859656008857	glutathione synthetase; Provisional; Region: PRK05246
859656008858	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
859656008859	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
859656008860	Glutamate-cysteine ligase; Region: GshA; pfam08886
859656008861	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
859656008862	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
859656008863	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
859656008864	Nitrogen regulatory protein P-II; Region: P-II; smart00938
859656008865	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
859656008866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
859656008867	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
859656008868	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
859656008869	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
859656008870	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
859656008871	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
859656008872	Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142
859656008873	Protein of unknown function (DUF_B2219); Region: PPO1_KFDV; pfam12143
859656008874	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
859656008875	putative ADP-ribose binding site [chemical binding]; other site
859656008876	putative active site [active]
859656008877	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859656008878	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656008879	catalytic residues [active]
859656008880	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859656008881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656008882	active site
859656008883	phosphorylation site [posttranslational modification]
859656008884	intermolecular recognition site; other site
859656008885	dimerization interface [polypeptide binding]; other site
859656008886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656008887	Walker A motif; other site
859656008888	ATP binding site [chemical binding]; other site
859656008889	Walker B motif; other site
859656008890	arginine finger; other site
859656008891	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656008892	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859656008893	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656008894	dimer interface [polypeptide binding]; other site
859656008895	phosphorylation site [posttranslational modification]
859656008896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656008897	ATP binding site [chemical binding]; other site
859656008898	Mg2+ binding site [ion binding]; other site
859656008899	G-X-G motif; other site
859656008900	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
859656008901	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859656008902	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
859656008903	dimer interface [polypeptide binding]; other site
859656008904	[2Fe-2S] cluster binding site [ion binding]; other site
859656008905	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
859656008906	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
859656008907	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
859656008908	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
859656008909	hypothetical protein; Provisional; Region: PRK02047
859656008910	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859656008911	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656008912	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859656008913	dimerization interface [polypeptide binding]; other site
859656008914	substrate binding pocket [chemical binding]; other site
859656008915	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
859656008916	lipoate-protein ligase B; Provisional; Region: PRK14343
859656008917	lipoyl synthase; Provisional; Region: PRK05481
859656008918	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656008919	FeS/SAM binding site; other site
859656008920	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
859656008921	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
859656008922	ATP binding site [chemical binding]; other site
859656008923	Mg++ binding site [ion binding]; other site
859656008924	motif III; other site
859656008925	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
859656008926	nucleotide binding region [chemical binding]; other site
859656008927	ATP-binding site [chemical binding]; other site
859656008928	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
859656008929	putative RNA binding site [nucleotide binding]; other site
859656008930	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859656008931	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859656008932	Predicted secreted protein [Function unknown]; Region: COG5445
859656008933	Predicted integral membrane protein [Function unknown]; Region: COG5652
859656008934	Protein of unknown function (DUF330); Region: DUF330; cl01135
859656008935	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
859656008936	mce related protein; Region: MCE; pfam02470
859656008937	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
859656008938	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
859656008939	Walker A/P-loop; other site
859656008940	ATP binding site [chemical binding]; other site
859656008941	Q-loop/lid; other site
859656008942	ABC transporter signature motif; other site
859656008943	Walker B; other site
859656008944	D-loop; other site
859656008945	H-loop/switch region; other site
859656008946	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
859656008947	Permease; Region: Permease; pfam02405
859656008948	biotin--protein ligase; Provisional; Region: PRK06955
859656008949	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
859656008950	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
859656008951	pantothenate kinase; Reviewed; Region: PRK13328
859656008952	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
859656008953	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656008954	active site
859656008955	nucleotide binding site [chemical binding]; other site
859656008956	HIGH motif; other site
859656008957	KMSKS motif; other site
859656008958	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
859656008959	dinuclear metal binding motif [ion binding]; other site
859656008960	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
859656008961	catalytic residues [active]
859656008962	dimer interface [polypeptide binding]; other site
859656008963	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859656008964	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859656008965	active site
859656008966	nucleophile elbow; other site
859656008967	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859656008968	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656008969	substrate binding site [chemical binding]; other site
859656008970	oxyanion hole (OAH) forming residues; other site
859656008971	trimer interface [polypeptide binding]; other site
859656008972	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
859656008973	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859656008974	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859656008975	Bacterial transcriptional regulator; Region: IclR; pfam01614
859656008976	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
859656008977	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859656008978	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
859656008979	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859656008980	Bacterial transcriptional regulator; Region: IclR; pfam01614
859656008981	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
859656008982	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
859656008983	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859656008984	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
859656008985	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
859656008986	active site residue [active]
859656008987	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
859656008988	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
859656008989	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
859656008990	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
859656008991	substrate binding pocket [chemical binding]; other site
859656008992	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
859656008993	B12 binding site [chemical binding]; other site
859656008994	cobalt ligand [ion binding]; other site
859656008995	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
859656008996	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656008997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656008998	active site
859656008999	phosphorylation site [posttranslational modification]
859656009000	intermolecular recognition site; other site
859656009001	dimerization interface [polypeptide binding]; other site
859656009002	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656009003	DNA binding residues [nucleotide binding]
859656009004	dimerization interface [polypeptide binding]; other site
859656009005	Response regulator receiver domain; Region: Response_reg; pfam00072
859656009006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009007	active site
859656009008	phosphorylation site [posttranslational modification]
859656009009	intermolecular recognition site; other site
859656009010	dimerization interface [polypeptide binding]; other site
859656009011	Predicted small secreted protein [Function unknown]; Region: COG5510
859656009012	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
859656009013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656009014	Histidine kinase; Region: HisKA_3; pfam07730
859656009015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656009016	ATP binding site [chemical binding]; other site
859656009017	Mg2+ binding site [ion binding]; other site
859656009018	G-X-G motif; other site
859656009019	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
859656009020	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
859656009021	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
859656009022	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
859656009023	active site
859656009024	HIGH motif; other site
859656009025	KMSK motif region; other site
859656009026	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
859656009027	tRNA binding surface [nucleotide binding]; other site
859656009028	anticodon binding site; other site
859656009029	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
859656009030	Sporulation related domain; Region: SPOR; pfam05036
859656009031	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
859656009032	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
859656009033	catalytic residues [active]
859656009034	hinge region; other site
859656009035	alpha helical domain; other site
859656009036	short chain dehydrogenase; Provisional; Region: PRK07024
859656009037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656009038	NAD(P) binding site [chemical binding]; other site
859656009039	active site
859656009040	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
859656009041	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
859656009042	intersubunit interface [polypeptide binding]; other site
859656009043	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
859656009044	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
859656009045	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
859656009046	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
859656009047	DNA binding residues [nucleotide binding]
859656009048	putative dimer interface [polypeptide binding]; other site
859656009049	isovaleryl-CoA dehydrogenase; Region: PLN02519
859656009050	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
859656009051	substrate binding site [chemical binding]; other site
859656009052	FAD binding site [chemical binding]; other site
859656009053	catalytic base [active]
859656009054	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
859656009055	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
859656009056	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
859656009057	active site clefts [active]
859656009058	zinc binding site [ion binding]; other site
859656009059	dimer interface [polypeptide binding]; other site
859656009060	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
859656009061	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
859656009062	dimer interface [polypeptide binding]; other site
859656009063	active site
859656009064	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
859656009065	C factor cell-cell signaling protein; Provisional; Region: PRK09009
859656009066	NADP binding site [chemical binding]; other site
859656009067	homodimer interface [polypeptide binding]; other site
859656009068	active site
859656009069	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656009070	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656009071	active site
859656009072	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
859656009073	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
859656009074	putative catalytic residue [active]
859656009075	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
859656009076	active site
859656009077	catalytic residue [active]
859656009078	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
859656009079	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656009080	motif II; other site
859656009081	hypothetical protein; Provisional; Region: PRK01842
859656009082	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
859656009083	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
859656009084	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
859656009085	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859656009086	enoyl-CoA hydratase; Provisional; Region: PRK05995
859656009087	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656009088	substrate binding site [chemical binding]; other site
859656009089	oxyanion hole (OAH) forming residues; other site
859656009090	trimer interface [polypeptide binding]; other site
859656009091	biotin synthase; Region: bioB; TIGR00433
859656009092	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656009093	FeS/SAM binding site; other site
859656009094	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
859656009095	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
859656009096	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859656009097	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859656009098	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
859656009099	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
859656009100	carboxyltransferase (CT) interaction site; other site
859656009101	biotinylation site [posttranslational modification]; other site
859656009102	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
859656009103	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
859656009104	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
859656009105	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
859656009106	putative ligand binding site [chemical binding]; other site
859656009107	NAD binding site [chemical binding]; other site
859656009108	dimerization interface [polypeptide binding]; other site
859656009109	catalytic site [active]
859656009110	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
859656009111	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
859656009112	active site
859656009113	catalytic residues [active]
859656009114	metal binding site [ion binding]; metal-binding site
859656009115	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
859656009116	putative deacylase active site [active]
859656009117	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
859656009118	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656009119	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656009120	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656009121	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
859656009122	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656009123	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859656009124	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859656009125	FMN binding site [chemical binding]; other site
859656009126	substrate binding site [chemical binding]; other site
859656009127	putative catalytic residue [active]
859656009128	Uncharacterized conserved protein [Function unknown]; Region: COG5361
859656009129	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
859656009130	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
859656009131	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656009132	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656009133	sequence-specific DNA binding site [nucleotide binding]; other site
859656009134	salt bridge; other site
859656009135	Cupin domain; Region: Cupin_2; pfam07883
859656009136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656009137	Coenzyme A binding pocket [chemical binding]; other site
859656009138	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
859656009139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
859656009140	HTH-like domain; Region: HTH_21; pfam13276
859656009141	Integrase core domain; Region: rve; pfam00665
859656009142	Integrase core domain; Region: rve_3; pfam13683
859656009143	Transposase; Region: HTH_Tnp_1; pfam01527
859656009144	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859656009145	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009146	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859656009147	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009148	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009149	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859656009150	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009151	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009152	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
859656009153	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009154	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
859656009155	NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652
859656009156	active site
859656009157	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
859656009158	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
859656009159	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
859656009160	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
859656009161	B12 binding site [chemical binding]; other site
859656009162	cobalt ligand [ion binding]; other site
859656009163	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
859656009164	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
859656009165	Walker A; other site
859656009166	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678
859656009167	putative active site [active]
859656009168	putative substrate binding site [chemical binding]; other site
859656009169	putative coenzyme B12 binding site [chemical binding]; other site
859656009170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
859656009171	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656009172	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656009173	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656009174	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656009175	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859656009176	Predicted membrane protein [Function unknown]; Region: COG4292
859656009177	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
859656009178	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656009179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656009180	homodimer interface [polypeptide binding]; other site
859656009181	catalytic residue [active]
859656009182	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
859656009183	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
859656009184	putative active site [active]
859656009185	adenylation catalytic residue [active]
859656009186	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
859656009187	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
859656009188	hypothetical protein; Reviewed; Region: PRK09588
859656009189	Probable zinc-binding domain; Region: zf-trcl; pfam13451
859656009190	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
859656009191	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
859656009192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656009193	Walker A motif; other site
859656009194	ATP binding site [chemical binding]; other site
859656009195	Walker B motif; other site
859656009196	arginine finger; other site
859656009197	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859656009198	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859656009199	active site
859656009200	nucleophile elbow; other site
859656009201	Cupin domain; Region: Cupin_2; cl17218
859656009202	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
859656009203	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656009204	MULE transposase domain; Region: MULE; pfam10551
859656009205	Double zinc ribbon; Region: DZR; pfam12773
859656009206	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
859656009207	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
859656009208	glutaminase active site [active]
859656009209	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
859656009210	dimer interface [polypeptide binding]; other site
859656009211	active site
859656009212	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
859656009213	dimer interface [polypeptide binding]; other site
859656009214	active site
859656009215	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
859656009216	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
859656009217	Substrate binding site; other site
859656009218	Mg++ binding site; other site
859656009219	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
859656009220	active site
859656009221	substrate binding site [chemical binding]; other site
859656009222	CoA binding site [chemical binding]; other site
859656009223	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
859656009224	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
859656009225	Ligand Binding Site [chemical binding]; other site
859656009226	hypothetical protein; Validated; Region: PRK08238
859656009227	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
859656009228	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
859656009229	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859656009230	FAD binding domain; Region: FAD_binding_4; pfam01565
859656009231	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
859656009232	short chain dehydrogenase; Provisional; Region: PRK07102
859656009233	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
859656009234	NAD(P) binding site [chemical binding]; other site
859656009235	active site
859656009236	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
859656009237	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656009238	NAD(P) binding site [chemical binding]; other site
859656009239	active site
859656009240	hypothetical protein; Provisional; Region: PRK07233
859656009241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859656009242	hydroxyglutarate oxidase; Provisional; Region: PRK11728
859656009243	Predicted membrane protein [Function unknown]; Region: COG2246
859656009244	GtrA-like protein; Region: GtrA; pfam04138
859656009245	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656009246	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
859656009247	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
859656009248	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
859656009249	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
859656009250	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
859656009251	Walker A/P-loop; other site
859656009252	ATP binding site [chemical binding]; other site
859656009253	Q-loop/lid; other site
859656009254	ABC transporter signature motif; other site
859656009255	Walker B; other site
859656009256	D-loop; other site
859656009257	H-loop/switch region; other site
859656009258	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656009259	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656009260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656009261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656009262	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
859656009263	aldehyde dehydrogenase family 7 member; Region: PLN02315
859656009264	tetrameric interface [polypeptide binding]; other site
859656009265	NAD binding site [chemical binding]; other site
859656009266	catalytic residues [active]
859656009267	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656009268	RHS Repeat; Region: RHS_repeat; pfam05593
859656009269	RHS Repeat; Region: RHS_repeat; cl11982
859656009270	RHS Repeat; Region: RHS_repeat; pfam05593
859656009271	Evidence 4 : Homologs of previously reported genes of unknown function
859656009272	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656009273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656009274	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859656009275	dimerization interface [polypeptide binding]; other site
859656009276	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
859656009277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656009278	inhibitor-cofactor binding pocket; inhibition site
859656009279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656009280	catalytic residue [active]
859656009281	Arginase family; Region: Arginase; cd09989
859656009282	active site
859656009283	Mn binding site [ion binding]; other site
859656009284	oligomer interface [polypeptide binding]; other site
859656009285	Dihydroneopterin aldolase; Region: FolB; smart00905
859656009286	active site
859656009287	short chain dehydrogenase; Provisional; Region: PRK09134
859656009288	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656009289	NAD(P) binding site [chemical binding]; other site
859656009290	active site
859656009291	Uncharacterized conserved protein [Function unknown]; Region: COG1565
859656009292	muropeptide transporter; Reviewed; Region: ampG; PRK11902
859656009293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656009294	putative substrate translocation pore; other site
859656009295	Peptidase family M48; Region: Peptidase_M48; cl12018
859656009296	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859656009297	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
859656009298	putative FMN binding site [chemical binding]; other site
859656009299	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656009300	MarR family; Region: MarR; pfam01047
859656009301	Uncharacterized conserved protein [Function unknown]; Region: COG1434
859656009302	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
859656009303	putative active site [active]
859656009304	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
859656009305	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
859656009306	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
859656009307	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
859656009308	Predicted membrane protein [Function unknown]; Region: COG4682
859656009309	yiaA/B two helix domain; Region: YiaAB; pfam05360
859656009310	yiaA/B two helix domain; Region: YiaAB; pfam05360
859656009311	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
859656009312	putative active site [active]
859656009313	putative catalytic site [active]
859656009314	putative DNA binding site [nucleotide binding]; other site
859656009315	putative phosphate binding site [ion binding]; other site
859656009316	metal binding site A [ion binding]; metal-binding site
859656009317	putative AP binding site [nucleotide binding]; other site
859656009318	putative metal binding site B [ion binding]; other site
859656009319	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656009320	active site
859656009321	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
859656009322	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
859656009323	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
859656009324	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
859656009325	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859656009326	putative acyl-acceptor binding pocket; other site
859656009327	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859656009328	putative acyl-acceptor binding pocket; other site
859656009329	S-adenosylmethionine synthetase; Validated; Region: PRK05250
859656009330	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
859656009331	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
859656009332	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
859656009333	Uncharacterized conserved protein [Function unknown]; Region: COG4274
859656009334	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656009335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656009336	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
859656009337	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
859656009338	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
859656009339	active site
859656009340	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
859656009341	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
859656009342	HPP family; Region: HPP; pfam04982
859656009343	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
859656009344	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
859656009345	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656009346	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
859656009347	C-terminal domain interface [polypeptide binding]; other site
859656009348	GSH binding site (G-site) [chemical binding]; other site
859656009349	dimer interface [polypeptide binding]; other site
859656009350	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
859656009351	N-terminal domain interface [polypeptide binding]; other site
859656009352	dimer interface [polypeptide binding]; other site
859656009353	putative substrate binding pocket (H-site) [chemical binding]; other site
859656009354	Uncharacterized conserved protein [Function unknown]; Region: COG3391
859656009355	Predicted transcriptional regulator [Transcription]; Region: COG2944
859656009356	Helix-turn-helix; Region: HTH_3; pfam01381
859656009357	non-specific DNA binding site [nucleotide binding]; other site
859656009358	salt bridge; other site
859656009359	sequence-specific DNA binding site [nucleotide binding]; other site
859656009360	choline dehydrogenase; Validated; Region: PRK02106
859656009361	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859656009362	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859656009363	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656009364	substrate binding pocket [chemical binding]; other site
859656009365	membrane-bound complex binding site; other site
859656009366	hinge residues; other site
859656009367	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656009368	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656009369	active site
859656009370	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
859656009371	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
859656009372	Coenzyme A binding pocket [chemical binding]; other site
859656009373	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
859656009374	Phage Tail Collar Domain; Region: Collar; pfam07484
859656009375	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
859656009376	Phage Tail Collar Domain; Region: Collar; pfam07484
859656009377	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
859656009378	Phage Tail Collar Domain; Region: Collar; pfam07484
859656009379	Autotransporter beta-domain; Region: Autotransporter; pfam03797
859656009380	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859656009381	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859656009382	FMN binding site [chemical binding]; other site
859656009383	substrate binding site [chemical binding]; other site
859656009384	putative catalytic residue [active]
859656009385	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
859656009386	ThiC-associated domain; Region: ThiC-associated; pfam13667
859656009387	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
859656009388	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
859656009389	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
859656009390	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
859656009391	thiS-thiF/thiG interaction site; other site
859656009392	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
859656009393	ThiS interaction site; other site
859656009394	putative active site [active]
859656009395	tetramer interface [polypeptide binding]; other site
859656009396	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
859656009397	thiamine phosphate binding site [chemical binding]; other site
859656009398	active site
859656009399	pyrophosphate binding site [ion binding]; other site
859656009400	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
859656009401	putative dimer interface [polypeptide binding]; other site
859656009402	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656009403	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
859656009404	dimer interface [polypeptide binding]; other site
859656009405	substrate binding site [chemical binding]; other site
859656009406	ATP binding site [chemical binding]; other site
859656009407	Alkaline phosphatase homologues; Region: alkPPc; smart00098
859656009408	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
859656009409	active site
859656009410	dimer interface [polypeptide binding]; other site
859656009411	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
859656009412	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
859656009413	dimer interface [polypeptide binding]; other site
859656009414	active site
859656009415	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
859656009416	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
859656009417	homotetramer interface [polypeptide binding]; other site
859656009418	ligand binding site [chemical binding]; other site
859656009419	catalytic site [active]
859656009420	NAD binding site [chemical binding]; other site
859656009421	Membrane protein of unknown function; Region: DUF360; cl00850
859656009422	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
859656009423	FAD binding site [chemical binding]; other site
859656009424	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
859656009425	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
859656009426	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
859656009427	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656009428	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656009429	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656009430	catalytic residue [active]
859656009431	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
859656009432	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
859656009433	putative NAD(P) binding site [chemical binding]; other site
859656009434	active site
859656009435	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
859656009436	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656009437	putative C-terminal domain interface [polypeptide binding]; other site
859656009438	putative GSH binding site (G-site) [chemical binding]; other site
859656009439	putative dimer interface [polypeptide binding]; other site
859656009440	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
859656009441	putative N-terminal domain interface [polypeptide binding]; other site
859656009442	putative dimer interface [polypeptide binding]; other site
859656009443	putative substrate binding pocket (H-site) [chemical binding]; other site
859656009444	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
859656009445	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
859656009446	active site
859656009447	NTP binding site [chemical binding]; other site
859656009448	metal binding triad [ion binding]; metal-binding site
859656009449	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
859656009450	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656009451	Zn2+ binding site [ion binding]; other site
859656009452	Mg2+ binding site [ion binding]; other site
859656009453	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656009454	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656009455	substrate binding pocket [chemical binding]; other site
859656009456	membrane-bound complex binding site; other site
859656009457	hinge residues; other site
859656009458	Uncharacterized conserved protein [Function unknown]; Region: COG3246
859656009459	hypothetical protein; Provisional; Region: PRK07483
859656009460	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656009461	inhibitor-cofactor binding pocket; inhibition site
859656009462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656009463	catalytic residue [active]
859656009464	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859656009465	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859656009466	putative active site [active]
859656009467	Response regulator receiver domain; Region: Response_reg; pfam00072
859656009468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009469	active site
859656009470	phosphorylation site [posttranslational modification]
859656009471	intermolecular recognition site; other site
859656009472	dimerization interface [polypeptide binding]; other site
859656009473	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
859656009474	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
859656009475	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656009476	dimerization interface [polypeptide binding]; other site
859656009477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656009478	dimer interface [polypeptide binding]; other site
859656009479	phosphorylation site [posttranslational modification]
859656009480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656009481	ATP binding site [chemical binding]; other site
859656009482	Mg2+ binding site [ion binding]; other site
859656009483	G-X-G motif; other site
859656009484	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
859656009485	16S rRNA methyltransferase B; Provisional; Region: PRK10901
859656009486	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
859656009487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656009488	S-adenosylmethionine binding site [chemical binding]; other site
859656009489	M48 family peptidase; Provisional; Region: PRK03001
859656009490	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859656009491	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
859656009492	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
859656009493	putative active site [active]
859656009494	substrate binding site [chemical binding]; other site
859656009495	putative cosubstrate binding site; other site
859656009496	catalytic site [active]
859656009497	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
859656009498	substrate binding site [chemical binding]; other site
859656009499	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859656009500	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859656009501	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
859656009502	active site
859656009503	catalytic residues [active]
859656009504	metal binding site [ion binding]; metal-binding site
859656009505	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859656009506	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
859656009507	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
859656009508	DNA protecting protein DprA; Region: dprA; TIGR00732
859656009509	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
859656009510	catalytic residues [active]
859656009511	DNA topoisomerase III; Validated; Region: PRK08173
859656009512	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
859656009513	active site
859656009514	putative interdomain interaction site [polypeptide binding]; other site
859656009515	putative metal-binding site [ion binding]; other site
859656009516	putative nucleotide binding site [chemical binding]; other site
859656009517	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
859656009518	domain I; other site
859656009519	DNA binding groove [nucleotide binding]
859656009520	phosphate binding site [ion binding]; other site
859656009521	domain II; other site
859656009522	domain III; other site
859656009523	nucleotide binding site [chemical binding]; other site
859656009524	catalytic site [active]
859656009525	domain IV; other site
859656009526	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
859656009527	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
859656009528	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656009529	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656009530	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656009531	putative effector binding pocket; other site
859656009532	dimerization interface [polypeptide binding]; other site
859656009533	acyl-CoA synthetase; Validated; Region: PRK06178
859656009534	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656009535	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656009536	acyl-activating enzyme (AAE) consensus motif; other site
859656009537	acyl-activating enzyme (AAE) consensus motif; other site
859656009538	AMP binding site [chemical binding]; other site
859656009539	active site
859656009540	CoA binding site [chemical binding]; other site
859656009541	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
859656009542	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
859656009543	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
859656009544	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
859656009545	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
859656009546	rod shape-determining protein MreC; Provisional; Region: PRK13922
859656009547	rod shape-determining protein MreC; Region: MreC; pfam04085
859656009548	rod shape-determining protein MreB; Provisional; Region: PRK13927
859656009549	MreB and similar proteins; Region: MreB_like; cd10225
859656009550	nucleotide binding site [chemical binding]; other site
859656009551	Mg binding site [ion binding]; other site
859656009552	putative protofilament interaction site [polypeptide binding]; other site
859656009553	RodZ interaction site [polypeptide binding]; other site
859656009554	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
859656009555	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
859656009556	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
859656009557	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
859656009558	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
859656009559	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
859656009560	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
859656009561	GatB domain; Region: GatB_Yqey; smart00845
859656009562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3159
859656009563	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
859656009564	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
859656009565	active site
859656009566	Int/Topo IB signature motif; other site
859656009567	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
859656009568	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
859656009569	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
859656009570	putative RNA binding site [nucleotide binding]; other site
859656009571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656009572	S-adenosylmethionine binding site [chemical binding]; other site
859656009573	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
859656009574	FAD binding domain; Region: FAD_binding_4; pfam01565
859656009575	Berberine and berberine like; Region: BBE; pfam08031
859656009576	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
859656009577	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
859656009578	metal binding site 2 [ion binding]; metal-binding site
859656009579	putative DNA binding helix; other site
859656009580	metal binding site 1 [ion binding]; metal-binding site
859656009581	dimer interface [polypeptide binding]; other site
859656009582	structural Zn2+ binding site [ion binding]; other site
859656009583	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
859656009584	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
859656009585	P-loop, Walker A motif; other site
859656009586	Base recognition motif; other site
859656009587	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
859656009588	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
859656009589	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
859656009590	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
859656009591	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
859656009592	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859656009593	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
859656009594	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
859656009595	active site
859656009596	HslU subunit interaction site [polypeptide binding]; other site
859656009597	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
859656009598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656009599	Walker A motif; other site
859656009600	ATP binding site [chemical binding]; other site
859656009601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
859656009602	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
859656009603	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
859656009604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009605	active site
859656009606	phosphorylation site [posttranslational modification]
859656009607	intermolecular recognition site; other site
859656009608	dimerization interface [polypeptide binding]; other site
859656009609	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656009610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656009611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656009612	ATP binding site [chemical binding]; other site
859656009613	Mg2+ binding site [ion binding]; other site
859656009614	G-X-G motif; other site
859656009615	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
859656009616	Evidence 4 : Homologs of previously reported genes of unknown function
859656009617	Putative zinc-finger; Region: zf-HC2; pfam13490
859656009618	RNA polymerase sigma factor; Provisional; Region: PRK12520
859656009619	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656009620	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656009621	DNA binding residues [nucleotide binding]
859656009622	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
859656009623	feedback inhibition sensing region; other site
859656009624	homohexameric interface [polypeptide binding]; other site
859656009625	nucleotide binding site [chemical binding]; other site
859656009626	N-acetyl-L-glutamate binding site [chemical binding]; other site
859656009627	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
859656009628	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
859656009629	division inhibitor protein; Provisional; Region: slmA; PRK09480
859656009630	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656009631	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859656009632	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656009633	DNA-binding site [nucleotide binding]; DNA binding site
859656009634	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656009635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656009636	homodimer interface [polypeptide binding]; other site
859656009637	catalytic residue [active]
859656009638	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
859656009639	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656009640	inhibitor-cofactor binding pocket; inhibition site
859656009641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656009642	catalytic residue [active]
859656009643	succinic semialdehyde dehydrogenase; Region: PLN02278
859656009644	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859656009645	tetramerization interface [polypeptide binding]; other site
859656009646	NAD(P) binding site [chemical binding]; other site
859656009647	catalytic residues [active]
859656009648	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
859656009649	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
859656009650	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859656009651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656009652	S-adenosylmethionine binding site [chemical binding]; other site
859656009653	phasin family protein; Region: phasin; TIGR01841
859656009654	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
859656009655	Sel1 repeat; Region: Sel1; cl02723
859656009656	Sel1-like repeats; Region: SEL1; smart00671
859656009657	Sel1-like repeats; Region: SEL1; smart00671
859656009658	Protein of unknown function (DUF466); Region: DUF466; pfam04328
859656009659	carbon starvation protein A; Provisional; Region: PRK15015
859656009660	Carbon starvation protein CstA; Region: CstA; pfam02554
859656009661	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
859656009662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
859656009663	Cache domain; Region: Cache_2; pfam08269
859656009664	Histidine kinase; Region: HisKA_3; pfam07730
859656009665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656009666	ATP binding site [chemical binding]; other site
859656009667	Mg2+ binding site [ion binding]; other site
859656009668	G-X-G motif; other site
859656009669	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656009670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009671	active site
859656009672	phosphorylation site [posttranslational modification]
859656009673	intermolecular recognition site; other site
859656009674	dimerization interface [polypeptide binding]; other site
859656009675	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656009676	DNA binding residues [nucleotide binding]
859656009677	dimerization interface [polypeptide binding]; other site
859656009678	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
859656009679	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
859656009680	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
859656009681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009682	active site
859656009683	phosphorylation site [posttranslational modification]
859656009684	intermolecular recognition site; other site
859656009685	dimerization interface [polypeptide binding]; other site
859656009686	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656009687	DNA binding site [nucleotide binding]
859656009688	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
859656009689	active site
859656009690	substrate-binding site [chemical binding]; other site
859656009691	metal-binding site [ion binding]
859656009692	GTP binding site [chemical binding]; other site
859656009693	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
859656009694	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
859656009695	dimerization interface [polypeptide binding]; other site
859656009696	NAD binding site [chemical binding]; other site
859656009697	ligand binding site [chemical binding]; other site
859656009698	catalytic site [active]
859656009699	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
859656009700	putative active site [active]
859656009701	metal binding site [ion binding]; metal-binding site
859656009702	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
859656009703	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
859656009704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656009705	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859656009706	Patatin-like phospholipase; Region: Patatin; pfam01734
859656009707	active site
859656009708	nucleophile elbow; other site
859656009709	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
859656009710	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656009711	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
859656009712	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656009713	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656009714	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656009715	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
859656009716	Protein export membrane protein; Region: SecD_SecF; cl14618
859656009717	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
859656009718	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
859656009719	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
859656009720	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656009721	putative active site [active]
859656009722	putative metal binding site [ion binding]; other site
859656009723	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
859656009724	active site
859656009725	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
859656009726	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
859656009727	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
859656009728	trmE is a tRNA modification GTPase; Region: trmE; cd04164
859656009729	G1 box; other site
859656009730	GTP/Mg2+ binding site [chemical binding]; other site
859656009731	Switch I region; other site
859656009732	G2 box; other site
859656009733	Switch II region; other site
859656009734	G3 box; other site
859656009735	G4 box; other site
859656009736	G5 box; other site
859656009737	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
859656009738	membrane protein insertase; Provisional; Region: PRK01318
859656009739	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
859656009740	hypothetical protein; Validated; Region: PRK00041
859656009741	Ribonuclease P; Region: Ribonuclease_P; cl00457
859656009742	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
859656009743	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
859656009744	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859656009745	DNA-binding site [nucleotide binding]; DNA binding site
859656009746	RNA-binding motif; other site
859656009747	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
859656009748	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
859656009749	P-loop; other site
859656009750	Magnesium ion binding site [ion binding]; other site
859656009751	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859656009752	ParB-like nuclease domain; Region: ParBc; pfam02195
859656009753	Transposase protein; Region: Tnp_P_element; pfam12017
859656009754	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
859656009755	active site
859656009756	tetramer interface; other site
859656009757	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
859656009758	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656009759	putative substrate translocation pore; other site
859656009760	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
859656009761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656009762	dimer interface [polypeptide binding]; other site
859656009763	phosphorylation site [posttranslational modification]
859656009764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656009765	ATP binding site [chemical binding]; other site
859656009766	Mg2+ binding site [ion binding]; other site
859656009767	G-X-G motif; other site
859656009768	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859656009769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009770	active site
859656009771	phosphorylation site [posttranslational modification]
859656009772	intermolecular recognition site; other site
859656009773	dimerization interface [polypeptide binding]; other site
859656009774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656009775	Walker A motif; other site
859656009776	ATP binding site [chemical binding]; other site
859656009777	Walker B motif; other site
859656009778	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656009779	Predicted membrane protein [Function unknown]; Region: COG4377
859656009780	Cache domain; Region: Cache_1; pfam02743
859656009781	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
859656009782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656009783	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859656009784	putative active site [active]
859656009785	heme pocket [chemical binding]; other site
859656009786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656009787	putative active site [active]
859656009788	heme pocket [chemical binding]; other site
859656009789	PAS fold; Region: PAS_4; pfam08448
859656009790	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656009791	putative active site [active]
859656009792	heme pocket [chemical binding]; other site
859656009793	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656009794	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656009795	metal binding site [ion binding]; metal-binding site
859656009796	active site
859656009797	I-site; other site
859656009798	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656009799	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
859656009800	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656009801	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656009802	TM-ABC transporter signature motif; other site
859656009803	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656009804	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656009805	TM-ABC transporter signature motif; other site
859656009806	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859656009807	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656009808	Walker A/P-loop; other site
859656009809	ATP binding site [chemical binding]; other site
859656009810	Q-loop/lid; other site
859656009811	ABC transporter signature motif; other site
859656009812	Walker B; other site
859656009813	D-loop; other site
859656009814	H-loop/switch region; other site
859656009815	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859656009816	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656009817	Walker A/P-loop; other site
859656009818	ATP binding site [chemical binding]; other site
859656009819	Q-loop/lid; other site
859656009820	ABC transporter signature motif; other site
859656009821	Walker B; other site
859656009822	D-loop; other site
859656009823	H-loop/switch region; other site
859656009824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656009825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656009826	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656009827	dimerization interface [polypeptide binding]; other site
859656009828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
859656009829	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859656009830	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
859656009831	Cl- selectivity filter; other site
859656009832	Cl- binding residues [ion binding]; other site
859656009833	pore gating glutamate residue; other site
859656009834	dimer interface [polypeptide binding]; other site
859656009835	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859656009836	Spherulation-specific family 4; Region: Spherulin4; pfam12138
859656009837	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
859656009838	substrate binding site [chemical binding]; other site
859656009839	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
859656009840	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
859656009841	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
859656009842	F-box domain; Region: F-box; pfam00646
859656009843	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656009844	Leucine-rich repeats; other site
859656009845	Substrate binding site [chemical binding]; other site
859656009846	chemotaxis regulator CheZ; Provisional; Region: PRK11166
859656009847	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
859656009848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656009849	active site
859656009850	phosphorylation site [posttranslational modification]
859656009851	intermolecular recognition site; other site
859656009852	dimerization interface [polypeptide binding]; other site
859656009853	H-NS histone family; Region: Histone_HNS; pfam00816
859656009854	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859656009855	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
859656009856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656009857	Coenzyme A binding pocket [chemical binding]; other site
859656009858	Evidence 4 : Homologs of previously reported genes of unknown function
859656009859	Evidence 4 : Homologs of previously reported genes of unknown function
859656009860	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
859656009861	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
859656009862	Uncharacterized conserved protein [Function unknown]; Region: COG4309
859656009863	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
859656009864	Multicopper oxidase; Region: Cu-oxidase; pfam00394
859656009865	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859656009866	Cytochrome c; Region: Cytochrom_C; pfam00034
859656009867	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859656009868	Uncharacterized conserved protein [Function unknown]; Region: COG1262
859656009869	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
859656009870	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
859656009871	Cu(I) binding site [ion binding]; other site
859656009872	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
859656009873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
859656009874	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
859656009875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656009876	5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331
859656009877	Walker A motif; other site
859656009878	ATP binding site [chemical binding]; other site
859656009879	Walker B motif; other site
859656009880	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
859656009881	hypothetical protein; Provisional; Region: PRK07236
859656009882	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
859656009883	active site
859656009884	FMN binding site [chemical binding]; other site
859656009885	substrate binding site [chemical binding]; other site
859656009886	homotetramer interface [polypeptide binding]; other site
859656009887	catalytic residue [active]
859656009888	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
859656009889	classical (c) SDRs; Region: SDR_c; cd05233
859656009890	NAD(P) binding site [chemical binding]; other site
859656009891	active site
859656009892	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656009893	MarR family; Region: MarR; pfam01047
859656009894	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859656009895	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656009896	substrate binding site [chemical binding]; other site
859656009897	oxyanion hole (OAH) forming residues; other site
859656009898	trimer interface [polypeptide binding]; other site
859656009899	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656009900	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656009901	active site
859656009902	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656009903	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859656009904	acyl-activating enzyme (AAE) consensus motif; other site
859656009905	AMP binding site [chemical binding]; other site
859656009906	active site
859656009907	CoA binding site [chemical binding]; other site
859656009908	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859656009909	active site
859656009910	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859656009911	homotrimer interaction site [polypeptide binding]; other site
859656009912	putative active site [active]
859656009913	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
859656009914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656009915	putative substrate translocation pore; other site
859656009916	Predicted transcriptional regulator [Transcription]; Region: COG3636
859656009917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657
859656009918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656009919	putative substrate translocation pore; other site
859656009920	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
859656009921	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859656009922	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656009923	DNA-binding site [nucleotide binding]; DNA binding site
859656009924	UTRA domain; Region: UTRA; pfam07702
859656009925	Predicted transcriptional regulators [Transcription]; Region: COG1733
859656009926	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859656009927	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
859656009928	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656009929	putative metal binding site [ion binding]; other site
859656009930	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656009931	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656009932	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
859656009933	putative dimerization interface [polypeptide binding]; other site
859656009934	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
859656009935	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656009936	N-terminal plug; other site
859656009937	ligand-binding site [chemical binding]; other site
859656009938	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
859656009939	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
859656009940	G1 box; other site
859656009941	GTP/Mg2+ binding site [chemical binding]; other site
859656009942	G2 box; other site
859656009943	Switch I region; other site
859656009944	G3 box; other site
859656009945	Switch II region; other site
859656009946	G4 box; other site
859656009947	G5 box; other site
859656009948	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
859656009949	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656009950	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656009951	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656009952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859656009953	Uncharacterized conserved protein [Function unknown]; Region: COG4104
859656009954	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
859656009955	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
859656009956	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656009957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656009958	putative substrate translocation pore; other site
859656009959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656009960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656009961	MoxR-like ATPases [General function prediction only]; Region: COG0714
859656009962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656009963	ATP binding site [chemical binding]; other site
859656009964	Walker A motif; other site
859656009965	Walker B motif; other site
859656009966	arginine finger; other site
859656009967	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
859656009968	Protein of unknown function DUF58; Region: DUF58; pfam01882
859656009969	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
859656009970	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859656009971	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859656009972	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
859656009973	active site clefts [active]
859656009974	zinc binding site [ion binding]; other site
859656009975	dimer interface [polypeptide binding]; other site
859656009976	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
859656009977	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
859656009978	Sulfate transporter family; Region: Sulfate_transp; pfam00916
859656009979	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
859656009980	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859656009981	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859656009982	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
859656009983	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
859656009984	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
859656009985	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859656009986	substrate binding site [chemical binding]; other site
859656009987	ligand binding site [chemical binding]; other site
859656009988	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
859656009989	substrate binding site [chemical binding]; other site
859656009990	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
859656009991	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
859656009992	dimer interface [polypeptide binding]; other site
859656009993	active site
859656009994	citrylCoA binding site [chemical binding]; other site
859656009995	oxalacetate/citrate binding site [chemical binding]; other site
859656009996	coenzyme A binding site [chemical binding]; other site
859656009997	catalytic triad [active]
859656009998	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
859656009999	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
859656010000	tetramer interface [polypeptide binding]; other site
859656010001	active site
859656010002	Mg2+/Mn2+ binding site [ion binding]; other site
859656010003	Propionate catabolism activator; Region: PrpR_N; pfam06506
859656010004	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
859656010005	PAS domain; Region: PAS; smart00091
859656010006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656010007	Walker A motif; other site
859656010008	ATP binding site [chemical binding]; other site
859656010009	Walker B motif; other site
859656010010	arginine finger; other site
859656010011	Predicted transcriptional regulator [Transcription]; Region: COG2944
859656010012	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
859656010013	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
859656010014	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
859656010015	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
859656010016	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656010017	active site
859656010018	metal binding site [ion binding]; metal-binding site
859656010019	Nuclease-related domain; Region: NERD; pfam08378
859656010020	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
859656010021	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
859656010022	ATP binding site [chemical binding]; other site
859656010023	putative Mg++ binding site [ion binding]; other site
859656010024	Family description; Region: UvrD_C_2; pfam13538
859656010025	AAA domain; Region: AAA_13; pfam13166
859656010026	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656010027	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010028	RHS Repeat; Region: RHS_repeat; pfam05593
859656010029	RHS Repeat; Region: RHS_repeat; pfam05593
859656010030	RHS Repeat; Region: RHS_repeat; pfam05593
859656010031	RHS Repeat; Region: RHS_repeat; pfam05593
859656010032	RHS Repeat; Region: RHS_repeat; pfam05593
859656010033	Evidence 4 : Homologs of previously reported genes of unknown function
859656010034	Evidence 4 : Homologs of previously reported genes of unknown function
859656010035	Helix-turn-helix domain; Region: HTH_38; pfam13936
859656010036	Integrase core domain; Region: rve_3; pfam13683
859656010037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010039	metal binding site [ion binding]; metal-binding site
859656010040	active site
859656010041	I-site; other site
859656010042	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656010043	Predicted membrane protein [Function unknown]; Region: COG1289
859656010044	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
859656010045	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
859656010046	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859656010047	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
859656010048	putative active site [active]
859656010049	putative FMN binding site [chemical binding]; other site
859656010050	putative substrate binding site [chemical binding]; other site
859656010051	putative catalytic residue [active]
859656010052	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
859656010053	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
859656010054	DNA binding residues [nucleotide binding]
859656010055	acyl-CoA thioesterase; Provisional; Region: PRK10531
859656010056	putative pectinesterase; Region: PLN02432; cl01911
859656010057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656010058	Coenzyme A binding pocket [chemical binding]; other site
859656010059	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
859656010060	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656010061	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
859656010062	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656010063	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
859656010064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656010065	binding surface
859656010066	TPR motif; other site
859656010067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
859656010068	binding surface
859656010069	TPR motif; other site
859656010070	Secretin and TonB N terminus short domain; Region: STN; smart00965
859656010071	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656010072	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656010073	Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546
859656010074	dockerin binding interface; other site
859656010075	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
859656010076	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859656010077	Walker A motif; other site
859656010078	ATP binding site [chemical binding]; other site
859656010079	Walker B motif; other site
859656010080	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
859656010081	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656010082	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656010083	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
859656010084	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656010085	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
859656010086	putative active site [active]
859656010087	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010088	RHS Repeat; Region: RHS_repeat; pfam05593
859656010089	RHS Repeat; Region: RHS_repeat; pfam05593
859656010090	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859656010091	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010092	RHS Repeat; Region: RHS_repeat; pfam05593
859656010093	RHS Repeat; Region: RHS_repeat; pfam05593
859656010094	RHS Repeat; Region: RHS_repeat; pfam05593
859656010095	RHS Repeat; Region: RHS_repeat; pfam05593
859656010096	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010097	RHS Repeat; Region: RHS_repeat; cl11982
859656010098	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010099	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010100	putative transposase OrfB; Reviewed; Region: PHA02517
859656010101	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
859656010102	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
859656010103	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
859656010104	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
859656010105	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
859656010106	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
859656010107	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
859656010108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
859656010109	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859656010110	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
859656010111	acyl-activating enzyme (AAE) consensus motif; other site
859656010112	AMP binding site [chemical binding]; other site
859656010113	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656010114	Condensation domain; Region: Condensation; pfam00668
859656010115	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656010116	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
859656010117	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859656010118	acyl-activating enzyme (AAE) consensus motif; other site
859656010119	AMP binding site [chemical binding]; other site
859656010120	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656010121	Condensation domain; Region: Condensation; pfam00668
859656010122	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656010123	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
859656010124	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859656010125	acyl-activating enzyme (AAE) consensus motif; other site
859656010126	AMP binding site [chemical binding]; other site
859656010127	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656010128	Condensation domain; Region: Condensation; pfam00668
859656010129	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656010130	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
859656010131	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859656010132	acyl-activating enzyme (AAE) consensus motif; other site
859656010133	AMP binding site [chemical binding]; other site
859656010134	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656010135	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
859656010136	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
859656010137	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859656010138	acyl-activating enzyme (AAE) consensus motif; other site
859656010139	AMP binding site [chemical binding]; other site
859656010140	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656010141	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
859656010142	ligand-binding site [chemical binding]; other site
859656010143	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
859656010144	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
859656010145	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
859656010146	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656010147	catalytic residue [active]
859656010148	Methyltransferase domain; Region: Methyltransf_31; pfam13847
859656010149	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656010150	S-adenosylmethionine binding site [chemical binding]; other site
859656010151	Evidence 4 : Homologs of previously reported genes of unknown function
859656010152	Evidence 4 : Homologs of previously reported genes of unknown function
859656010153	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859656010154	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859656010155	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859656010156	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859656010157	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859656010158	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
859656010159	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
859656010160	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
859656010161	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
859656010162	putative hydrophobic ligand binding site [chemical binding]; other site
859656010163	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
859656010164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656010165	putative substrate translocation pore; other site
859656010166	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
859656010167	aconitate hydratase; Provisional; Region: acnA; PRK12881
859656010168	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
859656010169	substrate binding site [chemical binding]; other site
859656010170	ligand binding site [chemical binding]; other site
859656010171	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
859656010172	substrate binding site [chemical binding]; other site
859656010173	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656010174	DNA-binding site [nucleotide binding]; DNA binding site
859656010175	Transcriptional regulators [Transcription]; Region: GntR; COG1802
859656010176	FCD domain; Region: FCD; pfam07729
859656010177	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656010178	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
859656010179	substrate binding pocket [chemical binding]; other site
859656010180	membrane-bound complex binding site; other site
859656010181	hinge residues; other site
859656010182	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859656010183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656010184	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
859656010185	putative substrate translocation pore; other site
859656010186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859656010187	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859656010188	active site
859656010189	catalytic tetrad [active]
859656010190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656010191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656010192	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859656010193	putative dimerization interface [polypeptide binding]; other site
859656010194	putative effector binding pocket; other site
859656010195	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
859656010196	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859656010197	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
859656010198	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
859656010199	dimer interface [polypeptide binding]; other site
859656010200	active site
859656010201	CoA binding pocket [chemical binding]; other site
859656010202	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
859656010203	chorismate mutase; Provisional; Region: PRK09269
859656010204	Chorismate mutase type II; Region: CM_2; cl00693
859656010205	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
859656010206	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
859656010207	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
859656010208	AMP nucleosidase; Provisional; Region: PRK08292
859656010209	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
859656010210	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
859656010211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
859656010212	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656010213	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656010214	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656010215	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656010216	dimer interface [polypeptide binding]; other site
859656010217	phosphorylation site [posttranslational modification]
859656010218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656010219	ATP binding site [chemical binding]; other site
859656010220	Mg2+ binding site [ion binding]; other site
859656010221	G-X-G motif; other site
859656010222	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
859656010223	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656010224	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859656010225	substrate binding pocket [chemical binding]; other site
859656010226	dimerization interface [polypeptide binding]; other site
859656010227	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
859656010228	Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532
859656010229	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
859656010230	alpha subunit interface [polypeptide binding]; other site
859656010231	active site
859656010232	substrate binding site [chemical binding]; other site
859656010233	Fe binding site [ion binding]; other site
859656010234	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656010235	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656010236	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859656010237	Uncharacterized conserved protein [Function unknown]; Region: COG1262
859656010238	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656010239	MarR family; Region: MarR; pfam01047
859656010240	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
859656010241	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656010242	substrate binding site [chemical binding]; other site
859656010243	oxyanion hole (OAH) forming residues; other site
859656010244	trimer interface [polypeptide binding]; other site
859656010245	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656010246	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
859656010247	NAD(P) binding site [chemical binding]; other site
859656010248	catalytic residues [active]
859656010249	feruloyl-CoA synthase; Reviewed; Region: PRK08180
859656010250	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
859656010251	acyl-activating enzyme (AAE) consensus motif; other site
859656010252	putative AMP binding site [chemical binding]; other site
859656010253	putative active site [active]
859656010254	putative CoA binding site [chemical binding]; other site
859656010255	Activator of aromatic catabolism; Region: XylR_N; pfam06505
859656010256	V4R domain; Region: V4R; pfam02830
859656010257	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
859656010258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656010259	Walker A motif; other site
859656010260	ATP binding site [chemical binding]; other site
859656010261	Walker B motif; other site
859656010262	arginine finger; other site
859656010263	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656010264	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656010265	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
859656010266	NAD(P) binding site [chemical binding]; other site
859656010267	catalytic residues [active]
859656010268	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
859656010269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656010270	NAD(P) binding site [chemical binding]; other site
859656010271	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
859656010272	active site
859656010273	Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313
859656010274	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859656010275	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859656010276	Protein of unknown function, DUF393; Region: DUF393; pfam04134
859656010277	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
859656010278	Beta-lactamase; Region: Beta-lactamase; pfam00144
859656010279	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
859656010280	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656010281	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656010282	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
859656010283	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656010284	active site
859656010285	benzoate transport; Region: 2A0115; TIGR00895
859656010286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656010287	putative substrate translocation pore; other site
859656010288	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
859656010289	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
859656010290	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
859656010291	active site
859656010292	catalytic site [active]
859656010293	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
859656010294	putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507
859656010295	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
859656010296	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
859656010297	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
859656010298	catalytic site [active]
859656010299	active site
859656010300	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
859656010301	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
859656010302	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
859656010303	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
859656010304	active site
859656010305	catalytic site [active]
859656010306	glycogen branching enzyme; Provisional; Region: PRK05402
859656010307	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
859656010308	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
859656010309	active site
859656010310	catalytic site [active]
859656010311	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
859656010312	trehalose synthase; Region: treS_nterm; TIGR02456
859656010313	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
859656010314	active site
859656010315	catalytic site [active]
859656010316	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
859656010317	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
859656010318	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
859656010319	active site
859656010320	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
859656010321	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
859656010322	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
859656010323	active site
859656010324	homodimer interface [polypeptide binding]; other site
859656010325	catalytic site [active]
859656010326	acceptor binding site [chemical binding]; other site
859656010327	glycogen synthase; Provisional; Region: glgA; PRK00654
859656010328	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
859656010329	ADP-binding pocket [chemical binding]; other site
859656010330	homodimer interface [polypeptide binding]; other site
859656010331	peroxiredoxin; Region: AhpC; TIGR03137
859656010332	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
859656010333	dimer interface [polypeptide binding]; other site
859656010334	decamer (pentamer of dimers) interface [polypeptide binding]; other site
859656010335	catalytic triad [active]
859656010336	peroxidatic and resolving cysteines [active]
859656010337	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
859656010338	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
859656010339	catalytic residue [active]
859656010340	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
859656010341	catalytic residues [active]
859656010342	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859656010343	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656010344	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
859656010345	metal binding site 2 [ion binding]; metal-binding site
859656010346	putative DNA binding helix; other site
859656010347	metal binding site 1 [ion binding]; metal-binding site
859656010348	dimer interface [polypeptide binding]; other site
859656010349	structural Zn2+ binding site [ion binding]; other site
859656010350	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
859656010351	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
859656010352	G1 box; other site
859656010353	GTP/Mg2+ binding site [chemical binding]; other site
859656010354	Switch I region; other site
859656010355	G2 box; other site
859656010356	G3 box; other site
859656010357	Switch II region; other site
859656010358	G4 box; other site
859656010359	G5 box; other site
859656010360	Nucleoside recognition; Region: Gate; pfam07670
859656010361	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
859656010362	Nucleoside recognition; Region: Gate; pfam07670
859656010363	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
859656010364	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859656010365	PAS fold; Region: PAS; pfam00989
859656010366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010367	putative active site [active]
859656010368	heme pocket [chemical binding]; other site
859656010369	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010370	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010371	metal binding site [ion binding]; metal-binding site
859656010372	active site
859656010373	I-site; other site
859656010374	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656010375	dimerization interface [polypeptide binding]; other site
859656010376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010377	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859656010378	putative active site [active]
859656010379	heme pocket [chemical binding]; other site
859656010380	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010381	putative active site [active]
859656010382	heme pocket [chemical binding]; other site
859656010383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010384	PAS domain; Region: PAS_9; pfam13426
859656010385	putative active site [active]
859656010386	heme pocket [chemical binding]; other site
859656010387	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010388	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010389	metal binding site [ion binding]; metal-binding site
859656010390	active site
859656010391	I-site; other site
859656010392	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656010393	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010394	PAS fold; Region: PAS_3; pfam08447
859656010395	putative active site [active]
859656010396	heme pocket [chemical binding]; other site
859656010397	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
859656010398	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859656010399	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656010400	dimer interface [polypeptide binding]; other site
859656010401	putative CheW interface [polypeptide binding]; other site
859656010402	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
859656010403	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
859656010404	FAD binding pocket [chemical binding]; other site
859656010405	FAD binding motif [chemical binding]; other site
859656010406	phosphate binding motif [ion binding]; other site
859656010407	NAD binding pocket [chemical binding]; other site
859656010408	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
859656010409	Predicted transcriptional regulators [Transcription]; Region: COG1695
859656010410	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
859656010411	putative substrate binding pocket [chemical binding]; other site
859656010412	AC domain interface; other site
859656010413	catalytic triad [active]
859656010414	AB domain interface; other site
859656010415	interchain disulfide; other site
859656010416	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859656010417	MarR family; Region: MarR_2; pfam12802
859656010418	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
859656010419	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
859656010420	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
859656010421	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
859656010422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656010423	Coenzyme A binding pocket [chemical binding]; other site
859656010424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
859656010425	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
859656010426	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
859656010427	glutamate carboxypeptidase; Reviewed; Region: PRK06133
859656010428	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
859656010429	metal binding site [ion binding]; metal-binding site
859656010430	dimer interface [polypeptide binding]; other site
859656010431	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
859656010432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859656010433	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
859656010434	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
859656010435	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
859656010436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656010437	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656010438	putative substrate translocation pore; other site
859656010439	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859656010440	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
859656010441	putative NAD(P) binding site [chemical binding]; other site
859656010442	putative substrate binding site [chemical binding]; other site
859656010443	catalytic Zn binding site [ion binding]; other site
859656010444	structural Zn binding site [ion binding]; other site
859656010445	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
859656010446	Transcriptional activator [Transcription]; Region: ChrR; COG3806
859656010447	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
859656010448	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
859656010449	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859656010450	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
859656010451	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
859656010452	classical (c) SDRs; Region: SDR_c; cd05233
859656010453	NAD(P) binding site [chemical binding]; other site
859656010454	active site
859656010455	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859656010456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656010457	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859656010458	dimerization interface [polypeptide binding]; other site
859656010459	substrate binding pocket [chemical binding]; other site
859656010460	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
859656010461	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
859656010462	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
859656010463	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
859656010464	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
859656010465	active site
859656010466	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
859656010467	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
859656010468	putative NAD(P) binding site [chemical binding]; other site
859656010469	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
859656010470	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656010471	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656010472	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656010473	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656010474	putative effector binding pocket; other site
859656010475	dimerization interface [polypeptide binding]; other site
859656010476	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
859656010477	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
859656010478	dimer interface [polypeptide binding]; other site
859656010479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656010480	catalytic residue [active]
859656010481	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
859656010482	Trehalase; Region: Trehalase; cl17346
859656010483	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
859656010484	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
859656010485	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859656010486	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
859656010487	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
859656010488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656010489	binding surface
859656010490	TPR motif; other site
859656010491	TPR repeat; Region: TPR_11; pfam13414
859656010492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656010493	binding surface
859656010494	TPR motif; other site
859656010495	TPR repeat; Region: TPR_11; pfam13414
859656010496	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
859656010497	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
859656010498	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
859656010499	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656010500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
859656010501	active site
859656010502	phosphorylation site [posttranslational modification]
859656010503	dimerization interface [polypeptide binding]; other site
859656010504	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656010505	DNA binding residues [nucleotide binding]
859656010506	dimerization interface [polypeptide binding]; other site
859656010507	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
859656010508	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
859656010509	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
859656010510	putative active site [active]
859656010511	putative metal binding site [ion binding]; other site
859656010512	N-glycosyltransferase; Provisional; Region: PRK11204
859656010513	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
859656010514	DXD motif; other site
859656010515	PgaD-like protein; Region: PgaD; cl14676
859656010516	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859656010517	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859656010518	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
859656010519	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656010520	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656010521	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
859656010522	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
859656010523	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859656010524	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656010525	Walker A/P-loop; other site
859656010526	ATP binding site [chemical binding]; other site
859656010527	Q-loop/lid; other site
859656010528	ABC transporter signature motif; other site
859656010529	Walker B; other site
859656010530	D-loop; other site
859656010531	H-loop/switch region; other site
859656010532	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
859656010533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656010534	Coenzyme A binding pocket [chemical binding]; other site
859656010535	Tar ligand binding domain homologue; Region: TarH; pfam02203
859656010536	dimer interface [polypeptide binding]; other site
859656010537	ligand binding site [chemical binding]; other site
859656010538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656010539	dimerization interface [polypeptide binding]; other site
859656010540	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656010541	dimer interface [polypeptide binding]; other site
859656010542	putative CheW interface [polypeptide binding]; other site
859656010543	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
859656010544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656010545	NAD(P) binding site [chemical binding]; other site
859656010546	active site
859656010547	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
859656010548	CGNR zinc finger; Region: zf-CGNR; pfam11706
859656010549	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859656010550	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859656010551	FMN binding site [chemical binding]; other site
859656010552	substrate binding site [chemical binding]; other site
859656010553	putative catalytic residue [active]
859656010554	LysR family transcriptional regulator; Provisional; Region: PRK14997
859656010555	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656010556	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656010557	dimerization interface [polypeptide binding]; other site
859656010558	Predicted transcriptional regulators [Transcription]; Region: COG1695
859656010559	Transcriptional regulator PadR-like family; Region: PadR; cl17335
859656010560	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
859656010561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656010562	H+ Antiporter protein; Region: 2A0121; TIGR00900
859656010563	putative substrate translocation pore; other site
859656010564	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
859656010565	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
859656010566	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656010567	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656010568	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656010569	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656010570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656010571	active site
859656010572	phosphorylation site [posttranslational modification]
859656010573	intermolecular recognition site; other site
859656010574	dimerization interface [polypeptide binding]; other site
859656010575	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656010576	DNA binding site [nucleotide binding]
859656010577	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656010578	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859656010579	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656010580	dimer interface [polypeptide binding]; other site
859656010581	phosphorylation site [posttranslational modification]
859656010582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656010583	Mg2+ binding site [ion binding]; other site
859656010584	G-X-G motif; other site
859656010585	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
859656010586	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
859656010587	FMN binding site [chemical binding]; other site
859656010588	substrate binding site [chemical binding]; other site
859656010589	putative catalytic residue [active]
859656010590	SnoaL-like domain; Region: SnoaL_2; pfam12680
859656010591	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656010592	Ligand Binding Site [chemical binding]; other site
859656010593	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
859656010594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656010595	Walker A/P-loop; other site
859656010596	ATP binding site [chemical binding]; other site
859656010597	Q-loop/lid; other site
859656010598	ABC transporter signature motif; other site
859656010599	Walker B; other site
859656010600	D-loop; other site
859656010601	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
859656010602	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859656010603	Soluble P-type ATPase [General function prediction only]; Region: COG4087
859656010604	conserved hypothetical protein; Region: TIGR02231
859656010605	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
859656010606	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
859656010607	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
859656010608	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
859656010609	DNA binding residues [nucleotide binding]
859656010610	dimer interface [polypeptide binding]; other site
859656010611	putative metal binding site [ion binding]; other site
859656010612	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
859656010613	dimerization interface [polypeptide binding]; other site
859656010614	2-isopropylmalate synthase; Validated; Region: PRK03739
859656010615	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
859656010616	active site
859656010617	catalytic residues [active]
859656010618	metal binding site [ion binding]; metal-binding site
859656010619	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
859656010620	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
859656010621	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656010622	catalytic loop [active]
859656010623	iron binding site [ion binding]; other site
859656010624	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
859656010625	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
859656010626	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
859656010627	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
859656010628	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
859656010629	Ligand binding site; other site
859656010630	metal-binding site
859656010631	Putative cyclase; Region: Cyclase; pfam04199
859656010632	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656010633	MULE transposase domain; Region: MULE; pfam10551
859656010634	PAS fold; Region: PAS_4; pfam08448
859656010635	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010636	putative active site [active]
859656010637	heme pocket [chemical binding]; other site
859656010638	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010640	metal binding site [ion binding]; metal-binding site
859656010641	active site
859656010642	I-site; other site
859656010643	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656010644	H-NS histone family; Region: Histone_HNS; pfam00816
859656010645	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859656010646	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859656010647	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656010648	DNA-binding site [nucleotide binding]; DNA binding site
859656010649	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
859656010650	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656010651	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656010652	trimer interface [polypeptide binding]; other site
859656010653	eyelet of channel; other site
859656010654	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656010655	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656010656	DNA binding residues [nucleotide binding]
859656010657	dimerization interface [polypeptide binding]; other site
859656010658	FlgN protein; Region: FlgN; pfam05130
859656010659	Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747
859656010660	SAF-like; Region: SAF_2; pfam13144
859656010661	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
859656010662	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
859656010663	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
859656010664	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
859656010665	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
859656010666	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859656010667	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
859656010668	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
859656010669	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
859656010670	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
859656010671	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
859656010672	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859656010673	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
859656010674	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
859656010675	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
859656010676	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
859656010677	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
859656010678	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
859656010679	Flagellar L-ring protein; Region: FlgH; pfam02107
859656010680	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
859656010681	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
859656010682	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
859656010683	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
859656010684	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
859656010685	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
859656010686	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
859656010687	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
859656010688	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
859656010689	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
859656010690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656010691	S-adenosylmethionine binding site [chemical binding]; other site
859656010692	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859656010693	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
859656010694	dimer interface [polypeptide binding]; other site
859656010695	active site
859656010696	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
859656010697	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859656010698	dimer interface [polypeptide binding]; other site
859656010699	active site
859656010700	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
859656010701	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
859656010702	NAD(P) binding site [chemical binding]; other site
859656010703	homotetramer interface [polypeptide binding]; other site
859656010704	homodimer interface [polypeptide binding]; other site
859656010705	active site
859656010706	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
859656010707	putative active site 1 [active]
859656010708	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
859656010709	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
859656010710	dimer interface [polypeptide binding]; other site
859656010711	active site
859656010712	Predicted exporter [General function prediction only]; Region: COG4258
859656010713	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
859656010714	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
859656010715	active site
859656010716	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
859656010717	active sites [active]
859656010718	tetramer interface [polypeptide binding]; other site
859656010719	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
859656010720	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
859656010721	Ligand binding site; other site
859656010722	Putative Catalytic site; other site
859656010723	DXD motif; other site
859656010724	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
859656010725	putative acyl-acceptor binding pocket; other site
859656010726	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859656010727	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656010728	AMP binding site [chemical binding]; other site
859656010729	active site
859656010730	acyl-activating enzyme (AAE) consensus motif; other site
859656010731	CoA binding site [chemical binding]; other site
859656010732	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
859656010733	active site 2 [active]
859656010734	dimer interface [polypeptide binding]; other site
859656010735	active site 1 [active]
859656010736	Predicted membrane protein [Function unknown]; Region: COG4648
859656010737	acyl carrier protein; Provisional; Region: PRK05350
859656010738	Phosphopantetheine attachment site; Region: PP-binding; cl09936
859656010739	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859656010740	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
859656010741	putative acyl-acceptor binding pocket; other site
859656010742	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
859656010743	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
859656010744	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
859656010745	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
859656010746	Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190
859656010747	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
859656010748	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
859656010749	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
859656010750	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
859656010751	PAS fold; Region: PAS_4; pfam08448
859656010752	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656010753	putative active site [active]
859656010754	heme pocket [chemical binding]; other site
859656010755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010757	metal binding site [ion binding]; metal-binding site
859656010758	active site
859656010759	I-site; other site
859656010760	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656010761	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656010762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656010763	active site
859656010764	phosphorylation site [posttranslational modification]
859656010765	intermolecular recognition site; other site
859656010766	dimerization interface [polypeptide binding]; other site
859656010767	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656010768	DNA binding residues [nucleotide binding]
859656010769	dimerization interface [polypeptide binding]; other site
859656010770	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
859656010771	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
859656010772	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
859656010773	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
859656010774	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
859656010775	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
859656010776	Flagellar protein FliT; Region: FliT; pfam05400
859656010777	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656010778	MarR family; Region: MarR; pfam01047
859656010779	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
859656010780	putative metal binding site; other site
859656010781	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
859656010782	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
859656010783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
859656010784	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
859656010785	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
859656010786	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
859656010787	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
859656010788	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
859656010789	FliG C-terminal domain; Region: FliG_C; pfam01706
859656010790	flagellar assembly protein H; Validated; Region: fliH; PRK05687
859656010791	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
859656010792	Flagellar assembly protein FliH; Region: FliH; pfam02108
859656010793	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
859656010794	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
859656010795	Walker A motif/ATP binding site; other site
859656010796	Walker B motif; other site
859656010797	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
859656010798	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
859656010799	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
859656010800	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
859656010801	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
859656010802	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
859656010803	active site residue [active]
859656010804	Cache domain; Region: Cache_1; pfam02743
859656010805	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010806	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010807	metal binding site [ion binding]; metal-binding site
859656010808	active site
859656010809	I-site; other site
859656010810	TPR repeat; Region: TPR_11; pfam13414
859656010811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656010812	TPR motif; other site
859656010813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656010814	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656010815	metal binding site [ion binding]; metal-binding site
859656010816	active site
859656010817	I-site; other site
859656010818	BON domain; Region: BON; pfam04972
859656010819	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
859656010820	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
859656010821	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
859656010822	Predicted membrane protein [Function unknown]; Region: COG4291
859656010823	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
859656010824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656010825	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656010826	putative substrate translocation pore; other site
859656010827	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
859656010828	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859656010829	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656010830	N-terminal plug; other site
859656010831	ligand-binding site [chemical binding]; other site
859656010832	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
859656010833	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656010834	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656010835	DNA binding residues [nucleotide binding]
859656010836	Secretin and TonB N terminus short domain; Region: STN; smart00965
859656010837	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656010838	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859656010839	N-terminal plug; other site
859656010840	ligand-binding site [chemical binding]; other site
859656010841	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
859656010842	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
859656010843	dimer interface [polypeptide binding]; other site
859656010844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656010845	catalytic residue [active]
859656010846	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
859656010847	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
859656010848	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
859656010849	IucA / IucC family; Region: IucA_IucC; pfam04183
859656010850	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
859656010851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
859656010852	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
859656010853	IucA / IucC family; Region: IucA_IucC; pfam04183
859656010854	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
859656010855	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
859656010856	IucA / IucC family; Region: IucA_IucC; pfam04183
859656010857	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
859656010858	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
859656010859	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
859656010860	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
859656010861	dimer interface [polypeptide binding]; other site
859656010862	active site
859656010863	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656010864	catalytic residues [active]
859656010865	substrate binding site [chemical binding]; other site
859656010866	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
859656010867	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
859656010868	RNA ligase; Region: RNA_ligase; pfam09414
859656010869	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
859656010870	Zn2+ binding site [ion binding]; other site
859656010871	Mg2+ binding site [ion binding]; other site
859656010872	AAA domain; Region: AAA_33; pfam13671
859656010873	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010874	RHS Repeat; Region: RHS_repeat; pfam05593
859656010875	RHS Repeat; Region: RHS_repeat; pfam05593
859656010876	RHS Repeat; Region: RHS_repeat; pfam05593
859656010877	RHS Repeat; Region: RHS_repeat; pfam05593
859656010878	RHS Repeat; Region: RHS_repeat; cl11982
859656010879	RHS Repeat; Region: RHS_repeat; pfam05593
859656010880	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010881	RHS Repeat; Region: RHS_repeat; pfam05593
859656010882	RHS Repeat; Region: RHS_repeat; pfam05593
859656010883	RHS Repeat; Region: RHS_repeat; pfam05593
859656010884	RHS Repeat; Region: RHS_repeat; pfam05593
859656010885	RHS Repeat; Region: RHS_repeat; cl11982
859656010886	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010887	RHS Repeat; Region: RHS_repeat; pfam05593
859656010888	RHS Repeat; Region: RHS_repeat; pfam05593
859656010889	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010890	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656010891	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656010892	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656010893	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
859656010894	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
859656010895	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
859656010896	Walker A motif; other site
859656010897	ATP binding site [chemical binding]; other site
859656010898	Walker B motif; other site
859656010899	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
859656010900	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656010901	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656010902	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
859656010903	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656010904	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
859656010905	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
859656010906	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656010907	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
859656010908	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
859656010909	Secretin and TonB N terminus short domain; Region: STN; smart00965
859656010910	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656010911	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656010912	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
859656010913	dockerin binding interface; other site
859656010914	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010915	RHS Repeat; Region: RHS_repeat; pfam05593
859656010916	RHS Repeat; Region: RHS_repeat; pfam05593
859656010917	RHS Repeat; Region: RHS_repeat; pfam05593
859656010918	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
859656010919	RHS Repeat; Region: RHS_repeat; cl11982
859656010920	RHS Repeat; Region: RHS_repeat; cl11982
859656010921	RHS Repeat; Region: RHS_repeat; cl11982
859656010922	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859656010923	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010924	RHS Repeat; Region: RHS_repeat; pfam05593
859656010925	RHS Repeat; Region: RHS_repeat; pfam05593
859656010926	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010927	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010928	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010929	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
859656010930	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859656010931	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010932	RHS Repeat; Region: RHS_repeat; pfam05593
859656010933	RHS Repeat; Region: RHS_repeat; pfam05593
859656010934	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010935	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656010936	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010937	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656010938	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656010939	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
859656010940	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656010941	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859656010942	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656010943	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656010944	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859656010945	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859656010946	Walker A/P-loop; other site
859656010947	ATP binding site [chemical binding]; other site
859656010948	Q-loop/lid; other site
859656010949	ABC transporter signature motif; other site
859656010950	Walker B; other site
859656010951	D-loop; other site
859656010952	H-loop/switch region; other site
859656010953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656010954	dimer interface [polypeptide binding]; other site
859656010955	conserved gate region; other site
859656010956	putative PBP binding loops; other site
859656010957	ABC-ATPase subunit interface; other site
859656010958	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656010959	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656010960	substrate binding pocket [chemical binding]; other site
859656010961	membrane-bound complex binding site; other site
859656010962	hinge residues; other site
859656010963	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656010964	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
859656010965	putative DNA binding site [nucleotide binding]; other site
859656010966	putative Zn2+ binding site [ion binding]; other site
859656010967	AsnC family; Region: AsnC_trans_reg; pfam01037
859656010968	ornithine cyclodeaminase; Validated; Region: PRK07589
859656010969	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
859656010970	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
859656010971	Amidinotransferase; Region: Amidinotransf; pfam02274
859656010972	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
859656010973	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656010974	motif II; other site
859656010975	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
859656010976	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
859656010977	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656010978	active site
859656010979	hypothetical protein; Provisional; Region: PRK08262
859656010980	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
859656010981	metal binding site [ion binding]; metal-binding site
859656010982	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
859656010983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656010984	dimer interface [polypeptide binding]; other site
859656010985	phosphorylation site [posttranslational modification]
859656010986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656010987	ATP binding site [chemical binding]; other site
859656010988	Mg2+ binding site [ion binding]; other site
859656010989	G-X-G motif; other site
859656010990	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
859656010991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656010992	active site
859656010993	phosphorylation site [posttranslational modification]
859656010994	intermolecular recognition site; other site
859656010995	dimerization interface [polypeptide binding]; other site
859656010996	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656010997	DNA binding site [nucleotide binding]
859656010998	Outer membrane efflux protein; Region: OEP; pfam02321
859656010999	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
859656011000	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
859656011001	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
859656011002	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859656011003	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656011004	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
859656011005	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656011006	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
859656011007	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
859656011008	nucleotide binding site/active site [active]
859656011009	HIT family signature motif; other site
859656011010	catalytic residue [active]
859656011011	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
859656011012	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
859656011013	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859656011014	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
859656011015	putative ligand binding site [chemical binding]; other site
859656011016	NAD binding site [chemical binding]; other site
859656011017	catalytic site [active]
859656011018	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656011019	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
859656011020	dimer interface [polypeptide binding]; other site
859656011021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656011022	dimerization interface [polypeptide binding]; other site
859656011023	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656011024	dimer interface [polypeptide binding]; other site
859656011025	putative CheW interface [polypeptide binding]; other site
859656011026	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
859656011027	active site
859656011028	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
859656011029	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
859656011030	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
859656011031	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
859656011032	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
859656011033	active site
859656011034	homodimer interface [polypeptide binding]; other site
859656011035	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
859656011036	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
859656011037	NodB motif; other site
859656011038	putative active site [active]
859656011039	putative catalytic site [active]
859656011040	putative Zn binding site [ion binding]; other site
859656011041	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
859656011042	Mechanosensitive ion channel; Region: MS_channel; pfam00924
859656011043	Uncharacterized conserved protein [Function unknown]; Region: COG4104
859656011044	Protein of unknown function (DUF2875); Region: DUF2875; pfam11394
859656011045	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
859656011046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656011047	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656011048	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656011049	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656011050	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
859656011051	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656011052	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656011053	metal binding site [ion binding]; metal-binding site
859656011054	active site
859656011055	I-site; other site
859656011056	manganese transport protein MntH; Reviewed; Region: PRK00701
859656011057	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
859656011058	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
859656011059	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
859656011060	nucleotide binding site [chemical binding]; other site
859656011061	putative NEF/HSP70 interaction site [polypeptide binding]; other site
859656011062	SBD interface [polypeptide binding]; other site
859656011063	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
859656011064	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
859656011065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656011066	active site
859656011067	phosphorylation site [posttranslational modification]
859656011068	intermolecular recognition site; other site
859656011069	dimerization interface [polypeptide binding]; other site
859656011070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656011071	DNA binding site [nucleotide binding]
859656011072	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656011073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
859656011074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656011075	ATP binding site [chemical binding]; other site
859656011076	Mg2+ binding site [ion binding]; other site
859656011077	G-X-G motif; other site
859656011078	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
859656011079	NADH(P)-binding; Region: NAD_binding_10; pfam13460
859656011080	NAD binding site [chemical binding]; other site
859656011081	putative active site [active]
859656011082	substrate binding site [chemical binding]; other site
859656011083	Predicted transcriptional regulator [Transcription]; Region: COG1959
859656011084	Transcriptional regulator; Region: Rrf2; pfam02082
859656011085	Transcriptional regulator; Region: Rrf2; cl17282
859656011086	Outer membrane efflux protein; Region: OEP; pfam02321
859656011087	Outer membrane efflux protein; Region: OEP; pfam02321
859656011088	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656011089	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656011090	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656011091	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859656011092	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859656011093	Peptidase family M1; Region: Peptidase_M1; pfam01433
859656011094	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
859656011095	Zn binding site [ion binding]; other site
859656011096	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
859656011097	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656011098	active site
859656011099	metal binding site [ion binding]; metal-binding site
859656011100	hexamer interface [polypeptide binding]; other site
859656011101	High-affinity nickel-transport protein; Region: NicO; cl00964
859656011102	High-affinity nickel-transport protein; Region: NicO; cl00964
859656011103	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
859656011104	putative metal binding site [ion binding]; other site
859656011105	putative homodimer interface [polypeptide binding]; other site
859656011106	putative homotetramer interface [polypeptide binding]; other site
859656011107	putative homodimer-homodimer interface [polypeptide binding]; other site
859656011108	putative allosteric switch controlling residues; other site
859656011109	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
859656011110	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
859656011111	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
859656011112	Chromate transporter; Region: Chromate_transp; pfam02417
859656011113	Uncharacterized conserved protein [Function unknown]; Region: COG4275
859656011114	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
859656011115	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656011116	Coenzyme A binding pocket [chemical binding]; other site
859656011117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656011118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011119	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656011120	dimerization interface [polypeptide binding]; other site
859656011121	hypothetical protein; Validated; Region: PRK09169
859656011122	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859656011123	metal binding triad [ion binding]; metal-binding site
859656011124	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656011125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011126	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656011127	dimerization interface [polypeptide binding]; other site
859656011128	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
859656011129	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859656011130	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656011131	Evidence 4 : Homologs of previously reported genes of unknown function
859656011132	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656011133	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
859656011134	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
859656011135	Low-spin heme binding site [chemical binding]; other site
859656011136	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
859656011137	D-pathway; other site
859656011138	Putative water exit pathway; other site
859656011139	Binuclear center (active site) [active]
859656011140	K-pathway; other site
859656011141	Putative proton exit pathway; other site
859656011142	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
859656011143	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
859656011144	Cytochrome c; Region: Cytochrom_C; pfam00034
859656011145	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
859656011146	Cu(I) binding site [ion binding]; other site
859656011147	putative transposase OrfB; Reviewed; Region: PHA02517
859656011148	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859656011149	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011150	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
859656011151	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656011152	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656011153	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component
859656011154	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859656011155	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859656011156	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859656011157	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
859656011158	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
859656011159	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor
859656011160	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656011161	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656011162	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656011163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656011164	non-specific DNA binding site [nucleotide binding]; other site
859656011165	salt bridge; other site
859656011166	sequence-specific DNA binding site [nucleotide binding]; other site
859656011167	Predicted membrane protein [Function unknown]; Region: COG4541
859656011168	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
859656011169	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656011170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656011171	putative DNA binding site [nucleotide binding]; other site
859656011172	putative Zn2+ binding site [ion binding]; other site
859656011173	AsnC family; Region: AsnC_trans_reg; pfam01037
859656011174	Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297
859656011175	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
859656011176	CBD_II domain; Region: CBD_II; smart00637
859656011177	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656011178	Fic family protein [Function unknown]; Region: COG3177
859656011179	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
859656011180	Fic/DOC family; Region: Fic; pfam02661
859656011181	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859656011182	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
859656011183	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011184	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011185	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011186	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011187	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011188	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
859656011189	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859656011190	Evidence 4 : Homologs of previously reported genes of unknown function
859656011191	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859656011192	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859656011193	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859656011194	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656011195	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859656011196	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859656011197	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859656011198	Evidence 4 : Homologs of previously reported genes of unknown function
859656011199	Transposase; Region: HTH_Tnp_1; cl17663
859656011200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
859656011201	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
859656011202	HTH-like domain; Region: HTH_21; pfam13276
859656011203	Integrase core domain; Region: rve; pfam00665
859656011204	Integrase core domain; Region: rve_3; pfam13683
859656011205	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656011206	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656011207	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656011208	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656011209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656011210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656011211	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656011212	short chain dehydrogenase; Provisional; Region: PRK06179
859656011213	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
859656011214	NADP binding site [chemical binding]; other site
859656011215	active site
859656011216	steroid binding site; other site
859656011217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656011218	active site
859656011219	putative phosphatase; Provisional; Region: PRK11587
859656011220	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
859656011221	Evidence 4 : Homologs of previously reported genes of unknown function
859656011222	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
859656011223	catalytic residues [active]
859656011224	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656011225	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
859656011226	catalytic residues [active]
859656011227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656011228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656011229	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
859656011230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656011231	Evidence 4 : Homologs of previously reported genes of unknown function
859656011232	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
859656011233	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859656011234	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656011235	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859656011236	putative ligand binding site [chemical binding]; other site
859656011237	citrate-proton symporter; Provisional; Region: PRK15075
859656011238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011239	putative substrate translocation pore; other site
859656011240	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859656011241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011242	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
859656011243	dimerization interface [polypeptide binding]; other site
859656011244	substrate binding pocket [chemical binding]; other site
859656011245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656011246	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656011247	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656011248	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656011249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859656011250	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656011251	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
859656011252	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656011253	putative active site [active]
859656011254	catalytic site [active]
859656011255	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656011256	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656011257	putative active site [active]
859656011258	catalytic site [active]
859656011259	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
859656011260	Sel1-like repeats; Region: SEL1; smart00671
859656011261	Evidence 4 : Homologs of previously reported genes of unknown function
859656011262	Evidence 4 : Homologs of previously reported genes of unknown function
859656011263	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
859656011264	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656011265	active site
859656011266	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
859656011267	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656011268	motif II; other site
859656011269	Evidence 4 : Homologs of previously reported genes of unknown function
859656011270	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
859656011271	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
859656011272	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
859656011273	catalytic residues [active]
859656011274	catalytic nucleophile [active]
859656011275	Presynaptic Site I dimer interface [polypeptide binding]; other site
859656011276	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
859656011277	Synaptic Flat tetramer interface [polypeptide binding]; other site
859656011278	Synaptic Site I dimer interface [polypeptide binding]; other site
859656011279	DNA binding site [nucleotide binding]
859656011280	Recombinase; Region: Recombinase; pfam07508
859656011281	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
859656011282	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
859656011283	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656011284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656011285	active site
859656011286	phosphorylation site [posttranslational modification]
859656011287	intermolecular recognition site; other site
859656011288	dimerization interface [polypeptide binding]; other site
859656011289	Evidence 4 : Homologs of previously reported genes of unknown function
859656011290	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656011291	WHG domain; Region: WHG; pfam13305
859656011292	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
859656011293	SnoaL-like domain; Region: SnoaL_3; pfam13474
859656011294	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
859656011295	dimer interface [polypeptide binding]; other site
859656011296	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656011297	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
859656011298	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859656011299	putative active site [active]
859656011300	putative catalytic triad [active]
859656011301	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
859656011302	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
859656011303	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
859656011304	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
859656011305	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
859656011306	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
859656011307	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
859656011308	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
859656011309	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
859656011310	FAD binding pocket [chemical binding]; other site
859656011311	FAD binding motif [chemical binding]; other site
859656011312	phosphate binding motif [ion binding]; other site
859656011313	beta-alpha-beta structure motif; other site
859656011314	NAD(p) ribose binding residues [chemical binding]; other site
859656011315	NAD binding pocket [chemical binding]; other site
859656011316	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
859656011317	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656011318	catalytic loop [active]
859656011319	iron binding site [ion binding]; other site
859656011320	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820
859656011321	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656011322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011323	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
859656011324	Predicted transcriptional regulators [Transcription]; Region: COG1733
859656011325	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859656011326	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
859656011327	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656011328	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656011329	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656011330	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
859656011331	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859656011332	active site residue [active]
859656011333	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
859656011334	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859656011335	active site residue [active]
859656011336	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859656011337	active site residue [active]
859656011338	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
859656011339	active site residue [active]
859656011340	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
859656011341	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859656011342	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656011343	catalytic residue [active]
859656011344	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
859656011345	putative FMN binding site [chemical binding]; other site
859656011346	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
859656011347	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
859656011348	catalytic triad [active]
859656011349	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
859656011350	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
859656011351	homodimer interface [polypeptide binding]; other site
859656011352	Walker A motif; other site
859656011353	ATP binding site [chemical binding]; other site
859656011354	hydroxycobalamin binding site [chemical binding]; other site
859656011355	Walker B motif; other site
859656011356	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
859656011357	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
859656011358	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
859656011359	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
859656011360	active site
859656011361	SAM binding site [chemical binding]; other site
859656011362	homodimer interface [polypeptide binding]; other site
859656011363	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
859656011364	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
859656011365	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
859656011366	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
859656011367	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
859656011368	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
859656011369	active site
859656011370	SAM binding site [chemical binding]; other site
859656011371	homodimer interface [polypeptide binding]; other site
859656011372	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
859656011373	active site
859656011374	SAM binding site [chemical binding]; other site
859656011375	homodimer interface [polypeptide binding]; other site
859656011376	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
859656011377	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
859656011378	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
859656011379	putative active site [active]
859656011380	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
859656011381	putative active site [active]
859656011382	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
859656011383	Precorrin-8X methylmutase; Region: CbiC; pfam02570
859656011384	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
859656011385	active site
859656011386	putative homodimer interface [polypeptide binding]; other site
859656011387	SAM binding site [chemical binding]; other site
859656011388	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
859656011389	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
859656011390	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
859656011391	metal ion-dependent adhesion site (MIDAS); other site
859656011392	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
859656011393	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
859656011394	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
859656011395	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
859656011396	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
859656011397	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
859656011398	dimer interface [polypeptide binding]; other site
859656011399	[2Fe-2S] cluster binding site [ion binding]; other site
859656011400	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
859656011401	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859656011402	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859656011403	Walker A/P-loop; other site
859656011404	ATP binding site [chemical binding]; other site
859656011405	Q-loop/lid; other site
859656011406	ABC transporter signature motif; other site
859656011407	Walker B; other site
859656011408	D-loop; other site
859656011409	H-loop/switch region; other site
859656011410	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656011411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656011412	dimer interface [polypeptide binding]; other site
859656011413	conserved gate region; other site
859656011414	putative PBP binding loops; other site
859656011415	ABC-ATPase subunit interface; other site
859656011416	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656011417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656011418	dimer interface [polypeptide binding]; other site
859656011419	conserved gate region; other site
859656011420	putative PBP binding loops; other site
859656011421	ABC-ATPase subunit interface; other site
859656011422	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656011423	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656011424	substrate binding pocket [chemical binding]; other site
859656011425	membrane-bound complex binding site; other site
859656011426	hinge residues; other site
859656011427	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
859656011428	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
859656011429	putative active site [active]
859656011430	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
859656011431	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
859656011432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656011433	dimerization interface [polypeptide binding]; other site
859656011434	putative DNA binding site [nucleotide binding]; other site
859656011435	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656011436	putative Zn2+ binding site [ion binding]; other site
859656011437	AsnC family; Region: AsnC_trans_reg; pfam01037
859656011438	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
859656011439	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
859656011440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656011441	catalytic residue [active]
859656011442	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
859656011443	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656011444	substrate binding site [chemical binding]; other site
859656011445	oxyanion hole (OAH) forming residues; other site
859656011446	trimer interface [polypeptide binding]; other site
859656011447	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
859656011448	enoyl-CoA hydratase; Provisional; Region: PRK09076
859656011449	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656011450	substrate binding site [chemical binding]; other site
859656011451	oxyanion hole (OAH) forming residues; other site
859656011452	trimer interface [polypeptide binding]; other site
859656011453	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
859656011454	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
859656011455	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
859656011456	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
859656011457	tetrameric interface [polypeptide binding]; other site
859656011458	NAD binding site [chemical binding]; other site
859656011459	catalytic residues [active]
859656011460	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859656011461	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
859656011462	active site
859656011463	acyl-activating enzyme (AAE) consensus motif; other site
859656011464	putative CoA binding site [chemical binding]; other site
859656011465	AMP binding site [chemical binding]; other site
859656011466	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656011467	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656011468	active site
859656011469	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
859656011470	Helix-turn-helix domain; Region: HTH_18; pfam12833
859656011471	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656011472	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
859656011473	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656011474	non-specific DNA binding site [nucleotide binding]; other site
859656011475	salt bridge; other site
859656011476	sequence-specific DNA binding site [nucleotide binding]; other site
859656011477	HipA N-terminal domain; Region: Couple_hipA; pfam13657
859656011478	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859656011479	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859656011480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011482	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859656011483	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656011484	putative DNA binding site [nucleotide binding]; other site
859656011485	putative Zn2+ binding site [ion binding]; other site
859656011486	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
859656011487	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
859656011488	oligomer interface [polypeptide binding]; other site
859656011489	metal binding site [ion binding]; metal-binding site
859656011490	metal binding site [ion binding]; metal-binding site
859656011491	putative Cl binding site [ion binding]; other site
859656011492	basic sphincter; other site
859656011493	hydrophobic gate; other site
859656011494	periplasmic entrance; other site
859656011495	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
859656011496	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
859656011497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011498	Uncharacterized conserved protein [Function unknown]; Region: COG5495
859656011499	Rossmann-like domain; Region: Rossmann-like; pfam10727
859656011500	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
859656011501	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
859656011502	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656011503	Protein export membrane protein; Region: SecD_SecF; cl14618
859656011504	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656011505	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
859656011506	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
859656011507	substrate binding site [chemical binding]; other site
859656011508	oxyanion hole (OAH) forming residues; other site
859656011509	trimer interface [polypeptide binding]; other site
859656011510	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656011511	Leucine-rich repeats; other site
859656011512	Substrate binding site [chemical binding]; other site
859656011513	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
859656011514	Leucine rich repeat; Region: LRR_8; pfam13855
859656011515	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656011516	Leucine-rich repeats; other site
859656011517	Substrate binding site [chemical binding]; other site
859656011518	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
859656011519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
859656011520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
859656011521	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
859656011522	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
859656011523	THF binding site; other site
859656011524	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
859656011525	substrate binding site [chemical binding]; other site
859656011526	THF binding site; other site
859656011527	zinc-binding site [ion binding]; other site
859656011528	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
859656011529	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656011530	putative DNA binding site [nucleotide binding]; other site
859656011531	putative Zn2+ binding site [ion binding]; other site
859656011532	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
859656011533	putative dimerization interface [polypeptide binding]; other site
859656011534	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
859656011535	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
859656011536	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
859656011537	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
859656011538	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
859656011539	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656011540	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
859656011541	active site
859656011542	ribulose/triose binding site [chemical binding]; other site
859656011543	phosphate binding site [ion binding]; other site
859656011544	substrate (anthranilate) binding pocket [chemical binding]; other site
859656011545	product (indole) binding pocket [chemical binding]; other site
859656011546	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
859656011547	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859656011548	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
859656011549	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
859656011550	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
859656011551	FMN binding site [chemical binding]; other site
859656011552	active site
859656011553	homodimer interface [polypeptide binding]; other site
859656011554	putative catalytic residue [active]
859656011555	4Fe-4S cluster binding site [ion binding]; other site
859656011556	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
859656011557	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
859656011558	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656011559	catalytic residue [active]
859656011560	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
859656011561	B3/4 domain; Region: B3_4; pfam03483
859656011562	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656011563	EamA-like transporter family; Region: EamA; pfam00892
859656011564	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
859656011565	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656011566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656011567	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011568	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
859656011569	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656011570	active site
859656011571	Predicted small integral membrane protein [Function unknown]; Region: COG5472
859656011572	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
859656011573	fumarylacetoacetase; Region: PLN02856
859656011574	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
859656011575	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
859656011576	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
859656011577	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656011578	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011579	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
859656011580	substrate binding pocket [chemical binding]; other site
859656011581	dimerization interface [polypeptide binding]; other site
859656011582	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
859656011583	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
859656011584	hypothetical protein; Reviewed; Region: PRK09588
859656011585	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
859656011586	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
859656011587	putative active site [active]
859656011588	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656011589	RHS Repeat; Region: RHS_repeat; cl11982
859656011590	RHS Repeat; Region: RHS_repeat; pfam05593
859656011591	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859656011592	RHS Repeat; Region: RHS_repeat; cl11982
859656011593	RHS Repeat; Region: RHS_repeat; pfam05593
859656011594	RHS Repeat; Region: RHS_repeat; cl11982
859656011595	RHS Repeat; Region: RHS_repeat; pfam05593
859656011596	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
859656011597	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
859656011598	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
859656011599	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
859656011600	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656011601	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
859656011602	Transcriptional regulator [Transcription]; Region: IclR; COG1414
859656011603	Bacterial transcriptional regulator; Region: IclR; pfam01614
859656011604	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656011605	TM-ABC transporter signature motif; other site
859656011606	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656011607	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656011608	TM-ABC transporter signature motif; other site
859656011609	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859656011610	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656011611	Walker A/P-loop; other site
859656011612	ATP binding site [chemical binding]; other site
859656011613	Q-loop/lid; other site
859656011614	ABC transporter signature motif; other site
859656011615	Walker B; other site
859656011616	D-loop; other site
859656011617	H-loop/switch region; other site
859656011618	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859656011619	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656011620	Walker A/P-loop; other site
859656011621	ATP binding site [chemical binding]; other site
859656011622	Q-loop/lid; other site
859656011623	ABC transporter signature motif; other site
859656011624	Walker B; other site
859656011625	D-loop; other site
859656011626	H-loop/switch region; other site
859656011627	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
859656011628	Cytochrome P450; Region: p450; cl12078
859656011629	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656011630	EamA-like transporter family; Region: EamA; pfam00892
859656011631	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
859656011632	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
859656011633	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
859656011634	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
859656011635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859656011636	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
859656011637	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
859656011638	homodimer interface [polypeptide binding]; other site
859656011639	substrate-cofactor binding pocket; other site
859656011640	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656011641	catalytic residue [active]
859656011642	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
859656011643	FMN-binding domain; Region: FMN_bind; pfam04205
859656011644	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
859656011645	nucleophilic elbow; other site
859656011646	catalytic triad; other site
859656011647	L-aspartate dehydrogenase; Provisional; Region: PRK13303
859656011648	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
859656011649	Domain of unknown function DUF108; Region: DUF108; pfam01958
859656011650	Evidence 4 : Homologs of previously reported genes of unknown function
859656011651	Uncharacterized conserved protein [Function unknown]; Region: COG3542
859656011652	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
859656011653	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
859656011654	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
859656011655	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
859656011656	active site
859656011657	homotetramer interface [polypeptide binding]; other site
859656011658	Evidence 4 : Homologs of previously reported genes of unknown function
859656011659	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859656011660	Evidence 4 : Homologs of previously reported genes of unknown function
859656011661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656011662	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656011663	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656011664	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656011665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859656011666	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
859656011667	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
859656011668	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
859656011669	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
859656011670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656011671	TPR motif; other site
859656011672	binding surface
859656011673	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
859656011674	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
859656011675	Protein of unknown function (DUF877); Region: DUF877; pfam05943
859656011676	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
859656011677	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
859656011678	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
859656011679	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
859656011680	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
859656011681	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
859656011682	Clp amino terminal domain; Region: Clp_N; pfam02861
859656011683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656011684	Walker A motif; other site
859656011685	ATP binding site [chemical binding]; other site
859656011686	Walker B motif; other site
859656011687	arginine finger; other site
859656011688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656011689	Walker A motif; other site
859656011690	ATP binding site [chemical binding]; other site
859656011691	Walker B motif; other site
859656011692	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
859656011693	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier
859656011694	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
859656011695	Evidence 4 : Homologs of previously reported genes of unknown function
859656011696	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
859656011697	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656011698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859656011699	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859656011700	NADH dehydrogenase; Region: NADHdh; cl00469
859656011701	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
859656011702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
859656011703	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
859656011704	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
859656011705	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
859656011706	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
859656011707	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859656011708	ligand binding site [chemical binding]; other site
859656011709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913
859656011710	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
859656011711	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
859656011712	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
859656011713	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
859656011714	PAAR motif; Region: PAAR_motif; pfam05488
859656011715	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
859656011716	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
859656011717	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656011718	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656011719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656011720	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656011721	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656011722	Evidence 4 : Homologs of previously reported genes of unknown function
859656011723	Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104
859656011724	putative active site [active]
859656011725	catalytic site [active]
859656011726	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
859656011727	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656011728	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins; Region: PLDc_vPLD1_2_yPLD_like_2; cd09141
859656011729	putative active site [active]
859656011730	catalytic site [active]
859656011731	Resistant to P. syringae 6; Provisional; Region: PLN03210
859656011732	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859656011733	aspartate aminotransferase; Provisional; Region: PRK06108
859656011734	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656011735	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656011736	homodimer interface [polypeptide binding]; other site
859656011737	catalytic residue [active]
859656011738	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656011739	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011740	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859656011741	dimerization interface [polypeptide binding]; other site
859656011742	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
859656011743	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
859656011744	Uncharacterized conserved protein [Function unknown]; Region: COG4544
859656011745	DNA Polymerase Y-family; Region: PolY_like; cd03468
859656011746	active site
859656011747	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
859656011748	DNA binding site [nucleotide binding]
859656011749	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
859656011750	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
859656011751	putative active site [active]
859656011752	putative PHP Thumb interface [polypeptide binding]; other site
859656011753	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
859656011754	generic binding surface II; other site
859656011755	generic binding surface I; other site
859656011756	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656011757	non-specific DNA binding site [nucleotide binding]; other site
859656011758	salt bridge; other site
859656011759	sequence-specific DNA binding site [nucleotide binding]; other site
859656011760	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
859656011761	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
859656011762	transmembrane helices; other site
859656011763	elongation factor G; Reviewed; Region: PRK00007
859656011764	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
859656011765	G1 box; other site
859656011766	putative GEF interaction site [polypeptide binding]; other site
859656011767	GTP/Mg2+ binding site [chemical binding]; other site
859656011768	Switch I region; other site
859656011769	G2 box; other site
859656011770	G3 box; other site
859656011771	Switch II region; other site
859656011772	G4 box; other site
859656011773	G5 box; other site
859656011774	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
859656011775	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
859656011776	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
859656011777	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
859656011778	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859656011779	ligand binding site [chemical binding]; other site
859656011780	flexible hinge region; other site
859656011781	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859656011782	putative switch regulator; other site
859656011783	non-specific DNA interactions [nucleotide binding]; other site
859656011784	DNA binding site [nucleotide binding]
859656011785	sequence specific DNA binding site [nucleotide binding]; other site
859656011786	putative cAMP binding site [chemical binding]; other site
859656011787	Predicted membrane protein [Function unknown]; Region: COG4539
859656011788	Ferredoxin [Energy production and conversion]; Region: COG1146
859656011789	4Fe-4S binding domain; Region: Fer4; pfam00037
859656011790	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
859656011791	Peptidase M30; Region: Peptidase_M30; pfam10460
859656011792	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
859656011793	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
859656011794	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
859656011795	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656011796	Walker A/P-loop; other site
859656011797	ATP binding site [chemical binding]; other site
859656011798	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
859656011799	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
859656011800	gamma subunit interface [polypeptide binding]; other site
859656011801	epsilon subunit interface [polypeptide binding]; other site
859656011802	LBP interface [polypeptide binding]; other site
859656011803	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
859656011804	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656011805	N-terminal plug; other site
859656011806	ligand-binding site [chemical binding]; other site
859656011807	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
859656011808	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656011809	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656011810	metal binding site [ion binding]; metal-binding site
859656011811	active site
859656011812	I-site; other site
859656011813	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656011814	malate:quinone oxidoreductase; Validated; Region: PRK05257
859656011815	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
859656011816	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656011817	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656011818	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
859656011819	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
859656011820	Protein export membrane protein; Region: SecD_SecF; cl14618
859656011821	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656011822	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656011823	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656011824	EamA-like transporter family; Region: EamA; pfam00892
859656011825	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859656011826	AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143
859656011827	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
859656011828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011829	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
859656011830	putative dimerization interface [polypeptide binding]; other site
859656011831	putative substrate binding pocket [chemical binding]; other site
859656011832	Predicted transcriptional regulator [Transcription]; Region: COG3905
859656011833	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
859656011834	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
859656011835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656011836	S-adenosylmethionine binding site [chemical binding]; other site
859656011837	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
859656011838	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859656011839	putative active site [active]
859656011840	catalytic residue [active]
859656011841	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
859656011842	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
859656011843	dimer interface [polypeptide binding]; other site
859656011844	NADP binding site [chemical binding]; other site
859656011845	catalytic residues [active]
859656011846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011847	D-galactonate transporter; Region: 2A0114; TIGR00893
859656011848	putative substrate translocation pore; other site
859656011849	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
859656011850	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
859656011851	active site
859656011852	tetramer interface [polypeptide binding]; other site
859656011853	galactarate dehydratase; Region: galactar-dH20; TIGR03248
859656011854	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
859656011855	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
859656011856	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859656011857	extended (e) SDRs; Region: SDR_e; cd08946
859656011858	NAD(P) binding site [chemical binding]; other site
859656011859	active site
859656011860	substrate binding site [chemical binding]; other site
859656011861	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
859656011862	Strictosidine synthase; Region: Str_synth; pfam03088
859656011863	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859656011864	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
859656011865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656011866	D-galactonate transporter; Region: 2A0114; TIGR00893
859656011867	putative substrate translocation pore; other site
859656011868	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
859656011869	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656011870	active site
859656011871	nucleotide binding site [chemical binding]; other site
859656011872	HIGH motif; other site
859656011873	KMSKS motif; other site
859656011874	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
859656011875	nudix motif; other site
859656011876	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
859656011877	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
859656011878	active site
859656011879	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656011880	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656011881	dimerization interface [polypeptide binding]; other site
859656011882	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656011883	dimer interface [polypeptide binding]; other site
859656011884	putative CheW interface [polypeptide binding]; other site
859656011885	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
859656011886	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656011887	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656011888	catalytic residue [active]
859656011889	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
859656011890	Predicted transcriptional regulators [Transcription]; Region: COG1733
859656011891	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
859656011892	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
859656011893	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
859656011894	NADP binding site [chemical binding]; other site
859656011895	RNA polymerase sigma factor; Provisional; Region: PRK11924
859656011896	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656011897	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656011898	DNA binding residues [nucleotide binding]
859656011899	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
859656011900	FecR protein; Region: FecR; pfam04773
859656011901	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656011902	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656011903	DNA binding residues [nucleotide binding]
859656011904	dimerization interface [polypeptide binding]; other site
859656011905	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656011906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656011907	active site
859656011908	phosphorylation site [posttranslational modification]
859656011909	intermolecular recognition site; other site
859656011910	dimerization interface [polypeptide binding]; other site
859656011911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656011912	DNA binding site [nucleotide binding]
859656011913	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
859656011914	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
859656011915	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
859656011916	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
859656011917	type III secretion protein HpaP; Region: HpaP; TIGR02557
859656011918	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
859656011919	FHIPEP family; Region: FHIPEP; pfam00771
859656011920	type III secretion system protein HrcU; Validated; Region: PRK09108
859656011921	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
859656011922	type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561
859656011923	type III secretion protein HrpB2; Region: HrpB2; TIGR02558
859656011924	Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669
859656011925	type III secretion protein HrpB4; Region: HrpB4; TIGR02560
859656011926	Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502
859656011927	type III secretion system protein HrpB; Validated; Region: PRK09098
859656011928	Flagellar assembly protein FliH; Region: FliH; pfam02108
859656011929	type III secretion system ATPase; Provisional; Region: PRK09099
859656011930	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
859656011931	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
859656011932	Walker A motif/ATP binding site; other site
859656011933	Walker B motif; other site
859656011934	Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720
859656011935	Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791
859656011936	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656011937	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656011938	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
859656011939	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656011940	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
859656011941	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656011942	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
859656011943	Leucine-rich repeats; other site
859656011944	Leucine rich repeat; Region: LRR_8; pfam13855
859656011945	Substrate binding site [chemical binding]; other site
859656011946	Leucine rich repeat; Region: LRR_8; pfam13855
859656011947	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
859656011948	Leucine rich repeat; Region: LRR_8; pfam13855
859656011949	SnoaL-like domain; Region: SnoaL_2; pfam12680
859656011950	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656011951	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656011952	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656011953	dimerization interface [polypeptide binding]; other site
859656011954	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
859656011955	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
859656011956	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
859656011957	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
859656011958	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
859656011959	active site
859656011960	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
859656011961	Interdomain contacts; other site
859656011962	Cytokine receptor motif; other site
859656011963	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
859656011964	SET domain; Region: SET; pfam00856
859656011965	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
859656011966	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
859656011967	glutamine synthetase, type I; Region: GlnA; TIGR00653
859656011968	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
859656011969	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
859656011970	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859656011971	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
859656011972	NAD binding site [chemical binding]; other site
859656011973	homodimer interface [polypeptide binding]; other site
859656011974	active site
859656011975	putative substrate binding site [chemical binding]; other site
859656011976	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
859656011977	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
859656011978	substrate-cofactor binding pocket; other site
859656011979	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656011980	catalytic residue [active]
859656011981	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656011982	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656011983	sequence-specific DNA binding site [nucleotide binding]; other site
859656011984	salt bridge; other site
859656011985	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
859656011986	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
859656011987	acyl-activating enzyme (AAE) consensus motif; other site
859656011988	AMP binding site [chemical binding]; other site
859656011989	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656011990	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
859656011991	NADPH bind site [chemical binding]; other site
859656011992	putative FMN binding site [chemical binding]; other site
859656011993	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
859656011994	putative FMN binding site [chemical binding]; other site
859656011995	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656011996	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656011997	active site
859656011998	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656011999	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012000	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
859656012001	active site
859656012002	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012003	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012004	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012005	putative NADP binding site [chemical binding]; other site
859656012006	active site
859656012007	Methyltransferase domain; Region: Methyltransf_31; pfam13847
859656012008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656012009	S-adenosylmethionine binding site [chemical binding]; other site
859656012010	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012011	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012012	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859656012013	active site
859656012014	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012015	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012016	putative NADP binding site [chemical binding]; other site
859656012017	KR domain; Region: KR; pfam08659
859656012018	active site
859656012019	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012020	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012021	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
859656012022	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012023	active site
859656012024	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012025	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012026	putative NADP binding site [chemical binding]; other site
859656012027	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012028	active site
859656012029	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859656012030	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859656012031	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012032	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012033	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012034	active site
859656012035	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012036	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012037	putative NADP binding site [chemical binding]; other site
859656012038	active site
859656012039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656012040	S-adenosylmethionine binding site [chemical binding]; other site
859656012041	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012042	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012043	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859656012044	active site
859656012045	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012046	putative NADP binding site [chemical binding]; other site
859656012047	KR domain; Region: KR; pfam08659
859656012048	active site
859656012049	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012050	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012051	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012052	active site
859656012053	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012054	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012055	putative NADP binding site [chemical binding]; other site
859656012056	active site
859656012057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656012058	S-adenosylmethionine binding site [chemical binding]; other site
859656012059	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012060	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656012062	S-adenosylmethionine binding site [chemical binding]; other site
859656012063	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012064	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012065	active site
859656012066	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012067	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012068	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012069	putative NADP binding site [chemical binding]; other site
859656012070	active site
859656012071	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012072	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
859656012073	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012074	active site
859656012075	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012076	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012077	putative NADP binding site [chemical binding]; other site
859656012078	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012079	active site
859656012080	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859656012081	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859656012082	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012083	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012084	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012085	active site
859656012086	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
859656012087	Cytochrome P450; Region: p450; cl12078
859656012088	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012089	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012090	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012091	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859656012092	active site
859656012093	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012094	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012095	putative NADP binding site [chemical binding]; other site
859656012096	active site
859656012097	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012098	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012099	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012100	active site
859656012101	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012102	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012103	KR domain; Region: KR; pfam08659
859656012104	putative NADP binding site [chemical binding]; other site
859656012105	active site
859656012106	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
859656012107	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012108	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012109	active site
859656012110	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012111	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012112	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012113	active site
859656012114	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
859656012115	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
859656012116	KR domain; Region: KR; pfam08659
859656012117	putative NADP binding site [chemical binding]; other site
859656012118	active site
859656012119	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012120	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012121	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012122	active site
859656012123	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012124	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
859656012125	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012126	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
859656012127	active site
859656012128	Condensation domain; Region: Condensation; pfam00668
859656012129	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656012130	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859656012131	Condensation domain; Region: Condensation; pfam00668
859656012132	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656012133	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859656012134	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
859656012135	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
859656012136	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859656012137	Predicted membrane protein [Function unknown]; Region: COG3174
859656012138	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
859656012139	FOG: CBS domain [General function prediction only]; Region: COG0517
859656012140	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
859656012141	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656012142	Ligand Binding Site [chemical binding]; other site
859656012143	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656012144	Ligand Binding Site [chemical binding]; other site
859656012145	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656012146	Ligand Binding Site [chemical binding]; other site
859656012147	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
859656012148	BON domain; Region: BON; pfam04972
859656012149	BON domain; Region: BON; pfam04972
859656012150	BON domain; Region: BON; pfam04972
859656012151	Flavodoxins [Energy production and conversion]; Region: FldA; COG0716
859656012152	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
859656012153	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
859656012154	BON domain; Region: BON; cl02771
859656012155	BON domain; Region: BON; pfam04972
859656012156	BON domain; Region: BON; pfam04972
859656012157	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859656012158	putative switch regulator; other site
859656012159	non-specific DNA interactions [nucleotide binding]; other site
859656012160	DNA binding site [nucleotide binding]
859656012161	sequence specific DNA binding site [nucleotide binding]; other site
859656012162	putative cAMP binding site [chemical binding]; other site
859656012163	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859656012164	ligand binding site [chemical binding]; other site
859656012165	PAS domain S-box; Region: sensory_box; TIGR00229
859656012166	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656012167	putative active site [active]
859656012168	heme pocket [chemical binding]; other site
859656012169	Histidine kinase; Region: HisKA_3; pfam07730
859656012170	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
859656012171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
859656012172	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656012173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656012174	active site
859656012175	phosphorylation site [posttranslational modification]
859656012176	intermolecular recognition site; other site
859656012177	dimerization interface [polypeptide binding]; other site
859656012178	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656012179	DNA binding residues [nucleotide binding]
859656012180	dimerization interface [polypeptide binding]; other site
859656012181	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
859656012182	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
859656012183	putative dimer interface [polypeptide binding]; other site
859656012184	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
859656012185	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
859656012186	Beta-Casp domain; Region: Beta-Casp; smart01027
859656012187	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
859656012188	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
859656012189	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
859656012190	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
859656012191	active site
859656012192	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859656012193	thymidine phosphorylase; Provisional; Region: PRK04350
859656012194	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
859656012195	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
859656012196	AAA domain; Region: AAA_33; pfam13671
859656012197	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
859656012198	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656012199	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656012200	trimer interface [polypeptide binding]; other site
859656012201	eyelet of channel; other site
859656012202	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
859656012203	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
859656012204	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
859656012205	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
859656012206	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
859656012207	ligand binding site [chemical binding]; other site
859656012208	homodimer interface [polypeptide binding]; other site
859656012209	NAD(P) binding site [chemical binding]; other site
859656012210	trimer interface B [polypeptide binding]; other site
859656012211	trimer interface A [polypeptide binding]; other site
859656012212	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
859656012213	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
859656012214	putative NAD(P) binding site [chemical binding]; other site
859656012215	catalytic Zn binding site [ion binding]; other site
859656012216	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
859656012217	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
859656012218	NADP binding site [chemical binding]; other site
859656012219	homodimer interface [polypeptide binding]; other site
859656012220	active site
859656012221	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
859656012222	ATP-binding site [chemical binding]; other site
859656012223	Gluconate-6-phosphate binding site [chemical binding]; other site
859656012224	AAA domain; Region: AAA_33; pfam13671
859656012225	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
859656012226	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
859656012227	dimerization interface [polypeptide binding]; other site
859656012228	ligand binding site [chemical binding]; other site
859656012229	NADP binding site [chemical binding]; other site
859656012230	catalytic site [active]
859656012231	hypothetical protein; Validated; Region: PRK06201
859656012232	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859656012233	aspartate aminotransferase; Provisional; Region: PRK06107
859656012234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656012235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656012236	homodimer interface [polypeptide binding]; other site
859656012237	catalytic residue [active]
859656012238	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
859656012239	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656012240	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
859656012241	putative dimerization interface [polypeptide binding]; other site
859656012242	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
859656012243	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
859656012244	carboxyltransferase (CT) interaction site; other site
859656012245	biotinylation site [posttranslational modification]; other site
859656012246	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
859656012247	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
859656012248	ATP-grasp domain; Region: ATP-grasp_4; cl17255
859656012249	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
859656012250	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
859656012251	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
859656012252	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
859656012253	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
859656012254	putative active site [active]
859656012255	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
859656012256	classical (c) SDRs; Region: SDR_c; cd05233
859656012257	NAD(P) binding site [chemical binding]; other site
859656012258	active site
859656012259	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656012260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656012261	dimer interface [polypeptide binding]; other site
859656012262	conserved gate region; other site
859656012263	putative PBP binding loops; other site
859656012264	ABC-ATPase subunit interface; other site
859656012265	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
859656012266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656012267	dimer interface [polypeptide binding]; other site
859656012268	conserved gate region; other site
859656012269	putative PBP binding loops; other site
859656012270	ABC-ATPase subunit interface; other site
859656012271	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
859656012272	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
859656012273	Walker A/P-loop; other site
859656012274	ATP binding site [chemical binding]; other site
859656012275	Q-loop/lid; other site
859656012276	ABC transporter signature motif; other site
859656012277	Walker B; other site
859656012278	D-loop; other site
859656012279	H-loop/switch region; other site
859656012280	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656012281	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656012282	substrate binding pocket [chemical binding]; other site
859656012283	membrane-bound complex binding site; other site
859656012284	hinge residues; other site
859656012285	BON domain; Region: BON; pfam04972
859656012286	FOG: CBS domain [General function prediction only]; Region: COG0517
859656012287	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
859656012288	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
859656012289	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
859656012290	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
859656012291	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
859656012292	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
859656012293	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
859656012294	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
859656012295	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
859656012296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
859656012297	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
859656012298	AAA domain; Region: AAA_33; pfam13671
859656012299	active site
859656012300	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
859656012301	CoA binding domain; Region: CoA_binding_2; pfam13380
859656012302	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
859656012303	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
859656012304	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
859656012305	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
859656012306	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656012307	DevC protein; Region: devC; TIGR01185
859656012308	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
859656012309	FtsX-like permease family; Region: FtsX; pfam02687
859656012310	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
859656012311	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859656012312	Walker A/P-loop; other site
859656012313	ATP binding site [chemical binding]; other site
859656012314	Q-loop/lid; other site
859656012315	ABC transporter signature motif; other site
859656012316	Walker B; other site
859656012317	D-loop; other site
859656012318	H-loop/switch region; other site
859656012319	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656012320	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
859656012321	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656012322	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
859656012323	putative FMN binding site [chemical binding]; other site
859656012324	NADPH bind site [chemical binding]; other site
859656012325	Evidence 7 : Gene remnant; Product type pe : putative enzyme
859656012326	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
859656012327	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
859656012328	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
859656012329	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
859656012330	catalytic loop [active]
859656012331	iron binding site [ion binding]; other site
859656012332	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
859656012333	[4Fe-4S] binding site [ion binding]; other site
859656012334	molybdopterin cofactor binding site; other site
859656012335	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
859656012336	molybdopterin cofactor binding site; other site
859656012337	Repair protein; Region: Repair_PSII; pfam04536
859656012338	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
859656012339	Repair protein; Region: Repair_PSII; pfam04536
859656012340	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
859656012341	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
859656012342	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
859656012343	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
859656012344	Chromate transporter; Region: Chromate_transp; pfam02417
859656012345	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
859656012346	30S subunit binding site; other site
859656012347	FtsH Extracellular; Region: FtsH_ext; pfam06480
859656012348	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
859656012349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656012350	Walker A motif; other site
859656012351	ATP binding site [chemical binding]; other site
859656012352	Walker B motif; other site
859656012353	arginine finger; other site
859656012354	Peptidase family M41; Region: Peptidase_M41; pfam01434
859656012355	ribonucleotide reductase-like protein; Provisional; Region: PRK06948
859656012356	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
859656012357	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
859656012358	active site
859656012359	dimer interface [polypeptide binding]; other site
859656012360	effector binding site; other site
859656012361	Cytochrome c553 [Energy production and conversion]; Region: COG2863
859656012362	Cytochrome c; Region: Cytochrom_C; cl11414
859656012363	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
859656012364	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
859656012365	putative substrate binding site [chemical binding]; other site
859656012366	putative ATP binding site [chemical binding]; other site
859656012367	Phage integrase protein; Region: DUF3701; pfam12482
859656012368	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
859656012369	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
859656012370	Int/Topo IB signature motif; other site
859656012371	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
859656012372	phosphate acetyltransferase; Provisional; Region: PRK11890
859656012373	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
859656012374	propionate/acetate kinase; Provisional; Region: PRK12379
859656012375	Acetokinase family; Region: Acetate_kinase; cl17229
859656012376	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
859656012377	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
859656012378	NAD binding site [chemical binding]; other site
859656012379	homotetramer interface [polypeptide binding]; other site
859656012380	homodimer interface [polypeptide binding]; other site
859656012381	substrate binding site [chemical binding]; other site
859656012382	active site
859656012383	hypothetical protein; Validated; Region: PRK09169
859656012384	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
859656012385	synthetase active site [active]
859656012386	NTP binding site [chemical binding]; other site
859656012387	metal binding site [ion binding]; metal-binding site
859656012388	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859656012389	metal binding triad [ion binding]; metal-binding site
859656012390	short chain dehydrogenase; Provisional; Region: PRK07063
859656012391	classical (c) SDRs; Region: SDR_c; cd05233
859656012392	NAD(P) binding site [chemical binding]; other site
859656012393	active site
859656012394	CAAX protease self-immunity; Region: Abi; pfam02517
859656012395	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
859656012396	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
859656012397	active site
859656012398	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
859656012399	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
859656012400	putative Cl- selectivity filter; other site
859656012401	putative pore gating glutamate residue; other site
859656012402	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
859656012403	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656012404	catalytic residues [active]
859656012405	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
859656012406	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
859656012407	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
859656012408	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859656012409	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859656012410	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
859656012411	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656012412	Walker A/P-loop; other site
859656012413	ATP binding site [chemical binding]; other site
859656012414	Q-loop/lid; other site
859656012415	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
859656012416	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
859656012417	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
859656012418	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
859656012419	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
859656012420	NAD(P) binding site [chemical binding]; other site
859656012421	homodimer interface [polypeptide binding]; other site
859656012422	substrate binding site [chemical binding]; other site
859656012423	active site
859656012424	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859656012425	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
859656012426	active site
859656012427	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
859656012428	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
859656012429	inhibitor-cofactor binding pocket; inhibition site
859656012430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656012431	catalytic residue [active]
859656012432	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
859656012433	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
859656012434	putative trimer interface [polypeptide binding]; other site
859656012435	putative CoA binding site [chemical binding]; other site
859656012436	Bacterial sugar transferase; Region: Bac_transf; pfam02397
859656012437	putative glycosyl transferase; Provisional; Region: PRK10307
859656012438	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
859656012439	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
859656012440	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
859656012441	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
859656012442	putative NAD(P) binding site [chemical binding]; other site
859656012443	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859656012444	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859656012445	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859656012446	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
859656012447	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
859656012448	trimer interface [polypeptide binding]; other site
859656012449	active site
859656012450	substrate binding site [chemical binding]; other site
859656012451	CoA binding site [chemical binding]; other site
859656012452	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
859656012453	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
859656012454	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
859656012455	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
859656012456	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859656012457	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
859656012458	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
859656012459	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
859656012460	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
859656012461	active site
859656012462	homodimer interface [polypeptide binding]; other site
859656012463	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
859656012464	Chain length determinant protein; Region: Wzz; pfam02706
859656012465	Chain length determinant protein; Region: Wzz; cl15801
859656012466	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
859656012467	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
859656012468	Nucleotide binding site [chemical binding]; other site
859656012469	P loop; other site
859656012470	DTAP/Switch II; other site
859656012471	Switch I; other site
859656012472	Low molecular weight phosphatase family; Region: LMWPc; cd00115
859656012473	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
859656012474	active site
859656012475	polysaccharide export protein Wza; Provisional; Region: PRK15078
859656012476	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
859656012477	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
859656012478	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656012479	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656012480	DNA binding site [nucleotide binding]
859656012481	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
859656012482	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859656012483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656012484	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
859656012485	Walker A/P-loop; other site
859656012486	ATP binding site [chemical binding]; other site
859656012487	Q-loop/lid; other site
859656012488	ABC transporter signature motif; other site
859656012489	Walker B; other site
859656012490	D-loop; other site
859656012491	H-loop/switch region; other site
859656012492	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859656012493	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
859656012494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656012495	Walker A/P-loop; other site
859656012496	ATP binding site [chemical binding]; other site
859656012497	Q-loop/lid; other site
859656012498	ABC transporter signature motif; other site
859656012499	Walker B; other site
859656012500	D-loop; other site
859656012501	H-loop/switch region; other site
859656012502	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
859656012503	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656012504	N-terminal plug; other site
859656012505	ligand-binding site [chemical binding]; other site
859656012506	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656012507	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656012508	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
859656012509	Condensation domain; Region: Condensation; pfam00668
859656012510	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656012511	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859656012512	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
859656012513	acyl-activating enzyme (AAE) consensus motif; other site
859656012514	AMP binding site [chemical binding]; other site
859656012515	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859656012516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
859656012517	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012518	Condensation domain; Region: Condensation; pfam00668
859656012519	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656012520	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859656012521	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
859656012522	muropeptide transporter; Validated; Region: ampG; cl17669
859656012523	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
859656012524	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
859656012525	active site
859656012526	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
859656012527	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
859656012528	Methyltransferase domain; Region: Methyltransf_12; pfam08242
859656012529	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
859656012530	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
859656012531	NADP binding site [chemical binding]; other site
859656012532	active site
859656012533	Condensation domain; Region: Condensation; pfam00668
859656012534	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
859656012535	Nonribosomal peptide synthase; Region: NRPS; pfam08415
859656012536	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859656012537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656012538	S-adenosylmethionine binding site [chemical binding]; other site
859656012539	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
859656012540	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
859656012541	thiazolinyl imide reductase; Region: thiaz-red; TIGR01761
859656012542	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859656012543	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
859656012544	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
859656012545	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
859656012546	acyl-activating enzyme (AAE) consensus motif; other site
859656012547	active site
859656012548	AMP binding site [chemical binding]; other site
859656012549	substrate binding site [chemical binding]; other site
859656012550	salicylate synthase; Region: salicyl_syn; TIGR03494
859656012551	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
859656012552	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
859656012553	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
859656012554	putative ligand binding site [chemical binding]; other site
859656012555	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656012556	HAMP domain; Region: HAMP; pfam00672
859656012557	dimerization interface [polypeptide binding]; other site
859656012558	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656012559	dimer interface [polypeptide binding]; other site
859656012560	putative CheW interface [polypeptide binding]; other site
859656012561	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
859656012562	Fatty acid desaturase; Region: FA_desaturase; pfam00487
859656012563	putative di-iron ligands [ion binding]; other site
859656012564	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
859656012565	succinic semialdehyde dehydrogenase; Region: PLN02278
859656012566	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859656012567	tetramerization interface [polypeptide binding]; other site
859656012568	NAD(P) binding site [chemical binding]; other site
859656012569	catalytic residues [active]
859656012570	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656012571	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656012572	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
859656012573	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656012574	Walker A/P-loop; other site
859656012575	ATP binding site [chemical binding]; other site
859656012576	Q-loop/lid; other site
859656012577	ABC transporter signature motif; other site
859656012578	Walker B; other site
859656012579	D-loop; other site
859656012580	H-loop/switch region; other site
859656012581	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
859656012582	Walker A/P-loop; other site
859656012583	ATP binding site [chemical binding]; other site
859656012584	Q-loop/lid; other site
859656012585	ABC transporter signature motif; other site
859656012586	Walker B; other site
859656012587	D-loop; other site
859656012588	H-loop/switch region; other site
859656012589	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
859656012590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656012591	dimer interface [polypeptide binding]; other site
859656012592	conserved gate region; other site
859656012593	ABC-ATPase subunit interface; other site
859656012594	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
859656012595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656012596	dimer interface [polypeptide binding]; other site
859656012597	conserved gate region; other site
859656012598	putative PBP binding loops; other site
859656012599	ABC-ATPase subunit interface; other site
859656012600	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
859656012601	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
859656012602	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859656012603	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859656012604	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
859656012605	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
859656012606	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656012607	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
859656012608	NAD(P) binding site [chemical binding]; other site
859656012609	catalytic residues [active]
859656012610	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
859656012611	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656012612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
859656012613	Coenzyme A binding pocket [chemical binding]; other site
859656012614	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
859656012615	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
859656012616	putative ligand binding site [chemical binding]; other site
859656012617	NAD binding site [chemical binding]; other site
859656012618	dimerization interface [polypeptide binding]; other site
859656012619	catalytic site [active]
859656012620	hypothetical protein; Provisional; Region: PRK05965
859656012621	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656012622	inhibitor-cofactor binding pocket; inhibition site
859656012623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656012624	catalytic residue [active]
859656012625	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656012626	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656012627	putative DNA binding site [nucleotide binding]; other site
859656012628	putative Zn2+ binding site [ion binding]; other site
859656012629	AsnC family; Region: AsnC_trans_reg; pfam01037
859656012630	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
859656012631	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
859656012632	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
859656012633	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859656012634	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
859656012635	Uncharacterized conserved protein [Function unknown]; Region: COG4104
859656012636	Protein of unknown function (DUF3274); Region: DUF3274; pfam11678
859656012637	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
859656012638	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656012639	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656012640	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
859656012641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
859656012642	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
859656012643	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
859656012644	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
859656012645	metal binding site [ion binding]; metal-binding site
859656012646	putative dimer interface [polypeptide binding]; other site
859656012647	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
859656012648	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
859656012649	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859656012650	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
859656012651	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859656012652	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
859656012653	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
859656012654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
859656012655	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
859656012656	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
859656012657	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
859656012658	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
859656012659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
859656012660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
859656012661	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
859656012662	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
859656012663	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859656012664	Predicted integral membrane protein [Function unknown]; Region: COG5572
859656012665	hypothetical protein; Provisional; Region: PRK05409
859656012666	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
859656012667	Predicted membrane protein [Function unknown]; Region: COG2259
859656012668	BON domain; Region: BON; pfam04972
859656012669	Outer membrane efflux protein; Region: OEP; pfam02321
859656012670	Outer membrane efflux protein; Region: OEP; pfam02321
859656012671	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656012672	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656012673	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656012674	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859656012675	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
859656012676	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656012677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656012678	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
859656012679	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
859656012680	putative molybdopterin cofactor binding site [chemical binding]; other site
859656012681	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
859656012682	putative molybdopterin cofactor binding site; other site
859656012683	Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526
859656012684	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656012685	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859656012686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656012687	putative active site [active]
859656012688	heme pocket [chemical binding]; other site
859656012689	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
859656012690	potassium uptake protein; Region: kup; TIGR00794
859656012691	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859656012692	DNA-binding site [nucleotide binding]; DNA binding site
859656012693	RNA-binding motif; other site
859656012694	Cold shock proteins [Transcription]; Region: CspC; COG1278
859656012695	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
859656012696	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
859656012697	tetrameric interface [polypeptide binding]; other site
859656012698	NAD binding site [chemical binding]; other site
859656012699	catalytic residues [active]
859656012700	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
859656012701	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656012702	inhibitor-cofactor binding pocket; inhibition site
859656012703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656012704	catalytic residue [active]
859656012705	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
859656012706	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656012707	DNA-binding site [nucleotide binding]; DNA binding site
859656012708	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656012709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656012710	homodimer interface [polypeptide binding]; other site
859656012711	catalytic residue [active]
859656012712	acetoacetate decarboxylase; Provisional; Region: PRK02265
859656012713	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
859656012714	classical (c) SDRs; Region: SDR_c; cd05233
859656012715	NAD(P) binding site [chemical binding]; other site
859656012716	active site
859656012717	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
859656012718	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
859656012719	nucleophile elbow; other site
859656012720	Patatin phospholipase; Region: DUF3734; pfam12536
859656012721	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
859656012722	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859656012723	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859656012724	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
859656012725	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
859656012726	N-terminal plug; other site
859656012727	ligand-binding site [chemical binding]; other site
859656012728	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
859656012729	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859656012730	putative substrate binding site [chemical binding]; other site
859656012731	putative ATP binding site [chemical binding]; other site
859656012732	Pathogenicity factor; Region: AvrE; pfam11725
859656012733	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
859656012734	HPr interaction site; other site
859656012735	glycerol kinase (GK) interaction site [polypeptide binding]; other site
859656012736	active site
859656012737	phosphorylation site [posttranslational modification]
859656012738	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
859656012739	dimerization domain swap beta strand [polypeptide binding]; other site
859656012740	regulatory protein interface [polypeptide binding]; other site
859656012741	active site
859656012742	regulatory phosphorylation site [posttranslational modification]; other site
859656012743	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
859656012744	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
859656012745	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
859656012746	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
859656012747	Maltoporin (phage lambda and maltose receptor) [Carbohydrate transport and metabolism]; Region: LamB; COG4580
859656012748	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
859656012749	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
859656012750	substrate binding [chemical binding]; other site
859656012751	active site
859656012752	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
859656012753	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
859656012754	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
859656012755	active site turn [active]
859656012756	phosphorylation site [posttranslational modification]
859656012757	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
859656012758	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859656012759	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656012760	DNA binding site [nucleotide binding]
859656012761	domain linker motif; other site
859656012762	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
859656012763	dimerization interface [polypeptide binding]; other site
859656012764	ligand binding site [chemical binding]; other site
859656012765	AsnC family; Region: AsnC_trans_reg; pfam01037
859656012766	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
859656012767	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656012768	NAD(P) binding site [chemical binding]; other site
859656012769	active site
859656012770	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
859656012771	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
859656012772	DNA binding residues [nucleotide binding]
859656012773	dimer interface [polypeptide binding]; other site
859656012774	metal binding site [ion binding]; metal-binding site
859656012775	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
859656012776	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
859656012777	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656012778	MULE transposase domain; Region: MULE; pfam10551
859656012779	Xylella fastidiosa protein of unknown function (DUF769); Region: DUF769; pfam05590
859656012780	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
859656012781	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
859656012782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792
859656012783	haemagglutination activity domain; Region: Haemagg_act; pfam05860
859656012784	adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731
859656012785	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
859656012786	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
859656012787	RTX toxin acyltransferase family; Region: HlyC; cl01131
859656012788	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859656012789	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859656012790	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
859656012791	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
859656012792	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
859656012793	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
859656012794	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
859656012795	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
859656012796	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
859656012797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656012798	Walker A motif; other site
859656012799	ATP binding site [chemical binding]; other site
859656012800	Walker B motif; other site
859656012801	arginine finger; other site
859656012802	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656012803	Predicted membrane protein [Function unknown]; Region: COG4655
859656012804	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
859656012805	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
859656012806	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
859656012807	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656012808	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
859656012809	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
859656012810	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
859656012811	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
859656012812	ATP binding site [chemical binding]; other site
859656012813	Walker A motif; other site
859656012814	hexamer interface [polypeptide binding]; other site
859656012815	Walker B motif; other site
859656012816	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
859656012817	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
859656012818	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
859656012819	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
859656012820	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
859656012821	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
859656012822	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
859656012823	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
859656012824	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
859656012825	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
859656012826	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656012827	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656012828	DNA binding residues [nucleotide binding]
859656012829	dimerization interface [polypeptide binding]; other site
859656012830	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656012831	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656012832	metal binding site [ion binding]; metal-binding site
859656012833	active site
859656012834	I-site; other site
859656012835	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656012836	H-NS histone family; Region: Histone_HNS; pfam00816
859656012837	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
859656012838	Cache domain; Region: Cache_2; pfam08269
859656012839	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656012840	dimer interface [polypeptide binding]; other site
859656012841	putative CheW interface [polypeptide binding]; other site
859656012842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656012843	PAS fold; Region: PAS_3; pfam08447
859656012844	putative active site [active]
859656012845	heme pocket [chemical binding]; other site
859656012846	UDP-glucose 4-epimerase; Region: PLN02240
859656012847	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
859656012848	NAD binding site [chemical binding]; other site
859656012849	homodimer interface [polypeptide binding]; other site
859656012850	active site
859656012851	substrate binding site [chemical binding]; other site
859656012852	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
859656012853	active site
859656012854	Int/Topo IB signature motif; other site
859656012855	catalytic residues [active]
859656012856	DNA binding site [nucleotide binding]
859656012857	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
859656012858	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
859656012859	active site
859656012860	motif I; other site
859656012861	motif II; other site
859656012862	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
859656012863	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
859656012864	active site
859656012865	homotetramer interface [polypeptide binding]; other site
859656012866	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656012867	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656012868	putative DNA binding site [nucleotide binding]; other site
859656012869	putative Zn2+ binding site [ion binding]; other site
859656012870	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
859656012871	Evidence 7 : Gene remnant
859656012872	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
859656012873	Uncharacterized conserved protein [Function unknown]; Region: COG1656
859656012874	Protein of unknown function DUF82; Region: DUF82; pfam01927
859656012875	Transglycosylase SLT domain; Region: SLT_2; pfam13406
859656012876	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
859656012877	N-acetyl-D-glucosamine binding site [chemical binding]; other site
859656012878	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
859656012879	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656012880	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656012881	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
859656012882	putative effector binding pocket; other site
859656012883	putative dimerization interface [polypeptide binding]; other site
859656012884	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
859656012885	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
859656012886	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656012887	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656012888	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656012889	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656012890	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859656012891	Lysine efflux permease [General function prediction only]; Region: COG1279
859656012892	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
859656012893	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656012894	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656012895	dimerization interface [polypeptide binding]; other site
859656012896	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
859656012897	Asn-Pro-Ala signature motifs; other site
859656012898	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
859656012899	Low molecular weight phosphatase family; Region: LMWPc; cd00115
859656012900	active site
859656012901	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
859656012902	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656012903	putative metal binding site [ion binding]; other site
859656012904	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656012905	dimerization interface [polypeptide binding]; other site
859656012906	putative DNA binding site [nucleotide binding]; other site
859656012907	putative Zn2+ binding site [ion binding]; other site
859656012908	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
859656012909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656012910	binding surface
859656012911	TPR motif; other site
859656012912	Tetratricopeptide repeat; Region: TPR_12; pfam13424
859656012913	PAAR motif; Region: PAAR_motif; pfam05488
859656012914	RHS Repeat; Region: RHS_repeat; pfam05593
859656012915	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656012916	RHS Repeat; Region: RHS_repeat; pfam05593
859656012917	RHS Repeat; Region: RHS_repeat; cl11982
859656012918	RHS Repeat; Region: RHS_repeat; pfam05593
859656012919	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
859656012920	RHS Repeat; Region: RHS_repeat; pfam05593
859656012921	RHS Repeat; Region: RHS_repeat; pfam05593
859656012922	RHS Repeat; Region: RHS_repeat; pfam05593
859656012923	RHS Repeat; Region: RHS_repeat; cl11982
859656012924	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656012925	Uncharacterized conserved protein [Function unknown]; Region: COG5435
859656012926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656012927	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656012928	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656012929	hypothetical protein; Provisional; Region: PRK09946
859656012930	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
859656012931	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656012932	substrate binding pocket [chemical binding]; other site
859656012933	membrane-bound complex binding site; other site
859656012934	hinge residues; other site
859656012935	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656012936	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656012937	DNA binding residues [nucleotide binding]
859656012938	dimerization interface [polypeptide binding]; other site
859656012939	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656012940	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656012941	DNA binding residues [nucleotide binding]
859656012942	dimerization interface [polypeptide binding]; other site
859656012943	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
859656012944	glutaminase; Provisional; Region: PRK00971
859656012945	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
859656012946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656012947	putative PBP binding loops; other site
859656012948	dimer interface [polypeptide binding]; other site
859656012949	ABC-ATPase subunit interface; other site
859656012950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656012951	Walker A/P-loop; other site
859656012952	ATP binding site [chemical binding]; other site
859656012953	ABC transporter; Region: ABC_tran; pfam00005
859656012954	Q-loop/lid; other site
859656012955	ABC transporter signature motif; other site
859656012956	Walker B; other site
859656012957	D-loop; other site
859656012958	H-loop/switch region; other site
859656012959	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
859656012960	molybdenum-pterin binding domain; Region: Mop; TIGR00638
859656012961	PAS domain S-box; Region: sensory_box; TIGR00229
859656012962	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
859656012963	PAS domain S-box; Region: sensory_box; TIGR00229
859656012964	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656012965	putative active site [active]
859656012966	heme pocket [chemical binding]; other site
859656012967	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656012968	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656012969	metal binding site [ion binding]; metal-binding site
859656012970	active site
859656012971	I-site; other site
859656012972	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656012973	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656012974	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656012975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
859656012976	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
859656012977	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656012978	Ligand Binding Site [chemical binding]; other site
859656012979	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
859656012980	dimer interface [polypeptide binding]; other site
859656012981	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
859656012982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656012983	active site
859656012984	phosphorylation site [posttranslational modification]
859656012985	intermolecular recognition site; other site
859656012986	dimerization interface [polypeptide binding]; other site
859656012987	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656012988	DNA binding site [nucleotide binding]
859656012989	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656012990	dimerization interface [polypeptide binding]; other site
859656012991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656012992	dimer interface [polypeptide binding]; other site
859656012993	phosphorylation site [posttranslational modification]
859656012994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656012995	ATP binding site [chemical binding]; other site
859656012996	Mg2+ binding site [ion binding]; other site
859656012997	G-X-G motif; other site
859656012998	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
859656012999	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
859656013000	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
859656013001	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
859656013002	Transporter associated domain; Region: CorC_HlyC; pfam03471
859656013003	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
859656013004	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
859656013005	LGFP repeat; Region: LGFP; pfam08310
859656013006	LGFP repeat; Region: LGFP; pfam08310
859656013007	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
859656013008	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
859656013009	Dodecin; Region: Dodecin; pfam07311
859656013010	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
859656013011	H+ Antiporter protein; Region: 2A0121; TIGR00900
859656013012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013013	putative substrate translocation pore; other site
859656013014	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
859656013015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656013016	putative active site [active]
859656013017	heme pocket [chemical binding]; other site
859656013018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656013019	dimer interface [polypeptide binding]; other site
859656013020	phosphorylation site [posttranslational modification]
859656013021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013022	ATP binding site [chemical binding]; other site
859656013023	Mg2+ binding site [ion binding]; other site
859656013024	G-X-G motif; other site
859656013025	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656013026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013027	active site
859656013028	phosphorylation site [posttranslational modification]
859656013029	intermolecular recognition site; other site
859656013030	dimerization interface [polypeptide binding]; other site
859656013031	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
859656013032	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
859656013033	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
859656013034	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
859656013035	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
859656013036	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
859656013037	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
859656013038	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
859656013039	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
859656013040	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
859656013041	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
859656013042	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859656013043	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
859656013044	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
859656013045	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
859656013046	Walker A/P-loop; other site
859656013047	ATP binding site [chemical binding]; other site
859656013048	Q-loop/lid; other site
859656013049	ABC transporter signature motif; other site
859656013050	Walker B; other site
859656013051	D-loop; other site
859656013052	H-loop/switch region; other site
859656013053	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
859656013054	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656013055	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656013056	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
859656013057	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
859656013058	substrate binding site [chemical binding]; other site
859656013059	ATP binding site [chemical binding]; other site
859656013060	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
859656013061	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
859656013062	dimer interface [polypeptide binding]; other site
859656013063	active site
859656013064	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
859656013065	substrate binding site [chemical binding]; other site
859656013066	catalytic residue [active]
859656013067	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859656013068	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859656013069	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859656013070	putative active site [active]
859656013071	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
859656013072	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
859656013073	active site
859656013074	putative substrate binding pocket [chemical binding]; other site
859656013075	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
859656013076	D-aminoacylase, C-terminal region; Region: D-aminoacyl_C; pfam07908
859656013077	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859656013078	homotrimer interaction site [polypeptide binding]; other site
859656013079	putative active site [active]
859656013080	GntP family permease; Region: GntP_permease; pfam02447
859656013081	fructuronate transporter; Provisional; Region: PRK10034; cl15264
859656013082	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
859656013083	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
859656013084	active site
859656013085	intersubunit interface [polypeptide binding]; other site
859656013086	catalytic residue [active]
859656013087	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
859656013088	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
859656013089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656013090	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656013091	DNA binding residues [nucleotide binding]
859656013092	dimerization interface [polypeptide binding]; other site
859656013093	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
859656013094	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
859656013095	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656013096	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656013097	dimerization interface [polypeptide binding]; other site
859656013098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656013099	dimer interface [polypeptide binding]; other site
859656013100	phosphorylation site [posttranslational modification]
859656013101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013102	ATP binding site [chemical binding]; other site
859656013103	Mg2+ binding site [ion binding]; other site
859656013104	G-X-G motif; other site
859656013105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656013106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013107	active site
859656013108	phosphorylation site [posttranslational modification]
859656013109	intermolecular recognition site; other site
859656013110	dimerization interface [polypeptide binding]; other site
859656013111	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656013112	DNA binding site [nucleotide binding]
859656013113	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656013114	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656013115	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656013116	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
859656013117	Protein export membrane protein; Region: SecD_SecF; cl14618
859656013118	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
859656013119	Protein export membrane protein; Region: SecD_SecF; cl14618
859656013120	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656013121	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
859656013122	PAS domain S-box; Region: sensory_box; TIGR00229
859656013123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656013124	putative active site [active]
859656013125	heme pocket [chemical binding]; other site
859656013126	PAS fold; Region: PAS_3; pfam08447
859656013127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656013128	putative active site [active]
859656013129	heme pocket [chemical binding]; other site
859656013130	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656013131	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656013132	metal binding site [ion binding]; metal-binding site
859656013133	active site
859656013134	I-site; other site
859656013135	Flagellar protein YcgR; Region: YcgR_2; pfam12945
859656013136	PilZ domain; Region: PilZ; pfam07238
859656013137	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
859656013138	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
859656013139	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
859656013140	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656013141	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656013142	metal binding site [ion binding]; metal-binding site
859656013143	active site
859656013144	I-site; other site
859656013145	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
859656013146	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
859656013147	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656013148	dimerization interface [polypeptide binding]; other site
859656013149	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656013150	dimer interface [polypeptide binding]; other site
859656013151	putative CheW interface [polypeptide binding]; other site
859656013152	Predicted small secreted protein [Function unknown]; Region: COG5510
859656013153	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
859656013154	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
859656013155	putative active site [active]
859656013156	catalytic site [active]
859656013157	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
859656013158	PLD-like domain; Region: PLDc_2; pfam13091
859656013159	putative active site [active]
859656013160	catalytic site [active]
859656013161	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
859656013162	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656013163	putative active site [active]
859656013164	catalytic site [active]
859656013165	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
859656013166	putative active site [active]
859656013167	catalytic site [active]
859656013168	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
859656013169	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
859656013170	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
859656013171	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
859656013172	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656013173	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656013174	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656013175	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656013176	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656013177	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656013178	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
859656013179	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
859656013180	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
859656013181	[4Fe-4S] binding site [ion binding]; other site
859656013182	molybdopterin cofactor binding site; other site
859656013183	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
859656013184	molybdopterin cofactor binding site; other site
859656013185	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
859656013186	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
859656013187	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
859656013188	nitrite reductase subunit NirD; Provisional; Region: PRK14989
859656013189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656013190	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
859656013191	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
859656013192	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
859656013193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013194	putative substrate translocation pore; other site
859656013195	PAS domain; Region: PAS_9; pfam13426
859656013196	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656013197	putative active site [active]
859656013198	heme pocket [chemical binding]; other site
859656013199	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
859656013200	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656013201	dimer interface [polypeptide binding]; other site
859656013202	putative CheW interface [polypeptide binding]; other site
859656013203	Isopentenyl transferase; Region: IPT; pfam01745
859656013204	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
859656013205	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
859656013206	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
859656013207	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656013208	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
859656013209	active site
859656013210	catalytic site [active]
859656013211	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
859656013212	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
859656013213	PIN domain; Region: PIN_3; pfam13470
859656013214	Helix-turn-helix domain; Region: HTH_17; cl17695
859656013215	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
859656013216	dimer interface [polypeptide binding]; other site
859656013217	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656013218	metal binding site [ion binding]; metal-binding site
859656013219	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859656013220	aspartate aminotransferase; Provisional; Region: PRK05764
859656013221	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656013222	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656013223	homodimer interface [polypeptide binding]; other site
859656013224	catalytic residue [active]
859656013225	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859656013226	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
859656013227	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
859656013228	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013229	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
859656013230	dimerization interface [polypeptide binding]; other site
859656013231	substrate binding pocket [chemical binding]; other site
859656013232	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656013233	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
859656013234	dimerization interface [polypeptide binding]; other site
859656013235	active site
859656013236	DoxX-like family; Region: DoxX_2; pfam13564
859656013237	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656013238	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656013239	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
859656013240	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
859656013241	inhibitor site; inhibition site
859656013242	active site
859656013243	dimer interface [polypeptide binding]; other site
859656013244	catalytic residue [active]
859656013245	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
859656013246	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
859656013247	putative active site [active]
859656013248	metal binding site [ion binding]; metal-binding site
859656013249	Protein of unknown function, DUF1537; Region: DUF1537; pfam07005
859656013250	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
859656013251	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
859656013252	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
859656013253	Na binding site [ion binding]; other site
859656013254	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
859656013255	BNR repeat-like domain; Region: BNR_2; pfam13088
859656013256	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
859656013257	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
859656013258	short chain dehydrogenase; Provisional; Region: PRK07577
859656013259	classical (c) SDRs; Region: SDR_c; cd05233
859656013260	NAD(P) binding site [chemical binding]; other site
859656013261	active site
859656013262	Predicted dehydrogenase [General function prediction only]; Region: COG5322
859656013263	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
859656013264	NAD(P) binding pocket [chemical binding]; other site
859656013265	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
859656013266	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
859656013267	inhibitor-cofactor binding pocket; inhibition site
859656013268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656013269	catalytic residue [active]
859656013270	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
859656013271	Predicted transcriptional regulators [Transcription]; Region: COG1510
859656013272	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656013273	dimerization interface [polypeptide binding]; other site
859656013274	putative DNA binding site [nucleotide binding]; other site
859656013275	putative Zn2+ binding site [ion binding]; other site
859656013276	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
859656013277	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
859656013278	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
859656013279	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
859656013280	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
859656013281	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
859656013282	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
859656013283	active site
859656013284	catalytic triad [active]
859656013285	oxyanion hole [active]
859656013286	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859656013287	homotrimer interaction site [polypeptide binding]; other site
859656013288	putative active site [active]
859656013289	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859656013290	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
859656013291	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
859656013292	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
859656013293	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
859656013294	active site
859656013295	metal binding site [ion binding]; metal-binding site
859656013296	PGDYG protein; Region: PGDYG; pfam14083
859656013297	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
859656013298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656013299	non-specific DNA binding site [nucleotide binding]; other site
859656013300	salt bridge; other site
859656013301	sequence-specific DNA binding site [nucleotide binding]; other site
859656013302	HipA N-terminal domain; Region: Couple_hipA; pfam13657
859656013303	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
859656013304	HipA-like N-terminal domain; Region: HipA_N; pfam07805
859656013305	HipA-like C-terminal domain; Region: HipA_C; pfam07804
859656013306	Evidence 4 : Homologs of previously reported genes of unknown function
859656013307	Evidence 4 : Homologs of previously reported genes of unknown function
859656013308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013309	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656013310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013311	LysR family transcriptional regulator; Provisional; Region: PRK14997
859656013312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013313	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
859656013314	putative effector binding pocket; other site
859656013315	putative dimerization interface [polypeptide binding]; other site
859656013316	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
859656013317	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656013318	Evidence 4 : Homologs of previously reported genes of unknown function
859656013319	Beta-lactamase; Region: Beta-lactamase; cl17358
859656013320	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859656013321	L-aspartate oxidase; Provisional; Region: PRK06175
859656013322	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
859656013323	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
859656013324	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859656013325	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
859656013326	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
859656013327	active site
859656013328	acyl-activating enzyme (AAE) consensus motif; other site
859656013329	putative CoA binding site [chemical binding]; other site
859656013330	AMP binding site [chemical binding]; other site
859656013331	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656013332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013333	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
859656013334	putative dimerization interface [polypeptide binding]; other site
859656013335	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
859656013336	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859656013337	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
859656013338	BNR repeat-like domain; Region: BNR_2; pfam13088
859656013339	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
859656013340	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter
859656013341	Archaeal ATPase; Region: Arch_ATPase; pfam01637
859656013342	Conserved TM helix; Region: TM_helix; pfam05552
859656013343	Conserved TM helix; Region: TM_helix; pfam05552
859656013344	hypothetical protein; Provisional; Region: PRK02237
859656013345	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
859656013346	Family description; Region: UvrD_C_2; pfam13538
859656013347	putative transporter; Provisional; Region: PRK10504
859656013348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013349	putative substrate translocation pore; other site
859656013350	fumarate hydratase; Reviewed; Region: fumC; PRK00485
859656013351	Class II fumarases; Region: Fumarase_classII; cd01362
859656013352	active site
859656013353	tetramer interface [polypeptide binding]; other site
859656013354	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
859656013355	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
859656013356	legume lectins; Region: lectin_L-type; cl14058
859656013357	carbohydrate binding site [chemical binding]; other site
859656013358	metal binding site [ion binding]; metal-binding site
859656013359	homotetramer interaction site [polypeptide binding]; other site
859656013360	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
859656013361	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
859656013362	PilX N-terminal; Region: PilX_N; pfam14341
859656013363	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
859656013364	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
859656013365	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
859656013366	Type II transport protein GspH; Region: GspH; pfam12019
859656013367	S-adenosylmethionine decarboxylase [Amino acid transport and metabolism]; Region: SpeD; COG1586
859656013368	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
859656013369	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
859656013370	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
859656013371	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
859656013372	Short C-terminal domain; Region: SHOCT; pfam09851
859656013373	Predicted membrane protein [Function unknown]; Region: COG3766
859656013374	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
859656013375	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
859656013376	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
859656013377	putative ligand binding site [chemical binding]; other site
859656013378	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
859656013379	TM-ABC transporter signature motif; other site
859656013380	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
859656013381	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
859656013382	TM-ABC transporter signature motif; other site
859656013383	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
859656013384	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
859656013385	Walker A/P-loop; other site
859656013386	ATP binding site [chemical binding]; other site
859656013387	Q-loop/lid; other site
859656013388	ABC transporter signature motif; other site
859656013389	Walker B; other site
859656013390	D-loop; other site
859656013391	H-loop/switch region; other site
859656013392	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
859656013393	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
859656013394	Walker A/P-loop; other site
859656013395	ATP binding site [chemical binding]; other site
859656013396	Q-loop/lid; other site
859656013397	ABC transporter signature motif; other site
859656013398	Walker B; other site
859656013399	D-loop; other site
859656013400	H-loop/switch region; other site
859656013401	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
859656013402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656013403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
859656013404	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
859656013405	Predicted membrane protein [Function unknown]; Region: COG3759
859656013406	hypothetical protein; Validated; Region: PRK09169
859656013407	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
859656013408	metal binding triad [ion binding]; metal-binding site
859656013409	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
859656013410	mercuric reductase; Validated; Region: PRK06370
859656013411	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
859656013412	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
859656013413	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
859656013414	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
859656013415	PhnA protein; Region: PhnA; pfam03831
859656013416	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
859656013417	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
859656013418	NodB motif; other site
859656013419	putative active site [active]
859656013420	putative catalytic site [active]
859656013421	putative Zn binding site [ion binding]; other site
859656013422	YGGT family; Region: YGGT; pfam02325
859656013423	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5544
859656013424	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
859656013425	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
859656013426	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
859656013427	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
859656013428	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
859656013429	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
859656013430	DNA binding residues [nucleotide binding]
859656013431	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
859656013432	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
859656013433	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
859656013434	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
859656013435	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
859656013436	FHIPEP family; Region: FHIPEP; pfam00771
859656013437	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
859656013438	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
859656013439	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656013440	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656013441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013442	Major Facilitator Superfamily; Region: MFS_1; pfam07690
859656013443	putative substrate translocation pore; other site
859656013444	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
859656013445	Dehydroquinase class II; Region: DHquinase_II; pfam01220
859656013446	active site
859656013447	trimer interface [polypeptide binding]; other site
859656013448	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
859656013449	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
859656013450	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
859656013451	shikimate binding site; other site
859656013452	NAD(P) binding site [chemical binding]; other site
859656013453	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
859656013454	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
859656013455	trimer interface [polypeptide binding]; other site
859656013456	eyelet of channel; other site
859656013457	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
859656013458	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
859656013459	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
859656013460	dimer interface [polypeptide binding]; other site
859656013461	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
859656013462	active site
859656013463	Fe binding site [ion binding]; other site
859656013464	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859656013465	YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849
859656013466	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
859656013467	chemotaxis regulator CheZ; Provisional; Region: PRK11166
859656013468	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
859656013469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013470	active site
859656013471	phosphorylation site [posttranslational modification]
859656013472	intermolecular recognition site; other site
859656013473	dimerization interface [polypeptide binding]; other site
859656013474	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
859656013475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013476	active site
859656013477	phosphorylation site [posttranslational modification]
859656013478	intermolecular recognition site; other site
859656013479	dimerization interface [polypeptide binding]; other site
859656013480	CheB methylesterase; Region: CheB_methylest; pfam01339
859656013481	CheD chemotactic sensory transduction; Region: CheD; cl00810
859656013482	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
859656013483	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
859656013484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656013485	Evidence 4 : Homologs of previously reported genes of unknown function
859656013486	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
859656013487	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
859656013488	dimer interface [polypeptide binding]; other site
859656013489	ligand binding site [chemical binding]; other site
859656013490	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656013491	dimerization interface [polypeptide binding]; other site
859656013492	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
859656013493	dimer interface [polypeptide binding]; other site
859656013494	putative CheW interface [polypeptide binding]; other site
859656013495	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
859656013496	putative CheA interaction surface; other site
859656013497	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
859656013498	putative binding surface; other site
859656013499	active site
859656013500	CheY binding; Region: CheY-binding; pfam09078
859656013501	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
859656013502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013503	ATP binding site [chemical binding]; other site
859656013504	Mg2+ binding site [ion binding]; other site
859656013505	G-X-G motif; other site
859656013506	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
859656013507	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656013508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013509	active site
859656013510	phosphorylation site [posttranslational modification]
859656013511	intermolecular recognition site; other site
859656013512	dimerization interface [polypeptide binding]; other site
859656013513	flagellar motor protein MotB; Validated; Region: motB; PRK09041
859656013514	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
859656013515	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859656013516	ligand binding site [chemical binding]; other site
859656013517	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
859656013518	flagellar motor protein MotA; Validated; Region: PRK09110
859656013519	transcriptional activator FlhC; Provisional; Region: PRK12722
859656013520	transcriptional activator FlhD; Provisional; Region: PRK02909
859656013521	Predicted periplasmic protein [Function unknown]; Region: COG3904
859656013522	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656013523	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
859656013524	putative ligand binding site [chemical binding]; other site
859656013525	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
859656013526	CoA-transferase family III; Region: CoA_transf_3; pfam02515
859656013527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656013528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656013529	dimer interface [polypeptide binding]; other site
859656013530	phosphorylation site [posttranslational modification]
859656013531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013532	ATP binding site [chemical binding]; other site
859656013533	Mg2+ binding site [ion binding]; other site
859656013534	G-X-G motif; other site
859656013535	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656013536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013537	active site
859656013538	phosphorylation site [posttranslational modification]
859656013539	intermolecular recognition site; other site
859656013540	dimerization interface [polypeptide binding]; other site
859656013541	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656013542	DNA binding site [nucleotide binding]
859656013543	Uncharacterized protein conserved in bacteria with a cystatin-like fold [Function unknown]; Region: COG4875
859656013544	SnoaL-like domain; Region: SnoaL_3; pfam13474
859656013545	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
859656013546	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656013547	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
859656013548	active site
859656013549	Mn binding site [ion binding]; other site
859656013550	Cytochrome c [Energy production and conversion]; Region: COG3258
859656013551	Cytochrome c; Region: Cytochrom_C; cl11414
859656013552	Cytochrome c; Region: Cytochrom_C; pfam00034
859656013553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656013554	HAMP domain; Region: HAMP; pfam00672
859656013555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656013556	dimer interface [polypeptide binding]; other site
859656013557	phosphorylation site [posttranslational modification]
859656013558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013559	ATP binding site [chemical binding]; other site
859656013560	Mg2+ binding site [ion binding]; other site
859656013561	G-X-G motif; other site
859656013562	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656013563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013564	active site
859656013565	phosphorylation site [posttranslational modification]
859656013566	intermolecular recognition site; other site
859656013567	dimerization interface [polypeptide binding]; other site
859656013568	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656013569	DNA binding site [nucleotide binding]
859656013570	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656013571	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656013572	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656013573	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656013574	Protein export membrane protein; Region: SecD_SecF; cl14618
859656013575	tyramine oxidase; Provisional; Region: tynA; PRK14696
859656013576	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
859656013577	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
859656013578	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
859656013579	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
859656013580	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
859656013581	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
859656013582	active site
859656013583	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
859656013584	active site
859656013585	tetramer interface [polypeptide binding]; other site
859656013586	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656013587	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656013588	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
859656013589	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
859656013590	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
859656013591	amidase catalytic site [active]
859656013592	Zn binding residues [ion binding]; other site
859656013593	substrate binding site [chemical binding]; other site
859656013594	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
859656013595	Outer membrane efflux protein; Region: OEP; pfam02321
859656013596	Outer membrane efflux protein; Region: OEP; pfam02321
859656013597	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656013598	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656013599	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656013600	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
859656013601	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
859656013602	Walker A/P-loop; other site
859656013603	ATP binding site [chemical binding]; other site
859656013604	Q-loop/lid; other site
859656013605	ABC transporter signature motif; other site
859656013606	Walker B; other site
859656013607	D-loop; other site
859656013608	H-loop/switch region; other site
859656013609	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
859656013610	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
859656013611	FtsX-like permease family; Region: FtsX; pfam02687
859656013612	Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313
859656013613	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656013614	Evidence 4 : Homologs of previously reported genes of unknown function
859656013615	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
859656013616	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
859656013617	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
859656013618	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
859656013619	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859656013620	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
859656013621	Evidence 4 : Homologs of previously reported genes of unknown function
859656013622	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11136451, 9696756
859656013623	Evidence 4 : Homologs of previously reported genes of unknown function
859656013624	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
859656013625	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
859656013626	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
859656013627	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
859656013628	DNA binding residues [nucleotide binding]
859656013629	dimerization interface [polypeptide binding]; other site
859656013630	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656013631	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013632	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
859656013633	putative effector binding pocket; other site
859656013634	putative dimerization interface [polypeptide binding]; other site
859656013635	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
859656013636	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
859656013637	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
859656013638	active site
859656013639	catalytic tetrad [active]
859656013640	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
859656013641	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
859656013642	putative NAD(P) binding site [chemical binding]; other site
859656013643	putative substrate binding site [chemical binding]; other site
859656013644	catalytic Zn binding site [ion binding]; other site
859656013645	structural Zn binding site [ion binding]; other site
859656013646	dimer interface [polypeptide binding]; other site
859656013647	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
859656013648	active site
859656013649	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
859656013650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
859656013651	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
859656013652	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
859656013653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013654	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
859656013655	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
859656013656	HlyD family secretion protein; Region: HlyD; pfam00529
859656013657	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656013658	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
859656013659	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
859656013660	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859656013661	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
859656013662	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656013663	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
859656013664	AAA domain; Region: AAA_21; pfam13304
859656013665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
859656013666	AAA domain; Region: AAA_21; pfam13304
859656013667	Walker A/P-loop; other site
859656013668	ATP binding site [chemical binding]; other site
859656013669	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
859656013670	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
859656013671	Evidence 4 : Homologs of previously reported genes of unknown function
859656013672	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656013673	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013674	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
859656013675	putative effector binding pocket; other site
859656013676	putative dimerization interface [polypeptide binding]; other site
859656013677	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
859656013678	tartrate dehydrogenase; Region: TTC; TIGR02089
859656013679	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
859656013680	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
859656013681	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
859656013682	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
859656013683	MOFRL family; Region: MOFRL; pfam05161
859656013684	pyruvate kinase; Provisional; Region: PRK06247
859656013685	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
859656013686	domain interfaces; other site
859656013687	active site
859656013688	Uncharacterized conserved protein [Function unknown]; Region: COG5649
859656013689	single-stranded binding protein UL29; Provisional; Region: PHA03362
859656013690	Uncharacterized conserved protein [Function unknown]; Region: COG1262
859656013691	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
859656013692	PAAR motif; Region: PAAR_motif; pfam05488
859656013693	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
859656013694	RHS Repeat; Region: RHS_repeat; pfam05593
859656013695	RHS Repeat; Region: RHS_repeat; pfam05593
859656013696	RHS Repeat; Region: RHS_repeat; pfam05593
859656013697	RHS Repeat; Region: RHS_repeat; pfam05593
859656013698	RHS Repeat; Region: RHS_repeat; pfam05593
859656013699	RHS protein; Region: RHS; pfam03527
859656013700	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
859656013701	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
859656013702	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
859656013703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
859656013704	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
859656013705	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
859656013706	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
859656013707	3-hydroxyisobutyryl-CoA hydrolase-like protein; Region: PLN02851
859656013708	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
859656013709	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656013710	putative DNA binding site [nucleotide binding]; other site
859656013711	putative Zn2+ binding site [ion binding]; other site
859656013712	AsnC family; Region: AsnC_trans_reg; pfam01037
859656013713	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656013714	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
859656013715	homotrimer interaction site [polypeptide binding]; other site
859656013716	putative active site [active]
859656013717	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656013718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656013719	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
859656013720	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656013721	MULE transposase domain; Region: MULE; pfam10551
859656013722	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
859656013723	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
859656013724	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
859656013725	DNA-binding site [nucleotide binding]; DNA binding site
859656013726	RNA-binding motif; other site
859656013727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
859656013728	dimer interface [polypeptide binding]; other site
859656013729	phosphorylation site [posttranslational modification]
859656013730	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
859656013731	Methyltransferase domain; Region: Methyltransf_23; pfam13489
859656013732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
859656013733	S-adenosylmethionine binding site [chemical binding]; other site
859656013734	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
859656013735	Evidence 4 : Homologs of previously reported genes of unknown function
859656013736	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656013737	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656013738	putative effector binding pocket; other site
859656013739	dimerization interface [polypeptide binding]; other site
859656013740	hypothetical protein; Provisional; Region: PRK06208
859656013741	intersubunit interface [polypeptide binding]; other site
859656013742	active site
859656013743	Zn2+ binding site [ion binding]; other site
859656013744	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
859656013745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013746	putative substrate translocation pore; other site
859656013747	Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474
859656013748	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
859656013749	EamA-like transporter family; Region: EamA; pfam00892
859656013750	EamA-like transporter family; Region: EamA; pfam00892
859656013751	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656013752	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013753	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656013754	dimerization interface [polypeptide binding]; other site
859656013755	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
859656013756	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
859656013757	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
859656013758	putative N-terminal domain interface [polypeptide binding]; other site
859656013759	putative dimer interface [polypeptide binding]; other site
859656013760	putative substrate binding pocket (H-site) [chemical binding]; other site
859656013761	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
859656013762	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
859656013763	homodimer interface [polypeptide binding]; other site
859656013764	substrate-cofactor binding pocket; other site
859656013765	catalytic residue [active]
859656013766	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
859656013767	Domain of unknown function (DUF802); Region: DUF802; pfam05650
859656013768	Domain of unknown function (DUF802); Region: DUF802; pfam05650
859656013769	hypothetical protein; Provisional; Region: PRK09040
859656013770	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
859656013771	ligand binding site [chemical binding]; other site
859656013772	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
859656013773	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
859656013774	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
859656013775	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
859656013776	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
859656013777	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
859656013778	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
859656013779	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
859656013780	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
859656013781	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
859656013782	Predicted flavoprotein [General function prediction only]; Region: COG0431
859656013783	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
859656013784	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
859656013785	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
859656013786	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
859656013787	putative catalytic residue [active]
859656013788	NnrS protein; Region: NnrS; pfam05940
859656013789	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
859656013790	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
859656013791	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
859656013792	putative acyl-acceptor binding pocket; other site
859656013793	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656013794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013795	active site
859656013796	phosphorylation site [posttranslational modification]
859656013797	intermolecular recognition site; other site
859656013798	dimerization interface [polypeptide binding]; other site
859656013799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656013800	DNA binding residues [nucleotide binding]
859656013801	dimerization interface [polypeptide binding]; other site
859656013802	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
859656013803	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
859656013804	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
859656013805	dimerization interface [polypeptide binding]; other site
859656013806	GAF domain; Region: GAF_3; pfam13492
859656013807	Histidine kinase; Region: HisKA_3; pfam07730
859656013808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013809	ATP binding site [chemical binding]; other site
859656013810	Mg2+ binding site [ion binding]; other site
859656013811	G-X-G motif; other site
859656013812	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
859656013813	Walker A motif; other site
859656013814	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
859656013815	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
859656013816	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
859656013817	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
859656013818	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
859656013819	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
859656013820	[4Fe-4S] binding site [ion binding]; other site
859656013821	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859656013822	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859656013823	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
859656013824	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
859656013825	molybdopterin cofactor binding site; other site
859656013826	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
859656013827	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
859656013828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013829	putative substrate translocation pore; other site
859656013830	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
859656013831	ATP cone domain; Region: ATP-cone; pfam03477
859656013832	Class III ribonucleotide reductase; Region: RNR_III; cd01675
859656013833	effector binding site; other site
859656013834	active site
859656013835	Zn binding site [ion binding]; other site
859656013836	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
859656013837	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
859656013838	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
859656013839	FeS/SAM binding site; other site
859656013840	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
859656013841	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
859656013842	ligand binding site [chemical binding]; other site
859656013843	flexible hinge region; other site
859656013844	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
859656013845	non-specific DNA interactions [nucleotide binding]; other site
859656013846	DNA binding site [nucleotide binding]
859656013847	sequence specific DNA binding site [nucleotide binding]; other site
859656013848	putative cAMP binding site [chemical binding]; other site
859656013849	Uncharacterized conserved protein [Function unknown]; Region: COG4273
859656013850	SCP-2 sterol transfer family; Region: SCP2; cl01225
859656013851	putative protease; Provisional; Region: PRK15447
859656013852	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
859656013853	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
859656013854	Peptidase family U32; Region: Peptidase_U32; pfam01136
859656013855	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
859656013856	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
859656013857	DNA-binding site [nucleotide binding]; DNA binding site
859656013858	UTRA domain; Region: UTRA; pfam07702
859656013859	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
859656013860	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
859656013861	Walker A/P-loop; other site
859656013862	ATP binding site [chemical binding]; other site
859656013863	Q-loop/lid; other site
859656013864	ABC transporter signature motif; other site
859656013865	Walker B; other site
859656013866	D-loop; other site
859656013867	H-loop/switch region; other site
859656013868	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
859656013869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656013870	putative PBP binding loops; other site
859656013871	ABC-ATPase subunit interface; other site
859656013872	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
859656013873	NMT1-like family; Region: NMT1_2; pfam13379
859656013874	Uncharacterized conserved protein [Function unknown]; Region: COG3189
859656013875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656013876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656013877	metal binding site [ion binding]; metal-binding site
859656013878	active site
859656013879	I-site; other site
859656013880	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656013881	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656013882	DNA binding residues [nucleotide binding]
859656013883	dimerization interface [polypeptide binding]; other site
859656013884	Predicted membrane protein [Function unknown]; Region: COG4125
859656013885	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
859656013886	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
859656013887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656013888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656013889	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859656013890	dimerization interface [polypeptide binding]; other site
859656013891	Flagellar protein YcgR; Region: YcgR_2; pfam12945
859656013892	PilZ domain; Region: PilZ; pfam07238
859656013893	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
859656013894	homotrimer interaction site [polypeptide binding]; other site
859656013895	putative active site [active]
859656013896	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
859656013897	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
859656013898	tetramer interface [polypeptide binding]; other site
859656013899	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656013900	catalytic residue [active]
859656013901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
859656013902	YheO-like PAS domain; Region: PAS_6; pfam08348
859656013903	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
859656013904	DNA-binding interface [nucleotide binding]; DNA binding site
859656013905	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
859656013906	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
859656013907	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
859656013908	Sulfate transporter family; Region: Sulfate_transp; pfam00916
859656013909	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
859656013910	Uncharacterized conserved protein [Function unknown]; Region: COG4278
859656013911	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
859656013912	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
859656013913	Predicted integral membrane protein [Function unknown]; Region: COG0392
859656013914	Uncharacterized conserved protein [Function unknown]; Region: COG2898
859656013915	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
859656013916	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
859656013917	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
859656013918	metal binding site [ion binding]; metal-binding site
859656013919	active site
859656013920	I-site; other site
859656013921	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
859656013922	Immunoglobulin domain; Region: Ig; cl11960
859656013923	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
859656013924	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
859656013925	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
859656013926	putative active site [active]
859656013927	catalytic site [active]
859656013928	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
859656013929	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
859656013930	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
859656013931	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
859656013932	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
859656013933	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
859656013934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
859656013935	DDE superfamily endonuclease; Region: DDE_3; pfam13358
859656013936	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
859656013937	PAAR motif; Region: PAAR_motif; cl15808
859656013938	Spore Coat Protein U domain; Region: SCPU; pfam05229
859656013939	Uncharacterized secreted protein [Function unknown]; Region: COG5430
859656013940	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
859656013941	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
859656013942	PapC C-terminal domain; Region: PapC_C; pfam13953
859656013943	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
859656013944	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
859656013945	Uncharacterized secreted protein [Function unknown]; Region: COG5430
859656013946	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
859656013947	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
859656013948	heme binding pocket [chemical binding]; other site
859656013949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3812
859656013950	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
859656013951	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656013952	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656013953	DNA binding residues [nucleotide binding]
859656013954	dimerization interface [polypeptide binding]; other site
859656013955	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
859656013956	thiamine phosphate binding site [chemical binding]; other site
859656013957	active site
859656013958	pyrophosphate binding site [ion binding]; other site
859656013959	metabolite-proton symporter; Region: 2A0106; TIGR00883
859656013960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656013961	putative substrate translocation pore; other site
859656013962	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
859656013963	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
859656013964	putative active site [active]
859656013965	metal binding site [ion binding]; metal-binding site
859656013966	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
859656013967	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
859656013968	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859656013969	protein binding site [polypeptide binding]; other site
859656013970	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
859656013971	protein binding site [polypeptide binding]; other site
859656013972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656013973	dimer interface [polypeptide binding]; other site
859656013974	phosphorylation site [posttranslational modification]
859656013975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656013976	ATP binding site [chemical binding]; other site
859656013977	Mg2+ binding site [ion binding]; other site
859656013978	G-X-G motif; other site
859656013979	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
859656013980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656013981	active site
859656013982	phosphorylation site [posttranslational modification]
859656013983	intermolecular recognition site; other site
859656013984	dimerization interface [polypeptide binding]; other site
859656013985	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
859656013986	DNA binding site [nucleotide binding]
859656013987	NolX protein; Region: NolX; pfam05819
859656013988	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
859656013989	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
859656013990	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
859656013991	putative active site [active]
859656013992	glucokinase; Provisional; Region: glk; PRK00292
859656013993	glucokinase, proteobacterial type; Region: glk; TIGR00749
859656013994	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
859656013995	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
859656013996	putative active site [active]
859656013997	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
859656013998	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
859656013999	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
859656014000	phosphogluconate dehydratase; Validated; Region: PRK09054
859656014001	6-phosphogluconate dehydratase; Region: edd; TIGR01196
859656014002	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
859656014003	Ligand Binding Site [chemical binding]; other site
859656014004	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
859656014005	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
859656014006	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859656014007	Cytochrome c; Region: Cytochrom_C; cl11414
859656014008	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
859656014009	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
859656014010	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
859656014011	Subunit I/III interface [polypeptide binding]; other site
859656014012	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
859656014013	Subunit I/III interface [polypeptide binding]; other site
859656014014	Predicted small integral membrane protein [Function unknown]; Region: COG5605
859656014015	NolX protein; Region: NolX; pfam05819
859656014016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656014017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656014018	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656014019	dimerization interface [polypeptide binding]; other site
859656014020	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
859656014021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656014022	putative substrate translocation pore; other site
859656014023	Uncharacterized conserved protein [Function unknown]; Region: COG5476
859656014024	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
859656014025	MlrC C-terminus; Region: MlrC_C; pfam07171
859656014026	Transcriptional regulator [Transcription]; Region: LysR; COG0583
859656014027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656014028	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
859656014029	dimerization interface [polypeptide binding]; other site
859656014030	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
859656014031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
859656014032	substrate binding pocket [chemical binding]; other site
859656014033	membrane-bound complex binding site; other site
859656014034	hinge residues; other site
859656014035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656014036	dimer interface [polypeptide binding]; other site
859656014037	conserved gate region; other site
859656014038	ABC-ATPase subunit interface; other site
859656014039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
859656014040	dimer interface [polypeptide binding]; other site
859656014041	conserved gate region; other site
859656014042	putative PBP binding loops; other site
859656014043	ABC-ATPase subunit interface; other site
859656014044	agmatinase; Region: agmatinase; TIGR01230
859656014045	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
859656014046	oligomer interface [polypeptide binding]; other site
859656014047	active site
859656014048	Mn binding site [ion binding]; other site
859656014049	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
859656014050	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
859656014051	DNA binding residues [nucleotide binding]
859656014052	dimerization interface [polypeptide binding]; other site
859656014053	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
859656014054	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
859656014055	tetramer interface [polypeptide binding]; other site
859656014056	heme binding pocket [chemical binding]; other site
859656014057	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
859656014058	hypothetical protein; Provisional; Region: PRK05939
859656014059	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
859656014060	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
859656014061	catalytic residue [active]
859656014062	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
859656014063	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
859656014064	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
859656014065	tetrameric interface [polypeptide binding]; other site
859656014066	NAD binding site [chemical binding]; other site
859656014067	catalytic residues [active]
859656014068	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
859656014069	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
859656014070	dimerization interface [polypeptide binding]; other site
859656014071	ligand binding site [chemical binding]; other site
859656014072	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
859656014073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656014074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
859656014075	dimerization interface [polypeptide binding]; other site
859656014076	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
859656014077	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
859656014078	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
859656014079	E3 interaction surface; other site
859656014080	lipoyl attachment site [posttranslational modification]; other site
859656014081	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656014082	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
859656014083	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
859656014084	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
859656014085	active site
859656014086	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859656014087	active site
859656014088	metal binding site [ion binding]; metal-binding site
859656014089	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
859656014090	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
859656014091	succinic semialdehyde dehydrogenase; Region: PLN02278
859656014092	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
859656014093	tetramerization interface [polypeptide binding]; other site
859656014094	NAD(P) binding site [chemical binding]; other site
859656014095	catalytic residues [active]
859656014096	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
859656014097	tartrate dehydrogenase; Region: TTC; TIGR02089
859656014098	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
859656014099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
859656014100	D-galactonate transporter; Region: 2A0114; TIGR00893
859656014101	putative substrate translocation pore; other site
859656014102	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
859656014103	galactarate dehydratase; Region: galactar-dH20; TIGR03248
859656014104	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
859656014105	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859656014106	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656014107	DNA binding site [nucleotide binding]
859656014108	domain linker motif; other site
859656014109	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
859656014110	putative dimerization interface [polypeptide binding]; other site
859656014111	putative ligand binding site [chemical binding]; other site
859656014112	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
859656014113	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
859656014114	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656014115	active site
859656014116	HIGH motif; other site
859656014117	nucleotide binding site [chemical binding]; other site
859656014118	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
859656014119	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
859656014120	active site
859656014121	KMSKS motif; other site
859656014122	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
859656014123	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
859656014124	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
859656014125	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
859656014126	Coenzyme A binding pocket [chemical binding]; other site
859656014127	putative transposase OrfB; Reviewed; Region: PHA02517
859656014128	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
859656014129	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
859656014130	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
859656014131	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
859656014132	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
859656014133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
859656014134	homodimer interface [polypeptide binding]; other site
859656014135	catalytic residue [active]
859656014136	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
859656014137	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
859656014138	putative DNA binding site [nucleotide binding]; other site
859656014139	putative Zn2+ binding site [ion binding]; other site
859656014140	AsnC family; Region: AsnC_trans_reg; pfam01037
859656014141	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
859656014142	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
859656014143	CoenzymeA binding site [chemical binding]; other site
859656014144	subunit interaction site [polypeptide binding]; other site
859656014145	PHB binding site; other site
859656014146	Transposase, Mutator family; Region: Transposase_mut; pfam00872
859656014147	MULE transposase domain; Region: MULE; pfam10551
859656014148	cyanate hydratase; Validated; Region: PRK02866
859656014149	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
859656014150	oligomer interface [polypeptide binding]; other site
859656014151	active site
859656014152	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
859656014153	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
859656014154	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
859656014155	putative ligand binding site [chemical binding]; other site
859656014156	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
859656014157	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
859656014158	Walker A/P-loop; other site
859656014159	ATP binding site [chemical binding]; other site
859656014160	Q-loop/lid; other site
859656014161	ABC transporter signature motif; other site
859656014162	Walker B; other site
859656014163	D-loop; other site
859656014164	H-loop/switch region; other site
859656014165	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
859656014166	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859656014167	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
859656014168	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
859656014169	TM-ABC transporter signature motif; other site
859656014170	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
859656014171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656014172	NAD(P) binding site [chemical binding]; other site
859656014173	active site
859656014174	Transcriptional regulators [Transcription]; Region: PurR; COG1609
859656014175	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
859656014176	DNA binding site [nucleotide binding]
859656014177	domain linker motif; other site
859656014178	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
859656014179	putative dimerization interface [polypeptide binding]; other site
859656014180	putative ligand binding site [chemical binding]; other site
859656014181	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
859656014182	EamA-like transporter family; Region: EamA; pfam00892
859656014183	EamA-like transporter family; Region: EamA; pfam00892
859656014184	Cupin domain; Region: Cupin_2; cl17218
859656014185	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859656014186	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656014187	short chain dehydrogenase; Validated; Region: PRK08264
859656014188	classical (c) SDR, subgroup 7; Region: SDR_c7; cd05354
859656014189	putative NAD(P) binding site [chemical binding]; other site
859656014190	active site
859656014191	Transcriptional regulators [Transcription]; Region: MarR; COG1846
859656014192	MarR family; Region: MarR_2; cl17246
859656014193	transcriptional regulator; Provisional; Region: PRK10632
859656014194	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
859656014195	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
859656014196	putative effector binding pocket; other site
859656014197	dimerization interface [polypeptide binding]; other site
859656014198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
859656014199	NADH(P)-binding; Region: NAD_binding_10; pfam13460
859656014200	NAD(P) binding site [chemical binding]; other site
859656014201	active site
859656014202	Outer membrane efflux protein; Region: OEP; pfam02321
859656014203	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
859656014204	HlyD family secretion protein; Region: HlyD_3; pfam13437
859656014205	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
859656014206	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
859656014207	Uncharacterized conserved protein [Function unknown]; Region: COG5569
859656014208	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
859656014209	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
859656014210	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
859656014211	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
859656014212	MarR family; Region: MarR; pfam01047
859656014213	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
859656014214	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
859656014215	DJ-1 family protein; Region: not_thiJ; TIGR01383
859656014216	conserved cys residue [active]
859656014217	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
859656014218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656014219	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
859656014220	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
859656014221	conserved cys residue [active]
859656014222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
859656014223	non-specific DNA binding site [nucleotide binding]; other site
859656014224	salt bridge; other site
859656014225	sequence-specific DNA binding site [nucleotide binding]; other site
859656014226	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
859656014227	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
859656014228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
859656014229	TPR motif; other site
859656014230	binding surface
859656014231	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
859656014232	Putative zinc-finger; Region: zf-HC2; pfam13490
859656014233	RNA polymerase sigma factor; Provisional; Region: PRK12533
859656014234	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
859656014235	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
859656014236	active site
859656014237	metal binding site [ion binding]; metal-binding site
859656014238	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
859656014239	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
859656014240	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
859656014241	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
859656014242	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
859656014243	G1 box; other site
859656014244	putative GEF interaction site [polypeptide binding]; other site
859656014245	GTP/Mg2+ binding site [chemical binding]; other site
859656014246	Switch I region; other site
859656014247	G2 box; other site
859656014248	G3 box; other site
859656014249	Switch II region; other site
859656014250	G4 box; other site
859656014251	G5 box; other site
859656014252	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
859656014253	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
859656014254	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
859656014255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656014256	active site
859656014257	phosphorylation site [posttranslational modification]
859656014258	intermolecular recognition site; other site
859656014259	dimerization interface [polypeptide binding]; other site
859656014260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656014261	Walker A motif; other site
859656014262	ATP binding site [chemical binding]; other site
859656014263	Walker B motif; other site
859656014264	arginine finger; other site
859656014265	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656014266	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
859656014267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
859656014268	Walker A motif; other site
859656014269	ATP binding site [chemical binding]; other site
859656014270	Walker B motif; other site
859656014271	arginine finger; other site
859656014272	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
859656014273	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
859656014274	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
859656014275	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
859656014276	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
859656014277	Predicted deacetylase [General function prediction only]; Region: COG3233
859656014278	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
859656014279	putative active site [active]
859656014280	putative Zn binding site [ion binding]; other site
859656014281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656014282	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859656014283	putative active site [active]
859656014284	heme pocket [chemical binding]; other site
859656014285	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656014286	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
859656014287	putative active site [active]
859656014288	heme pocket [chemical binding]; other site
859656014289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
859656014290	putative active site [active]
859656014291	heme pocket [chemical binding]; other site
859656014292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
859656014293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
859656014294	dimer interface [polypeptide binding]; other site
859656014295	phosphorylation site [posttranslational modification]
859656014296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
859656014297	ATP binding site [chemical binding]; other site
859656014298	Mg2+ binding site [ion binding]; other site
859656014299	G-X-G motif; other site
859656014300	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
859656014301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
859656014302	active site
859656014303	phosphorylation site [posttranslational modification]
859656014304	intermolecular recognition site; other site
859656014305	dimerization interface [polypeptide binding]; other site
859656014306	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
859656014307	active site
859656014308	Int/Topo IB signature motif; other site
859656014309	DNA binding site [nucleotide binding]
859656014310	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252