-- dump date 20140620_023057 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264198000001 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198000002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000003 substrate binding site [chemical binding]; other site 264198000004 oxyanion hole (OAH) forming residues; other site 264198000005 trimer interface [polypeptide binding]; other site 264198000006 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198000007 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198000008 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198000009 acyl-activating enzyme (AAE) consensus motif; other site 264198000010 acyl-activating enzyme (AAE) consensus motif; other site 264198000011 putative AMP binding site [chemical binding]; other site 264198000012 putative active site [active] 264198000013 putative CoA binding site [chemical binding]; other site 264198000014 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198000015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198000016 catalytic loop [active] 264198000017 iron binding site [ion binding]; other site 264198000018 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198000019 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198000020 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 264198000021 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198000022 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198000023 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198000024 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 264198000025 putative hydrophobic ligand binding site [chemical binding]; other site 264198000026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198000029 dimerization interface [polypeptide binding]; other site 264198000030 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198000031 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198000032 DNA binding site [nucleotide binding] 264198000033 domain linker motif; other site 264198000034 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264198000035 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 264198000036 Dehydratase family; Region: ILVD_EDD; pfam00920 264198000037 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000038 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000039 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198000040 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 264198000041 active site pocket [active] 264198000042 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198000043 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 264198000044 ligand binding site [chemical binding]; other site 264198000045 NAD binding site [chemical binding]; other site 264198000046 dimerization interface [polypeptide binding]; other site 264198000047 catalytic site [active] 264198000048 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264198000049 tartrate dehydrogenase; Region: TTC; TIGR02089 264198000050 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198000051 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198000052 succinic semialdehyde dehydrogenase; Region: PLN02278 264198000053 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198000054 tetramerization interface [polypeptide binding]; other site 264198000055 NAD(P) binding site [chemical binding]; other site 264198000056 catalytic residues [active] 264198000057 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198000058 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 264198000059 dimerization interface [polypeptide binding]; other site 264198000060 ligand binding site [chemical binding]; other site 264198000061 NADP binding site [chemical binding]; other site 264198000062 catalytic site [active] 264198000063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000064 DNA-binding site [nucleotide binding]; DNA binding site 264198000065 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198000066 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264198000067 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264198000068 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198000069 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198000070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198000071 Walker A/P-loop; other site 264198000072 ATP binding site [chemical binding]; other site 264198000073 Q-loop/lid; other site 264198000074 ABC transporter signature motif; other site 264198000075 Walker B; other site 264198000076 D-loop; other site 264198000077 H-loop/switch region; other site 264198000078 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 264198000079 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264198000080 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 264198000081 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198000082 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 264198000083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198000084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000085 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 264198000086 PRC-barrel domain; Region: PRC; pfam05239 264198000087 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 264198000088 Clp amino terminal domain; Region: Clp_N; pfam02861 264198000089 Clp amino terminal domain; Region: Clp_N; pfam02861 264198000090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000091 Walker A motif; other site 264198000092 ATP binding site [chemical binding]; other site 264198000093 Walker B motif; other site 264198000094 arginine finger; other site 264198000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000096 Walker A motif; other site 264198000097 ATP binding site [chemical binding]; other site 264198000098 Walker B motif; other site 264198000099 arginine finger; other site 264198000100 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264198000101 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198000102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198000103 non-specific DNA binding site [nucleotide binding]; other site 264198000104 salt bridge; other site 264198000105 sequence-specific DNA binding site [nucleotide binding]; other site 264198000106 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 264198000107 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198000108 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198000109 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198000110 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198000111 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198000112 active site 264198000113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198000114 homotrimer interaction site [polypeptide binding]; other site 264198000115 putative active site [active] 264198000116 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000117 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264198000118 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198000119 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198000120 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198000121 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 264198000122 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198000123 NAD(P) binding site [chemical binding]; other site 264198000124 catalytic residues [active] 264198000125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 264198000126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198000127 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264198000128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264198000129 Transposase; Region: HTH_Tnp_1; cl17663 264198000130 putative transposase OrfB; Reviewed; Region: PHA02517 264198000131 HTH-like domain; Region: HTH_21; pfam13276 264198000132 Integrase core domain; Region: rve; pfam00665 264198000133 Integrase core domain; Region: rve_3; pfam13683 264198000134 acyl-CoA synthetase; Validated; Region: PRK08162 264198000135 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 264198000136 acyl-activating enzyme (AAE) consensus motif; other site 264198000137 putative active site [active] 264198000138 AMP binding site [chemical binding]; other site 264198000139 putative CoA binding site [chemical binding]; other site 264198000140 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198000141 putative FMN binding site [chemical binding]; other site 264198000142 benzoate transport; Region: 2A0115; TIGR00895 264198000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000144 putative substrate translocation pore; other site 264198000145 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 264198000146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000147 NAD(P) binding site [chemical binding]; other site 264198000148 active site 264198000149 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264198000150 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198000151 dimer interface [polypeptide binding]; other site 264198000152 active site 264198000153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198000154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198000155 ligand binding site [chemical binding]; other site 264198000156 flexible hinge region; other site 264198000157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198000158 putative switch regulator; other site 264198000159 non-specific DNA interactions [nucleotide binding]; other site 264198000160 DNA binding site [nucleotide binding] 264198000161 sequence specific DNA binding site [nucleotide binding]; other site 264198000162 putative cAMP binding site [chemical binding]; other site 264198000163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198000164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198000165 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264198000166 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198000167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000168 DNA-binding site [nucleotide binding]; DNA binding site 264198000169 FCD domain; Region: FCD; pfam07729 264198000170 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198000171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000172 substrate binding site [chemical binding]; other site 264198000173 oxyanion hole (OAH) forming residues; other site 264198000174 trimer interface [polypeptide binding]; other site 264198000175 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000176 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000177 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000178 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 264198000179 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198000180 putative NAD(P) binding site [chemical binding]; other site 264198000181 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198000182 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198000183 TM-ABC transporter signature motif; other site 264198000184 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198000185 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198000186 TM-ABC transporter signature motif; other site 264198000187 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198000188 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198000189 Walker A/P-loop; other site 264198000190 ATP binding site [chemical binding]; other site 264198000191 Q-loop/lid; other site 264198000192 ABC transporter signature motif; other site 264198000193 Walker B; other site 264198000194 D-loop; other site 264198000195 H-loop/switch region; other site 264198000196 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198000197 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198000198 Walker A/P-loop; other site 264198000199 ATP binding site [chemical binding]; other site 264198000200 Q-loop/lid; other site 264198000201 ABC transporter signature motif; other site 264198000202 Walker B; other site 264198000203 D-loop; other site 264198000204 H-loop/switch region; other site 264198000205 Branched-chain amino acid ATP-binding cassette transporter; Region: BCA_ABC_TP_C; pfam12399 264198000206 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198000207 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198000208 putative ligand binding site [chemical binding]; other site 264198000209 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198000210 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 264198000211 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198000212 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198000213 NAD(P) binding site [chemical binding]; other site 264198000214 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198000215 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 264198000216 tetrameric interface [polypeptide binding]; other site 264198000217 NAD binding site [chemical binding]; other site 264198000218 catalytic residues [active] 264198000219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000222 dimerization interface [polypeptide binding]; other site 264198000223 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 264198000224 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198000225 active site 264198000226 DNA binding site [nucleotide binding] 264198000227 Int/Topo IB signature motif; other site 264198000228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000229 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198000230 putative substrate translocation pore; other site 264198000231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198000232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198000233 Coenzyme A binding pocket [chemical binding]; other site 264198000234 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264198000235 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000236 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000237 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000238 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000239 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000240 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000241 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000242 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000243 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000244 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 264198000245 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264198000246 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198000247 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 264198000248 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 264198000249 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264198000250 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 264198000251 Walker A/P-loop; other site 264198000252 ATP binding site [chemical binding]; other site 264198000253 Q-loop/lid; other site 264198000254 ABC transporter signature motif; other site 264198000255 Walker B; other site 264198000256 D-loop; other site 264198000257 H-loop/switch region; other site 264198000258 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264198000259 Transposase domain (DUF772); Region: DUF772; pfam05598 264198000260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198000261 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264198000262 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198000263 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198000264 conserved cys residue [active] 264198000265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000266 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264198000267 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 264198000268 conserved cys residue [active] 264198000269 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000270 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198000271 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264198000272 N-terminal domain interface [polypeptide binding]; other site 264198000273 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 264198000274 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264198000275 Amidase; Region: Amidase; pfam01425 264198000276 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198000277 active site 264198000278 dimer interface [polypeptide binding]; other site 264198000279 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 264198000280 metal binding site [ion binding]; metal-binding site 264198000281 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198000282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000284 dimerization interface [polypeptide binding]; other site 264198000285 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198000286 putative FMN binding site [chemical binding]; other site 264198000287 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 264198000288 Zn binding site [ion binding]; other site 264198000289 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 264198000290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198000291 Zn binding site [ion binding]; other site 264198000292 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198000293 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198000294 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 264198000295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264198000296 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264198000297 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 264198000298 IHF - DNA interface [nucleotide binding]; other site 264198000299 IHF dimer interface [polypeptide binding]; other site 264198000300 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264198000301 active site 264198000302 Int/Topo IB signature motif; other site 264198000303 catalytic residues [active] 264198000304 DNA binding site [nucleotide binding] 264198000305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198000306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198000307 non-specific DNA binding site [nucleotide binding]; other site 264198000308 salt bridge; other site 264198000309 sequence-specific DNA binding site [nucleotide binding]; other site 264198000310 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 264198000311 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 264198000312 RES domain; Region: RES; pfam08808 264198000313 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 264198000314 Archaeal ATPase; Region: Arch_ATPase; pfam01637 264198000315 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 264198000316 H-NS histone family; Region: Histone_HNS; pfam00816 264198000317 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198000318 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 264198000319 nudix motif; other site 264198000320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264198000321 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264198000322 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264198000323 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198000324 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264198000325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198000326 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198000327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198000328 DNA binding residues [nucleotide binding] 264198000329 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198000330 DNA-binding site [nucleotide binding]; DNA binding site 264198000331 RNA-binding motif; other site 264198000332 Cache domain; Region: Cache_1; pfam02743 264198000333 HAMP domain; Region: HAMP; pfam00672 264198000334 PAS fold; Region: PAS_4; pfam08448 264198000335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198000336 putative active site [active] 264198000337 heme pocket [chemical binding]; other site 264198000338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198000339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198000340 metal binding site [ion binding]; metal-binding site 264198000341 active site 264198000342 I-site; other site 264198000343 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 264198000344 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198000345 NAD(P) binding site [chemical binding]; other site 264198000346 homotetramer interface [polypeptide binding]; other site 264198000347 homodimer interface [polypeptide binding]; other site 264198000348 active site 264198000349 Phasin protein; Region: Phasin_2; pfam09361 264198000350 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 264198000351 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 264198000352 active site 264198000353 nucleophile elbow; other site 264198000354 CHASE domain; Region: CHASE; pfam03924 264198000355 GAF domain; Region: GAF_2; pfam13185 264198000356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198000357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198000358 metal binding site [ion binding]; metal-binding site 264198000359 active site 264198000360 I-site; other site 264198000361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198000362 Uncharacterized conserved protein [Function unknown]; Region: COG4278 264198000363 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198000364 DNA-binding site [nucleotide binding]; DNA binding site 264198000365 RNA-binding motif; other site 264198000366 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 264198000367 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 264198000368 DXD motif; other site 264198000369 PilZ domain; Region: PilZ; pfam07238 264198000370 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 264198000371 benzoate transport; Region: 2A0115; TIGR00895 264198000372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000373 putative substrate translocation pore; other site 264198000374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000375 putative substrate translocation pore; other site 264198000376 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198000377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000378 NAD(P) binding site [chemical binding]; other site 264198000379 active site 264198000380 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198000381 classical (c) SDRs; Region: SDR_c; cd05233 264198000382 NAD(P) binding site [chemical binding]; other site 264198000383 active site 264198000384 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198000385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000386 substrate binding site [chemical binding]; other site 264198000387 oxyanion hole (OAH) forming residues; other site 264198000388 trimer interface [polypeptide binding]; other site 264198000389 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 264198000390 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198000391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198000392 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264198000393 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000394 active site 1 [active] 264198000395 dimer interface [polypeptide binding]; other site 264198000396 hexamer interface [polypeptide binding]; other site 264198000397 active site 2 [active] 264198000398 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000399 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 264198000400 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198000401 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198000402 Predicted transcriptional regulators [Transcription]; Region: COG1733 264198000403 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264198000404 benzoate transport; Region: 2A0115; TIGR00895 264198000405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000406 putative substrate translocation pore; other site 264198000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000408 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000409 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198000410 Beta-lactamase; Region: Beta-lactamase; pfam00144 264198000411 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000412 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264198000413 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264198000414 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 264198000415 putative NAD(P) binding site [chemical binding]; other site 264198000416 active site 264198000417 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198000418 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198000419 FMN binding site [chemical binding]; other site 264198000420 substrate binding site [chemical binding]; other site 264198000421 putative catalytic residue [active] 264198000422 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198000423 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198000424 putative catalytic residue [active] 264198000425 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198000426 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 264198000427 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198000428 acyl-activating enzyme (AAE) consensus motif; other site 264198000429 acyl-activating enzyme (AAE) consensus motif; other site 264198000430 putative AMP binding site [chemical binding]; other site 264198000431 putative active site [active] 264198000432 CoA binding site [chemical binding]; other site 264198000433 putative CoA binding site [chemical binding]; other site 264198000434 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198000435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198000437 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198000438 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198000439 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198000440 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198000441 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198000442 ligand binding site [chemical binding]; other site 264198000443 homodimer interface [polypeptide binding]; other site 264198000444 NAD(P) binding site [chemical binding]; other site 264198000445 trimer interface B [polypeptide binding]; other site 264198000446 trimer interface A [polypeptide binding]; other site 264198000447 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198000448 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198000449 putative catalytic residue [active] 264198000450 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 264198000451 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198000452 dimer interface [polypeptide binding]; other site 264198000453 active site 264198000454 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 264198000455 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 264198000456 putative NAD(P) binding site [chemical binding]; other site 264198000457 active site 264198000458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198000459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198000460 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 264198000461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198000462 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264198000463 acyl-activating enzyme (AAE) consensus motif; other site 264198000464 putative AMP binding site [chemical binding]; other site 264198000465 putative active site [active] 264198000466 putative CoA binding site [chemical binding]; other site 264198000467 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198000468 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198000469 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198000470 active site 264198000471 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198000472 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 264198000473 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264198000474 NADP binding site [chemical binding]; other site 264198000475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000476 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198000477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000478 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198000479 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 264198000481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198000482 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 264198000483 acyl-CoA synthetase; Provisional; Region: PRK12582 264198000484 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 264198000485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198000486 FeS/SAM binding site; other site 264198000487 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 264198000488 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198000489 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198000490 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198000491 ligand binding site [chemical binding]; other site 264198000492 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 264198000493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198000494 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198000495 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198000496 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 264198000497 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000498 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264198000499 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 264198000500 NAD binding site [chemical binding]; other site 264198000501 substrate binding site [chemical binding]; other site 264198000502 catalytic Zn binding site [ion binding]; other site 264198000503 structural Zn binding site [ion binding]; other site 264198000504 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198000505 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198000506 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198000507 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198000508 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198000509 ligand binding site [chemical binding]; other site 264198000510 homodimer interface [polypeptide binding]; other site 264198000511 NAD(P) binding site [chemical binding]; other site 264198000512 trimer interface B [polypeptide binding]; other site 264198000513 trimer interface A [polypeptide binding]; other site 264198000514 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000515 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198000516 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198000517 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 264198000518 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 264198000519 putative NAD(P) binding site [chemical binding]; other site 264198000520 catalytic Zn binding site [ion binding]; other site 264198000521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000522 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198000523 putative substrate translocation pore; other site 264198000524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000525 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198000526 NAD(P) binding site [chemical binding]; other site 264198000527 active site 264198000528 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264198000529 histidinol dehydrogenase; Region: hisD; TIGR00069 264198000530 NAD binding site [chemical binding]; other site 264198000531 dimerization interface [polypeptide binding]; other site 264198000532 product binding site; other site 264198000533 substrate binding site [chemical binding]; other site 264198000534 zinc binding site [ion binding]; other site 264198000535 catalytic residues [active] 264198000536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198000537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198000538 DNA binding site [nucleotide binding] 264198000539 domain linker motif; other site 264198000540 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 264198000541 putative dimerization interface [polypeptide binding]; other site 264198000542 putative ligand binding site [chemical binding]; other site 264198000543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198000544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198000545 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 264198000546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198000547 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 264198000548 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 264198000549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198000550 S-adenosylmethionine binding site [chemical binding]; other site 264198000551 MFS/sugar transport protein; Region: MFS_2; pfam13347 264198000552 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 264198000553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000554 NAD(P) binding site [chemical binding]; other site 264198000555 active site 264198000556 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198000557 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198000558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198000559 substrate binding pocket [chemical binding]; other site 264198000560 membrane-bound complex binding site; other site 264198000561 hinge residues; other site 264198000562 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 264198000563 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198000564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000565 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 264198000566 substrate binding site [chemical binding]; other site 264198000567 oxyanion hole (OAH) forming residues; other site 264198000568 trimer interface [polypeptide binding]; other site 264198000569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000570 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264198000571 substrate binding site [chemical binding]; other site 264198000572 oxyanion hole (OAH) forming residues; other site 264198000573 trimer interface [polypeptide binding]; other site 264198000574 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 264198000575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000576 NAD(P) binding site [chemical binding]; other site 264198000577 active site 264198000578 acyl-CoA synthetase; Validated; Region: PRK08162 264198000579 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 264198000580 acyl-activating enzyme (AAE) consensus motif; other site 264198000581 putative active site [active] 264198000582 AMP binding site [chemical binding]; other site 264198000583 putative CoA binding site [chemical binding]; other site 264198000584 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 264198000585 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 264198000586 active site 264198000587 FMN binding site [chemical binding]; other site 264198000588 2,4-decadienoyl-CoA binding site; other site 264198000589 catalytic residue [active] 264198000590 4Fe-4S cluster binding site [ion binding]; other site 264198000591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198000592 MarR family; Region: MarR_2; cl17246 264198000593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198000594 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198000595 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198000596 Cupin; Region: Cupin_6; pfam12852 264198000597 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198000598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000602 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198000603 dimerization interface [polypeptide binding]; other site 264198000604 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 264198000605 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198000606 putative NAD(P) binding site [chemical binding]; other site 264198000607 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264198000608 catalytic residue [active] 264198000609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198000610 Coenzyme A binding pocket [chemical binding]; other site 264198000611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198000612 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198000613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000614 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198000615 putative effector binding pocket; other site 264198000616 dimerization interface [polypeptide binding]; other site 264198000617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000619 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198000620 dimerization interface [polypeptide binding]; other site 264198000621 substrate binding pocket [chemical binding]; other site 264198000622 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 264198000623 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 264198000624 putative active site [active] 264198000625 Zn binding site [ion binding]; other site 264198000626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198000628 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198000629 homotrimer interaction site [polypeptide binding]; other site 264198000630 putative active site [active] 264198000631 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198000632 Zn2+ binding site [ion binding]; other site 264198000633 Mg2+ binding site [ion binding]; other site 264198000634 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264198000635 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264198000636 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 264198000637 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198000638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000639 DNA-binding site [nucleotide binding]; DNA binding site 264198000640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198000641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198000642 homodimer interface [polypeptide binding]; other site 264198000643 catalytic residue [active] 264198000644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198000645 Zn2+ binding site [ion binding]; other site 264198000646 Mg2+ binding site [ion binding]; other site 264198000647 short chain dehydrogenase; Provisional; Region: PRK07577 264198000648 classical (c) SDRs; Region: SDR_c; cd05233 264198000649 NAD(P) binding site [chemical binding]; other site 264198000650 active site 264198000651 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264198000652 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264198000653 putative active site [active] 264198000654 putative metal binding site [ion binding]; other site 264198000655 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198000656 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 264198000657 NAD(P) binding site [chemical binding]; other site 264198000658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000661 dimerization interface [polypeptide binding]; other site 264198000662 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198000663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198000664 non-specific DNA binding site [nucleotide binding]; other site 264198000665 salt bridge; other site 264198000666 sequence-specific DNA binding site [nucleotide binding]; other site 264198000667 HipA N-terminal domain; Region: Couple_hipA; pfam13657 264198000668 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264198000669 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264198000670 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 264198000671 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264198000672 active site 264198000673 metal binding site [ion binding]; metal-binding site 264198000674 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 264198000675 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 264198000676 Initiator Replication protein; Region: Rep_3; pfam01051 264198000677 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264198000678 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198000679 P-loop; other site 264198000680 Magnesium ion binding site [ion binding]; other site 264198000681 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198000682 Magnesium ion binding site [ion binding]; other site 264198000683 ParB-like nuclease domain; Region: ParB; smart00470 264198000684 Phage integrase protein; Region: DUF3701; pfam12482 264198000685 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 264198000686 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198000687 active site 264198000688 DNA binding site [nucleotide binding] 264198000689 Int/Topo IB signature motif; other site 264198000690 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198000691 Double zinc ribbon; Region: DZR; pfam12773 264198000692 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198000693 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264198000694 cyclase homology domain; Region: CHD; cd07302 264198000695 nucleotidyl binding site; other site 264198000696 metal binding site [ion binding]; metal-binding site 264198000697 dimer interface [polypeptide binding]; other site 264198000698 AAA ATPase domain; Region: AAA_16; pfam13191 264198000699 Predicted ATPase [General function prediction only]; Region: COG3903 264198000700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198000701 non-specific DNA binding site [nucleotide binding]; other site 264198000702 salt bridge; other site 264198000703 sequence-specific DNA binding site [nucleotide binding]; other site 264198000704 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264198000705 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264198000706 putative active site [active] 264198000707 putative metal binding site [ion binding]; other site 264198000708 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198000709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000710 Walker A motif; other site 264198000711 ATP binding site [chemical binding]; other site 264198000712 Walker B motif; other site 264198000713 arginine finger; other site 264198000714 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198000715 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198000716 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198000717 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198000718 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 264198000719 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198000720 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264198000721 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 264198000722 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 264198000723 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198000724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198000725 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198000726 acyl-activating enzyme (AAE) consensus motif; other site 264198000727 acyl-activating enzyme (AAE) consensus motif; other site 264198000728 putative AMP binding site [chemical binding]; other site 264198000729 putative active site [active] 264198000730 putative CoA binding site [chemical binding]; other site 264198000731 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 264198000732 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264198000733 oligomeric interface; other site 264198000734 putative active site [active] 264198000735 homodimer interface [polypeptide binding]; other site 264198000736 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264198000737 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198000738 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264198000739 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198000740 Transposase; Region: HTH_Tnp_1; pfam01527 264198000741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264198000742 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 264198000743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264198000744 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264198000745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264198000746 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 264198000747 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 264198000748 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264198000749 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 264198000750 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264198000751 acyl-activating enzyme (AAE) consensus motif; other site 264198000752 putative AMP binding site [chemical binding]; other site 264198000753 putative active site [active] 264198000754 putative CoA binding site [chemical binding]; other site 264198000755 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 264198000756 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 264198000757 putative NAD(P) binding site [chemical binding]; other site 264198000758 homodimer interface [polypeptide binding]; other site 264198000759 Acylphosphatase; Region: Acylphosphatase; pfam00708 264198000760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198000762 putative substrate translocation pore; other site 264198000763 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 264198000764 FtsH Extracellular; Region: FtsH_ext; pfam06480 264198000765 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264198000766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000767 Walker A motif; other site 264198000768 ATP binding site [chemical binding]; other site 264198000769 Walker B motif; other site 264198000770 arginine finger; other site 264198000771 Peptidase family M41; Region: Peptidase_M41; pfam01434 264198000772 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 264198000773 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 264198000774 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 264198000775 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198000776 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264198000777 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941 264198000778 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 264198000779 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 264198000780 Repair protein; Region: Repair_PSII; pfam04536 264198000781 Repair protein; Region: Repair_PSII; pfam04536 264198000782 Predicted membrane protein [Function unknown]; Region: COG3174 264198000783 MarR family; Region: MarR_2; cl17246 264198000784 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198000785 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198000786 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 264198000787 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198000788 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198000789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000790 putative substrate translocation pore; other site 264198000791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000793 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198000794 putative effector binding pocket; other site 264198000795 dimerization interface [polypeptide binding]; other site 264198000796 Abhydrolase family; Region: Abhydrolase_7; pfam12715 264198000797 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198000798 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 264198000799 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198000800 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 264198000801 putative ligand binding site [chemical binding]; other site 264198000802 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198000803 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198000804 TM-ABC transporter signature motif; other site 264198000805 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198000806 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198000807 TM-ABC transporter signature motif; other site 264198000808 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198000809 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198000810 Walker A/P-loop; other site 264198000811 ATP binding site [chemical binding]; other site 264198000812 Q-loop/lid; other site 264198000813 ABC transporter signature motif; other site 264198000814 Walker B; other site 264198000815 D-loop; other site 264198000816 H-loop/switch region; other site 264198000817 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198000818 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198000819 Walker A/P-loop; other site 264198000820 ATP binding site [chemical binding]; other site 264198000821 Q-loop/lid; other site 264198000822 ABC transporter signature motif; other site 264198000823 Walker B; other site 264198000824 D-loop; other site 264198000825 H-loop/switch region; other site 264198000826 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000827 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198000828 eyelet of channel; other site 264198000829 trimer interface [polypeptide binding]; other site 264198000830 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198000831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198000832 putative DNA binding site [nucleotide binding]; other site 264198000833 putative Zn2+ binding site [ion binding]; other site 264198000834 AsnC family; Region: AsnC_trans_reg; pfam01037 264198000835 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198000836 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198000837 dimer interface [polypeptide binding]; other site 264198000838 PYR/PP interface [polypeptide binding]; other site 264198000839 TPP binding site [chemical binding]; other site 264198000840 substrate binding site [chemical binding]; other site 264198000841 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198000842 TPP-binding site [chemical binding]; other site 264198000843 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264198000844 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198000845 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 264198000846 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 264198000847 NAD binding site [chemical binding]; other site 264198000848 Phe binding site; other site 264198000849 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198000850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000851 DNA-binding site [nucleotide binding]; DNA binding site 264198000852 FCD domain; Region: FCD; pfam07729 264198000853 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264198000854 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264198000855 trimer interface [polypeptide binding]; other site 264198000856 putative metal binding site [ion binding]; other site 264198000857 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198000858 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264198000859 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198000860 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198000861 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 264198000862 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000863 classical (c) SDRs; Region: SDR_c; cd05233 264198000864 NAD(P) binding site [chemical binding]; other site 264198000865 active site 264198000866 short chain dehydrogenase; Provisional; Region: PRK12829 264198000867 classical (c) SDRs; Region: SDR_c; cd05233 264198000868 NAD(P) binding site [chemical binding]; other site 264198000869 active site 264198000870 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198000871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000873 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 264198000874 putative substrate binding pocket [chemical binding]; other site 264198000875 putative dimerization interface [polypeptide binding]; other site 264198000876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000877 putative substrate translocation pore; other site 264198000878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198000879 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198000880 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000881 trimer interface [polypeptide binding]; other site 264198000882 eyelet of channel; other site 264198000883 hypothetical protein; Provisional; Region: PRK08244 264198000884 hypothetical protein; Provisional; Region: PRK07236 264198000885 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198000886 hypothetical protein; Provisional; Region: PRK08204 264198000887 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198000888 active site 264198000889 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198000890 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264198000891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198000892 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198000893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198000894 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 264198000895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198000896 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198000897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198000898 active site 264198000899 metal binding site [ion binding]; metal-binding site 264198000900 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 264198000901 Fasciclin domain; Region: Fasciclin; pfam02469 264198000902 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 264198000903 Fasciclin domain; Region: Fasciclin; pfam02469 264198000904 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 264198000905 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 264198000906 DNA binding residues [nucleotide binding] 264198000907 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264198000908 B12 binding domain; Region: B12-binding_2; pfam02607 264198000909 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198000910 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198000911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198000912 dimer interface [polypeptide binding]; other site 264198000913 putative CheW interface [polypeptide binding]; other site 264198000914 Integrase core domain; Region: rve; pfam00665 264198000915 Integrase core domain; Region: rve_3; cl15866 264198000916 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 264198000917 Integrase core domain; Region: rve; pfam00665 264198000918 AAA ATPase domain; Region: AAA_16; pfam13191 264198000919 AAA domain; Region: AAA_22; pfam13401 264198000920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000922 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198000923 putative dimerization interface [polypeptide binding]; other site 264198000924 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198000925 active site 264198000926 catalytic residues [active] 264198000927 metal binding site [ion binding]; metal-binding site 264198000928 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000929 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000930 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000931 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264198000932 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264198000933 trimer interface [polypeptide binding]; other site 264198000934 putative metal binding site [ion binding]; other site 264198000935 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198000936 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000937 trimer interface [polypeptide binding]; other site 264198000938 eyelet of channel; other site 264198000939 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264198000940 metal binding site [ion binding]; metal-binding site 264198000941 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264198000942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198000943 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198000944 putative dimerization interface [polypeptide binding]; other site 264198000945 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198000946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000947 substrate binding site [chemical binding]; other site 264198000948 oxyanion hole (OAH) forming residues; other site 264198000949 trimer interface [polypeptide binding]; other site 264198000950 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000951 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000952 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198000953 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 264198000954 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264198000955 phosphate binding site [ion binding]; other site 264198000956 Bacterial TniB protein; Region: TniB; pfam05621 264198000957 AAA domain; Region: AAA_22; pfam13401 264198000958 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198000959 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198000960 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198000961 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198000962 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198000963 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 264198000964 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198000965 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264198000966 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198000967 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198000968 putative ligand binding site [chemical binding]; other site 264198000969 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198000970 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198000971 Walker A/P-loop; other site 264198000972 ATP binding site [chemical binding]; other site 264198000973 Q-loop/lid; other site 264198000974 ABC transporter signature motif; other site 264198000975 Walker B; other site 264198000976 D-loop; other site 264198000977 H-loop/switch region; other site 264198000978 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198000979 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198000980 Walker A/P-loop; other site 264198000981 ATP binding site [chemical binding]; other site 264198000982 Q-loop/lid; other site 264198000983 ABC transporter signature motif; other site 264198000984 Walker B; other site 264198000985 D-loop; other site 264198000986 H-loop/switch region; other site 264198000987 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198000988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198000989 TM-ABC transporter signature motif; other site 264198000990 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198000991 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198000992 TM-ABC transporter signature motif; other site 264198000993 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198000994 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264198000995 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 264198000996 succinic semialdehyde dehydrogenase; Region: PLN02278 264198000997 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198000998 tetramerization interface [polypeptide binding]; other site 264198000999 NAD(P) binding site [chemical binding]; other site 264198001000 catalytic residues [active] 264198001001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198001004 dimerization interface [polypeptide binding]; other site 264198001005 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 264198001006 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198001007 inhibitor-cofactor binding pocket; inhibition site 264198001008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198001009 catalytic residue [active] 264198001010 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198001011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001012 NAD(P) binding site [chemical binding]; other site 264198001013 active site 264198001014 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198001015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198001016 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198001017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 264198001018 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 264198001019 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198001020 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198001021 short chain dehydrogenase; Provisional; Region: PRK07577 264198001022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001023 NAD(P) binding site [chemical binding]; other site 264198001024 active site 264198001025 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198001026 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198001027 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198001028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198001030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198001031 substrate binding site [chemical binding]; other site 264198001032 oxyanion hole (OAH) forming residues; other site 264198001033 trimer interface [polypeptide binding]; other site 264198001034 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 264198001035 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198001036 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 264198001037 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198001038 Protein export membrane protein; Region: SecD_SecF; cl14618 264198001039 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198001040 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264198001041 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198001042 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198001043 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198001044 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198001045 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198001046 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198001047 active site 264198001048 oxalacetate binding site [chemical binding]; other site 264198001049 citrylCoA binding site [chemical binding]; other site 264198001050 coenzyme A binding site [chemical binding]; other site 264198001051 catalytic triad [active] 264198001052 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 264198001053 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198001054 active site 264198001055 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264198001056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001057 NAD(P) binding site [chemical binding]; other site 264198001058 active site 264198001059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001062 active site 264198001063 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198001064 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198001065 substrate binding site [chemical binding]; other site 264198001066 oxyanion hole (OAH) forming residues; other site 264198001067 trimer interface [polypeptide binding]; other site 264198001068 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198001069 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198001070 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198001071 putative FMN binding site [chemical binding]; other site 264198001072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001074 active site 264198001075 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198001076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001077 putative substrate translocation pore; other site 264198001078 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198001079 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198001080 trimer interface [polypeptide binding]; other site 264198001081 eyelet of channel; other site 264198001082 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198001084 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264198001085 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 264198001086 NMT1/THI5 like; Region: NMT1; pfam09084 264198001087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 264198001088 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 264198001089 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 264198001090 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 264198001091 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 264198001092 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 264198001093 classical (c) SDRs; Region: SDR_c; cd05233 264198001094 NAD(P) binding site [chemical binding]; other site 264198001095 active site 264198001096 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001097 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198001098 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198001099 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198001100 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198001101 active site 264198001102 oxalacetate binding site [chemical binding]; other site 264198001103 citrylCoA binding site [chemical binding]; other site 264198001104 coenzyme A binding site [chemical binding]; other site 264198001105 catalytic triad [active] 264198001106 Cache domain; Region: Cache_1; pfam02743 264198001107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198001108 dimerization interface [polypeptide binding]; other site 264198001109 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198001110 dimer interface [polypeptide binding]; other site 264198001111 putative CheW interface [polypeptide binding]; other site 264198001112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198001113 MarR family; Region: MarR_2; pfam12802 264198001114 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198001115 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198001116 NAD(P) binding site [chemical binding]; other site 264198001117 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198001118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198001119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198001120 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198001121 [2Fe-2S] cluster binding site [ion binding]; other site 264198001122 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198001123 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198001124 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198001125 hydrophobic ligand binding site; other site 264198001126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001127 NAD(P) binding site [chemical binding]; other site 264198001128 active site 264198001129 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198001130 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198001131 Walker A/P-loop; other site 264198001132 ATP binding site [chemical binding]; other site 264198001133 Q-loop/lid; other site 264198001134 ABC transporter signature motif; other site 264198001135 Walker B; other site 264198001136 D-loop; other site 264198001137 H-loop/switch region; other site 264198001138 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198001139 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198001140 Walker A/P-loop; other site 264198001141 ATP binding site [chemical binding]; other site 264198001142 Q-loop/lid; other site 264198001143 ABC transporter signature motif; other site 264198001144 Walker B; other site 264198001145 D-loop; other site 264198001146 H-loop/switch region; other site 264198001147 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198001148 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198001149 TM-ABC transporter signature motif; other site 264198001150 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198001151 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198001152 TM-ABC transporter signature motif; other site 264198001153 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198001154 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198001155 putative ligand binding site [chemical binding]; other site 264198001156 cysteine desulfurase; Provisional; Region: PRK14012 264198001157 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264198001158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198001159 catalytic residue [active] 264198001160 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198001161 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198001162 trimer interface [polypeptide binding]; other site 264198001163 eyelet of channel; other site 264198001164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264198001165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264198001166 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264198001167 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198001168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198001169 TfoX N-terminal domain; Region: TfoX_N; pfam04993 264198001170 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 264198001171 SnoaL-like domain; Region: SnoaL_3; pfam13474 264198001172 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264198001173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264198001174 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 264198001175 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 264198001176 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264198001177 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 264198001178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264198001179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264198001180 Transposase; Region: HTH_Tnp_1; pfam01527 264198001181 amidase; Provisional; Region: PRK07056 264198001182 Amidase; Region: Amidase; cl11426 264198001183 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 264198001184 Helix-turn-helix domain; Region: HTH_37; pfam13744 264198001185 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 264198001186 putative active site [active] 264198001187 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 264198001188 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198001189 H-NS histone family; Region: Histone_HNS; pfam00816 264198001190 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198001191 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 264198001192 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198001193 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264198001194 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 264198001195 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264198001196 SnoaL-like domain; Region: SnoaL_4; pfam13577 264198001197 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 264198001198 dimer interaction site [polypeptide binding]; other site 264198001199 substrate-binding tunnel; other site 264198001200 active site 264198001201 catalytic site [active] 264198001202 substrate binding site [chemical binding]; other site 264198001203 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 264198001204 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198001205 dimer interface [polypeptide binding]; other site 264198001206 active site 264198001207 citrylCoA binding site [chemical binding]; other site 264198001208 NADH binding [chemical binding]; other site 264198001209 cationic pore residues; other site 264198001210 oxalacetate/citrate binding site [chemical binding]; other site 264198001211 coenzyme A binding site [chemical binding]; other site 264198001212 catalytic triad [active] 264198001213 citrate-proton symporter; Provisional; Region: PRK15075 264198001214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001215 putative substrate translocation pore; other site 264198001216 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198001217 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198001218 dimer interface [polypeptide binding]; other site 264198001219 PYR/PP interface [polypeptide binding]; other site 264198001220 TPP binding site [chemical binding]; other site 264198001221 substrate binding site [chemical binding]; other site 264198001222 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198001223 TPP-binding site [chemical binding]; other site 264198001224 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264198001225 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198001226 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198001227 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198001228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198001229 DNA-binding site [nucleotide binding]; DNA binding site 264198001230 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198001231 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198001232 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198001233 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198001234 NAD(P) binding site [chemical binding]; other site 264198001235 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198001236 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198001237 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198001238 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198001239 ligand binding site [chemical binding]; other site 264198001240 homodimer interface [polypeptide binding]; other site 264198001241 NAD(P) binding site [chemical binding]; other site 264198001242 trimer interface B [polypeptide binding]; other site 264198001243 trimer interface A [polypeptide binding]; other site 264198001244 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198001245 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198001246 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198001247 short chain dehydrogenase; Provisional; Region: PRK06949 264198001248 classical (c) SDRs; Region: SDR_c; cd05233 264198001249 NAD(P) binding site [chemical binding]; other site 264198001250 active site 264198001251 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001252 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198001253 active site 264198001254 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198001255 Phosphotransferase enzyme family; Region: APH; pfam01636 264198001256 putative active site [active] 264198001257 putative substrate binding site [chemical binding]; other site 264198001258 ATP binding site [chemical binding]; other site 264198001259 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198001260 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198001261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001262 active site 264198001263 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198001264 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264198001265 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198001266 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198001267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198001270 dimerization interface [polypeptide binding]; other site 264198001271 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 264198001272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198001273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001274 putative substrate translocation pore; other site 264198001275 choline dehydrogenase; Validated; Region: PRK02106 264198001276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198001277 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198001278 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198001279 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264198001280 NAD(P) binding site [chemical binding]; other site 264198001281 catalytic residues [active] 264198001282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264198001283 Transposase; Region: HTH_Tnp_1; pfam01527 264198001284 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 264198001285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264198001286 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264198001287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 264198001288 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 264198001289 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 264198001290 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264198001291 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198001292 H-NS histone family; Region: Histone_HNS; pfam00816 264198001293 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 264198001294 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198001295 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198001296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198001298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198001300 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 264198001301 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264198001302 homotrimer interaction site [polypeptide binding]; other site 264198001303 putative active site [active] 264198001304 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198001305 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 264198001306 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198001307 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198001308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001309 NAD(P) binding site [chemical binding]; other site 264198001310 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198001311 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198001312 acyl-activating enzyme (AAE) consensus motif; other site 264198001313 putative AMP binding site [chemical binding]; other site 264198001314 putative active site [active] 264198001315 putative CoA binding site [chemical binding]; other site 264198001316 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 264198001317 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198001318 active site 264198001319 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264198001320 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198001321 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 264198001322 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264198001323 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198001324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001325 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198001326 active site 264198001327 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 264198001328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198001329 Cytochrome c553 [Energy production and conversion]; Region: COG2863 264198001330 Cytochrome c; Region: Cytochrom_C; cl11414 264198001331 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198001332 classical (c) SDRs; Region: SDR_c; cd05233 264198001333 NAD(P) binding site [chemical binding]; other site 264198001334 active site 264198001335 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264198001336 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198001337 homotetramer interface [polypeptide binding]; other site 264198001338 NAD(P) binding site [chemical binding]; other site 264198001339 homodimer interface [polypeptide binding]; other site 264198001340 active site 264198001341 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198001342 Phosphotransferase enzyme family; Region: APH; pfam01636 264198001343 putative active site [active] 264198001344 putative substrate binding site [chemical binding]; other site 264198001345 ATP binding site [chemical binding]; other site 264198001346 short chain dehydrogenase; Provisional; Region: PRK07035 264198001347 classical (c) SDRs; Region: SDR_c; cd05233 264198001348 NAD(P) binding site [chemical binding]; other site 264198001349 active site 264198001350 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198001351 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198001352 ligand binding site [chemical binding]; other site 264198001353 homodimer interface [polypeptide binding]; other site 264198001354 NAD(P) binding site [chemical binding]; other site 264198001355 trimer interface B [polypeptide binding]; other site 264198001356 trimer interface A [polypeptide binding]; other site 264198001357 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198001358 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198001359 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198001360 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264198001361 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198001362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198001363 PAS domain; Region: PAS_9; pfam13426 264198001364 putative active site [active] 264198001365 heme pocket [chemical binding]; other site 264198001366 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198001367 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264198001368 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264198001369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198001370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198001371 dimer interface [polypeptide binding]; other site 264198001372 phosphorylation site [posttranslational modification] 264198001373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198001374 ATP binding site [chemical binding]; other site 264198001375 Mg2+ binding site [ion binding]; other site 264198001376 G-X-G motif; other site 264198001377 Response regulator receiver domain; Region: Response_reg; pfam00072 264198001378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001379 active site 264198001380 phosphorylation site [posttranslational modification] 264198001381 intermolecular recognition site; other site 264198001382 dimerization interface [polypeptide binding]; other site 264198001383 Response regulator receiver domain; Region: Response_reg; pfam00072 264198001384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001385 active site 264198001386 phosphorylation site [posttranslational modification] 264198001387 intermolecular recognition site; other site 264198001388 dimerization interface [polypeptide binding]; other site 264198001389 Heme NO binding associated; Region: HNOBA; pfam07701 264198001390 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 264198001391 cyclase homology domain; Region: CHD; cd07302 264198001392 nucleotidyl binding site; other site 264198001393 metal binding site [ion binding]; metal-binding site 264198001394 dimer interface [polypeptide binding]; other site 264198001395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264198001396 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264198001397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198001398 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198001399 Walker A motif; other site 264198001400 ATP binding site [chemical binding]; other site 264198001401 Walker B motif; other site 264198001402 arginine finger; other site 264198001403 Helix-turn-helix domain; Region: HTH_38; pfam13936 264198001404 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 264198001405 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 264198001406 active site 264198001407 catalytic triad [active] 264198001408 Zeta toxin; Region: Zeta_toxin; pfam06414 264198001409 acyl-CoA synthetase; Validated; Region: PRK08162 264198001410 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 264198001411 acyl-activating enzyme (AAE) consensus motif; other site 264198001412 putative active site [active] 264198001413 AMP binding site [chemical binding]; other site 264198001414 putative CoA binding site [chemical binding]; other site 264198001415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001417 active site 264198001418 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198001419 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 264198001420 putative active site [active] 264198001421 metal binding site [ion binding]; metal-binding site 264198001422 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 264198001423 Coenzyme A transferase; Region: CoA_trans; smart00882 264198001424 Coenzyme A transferase; Region: CoA_trans; cl17247 264198001425 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 264198001426 dimer interaction site [polypeptide binding]; other site 264198001427 substrate-binding tunnel; other site 264198001428 active site 264198001429 catalytic site [active] 264198001430 substrate binding site [chemical binding]; other site 264198001431 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198001432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001433 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198001434 dimerization interface [polypeptide binding]; other site 264198001435 substrate binding pocket [chemical binding]; other site 264198001436 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 264198001437 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 264198001438 dimer interface [polypeptide binding]; other site 264198001439 NADP binding site [chemical binding]; other site 264198001440 catalytic residues [active] 264198001441 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198001442 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198001443 putative ligand binding site [chemical binding]; other site 264198001444 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198001445 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198001446 TM-ABC transporter signature motif; other site 264198001447 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198001448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198001449 TM-ABC transporter signature motif; other site 264198001450 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 264198001451 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198001452 Walker A/P-loop; other site 264198001453 ATP binding site [chemical binding]; other site 264198001454 Q-loop/lid; other site 264198001455 ABC transporter signature motif; other site 264198001456 Walker B; other site 264198001457 D-loop; other site 264198001458 H-loop/switch region; other site 264198001459 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198001460 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198001461 Walker A/P-loop; other site 264198001462 ATP binding site [chemical binding]; other site 264198001463 Q-loop/lid; other site 264198001464 ABC transporter signature motif; other site 264198001465 Walker B; other site 264198001466 D-loop; other site 264198001467 H-loop/switch region; other site 264198001468 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 264198001469 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 264198001470 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264198001471 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264198001472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001473 putative substrate translocation pore; other site 264198001474 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198001475 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264198001476 ParB-like nuclease domain; Region: ParB; smart00470 264198001477 KorB domain; Region: KorB; pfam08535 264198001478 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613 264198001479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198001480 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 264198001481 P-loop; other site 264198001482 Magnesium ion binding site [ion binding]; other site 264198001483 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198001484 Magnesium ion binding site [ion binding]; other site 264198001485 Protein of unknown function (DUF2761); Region: DUF2761; pfam10959 264198001486 Antirestriction protein; Region: Antirestrict; pfam03230 264198001487 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 264198001488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 264198001489 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264198001490 Phage integrase protein; Region: DUF3701; pfam12482 264198001491 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264198001492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198001493 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 264198001494 Int/Topo IB signature motif; other site 264198001495 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 264198001496 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 264198001497 FAD binding domain; Region: FAD_binding_3; pfam01494 264198001498 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198001499 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198001500 active site 264198001501 dimer interface [polypeptide binding]; other site 264198001502 metal binding site [ion binding]; metal-binding site 264198001503 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001504 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198001505 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198001506 octamer interface [polypeptide binding]; other site 264198001507 active site 264198001508 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 264198001509 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198001510 dimer interface [polypeptide binding]; other site 264198001511 active site 264198001512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198001514 dimerization interface [polypeptide binding]; other site 264198001515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198001516 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264198001517 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264198001518 benzoate transport; Region: 2A0115; TIGR00895 264198001519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001520 putative substrate translocation pore; other site 264198001521 FAD binding domain; Region: FAD_binding_3; pfam01494 264198001522 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198001523 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198001524 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198001525 active site 264198001526 dimer interface [polypeptide binding]; other site 264198001527 metal binding site [ion binding]; metal-binding site 264198001528 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001529 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 264198001530 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198001531 dimer interface [polypeptide binding]; other site 264198001532 active site 264198001533 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198001534 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198001535 octamer interface [polypeptide binding]; other site 264198001536 active site 264198001537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001539 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 264198001540 dimerization interface [polypeptide binding]; other site 264198001541 putative substrate binding pocket [chemical binding]; other site 264198001542 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198001543 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198001544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198001545 substrate binding site [chemical binding]; other site 264198001546 oxyanion hole (OAH) forming residues; other site 264198001547 trimer interface [polypeptide binding]; other site 264198001548 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198001549 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198001550 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198001551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001553 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 264198001554 dimerization interface [polypeptide binding]; other site 264198001555 putative substrate binding pocket [chemical binding]; other site 264198001556 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198001557 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 264198001558 active site 264198001559 iron coordination sites [ion binding]; other site 264198001560 substrate binding pocket [chemical binding]; other site 264198001561 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 264198001562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198001563 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198001564 acyl-activating enzyme (AAE) consensus motif; other site 264198001565 acyl-activating enzyme (AAE) consensus motif; other site 264198001566 putative AMP binding site [chemical binding]; other site 264198001567 putative active site [active] 264198001568 putative CoA binding site [chemical binding]; other site 264198001569 thiolase; Provisional; Region: PRK06158 264198001570 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198001571 active site 264198001572 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198001573 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198001574 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198001575 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198001576 iron-sulfur cluster [ion binding]; other site 264198001577 [2Fe-2S] cluster binding site [ion binding]; other site 264198001578 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198001579 hydrophobic ligand binding site; other site 264198001580 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198001581 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198001582 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198001583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198001585 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198001586 classical (c) SDRs; Region: SDR_c; cd05233 264198001587 NAD(P) binding site [chemical binding]; other site 264198001588 active site 264198001589 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198001590 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 264198001591 putative ligand binding site [chemical binding]; other site 264198001592 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198001593 TM-ABC transporter signature motif; other site 264198001594 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198001595 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198001596 TM-ABC transporter signature motif; other site 264198001597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198001598 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198001599 Walker A/P-loop; other site 264198001600 ATP binding site [chemical binding]; other site 264198001601 Q-loop/lid; other site 264198001602 ABC transporter signature motif; other site 264198001603 Walker B; other site 264198001604 D-loop; other site 264198001605 H-loop/switch region; other site 264198001606 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 264198001607 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 264198001608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198001609 putative mercury resistance protein; Provisional; Region: PRK13747 264198001610 transcriptional regulator MerD; Provisional; Region: PRK13749 264198001611 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 264198001612 DNA binding residues [nucleotide binding] 264198001613 putative dimer interface [polypeptide binding]; other site 264198001614 putative mercuric reductase; Provisional; Region: PRK13748 264198001615 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198001616 metal-binding site [ion binding] 264198001617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198001618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198001619 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198001620 metal-binding site [ion binding] 264198001621 putative mercuric transport protein; Provisional; Region: PRK13751 264198001622 putative transcriptional regulator MerR; Provisional; Region: PRK13752 264198001623 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 264198001624 DNA binding residues [nucleotide binding] 264198001625 dimer interface [polypeptide binding]; other site 264198001626 mercury binding site [ion binding]; other site 264198001627 TrfA protein; Region: TrfA; pfam07042 264198001628 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264198001629 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264198001630 dimer interface [polypeptide binding]; other site 264198001631 ssDNA binding site [nucleotide binding]; other site 264198001632 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264198001633 conjugal transfer protein TrbA; Provisional; Region: PRK13890 264198001634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198001635 salt bridge; other site 264198001636 non-specific DNA binding site [nucleotide binding]; other site 264198001637 sequence-specific DNA binding site [nucleotide binding]; other site 264198001638 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 264198001639 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264198001640 ATP binding site [chemical binding]; other site 264198001641 Walker A motif; other site 264198001642 hexamer interface [polypeptide binding]; other site 264198001643 Walker B motif; other site 264198001644 conjugal transfer protein TrbC; Provisional; Region: PRK13892 264198001645 conjugal transfer protein TrbD; Provisional; Region: PRK13823 264198001646 conjugal transfer protein TrbE; Provisional; Region: PRK13891 264198001647 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 264198001648 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264198001649 Walker A motif; other site 264198001650 ATP binding site [chemical binding]; other site 264198001651 Walker B motif; other site 264198001652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198001653 Walker B; other site 264198001654 D-loop; other site 264198001655 H-loop/switch region; other site 264198001656 conjugal transfer protein TrbF; Provisional; Region: PRK13887 264198001657 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 264198001658 VirB7 interaction site; other site 264198001659 conjugal transfer protein TrbH; Provisional; Region: PRK13883 264198001660 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 264198001661 conjugal transfer protein TrbI; Provisional; Region: PRK13881 264198001662 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 264198001663 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 264198001664 entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359 264198001665 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 264198001666 conjugal transfer protein TrbM; Provisional; Region: PRK13893 264198001667 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198001668 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198001669 catalytic residue [active] 264198001670 conjugal transfer protein TrbP; Provisional; Region: PRK13882 264198001671 TraX protein; Region: TraX; pfam05857 264198001672 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264198001673 ligand binding site [chemical binding]; other site 264198001674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198001675 S-adenosylmethionine binding site [chemical binding]; other site 264198001676 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 264198001677 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264198001678 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 264198001679 catalytic residues [active] 264198001680 catalytic nucleophile [active] 264198001681 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 264198001682 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 264198001683 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 264198001684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 264198001685 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 264198001686 active site 264198001687 metal binding site [ion binding]; metal-binding site 264198001688 interdomain interaction site; other site 264198001689 DNA topoisomerase III; Provisional; Region: PRK07726 264198001690 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264198001691 active site 264198001692 putative interdomain interaction site [polypeptide binding]; other site 264198001693 putative metal-binding site [ion binding]; other site 264198001694 putative nucleotide binding site [chemical binding]; other site 264198001695 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264198001696 domain I; other site 264198001697 DNA binding groove [nucleotide binding] 264198001698 phosphate binding site [ion binding]; other site 264198001699 domain II; other site 264198001700 domain III; other site 264198001701 nucleotide binding site [chemical binding]; other site 264198001702 catalytic site [active] 264198001703 domain IV; other site 264198001704 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264198001705 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 264198001706 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 264198001707 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 264198001708 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264198001709 Walker A motif; other site 264198001710 ATP binding site [chemical binding]; other site 264198001711 Walker B motif; other site 264198001712 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 264198001713 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 264198001714 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 264198001715 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 264198001716 P-loop; other site 264198001717 conjugal transfer protein TraM; Provisional; Region: PRK13895 264198001718 DnaA N-terminal domain; Region: DnaA_N; pfam11638 264198001719 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 264198001720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198001721 Walker A motif; other site 264198001722 ATP binding site [chemical binding]; other site 264198001723 Walker B motif; other site 264198001724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264198001725 arginine finger; other site 264198001726 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264198001727 DnaA box-binding interface [nucleotide binding]; other site 264198001728 DNA polymerase III subunit beta; Validated; Region: PRK05643 264198001729 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264198001730 putative DNA binding surface [nucleotide binding]; other site 264198001731 dimer interface [polypeptide binding]; other site 264198001732 beta-clamp/clamp loader binding surface; other site 264198001733 beta-clamp/translesion DNA polymerase binding surface; other site 264198001734 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 264198001735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198001736 ATP binding site [chemical binding]; other site 264198001737 Mg2+ binding site [ion binding]; other site 264198001738 G-X-G motif; other site 264198001739 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264198001740 anchoring element; other site 264198001741 dimer interface [polypeptide binding]; other site 264198001742 ATP binding site [chemical binding]; other site 264198001743 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264198001744 active site 264198001745 putative metal-binding site [ion binding]; other site 264198001746 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264198001747 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264198001748 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 264198001749 putative active site [active] 264198001750 putative NTP binding site [chemical binding]; other site 264198001751 putative nucleic acid binding site [nucleotide binding]; other site 264198001752 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 264198001753 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 264198001754 active site 264198001755 Protein of unknown function (DUF1484); Region: DUF1484; pfam07363 264198001756 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198001757 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198001758 active site 264198001759 catalytic tetrad [active] 264198001760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001762 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 264198001763 putative effector binding pocket; other site 264198001764 putative dimerization interface [polypeptide binding]; other site 264198001765 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 264198001766 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264198001767 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264198001768 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 264198001769 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 264198001770 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264198001771 PAAR motif; Region: PAAR_motif; pfam05488 264198001772 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 264198001773 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 264198001774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 264198001775 FOG: CBS domain [General function prediction only]; Region: COG0517 264198001776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 264198001777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198001778 PAS domain; Region: PAS_9; pfam13426 264198001779 putative active site [active] 264198001780 heme pocket [chemical binding]; other site 264198001781 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198001782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198001783 metal binding site [ion binding]; metal-binding site 264198001784 active site 264198001785 I-site; other site 264198001786 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198001787 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198001788 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198001789 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198001790 Uncharacterized conserved protein [Function unknown]; Region: COG1434 264198001791 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 264198001792 putative active site [active] 264198001793 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198001794 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198001795 ligand binding site [chemical binding]; other site 264198001796 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264198001797 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 264198001798 potential catalytic triad [active] 264198001799 conserved cys residue [active] 264198001800 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 264198001801 DNA binding residues [nucleotide binding] 264198001802 dimerization interface [polypeptide binding]; other site 264198001803 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 264198001804 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 264198001805 homodimer interface [polypeptide binding]; other site 264198001806 chemical substrate binding site [chemical binding]; other site 264198001807 oligomer interface [polypeptide binding]; other site 264198001808 metal binding site [ion binding]; metal-binding site 264198001809 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 264198001810 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 264198001811 active site 264198001812 zinc binding site [ion binding]; other site 264198001813 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264198001814 active site 264198001815 homotetramer interface [polypeptide binding]; other site 264198001816 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264198001817 active site 264198001818 homotetramer interface [polypeptide binding]; other site 264198001819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001820 D-galactonate transporter; Region: 2A0114; TIGR00893 264198001821 putative substrate translocation pore; other site 264198001822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198001825 dimerization interface [polypeptide binding]; other site 264198001826 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 264198001827 Cache domain; Region: Cache_1; pfam02743 264198001828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198001829 dimerization interface [polypeptide binding]; other site 264198001830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198001831 dimer interface [polypeptide binding]; other site 264198001832 putative CheW interface [polypeptide binding]; other site 264198001833 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 264198001834 Protein of unknown function DUF72; Region: DUF72; pfam01904 264198001835 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 264198001836 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198001837 ATP binding site [chemical binding]; other site 264198001838 Mg++ binding site [ion binding]; other site 264198001839 motif III; other site 264198001840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198001841 nucleotide binding region [chemical binding]; other site 264198001842 ATP-binding site [chemical binding]; other site 264198001843 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 264198001844 putative RNA binding site [nucleotide binding]; other site 264198001845 FOG: CBS domain [General function prediction only]; Region: COG0517 264198001846 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 264198001847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001848 putative substrate translocation pore; other site 264198001849 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264198001850 catalytic residues [active] 264198001851 dimer interface [polypeptide binding]; other site 264198001852 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 264198001853 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198001854 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198001855 dihydropyrimidinase; Provisional; Region: PRK13404 264198001856 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 264198001857 tetramer interface [polypeptide binding]; other site 264198001858 active site 264198001859 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198001860 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198001861 Beta-lactamase; Region: Beta-lactamase; pfam00144 264198001862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001863 D-galactonate transporter; Region: 2A0114; TIGR00893 264198001864 putative substrate translocation pore; other site 264198001865 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198001866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198001867 DNA-binding site [nucleotide binding]; DNA binding site 264198001868 FCD domain; Region: FCD; pfam07729 264198001869 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198001870 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198001871 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198001872 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198001873 metal binding site [ion binding]; metal-binding site 264198001874 putative dimer interface [polypeptide binding]; other site 264198001875 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264198001876 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198001877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198001878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198001880 putative substrate translocation pore; other site 264198001881 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198001882 GAF domain; Region: GAF; pfam01590 264198001883 Hemerythrin-like domain of FBXL5-like proteins; Region: Hr_FBXL5; cd12109 264198001884 Fe binding site [ion binding]; other site 264198001885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198001886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198001887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001888 active site 264198001889 phosphorylation site [posttranslational modification] 264198001890 intermolecular recognition site; other site 264198001891 dimerization interface [polypeptide binding]; other site 264198001892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198001893 DNA binding site [nucleotide binding] 264198001894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198001895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001896 active site 264198001897 phosphorylation site [posttranslational modification] 264198001898 intermolecular recognition site; other site 264198001899 dimerization interface [polypeptide binding]; other site 264198001900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198001901 DNA binding site [nucleotide binding] 264198001902 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198001903 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198001904 trimer interface [polypeptide binding]; other site 264198001905 eyelet of channel; other site 264198001906 cell division topological specificity factor MinE; Provisional; Region: PRK13989 264198001907 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 264198001908 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 264198001909 Switch I; other site 264198001910 Switch II; other site 264198001911 septum formation inhibitor; Reviewed; Region: PRK01973 264198001912 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 264198001913 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264198001914 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 264198001915 oligomer interface [polypeptide binding]; other site 264198001916 metal binding site [ion binding]; metal-binding site 264198001917 metal binding site [ion binding]; metal-binding site 264198001918 putative Cl binding site [ion binding]; other site 264198001919 basic sphincter; other site 264198001920 hydrophobic gate; other site 264198001921 periplasmic entrance; other site 264198001922 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264198001923 Sel1-like repeats; Region: SEL1; smart00671 264198001924 Sel1-like repeats; Region: SEL1; smart00671 264198001925 Sel1-like repeats; Region: SEL1; smart00671 264198001926 Sel1 repeat; Region: Sel1; cl02723 264198001927 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264198001928 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198001929 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264198001930 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 264198001931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 264198001932 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 264198001933 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 264198001934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 264198001935 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264198001936 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198001937 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264198001938 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 264198001939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 264198001940 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264198001941 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264198001942 GatB domain; Region: GatB_Yqey; smart00845 264198001943 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198001944 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198001945 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264198001946 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 264198001947 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 264198001948 rod shape-determining protein MreB; Provisional; Region: PRK13927 264198001949 MreB and similar proteins; Region: MreB_like; cd10225 264198001950 nucleotide binding site [chemical binding]; other site 264198001951 Mg binding site [ion binding]; other site 264198001952 putative protofilament interaction site [polypeptide binding]; other site 264198001953 RodZ interaction site [polypeptide binding]; other site 264198001954 rod shape-determining protein MreC; Provisional; Region: PRK13922 264198001955 rod shape-determining protein MreC; Region: MreC; pfam04085 264198001956 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 264198001957 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264198001958 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264198001959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264198001960 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 264198001961 Protein of unknown function, DUF484; Region: DUF484; cl17449 264198001962 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264198001963 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198001964 active site 264198001965 DNA binding site [nucleotide binding] 264198001966 Int/Topo IB signature motif; other site 264198001967 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198001968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198001969 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198001970 dimerization interface [polypeptide binding]; other site 264198001971 substrate binding pocket [chemical binding]; other site 264198001972 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198001973 lipoate-protein ligase B; Provisional; Region: PRK14343 264198001974 lipoyl synthase; Provisional; Region: PRK05481 264198001975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198001976 FeS/SAM binding site; other site 264198001977 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 264198001978 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 264198001979 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 264198001980 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 264198001981 putative active site [active] 264198001982 Predicted membrane protein [Function unknown]; Region: COG3819 264198001983 Predicted membrane protein [Function unknown]; Region: COG3817 264198001984 Protein of unknown function (DUF979); Region: DUF979; pfam06166 264198001985 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 264198001986 putative substrate binding pocket [chemical binding]; other site 264198001987 AC domain interface; other site 264198001988 catalytic triad [active] 264198001989 AB domain interface; other site 264198001990 interchain disulfide; other site 264198001991 haemagglutination activity domain; Region: Haemagg_act; pfam05860 264198001992 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 264198001993 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 264198001994 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 264198001995 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 264198001996 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 264198001997 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 264198001998 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 264198001999 cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843 264198002000 CAAX protease self-immunity; Region: Abi; cl00558 264198002001 Predicted integral membrane protein [Function unknown]; Region: COG5652 264198002002 Protein of unknown function (DUF330); Region: DUF330; cl01135 264198002003 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 264198002004 mce related protein; Region: MCE; pfam02470 264198002005 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264198002006 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264198002007 Walker A/P-loop; other site 264198002008 ATP binding site [chemical binding]; other site 264198002009 Q-loop/lid; other site 264198002010 ABC transporter signature motif; other site 264198002011 Walker B; other site 264198002012 D-loop; other site 264198002013 H-loop/switch region; other site 264198002014 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264198002015 Permease; Region: Permease; pfam02405 264198002016 biotin--protein ligase; Provisional; Region: PRK06955 264198002017 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 264198002018 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 264198002019 pantothenate kinase; Reviewed; Region: PRK13328 264198002020 Sporulation related domain; Region: SPOR; pfam05036 264198002021 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 264198002022 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 264198002023 active site 264198002024 nucleotide binding site [chemical binding]; other site 264198002025 HIGH motif; other site 264198002026 KMSKS motif; other site 264198002027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198002028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198002029 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198002030 dinuclear metal binding motif [ion binding]; other site 264198002031 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198002032 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198002033 active site 264198002034 nucleophile elbow; other site 264198002035 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198002036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198002037 substrate binding site [chemical binding]; other site 264198002038 oxyanion hole (OAH) forming residues; other site 264198002039 trimer interface [polypeptide binding]; other site 264198002040 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198002041 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198002042 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198002043 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198002044 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198002045 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198002046 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 264198002047 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264198002048 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 264198002049 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 264198002050 active site residue [active] 264198002051 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 264198002052 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 264198002053 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264198002054 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 264198002055 substrate binding pocket [chemical binding]; other site 264198002056 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 264198002057 B12 binding site [chemical binding]; other site 264198002058 cobalt ligand [ion binding]; other site 264198002059 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 264198002060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198002061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002062 active site 264198002063 phosphorylation site [posttranslational modification] 264198002064 intermolecular recognition site; other site 264198002065 dimerization interface [polypeptide binding]; other site 264198002066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198002067 DNA binding residues [nucleotide binding] 264198002068 dimerization interface [polypeptide binding]; other site 264198002069 Response regulator receiver domain; Region: Response_reg; pfam00072 264198002070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002071 active site 264198002072 phosphorylation site [posttranslational modification] 264198002073 intermolecular recognition site; other site 264198002074 dimerization interface [polypeptide binding]; other site 264198002075 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 264198002076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198002077 Histidine kinase; Region: HisKA_3; pfam07730 264198002078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002079 ATP binding site [chemical binding]; other site 264198002080 Mg2+ binding site [ion binding]; other site 264198002081 G-X-G motif; other site 264198002082 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 264198002083 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 264198002084 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 264198002085 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 264198002086 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264198002087 active site 264198002088 HIGH motif; other site 264198002089 KMSK motif region; other site 264198002090 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264198002091 tRNA binding surface [nucleotide binding]; other site 264198002092 anticodon binding site; other site 264198002093 Sporulation related domain; Region: SPOR; pfam05036 264198002094 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 264198002095 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 264198002096 catalytic residues [active] 264198002097 hinge region; other site 264198002098 alpha helical domain; other site 264198002099 short chain dehydrogenase; Provisional; Region: PRK07024 264198002100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002101 NAD(P) binding site [chemical binding]; other site 264198002102 active site 264198002103 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264198002104 intersubunit interface [polypeptide binding]; other site 264198002105 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198002106 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264198002107 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 264198002108 DNA binding residues [nucleotide binding] 264198002109 putative dimer interface [polypeptide binding]; other site 264198002110 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198002111 CoenzymeA binding site [chemical binding]; other site 264198002112 subunit interaction site [polypeptide binding]; other site 264198002113 PHB binding site; other site 264198002114 isovaleryl-CoA dehydrogenase; Region: PLN02519 264198002115 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 264198002116 substrate binding site [chemical binding]; other site 264198002117 FAD binding site [chemical binding]; other site 264198002118 catalytic base [active] 264198002119 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 264198002120 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 264198002121 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 264198002122 active site clefts [active] 264198002123 zinc binding site [ion binding]; other site 264198002124 dimer interface [polypeptide binding]; other site 264198002125 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264198002126 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198002127 dimer interface [polypeptide binding]; other site 264198002128 active site 264198002129 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 264198002130 C factor cell-cell signaling protein; Provisional; Region: PRK09009 264198002131 NADP binding site [chemical binding]; other site 264198002132 homodimer interface [polypeptide binding]; other site 264198002133 active site 264198002134 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198002135 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198002136 active site 264198002137 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198002138 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198002139 putative catalytic residue [active] 264198002140 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 264198002141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198002142 motif II; other site 264198002143 hypothetical protein; Provisional; Region: PRK01842 264198002144 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 264198002145 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198002146 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 264198002147 putative C-terminal domain interface [polypeptide binding]; other site 264198002148 putative GSH binding site (G-site) [chemical binding]; other site 264198002149 putative dimer interface [polypeptide binding]; other site 264198002150 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264198002151 N-terminal domain interface [polypeptide binding]; other site 264198002152 dimer interface [polypeptide binding]; other site 264198002153 substrate binding pocket (H-site) [chemical binding]; other site 264198002154 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264198002155 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264198002156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198002157 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198002158 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 264198002159 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198002160 inhibitor-cofactor binding pocket; inhibition site 264198002161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002162 catalytic residue [active] 264198002163 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 264198002164 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 264198002165 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198002166 catalytic residue [active] 264198002167 AAA domain; Region: AAA_26; pfam13500 264198002168 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 264198002169 biotin synthase; Region: bioB; TIGR00433 264198002170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198002171 FeS/SAM binding site; other site 264198002172 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 264198002173 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264198002174 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198002175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198002176 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198002177 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198002178 carboxyltransferase (CT) interaction site; other site 264198002179 biotinylation site [posttranslational modification]; other site 264198002180 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 264198002181 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 264198002182 putative ligand binding site [chemical binding]; other site 264198002183 NAD binding site [chemical binding]; other site 264198002184 dimerization interface [polypeptide binding]; other site 264198002185 catalytic site [active] 264198002186 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 264198002187 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198002188 active site 264198002189 catalytic residues [active] 264198002190 metal binding site [ion binding]; metal-binding site 264198002191 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 264198002192 putative deacylase active site [active] 264198002193 Predicted thioesterase [General function prediction only]; Region: COG5496 264198002194 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 264198002195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198002196 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198002197 MULE transposase domain; Region: MULE; pfam10551 264198002198 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264198002199 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198002200 N-terminal plug; other site 264198002201 ligand-binding site [chemical binding]; other site 264198002202 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198002203 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198002204 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 264198002205 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 264198002206 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198002207 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 264198002208 P-loop, Walker A motif; other site 264198002209 Base recognition motif; other site 264198002210 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 264198002211 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264198002212 metal binding site 2 [ion binding]; metal-binding site 264198002213 putative DNA binding helix; other site 264198002214 metal binding site 1 [ion binding]; metal-binding site 264198002215 dimer interface [polypeptide binding]; other site 264198002216 structural Zn2+ binding site [ion binding]; other site 264198002217 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 264198002218 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198002219 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 264198002220 active site 264198002221 HslU subunit interaction site [polypeptide binding]; other site 264198002222 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 264198002223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002224 Walker A motif; other site 264198002225 ATP binding site [chemical binding]; other site 264198002226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002227 Walker B motif; other site 264198002228 arginine finger; other site 264198002229 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264198002230 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 264198002231 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 264198002232 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 264198002233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002234 active site 264198002235 phosphorylation site [posttranslational modification] 264198002236 intermolecular recognition site; other site 264198002237 dimerization interface [polypeptide binding]; other site 264198002238 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198002239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002241 ATP binding site [chemical binding]; other site 264198002242 Mg2+ binding site [ion binding]; other site 264198002243 G-X-G motif; other site 264198002244 Protein of unknown function (DUF461); Region: DUF461; pfam04314 264198002245 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198002246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198002247 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 264198002248 putative substrate binding pocket [chemical binding]; other site 264198002249 putative dimerization interface [polypeptide binding]; other site 264198002250 Protein of unknown function, DUF606; Region: DUF606; pfam04657 264198002251 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 264198002252 Putative zinc-finger; Region: zf-HC2; pfam13490 264198002253 RNA polymerase sigma factor; Provisional; Region: PRK12520 264198002254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198002255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198002256 DNA binding residues [nucleotide binding] 264198002257 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 264198002258 homohexameric interface [polypeptide binding]; other site 264198002259 feedback inhibition sensing region; other site 264198002260 nucleotide binding site [chemical binding]; other site 264198002261 N-acetyl-L-glutamate binding site [chemical binding]; other site 264198002262 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 264198002263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264198002264 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 264198002265 division inhibitor protein; Provisional; Region: slmA; PRK09480 264198002266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198002267 inner membrane protein; Provisional; Region: PRK11715 264198002268 sensory histidine kinase CreC; Provisional; Region: PRK11100 264198002269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198002270 dimerization interface [polypeptide binding]; other site 264198002271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198002272 dimer interface [polypeptide binding]; other site 264198002273 phosphorylation site [posttranslational modification] 264198002274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002275 ATP binding site [chemical binding]; other site 264198002276 Mg2+ binding site [ion binding]; other site 264198002277 G-X-G motif; other site 264198002278 DNA-binding response regulator CreB; Provisional; Region: PRK11083 264198002279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002280 active site 264198002281 phosphorylation site [posttranslational modification] 264198002282 intermolecular recognition site; other site 264198002283 dimerization interface [polypeptide binding]; other site 264198002284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198002285 DNA binding site [nucleotide binding] 264198002286 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 264198002287 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 264198002288 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264198002289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002290 S-adenosylmethionine binding site [chemical binding]; other site 264198002291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198002292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198002293 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198002294 putative effector binding pocket; other site 264198002295 dimerization interface [polypeptide binding]; other site 264198002296 EamA-like transporter family; Region: EamA; pfam00892 264198002297 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 264198002298 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198002299 active site 2 [active] 264198002300 active site 1 [active] 264198002301 muropeptide transporter; Reviewed; Region: ampG; PRK11902 264198002302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002303 putative substrate translocation pore; other site 264198002304 Peptidase family M48; Region: Peptidase_M48; pfam01435 264198002305 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 264198002306 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264198002307 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 264198002308 putative active site [active] 264198002309 putative catalytic site [active] 264198002310 putative DNA binding site [nucleotide binding]; other site 264198002311 putative phosphate binding site [ion binding]; other site 264198002312 metal binding site A [ion binding]; metal-binding site 264198002313 putative AP binding site [nucleotide binding]; other site 264198002314 putative metal binding site B [ion binding]; other site 264198002315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002316 active site 264198002317 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198002318 nucleophile elbow; other site 264198002319 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198002320 Patatin phospholipase; Region: DUF3734; pfam12536 264198002321 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 264198002322 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264198002323 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264198002324 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264198002325 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264198002326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198002327 putative acyl-acceptor binding pocket; other site 264198002328 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198002329 putative acyl-acceptor binding pocket; other site 264198002330 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264198002331 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264198002332 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264198002333 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264198002334 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 264198002335 choline dehydrogenase; Validated; Region: PRK02106 264198002336 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198002337 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 264198002338 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198002339 active site 264198002340 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 264198002341 ThiC-associated domain; Region: ThiC-associated; pfam13667 264198002342 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 264198002343 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 264198002344 sulfur carrier protein ThiS; Provisional; Region: PRK06944 264198002345 hydrophobic patch; other site 264198002346 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 264198002347 ThiS interaction site; other site 264198002348 putative active site [active] 264198002349 tetramer interface [polypeptide binding]; other site 264198002350 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264198002351 thiamine phosphate binding site [chemical binding]; other site 264198002352 active site 264198002353 pyrophosphate binding site [ion binding]; other site 264198002354 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198002355 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 264198002356 CoenzymeA binding site [chemical binding]; other site 264198002357 subunit interaction site [polypeptide binding]; other site 264198002358 PHB binding site; other site 264198002359 PGDYG protein; Region: PGDYG; pfam14083 264198002360 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 264198002361 dimer interface [polypeptide binding]; other site 264198002362 substrate binding site [chemical binding]; other site 264198002363 ATP binding site [chemical binding]; other site 264198002364 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 264198002365 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 264198002366 homotetramer interface [polypeptide binding]; other site 264198002367 ligand binding site [chemical binding]; other site 264198002368 catalytic site [active] 264198002369 NAD binding site [chemical binding]; other site 264198002370 Membrane protein of unknown function; Region: DUF360; pfam04020 264198002371 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 264198002372 FAD binding site [chemical binding]; other site 264198002373 TfoX N-terminal domain; Region: TfoX_N; pfam04993 264198002374 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 264198002375 Uncharacterized conserved protein [Function unknown]; Region: COG1656 264198002376 Protein of unknown function DUF82; Region: DUF82; pfam01927 264198002377 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 264198002378 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198002379 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198002380 catalytic residue [active] 264198002381 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 264198002382 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 264198002383 putative NAD(P) binding site [chemical binding]; other site 264198002384 active site 264198002385 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 264198002386 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198002387 putative C-terminal domain interface [polypeptide binding]; other site 264198002388 putative GSH binding site (G-site) [chemical binding]; other site 264198002389 putative dimer interface [polypeptide binding]; other site 264198002390 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 264198002391 putative N-terminal domain interface [polypeptide binding]; other site 264198002392 putative dimer interface [polypeptide binding]; other site 264198002393 putative substrate binding pocket (H-site) [chemical binding]; other site 264198002394 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 264198002395 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264198002396 metal binding triad [ion binding]; metal-binding site 264198002397 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264198002398 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198002399 Zn2+ binding site [ion binding]; other site 264198002400 Mg2+ binding site [ion binding]; other site 264198002401 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 264198002402 Uncharacterized conserved protein [Function unknown]; Region: COG1565 264198002403 short chain dehydrogenase; Provisional; Region: PRK09134 264198002404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002405 NAD(P) binding site [chemical binding]; other site 264198002406 active site 264198002407 Dihydroneopterin aldolase; Region: FolB; smart00905 264198002408 active site 264198002409 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 264198002410 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 264198002411 Ligand Binding Site [chemical binding]; other site 264198002412 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 264198002413 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 264198002414 Substrate binding site; other site 264198002415 Mg++ binding site; other site 264198002416 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 264198002417 active site 264198002418 substrate binding site [chemical binding]; other site 264198002419 CoA binding site [chemical binding]; other site 264198002420 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264198002421 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264198002422 glutaminase active site [active] 264198002423 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264198002424 dimer interface [polypeptide binding]; other site 264198002425 active site 264198002426 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264198002427 dimer interface [polypeptide binding]; other site 264198002428 active site 264198002429 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264198002430 Predicted transporter component [General function prediction only]; Region: COG2391 264198002431 Sulphur transport; Region: Sulf_transp; pfam04143 264198002432 Predicted transporter component [General function prediction only]; Region: COG2391 264198002433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198002434 dimerization interface [polypeptide binding]; other site 264198002435 putative DNA binding site [nucleotide binding]; other site 264198002436 putative Zn2+ binding site [ion binding]; other site 264198002437 Predicted transcriptional regulators [Transcription]; Region: COG1733 264198002438 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264198002439 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198002440 Predicted transcriptional regulators [Transcription]; Region: COG1733 264198002441 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264198002442 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264198002443 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198002444 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198002445 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198002446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002447 putative substrate translocation pore; other site 264198002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002449 RibD C-terminal domain; Region: RibD_C; cl17279 264198002450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198002451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198002452 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198002453 dimerization interface [polypeptide binding]; other site 264198002454 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198002455 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264198002456 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 264198002457 heme binding site [chemical binding]; other site 264198002458 ferroxidase pore; other site 264198002459 ferroxidase diiron center [ion binding]; other site 264198002460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198002461 Coenzyme A binding pocket [chemical binding]; other site 264198002462 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198002463 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198002464 NADP binding site [chemical binding]; other site 264198002465 dimer interface [polypeptide binding]; other site 264198002466 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 264198002467 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264198002468 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198002469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198002470 DNA-binding site [nucleotide binding]; DNA binding site 264198002471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198002472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002473 homodimer interface [polypeptide binding]; other site 264198002474 catalytic residue [active] 264198002475 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 264198002476 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198002477 inhibitor-cofactor binding pocket; inhibition site 264198002478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002479 catalytic residue [active] 264198002480 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198002481 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 264198002482 tetrameric interface [polypeptide binding]; other site 264198002483 NAD binding site [chemical binding]; other site 264198002484 catalytic residues [active] 264198002485 amino acid transporter; Region: 2A0306; TIGR00909 264198002486 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 264198002487 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198002488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198002489 DNA-binding site [nucleotide binding]; DNA binding site 264198002490 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198002491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002492 homodimer interface [polypeptide binding]; other site 264198002493 catalytic residue [active] 264198002494 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198002495 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 264198002496 B12 binding site [chemical binding]; other site 264198002497 cobalt ligand [ion binding]; other site 264198002498 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 264198002499 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 264198002500 Walker A; other site 264198002501 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 264198002502 putative active site [active] 264198002503 putative substrate binding site [chemical binding]; other site 264198002504 putative coenzyme B12 binding site [chemical binding]; other site 264198002505 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 264198002506 HIT family signature motif; other site 264198002507 catalytic residue [active] 264198002508 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264198002509 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198002510 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198002511 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 264198002512 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 264198002513 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198002514 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198002515 ligand binding site [chemical binding]; other site 264198002516 flexible hinge region; other site 264198002517 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198002518 putative switch regulator; other site 264198002519 non-specific DNA interactions [nucleotide binding]; other site 264198002520 DNA binding site [nucleotide binding] 264198002521 sequence specific DNA binding site [nucleotide binding]; other site 264198002522 putative cAMP binding site [chemical binding]; other site 264198002523 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 264198002524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198002525 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 264198002526 acyl-activating enzyme (AAE) consensus motif; other site 264198002527 putative AMP binding site [chemical binding]; other site 264198002528 putative active site [active] 264198002529 putative CoA binding site [chemical binding]; other site 264198002530 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198002531 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198002532 Walker A/P-loop; other site 264198002533 ATP binding site [chemical binding]; other site 264198002534 Q-loop/lid; other site 264198002535 ABC transporter signature motif; other site 264198002536 Walker B; other site 264198002537 D-loop; other site 264198002538 H-loop/switch region; other site 264198002539 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198002540 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198002541 TM-ABC transporter signature motif; other site 264198002542 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198002543 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198002544 TM-ABC transporter signature motif; other site 264198002545 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 264198002546 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198002547 putative ligand binding site [chemical binding]; other site 264198002548 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198002549 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198002550 Walker A/P-loop; other site 264198002551 ATP binding site [chemical binding]; other site 264198002552 Q-loop/lid; other site 264198002553 ABC transporter signature motif; other site 264198002554 Walker B; other site 264198002555 D-loop; other site 264198002556 H-loop/switch region; other site 264198002557 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264198002558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198002559 acyl-activating enzyme (AAE) consensus motif; other site 264198002560 AMP binding site [chemical binding]; other site 264198002561 active site 264198002562 CoA binding site [chemical binding]; other site 264198002563 Protein of unknown function (DUF454); Region: DUF454; cl01063 264198002564 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198002565 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198002566 FMN binding site [chemical binding]; other site 264198002567 substrate binding site [chemical binding]; other site 264198002568 putative catalytic residue [active] 264198002569 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 264198002570 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198002571 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198002572 FAD binding domain; Region: FAD_binding_3; pfam01494 264198002573 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198002574 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 264198002575 putative active site [active] 264198002576 Fe(II) binding site [ion binding]; other site 264198002577 putative dimer interface [polypeptide binding]; other site 264198002578 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264198002579 putative tetramer interface [polypeptide binding]; other site 264198002580 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198002581 benzoate transport; Region: 2A0115; TIGR00895 264198002582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002583 putative substrate translocation pore; other site 264198002584 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 264198002585 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 264198002586 S-formylglutathione hydrolase; Region: PLN02442 264198002587 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198002588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002589 active site 264198002590 phosphorylation site [posttranslational modification] 264198002591 intermolecular recognition site; other site 264198002592 dimerization interface [polypeptide binding]; other site 264198002593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002594 Walker A motif; other site 264198002595 ATP binding site [chemical binding]; other site 264198002596 Walker B motif; other site 264198002597 arginine finger; other site 264198002598 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198002599 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264198002600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198002601 dimer interface [polypeptide binding]; other site 264198002602 phosphorylation site [posttranslational modification] 264198002603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002604 ATP binding site [chemical binding]; other site 264198002605 Mg2+ binding site [ion binding]; other site 264198002606 G-X-G motif; other site 264198002607 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 264198002608 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198002609 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 264198002610 dimer interface [polypeptide binding]; other site 264198002611 [2Fe-2S] cluster binding site [ion binding]; other site 264198002612 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 264198002613 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198002614 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264198002615 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 264198002616 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 264198002617 hypothetical protein; Provisional; Region: PRK02047 264198002618 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 264198002619 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264198002620 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264198002621 putative RNA binding site [nucleotide binding]; other site 264198002622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002623 S-adenosylmethionine binding site [chemical binding]; other site 264198002624 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264198002625 Part of AAA domain; Region: AAA_19; pfam13245 264198002626 Family description; Region: UvrD_C_2; pfam13538 264198002627 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264198002628 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198002629 catalytic residues [active] 264198002630 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 264198002631 catalytic residues [active] 264198002632 LysE type translocator; Region: LysE; cl00565 264198002633 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264198002634 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264198002635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002636 Walker A motif; other site 264198002637 ATP binding site [chemical binding]; other site 264198002638 Walker B motif; other site 264198002639 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 264198002640 Membrane fusogenic activity; Region: BMFP; pfam04380 264198002641 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 264198002642 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 264198002643 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264198002644 ammonium transporter; Provisional; Region: PRK10666 264198002645 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 264198002646 Glutamate-cysteine ligase; Region: GshA; pfam08886 264198002647 glutathione synthetase; Provisional; Region: PRK05246 264198002648 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 264198002649 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 264198002650 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 264198002651 active pocket/dimerization site; other site 264198002652 active site 264198002653 phosphorylation site [posttranslational modification] 264198002654 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264198002655 dimerization domain swap beta strand [polypeptide binding]; other site 264198002656 regulatory protein interface [polypeptide binding]; other site 264198002657 active site 264198002658 regulatory phosphorylation site [posttranslational modification]; other site 264198002659 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 264198002660 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 264198002661 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264198002662 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264198002663 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 264198002664 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264198002665 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 264198002666 heme binding site [chemical binding]; other site 264198002667 ferroxidase pore; other site 264198002668 ferroxidase diiron center [ion binding]; other site 264198002669 selenophosphate synthetase; Provisional; Region: PRK00943 264198002670 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 264198002671 dimerization interface [polypeptide binding]; other site 264198002672 putative ATP binding site [chemical binding]; other site 264198002673 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 264198002674 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 264198002675 active site residue [active] 264198002676 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 264198002677 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 264198002678 ATP binding site [chemical binding]; other site 264198002679 substrate interface [chemical binding]; other site 264198002680 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264198002681 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264198002682 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264198002683 protein binding site [polypeptide binding]; other site 264198002684 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264198002685 Catalytic dyad [active] 264198002686 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198002687 catalytic core [active] 264198002688 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198002689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264198002690 active site residue [active] 264198002691 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 264198002692 GSH binding site [chemical binding]; other site 264198002693 catalytic residues [active] 264198002694 preprotein translocase subunit SecB; Validated; Region: PRK05751 264198002695 SecA binding site; other site 264198002696 Preprotein binding site; other site 264198002697 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 264198002698 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264198002699 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264198002700 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198002701 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 264198002702 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264198002703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002704 active site 264198002705 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 264198002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002707 S-adenosylmethionine binding site [chemical binding]; other site 264198002708 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 264198002709 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 264198002710 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 264198002711 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198002712 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198002713 Cytochrome c; Region: Cytochrom_C; pfam00034 264198002714 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198002715 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 264198002716 Subunit I/III interface [polypeptide binding]; other site 264198002717 D-pathway; other site 264198002718 Subunit I/VIIc interface [polypeptide binding]; other site 264198002719 Subunit I/IV interface [polypeptide binding]; other site 264198002720 Subunit I/II interface [polypeptide binding]; other site 264198002721 Low-spin heme (heme a) binding site [chemical binding]; other site 264198002722 Subunit I/VIIa interface [polypeptide binding]; other site 264198002723 Subunit I/VIa interface [polypeptide binding]; other site 264198002724 Dimer interface; other site 264198002725 Putative water exit pathway; other site 264198002726 Binuclear center (heme a3/CuB) [ion binding]; other site 264198002727 K-pathway; other site 264198002728 Subunit I/Vb interface [polypeptide binding]; other site 264198002729 Putative proton exit pathway; other site 264198002730 Subunit I/VIb interface; other site 264198002731 Subunit I/VIc interface [polypeptide binding]; other site 264198002732 Electron transfer pathway; other site 264198002733 Subunit I/VIIIb interface [polypeptide binding]; other site 264198002734 Subunit I/VIIb interface [polypeptide binding]; other site 264198002735 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 264198002736 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 264198002737 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 264198002738 Subunit III/VIIa interface [polypeptide binding]; other site 264198002739 Phospholipid binding site [chemical binding]; other site 264198002740 Subunit I/III interface [polypeptide binding]; other site 264198002741 Subunit III/VIb interface [polypeptide binding]; other site 264198002742 Subunit III/VIa interface; other site 264198002743 Subunit III/Vb interface [polypeptide binding]; other site 264198002744 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 264198002745 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 264198002746 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 264198002747 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 264198002748 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 264198002749 UbiA prenyltransferase family; Region: UbiA; pfam01040 264198002750 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 264198002751 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264198002752 Cu(I) binding site [ion binding]; other site 264198002753 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 264198002754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198002755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198002756 DNA binding residues [nucleotide binding] 264198002757 Pirin-related protein [General function prediction only]; Region: COG1741 264198002758 Pirin; Region: Pirin; pfam02678 264198002759 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264198002760 glycosyl transferase family protein; Provisional; Region: PRK08136 264198002761 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264198002762 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198002763 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198002764 Walker A/P-loop; other site 264198002765 ATP binding site [chemical binding]; other site 264198002766 Q-loop/lid; other site 264198002767 ABC transporter signature motif; other site 264198002768 Walker B; other site 264198002769 D-loop; other site 264198002770 H-loop/switch region; other site 264198002771 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198002772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198002773 dimer interface [polypeptide binding]; other site 264198002774 conserved gate region; other site 264198002775 putative PBP binding loops; other site 264198002776 ABC-ATPase subunit interface; other site 264198002777 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264198002778 NMT1-like family; Region: NMT1_2; pfam13379 264198002779 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 264198002780 ANTAR domain; Region: ANTAR; pfam03861 264198002781 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198002782 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198002783 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264198002784 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264198002785 C-terminal domain interface [polypeptide binding]; other site 264198002786 GSH binding site (G-site) [chemical binding]; other site 264198002787 putative dimer interface [polypeptide binding]; other site 264198002788 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264198002789 dimer interface [polypeptide binding]; other site 264198002790 N-terminal domain interface [polypeptide binding]; other site 264198002791 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264198002792 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264198002793 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264198002794 P loop; other site 264198002795 GTP binding site [chemical binding]; other site 264198002796 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198002797 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264198002798 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198002799 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198002800 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198002801 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 264198002802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002803 S-adenosylmethionine binding site [chemical binding]; other site 264198002804 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 264198002805 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 264198002806 active site 264198002807 (T/H)XGH motif; other site 264198002808 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264198002809 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264198002810 putative active site [active] 264198002811 catalytic residue [active] 264198002812 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264198002813 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 264198002814 5S rRNA interface [nucleotide binding]; other site 264198002815 CTC domain interface [polypeptide binding]; other site 264198002816 L16 interface [polypeptide binding]; other site 264198002817 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264198002818 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264198002819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002820 active site 264198002821 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 264198002822 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264198002823 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264198002824 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 264198002825 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 264198002826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198002827 binding surface 264198002828 TPR motif; other site 264198002829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198002830 TPR motif; other site 264198002831 binding surface 264198002832 TPR repeat; Region: TPR_11; pfam13414 264198002833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198002834 binding surface 264198002835 TPR motif; other site 264198002836 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264198002837 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264198002838 DNA binding site [nucleotide binding] 264198002839 catalytic residue [active] 264198002840 H2TH interface [polypeptide binding]; other site 264198002841 putative catalytic residues [active] 264198002842 turnover-facilitating residue; other site 264198002843 intercalation triad [nucleotide binding]; other site 264198002844 8OG recognition residue [nucleotide binding]; other site 264198002845 putative reading head residues; other site 264198002846 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264198002847 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264198002848 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 264198002849 Dynamin family; Region: Dynamin_N; pfam00350 264198002850 G1 box; other site 264198002851 GTP/Mg2+ binding site [chemical binding]; other site 264198002852 G2 box; other site 264198002853 Switch I region; other site 264198002854 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 264198002855 G3 box; other site 264198002856 Switch II region; other site 264198002857 GTP/Mg2+ binding site [chemical binding]; other site 264198002858 G4 box; other site 264198002859 G5 box; other site 264198002860 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 264198002861 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198002862 minor groove reading motif; other site 264198002863 helix-hairpin-helix signature motif; other site 264198002864 substrate binding pocket [chemical binding]; other site 264198002865 active site 264198002866 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 264198002867 DNA binding and oxoG recognition site [nucleotide binding] 264198002868 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 264198002869 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 264198002870 AAA domain; Region: AAA_18; pfam13238 264198002871 hypothetical protein; Provisional; Region: PRK11505 264198002872 psiF repeat; Region: PsiF_repeat; pfam07769 264198002873 HPr kinase/phosphorylase; Provisional; Region: PRK05428 264198002874 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 264198002875 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 264198002876 Hpr binding site; other site 264198002877 active site 264198002878 homohexamer subunit interaction site [polypeptide binding]; other site 264198002879 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264198002880 active site 264198002881 phosphorylation site [posttranslational modification] 264198002882 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 264198002883 30S subunit binding site; other site 264198002884 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264198002885 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 264198002886 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264198002887 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264198002888 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 264198002889 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 264198002890 Walker A/P-loop; other site 264198002891 ATP binding site [chemical binding]; other site 264198002892 Q-loop/lid; other site 264198002893 ABC transporter signature motif; other site 264198002894 Walker B; other site 264198002895 D-loop; other site 264198002896 H-loop/switch region; other site 264198002897 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 264198002898 OstA-like protein; Region: OstA; pfam03968 264198002899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 264198002900 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 264198002901 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 264198002902 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264198002903 putative active site [active] 264198002904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264198002905 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264198002906 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 264198002907 TrkA-N domain; Region: TrkA_N; pfam02254 264198002908 TrkA-C domain; Region: TrkA_C; pfam02080 264198002909 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 264198002910 intracellular protease, PfpI family; Region: PfpI; TIGR01382 264198002911 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 264198002912 conserved cys residue [active] 264198002913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002914 active site 264198002915 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264198002916 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264198002917 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264198002918 PhoU domain; Region: PhoU; pfam01895 264198002919 PhoU domain; Region: PhoU; pfam01895 264198002920 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 264198002921 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264198002922 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198002923 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198002924 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264198002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198002927 putative substrate translocation pore; other site 264198002928 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264198002929 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264198002930 dimer interface [polypeptide binding]; other site 264198002931 ssDNA binding site [nucleotide binding]; other site 264198002932 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264198002933 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198002934 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198002935 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198002936 Autotransporter beta-domain; Region: Autotransporter; smart00869 264198002937 Protein of unknown function, DUF485; Region: DUF485; pfam04341 264198002938 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198002939 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198002940 Na binding site [ion binding]; other site 264198002941 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 264198002942 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 264198002943 Haemagglutinin; Region: HIM; pfam05662 264198002944 YadA-like C-terminal region; Region: YadA; pfam03895 264198002945 Cupin domain; Region: Cupin_2; pfam07883 264198002946 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 264198002947 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198002948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198002949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198002950 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 264198002951 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198002952 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198002953 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198002954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 264198002955 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 264198002956 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198002957 tetramer interface [polypeptide binding]; other site 264198002958 active site 264198002959 Mg2+/Mn2+ binding site [ion binding]; other site 264198002960 isocitrate lyase; Region: PLN02892 264198002961 mercuric reductase; Validated; Region: PRK06370 264198002962 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198002963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198002964 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198002965 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198002966 nucleophile elbow; other site 264198002967 Patatin phospholipase; Region: DUF3734; pfam12536 264198002968 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 264198002969 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 264198002970 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198002971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002972 active site 264198002973 phosphorylation site [posttranslational modification] 264198002974 intermolecular recognition site; other site 264198002975 dimerization interface [polypeptide binding]; other site 264198002976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198002977 DNA binding site [nucleotide binding] 264198002978 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 264198002979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198002980 dimerization interface [polypeptide binding]; other site 264198002981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198002982 dimer interface [polypeptide binding]; other site 264198002983 phosphorylation site [posttranslational modification] 264198002984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002985 ATP binding site [chemical binding]; other site 264198002986 Mg2+ binding site [ion binding]; other site 264198002987 G-X-G motif; other site 264198002988 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 264198002989 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 264198002990 Ion channel; Region: Ion_trans_2; pfam07885 264198002991 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198002992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198002993 substrate binding pocket [chemical binding]; other site 264198002994 membrane-bound complex binding site; other site 264198002995 hinge residues; other site 264198002996 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198002997 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198002998 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198002999 putative active site [active] 264198003000 hypothetical protein; Provisional; Region: PRK07483 264198003001 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198003002 inhibitor-cofactor binding pocket; inhibition site 264198003003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198003004 catalytic residue [active] 264198003005 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264198003006 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 264198003007 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 264198003008 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 264198003009 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264198003010 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 264198003011 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 264198003012 aspartate aminotransferase; Provisional; Region: PRK06108 264198003013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198003014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198003015 homodimer interface [polypeptide binding]; other site 264198003016 catalytic residue [active] 264198003017 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198003018 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 264198003019 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264198003020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264198003021 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264198003022 Walker A/P-loop; other site 264198003023 ATP binding site [chemical binding]; other site 264198003024 Q-loop/lid; other site 264198003025 ABC transporter signature motif; other site 264198003026 Walker B; other site 264198003027 D-loop; other site 264198003028 H-loop/switch region; other site 264198003029 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198003030 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198003031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198003032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198003033 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 264198003034 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 264198003035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 264198003036 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 264198003037 threonine dehydratase; Reviewed; Region: PRK09224 264198003038 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264198003039 tetramer interface [polypeptide binding]; other site 264198003040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198003041 catalytic residue [active] 264198003042 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264198003043 putative Ile/Val binding site [chemical binding]; other site 264198003044 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264198003045 putative Ile/Val binding site [chemical binding]; other site 264198003046 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 264198003047 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 264198003048 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 264198003049 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 264198003050 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 264198003051 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 264198003052 active site 264198003053 homotetramer interface [polypeptide binding]; other site 264198003054 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 264198003055 aromatic arch; other site 264198003056 DCoH dimer interaction site [polypeptide binding]; other site 264198003057 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 264198003058 DCoH tetramer interaction site [polypeptide binding]; other site 264198003059 substrate binding site [chemical binding]; other site 264198003060 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 264198003061 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 264198003062 Ligand binding site; other site 264198003063 metal-binding site 264198003064 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 264198003065 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264198003066 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264198003067 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 264198003068 putative hydrophobic ligand binding site [chemical binding]; other site 264198003069 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 264198003070 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264198003071 metal ion-dependent adhesion site (MIDAS); other site 264198003072 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198003073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198003074 Walker A motif; other site 264198003075 ATP binding site [chemical binding]; other site 264198003076 Walker B motif; other site 264198003077 arginine finger; other site 264198003078 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198003079 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 264198003080 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198003081 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198003082 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198003083 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198003084 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198003085 Predicted membrane protein [Function unknown]; Region: COG1238 264198003086 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 264198003087 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198003088 FAD binding domain; Region: FAD_binding_4; pfam01565 264198003089 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198003090 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 264198003091 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198003092 Cysteine-rich domain; Region: CCG; pfam02754 264198003093 Cysteine-rich domain; Region: CCG; pfam02754 264198003094 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 264198003095 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 264198003096 HIT family signature motif; other site 264198003097 catalytic residue [active] 264198003098 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 264198003099 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 264198003100 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 264198003101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 264198003102 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264198003103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003104 S-adenosylmethionine binding site [chemical binding]; other site 264198003105 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 264198003106 SCP-2 sterol transfer family; Region: SCP2; pfam02036 264198003107 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 264198003108 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 264198003109 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 264198003110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003111 S-adenosylmethionine binding site [chemical binding]; other site 264198003112 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 264198003113 Na binding site [ion binding]; other site 264198003114 putative glycosylation site [posttranslational modification]; other site 264198003115 putative glycosylation site [posttranslational modification]; other site 264198003116 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 264198003117 Uncharacterized conserved protein [Function unknown]; Region: COG2928 264198003118 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264198003119 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264198003120 dimer interface [polypeptide binding]; other site 264198003121 anticodon binding site; other site 264198003122 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264198003123 homodimer interface [polypeptide binding]; other site 264198003124 motif 1; other site 264198003125 active site 264198003126 motif 2; other site 264198003127 GAD domain; Region: GAD; pfam02938 264198003128 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264198003129 motif 3; other site 264198003130 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 264198003131 nudix motif; other site 264198003132 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 264198003133 putative catalytic site [active] 264198003134 putative metal binding site [ion binding]; other site 264198003135 putative phosphate binding site [ion binding]; other site 264198003136 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 264198003137 Walker A motif; other site 264198003138 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264198003139 PLD-like domain; Region: PLDc_2; pfam13091 264198003140 putative active site [active] 264198003141 catalytic site [active] 264198003142 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198003143 PLD-like domain; Region: PLDc_2; pfam13091 264198003144 putative active site [active] 264198003145 catalytic site [active] 264198003146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198003147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198003148 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198003149 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198003150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198003151 active site 264198003152 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198003153 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 264198003154 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198003155 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198003156 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198003157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198003158 substrate binding site [chemical binding]; other site 264198003159 oxyanion hole (OAH) forming residues; other site 264198003160 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 264198003161 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198003162 dimer interface [polypeptide binding]; other site 264198003163 active site 264198003164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 264198003165 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 264198003166 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198003167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198003168 substrate binding site [chemical binding]; other site 264198003169 oxyanion hole (OAH) forming residues; other site 264198003170 trimer interface [polypeptide binding]; other site 264198003171 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264198003172 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264198003173 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 264198003174 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 264198003175 Walker A/P-loop; other site 264198003176 ATP binding site [chemical binding]; other site 264198003177 Q-loop/lid; other site 264198003178 ABC transporter signature motif; other site 264198003179 Walker B; other site 264198003180 D-loop; other site 264198003181 H-loop/switch region; other site 264198003182 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198003183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198003184 putative DNA binding site [nucleotide binding]; other site 264198003185 putative Zn2+ binding site [ion binding]; other site 264198003186 AsnC family; Region: AsnC_trans_reg; pfam01037 264198003187 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 264198003188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198003189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198003190 dimerization interface [polypeptide binding]; other site 264198003191 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 264198003192 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198003193 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 264198003194 NAD(P) binding site [chemical binding]; other site 264198003195 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198003196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198003197 substrate binding pocket [chemical binding]; other site 264198003198 membrane-bound complex binding site; other site 264198003199 hinge residues; other site 264198003200 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198003201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198003202 dimer interface [polypeptide binding]; other site 264198003203 conserved gate region; other site 264198003204 putative PBP binding loops; other site 264198003205 ABC-ATPase subunit interface; other site 264198003206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198003207 dimer interface [polypeptide binding]; other site 264198003208 conserved gate region; other site 264198003209 putative PBP binding loops; other site 264198003210 ABC-ATPase subunit interface; other site 264198003211 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198003212 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264198003213 Walker A/P-loop; other site 264198003214 ATP binding site [chemical binding]; other site 264198003215 Q-loop/lid; other site 264198003216 ABC transporter signature motif; other site 264198003217 Walker B; other site 264198003218 D-loop; other site 264198003219 H-loop/switch region; other site 264198003220 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 264198003221 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 264198003222 putative active site [active] 264198003223 putative dimer interface [polypeptide binding]; other site 264198003224 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264198003225 tartrate dehydrogenase; Region: TTC; TIGR02089 264198003226 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 264198003227 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 264198003228 MOFRL family; Region: MOFRL; pfam05161 264198003229 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 264198003230 active site 264198003231 substrate binding pocket [chemical binding]; other site 264198003232 dimer interface [polypeptide binding]; other site 264198003233 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 264198003234 OsmC-like protein; Region: OsmC; cl00767 264198003235 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264198003236 23S rRNA interface [nucleotide binding]; other site 264198003237 L3 interface [polypeptide binding]; other site 264198003238 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 264198003239 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 264198003240 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 264198003241 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 264198003242 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 264198003243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198003244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198003245 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198003246 dimerization interface [polypeptide binding]; other site 264198003247 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 264198003248 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 264198003249 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198003250 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264198003251 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264198003252 active site 264198003253 HIGH motif; other site 264198003254 dimer interface [polypeptide binding]; other site 264198003255 KMSKS motif; other site 264198003256 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198003257 RNA binding surface [nucleotide binding]; other site 264198003258 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264198003259 putative active site [active] 264198003260 dimerization interface [polypeptide binding]; other site 264198003261 putative tRNAtyr binding site [nucleotide binding]; other site 264198003262 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 264198003263 substrate binding site [chemical binding]; other site 264198003264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198003265 catalytic core [active] 264198003266 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 264198003267 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 264198003268 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264198003269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198003270 Walker A motif; other site 264198003271 ATP binding site [chemical binding]; other site 264198003272 Walker B motif; other site 264198003273 arginine finger; other site 264198003274 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264198003275 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264198003276 RuvA N terminal domain; Region: RuvA_N; pfam01330 264198003277 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264198003278 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264198003279 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 264198003280 putative active site [active] 264198003281 catalytic site [active] 264198003282 putative metal binding site [ion binding]; other site 264198003283 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 264198003284 active site 264198003285 putative DNA-binding cleft [nucleotide binding]; other site 264198003286 dimer interface [polypeptide binding]; other site 264198003287 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 264198003288 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264198003289 purine monophosphate binding site [chemical binding]; other site 264198003290 dimer interface [polypeptide binding]; other site 264198003291 putative catalytic residues [active] 264198003292 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 264198003293 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264198003294 DNA-binding protein Fis; Provisional; Region: PRK01905 264198003295 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264198003296 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264198003297 FMN binding site [chemical binding]; other site 264198003298 active site 264198003299 catalytic residues [active] 264198003300 substrate binding site [chemical binding]; other site 264198003301 hypothetical protein; Provisional; Region: PRK06996 264198003302 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198003303 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 264198003304 proline aminopeptidase P II; Provisional; Region: PRK10879 264198003305 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 264198003306 active site 264198003307 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264198003308 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 264198003309 Substrate binding site; other site 264198003310 metal-binding site 264198003311 Predicted membrane protein [Function unknown]; Region: COG4392 264198003312 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 264198003313 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 264198003314 Phosphotransferase enzyme family; Region: APH; pfam01636 264198003315 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 264198003316 OstA-like protein; Region: OstA; cl00844 264198003317 Organic solvent tolerance protein; Region: OstA_C; pfam04453 264198003318 SurA N-terminal domain; Region: SurA_N; pfam09312 264198003319 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 264198003320 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264198003321 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 264198003322 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 264198003323 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 264198003324 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 264198003325 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264198003326 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264198003327 active site 264198003328 HIGH motif; other site 264198003329 dimer interface [polypeptide binding]; other site 264198003330 KMSKS motif; other site 264198003331 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198003332 EamA-like transporter family; Region: EamA; pfam00892 264198003333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198003334 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 264198003335 dimer interface [polypeptide binding]; other site 264198003336 active site 264198003337 metal binding site [ion binding]; metal-binding site 264198003338 glutathione binding site [chemical binding]; other site 264198003339 Protein of unknown function DUF45; Region: DUF45; pfam01863 264198003340 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264198003341 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198003342 putative acyl-acceptor binding pocket; other site 264198003343 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 264198003344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198003345 active site 264198003346 motif I; other site 264198003347 motif II; other site 264198003348 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 264198003349 DALR anticodon binding domain; Region: DALR_1; smart00836 264198003350 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 264198003351 dimer interface [polypeptide binding]; other site 264198003352 motif 1; other site 264198003353 active site 264198003354 motif 2; other site 264198003355 motif 3; other site 264198003356 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 264198003357 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 264198003358 putative active site [active] 264198003359 catalytic triad [active] 264198003360 putative dimer interface [polypeptide binding]; other site 264198003361 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 264198003362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264198003363 Transporter associated domain; Region: CorC_HlyC; smart01091 264198003364 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 264198003365 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 264198003366 PhoH-like protein; Region: PhoH; pfam02562 264198003367 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 264198003368 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264198003369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198003370 FeS/SAM binding site; other site 264198003371 TRAM domain; Region: TRAM; pfam01938 264198003372 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 264198003373 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 264198003374 Cl- selectivity filter; other site 264198003375 Cl- binding residues [ion binding]; other site 264198003376 pore gating glutamate residue; other site 264198003377 dimer interface [polypeptide binding]; other site 264198003378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 264198003379 helicase 45; Provisional; Region: PTZ00424 264198003380 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198003381 ATP binding site [chemical binding]; other site 264198003382 Mg++ binding site [ion binding]; other site 264198003383 motif III; other site 264198003384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198003385 nucleotide binding region [chemical binding]; other site 264198003386 ATP-binding site [chemical binding]; other site 264198003387 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 264198003388 serine/threonine protein kinase; Provisional; Region: PRK11768 264198003389 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198003390 Ligand Binding Site [chemical binding]; other site 264198003391 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198003392 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198003393 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198003394 transcriptional regulator NarP; Provisional; Region: PRK10403 264198003395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198003396 active site 264198003397 phosphorylation site [posttranslational modification] 264198003398 intermolecular recognition site; other site 264198003399 dimerization interface [polypeptide binding]; other site 264198003400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198003401 DNA binding residues [nucleotide binding] 264198003402 dimerization interface [polypeptide binding]; other site 264198003403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198003404 putative substrate translocation pore; other site 264198003405 putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647 264198003406 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198003407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198003408 HAMP domain; Region: HAMP; pfam00672 264198003409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198003410 dimer interface [polypeptide binding]; other site 264198003411 phosphorylation site [posttranslational modification] 264198003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198003413 ATP binding site [chemical binding]; other site 264198003414 Mg2+ binding site [ion binding]; other site 264198003415 G-X-G motif; other site 264198003416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198003417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198003418 active site 264198003419 phosphorylation site [posttranslational modification] 264198003420 intermolecular recognition site; other site 264198003421 dimerization interface [polypeptide binding]; other site 264198003422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198003423 DNA binding site [nucleotide binding] 264198003424 recombinase A; Provisional; Region: recA; PRK09354 264198003425 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264198003426 hexamer interface [polypeptide binding]; other site 264198003427 Walker A motif; other site 264198003428 ATP binding site [chemical binding]; other site 264198003429 Walker B motif; other site 264198003430 RecX family; Region: RecX; cl00936 264198003431 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264198003432 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 264198003433 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 264198003434 CoA-ligase; Region: Ligase_CoA; pfam00549 264198003435 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 264198003436 CoA binding domain; Region: CoA_binding; smart00881 264198003437 CoA-ligase; Region: Ligase_CoA; pfam00549 264198003438 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 264198003439 putative major pilin subunit; Provisional; Region: PRK10574 264198003440 O-Antigen ligase; Region: Wzy_C; pfam04932 264198003441 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 264198003442 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 264198003443 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 264198003444 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198003445 DNA-binding site [nucleotide binding]; DNA binding site 264198003446 RNA-binding motif; other site 264198003447 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 264198003448 Restriction endonuclease; Region: Mrr_cat; pfam04471 264198003449 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264198003450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198003451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198003452 metal binding site [ion binding]; metal-binding site 264198003453 active site 264198003454 I-site; other site 264198003455 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 264198003456 trimer interface [polypeptide binding]; other site 264198003457 dimer interface [polypeptide binding]; other site 264198003458 putative active site [active] 264198003459 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 264198003460 Peptidase family M48; Region: Peptidase_M48; pfam01435 264198003461 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 264198003462 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 264198003463 T-complex protein 11; Region: Tcp11; pfam05794 264198003464 SnoaL-like domain; Region: SnoaL_3; pfam13474 264198003465 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198003466 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198003467 putative active site [active] 264198003468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 264198003469 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264198003470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198003471 ATP binding site [chemical binding]; other site 264198003472 putative Mg++ binding site [ion binding]; other site 264198003473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198003474 nucleotide binding region [chemical binding]; other site 264198003475 ATP-binding site [chemical binding]; other site 264198003476 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198003477 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 264198003478 PAAR motif; Region: PAAR_motif; pfam05488 264198003479 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 264198003480 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 264198003481 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 264198003482 ATP-grasp domain; Region: ATP-grasp; pfam02222 264198003483 AIR carboxylase; Region: AIRC; pfam00731 264198003484 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 264198003485 ATP binding site [chemical binding]; other site 264198003486 active site 264198003487 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 264198003488 substrate binding site [chemical binding]; other site 264198003489 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 264198003490 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264198003491 intersubunit interface [polypeptide binding]; other site 264198003492 active site 264198003493 zinc binding site [ion binding]; other site 264198003494 Na+ binding site [ion binding]; other site 264198003495 pyruvate kinase; Provisional; Region: PRK05826 264198003496 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 264198003497 domain interfaces; other site 264198003498 active site 264198003499 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 264198003500 Phosphoglycerate kinase; Region: PGK; pfam00162 264198003501 substrate binding site [chemical binding]; other site 264198003502 hinge regions; other site 264198003503 ADP binding site [chemical binding]; other site 264198003504 catalytic site [active] 264198003505 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 264198003506 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 264198003507 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 264198003508 AzlC protein; Region: AzlC; pfam03591 264198003509 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 264198003510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198003511 MarR family; Region: MarR_2; pfam12802 264198003512 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 264198003513 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 264198003514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198003515 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198003516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198003517 dimerization interface [polypeptide binding]; other site 264198003518 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198003519 MULE transposase domain; Region: MULE; pfam10551 264198003520 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198003521 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 264198003522 Protein export membrane protein; Region: SecD_SecF; cl14618 264198003523 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 264198003524 Protein export membrane protein; Region: SecD_SecF; cl14618 264198003525 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198003526 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198003527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198003528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198003529 active site 264198003530 phosphorylation site [posttranslational modification] 264198003531 intermolecular recognition site; other site 264198003532 dimerization interface [polypeptide binding]; other site 264198003533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198003534 DNA binding site [nucleotide binding] 264198003535 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 264198003536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198003537 dimerization interface [polypeptide binding]; other site 264198003538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198003539 dimer interface [polypeptide binding]; other site 264198003540 phosphorylation site [posttranslational modification] 264198003541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198003542 ATP binding site [chemical binding]; other site 264198003543 Mg2+ binding site [ion binding]; other site 264198003544 G-X-G motif; other site 264198003545 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 264198003546 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 264198003547 putative deacylase active site [active] 264198003548 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 264198003549 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264198003550 active site 264198003551 Int/Topo IB signature motif; other site 264198003552 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 264198003553 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264198003554 DNA binding site [nucleotide binding] 264198003555 active site 264198003556 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198003557 Predicted permeases [General function prediction only]; Region: COG0679 264198003558 epoxyqueuosine reductase; Region: TIGR00276 264198003559 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 264198003560 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 264198003561 AMIN domain; Region: AMIN; pfam11741 264198003562 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264198003563 active site 264198003564 metal binding site [ion binding]; metal-binding site 264198003565 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 264198003566 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 264198003567 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198003568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198003569 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198003570 putative dimerization interface [polypeptide binding]; other site 264198003571 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198003572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003573 S-adenosylmethionine binding site [chemical binding]; other site 264198003574 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 264198003575 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 264198003576 NAD binding site [chemical binding]; other site 264198003577 homodimer interface [polypeptide binding]; other site 264198003578 homotetramer interface [polypeptide binding]; other site 264198003579 active site 264198003580 adenylate kinase; Reviewed; Region: adk; PRK00279 264198003581 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264198003582 AMP-binding site [chemical binding]; other site 264198003583 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264198003584 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 264198003585 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 264198003586 Ligand binding site; other site 264198003587 oligomer interface; other site 264198003588 Uncharacterized conserved protein [Function unknown]; Region: COG2835 264198003589 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 264198003590 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 264198003591 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264198003592 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264198003593 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264198003594 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264198003595 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264198003596 generic binding surface II; other site 264198003597 generic binding surface I; other site 264198003598 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264198003599 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264198003600 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264198003601 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 264198003602 Hemerythrin-like domain; Region: Hr-like; cd12108 264198003603 Fe binding site [ion binding]; other site 264198003604 Protein of unknown function DUF72; Region: DUF72; pfam01904 264198003605 CheB methylesterase; Region: CheB_methylest; pfam01339 264198003606 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 264198003607 Competence-damaged protein; Region: CinA; pfam02464 264198003608 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198003609 Predicted membrane protein [Function unknown]; Region: COG1289 264198003610 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264198003611 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 264198003612 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264198003613 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 264198003614 Cl binding site [ion binding]; other site 264198003615 oligomer interface [polypeptide binding]; other site 264198003616 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 264198003617 Ferredoxin [Energy production and conversion]; Region: COG1146 264198003618 4Fe-4S binding domain; Region: Fer4; pfam00037 264198003619 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 264198003620 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 264198003621 PBP superfamily domain; Region: PBP_like; pfam12727 264198003622 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 264198003623 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 264198003624 putative dimer interface [polypeptide binding]; other site 264198003625 [2Fe-2S] cluster binding site [ion binding]; other site 264198003626 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 264198003627 putative dimer interface [polypeptide binding]; other site 264198003628 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198003629 SLBB domain; Region: SLBB; pfam10531 264198003630 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 264198003631 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 264198003632 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198003633 catalytic loop [active] 264198003634 iron binding site [ion binding]; other site 264198003635 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264198003636 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 264198003637 [4Fe-4S] binding site [ion binding]; other site 264198003638 molybdopterin cofactor binding site; other site 264198003639 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 264198003640 molybdopterin cofactor binding site; other site 264198003641 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 264198003642 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 264198003643 Transglycosylase; Region: Transgly; pfam00912 264198003644 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590 264198003645 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 264198003646 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 264198003647 propionate/acetate kinase; Provisional; Region: PRK12379 264198003648 Acetokinase family; Region: Acetate_kinase; cl17229 264198003649 phosphate acetyltransferase; Provisional; Region: PRK11890 264198003650 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 264198003651 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 264198003652 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 264198003653 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 264198003654 NAD binding site [chemical binding]; other site 264198003655 homotetramer interface [polypeptide binding]; other site 264198003656 homodimer interface [polypeptide binding]; other site 264198003657 substrate binding site [chemical binding]; other site 264198003658 active site 264198003659 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590 264198003660 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 264198003661 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 264198003662 molybdenum-pterin binding domain; Region: Mop; TIGR00638 264198003663 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 264198003664 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 264198003665 putative active site [active] 264198003666 putative metal binding residues [ion binding]; other site 264198003667 signature motif; other site 264198003668 putative triphosphate binding site [ion binding]; other site 264198003669 dimer interface [polypeptide binding]; other site 264198003670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198003671 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 264198003672 Walker A/P-loop; other site 264198003673 ATP binding site [chemical binding]; other site 264198003674 Q-loop/lid; other site 264198003675 ABC transporter signature motif; other site 264198003676 Walker B; other site 264198003677 D-loop; other site 264198003678 H-loop/switch region; other site 264198003679 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264198003680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198003681 putative PBP binding loops; other site 264198003682 dimer interface [polypeptide binding]; other site 264198003683 ABC-ATPase subunit interface; other site 264198003684 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198003685 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264198003686 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198003687 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 264198003688 putative ligand binding site [chemical binding]; other site 264198003689 NAD binding site [chemical binding]; other site 264198003690 catalytic site [active] 264198003691 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 264198003692 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198003693 MULE transposase domain; Region: MULE; pfam10551 264198003694 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 264198003695 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198003696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198003697 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 264198003698 putative dimerization interface [polypeptide binding]; other site 264198003699 putative substrate binding pocket [chemical binding]; other site 264198003700 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 264198003701 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 264198003702 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 264198003703 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198003704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198003705 DNA-binding site [nucleotide binding]; DNA binding site 264198003706 FCD domain; Region: FCD; pfam07729 264198003707 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 264198003708 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198003709 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198003710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198003711 substrate binding site [chemical binding]; other site 264198003712 oxyanion hole (OAH) forming residues; other site 264198003713 trimer interface [polypeptide binding]; other site 264198003714 malonyl-CoA synthase; Validated; Region: PRK07514 264198003715 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 264198003716 acyl-activating enzyme (AAE) consensus motif; other site 264198003717 active site 264198003718 AMP binding site [chemical binding]; other site 264198003719 CoA binding site [chemical binding]; other site 264198003720 Protein of unknown function (DUF541); Region: SIMPL; cl01077 264198003721 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198003722 Uncharacterized conserved protein [Function unknown]; Region: COG2947 264198003723 Cell division protein ZapA; Region: ZapA; pfam05164 264198003724 Autophagy protein Apg6; Region: APG6; pfam04111 264198003725 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 264198003726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198003727 N-terminal plug; other site 264198003728 ligand-binding site [chemical binding]; other site 264198003729 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 264198003730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264198003731 ABC-ATPase subunit interface; other site 264198003732 dimer interface [polypeptide binding]; other site 264198003733 putative PBP binding regions; other site 264198003734 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264198003735 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264198003736 Walker A/P-loop; other site 264198003737 ATP binding site [chemical binding]; other site 264198003738 Q-loop/lid; other site 264198003739 ABC transporter signature motif; other site 264198003740 Walker B; other site 264198003741 D-loop; other site 264198003742 H-loop/switch region; other site 264198003743 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 264198003744 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 264198003745 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 264198003746 homodimer interface [polypeptide binding]; other site 264198003747 Walker A motif; other site 264198003748 ATP binding site [chemical binding]; other site 264198003749 hydroxycobalamin binding site [chemical binding]; other site 264198003750 Walker B motif; other site 264198003751 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 264198003752 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 264198003753 active site pocket [active] 264198003754 putative dimer interface [polypeptide binding]; other site 264198003755 putative cataytic base [active] 264198003756 cobalamin synthase; Reviewed; Region: cobS; PRK00235 264198003757 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198003758 catalytic core [active] 264198003759 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 264198003760 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 264198003761 cobalamin binding residues [chemical binding]; other site 264198003762 putative BtuC binding residues; other site 264198003763 dimer interface [polypeptide binding]; other site 264198003764 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 264198003765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198003766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198003767 homodimer interface [polypeptide binding]; other site 264198003768 catalytic residue [active] 264198003769 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 264198003770 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 264198003771 homotrimer interface [polypeptide binding]; other site 264198003772 Walker A motif; other site 264198003773 GTP binding site [chemical binding]; other site 264198003774 Walker B motif; other site 264198003775 cobyric acid synthase; Provisional; Region: PRK00784 264198003776 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 264198003777 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264198003778 catalytic triad [active] 264198003779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198003780 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264198003781 Coenzyme A binding pocket [chemical binding]; other site 264198003782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264198003783 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264198003784 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 264198003785 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264198003786 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 264198003787 pantoate--beta-alanine ligase; Region: panC; TIGR00018 264198003788 Pantoate-beta-alanine ligase; Region: PanC; cd00560 264198003789 active site 264198003790 ATP-binding site [chemical binding]; other site 264198003791 pantoate-binding site; other site 264198003792 HXXH motif; other site 264198003793 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 264198003794 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 264198003795 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 264198003796 Surface antigen; Region: Bac_surface_Ag; pfam01103 264198003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 264198003798 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264198003799 Family of unknown function (DUF490); Region: DUF490; pfam04357 264198003800 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 264198003801 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 264198003802 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264198003803 active site 264198003804 HIGH motif; other site 264198003805 KMSKS motif; other site 264198003806 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264198003807 tRNA binding surface [nucleotide binding]; other site 264198003808 anticodon binding site; other site 264198003809 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264198003810 dimer interface [polypeptide binding]; other site 264198003811 putative tRNA-binding site [nucleotide binding]; other site 264198003812 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198003813 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198003814 ligand binding site [chemical binding]; other site 264198003815 antiporter inner membrane protein; Provisional; Region: PRK11670 264198003816 Domain of unknown function DUF59; Region: DUF59; pfam01883 264198003817 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264198003818 Walker A motif; other site 264198003819 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 264198003820 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 264198003821 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 264198003822 4Fe-4S binding domain; Region: Fer4; pfam00037 264198003823 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264198003824 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264198003825 4Fe-4S binding domain; Region: Fer4; pfam00037 264198003826 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198003827 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264198003828 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 264198003829 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 264198003830 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198003831 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 264198003832 [4Fe-4S] binding site [ion binding]; other site 264198003833 molybdopterin cofactor binding site; other site 264198003834 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198003835 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198003836 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 264198003837 molybdopterin cofactor binding site; other site 264198003838 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264198003839 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 264198003840 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 264198003841 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 264198003842 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264198003843 trimer interface [polypeptide binding]; other site 264198003844 active site 264198003845 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 264198003846 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 264198003847 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198003848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198003849 catalytic residue [active] 264198003850 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 264198003851 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198003852 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264198003853 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264198003854 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198003855 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 264198003856 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198003857 putative ADP-binding pocket [chemical binding]; other site 264198003858 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 264198003859 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 264198003860 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 264198003861 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 264198003862 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 264198003863 argininosuccinate lyase; Provisional; Region: PRK00855 264198003864 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264198003865 active sites [active] 264198003866 tetramer interface [polypeptide binding]; other site 264198003867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 264198003868 Anti-sigma-K factor rskA; Region: RskA; pfam10099 264198003869 RNA polymerase sigma factor; Provisional; Region: PRK12514 264198003870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198003871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198003872 DNA binding residues [nucleotide binding] 264198003873 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198003874 dinuclear metal binding motif [ion binding]; other site 264198003875 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 264198003876 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 264198003877 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 264198003878 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 264198003879 domain interfaces; other site 264198003880 active site 264198003881 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 264198003882 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264198003883 active site 264198003884 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 264198003885 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 264198003886 HemY protein N-terminus; Region: HemY_N; pfam07219 264198003887 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 264198003888 DNA photolyase; Region: DNA_photolyase; pfam00875 264198003889 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264198003890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198003891 RNA binding surface [nucleotide binding]; other site 264198003892 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 264198003893 active site 264198003894 uracil binding [chemical binding]; other site 264198003895 hypothetical protein; Validated; Region: PRK00228 264198003896 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 264198003897 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 264198003898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198003899 active site 264198003900 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264198003901 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264198003902 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264198003903 dihydroorotase; Provisional; Region: PRK07627 264198003904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198003905 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 264198003906 active site 264198003907 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264198003908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198003909 putative acyl-acceptor binding pocket; other site 264198003910 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 264198003911 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 264198003912 active site 264198003913 metal binding site [ion binding]; metal-binding site 264198003914 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264198003915 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264198003916 NAD binding site [chemical binding]; other site 264198003917 substrate binding site [chemical binding]; other site 264198003918 homodimer interface [polypeptide binding]; other site 264198003919 active site 264198003920 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 264198003921 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 264198003922 NADP binding site [chemical binding]; other site 264198003923 active site 264198003924 putative substrate binding site [chemical binding]; other site 264198003925 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264198003926 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264198003927 substrate binding site; other site 264198003928 tetramer interface; other site 264198003929 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 264198003930 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 264198003931 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264198003932 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 264198003933 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 264198003934 Walker A/P-loop; other site 264198003935 ATP binding site [chemical binding]; other site 264198003936 Q-loop/lid; other site 264198003937 ABC transporter signature motif; other site 264198003938 Walker B; other site 264198003939 D-loop; other site 264198003940 H-loop/switch region; other site 264198003941 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 264198003942 putative carbohydrate binding site [chemical binding]; other site 264198003943 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264198003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003945 S-adenosylmethionine binding site [chemical binding]; other site 264198003946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 264198003947 IncA protein; Region: IncA; pfam04156 264198003948 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198003949 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264198003950 Probable Catalytic site; other site 264198003951 metal-binding site 264198003952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198003953 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 264198003954 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198003955 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 264198003956 NADP-binding site; other site 264198003957 homotetramer interface [polypeptide binding]; other site 264198003958 substrate binding site [chemical binding]; other site 264198003959 homodimer interface [polypeptide binding]; other site 264198003960 active site 264198003961 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 264198003962 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264198003963 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 264198003964 dimer interface [polypeptide binding]; other site 264198003965 active site 264198003966 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 264198003967 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 264198003968 Substrate binding site; other site 264198003969 Mg++ binding site; other site 264198003970 metal-binding site 264198003971 Mg++ binding site; other site 264198003972 metal-binding site 264198003973 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 264198003974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198003975 active site 264198003976 motif I; other site 264198003977 motif II; other site 264198003978 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264198003979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198003980 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 264198003981 Mg++ binding site [ion binding]; other site 264198003982 putative catalytic motif [active] 264198003983 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264198003984 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264198003985 Ligand binding site; other site 264198003986 Putative Catalytic site; other site 264198003987 DXD motif; other site 264198003988 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264198003989 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 264198003990 active site 264198003991 ATP binding site [chemical binding]; other site 264198003992 substrate binding site [chemical binding]; other site 264198003993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198003994 active site 264198003995 motif I; other site 264198003996 motif II; other site 264198003997 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 264198003998 Ligand binding site; other site 264198003999 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264198004000 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 264198004001 AAA domain; Region: AAA_33; pfam13671 264198004002 ligand-binding site [chemical binding]; other site 264198004003 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 264198004004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198004005 putative ADP-binding pocket [chemical binding]; other site 264198004006 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264198004007 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264198004008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198004009 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 264198004010 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 264198004011 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264198004012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198004013 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 264198004014 putative ADP-binding pocket [chemical binding]; other site 264198004015 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 264198004016 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 264198004017 active site 264198004018 substrate binding site [chemical binding]; other site 264198004019 metal binding site [ion binding]; metal-binding site 264198004020 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198004021 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 264198004022 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198004023 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 264198004024 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 264198004025 META domain; Region: META; pfam03724 264198004026 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 264198004027 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 264198004028 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 264198004029 active site residue [active] 264198004030 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264198004031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198004032 S-adenosylmethionine binding site [chemical binding]; other site 264198004033 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198004034 Protein export membrane protein; Region: SecD_SecF; cl14618 264198004035 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264198004036 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198004037 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198004038 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198004039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198004040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198004041 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 264198004042 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 264198004043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198004044 S-adenosylmethionine binding site [chemical binding]; other site 264198004045 O-Antigen ligase; Region: Wzy_C; pfam04932 264198004046 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 264198004047 active site 264198004048 catalytic residues [active] 264198004049 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 264198004050 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 264198004051 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198004052 putative C-terminal domain interface [polypeptide binding]; other site 264198004053 putative GSH binding site (G-site) [chemical binding]; other site 264198004054 putative dimer interface [polypeptide binding]; other site 264198004055 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 264198004056 putative N-terminal domain interface [polypeptide binding]; other site 264198004057 putative dimer interface [polypeptide binding]; other site 264198004058 putative substrate binding pocket (H-site) [chemical binding]; other site 264198004059 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 264198004060 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 264198004061 acyl-activating enzyme (AAE) consensus motif; other site 264198004062 putative AMP binding site [chemical binding]; other site 264198004063 putative active site [active] 264198004064 putative CoA binding site [chemical binding]; other site 264198004065 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 264198004066 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264198004067 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198004068 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198004069 catalytic residue [active] 264198004070 aminotransferase; Validated; Region: PRK07337 264198004071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198004072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004073 homodimer interface [polypeptide binding]; other site 264198004074 catalytic residue [active] 264198004075 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 264198004076 putative RNA binding site [nucleotide binding]; other site 264198004077 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264198004078 homopentamer interface [polypeptide binding]; other site 264198004079 active site 264198004080 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 264198004081 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264198004082 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 264198004083 dimerization interface [polypeptide binding]; other site 264198004084 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198004085 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264198004086 putative CheW interface [polypeptide binding]; other site 264198004087 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 264198004088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198004089 TPR motif; other site 264198004090 binding surface 264198004091 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264198004092 Lumazine binding domain; Region: Lum_binding; pfam00677 264198004093 Lumazine binding domain; Region: Lum_binding; pfam00677 264198004094 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 264198004095 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264198004096 catalytic motif [active] 264198004097 Zn binding site [ion binding]; other site 264198004098 RibD C-terminal domain; Region: RibD_C; cl17279 264198004099 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 264198004100 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 264198004101 Type II transport protein GspH; Region: GspH; pfam12019 264198004102 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264198004103 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 264198004104 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 264198004105 Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681 264198004106 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264198004107 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 264198004108 Type II transport protein GspH; Region: GspH; pfam12019 264198004109 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 264198004110 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264198004111 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 264198004112 PilX N-terminal; Region: PilX_N; pfam14341 264198004113 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 264198004114 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 264198004115 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264198004116 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 264198004117 ATP cone domain; Region: ATP-cone; pfam03477 264198004118 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264198004119 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264198004120 dimer interface [polypeptide binding]; other site 264198004121 active site 264198004122 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264198004123 folate binding site [chemical binding]; other site 264198004124 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198004125 active site 264198004126 TolQ protein; Region: tolQ; TIGR02796 264198004127 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264198004128 TolR protein; Region: tolR; TIGR02801 264198004129 TolA protein; Region: tolA_full; TIGR02794 264198004130 TonB C terminal; Region: TonB_2; pfam13103 264198004131 translocation protein TolB; Provisional; Region: tolB; PRK02889 264198004132 TolB amino-terminal domain; Region: TolB_N; pfam04052 264198004133 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198004134 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198004135 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198004136 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198004137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198004138 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198004139 ligand binding site [chemical binding]; other site 264198004140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 264198004141 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 264198004142 Ligand Binding Site [chemical binding]; other site 264198004143 Predicted transporter component [General function prediction only]; Region: COG2391 264198004144 Sulphur transport; Region: Sulf_transp; pfam04143 264198004145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198004146 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264198004147 putative active site [active] 264198004148 heme pocket [chemical binding]; other site 264198004149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198004150 putative active site [active] 264198004151 heme pocket [chemical binding]; other site 264198004152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198004153 metal binding site [ion binding]; metal-binding site 264198004154 active site 264198004155 I-site; other site 264198004156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198004157 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 264198004158 Predicted membrane protein [Function unknown]; Region: COG5393 264198004159 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 264198004160 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 264198004161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198004162 FAD binding site [chemical binding]; other site 264198004163 substrate binding pocket [chemical binding]; other site 264198004164 catalytic base [active] 264198004165 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198004166 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198004167 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 264198004168 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 264198004169 kynureninase; Region: kynureninase; TIGR01814 264198004170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198004171 catalytic residue [active] 264198004172 arylformamidase; Region: trp_arylform; TIGR03035 264198004173 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198004174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198004175 putative DNA binding site [nucleotide binding]; other site 264198004176 putative Zn2+ binding site [ion binding]; other site 264198004177 AsnC family; Region: AsnC_trans_reg; pfam01037 264198004178 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264198004179 methionine sulfoxide reductase A; Provisional; Region: PRK14054 264198004180 Protein of unknown function DUF72; Region: DUF72; pfam01904 264198004181 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 264198004182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198004183 S-adenosylmethionine binding site [chemical binding]; other site 264198004184 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 264198004185 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264198004186 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 264198004187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198004188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004190 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 264198004191 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264198004192 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 264198004193 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 264198004194 putative ATP binding site [chemical binding]; other site 264198004195 putative substrate interface [chemical binding]; other site 264198004196 AAA domain; Region: AAA_33; pfam13671 264198004197 RNA helicase; Region: RNA_helicase; pfam00910 264198004198 Hemerythrin; Region: Hemerythrin; cd12107 264198004199 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 264198004200 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 264198004201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198004202 catalytic residues [active] 264198004203 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 264198004204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198004205 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 264198004206 acyl-activating enzyme (AAE) consensus motif; other site 264198004207 putative AMP binding site [chemical binding]; other site 264198004208 putative active site [active] 264198004209 putative CoA binding site [chemical binding]; other site 264198004210 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198004211 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264198004212 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198004213 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 264198004214 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264198004215 putative active site pocket [active] 264198004216 dimerization interface [polypeptide binding]; other site 264198004217 putative catalytic residue [active] 264198004218 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264198004219 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264198004220 YaeQ protein; Region: YaeQ; pfam07152 264198004221 Uncharacterized conserved protein [Function unknown]; Region: COG2353 264198004222 Predicted membrane protein [Function unknown]; Region: COG3686 264198004223 S4 domain; Region: S4_2; pfam13275 264198004224 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 264198004225 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198004226 active site 264198004227 HIGH motif; other site 264198004228 nucleotide binding site [chemical binding]; other site 264198004229 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 264198004230 KMSKS motif; other site 264198004231 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 264198004232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198004233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198004234 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 264198004235 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 264198004236 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 264198004237 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 264198004238 PapC N-terminal domain; Region: PapC_N; pfam13954 264198004239 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264198004240 PapC C-terminal domain; Region: PapC_C; pfam13953 264198004241 putative chaperone protein EcpD; Provisional; Region: PRK09926 264198004242 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264198004243 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264198004244 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 264198004245 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 264198004246 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264198004247 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198004248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198004249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198004250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198004251 dimerization interface [polypeptide binding]; other site 264198004252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 264198004253 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264198004254 potassium/proton antiporter; Reviewed; Region: PRK05326 264198004255 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264198004256 TrkA-C domain; Region: TrkA_C; pfam02080 264198004257 Transporter associated domain; Region: CorC_HlyC; smart01091 264198004258 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198004259 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 264198004260 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198004261 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198004262 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264198004263 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 264198004264 motif 1; other site 264198004265 active site 264198004266 motif 2; other site 264198004267 motif 3; other site 264198004268 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264198004269 DHHA1 domain; Region: DHHA1; pfam02272 264198004270 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 264198004271 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264198004272 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264198004273 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 264198004274 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 264198004275 dimer interface [polypeptide binding]; other site 264198004276 active site residues [active] 264198004277 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 264198004278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198004279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198004280 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198004281 dimerization interface [polypeptide binding]; other site 264198004282 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 264198004283 active site 1 [active] 264198004284 dimer interface [polypeptide binding]; other site 264198004285 hexamer interface [polypeptide binding]; other site 264198004286 active site 2 [active] 264198004287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004288 putative substrate translocation pore; other site 264198004289 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198004290 aldolase II superfamily protein; Provisional; Region: PRK07044 264198004291 intersubunit interface [polypeptide binding]; other site 264198004292 active site 264198004293 Zn2+ binding site [ion binding]; other site 264198004294 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 264198004295 active site 1 [active] 264198004296 dimer interface [polypeptide binding]; other site 264198004297 hexamer interface [polypeptide binding]; other site 264198004298 active site 2 [active] 264198004299 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 264198004300 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 264198004301 tetramer interface [polypeptide binding]; other site 264198004302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004303 catalytic residue [active] 264198004304 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 264198004305 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 264198004306 nudix motif; other site 264198004307 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264198004308 CPxP motif; other site 264198004309 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 264198004310 active site 264198004311 tetramer interface; other site 264198004312 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264198004313 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264198004314 HIGH motif; other site 264198004315 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264198004316 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264198004317 active site 264198004318 KMSKS motif; other site 264198004319 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264198004320 tRNA binding surface [nucleotide binding]; other site 264198004321 anticodon binding site; other site 264198004322 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264198004323 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 264198004324 Part of AAA domain; Region: AAA_19; pfam13245 264198004325 Family description; Region: UvrD_C_2; pfam13538 264198004326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004327 D-galactonate transporter; Region: 2A0114; TIGR00893 264198004328 putative substrate translocation pore; other site 264198004329 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198004330 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198004331 acyl-activating enzyme (AAE) consensus motif; other site 264198004332 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 264198004333 putative AMP binding site [chemical binding]; other site 264198004334 putative active site [active] 264198004335 acyl-activating enzyme (AAE) consensus motif; other site 264198004336 putative CoA binding site [chemical binding]; other site 264198004337 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 264198004338 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 264198004339 putative catalytic cysteine [active] 264198004340 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198004341 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198004342 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198004343 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 264198004344 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 264198004345 putative active site [active] 264198004346 putative substrate binding site [chemical binding]; other site 264198004347 ATP binding site [chemical binding]; other site 264198004348 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 264198004349 DNA polymerase I; Provisional; Region: PRK05755 264198004350 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264198004351 active site 264198004352 metal binding site 1 [ion binding]; metal-binding site 264198004353 putative 5' ssDNA interaction site; other site 264198004354 metal binding site 3; metal-binding site 264198004355 metal binding site 2 [ion binding]; metal-binding site 264198004356 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264198004357 putative DNA binding site [nucleotide binding]; other site 264198004358 putative metal binding site [ion binding]; other site 264198004359 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 264198004360 active site 264198004361 catalytic site [active] 264198004362 substrate binding site [chemical binding]; other site 264198004363 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264198004364 active site 264198004365 DNA binding site [nucleotide binding] 264198004366 catalytic site [active] 264198004367 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264198004368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198004369 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198004370 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198004371 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 264198004372 ZIP Zinc transporter; Region: Zip; pfam02535 264198004373 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 264198004374 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 264198004375 active site residue [active] 264198004376 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 264198004377 active site residue [active] 264198004378 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198004379 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198004380 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198004381 [2Fe-2S] cluster binding site [ion binding]; other site 264198004382 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 264198004383 alpha subunit interface [polypeptide binding]; other site 264198004384 active site 264198004385 substrate binding site [chemical binding]; other site 264198004386 Fe binding site [ion binding]; other site 264198004387 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 264198004388 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264198004389 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264198004390 substrate binding pocket [chemical binding]; other site 264198004391 chain length determination region; other site 264198004392 substrate-Mg2+ binding site; other site 264198004393 catalytic residues [active] 264198004394 aspartate-rich region 1; other site 264198004395 active site lid residues [active] 264198004396 aspartate-rich region 2; other site 264198004397 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 264198004398 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 264198004399 TPP-binding site; other site 264198004400 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264198004401 PYR/PP interface [polypeptide binding]; other site 264198004402 dimer interface [polypeptide binding]; other site 264198004403 TPP binding site [chemical binding]; other site 264198004404 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198004405 putative GTP cyclohydrolase; Provisional; Region: PRK13674 264198004406 UGMP family protein; Validated; Region: PRK09604 264198004407 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 264198004408 HI0933-like protein; Region: HI0933_like; pfam03486 264198004409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198004410 Yqey-like protein; Region: YqeY; pfam09424 264198004411 DNA primase; Validated; Region: dnaG; PRK05667 264198004412 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264198004413 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264198004414 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264198004415 active site 264198004416 metal binding site [ion binding]; metal-binding site 264198004417 interdomain interaction site; other site 264198004418 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264198004419 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 264198004420 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264198004421 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264198004422 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198004423 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264198004424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198004425 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198004426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198004427 DNA binding residues [nucleotide binding] 264198004428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004429 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198004430 putative substrate translocation pore; other site 264198004431 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 264198004432 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198004433 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 264198004434 active site 264198004435 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198004436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198004437 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198004438 dimerization interface [polypeptide binding]; other site 264198004439 substrate binding pocket [chemical binding]; other site 264198004440 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 264198004441 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 264198004442 putative ligand binding site [chemical binding]; other site 264198004443 NAD binding site [chemical binding]; other site 264198004444 dimerization interface [polypeptide binding]; other site 264198004445 catalytic site [active] 264198004446 aldolase II superfamily protein; Provisional; Region: PRK07044 264198004447 intersubunit interface [polypeptide binding]; other site 264198004448 active site 264198004449 Zn2+ binding site [ion binding]; other site 264198004450 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198004451 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004452 ligand binding site [chemical binding]; other site 264198004453 flexible hinge region; other site 264198004454 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 264198004455 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 264198004456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198004457 DNA-binding site [nucleotide binding]; DNA binding site 264198004458 UTRA domain; Region: UTRA; pfam07702 264198004459 urocanate hydratase; Provisional; Region: PRK05414 264198004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004461 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198004462 putative substrate translocation pore; other site 264198004463 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198004464 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264198004465 ATP binding site [chemical binding]; other site 264198004466 Mg++ binding site [ion binding]; other site 264198004467 motif III; other site 264198004468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198004469 nucleotide binding region [chemical binding]; other site 264198004470 ATP-binding site [chemical binding]; other site 264198004471 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 264198004472 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 264198004473 active site 264198004474 HIGH motif; other site 264198004475 nucleotide binding site [chemical binding]; other site 264198004476 active site 264198004477 KMSKS motif; other site 264198004478 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 264198004479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198004480 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 264198004481 putative dimerization interface [polypeptide binding]; other site 264198004482 Pirin-related protein [General function prediction only]; Region: COG1741 264198004483 Pirin; Region: Pirin; pfam02678 264198004484 CobD/CbiB family protein; Provisional; Region: PRK07630 264198004485 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 264198004486 GTPase RsgA; Reviewed; Region: PRK00098 264198004487 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 264198004488 RNA binding site [nucleotide binding]; other site 264198004489 homodimer interface [polypeptide binding]; other site 264198004490 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264198004491 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264198004492 GTP/Mg2+ binding site [chemical binding]; other site 264198004493 G4 box; other site 264198004494 G5 box; other site 264198004495 G1 box; other site 264198004496 Switch I region; other site 264198004497 G2 box; other site 264198004498 G3 box; other site 264198004499 Switch II region; other site 264198004500 Peptidase family M48; Region: Peptidase_M48; pfam01435 264198004501 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 264198004502 catalytic site [active] 264198004503 putative active site [active] 264198004504 putative substrate binding site [chemical binding]; other site 264198004505 dimer interface [polypeptide binding]; other site 264198004506 Predicted permeases [General function prediction only]; Region: COG0679 264198004507 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 264198004508 MPT binding site; other site 264198004509 trimer interface [polypeptide binding]; other site 264198004510 hypothetical protein; Provisional; Region: PRK05255 264198004511 peptidase PmbA; Provisional; Region: PRK11040 264198004512 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264198004513 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 264198004514 folate binding site [chemical binding]; other site 264198004515 NADP+ binding site [chemical binding]; other site 264198004516 thymidylate synthase; Reviewed; Region: thyA; PRK01827 264198004517 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 264198004518 dimerization interface [polypeptide binding]; other site 264198004519 active site 264198004520 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 264198004521 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 264198004522 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 264198004523 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 264198004524 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264198004525 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 264198004526 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198004527 ATP binding site [chemical binding]; other site 264198004528 Mg++ binding site [ion binding]; other site 264198004529 motif III; other site 264198004530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198004531 nucleotide binding region [chemical binding]; other site 264198004532 ATP-binding site [chemical binding]; other site 264198004533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264198004534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264198004535 active site 264198004536 ATP binding site [chemical binding]; other site 264198004537 substrate binding site [chemical binding]; other site 264198004538 activation loop (A-loop); other site 264198004539 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 264198004540 Uncharacterized conserved protein [Function unknown]; Region: COG1262 264198004541 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264198004542 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 264198004543 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 264198004544 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198004545 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264198004546 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264198004547 phosphopeptide binding site; other site 264198004548 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264198004549 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264198004550 phosphopeptide binding site; other site 264198004551 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264198004552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198004553 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198004554 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264198004555 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198004556 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004557 ligand binding site [chemical binding]; other site 264198004558 flexible hinge region; other site 264198004559 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004560 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198004561 ligand binding site [chemical binding]; other site 264198004562 flexible hinge region; other site 264198004563 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 264198004564 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 264198004565 putative active site [active] 264198004566 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264198004567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198004568 Walker A/P-loop; other site 264198004569 ATP binding site [chemical binding]; other site 264198004570 Q-loop/lid; other site 264198004571 ABC transporter signature motif; other site 264198004572 Walker B; other site 264198004573 D-loop; other site 264198004574 H-loop/switch region; other site 264198004575 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198004576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198004577 Walker A motif; other site 264198004578 ATP binding site [chemical binding]; other site 264198004579 Walker B motif; other site 264198004580 arginine finger; other site 264198004581 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 264198004582 PBP superfamily domain; Region: PBP_like_2; pfam12849 264198004583 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 264198004584 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 264198004585 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 264198004586 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 264198004587 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 264198004588 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 264198004589 apolar tunnel; other site 264198004590 heme binding site [chemical binding]; other site 264198004591 dimerization interface [polypeptide binding]; other site 264198004592 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 264198004593 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264198004594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198004595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198004596 Bacterial transcriptional repressor; Region: TetR; pfam13972 264198004597 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 264198004598 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198004599 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 264198004600 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198004601 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264198004602 putative active site [active] 264198004603 putative metal binding site [ion binding]; other site 264198004604 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198004605 PGAP1-like protein; Region: PGAP1; pfam07819 264198004606 RDD family; Region: RDD; pfam06271 264198004607 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 264198004608 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 264198004609 RNA polymerase factor sigma-70; Validated; Region: PRK09047 264198004610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198004611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198004612 DNA binding residues [nucleotide binding] 264198004613 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 264198004614 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198004615 PYR/PP interface [polypeptide binding]; other site 264198004616 dimer interface [polypeptide binding]; other site 264198004617 TPP binding site [chemical binding]; other site 264198004618 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198004619 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264198004620 TPP-binding site [chemical binding]; other site 264198004621 dimer interface [polypeptide binding]; other site 264198004622 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 264198004623 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 264198004624 putative valine binding site [chemical binding]; other site 264198004625 dimer interface [polypeptide binding]; other site 264198004626 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 264198004627 ketol-acid reductoisomerase; Provisional; Region: PRK05479 264198004628 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 264198004629 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 264198004630 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 264198004631 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264198004632 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264198004633 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 264198004634 BON domain; Region: BON; pfam04972 264198004635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198004636 2-isopropylmalate synthase; Validated; Region: PRK00915 264198004637 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 264198004638 active site 264198004639 catalytic residues [active] 264198004640 metal binding site [ion binding]; metal-binding site 264198004641 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 264198004642 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198004643 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198004644 putative ligand binding site [chemical binding]; other site 264198004645 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264198004646 16S/18S rRNA binding site [nucleotide binding]; other site 264198004647 S13e-L30e interaction site [polypeptide binding]; other site 264198004648 25S rRNA binding site [nucleotide binding]; other site 264198004649 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264198004650 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264198004651 RNase E interface [polypeptide binding]; other site 264198004652 trimer interface [polypeptide binding]; other site 264198004653 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264198004654 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264198004655 RNase E interface [polypeptide binding]; other site 264198004656 trimer interface [polypeptide binding]; other site 264198004657 active site 264198004658 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264198004659 putative nucleic acid binding region [nucleotide binding]; other site 264198004660 G-X-X-G motif; other site 264198004661 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264198004662 RNA binding site [nucleotide binding]; other site 264198004663 domain interface; other site 264198004664 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198004665 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 264198004666 NAD(P) binding site [chemical binding]; other site 264198004667 triosephosphate isomerase; Provisional; Region: PRK14567 264198004668 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264198004669 substrate binding site [chemical binding]; other site 264198004670 dimer interface [polypeptide binding]; other site 264198004671 catalytic triad [active] 264198004672 Preprotein translocase SecG subunit; Region: SecG; pfam03840 264198004673 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 264198004674 NADH dehydrogenase subunit B; Validated; Region: PRK06411 264198004675 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 264198004676 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 264198004677 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 264198004678 NADH dehydrogenase subunit D; Validated; Region: PRK06075 264198004679 NADH dehydrogenase subunit E; Validated; Region: PRK07539 264198004680 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264198004681 putative dimer interface [polypeptide binding]; other site 264198004682 [2Fe-2S] cluster binding site [ion binding]; other site 264198004683 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198004684 SLBB domain; Region: SLBB; pfam10531 264198004685 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 264198004686 NADH dehydrogenase subunit G; Validated; Region: PRK09129 264198004687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198004688 catalytic loop [active] 264198004689 iron binding site [ion binding]; other site 264198004690 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264198004691 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 264198004692 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 264198004693 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 264198004694 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 264198004695 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 264198004696 4Fe-4S binding domain; Region: Fer4; pfam00037 264198004697 4Fe-4S binding domain; Region: Fer4; pfam00037 264198004698 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 264198004699 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 264198004700 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 264198004701 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264198004702 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264198004703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264198004704 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264198004705 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264198004706 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264198004707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264198004708 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 264198004709 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 264198004710 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264198004711 dimer interface [polypeptide binding]; other site 264198004712 ADP-ribose binding site [chemical binding]; other site 264198004713 active site 264198004714 nudix motif; other site 264198004715 metal binding site [ion binding]; metal-binding site 264198004716 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 264198004717 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198004718 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198004719 FAD binding site [chemical binding]; other site 264198004720 substrate binding site [chemical binding]; other site 264198004721 catalytic base [active] 264198004722 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198004723 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198004724 active site 264198004725 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 264198004726 putative active site [active] 264198004727 putative catalytic site [active] 264198004728 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198004729 putative active site [active] 264198004730 putative catalytic site [active] 264198004731 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 264198004732 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198004733 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264198004734 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198004735 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264198004736 D-pathway; other site 264198004737 Putative ubiquinol binding site [chemical binding]; other site 264198004738 Low-spin heme (heme b) binding site [chemical binding]; other site 264198004739 Putative water exit pathway; other site 264198004740 Binuclear center (heme o3/CuB) [ion binding]; other site 264198004741 K-pathway; other site 264198004742 Putative proton exit pathway; other site 264198004743 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264198004744 Subunit I/III interface [polypeptide binding]; other site 264198004745 Subunit III/IV interface [polypeptide binding]; other site 264198004746 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 264198004747 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198004748 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 264198004749 putative ligand binding site [chemical binding]; other site 264198004750 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198004751 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198004752 TM-ABC transporter signature motif; other site 264198004753 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198004754 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198004755 TM-ABC transporter signature motif; other site 264198004756 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 264198004757 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198004758 Walker A/P-loop; other site 264198004759 ATP binding site [chemical binding]; other site 264198004760 Q-loop/lid; other site 264198004761 ABC transporter signature motif; other site 264198004762 Walker B; other site 264198004763 D-loop; other site 264198004764 H-loop/switch region; other site 264198004765 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 264198004766 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198004767 Walker A/P-loop; other site 264198004768 ATP binding site [chemical binding]; other site 264198004769 Q-loop/lid; other site 264198004770 ABC transporter signature motif; other site 264198004771 Walker B; other site 264198004772 D-loop; other site 264198004773 H-loop/switch region; other site 264198004774 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 264198004775 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 264198004776 alpha-gamma subunit interface [polypeptide binding]; other site 264198004777 beta-gamma subunit interface [polypeptide binding]; other site 264198004778 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 264198004779 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 264198004780 gamma-beta subunit interface [polypeptide binding]; other site 264198004781 alpha-beta subunit interface [polypeptide binding]; other site 264198004782 urease subunit alpha; Reviewed; Region: ureC; PRK13207 264198004783 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 264198004784 subunit interactions [polypeptide binding]; other site 264198004785 active site 264198004786 flap region; other site 264198004787 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 264198004788 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 264198004789 dimer interface [polypeptide binding]; other site 264198004790 catalytic residues [active] 264198004791 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 264198004792 UreF; Region: UreF; pfam01730 264198004793 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198004794 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198004795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198004796 non-specific DNA binding site [nucleotide binding]; other site 264198004797 salt bridge; other site 264198004798 sequence-specific DNA binding site [nucleotide binding]; other site 264198004799 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 264198004800 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264198004801 C-terminal domain interface [polypeptide binding]; other site 264198004802 GSH binding site (G-site) [chemical binding]; other site 264198004803 dimer interface [polypeptide binding]; other site 264198004804 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 264198004805 N-terminal domain interface [polypeptide binding]; other site 264198004806 putative dimer interface [polypeptide binding]; other site 264198004807 active site 264198004808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198004809 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 264198004810 FAD binding site [chemical binding]; other site 264198004811 substrate binding site [chemical binding]; other site 264198004812 catalytic base [active] 264198004813 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198004814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198004815 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 264198004816 substrate binding pocket [chemical binding]; other site 264198004817 dimerization interface [polypeptide binding]; other site 264198004818 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264198004819 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 264198004820 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264198004821 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198004822 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198004823 Phosphotransferase enzyme family; Region: APH; pfam01636 264198004824 putative active site [active] 264198004825 putative substrate binding site [chemical binding]; other site 264198004826 ATP binding site [chemical binding]; other site 264198004827 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198004828 catalytic core [active] 264198004829 enoyl-CoA hydratase; Provisional; Region: PRK07511 264198004830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198004831 substrate binding site [chemical binding]; other site 264198004832 oxyanion hole (OAH) forming residues; other site 264198004833 trimer interface [polypeptide binding]; other site 264198004834 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 264198004835 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198004836 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198004837 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198004838 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198004839 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 264198004840 C-terminal domain interface [polypeptide binding]; other site 264198004841 GSH binding site (G-site) [chemical binding]; other site 264198004842 dimer interface [polypeptide binding]; other site 264198004843 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 264198004844 putative N-terminal domain interface [polypeptide binding]; other site 264198004845 putative dimer interface [polypeptide binding]; other site 264198004846 putative substrate binding pocket (H-site) [chemical binding]; other site 264198004847 methionine aminotransferase; Validated; Region: PRK09082 264198004848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198004849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004850 homodimer interface [polypeptide binding]; other site 264198004851 catalytic residue [active] 264198004852 PIN domain; Region: PIN_3; pfam13470 264198004853 hypothetical protein; Validated; Region: PRK02101 264198004854 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 264198004855 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 264198004856 putative active site [active] 264198004857 Zn binding site [ion binding]; other site 264198004858 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 264198004859 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198004860 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198004861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198004862 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 264198004863 dimerization interface [polypeptide binding]; other site 264198004864 substrate binding pocket [chemical binding]; other site 264198004865 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 264198004866 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198004867 putative ligand binding site [chemical binding]; other site 264198004868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 264198004869 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264198004870 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198004871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198004872 Walker A motif; other site 264198004873 ATP binding site [chemical binding]; other site 264198004874 Walker B motif; other site 264198004875 arginine finger; other site 264198004876 Cytochrome c553 [Energy production and conversion]; Region: COG2863 264198004877 Cytochrome c; Region: Cytochrom_C; cl11414 264198004878 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 264198004879 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264198004880 protease TldD; Provisional; Region: tldD; PRK10735 264198004881 nitrilase; Region: PLN02798 264198004882 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 264198004883 putative active site [active] 264198004884 catalytic triad [active] 264198004885 dimer interface [polypeptide binding]; other site 264198004886 Predicted membrane protein [Function unknown]; Region: COG3164 264198004887 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264198004888 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 264198004889 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264198004890 metal binding triad; other site 264198004891 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264198004892 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264198004893 metal binding triad; other site 264198004894 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264198004895 Rhomboid family; Region: Rhomboid; cl11446 264198004896 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 264198004897 active site 264198004898 catalytic triad [active] 264198004899 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264198004900 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264198004901 Walker A/P-loop; other site 264198004902 ATP binding site [chemical binding]; other site 264198004903 Q-loop/lid; other site 264198004904 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264198004905 ABC transporter signature motif; other site 264198004906 Walker B; other site 264198004907 D-loop; other site 264198004908 H-loop/switch region; other site 264198004909 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 264198004910 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 264198004911 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 264198004912 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 264198004913 ferrochelatase; Reviewed; Region: hemH; PRK00035 264198004914 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 264198004915 C-terminal domain interface [polypeptide binding]; other site 264198004916 active site 264198004917 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 264198004918 active site 264198004919 N-terminal domain interface [polypeptide binding]; other site 264198004920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198004921 RNA binding surface [nucleotide binding]; other site 264198004922 GrpE; Region: GrpE; pfam01025 264198004923 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264198004924 dimer interface [polypeptide binding]; other site 264198004925 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264198004926 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198004927 catalytic residues [active] 264198004928 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 264198004929 dimerization interface [polypeptide binding]; other site 264198004930 substrate binding site [chemical binding]; other site 264198004931 active site 264198004932 calcium binding site [ion binding]; other site 264198004933 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 264198004934 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 264198004935 putative FMN binding site [chemical binding]; other site 264198004936 endonuclease III; Provisional; Region: PRK10702 264198004937 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198004938 minor groove reading motif; other site 264198004939 helix-hairpin-helix signature motif; other site 264198004940 substrate binding pocket [chemical binding]; other site 264198004941 active site 264198004942 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 264198004943 ferredoxin; Provisional; Region: PRK06991 264198004944 Putative Fe-S cluster; Region: FeS; pfam04060 264198004945 4Fe-4S binding domain; Region: Fer4; pfam00037 264198004946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198004947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198004948 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 264198004949 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 264198004950 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264198004951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198004952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004953 homodimer interface [polypeptide binding]; other site 264198004954 catalytic residue [active] 264198004955 excinuclease ABC subunit B; Provisional; Region: PRK05298 264198004956 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 264198004957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198004958 ATP-binding site [chemical binding]; other site 264198004959 ATP binding site [chemical binding]; other site 264198004960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198004961 nucleotide binding region [chemical binding]; other site 264198004962 ATP-binding site [chemical binding]; other site 264198004963 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264198004964 UvrB/uvrC motif; Region: UVR; pfam02151 264198004965 Site-specific recombinase; Region: SpecificRecomb; pfam10136 264198004966 Predicted transcriptional regulator [Transcription]; Region: COG1959 264198004967 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 264198004968 cysteine desulfurase; Provisional; Region: PRK14012 264198004969 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264198004970 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198004971 catalytic residue [active] 264198004972 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 264198004973 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264198004974 trimerization site [polypeptide binding]; other site 264198004975 active site 264198004976 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 264198004977 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 264198004978 co-chaperone HscB; Provisional; Region: hscB; PRK03578 264198004979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198004980 HSP70 interaction site [polypeptide binding]; other site 264198004981 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 264198004982 chaperone protein HscA; Provisional; Region: hscA; PRK05183 264198004983 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 264198004984 nucleotide binding site [chemical binding]; other site 264198004985 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264198004986 SBD interface [polypeptide binding]; other site 264198004987 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264198004988 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198004989 catalytic loop [active] 264198004990 iron binding site [ion binding]; other site 264198004991 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 264198004992 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 264198004993 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 264198004994 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 264198004995 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 264198004996 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 264198004997 Walker A/P-loop; other site 264198004998 ATP binding site [chemical binding]; other site 264198004999 Q-loop/lid; other site 264198005000 ABC transporter signature motif; other site 264198005001 Walker B; other site 264198005002 D-loop; other site 264198005003 H-loop/switch region; other site 264198005004 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264198005005 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264198005006 dimer interface [polypeptide binding]; other site 264198005007 putative anticodon binding site; other site 264198005008 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264198005009 motif 1; other site 264198005010 active site 264198005011 motif 2; other site 264198005012 motif 3; other site 264198005013 short chain dehydrogenase; Provisional; Region: PRK07023 264198005014 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 264198005015 NADP binding site [chemical binding]; other site 264198005016 homodimer interface [polypeptide binding]; other site 264198005017 active site 264198005018 peptide chain release factor 2; Validated; Region: prfB; PRK00578 264198005019 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264198005020 RF-1 domain; Region: RF-1; pfam00472 264198005021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198005022 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198005023 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 264198005024 DHH family; Region: DHH; pfam01368 264198005025 DHHA1 domain; Region: DHHA1; pfam02272 264198005026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 264198005027 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 264198005028 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198005029 FtsX-like permease family; Region: FtsX; pfam02687 264198005030 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 264198005031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264198005032 Walker A/P-loop; other site 264198005033 ATP binding site [chemical binding]; other site 264198005034 Q-loop/lid; other site 264198005035 ABC transporter signature motif; other site 264198005036 Walker B; other site 264198005037 D-loop; other site 264198005038 H-loop/switch region; other site 264198005039 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264198005040 active site 264198005041 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 264198005042 ComEC family competence protein; Provisional; Region: PRK11539 264198005043 Competence protein; Region: Competence; pfam03772 264198005044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198005045 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 264198005046 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198005047 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198005048 putative active site [active] 264198005049 phosphogluconate dehydratase; Validated; Region: PRK09054 264198005050 6-phosphogluconate dehydratase; Region: edd; TIGR01196 264198005051 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 264198005052 ATP-binding site [chemical binding]; other site 264198005053 Gluconate-6-phosphate binding site [chemical binding]; other site 264198005054 Shikimate kinase; Region: SKI; pfam01202 264198005055 Uncharacterized conserved protein [Function unknown]; Region: COG2308 264198005056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 264198005057 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 264198005058 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198005059 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264198005060 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264198005061 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 264198005062 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 264198005063 Thioesterase domain; Region: Thioesterase; pfam00975 264198005064 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 264198005065 nucleophilic elbow; other site 264198005066 catalytic triad; other site 264198005067 CTP synthetase; Validated; Region: pyrG; PRK05380 264198005068 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264198005069 Catalytic site [active] 264198005070 active site 264198005071 UTP binding site [chemical binding]; other site 264198005072 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264198005073 active site 264198005074 putative oxyanion hole; other site 264198005075 catalytic triad [active] 264198005076 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 264198005077 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264198005078 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 264198005079 enolase; Provisional; Region: eno; PRK00077 264198005080 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264198005081 dimer interface [polypeptide binding]; other site 264198005082 metal binding site [ion binding]; metal-binding site 264198005083 substrate binding pocket [chemical binding]; other site 264198005084 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 264198005085 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 264198005086 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 264198005087 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 264198005088 dimerization interface [polypeptide binding]; other site 264198005089 domain crossover interface; other site 264198005090 redox-dependent activation switch; other site 264198005091 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264198005092 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264198005093 trimer interface [polypeptide binding]; other site 264198005094 putative metal binding site [ion binding]; other site 264198005095 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198005096 dinuclear metal binding motif [ion binding]; other site 264198005097 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198005098 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 264198005099 active site 264198005100 acyl-activating enzyme (AAE) consensus motif; other site 264198005101 putative CoA binding site [chemical binding]; other site 264198005102 AMP binding site [chemical binding]; other site 264198005103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198005104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005105 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 264198005106 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198005107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198005108 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 264198005109 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264198005110 active site 264198005111 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264198005112 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 264198005113 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 264198005114 Peptidase family M50; Region: Peptidase_M50; pfam02163 264198005115 active site 264198005116 putative substrate binding region [chemical binding]; other site 264198005117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198005118 S-adenosylmethionine binding site [chemical binding]; other site 264198005119 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264198005120 dihydrodipicolinate synthase; Region: dapA; TIGR00674 264198005121 dimer interface [polypeptide binding]; other site 264198005122 active site 264198005123 catalytic residue [active] 264198005124 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 264198005125 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 264198005126 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 264198005127 Uncharacterized conserved protein [Function unknown]; Region: COG2850 264198005128 Cupin-like domain; Region: Cupin_8; pfam13621 264198005129 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264198005130 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264198005131 MutS domain I; Region: MutS_I; pfam01624 264198005132 MutS domain II; Region: MutS_II; pfam05188 264198005133 MutS domain III; Region: MutS_III; pfam05192 264198005134 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 264198005135 Walker A/P-loop; other site 264198005136 ATP binding site [chemical binding]; other site 264198005137 Q-loop/lid; other site 264198005138 ABC transporter signature motif; other site 264198005139 Walker B; other site 264198005140 D-loop; other site 264198005141 H-loop/switch region; other site 264198005142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005143 Ligand Binding Site [chemical binding]; other site 264198005144 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 264198005145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 264198005146 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264198005147 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 264198005148 active site 264198005149 dimerization interface [polypeptide binding]; other site 264198005150 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 264198005151 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 264198005152 serine O-acetyltransferase; Region: cysE; TIGR01172 264198005153 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264198005154 trimer interface [polypeptide binding]; other site 264198005155 active site 264198005156 substrate binding site [chemical binding]; other site 264198005157 CoA binding site [chemical binding]; other site 264198005158 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264198005159 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198005160 putative active site [active] 264198005161 putative metal binding site [ion binding]; other site 264198005162 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 264198005163 substrate binding site [chemical binding]; other site 264198005164 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 264198005165 substrate binding site [chemical binding]; other site 264198005166 TPR repeat; Region: TPR_11; pfam13414 264198005167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198005168 binding surface 264198005169 TPR motif; other site 264198005170 TPR repeat; Region: TPR_11; pfam13414 264198005171 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264198005172 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264198005173 active site 264198005174 HIGH motif; other site 264198005175 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264198005176 KMSKS motif; other site 264198005177 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 264198005178 tRNA binding surface [nucleotide binding]; other site 264198005179 anticodon binding site; other site 264198005180 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198005181 endonuclease III; Region: ENDO3c; smart00478 264198005182 minor groove reading motif; other site 264198005183 helix-hairpin-helix signature motif; other site 264198005184 substrate binding pocket [chemical binding]; other site 264198005185 active site 264198005186 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 264198005187 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 264198005188 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264198005189 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 264198005190 Ligand Binding Site [chemical binding]; other site 264198005191 TilS substrate binding domain; Region: TilS; pfam09179 264198005192 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 264198005193 aspartate kinase; Reviewed; Region: PRK06635 264198005194 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 264198005195 putative nucleotide binding site [chemical binding]; other site 264198005196 putative catalytic residues [active] 264198005197 putative Mg ion binding site [ion binding]; other site 264198005198 putative aspartate binding site [chemical binding]; other site 264198005199 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 264198005200 putative allosteric regulatory site; other site 264198005201 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 264198005202 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198005203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198005204 substrate binding pocket [chemical binding]; other site 264198005205 membrane-bound complex binding site; other site 264198005206 hinge residues; other site 264198005207 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264198005208 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264198005209 putative trimer interface [polypeptide binding]; other site 264198005210 putative CoA binding site [chemical binding]; other site 264198005211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198005212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198005213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198005214 dimerization interface [polypeptide binding]; other site 264198005215 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 264198005216 putative FMN binding site [chemical binding]; other site 264198005217 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198005218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198005219 active site 264198005220 metal binding site [ion binding]; metal-binding site 264198005221 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 264198005222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198005223 putative active site [active] 264198005224 putative metal binding site [ion binding]; other site 264198005225 YCII-related domain; Region: YCII; cl00999 264198005226 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198005227 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198005228 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 264198005229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198005230 putative metal binding site [ion binding]; other site 264198005231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198005232 dimerization interface [polypeptide binding]; other site 264198005233 putative DNA binding site [nucleotide binding]; other site 264198005234 putative Zn2+ binding site [ion binding]; other site 264198005235 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198005236 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005237 Ligand Binding Site [chemical binding]; other site 264198005238 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005239 Ligand Binding Site [chemical binding]; other site 264198005240 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005241 Ligand Binding Site [chemical binding]; other site 264198005242 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 264198005243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 264198005244 Beta-Casp domain; Region: Beta-Casp; smart01027 264198005245 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 264198005246 Response regulator receiver domain; Region: Response_reg; pfam00072 264198005247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005248 active site 264198005249 phosphorylation site [posttranslational modification] 264198005250 intermolecular recognition site; other site 264198005251 dimerization interface [polypeptide binding]; other site 264198005252 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198005253 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198005254 ligand binding site [chemical binding]; other site 264198005255 flexible hinge region; other site 264198005256 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198005257 putative switch regulator; other site 264198005258 non-specific DNA interactions [nucleotide binding]; other site 264198005259 DNA binding site [nucleotide binding] 264198005260 sequence specific DNA binding site [nucleotide binding]; other site 264198005261 putative cAMP binding site [chemical binding]; other site 264198005262 Response regulator receiver domain; Region: Response_reg; pfam00072 264198005263 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264198005264 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 264198005265 putative dimer interface [polypeptide binding]; other site 264198005266 FOG: CBS domain [General function prediction only]; Region: COG0517 264198005267 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 264198005268 BON domain; Region: BON; pfam04972 264198005269 BON domain; Region: BON; pfam04972 264198005270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 264198005271 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 264198005272 putative FMN binding site [chemical binding]; other site 264198005273 NADPH bind site [chemical binding]; other site 264198005274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198005275 active site 264198005276 Rhomboid family; Region: Rhomboid; pfam01694 264198005277 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198005278 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 264198005279 phosphoenolpyruvate synthase; Validated; Region: PRK06464 264198005280 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264198005281 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 264198005282 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264198005283 purine nucleoside phosphorylase; Provisional; Region: PRK08202 264198005284 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005285 Ligand Binding Site [chemical binding]; other site 264198005286 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005287 Ligand Binding Site [chemical binding]; other site 264198005288 GYD domain; Region: GYD; cl01743 264198005289 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264198005290 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 264198005291 hexamer interface [polypeptide binding]; other site 264198005292 ligand binding site [chemical binding]; other site 264198005293 putative active site [active] 264198005294 NAD(P) binding site [chemical binding]; other site 264198005295 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 264198005296 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 264198005297 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198005298 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 264198005299 dimer interface [polypeptide binding]; other site 264198005300 putative inhibitory loop; other site 264198005301 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198005302 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198005303 trimer interface [polypeptide binding]; other site 264198005304 eyelet of channel; other site 264198005305 ribonuclease Z; Provisional; Region: PRK02126 264198005306 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 264198005307 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 264198005308 substrate binding site [chemical binding]; other site 264198005309 FMN-binding domain; Region: FMN_bind; pfam04205 264198005310 ApbE family; Region: ApbE; pfam02424 264198005311 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 264198005312 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 264198005313 Rhodanese-like domain; Region: Rhodanese; pfam00581 264198005314 active site residue [active] 264198005315 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 264198005316 active site residue [active] 264198005317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005318 Ligand Binding Site [chemical binding]; other site 264198005319 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 264198005320 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 264198005321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198005322 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264198005323 Cytochrome c [Energy production and conversion]; Region: COG3258 264198005324 Cytochrome c; Region: Cytochrom_C; pfam00034 264198005325 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264198005326 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 264198005327 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198005328 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198005329 classical (c) SDRs; Region: SDR_c; cd05233 264198005330 NAD(P) binding site [chemical binding]; other site 264198005331 active site 264198005332 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264198005333 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264198005334 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198005335 active site 264198005336 oxalacetate binding site [chemical binding]; other site 264198005337 citrylCoA binding site [chemical binding]; other site 264198005338 coenzyme A binding site [chemical binding]; other site 264198005339 catalytic triad [active] 264198005340 short chain dehydrogenase; Provisional; Region: PRK07577 264198005341 classical (c) SDRs; Region: SDR_c; cd05233 264198005342 NAD(P) binding site [chemical binding]; other site 264198005343 active site 264198005344 acyl-CoA synthetase; Validated; Region: PRK06188 264198005345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198005346 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198005347 acyl-activating enzyme (AAE) consensus motif; other site 264198005348 acyl-activating enzyme (AAE) consensus motif; other site 264198005349 putative AMP binding site [chemical binding]; other site 264198005350 putative active site [active] 264198005351 putative CoA binding site [chemical binding]; other site 264198005352 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198005353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198005354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198005355 DNA binding site [nucleotide binding] 264198005356 domain linker motif; other site 264198005357 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 264198005358 putative dimerization interface [polypeptide binding]; other site 264198005359 putative ligand binding site [chemical binding]; other site 264198005360 Predicted membrane protein [Function unknown]; Region: COG2259 264198005361 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 264198005362 phosphate acetyltransferase; Provisional; Region: PRK11890 264198005363 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 264198005364 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 264198005365 propionate/acetate kinase; Provisional; Region: PRK12379 264198005366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005367 Ligand Binding Site [chemical binding]; other site 264198005368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005369 Ligand Binding Site [chemical binding]; other site 264198005370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 264198005371 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 264198005372 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198005373 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264198005374 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264198005375 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198005376 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 264198005377 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198005378 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198005379 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005380 Ligand Binding Site [chemical binding]; other site 264198005381 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 264198005382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198005383 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 264198005384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264198005385 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264198005386 PAS domain S-box; Region: sensory_box; TIGR00229 264198005387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005388 putative active site [active] 264198005389 heme pocket [chemical binding]; other site 264198005390 PAS domain S-box; Region: sensory_box; TIGR00229 264198005391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005392 putative active site [active] 264198005393 heme pocket [chemical binding]; other site 264198005394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264198005395 Histidine kinase; Region: HisKA_3; pfam07730 264198005396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005397 ATP binding site [chemical binding]; other site 264198005398 Mg2+ binding site [ion binding]; other site 264198005399 G-X-G motif; other site 264198005400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198005401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005402 active site 264198005403 phosphorylation site [posttranslational modification] 264198005404 intermolecular recognition site; other site 264198005405 dimerization interface [polypeptide binding]; other site 264198005406 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198005407 DNA binding residues [nucleotide binding] 264198005408 dimerization interface [polypeptide binding]; other site 264198005409 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198005410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198005411 ligand binding site [chemical binding]; other site 264198005412 flexible hinge region; other site 264198005413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198005414 putative switch regulator; other site 264198005415 non-specific DNA interactions [nucleotide binding]; other site 264198005416 DNA binding site [nucleotide binding] 264198005417 sequence specific DNA binding site [nucleotide binding]; other site 264198005418 putative cAMP binding site [chemical binding]; other site 264198005419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198005420 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264198005421 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 264198005422 putative dimer interface [polypeptide binding]; other site 264198005423 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198005424 BON domain; Region: BON; pfam04972 264198005425 BON domain; Region: BON; pfam04972 264198005426 BON domain; Region: BON; pfam04972 264198005427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 264198005428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198005429 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264198005430 FtsX-like permease family; Region: FtsX; pfam02687 264198005431 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264198005432 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264198005433 Walker A/P-loop; other site 264198005434 ATP binding site [chemical binding]; other site 264198005435 Q-loop/lid; other site 264198005436 ABC transporter signature motif; other site 264198005437 Walker B; other site 264198005438 D-loop; other site 264198005439 H-loop/switch region; other site 264198005440 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198005441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198005442 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198005443 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198005444 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198005445 BON domain; Region: BON; pfam04972 264198005446 BON domain; Region: BON; pfam04972 264198005447 BON domain; Region: BON; pfam04972 264198005448 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 264198005449 putative FMN binding site [chemical binding]; other site 264198005450 NADPH bind site [chemical binding]; other site 264198005451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 264198005452 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264198005453 AAA domain; Region: AAA_33; pfam13671 264198005454 active site 264198005455 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198005456 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 264198005457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198005458 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264198005459 Hemerythrin-like domain; Region: Hr-like; cd12108 264198005460 Fe binding site [ion binding]; other site 264198005461 BON domain; Region: BON; pfam04972 264198005462 Protein required for attachment to host cells; Region: Host_attach; pfam10116 264198005463 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 264198005464 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 264198005465 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198005466 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198005467 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198005468 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264198005469 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264198005470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264198005471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198005472 dimer interface [polypeptide binding]; other site 264198005473 conserved gate region; other site 264198005474 putative PBP binding loops; other site 264198005475 ABC-ATPase subunit interface; other site 264198005476 dipeptide transporter; Provisional; Region: PRK10913 264198005477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198005478 putative PBP binding loops; other site 264198005479 dimer interface [polypeptide binding]; other site 264198005480 ABC-ATPase subunit interface; other site 264198005481 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264198005482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198005483 Walker A/P-loop; other site 264198005484 ATP binding site [chemical binding]; other site 264198005485 Q-loop/lid; other site 264198005486 ABC transporter signature motif; other site 264198005487 Walker B; other site 264198005488 D-loop; other site 264198005489 H-loop/switch region; other site 264198005490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264198005491 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 264198005492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198005493 Walker A/P-loop; other site 264198005494 ATP binding site [chemical binding]; other site 264198005495 Q-loop/lid; other site 264198005496 ABC transporter signature motif; other site 264198005497 Walker B; other site 264198005498 D-loop; other site 264198005499 H-loop/switch region; other site 264198005500 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264198005501 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198005502 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198005503 eyelet of channel; other site 264198005504 trimer interface [polypeptide binding]; other site 264198005505 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 264198005506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198005507 FAD binding domain; Region: FAD_binding_4; pfam01565 264198005508 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 264198005509 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198005510 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198005511 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 264198005512 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 264198005513 Protein of unknown function (DUF962); Region: DUF962; cl01879 264198005514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198005516 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 264198005517 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 264198005518 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198005519 homodimer interface [polypeptide binding]; other site 264198005520 substrate-cofactor binding pocket; other site 264198005521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198005522 catalytic residue [active] 264198005523 FOG: CBS domain [General function prediction only]; Region: COG0517 264198005524 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 264198005525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198005527 putative acyl-acceptor binding pocket; other site 264198005528 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 264198005529 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198005530 putative C-terminal domain interface [polypeptide binding]; other site 264198005531 putative GSH binding site [chemical binding]; other site 264198005532 putative dimer interface [polypeptide binding]; other site 264198005533 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 264198005534 putative N-terminal domain interface [polypeptide binding]; other site 264198005535 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 264198005536 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264198005537 Tetramer interface [polypeptide binding]; other site 264198005538 active site 264198005539 FMN-binding site [chemical binding]; other site 264198005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005541 putative substrate translocation pore; other site 264198005542 Predicted dehydrogenase [General function prediction only]; Region: COG0579 264198005543 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264198005544 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198005545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198005546 DNA-binding site [nucleotide binding]; DNA binding site 264198005547 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264198005548 Flagellar protein YcgR; Region: YcgR_2; pfam12945 264198005549 PilZ domain; Region: PilZ; pfam07238 264198005550 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 264198005551 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264198005552 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 264198005553 short chain dehydrogenase; Provisional; Region: PRK06949 264198005554 classical (c) SDRs; Region: SDR_c; cd05233 264198005555 NAD(P) binding site [chemical binding]; other site 264198005556 active site 264198005557 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 264198005558 DctM-like transporters; Region: DctM; pfam06808 264198005559 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 264198005560 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264198005561 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 264198005562 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198005563 active site 264198005564 PAS domain; Region: PAS_9; pfam13426 264198005565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005566 putative active site [active] 264198005567 heme pocket [chemical binding]; other site 264198005568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198005569 DNA binding residues [nucleotide binding] 264198005570 dimerization interface [polypeptide binding]; other site 264198005571 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 264198005572 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 264198005573 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 264198005574 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 264198005575 NAD binding site [chemical binding]; other site 264198005576 homotetramer interface [polypeptide binding]; other site 264198005577 homodimer interface [polypeptide binding]; other site 264198005578 substrate binding site [chemical binding]; other site 264198005579 active site 264198005580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198005581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198005582 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 264198005583 homotrimer interaction site [polypeptide binding]; other site 264198005584 putative active site [active] 264198005585 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264198005586 HD domain; Region: HD_4; pfam13328 264198005587 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264198005588 synthetase active site [active] 264198005589 NTP binding site [chemical binding]; other site 264198005590 metal binding site [ion binding]; metal-binding site 264198005591 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264198005592 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264198005593 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264198005594 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264198005595 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264198005596 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264198005597 active site 264198005598 dimer interface [polypeptide binding]; other site 264198005599 motif 1; other site 264198005600 motif 2; other site 264198005601 motif 3; other site 264198005602 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264198005603 anticodon binding site; other site 264198005604 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 264198005605 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264198005606 23S rRNA binding site [nucleotide binding]; other site 264198005607 L21 binding site [polypeptide binding]; other site 264198005608 L13 binding site [polypeptide binding]; other site 264198005609 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264198005610 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264198005611 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264198005612 dimer interface [polypeptide binding]; other site 264198005613 motif 1; other site 264198005614 active site 264198005615 motif 2; other site 264198005616 motif 3; other site 264198005617 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264198005618 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264198005619 putative tRNA-binding site [nucleotide binding]; other site 264198005620 B3/4 domain; Region: B3_4; pfam03483 264198005621 tRNA synthetase B5 domain; Region: B5; smart00874 264198005622 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264198005623 dimer interface [polypeptide binding]; other site 264198005624 motif 1; other site 264198005625 motif 3; other site 264198005626 motif 2; other site 264198005627 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 264198005628 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198005629 IHF - DNA interface [nucleotide binding]; other site 264198005630 IHF dimer interface [polypeptide binding]; other site 264198005631 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 264198005632 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264198005633 DNA binding residues [nucleotide binding] 264198005634 Uncharacterized conserved protein [Function unknown]; Region: COG3542 264198005635 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 264198005636 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 264198005637 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 264198005638 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 264198005639 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 264198005640 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198005641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198005642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198005643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198005644 dimerization interface [polypeptide binding]; other site 264198005645 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 264198005646 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264198005647 active site 264198005648 putative substrate binding pocket [chemical binding]; other site 264198005649 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198005650 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264198005651 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198005652 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264198005653 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198005654 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 264198005655 putative catalytic site [active] 264198005656 putative phosphate binding site [ion binding]; other site 264198005657 active site 264198005658 metal binding site A [ion binding]; metal-binding site 264198005659 DNA binding site [nucleotide binding] 264198005660 putative AP binding site [nucleotide binding]; other site 264198005661 putative metal binding site B [ion binding]; other site 264198005662 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 264198005663 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 264198005664 active site 264198005665 Zn binding site [ion binding]; other site 264198005666 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 264198005667 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264198005668 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264198005669 homodimer interface [polypeptide binding]; other site 264198005670 NADP binding site [chemical binding]; other site 264198005671 substrate binding site [chemical binding]; other site 264198005672 Predicted membrane protein [Function unknown]; Region: COG3235 264198005673 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 264198005674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005675 active site 264198005676 phosphorylation site [posttranslational modification] 264198005677 intermolecular recognition site; other site 264198005678 dimerization interface [polypeptide binding]; other site 264198005679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198005680 DNA binding residues [nucleotide binding] 264198005681 dimerization interface [polypeptide binding]; other site 264198005682 PAS domain S-box; Region: sensory_box; TIGR00229 264198005683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005684 putative active site [active] 264198005685 heme pocket [chemical binding]; other site 264198005686 PAS domain S-box; Region: sensory_box; TIGR00229 264198005687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198005688 dimer interface [polypeptide binding]; other site 264198005689 phosphorylation site [posttranslational modification] 264198005690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005691 ATP binding site [chemical binding]; other site 264198005692 Mg2+ binding site [ion binding]; other site 264198005693 G-X-G motif; other site 264198005694 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 264198005695 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 264198005696 dimer interface [polypeptide binding]; other site 264198005697 TPP-binding site [chemical binding]; other site 264198005698 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264198005699 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 264198005700 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198005701 E3 interaction surface; other site 264198005702 lipoyl attachment site [posttranslational modification]; other site 264198005703 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198005704 E3 interaction surface; other site 264198005705 lipoyl attachment site [posttranslational modification]; other site 264198005706 e3 binding domain; Region: E3_binding; pfam02817 264198005707 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264198005708 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 264198005709 active site 264198005710 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198005711 E3 interaction surface; other site 264198005712 lipoyl attachment site [posttranslational modification]; other site 264198005713 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 264198005714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198005715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198005716 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198005717 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198005718 FAD binding domain; Region: FAD_binding_4; pfam01565 264198005719 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198005720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198005721 DNA-binding site [nucleotide binding]; DNA binding site 264198005722 FCD domain; Region: FCD; pfam07729 264198005723 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198005724 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198005725 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198005726 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198005727 Cysteine-rich domain; Region: CCG; pfam02754 264198005728 Cysteine-rich domain; Region: CCG; pfam02754 264198005729 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 264198005730 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264198005731 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198005732 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 264198005733 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 264198005734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198005735 Walker A/P-loop; other site 264198005736 ATP binding site [chemical binding]; other site 264198005737 Q-loop/lid; other site 264198005738 ABC transporter signature motif; other site 264198005739 Walker B; other site 264198005740 D-loop; other site 264198005741 H-loop/switch region; other site 264198005742 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198005743 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 264198005744 TM-ABC transporter signature motif; other site 264198005745 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 264198005746 zinc binding site [ion binding]; other site 264198005747 putative ligand binding site [chemical binding]; other site 264198005748 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198005749 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198005750 active site 264198005751 catalytic tetrad [active] 264198005752 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 264198005753 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 264198005754 quinone interaction residues [chemical binding]; other site 264198005755 active site 264198005756 catalytic residues [active] 264198005757 FMN binding site [chemical binding]; other site 264198005758 substrate binding site [chemical binding]; other site 264198005759 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 264198005760 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 264198005761 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 264198005762 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 264198005763 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 264198005764 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 264198005765 nudix motif; other site 264198005766 RES domain; Region: RES; smart00953 264198005767 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 264198005768 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 264198005769 4Fe-4S binding domain; Region: Fer4; pfam00037 264198005770 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 264198005771 dimerization interface [polypeptide binding]; other site 264198005772 FAD binding pocket [chemical binding]; other site 264198005773 FAD binding motif [chemical binding]; other site 264198005774 catalytic residues [active] 264198005775 NAD binding pocket [chemical binding]; other site 264198005776 phosphate binding motif [ion binding]; other site 264198005777 beta-alpha-beta structure motif; other site 264198005778 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 264198005779 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 264198005780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198005781 substrate binding site [chemical binding]; other site 264198005782 oxyanion hole (OAH) forming residues; other site 264198005783 trimer interface [polypeptide binding]; other site 264198005784 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 264198005785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198005786 non-specific DNA binding site [nucleotide binding]; other site 264198005787 salt bridge; other site 264198005788 sequence-specific DNA binding site [nucleotide binding]; other site 264198005789 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264198005790 ADP binding site [chemical binding]; other site 264198005791 magnesium binding site [ion binding]; other site 264198005792 putative shikimate binding site; other site 264198005793 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198005794 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 264198005795 acyl-activating enzyme (AAE) consensus motif; other site 264198005796 AMP binding site [chemical binding]; other site 264198005797 active site 264198005798 CoA binding site [chemical binding]; other site 264198005799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005800 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198005801 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 264198005802 putative ligand binding site [chemical binding]; other site 264198005803 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198005804 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198005805 TM-ABC transporter signature motif; other site 264198005806 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198005807 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198005808 TM-ABC transporter signature motif; other site 264198005809 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198005810 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198005811 Walker A/P-loop; other site 264198005812 ATP binding site [chemical binding]; other site 264198005813 Q-loop/lid; other site 264198005814 ABC transporter signature motif; other site 264198005815 Walker B; other site 264198005816 D-loop; other site 264198005817 H-loop/switch region; other site 264198005818 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198005819 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198005820 Walker A/P-loop; other site 264198005821 ATP binding site [chemical binding]; other site 264198005822 Q-loop/lid; other site 264198005823 ABC transporter signature motif; other site 264198005824 Walker B; other site 264198005825 D-loop; other site 264198005826 H-loop/switch region; other site 264198005827 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 264198005828 potassium uptake protein; Region: kup; TIGR00794 264198005829 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 264198005830 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264198005831 NAD binding site [chemical binding]; other site 264198005832 substrate binding site [chemical binding]; other site 264198005833 active site 264198005834 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198005835 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 264198005836 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264198005837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005838 active site 264198005839 phosphorylation site [posttranslational modification] 264198005840 intermolecular recognition site; other site 264198005841 dimerization interface [polypeptide binding]; other site 264198005842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198005843 DNA binding site [nucleotide binding] 264198005844 sensor protein QseC; Provisional; Region: PRK10337 264198005845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198005846 dimer interface [polypeptide binding]; other site 264198005847 phosphorylation site [posttranslational modification] 264198005848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005849 ATP binding site [chemical binding]; other site 264198005850 G-X-G motif; other site 264198005851 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264198005852 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264198005853 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 264198005854 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264198005855 RNA binding site [nucleotide binding]; other site 264198005856 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264198005857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264198005858 DEAD_2; Region: DEAD_2; pfam06733 264198005859 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 264198005860 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 264198005861 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264198005862 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198005863 RNA binding surface [nucleotide binding]; other site 264198005864 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264198005865 active site 264198005866 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 264198005867 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 264198005868 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 264198005869 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 264198005870 putative acyltransferase; Provisional; Region: PRK05790 264198005871 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198005872 dimer interface [polypeptide binding]; other site 264198005873 active site 264198005874 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 264198005875 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198005876 NAD(P) binding site [chemical binding]; other site 264198005877 homotetramer interface [polypeptide binding]; other site 264198005878 homodimer interface [polypeptide binding]; other site 264198005879 active site 264198005880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 264198005881 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 264198005882 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 264198005883 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 264198005884 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264198005885 FMN binding site [chemical binding]; other site 264198005886 active site 264198005887 catalytic residues [active] 264198005888 substrate binding site [chemical binding]; other site 264198005889 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 264198005890 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264198005891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198005892 FeS/SAM binding site; other site 264198005893 TRAM domain; Region: TRAM; cl01282 264198005894 beta-ketothiolase; Provisional; Region: PRK09051 264198005895 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198005896 dimer interface [polypeptide binding]; other site 264198005897 active site 264198005898 cystathionine beta-lyase; Provisional; Region: PRK07050 264198005899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198005900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198005901 catalytic residue [active] 264198005902 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 264198005903 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 264198005904 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264198005905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198005906 motif II; other site 264198005907 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 264198005908 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198005909 metal binding site [ion binding]; metal-binding site 264198005910 putative dimer interface [polypeptide binding]; other site 264198005911 acetylornithine deacetylase; Provisional; Region: PRK07522 264198005912 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 264198005913 metal binding site [ion binding]; metal-binding site 264198005914 putative dimer interface [polypeptide binding]; other site 264198005915 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264198005916 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 264198005917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198005918 ATP binding site [chemical binding]; other site 264198005919 putative Mg++ binding site [ion binding]; other site 264198005920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198005921 nucleotide binding region [chemical binding]; other site 264198005922 ATP-binding site [chemical binding]; other site 264198005923 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 264198005924 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264198005925 substrate binding site; other site 264198005926 dimer interface; other site 264198005927 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 264198005928 homotrimer interaction site [polypeptide binding]; other site 264198005929 zinc binding site [ion binding]; other site 264198005930 CDP-binding sites; other site 264198005931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198005932 Coenzyme A binding pocket [chemical binding]; other site 264198005933 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 264198005934 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264198005935 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264198005936 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 264198005937 dimer interface [polypeptide binding]; other site 264198005938 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264198005939 catalytic triad [active] 264198005940 peroxidatic and resolving cysteines [active] 264198005941 citrate-proton symporter; Provisional; Region: PRK15075 264198005942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005943 putative substrate translocation pore; other site 264198005944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198005945 dimerization interface [polypeptide binding]; other site 264198005946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005947 ATP binding site [chemical binding]; other site 264198005948 Mg2+ binding site [ion binding]; other site 264198005949 G-X-G motif; other site 264198005950 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198005951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005952 active site 264198005953 phosphorylation site [posttranslational modification] 264198005954 intermolecular recognition site; other site 264198005955 dimerization interface [polypeptide binding]; other site 264198005956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198005957 DNA binding site [nucleotide binding] 264198005958 allantoate amidohydrolase; Reviewed; Region: PRK12893 264198005959 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 264198005960 active site 264198005961 metal binding site [ion binding]; metal-binding site 264198005962 dimer interface [polypeptide binding]; other site 264198005963 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264198005964 active site lid residues [active] 264198005965 substrate binding pocket [chemical binding]; other site 264198005966 catalytic residues [active] 264198005967 substrate-Mg2+ binding site; other site 264198005968 aspartate-rich region 1; other site 264198005969 aspartate-rich region 2; other site 264198005970 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198005971 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198005972 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198005973 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198005974 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 264198005975 VanZ like family; Region: VanZ; cl01971 264198005976 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 264198005977 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 264198005978 Uncharacterized conserved protein [Function unknown]; Region: COG4121 264198005979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198005980 trigger factor; Provisional; Region: tig; PRK01490 264198005981 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264198005982 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264198005983 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 264198005984 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264198005985 oligomer interface [polypeptide binding]; other site 264198005986 active site residues [active] 264198005987 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264198005988 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 264198005989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198005990 Walker A motif; other site 264198005991 ATP binding site [chemical binding]; other site 264198005992 Walker B motif; other site 264198005993 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264198005994 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264198005995 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264198005996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198005997 Walker A motif; other site 264198005998 ATP binding site [chemical binding]; other site 264198005999 Walker B motif; other site 264198006000 arginine finger; other site 264198006001 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264198006002 SurA N-terminal domain; Region: SurA_N_3; cl07813 264198006003 periplasmic folding chaperone; Provisional; Region: PRK10788 264198006004 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264198006005 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 264198006006 active site 264198006007 catalytic triad [active] 264198006008 oxyanion hole [active] 264198006009 switch loop; other site 264198006010 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 264198006011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264198006012 Walker A/P-loop; other site 264198006013 ATP binding site [chemical binding]; other site 264198006014 Q-loop/lid; other site 264198006015 ABC transporter signature motif; other site 264198006016 Walker B; other site 264198006017 D-loop; other site 264198006018 H-loop/switch region; other site 264198006019 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 264198006020 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264198006021 active site 264198006022 dimer interface [polypeptide binding]; other site 264198006023 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264198006024 dimer interface [polypeptide binding]; other site 264198006025 active site 264198006026 Uncharacterized conserved protein [Function unknown]; Region: COG0062 264198006027 putative carbohydrate kinase; Provisional; Region: PRK10565 264198006028 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264198006029 putative substrate binding site [chemical binding]; other site 264198006030 putative ATP binding site [chemical binding]; other site 264198006031 amidase; Provisional; Region: PRK07056 264198006032 Amidase; Region: Amidase; cl11426 264198006033 MarR family; Region: MarR_2; cl17246 264198006034 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 264198006035 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264198006036 dimerization interface [polypeptide binding]; other site 264198006037 ATP binding site [chemical binding]; other site 264198006038 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264198006039 dimerization interface [polypeptide binding]; other site 264198006040 ATP binding site [chemical binding]; other site 264198006041 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 264198006042 putative active site [active] 264198006043 catalytic triad [active] 264198006044 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 264198006045 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264198006046 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 264198006047 intracellular septation protein A; Reviewed; Region: PRK00259 264198006048 methionine sulfoxide reductase B; Provisional; Region: PRK00222 264198006049 SelR domain; Region: SelR; pfam01641 264198006050 Uncharacterized conserved protein [Function unknown]; Region: COG0397 264198006051 hypothetical protein; Validated; Region: PRK00029 264198006052 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 264198006053 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 264198006054 dimer interface [polypeptide binding]; other site 264198006055 acyl-activating enzyme (AAE) consensus motif; other site 264198006056 putative active site [active] 264198006057 AMP binding site [chemical binding]; other site 264198006058 putative CoA binding site [chemical binding]; other site 264198006059 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198006060 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198006061 putative ligand binding site [chemical binding]; other site 264198006062 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198006063 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198006064 TM-ABC transporter signature motif; other site 264198006065 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198006066 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198006067 TM-ABC transporter signature motif; other site 264198006068 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198006069 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198006070 Walker A/P-loop; other site 264198006071 ATP binding site [chemical binding]; other site 264198006072 Q-loop/lid; other site 264198006073 ABC transporter signature motif; other site 264198006074 Walker B; other site 264198006075 D-loop; other site 264198006076 H-loop/switch region; other site 264198006077 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198006078 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198006079 Walker A/P-loop; other site 264198006080 ATP binding site [chemical binding]; other site 264198006081 Q-loop/lid; other site 264198006082 ABC transporter signature motif; other site 264198006083 Walker B; other site 264198006084 D-loop; other site 264198006085 H-loop/switch region; other site 264198006086 lysine transporter; Provisional; Region: PRK10836 264198006087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006088 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 264198006089 substrate binding site [chemical binding]; other site 264198006090 oxyanion hole (OAH) forming residues; other site 264198006091 trimer interface [polypeptide binding]; other site 264198006092 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198006093 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198006094 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198006095 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 264198006096 Isochorismatase family; Region: Isochorismatase; pfam00857 264198006097 catalytic triad [active] 264198006098 metal binding site [ion binding]; metal-binding site 264198006099 conserved cis-peptide bond; other site 264198006100 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 264198006101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006102 dimer interface [polypeptide binding]; other site 264198006103 active site 264198006104 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198006105 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198006106 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 264198006107 FAD binding site [chemical binding]; other site 264198006108 substrate binding site [chemical binding]; other site 264198006109 catalytic residues [active] 264198006110 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198006111 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198006112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006113 NAD(P) binding site [chemical binding]; other site 264198006114 active site 264198006115 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198006116 CoenzymeA binding site [chemical binding]; other site 264198006117 subunit interaction site [polypeptide binding]; other site 264198006118 PHB binding site; other site 264198006119 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198006120 Beta-lactamase; Region: Beta-lactamase; pfam00144 264198006121 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 264198006122 Prostaglandin dehydrogenases; Region: PGDH; cd05288 264198006123 NAD(P) binding site [chemical binding]; other site 264198006124 substrate binding site [chemical binding]; other site 264198006125 dimer interface [polypeptide binding]; other site 264198006126 hypothetical protein; Provisional; Region: PRK06208 264198006127 intersubunit interface [polypeptide binding]; other site 264198006128 active site 264198006129 Zn2+ binding site [ion binding]; other site 264198006130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006131 short chain dehydrogenase; Provisional; Region: PRK06181 264198006132 NAD(P) binding site [chemical binding]; other site 264198006133 active site 264198006134 hypothetical protein; Provisional; Region: PRK06194 264198006135 classical (c) SDRs; Region: SDR_c; cd05233 264198006136 NAD(P) binding site [chemical binding]; other site 264198006137 active site 264198006138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198006139 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 264198006140 putative ADP-ribose binding site [chemical binding]; other site 264198006141 putative active site [active] 264198006142 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198006143 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 264198006144 putative active site [active] 264198006145 metal binding site [ion binding]; metal-binding site 264198006146 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264198006147 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198006148 substrate binding pocket [chemical binding]; other site 264198006149 Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401 264198006150 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198006151 active site 264198006152 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 264198006153 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198006154 putative NAD(P) binding site [chemical binding]; other site 264198006155 active site 264198006156 putative substrate binding site [chemical binding]; other site 264198006157 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 264198006158 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198006159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006160 putative substrate translocation pore; other site 264198006161 putative aldolase; Validated; Region: PRK08130 264198006162 intersubunit interface [polypeptide binding]; other site 264198006163 active site 264198006164 Zn2+ binding site [ion binding]; other site 264198006165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 264198006166 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198006167 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198006168 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198006169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198006170 DNA-binding site [nucleotide binding]; DNA binding site 264198006171 FCD domain; Region: FCD; cl11656 264198006172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264198006173 Uncharacterized conserved protein [Function unknown]; Region: COG3332 264198006174 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 264198006175 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 264198006176 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198006177 YceG-like family; Region: YceG; pfam02618 264198006178 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264198006179 dimerization interface [polypeptide binding]; other site 264198006180 thymidylate kinase; Validated; Region: tmk; PRK00698 264198006181 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264198006182 TMP-binding site; other site 264198006183 ATP-binding site [chemical binding]; other site 264198006184 DNA polymerase III subunit delta'; Validated; Region: PRK06964 264198006185 DNA polymerase III subunit delta'; Validated; Region: PRK08485 264198006186 PilZ domain; Region: PilZ; cl01260 264198006187 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264198006188 active site 264198006189 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198006190 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264198006191 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198006192 Uncharacterized conserved protein [Function unknown]; Region: COG3339 264198006193 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 264198006194 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264198006195 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198006196 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198006197 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198006198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006199 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 264198006200 putative effector binding pocket; other site 264198006201 putative dimerization interface [polypeptide binding]; other site 264198006202 DoxX; Region: DoxX; pfam07681 264198006203 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 264198006204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264198006205 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264198006206 Cupin domain; Region: Cupin_2; pfam07883 264198006207 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198006208 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198006209 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198006210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 264198006211 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198006212 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 264198006213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198006216 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 264198006217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198006218 ABC-ATPase subunit interface; other site 264198006219 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 264198006220 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198006221 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198006222 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198006223 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198006224 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 264198006225 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 264198006226 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 264198006227 putative dimer interface [polypeptide binding]; other site 264198006228 N-terminal domain interface [polypeptide binding]; other site 264198006229 putative substrate binding pocket (H-site) [chemical binding]; other site 264198006230 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264198006231 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 264198006232 putative acyl-acceptor binding pocket; other site 264198006233 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198006234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006235 Walker A motif; other site 264198006236 ATP binding site [chemical binding]; other site 264198006237 Walker B motif; other site 264198006238 arginine finger; other site 264198006239 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198006240 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198006241 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 264198006242 NAD(P) binding site [chemical binding]; other site 264198006243 catalytic residues [active] 264198006244 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 264198006245 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198006246 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 264198006247 Trp docking motif [polypeptide binding]; other site 264198006248 cytochrome domain interface [polypeptide binding]; other site 264198006249 active site 264198006250 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198006251 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 264198006252 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198006253 active site 264198006254 catalytic residues [active] 264198006255 metal binding site [ion binding]; metal-binding site 264198006256 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264198006257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198006258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198006259 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198006260 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198006261 carboxyltransferase (CT) interaction site; other site 264198006262 biotinylation site [posttranslational modification]; other site 264198006263 enoyl-CoA hydratase; Provisional; Region: PRK05995 264198006264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006265 substrate binding site [chemical binding]; other site 264198006266 oxyanion hole (OAH) forming residues; other site 264198006267 trimer interface [polypeptide binding]; other site 264198006268 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264198006269 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264198006270 isovaleryl-CoA dehydrogenase; Region: PLN02519 264198006271 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 264198006272 substrate binding site [chemical binding]; other site 264198006273 FAD binding site [chemical binding]; other site 264198006274 catalytic base [active] 264198006275 AMP-binding domain protein; Validated; Region: PRK08315 264198006276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198006277 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 264198006278 acyl-activating enzyme (AAE) consensus motif; other site 264198006279 putative AMP binding site [chemical binding]; other site 264198006280 putative active site [active] 264198006281 putative CoA binding site [chemical binding]; other site 264198006282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198006283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198006284 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198006285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198006286 dimer interface [polypeptide binding]; other site 264198006287 conserved gate region; other site 264198006288 putative PBP binding loops; other site 264198006289 ABC-ATPase subunit interface; other site 264198006290 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 264198006291 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198006292 Walker A/P-loop; other site 264198006293 ATP binding site [chemical binding]; other site 264198006294 Q-loop/lid; other site 264198006295 ABC transporter signature motif; other site 264198006296 Walker B; other site 264198006297 D-loop; other site 264198006298 H-loop/switch region; other site 264198006299 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 264198006300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198006301 substrate binding pocket [chemical binding]; other site 264198006302 membrane-bound complex binding site; other site 264198006303 hinge residues; other site 264198006304 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198006305 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198006306 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198006307 hydrophobic ligand binding site; other site 264198006308 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198006309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198006310 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 264198006311 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198006312 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198006313 NADP binding site [chemical binding]; other site 264198006314 dimer interface [polypeptide binding]; other site 264198006315 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 264198006316 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198006317 NAD(P) binding site [chemical binding]; other site 264198006318 catalytic residues [active] 264198006319 transcriptional regulator; Provisional; Region: PRK10632 264198006320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006321 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198006322 putative effector binding pocket; other site 264198006323 dimerization interface [polypeptide binding]; other site 264198006324 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198006325 [2Fe-2S] cluster binding site [ion binding]; other site 264198006326 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198006327 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198006328 FMN binding site [chemical binding]; other site 264198006329 substrate binding site [chemical binding]; other site 264198006330 putative catalytic residue [active] 264198006331 YciI-like protein; Reviewed; Region: PRK12863 264198006332 glutathione reductase; Validated; Region: PRK06116 264198006333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198006334 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198006335 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 264198006336 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264198006337 C-terminal domain interface [polypeptide binding]; other site 264198006338 GSH binding site (G-site) [chemical binding]; other site 264198006339 dimer interface [polypeptide binding]; other site 264198006340 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 264198006341 N-terminal domain interface [polypeptide binding]; other site 264198006342 putative dimer interface [polypeptide binding]; other site 264198006343 active site 264198006344 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198006345 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 264198006346 putative C-terminal domain interface [polypeptide binding]; other site 264198006347 putative GSH binding site (G-site) [chemical binding]; other site 264198006348 putative dimer interface [polypeptide binding]; other site 264198006349 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 264198006350 putative N-terminal domain interface [polypeptide binding]; other site 264198006351 putative dimer interface [polypeptide binding]; other site 264198006352 putative substrate binding pocket (H-site) [chemical binding]; other site 264198006353 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198006354 FOG: CBS domain [General function prediction only]; Region: COG0517 264198006355 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 264198006356 Cupin domain; Region: Cupin_2; pfam07883 264198006357 ProQ/FINO family; Region: ProQ; pfam04352 264198006358 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 264198006359 Cupin domain; Region: Cupin_2; cl17218 264198006360 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 264198006361 Coenzyme A transferase; Region: CoA_trans; smart00882 264198006362 Coenzyme A transferase; Region: CoA_trans; cl17247 264198006363 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198006364 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198006365 active site 264198006366 nucleophile elbow; other site 264198006367 thiamine pyrophosphate protein; Validated; Region: PRK08199 264198006368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198006369 PYR/PP interface [polypeptide binding]; other site 264198006370 dimer interface [polypeptide binding]; other site 264198006371 TPP binding site [chemical binding]; other site 264198006372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198006373 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 264198006374 TPP-binding site [chemical binding]; other site 264198006375 putative dehydrogenase; Provisional; Region: PRK10098 264198006376 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 264198006377 tartronate semialdehyde reductase; Provisional; Region: PRK15059 264198006378 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198006379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006381 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198006382 putative dimerization interface [polypeptide binding]; other site 264198006383 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 264198006384 Methylmuconolactone methyl-isomerase; Region: MmlI; pfam09448 264198006385 benzoate transport; Region: 2A0115; TIGR00895 264198006386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006387 putative substrate translocation pore; other site 264198006388 Coenzyme A transferase; Region: CoA_trans; cl17247 264198006389 Coenzyme A transferase; Region: CoA_trans; cl17247 264198006390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006392 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198006393 putative dimerization interface [polypeptide binding]; other site 264198006394 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198006395 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264198006396 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198006397 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 264198006398 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 264198006399 short chain dehydrogenase; Provisional; Region: PRK07856 264198006400 classical (c) SDRs; Region: SDR_c; cd05233 264198006401 NAD(P) binding site [chemical binding]; other site 264198006402 active site 264198006403 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 264198006404 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 264198006405 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 264198006406 dimer interface [polypeptide binding]; other site 264198006407 active site/substrate binding site [active] 264198006408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198006409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006410 tropinone reductase; Provisional; Region: PRK09242 264198006411 NAD(P) binding site [chemical binding]; other site 264198006412 active site 264198006413 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 264198006414 putative hydrophobic ligand binding site [chemical binding]; other site 264198006415 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198006416 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 264198006417 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 264198006418 Chromate transporter; Region: Chromate_transp; pfam02417 264198006419 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 264198006420 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198006421 EamA-like transporter family; Region: EamA; pfam00892 264198006422 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 264198006423 ArsC family; Region: ArsC; pfam03960 264198006424 catalytic residues [active] 264198006425 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 264198006426 Sodium Bile acid symporter family; Region: SBF; cl17470 264198006427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198006428 putative DNA binding site [nucleotide binding]; other site 264198006429 putative Zn2+ binding site [ion binding]; other site 264198006430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006432 DNA binding residues [nucleotide binding] 264198006433 dimerization interface [polypeptide binding]; other site 264198006434 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 264198006435 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 264198006436 CysD dimerization site [polypeptide binding]; other site 264198006437 G1 box; other site 264198006438 putative GEF interaction site [polypeptide binding]; other site 264198006439 GTP/Mg2+ binding site [chemical binding]; other site 264198006440 Switch I region; other site 264198006441 G2 box; other site 264198006442 G3 box; other site 264198006443 Switch II region; other site 264198006444 G4 box; other site 264198006445 G5 box; other site 264198006446 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 264198006447 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 264198006448 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 264198006449 ligand-binding site [chemical binding]; other site 264198006450 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 264198006451 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264198006452 Active Sites [active] 264198006453 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 264198006454 short chain dehydrogenase; Provisional; Region: PRK07890 264198006455 classical (c) SDRs; Region: SDR_c; cd05233 264198006456 NAD(P) binding site [chemical binding]; other site 264198006457 active site 264198006458 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 264198006459 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264198006460 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 264198006461 dimerization interface [polypeptide binding]; other site 264198006462 active site 264198006463 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198006464 hypothetical protein; Provisional; Region: PRK06194 264198006465 classical (c) SDRs; Region: SDR_c; cd05233 264198006466 NAD(P) binding site [chemical binding]; other site 264198006467 active site 264198006468 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006470 DNA binding residues [nucleotide binding] 264198006471 dimerization interface [polypeptide binding]; other site 264198006472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198006473 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264198006474 active site 264198006475 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 264198006476 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 264198006477 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 264198006478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006479 Flavin binding site [chemical binding]; other site 264198006480 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 264198006481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198006482 L-aspartate oxidase; Provisional; Region: PRK06175 264198006483 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 264198006484 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264198006485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006486 short chain dehydrogenase; Validated; Region: PRK07069 264198006487 NAD(P) binding site [chemical binding]; other site 264198006488 active site 264198006489 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 264198006490 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 264198006491 FAD binding pocket [chemical binding]; other site 264198006492 FAD binding motif [chemical binding]; other site 264198006493 phosphate binding motif [ion binding]; other site 264198006494 beta-alpha-beta structure motif; other site 264198006495 NAD(p) ribose binding residues [chemical binding]; other site 264198006496 NAD binding pocket [chemical binding]; other site 264198006497 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 264198006498 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198006499 catalytic loop [active] 264198006500 iron binding site [ion binding]; other site 264198006501 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 264198006502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198006503 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 264198006504 acyl-activating enzyme (AAE) consensus motif; other site 264198006505 putative AMP binding site [chemical binding]; other site 264198006506 putative active site [active] 264198006507 putative CoA binding site [chemical binding]; other site 264198006508 SnoaL-like domain; Region: SnoaL_4; pfam13577 264198006509 short chain dehydrogenase; Provisional; Region: PRK08303 264198006510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006511 NAD(P) binding site [chemical binding]; other site 264198006512 active site 264198006513 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 264198006514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006515 classical (c) SDRs; Region: SDR_c; cd05233 264198006516 NAD(P) binding site [chemical binding]; other site 264198006517 active site 264198006518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006519 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198006520 NAD(P) binding site [chemical binding]; other site 264198006521 active site 264198006522 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198006523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006524 NAD(P) binding site [chemical binding]; other site 264198006525 active site 264198006526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006527 classical (c) SDRs; Region: SDR_c; cd05233 264198006528 NAD(P) binding site [chemical binding]; other site 264198006529 active site 264198006530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006532 DNA binding residues [nucleotide binding] 264198006533 dimerization interface [polypeptide binding]; other site 264198006534 EthD domain; Region: EthD; cl17553 264198006535 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 264198006536 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 264198006537 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 264198006538 active site 264198006539 Fe binding site [ion binding]; other site 264198006540 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 264198006541 Coenzyme A transferase; Region: CoA_trans; cl17247 264198006542 enoyl-CoA hydratase; Provisional; Region: PRK08290 264198006543 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006544 substrate binding site [chemical binding]; other site 264198006545 oxyanion hole (OAH) forming residues; other site 264198006546 trimer interface [polypeptide binding]; other site 264198006547 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 264198006548 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198006549 FMN binding site [chemical binding]; other site 264198006550 substrate binding site [chemical binding]; other site 264198006551 putative catalytic residue [active] 264198006552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006553 enoyl-CoA hydratase; Provisional; Region: PRK06495 264198006554 substrate binding site [chemical binding]; other site 264198006555 oxyanion hole (OAH) forming residues; other site 264198006556 trimer interface [polypeptide binding]; other site 264198006557 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006558 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198006559 FAD binding site [chemical binding]; other site 264198006560 substrate binding site [chemical binding]; other site 264198006561 catalytic base [active] 264198006562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198006564 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 264198006565 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006566 dimer interface [polypeptide binding]; other site 264198006567 active site 264198006568 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198006569 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264198006570 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264198006571 short chain dehydrogenase; Provisional; Region: PRK07791 264198006572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006573 NAD(P) binding site [chemical binding]; other site 264198006574 active site 264198006575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006576 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198006577 active site 264198006578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198006580 active site 264198006581 short chain dehydrogenase; Provisional; Region: PRK07831 264198006582 classical (c) SDRs; Region: SDR_c; cd05233 264198006583 NAD(P) binding site [chemical binding]; other site 264198006584 active site 264198006585 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198006586 putative active site [active] 264198006587 putative catalytic site [active] 264198006588 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 264198006589 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006590 dimer interface [polypeptide binding]; other site 264198006591 active site 264198006592 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198006593 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198006594 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198006595 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264198006596 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 264198006597 active site 264198006598 FMN binding site [chemical binding]; other site 264198006599 substrate binding site [chemical binding]; other site 264198006600 putative catalytic residue [active] 264198006601 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198006602 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 264198006603 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006604 classical (c) SDRs; Region: SDR_c; cd05233 264198006605 NAD(P) binding site [chemical binding]; other site 264198006606 active site 264198006607 Cupin domain; Region: Cupin_2; pfam07883 264198006608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006609 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264198006610 NAD(P) binding site [chemical binding]; other site 264198006611 active site 264198006612 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198006613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198006614 DNA-binding site [nucleotide binding]; DNA binding site 264198006615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198006616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198006617 homodimer interface [polypeptide binding]; other site 264198006618 catalytic residue [active] 264198006619 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 264198006620 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264198006621 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264198006622 active site 264198006623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006625 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 264198006626 substrate binding pocket [chemical binding]; other site 264198006627 dimerization interface [polypeptide binding]; other site 264198006628 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 264198006629 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 264198006630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198006631 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 264198006632 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 264198006633 putative FMN binding site [chemical binding]; other site 264198006634 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 264198006635 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198006636 dimer interface [polypeptide binding]; other site 264198006637 active site 264198006638 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 264198006639 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198006640 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198006641 active site 264198006642 dimer interface [polypeptide binding]; other site 264198006643 metal binding site [ion binding]; metal-binding site 264198006644 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 264198006645 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 264198006646 putative active site [active] 264198006647 putative metal binding site [ion binding]; other site 264198006648 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198006649 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264198006650 Walker A/P-loop; other site 264198006651 ATP binding site [chemical binding]; other site 264198006652 Q-loop/lid; other site 264198006653 ABC transporter signature motif; other site 264198006654 Walker B; other site 264198006655 D-loop; other site 264198006656 H-loop/switch region; other site 264198006657 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198006658 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 264198006659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198006660 putative PBP binding loops; other site 264198006661 dimer interface [polypeptide binding]; other site 264198006662 ABC-ATPase subunit interface; other site 264198006663 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198006664 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198006665 substrate binding pocket [chemical binding]; other site 264198006666 membrane-bound complex binding site; other site 264198006667 hinge residues; other site 264198006668 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198006669 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198006670 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198006671 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198006672 NADP binding site [chemical binding]; other site 264198006673 dimer interface [polypeptide binding]; other site 264198006674 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198006675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006676 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198006677 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198006678 eyelet of channel; other site 264198006679 trimer interface [polypeptide binding]; other site 264198006680 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264198006681 classical (c) SDRs; Region: SDR_c; cd05233 264198006682 NAD(P) binding site [chemical binding]; other site 264198006683 active site 264198006684 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198006685 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198006686 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198006687 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 264198006688 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198006689 NAD(P) binding site [chemical binding]; other site 264198006690 Serine hydrolase; Region: Ser_hydrolase; pfam06821 264198006691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198006692 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 264198006693 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264198006694 catalytic residues [active] 264198006695 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198006696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198006697 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198006698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198006701 dimerization interface [polypeptide binding]; other site 264198006702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198006703 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 264198006704 catalytic site [active] 264198006705 Malonate transporter MadL subunit; Region: MadL; cl04273 264198006706 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 264198006707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198006708 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198006709 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198006710 conserved cys residue [active] 264198006711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198006712 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 264198006713 active site 264198006714 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198006715 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198006716 conserved cys residue [active] 264198006717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198006718 benzoate transport; Region: 2A0115; TIGR00895 264198006719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006720 putative substrate translocation pore; other site 264198006721 amidase; Provisional; Region: PRK07487 264198006722 Amidase; Region: Amidase; cl11426 264198006723 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198006724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006725 putative substrate translocation pore; other site 264198006726 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198006727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198006728 active site 264198006729 metal binding site [ion binding]; metal-binding site 264198006730 short chain dehydrogenase; Provisional; Region: PRK12937 264198006731 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 264198006732 NADP binding site [chemical binding]; other site 264198006733 homodimer interface [polypeptide binding]; other site 264198006734 active site 264198006735 substrate binding site [chemical binding]; other site 264198006736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006738 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 264198006739 putative effector binding pocket; other site 264198006740 putative dimerization interface [polypeptide binding]; other site 264198006741 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 264198006742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198006743 catalytic residue [active] 264198006744 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 264198006745 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 264198006746 Int/Topo IB signature motif; other site 264198006747 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198006748 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 264198006749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198006750 salt bridge; other site 264198006751 non-specific DNA binding site [nucleotide binding]; other site 264198006752 sequence-specific DNA binding site [nucleotide binding]; other site 264198006753 HipA N-terminal domain; Region: Couple_hipA; pfam13657 264198006754 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 264198006755 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264198006756 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264198006757 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198006758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006760 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198006761 putative dimerization interface [polypeptide binding]; other site 264198006762 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198006763 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 264198006764 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 264198006765 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 264198006766 dimer interface [polypeptide binding]; other site 264198006767 active site 264198006768 heme binding site [chemical binding]; other site 264198006769 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 264198006770 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 264198006771 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198006772 AAA ATPase domain; Region: AAA_16; pfam13191 264198006773 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198006774 FAD binding domain; Region: FAD_binding_4; pfam01565 264198006775 Berberine and berberine like; Region: BBE; pfam08031 264198006776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198006777 PAS domain; Region: PAS_9; pfam13426 264198006778 putative active site [active] 264198006779 heme pocket [chemical binding]; other site 264198006780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198006781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198006782 metal binding site [ion binding]; metal-binding site 264198006783 active site 264198006784 I-site; other site 264198006785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198006786 Hemerythrin-like domain; Region: Hr-like; cd12108 264198006787 Fe binding site [ion binding]; other site 264198006788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198006791 putative dimerization interface [polypeptide binding]; other site 264198006792 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 264198006793 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 264198006794 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 264198006795 von Willebrand factor type A domain; Region: VWA_2; pfam13519 264198006796 metal ion-dependent adhesion site (MIDAS); other site 264198006797 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 264198006798 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 264198006799 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198006800 putative substrate binding site [chemical binding]; other site 264198006801 putative ATP binding site [chemical binding]; other site 264198006802 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 264198006803 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264198006804 active site 264198006805 dimer interface [polypeptide binding]; other site 264198006806 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264198006807 dimer interface [polypeptide binding]; other site 264198006808 active site 264198006809 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264198006810 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264198006811 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264198006812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264198006813 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 264198006814 putative ligand binding site [chemical binding]; other site 264198006815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198006816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264198006817 TM-ABC transporter signature motif; other site 264198006818 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264198006819 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264198006820 Walker A/P-loop; other site 264198006821 ATP binding site [chemical binding]; other site 264198006822 Q-loop/lid; other site 264198006823 ABC transporter signature motif; other site 264198006824 Walker B; other site 264198006825 D-loop; other site 264198006826 H-loop/switch region; other site 264198006827 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264198006828 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264198006829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264198006830 nucleotide binding site [chemical binding]; other site 264198006831 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198006832 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198006833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264198006834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006836 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 264198006837 putative dimerization interface [polypeptide binding]; other site 264198006838 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198006839 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264198006840 Amidase; Region: Amidase; cl11426 264198006841 hypothetical protein; Validated; Region: PRK07121 264198006842 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 264198006843 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 264198006844 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198006845 putative NAD(P) binding site [chemical binding]; other site 264198006846 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 264198006847 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264198006848 phosphate binding site [ion binding]; other site 264198006849 carbon starvation induced protein; Validated; Region: PRK02963 264198006850 substrate binding pocket [chemical binding]; other site 264198006851 active site 264198006852 iron coordination sites [ion binding]; other site 264198006853 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198006854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006855 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198006856 dimerization interface [polypeptide binding]; other site 264198006857 substrate binding pocket [chemical binding]; other site 264198006858 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198006859 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198006860 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198006861 active site 264198006862 iron coordination sites [ion binding]; other site 264198006863 substrate binding pocket [chemical binding]; other site 264198006864 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198006865 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198006866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198006867 enoyl-CoA hydratase; Provisional; Region: PRK08252 264198006868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006869 substrate binding site [chemical binding]; other site 264198006870 oxyanion hole (OAH) forming residues; other site 264198006871 trimer interface [polypeptide binding]; other site 264198006872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006873 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 264198006874 NAD(P) binding site [chemical binding]; other site 264198006875 active site 264198006876 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 264198006877 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006878 dimer interface [polypeptide binding]; other site 264198006879 active site 264198006880 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198006881 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198006882 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198006883 enoyl-CoA hydratase; Provisional; Region: PRK09245 264198006884 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006885 substrate binding site [chemical binding]; other site 264198006886 oxyanion hole (OAH) forming residues; other site 264198006887 trimer interface [polypeptide binding]; other site 264198006888 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 264198006889 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198006890 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006891 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198006892 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198006893 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 264198006894 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 264198006895 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 264198006896 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198006897 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 264198006898 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264198006899 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 264198006900 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 264198006901 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 264198006902 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 264198006903 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264198006904 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 264198006905 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 264198006906 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 264198006907 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 264198006908 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198006909 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198006910 dimer interface [polypeptide binding]; other site 264198006911 putative CheW interface [polypeptide binding]; other site 264198006912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264198006913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198006914 Coenzyme A binding pocket [chemical binding]; other site 264198006915 2-isopropylmalate synthase; Validated; Region: PRK03739 264198006916 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 264198006917 active site 264198006918 catalytic residues [active] 264198006919 metal binding site [ion binding]; metal-binding site 264198006920 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 264198006921 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198006922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198006923 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 264198006924 dimerizarion interface [polypeptide binding]; other site 264198006925 CrgA pocket; other site 264198006926 substrate binding pocket [chemical binding]; other site 264198006927 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198006928 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198006929 octamer interface [polypeptide binding]; other site 264198006930 active site 264198006931 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 264198006932 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198006933 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264198006934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198006936 active site 264198006937 phosphorylation site [posttranslational modification] 264198006938 intermolecular recognition site; other site 264198006939 dimerization interface [polypeptide binding]; other site 264198006940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006941 DNA binding residues [nucleotide binding] 264198006942 dimerization interface [polypeptide binding]; other site 264198006943 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 264198006944 putative chaperone protein EcpD; Provisional; Region: PRK09926 264198006945 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264198006946 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264198006947 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 264198006948 PapC N-terminal domain; Region: PapC_N; pfam13954 264198006949 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264198006950 PapC C-terminal domain; Region: PapC_C; pfam13953 264198006951 Fimbrial protein; Region: Fimbrial; pfam00419 264198006952 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264198006953 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 264198006954 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198006955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006956 Walker A motif; other site 264198006957 ATP binding site [chemical binding]; other site 264198006958 Walker B motif; other site 264198006959 arginine finger; other site 264198006960 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198006961 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 264198006962 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 264198006963 dimerization interface [polypeptide binding]; other site 264198006964 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 264198006965 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 264198006966 dimerization interface [polypeptide binding]; other site 264198006967 putative path to active site cavity [active] 264198006968 diiron center [ion binding]; other site 264198006969 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 264198006970 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198006971 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198006972 catalytic loop [active] 264198006973 iron binding site [ion binding]; other site 264198006974 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 264198006975 FAD binding pocket [chemical binding]; other site 264198006976 FAD binding motif [chemical binding]; other site 264198006977 phosphate binding motif [ion binding]; other site 264198006978 beta-alpha-beta structure motif; other site 264198006979 NAD binding pocket [chemical binding]; other site 264198006980 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 264198006981 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 264198006982 dimer interface [polypeptide binding]; other site 264198006983 active site 264198006984 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198006985 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 264198006986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006987 putative substrate translocation pore; other site 264198006988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198006989 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 264198006990 homotrimer interaction site [polypeptide binding]; other site 264198006991 putative active site [active] 264198006992 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 264198006993 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198006994 putative active site [active] 264198006995 catalytic site [active] 264198006996 Helix-turn-helix domain; Region: HTH_28; pfam13518 264198006997 Winged helix-turn helix; Region: HTH_29; pfam13551 264198006998 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 264198006999 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 264198007000 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 264198007001 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 264198007002 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 264198007003 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 264198007004 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198007005 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264198007006 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198007007 aspartate racemase; Region: asp_race; TIGR00035 264198007008 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 264198007009 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198007010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198007011 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198007012 substrate binding pocket [chemical binding]; other site 264198007013 membrane-bound complex binding site; other site 264198007014 hinge residues; other site 264198007015 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 264198007016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264198007017 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 264198007018 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264198007019 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264198007020 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 264198007021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007022 Walker A motif; other site 264198007023 ATP binding site [chemical binding]; other site 264198007024 Walker B motif; other site 264198007025 arginine finger; other site 264198007026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007027 Walker A motif; other site 264198007028 ATP binding site [chemical binding]; other site 264198007029 Walker B motif; other site 264198007030 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264198007031 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 264198007032 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 264198007033 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 264198007034 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 264198007035 Protein of unknown function (DUF796); Region: DUF796; pfam05638 264198007036 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 264198007037 Protein of unknown function (DUF877); Region: DUF877; pfam05943 264198007038 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 264198007039 Response regulator receiver domain; Region: Response_reg; pfam00072 264198007040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007041 active site 264198007042 phosphorylation site [posttranslational modification] 264198007043 intermolecular recognition site; other site 264198007044 dimerization interface [polypeptide binding]; other site 264198007045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198007046 DNA binding residues [nucleotide binding] 264198007047 dimerization interface [polypeptide binding]; other site 264198007048 HDOD domain; Region: HDOD; pfam08668 264198007049 PAS domain; Region: PAS_9; pfam13426 264198007050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198007051 putative active site [active] 264198007052 heme pocket [chemical binding]; other site 264198007053 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198007054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198007055 metal binding site [ion binding]; metal-binding site 264198007056 active site 264198007057 I-site; other site 264198007058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198007059 Ion channel; Region: Ion_trans_2; pfam07885 264198007060 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 264198007061 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 264198007062 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198007063 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198007064 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198007065 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 264198007066 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 264198007067 dimer interface [polypeptide binding]; other site 264198007068 active site 264198007069 heme binding site [chemical binding]; other site 264198007070 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 264198007071 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198007072 dinuclear metal binding motif [ion binding]; other site 264198007073 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198007074 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198007075 catalytic loop [active] 264198007076 iron binding site [ion binding]; other site 264198007077 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198007078 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198007079 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198007080 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198007081 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198007082 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 264198007083 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198007084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198007085 PAS fold; Region: PAS_3; pfam08447 264198007086 putative active site [active] 264198007087 heme pocket [chemical binding]; other site 264198007088 PAS fold; Region: PAS_3; pfam08447 264198007089 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198007090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198007091 metal binding site [ion binding]; metal-binding site 264198007092 active site 264198007093 I-site; other site 264198007094 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264198007095 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264198007096 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198007097 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264198007098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198007099 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198007100 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198007101 DNA binding residues [nucleotide binding] 264198007102 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 264198007103 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 264198007104 nucleotide binding site [chemical binding]; other site 264198007105 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264198007106 SBD interface [polypeptide binding]; other site 264198007107 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 264198007108 nucleotide binding site [chemical binding]; other site 264198007109 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264198007110 SBD interface [polypeptide binding]; other site 264198007111 DNA-K related protein; Region: DUF3731; pfam12531 264198007112 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198007113 EamA-like transporter family; Region: EamA; pfam00892 264198007114 EamA-like transporter family; Region: EamA; pfam00892 264198007115 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 264198007116 FOG: CBS domain [General function prediction only]; Region: COG0517 264198007117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 264198007118 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 264198007119 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 264198007120 putative active site [active] 264198007121 putative dimer interface [polypeptide binding]; other site 264198007122 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 264198007123 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 264198007124 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 264198007125 peptidase domain interface [polypeptide binding]; other site 264198007126 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 264198007127 active site 264198007128 catalytic triad [active] 264198007129 calcium binding site [ion binding]; other site 264198007130 Helix-turn-helix domain; Region: HTH_17; pfam12728 264198007131 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 264198007132 dimer interface [polypeptide binding]; other site 264198007133 active site 264198007134 coenzyme A binding site [chemical binding]; other site 264198007135 citrylCoA binding site [chemical binding]; other site 264198007136 Citrate synthase; Region: Citrate_synt; pfam00285 264198007137 oxalacetate/citrate binding site [chemical binding]; other site 264198007138 catalytic triad [active] 264198007139 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198007140 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 264198007141 putative ligand binding site [chemical binding]; other site 264198007142 NAD binding site [chemical binding]; other site 264198007143 catalytic site [active] 264198007144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198007145 classical (c) SDRs; Region: SDR_c; cd05233 264198007146 NAD(P) binding site [chemical binding]; other site 264198007147 active site 264198007148 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198007149 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198007150 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 264198007151 FAD binding pocket [chemical binding]; other site 264198007152 FAD binding motif [chemical binding]; other site 264198007153 phosphate binding motif [ion binding]; other site 264198007154 beta-alpha-beta structure motif; other site 264198007155 NAD binding pocket [chemical binding]; other site 264198007156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007157 putative substrate translocation pore; other site 264198007158 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 264198007159 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264198007160 active site 264198007161 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 264198007162 Part of AAA domain; Region: AAA_19; pfam13245 264198007163 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 264198007164 AAA domain; Region: AAA_12; pfam13087 264198007165 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 264198007166 Transglycosylase; Region: Transgly; pfam00912 264198007167 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264198007168 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264198007169 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 264198007170 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264198007171 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 264198007172 active sites [active] 264198007173 tetramer interface [polypeptide binding]; other site 264198007174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198007175 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198007176 substrate binding pocket [chemical binding]; other site 264198007177 membrane-bound complex binding site; other site 264198007178 hinge residues; other site 264198007179 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198007180 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198007181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007182 Walker A motif; other site 264198007183 ATP binding site [chemical binding]; other site 264198007184 Walker B motif; other site 264198007185 arginine finger; other site 264198007186 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198007187 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 264198007188 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 264198007189 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 264198007190 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 264198007191 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 264198007192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198007193 FeS/SAM binding site; other site 264198007194 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 264198007195 Cytochrome c; Region: Cytochrom_C; cl11414 264198007196 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198007197 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 264198007198 dimer interface [polypeptide binding]; other site 264198007199 Trp docking motif [polypeptide binding]; other site 264198007200 active site 264198007201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198007202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007203 active site 264198007204 phosphorylation site [posttranslational modification] 264198007205 intermolecular recognition site; other site 264198007206 dimerization interface [polypeptide binding]; other site 264198007207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198007208 DNA binding residues [nucleotide binding] 264198007209 dimerization interface [polypeptide binding]; other site 264198007210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264198007211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198007212 Histidine kinase; Region: HisKA_3; pfam07730 264198007213 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 264198007214 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264198007215 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198007216 N-terminal plug; other site 264198007217 ligand-binding site [chemical binding]; other site 264198007218 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198007219 RNA polymerase sigma factor; Provisional; Region: PRK12533 264198007220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198007221 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 264198007222 DNA binding residues [nucleotide binding] 264198007223 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 264198007224 Aspartase; Region: Aspartase; cd01357 264198007225 active sites [active] 264198007226 tetramer interface [polypeptide binding]; other site 264198007227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198007228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198007229 Putative cyclase; Region: Cyclase; pfam04199 264198007230 fumarylacetoacetase; Region: PLN02856 264198007231 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 264198007232 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198007233 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198007234 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198007235 eyelet of channel; other site 264198007236 trimer interface [polypeptide binding]; other site 264198007237 Predicted acyl esterases [General function prediction only]; Region: COG2936 264198007238 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 264198007239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198007240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007241 Surface antigen; Region: Bac_surface_Ag; pfam01103 264198007242 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 264198007243 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264198007244 ATP-grasp domain; Region: ATP-grasp; pfam02222 264198007245 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264198007246 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198007247 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 264198007248 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 264198007249 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198007250 Zn2+ binding site [ion binding]; other site 264198007251 Mg2+ binding site [ion binding]; other site 264198007252 Uncharacterized conserved protein [Function unknown]; Region: COG1359 264198007253 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198007254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198007255 dimer interface [polypeptide binding]; other site 264198007256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007257 catalytic residue [active] 264198007258 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198007259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198007260 DNA-binding site [nucleotide binding]; DNA binding site 264198007261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198007262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007263 homodimer interface [polypeptide binding]; other site 264198007264 catalytic residue [active] 264198007265 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264198007266 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264198007267 Propionate catabolism activator; Region: PrpR_N; pfam06506 264198007268 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 264198007269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198007270 putative active site [active] 264198007271 heme pocket [chemical binding]; other site 264198007272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007273 Walker A motif; other site 264198007274 ATP binding site [chemical binding]; other site 264198007275 Walker B motif; other site 264198007276 arginine finger; other site 264198007277 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198007278 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 264198007279 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198007280 tetramer interface [polypeptide binding]; other site 264198007281 active site 264198007282 Mg2+/Mn2+ binding site [ion binding]; other site 264198007283 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198007284 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 264198007285 dimer interface [polypeptide binding]; other site 264198007286 active site 264198007287 citrylCoA binding site [chemical binding]; other site 264198007288 oxalacetate/citrate binding site [chemical binding]; other site 264198007289 coenzyme A binding site [chemical binding]; other site 264198007290 catalytic triad [active] 264198007291 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 264198007292 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264198007293 substrate binding site [chemical binding]; other site 264198007294 ligand binding site [chemical binding]; other site 264198007295 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 264198007296 substrate binding site [chemical binding]; other site 264198007297 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 264198007298 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 264198007299 active site 264198007300 homodimer interface [polypeptide binding]; other site 264198007301 homotetramer interface [polypeptide binding]; other site 264198007302 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264198007303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198007304 dimer interface [polypeptide binding]; other site 264198007305 phosphorylation site [posttranslational modification] 264198007306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198007307 ATP binding site [chemical binding]; other site 264198007308 Mg2+ binding site [ion binding]; other site 264198007309 G-X-G motif; other site 264198007310 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264198007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007312 active site 264198007313 phosphorylation site [posttranslational modification] 264198007314 intermolecular recognition site; other site 264198007315 dimerization interface [polypeptide binding]; other site 264198007316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198007317 DNA binding site [nucleotide binding] 264198007318 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198007319 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198007320 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198007321 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198007322 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198007323 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198007324 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198007325 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198007326 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 264198007327 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198007328 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198007329 acyl-activating enzyme (AAE) consensus motif; other site 264198007330 AMP binding site [chemical binding]; other site 264198007331 active site 264198007332 CoA binding site [chemical binding]; other site 264198007333 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198007334 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198007335 substrate binding site [chemical binding]; other site 264198007336 oxyanion hole (OAH) forming residues; other site 264198007337 trimer interface [polypeptide binding]; other site 264198007338 benzoate transport; Region: 2A0115; TIGR00895 264198007339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007340 putative substrate translocation pore; other site 264198007341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007342 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 264198007343 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 264198007344 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198007345 putative NAD(P) binding site [chemical binding]; other site 264198007346 catalytic Zn binding site [ion binding]; other site 264198007347 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 264198007348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007349 NAD binding site [chemical binding]; other site 264198007350 catalytic residues [active] 264198007351 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198007352 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198007353 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198007354 classical (c) SDRs; Region: SDR_c; cd05233 264198007355 NAD(P) binding site [chemical binding]; other site 264198007356 active site 264198007357 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198007358 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198007359 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198007360 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198007361 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198007362 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198007363 thiolase; Provisional; Region: PRK06158 264198007364 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198007365 active site 264198007366 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 264198007367 homodimer interaction site [polypeptide binding]; other site 264198007368 putative active site [active] 264198007369 putative catalytic site [active] 264198007370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198007371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198007372 active site 264198007373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198007375 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007376 dimerization interface [polypeptide binding]; other site 264198007377 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198007378 CoenzymeA binding site [chemical binding]; other site 264198007379 subunit interaction site [polypeptide binding]; other site 264198007380 PHB binding site; other site 264198007381 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 264198007382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 264198007383 MOSC domain; Region: MOSC; pfam03473 264198007384 3-alpha domain; Region: 3-alpha; pfam03475 264198007385 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 264198007386 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 264198007387 catalytic triad [active] 264198007388 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 264198007389 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264198007390 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 264198007391 active site 264198007392 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198007393 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007394 NAD binding site [chemical binding]; other site 264198007395 catalytic residues [active] 264198007396 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 264198007397 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198007398 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198007399 ABC transporter; Region: ABC_tran_2; pfam12848 264198007400 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198007401 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264198007402 dimer interface [polypeptide binding]; other site 264198007403 catalytic triad [active] 264198007404 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264198007405 nucleoside/Zn binding site; other site 264198007406 dimer interface [polypeptide binding]; other site 264198007407 catalytic motif [active] 264198007408 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 264198007409 active site 264198007410 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 264198007411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198007412 FeS/SAM binding site; other site 264198007413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198007414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007415 putative substrate translocation pore; other site 264198007416 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 264198007417 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 264198007418 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198007419 putative active site [active] 264198007420 putative metal binding site [ion binding]; other site 264198007421 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 264198007422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198007423 ATP binding site [chemical binding]; other site 264198007424 putative Mg++ binding site [ion binding]; other site 264198007425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198007426 nucleotide binding region [chemical binding]; other site 264198007427 ATP-binding site [chemical binding]; other site 264198007428 DEAD/H associated; Region: DEAD_assoc; pfam08494 264198007429 GMP synthase; Reviewed; Region: guaA; PRK00074 264198007430 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264198007431 AMP/PPi binding site [chemical binding]; other site 264198007432 candidate oxyanion hole; other site 264198007433 catalytic triad [active] 264198007434 potential glutamine specificity residues [chemical binding]; other site 264198007435 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264198007436 ATP Binding subdomain [chemical binding]; other site 264198007437 Ligand Binding sites [chemical binding]; other site 264198007438 Dimerization subdomain; other site 264198007439 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264198007440 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264198007441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 264198007442 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 264198007443 active site 264198007444 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198007445 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 264198007446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 264198007447 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 264198007448 putative coenzyme Q binding site [chemical binding]; other site 264198007449 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264198007450 SmpB-tmRNA interface; other site 264198007451 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264198007452 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264198007453 phosphoenolpyruvate synthase; Validated; Region: PRK06464 264198007454 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264198007455 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264198007456 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264198007457 PEP synthetase regulatory protein; Provisional; Region: PRK05339 264198007458 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264198007459 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264198007460 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264198007461 RNA/DNA hybrid binding site [nucleotide binding]; other site 264198007462 active site 264198007463 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 264198007464 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 264198007465 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264198007466 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 264198007467 active site 264198007468 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264198007469 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 264198007470 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 264198007471 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 264198007472 trimer interface [polypeptide binding]; other site 264198007473 active site 264198007474 UDP-GlcNAc binding site [chemical binding]; other site 264198007475 lipid binding site [chemical binding]; lipid-binding site 264198007476 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 264198007477 periplasmic chaperone; Provisional; Region: PRK10780 264198007478 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264198007479 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264198007480 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264198007481 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264198007482 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264198007483 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264198007484 Surface antigen; Region: Bac_surface_Ag; pfam01103 264198007485 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264198007486 zinc metallopeptidase RseP; Provisional; Region: PRK10779 264198007487 active site 264198007488 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264198007489 protein binding site [polypeptide binding]; other site 264198007490 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 264198007491 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 264198007492 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 264198007493 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 264198007494 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 264198007495 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 264198007496 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264198007497 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 264198007498 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 264198007499 catalytic residue [active] 264198007500 putative FPP diphosphate binding site; other site 264198007501 putative FPP binding hydrophobic cleft; other site 264198007502 dimer interface [polypeptide binding]; other site 264198007503 putative IPP diphosphate binding site; other site 264198007504 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264198007505 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 264198007506 hinge region; other site 264198007507 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264198007508 putative nucleotide binding site [chemical binding]; other site 264198007509 uridine monophosphate binding site [chemical binding]; other site 264198007510 homohexameric interface [polypeptide binding]; other site 264198007511 elongation factor Ts; Provisional; Region: tsf; PRK09377 264198007512 UBA/TS-N domain; Region: UBA; pfam00627 264198007513 Elongation factor TS; Region: EF_TS; pfam00889 264198007514 Elongation factor TS; Region: EF_TS; pfam00889 264198007515 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264198007516 rRNA interaction site [nucleotide binding]; other site 264198007517 S8 interaction site; other site 264198007518 putative laminin-1 binding site; other site 264198007519 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264198007520 active site 264198007521 PII uridylyl-transferase; Provisional; Region: PRK03059 264198007522 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264198007523 metal binding triad; other site 264198007524 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264198007525 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198007526 Zn2+ binding site [ion binding]; other site 264198007527 Mg2+ binding site [ion binding]; other site 264198007528 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 264198007529 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 264198007530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198007531 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264198007532 RNA binding surface [nucleotide binding]; other site 264198007533 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264198007534 active site 264198007535 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264198007536 active site 264198007537 catalytic residues [active] 264198007538 metal binding site [ion binding]; metal-binding site 264198007539 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264198007540 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264198007541 nucleotide binding pocket [chemical binding]; other site 264198007542 K-X-D-G motif; other site 264198007543 catalytic site [active] 264198007544 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264198007545 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264198007546 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264198007547 Dimer interface [polypeptide binding]; other site 264198007548 BRCT sequence motif; other site 264198007549 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 264198007550 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264198007551 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264198007552 Walker A/P-loop; other site 264198007553 ATP binding site [chemical binding]; other site 264198007554 Q-loop/lid; other site 264198007555 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 264198007556 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264198007557 Q-loop/lid; other site 264198007558 ABC transporter signature motif; other site 264198007559 Walker B; other site 264198007560 D-loop; other site 264198007561 H-loop/switch region; other site 264198007562 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198007563 dinuclear metal binding motif [ion binding]; other site 264198007564 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198007565 EamA-like transporter family; Region: EamA; pfam00892 264198007566 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 264198007567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198007568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007569 homodimer interface [polypeptide binding]; other site 264198007570 catalytic residue [active] 264198007571 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 264198007572 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 264198007573 trimer interface [polypeptide binding]; other site 264198007574 active site 264198007575 substrate binding site [chemical binding]; other site 264198007576 CoA binding site [chemical binding]; other site 264198007577 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 264198007578 ArsC family; Region: ArsC; pfam03960 264198007579 putative catalytic residues [active] 264198007580 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 264198007581 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 264198007582 metal binding site [ion binding]; metal-binding site 264198007583 dimer interface [polypeptide binding]; other site 264198007584 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 264198007585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198007586 S-adenosylmethionine binding site [chemical binding]; other site 264198007587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198007589 putative substrate translocation pore; other site 264198007590 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 264198007591 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198007592 NADP binding site [chemical binding]; other site 264198007593 dimer interface [polypeptide binding]; other site 264198007594 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198007595 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198007596 conserved cys residue [active] 264198007597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198007598 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264198007599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198007600 NAD(P) binding site [chemical binding]; other site 264198007601 active site 264198007602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198007604 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 264198007605 putative effector binding pocket; other site 264198007606 putative dimerization interface [polypeptide binding]; other site 264198007607 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198007608 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007609 NAD binding site [chemical binding]; other site 264198007610 catalytic residues [active] 264198007611 enoyl-CoA hydratase; Provisional; Region: PRK06210 264198007612 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198007613 substrate binding site [chemical binding]; other site 264198007614 oxyanion hole (OAH) forming residues; other site 264198007615 trimer interface [polypeptide binding]; other site 264198007616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198007617 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198007618 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007619 NAD binding site [chemical binding]; other site 264198007620 catalytic residues [active] 264198007621 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198007622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198007623 substrate binding site [chemical binding]; other site 264198007624 oxyanion hole (OAH) forming residues; other site 264198007625 trimer interface [polypeptide binding]; other site 264198007626 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 264198007627 CoA binding domain; Region: CoA_binding_2; pfam13380 264198007628 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198007629 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198007630 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198007631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198007633 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198007634 putative dimerization interface [polypeptide binding]; other site 264198007635 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 264198007636 RibD C-terminal domain; Region: RibD_C; cl17279 264198007637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198007638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198007639 non-specific DNA binding site [nucleotide binding]; other site 264198007640 salt bridge; other site 264198007641 sequence-specific DNA binding site [nucleotide binding]; other site 264198007642 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198007643 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198007644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198007645 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198007646 acyl-activating enzyme (AAE) consensus motif; other site 264198007647 acyl-activating enzyme (AAE) consensus motif; other site 264198007648 putative AMP binding site [chemical binding]; other site 264198007649 putative active site [active] 264198007650 putative CoA binding site [chemical binding]; other site 264198007651 Isochorismatase family; Region: Isochorismatase; pfam00857 264198007652 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 264198007653 catalytic triad [active] 264198007654 conserved cis-peptide bond; other site 264198007655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198007657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007658 dimerization interface [polypeptide binding]; other site 264198007659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198007660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198007661 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 264198007662 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198007663 NAD(P) binding site [chemical binding]; other site 264198007664 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198007665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198007667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007668 dimerization interface [polypeptide binding]; other site 264198007669 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 264198007670 putative active site [active] 264198007671 Zn binding site [ion binding]; other site 264198007672 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 264198007673 SxDxEG motif; other site 264198007674 active site 264198007675 metal binding site [ion binding]; metal-binding site 264198007676 homopentamer interface [polypeptide binding]; other site 264198007677 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 264198007678 homodimer interface [polypeptide binding]; other site 264198007679 homotetramer interface [polypeptide binding]; other site 264198007680 active site pocket [active] 264198007681 cleavage site 264198007682 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 264198007683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007684 dimer interface [polypeptide binding]; other site 264198007685 conserved gate region; other site 264198007686 putative PBP binding loops; other site 264198007687 ABC-ATPase subunit interface; other site 264198007688 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 264198007689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007690 dimer interface [polypeptide binding]; other site 264198007691 conserved gate region; other site 264198007692 putative PBP binding loops; other site 264198007693 ABC-ATPase subunit interface; other site 264198007694 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 264198007695 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 264198007696 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 264198007697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198007698 Walker A/P-loop; other site 264198007699 ATP binding site [chemical binding]; other site 264198007700 Q-loop/lid; other site 264198007701 ABC transporter signature motif; other site 264198007702 Walker B; other site 264198007703 D-loop; other site 264198007704 H-loop/switch region; other site 264198007705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264198007706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198007707 Walker A/P-loop; other site 264198007708 ATP binding site [chemical binding]; other site 264198007709 Q-loop/lid; other site 264198007710 ABC transporter signature motif; other site 264198007711 Walker B; other site 264198007712 D-loop; other site 264198007713 H-loop/switch region; other site 264198007714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198007715 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 264198007716 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 264198007717 catalytic nucleophile [active] 264198007718 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198007719 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198007720 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198007721 putative active site [active] 264198007722 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 264198007723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198007724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198007725 ABC transporter; Region: ABC_tran_2; pfam12848 264198007726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198007727 disulfide bond formation protein B; Provisional; Region: PRK02110 264198007728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264198007729 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264198007730 DNA repair protein RadA; Provisional; Region: PRK11823 264198007731 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264198007732 Walker A motif/ATP binding site; other site 264198007733 ATP binding site [chemical binding]; other site 264198007734 Walker B motif; other site 264198007735 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264198007736 alanine racemase; Reviewed; Region: dadX; PRK03646 264198007737 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 264198007738 active site 264198007739 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198007740 substrate binding site [chemical binding]; other site 264198007741 catalytic residues [active] 264198007742 dimer interface [polypeptide binding]; other site 264198007743 lysophospholipid transporter LplT; Provisional; Region: PRK11195 264198007744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007745 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 264198007746 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 264198007747 Fe-S cluster binding site [ion binding]; other site 264198007748 active site 264198007749 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 264198007750 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264198007751 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264198007752 Glycoprotease family; Region: Peptidase_M22; pfam00814 264198007753 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 264198007754 acyl-CoA binding pocket [chemical binding]; other site 264198007755 CoA binding site [chemical binding]; other site 264198007756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007757 putative transporter; Provisional; Region: PRK10504 264198007758 putative substrate translocation pore; other site 264198007759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007760 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 264198007761 putative hydrophobic ligand binding site [chemical binding]; other site 264198007762 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 264198007763 active site 264198007764 catalytic triad [active] 264198007765 oxyanion hole [active] 264198007766 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264198007767 active site 264198007768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198007769 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 264198007770 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 264198007771 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198007772 putative acyl-acceptor binding pocket; other site 264198007773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198007774 CoenzymeA binding site [chemical binding]; other site 264198007775 subunit interaction site [polypeptide binding]; other site 264198007776 PHB binding site; other site 264198007777 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 264198007778 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264198007779 catalytic residues [active] 264198007780 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 264198007781 malate synthase A; Region: malate_syn_A; TIGR01344 264198007782 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 264198007783 active site 264198007784 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264198007785 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 264198007786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198007787 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198007788 putative effector binding pocket; other site 264198007789 dimerization interface [polypeptide binding]; other site 264198007790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198007791 Ligand Binding Site [chemical binding]; other site 264198007792 Response regulator receiver domain; Region: Response_reg; pfam00072 264198007793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007794 active site 264198007795 phosphorylation site [posttranslational modification] 264198007796 intermolecular recognition site; other site 264198007797 dimerization interface [polypeptide binding]; other site 264198007798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198007799 putative CheW interface [polypeptide binding]; other site 264198007800 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198007801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198007802 dimerization interface [polypeptide binding]; other site 264198007803 PAS fold; Region: PAS; pfam00989 264198007804 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264198007805 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198007806 putative binding surface; other site 264198007807 active site 264198007808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198007809 ATP binding site [chemical binding]; other site 264198007810 Mg2+ binding site [ion binding]; other site 264198007811 G-X-G motif; other site 264198007812 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 264198007813 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 264198007814 isocitrate lyase; Provisional; Region: PRK15063 264198007815 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198007816 tetramer interface [polypeptide binding]; other site 264198007817 active site 264198007818 Mg2+/Mn2+ binding site [ion binding]; other site 264198007819 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264198007820 putative active site pocket [active] 264198007821 dimerization interface [polypeptide binding]; other site 264198007822 putative catalytic residue [active] 264198007823 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 264198007824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198007826 putative substrate translocation pore; other site 264198007827 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264198007828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007829 active site 264198007830 phosphorylation site [posttranslational modification] 264198007831 intermolecular recognition site; other site 264198007832 dimerization interface [polypeptide binding]; other site 264198007833 LytTr DNA-binding domain; Region: LytTR; smart00850 264198007834 Histidine kinase; Region: His_kinase; pfam06580 264198007835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198007836 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 264198007837 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 264198007838 substrate binding site [chemical binding]; other site 264198007839 dimerization interface [polypeptide binding]; other site 264198007840 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 264198007841 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 264198007842 Walker A/P-loop; other site 264198007843 ATP binding site [chemical binding]; other site 264198007844 Q-loop/lid; other site 264198007845 ABC transporter signature motif; other site 264198007846 Walker B; other site 264198007847 D-loop; other site 264198007848 H-loop/switch region; other site 264198007849 TOBE-like domain; Region: TOBE_3; pfam12857 264198007850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007851 dimer interface [polypeptide binding]; other site 264198007852 conserved gate region; other site 264198007853 putative PBP binding loops; other site 264198007854 ABC-ATPase subunit interface; other site 264198007855 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264198007856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007857 dimer interface [polypeptide binding]; other site 264198007858 conserved gate region; other site 264198007859 putative PBP binding loops; other site 264198007860 ABC-ATPase subunit interface; other site 264198007861 Serine hydrolase; Region: Ser_hydrolase; pfam06821 264198007862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198007863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 264198007864 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 264198007865 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 264198007866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198007867 Walker A/P-loop; other site 264198007868 ATP binding site [chemical binding]; other site 264198007869 Q-loop/lid; other site 264198007870 ABC transporter signature motif; other site 264198007871 Walker B; other site 264198007872 D-loop; other site 264198007873 H-loop/switch region; other site 264198007874 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198007875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007876 dimer interface [polypeptide binding]; other site 264198007877 conserved gate region; other site 264198007878 putative PBP binding loops; other site 264198007879 ABC-ATPase subunit interface; other site 264198007880 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 264198007881 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264198007882 active site 264198007883 dimer interface [polypeptide binding]; other site 264198007884 non-prolyl cis peptide bond; other site 264198007885 insertion regions; other site 264198007886 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198007887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198007888 substrate binding pocket [chemical binding]; other site 264198007889 membrane-bound complex binding site; other site 264198007890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198007891 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198007892 substrate binding pocket [chemical binding]; other site 264198007893 membrane-bound complex binding site; other site 264198007894 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198007895 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198007896 Autotransporter beta-domain; Region: Autotransporter; smart00869 264198007897 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264198007898 Clp amino terminal domain; Region: Clp_N; pfam02861 264198007899 Clp amino terminal domain; Region: Clp_N; pfam02861 264198007900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007901 Walker A motif; other site 264198007902 ATP binding site [chemical binding]; other site 264198007903 Walker B motif; other site 264198007904 arginine finger; other site 264198007905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007906 Walker A motif; other site 264198007907 ATP binding site [chemical binding]; other site 264198007908 Walker B motif; other site 264198007909 arginine finger; other site 264198007910 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264198007911 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 264198007912 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198007913 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198007914 TM-ABC transporter signature motif; other site 264198007915 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198007916 TM-ABC transporter signature motif; other site 264198007917 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198007918 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198007919 Walker A/P-loop; other site 264198007920 ATP binding site [chemical binding]; other site 264198007921 Q-loop/lid; other site 264198007922 ABC transporter signature motif; other site 264198007923 Walker B; other site 264198007924 D-loop; other site 264198007925 H-loop/switch region; other site 264198007926 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198007927 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198007928 Walker A/P-loop; other site 264198007929 ATP binding site [chemical binding]; other site 264198007930 Q-loop/lid; other site 264198007931 ABC transporter signature motif; other site 264198007932 Walker B; other site 264198007933 D-loop; other site 264198007934 H-loop/switch region; other site 264198007935 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198007936 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 264198007937 putative ligand binding site [chemical binding]; other site 264198007938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198007939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198007940 chromosome condensation membrane protein; Provisional; Region: PRK14196 264198007941 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 264198007942 MoaE homodimer interface [polypeptide binding]; other site 264198007943 MoaD interaction [polypeptide binding]; other site 264198007944 active site residues [active] 264198007945 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 264198007946 MoaE interaction surface [polypeptide binding]; other site 264198007947 MoeB interaction surface [polypeptide binding]; other site 264198007948 thiocarboxylated glycine; other site 264198007949 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264198007950 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264198007951 dimer interface [polypeptide binding]; other site 264198007952 putative functional site; other site 264198007953 putative MPT binding site; other site 264198007954 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 264198007955 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 264198007956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007957 catalytic residue [active] 264198007958 homoserine dehydrogenase; Provisional; Region: PRK06349 264198007959 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 264198007960 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 264198007961 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 264198007962 aminotransferase AlaT; Validated; Region: PRK09265 264198007963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198007964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007965 homodimer interface [polypeptide binding]; other site 264198007966 catalytic residue [active] 264198007967 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 264198007968 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 264198007969 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198007970 catalytic triad [active] 264198007971 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 264198007972 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 264198007973 putative active site [active] 264198007974 PhoH-like protein; Region: PhoH; pfam02562 264198007975 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264198007976 NlpC/P60 family; Region: NLPC_P60; pfam00877 264198007977 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264198007978 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 264198007979 replicative DNA helicase; Provisional; Region: PRK07004 264198007980 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264198007981 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264198007982 Walker A motif; other site 264198007983 ATP binding site [chemical binding]; other site 264198007984 Walker B motif; other site 264198007985 DNA binding loops [nucleotide binding] 264198007986 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264198007987 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264198007988 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264198007989 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 264198007990 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 264198007991 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 264198007992 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 264198007993 active site 264198007994 homotetramer interface [polypeptide binding]; other site 264198007995 homodimer interface [polypeptide binding]; other site 264198007996 LexA repressor; Validated; Region: PRK00215 264198007997 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 264198007998 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264198007999 Catalytic site [active] 264198008000 Lysozyme family protein [General function prediction only]; Region: COG5526 264198008001 CHAT domain; Region: CHAT; cl17868 264198008002 SIR2-like domain; Region: SIR2_2; pfam13289 264198008003 AAA ATPase domain; Region: AAA_16; pfam13191 264198008004 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264198008005 FOG: WD40 repeat [General function prediction only]; Region: COG2319 264198008006 structural tetrad; other site 264198008007 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 264198008008 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264198008009 FMN binding site [chemical binding]; other site 264198008010 active site 264198008011 catalytic residues [active] 264198008012 substrate binding site [chemical binding]; other site 264198008013 Predicted flavoprotein [General function prediction only]; Region: COG0431 264198008014 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198008015 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 264198008016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198008017 substrate binding site [chemical binding]; other site 264198008018 oxyanion hole (OAH) forming residues; other site 264198008019 trimer interface [polypeptide binding]; other site 264198008020 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 264198008021 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198008022 Tar ligand binding domain homologue; Region: TarH; pfam02203 264198008023 dimer interface [polypeptide binding]; other site 264198008024 ligand binding site [chemical binding]; other site 264198008025 HAMP domain; Region: HAMP; pfam00672 264198008026 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198008027 dimer interface [polypeptide binding]; other site 264198008028 putative CheW interface [polypeptide binding]; other site 264198008029 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 264198008030 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264198008031 G1 box; other site 264198008032 putative GEF interaction site [polypeptide binding]; other site 264198008033 GTP/Mg2+ binding site [chemical binding]; other site 264198008034 Switch I region; other site 264198008035 G2 box; other site 264198008036 G3 box; other site 264198008037 Switch II region; other site 264198008038 G4 box; other site 264198008039 G5 box; other site 264198008040 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264198008041 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264198008042 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198008043 MarR family; Region: MarR; pfam01047 264198008044 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198008045 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 264198008046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198008047 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198008048 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198008049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198008050 putative substrate translocation pore; other site 264198008051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198008052 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 264198008053 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264198008054 RNA binding site [nucleotide binding]; other site 264198008055 active site 264198008056 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 264198008057 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 264198008058 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 264198008059 translation initiation factor IF-2; Region: IF-2; TIGR00487 264198008060 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264198008061 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264198008062 G1 box; other site 264198008063 putative GEF interaction site [polypeptide binding]; other site 264198008064 GTP/Mg2+ binding site [chemical binding]; other site 264198008065 Switch I region; other site 264198008066 G2 box; other site 264198008067 G3 box; other site 264198008068 Switch II region; other site 264198008069 G4 box; other site 264198008070 G5 box; other site 264198008071 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264198008072 Translation-initiation factor 2; Region: IF-2; pfam11987 264198008073 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264198008074 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 264198008075 NusA N-terminal domain; Region: NusA_N; pfam08529 264198008076 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264198008077 RNA binding site [nucleotide binding]; other site 264198008078 homodimer interface [polypeptide binding]; other site 264198008079 NusA-like KH domain; Region: KH_5; pfam13184 264198008080 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264198008081 G-X-X-G motif; other site 264198008082 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 264198008083 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 264198008084 ribosome maturation protein RimP; Reviewed; Region: PRK00092 264198008085 Sm and related proteins; Region: Sm_like; cl00259 264198008086 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 264198008087 putative oligomer interface [polypeptide binding]; other site 264198008088 putative RNA binding site [nucleotide binding]; other site 264198008089 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264198008090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198008091 RNA binding surface [nucleotide binding]; other site 264198008092 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 264198008093 probable active site [active] 264198008094 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 264198008095 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264198008096 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198008097 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198008098 ligand binding site [chemical binding]; other site 264198008099 flexible hinge region; other site 264198008100 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198008101 putative switch regulator; other site 264198008102 non-specific DNA interactions [nucleotide binding]; other site 264198008103 DNA binding site [nucleotide binding] 264198008104 sequence specific DNA binding site [nucleotide binding]; other site 264198008105 putative cAMP binding site [chemical binding]; other site 264198008106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 264198008107 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 264198008108 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264198008109 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 264198008110 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 264198008111 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198008112 Cytochrome c; Region: Cytochrom_C; pfam00034 264198008113 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 264198008114 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 264198008115 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 264198008116 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 264198008117 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 264198008118 Low-spin heme binding site [chemical binding]; other site 264198008119 Putative water exit pathway; other site 264198008120 Binuclear center (active site) [active] 264198008121 Putative proton exit pathway; other site 264198008122 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 264198008123 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 264198008124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198008125 metal-binding site [ion binding] 264198008126 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 264198008127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198008128 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 264198008129 Predicted ATPase [General function prediction only]; Region: COG1485 264198008130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198008131 Walker B; other site 264198008132 D-loop; other site 264198008133 H-loop/switch region; other site 264198008134 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 264198008135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198008136 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198008137 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 264198008138 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198008139 E3 interaction surface; other site 264198008140 lipoyl attachment site [posttranslational modification]; other site 264198008141 e3 binding domain; Region: E3_binding; pfam02817 264198008142 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264198008143 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264198008144 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264198008145 TPP-binding site [chemical binding]; other site 264198008146 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 264198008147 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 264198008148 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 264198008149 putative active site [active] 264198008150 catalytic site [active] 264198008151 putative metal binding site [ion binding]; other site 264198008152 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264198008153 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 264198008154 Walker A/P-loop; other site 264198008155 ATP binding site [chemical binding]; other site 264198008156 Q-loop/lid; other site 264198008157 ABC transporter signature motif; other site 264198008158 Walker B; other site 264198008159 D-loop; other site 264198008160 H-loop/switch region; other site 264198008161 TOBE domain; Region: TOBE_2; pfam08402 264198008162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264198008163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008164 dimer interface [polypeptide binding]; other site 264198008165 conserved gate region; other site 264198008166 putative PBP binding loops; other site 264198008167 ABC-ATPase subunit interface; other site 264198008168 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 264198008169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008170 dimer interface [polypeptide binding]; other site 264198008171 conserved gate region; other site 264198008172 putative PBP binding loops; other site 264198008173 ABC-ATPase subunit interface; other site 264198008174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264198008175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264198008176 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 264198008177 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264198008178 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 264198008179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198008180 active site 264198008181 phosphorylation site [posttranslational modification] 264198008182 intermolecular recognition site; other site 264198008183 dimerization interface [polypeptide binding]; other site 264198008184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008185 Walker A motif; other site 264198008186 ATP binding site [chemical binding]; other site 264198008187 Walker B motif; other site 264198008188 arginine finger; other site 264198008189 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198008190 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264198008191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198008192 dimer interface [polypeptide binding]; other site 264198008193 phosphorylation site [posttranslational modification] 264198008194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008195 ATP binding site [chemical binding]; other site 264198008196 Mg2+ binding site [ion binding]; other site 264198008197 G-X-G motif; other site 264198008198 glutamine synthetase; Provisional; Region: glnA; PRK09469 264198008199 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264198008200 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264198008201 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 264198008202 active site residue [active] 264198008203 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 264198008204 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 264198008205 putative MPT binding site; other site 264198008206 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 264198008207 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 264198008208 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 264198008209 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264198008210 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 264198008211 NodB motif; other site 264198008212 active site 264198008213 metal binding site [ion binding]; metal-binding site 264198008214 Uncharacterized conserved protein [Function unknown]; Region: COG3391 264198008215 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 264198008216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198008217 ATP binding site [chemical binding]; other site 264198008218 putative Mg++ binding site [ion binding]; other site 264198008219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198008220 nucleotide binding region [chemical binding]; other site 264198008221 ATP-binding site [chemical binding]; other site 264198008222 Helicase associated domain (HA2); Region: HA2; pfam04408 264198008223 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 264198008224 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 264198008225 N-acetylglutamate synthase; Validated; Region: PRK05279 264198008226 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 264198008227 putative feedback inhibition sensing region; other site 264198008228 putative nucleotide binding site [chemical binding]; other site 264198008229 putative substrate binding site [chemical binding]; other site 264198008230 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 264198008231 oxidative damage protection protein; Provisional; Region: PRK05408 264198008232 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 264198008233 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264198008234 active site 264198008235 dimer interface [polypeptide binding]; other site 264198008236 transaldolase-like protein; Provisional; Region: PTZ00411 264198008237 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 264198008238 active site 264198008239 dimer interface [polypeptide binding]; other site 264198008240 catalytic residue [active] 264198008241 NAD-dependent deacetylase; Provisional; Region: PRK00481 264198008242 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 264198008243 NAD+ binding site [chemical binding]; other site 264198008244 substrate binding site [chemical binding]; other site 264198008245 Zn binding site [ion binding]; other site 264198008246 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 264198008247 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 264198008248 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264198008249 ribonuclease R; Region: RNase_R; TIGR02063 264198008250 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 264198008251 RNB domain; Region: RNB; pfam00773 264198008252 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 264198008253 RNA binding site [nucleotide binding]; other site 264198008254 Predicted transcriptional regulator [Transcription]; Region: COG1959 264198008255 Transcriptional regulator; Region: Rrf2; pfam02082 264198008256 Transcriptional regulator; Region: Rrf2; cl17282 264198008257 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 264198008258 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264198008259 NAD binding site [chemical binding]; other site 264198008260 substrate binding site [chemical binding]; other site 264198008261 putative active site [active] 264198008262 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 264198008263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198008264 active site 264198008265 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264198008266 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264198008267 GDP-binding site [chemical binding]; other site 264198008268 ACT binding site; other site 264198008269 IMP binding site; other site 264198008270 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 264198008271 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264198008272 dimer interface [polypeptide binding]; other site 264198008273 motif 1; other site 264198008274 active site 264198008275 motif 2; other site 264198008276 motif 3; other site 264198008277 HflC protein; Region: hflC; TIGR01932 264198008278 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 264198008279 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 264198008280 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 264198008281 HflK protein; Region: hflK; TIGR01933 264198008282 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264198008283 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 264198008284 HflX GTPase family; Region: HflX; cd01878 264198008285 G1 box; other site 264198008286 GTP/Mg2+ binding site [chemical binding]; other site 264198008287 Switch I region; other site 264198008288 G2 box; other site 264198008289 G3 box; other site 264198008290 Switch II region; other site 264198008291 G4 box; other site 264198008292 G5 box; other site 264198008293 bacterial Hfq-like; Region: Hfq; cd01716 264198008294 hexamer interface [polypeptide binding]; other site 264198008295 Sm1 motif; other site 264198008296 RNA binding site [nucleotide binding]; other site 264198008297 Sm2 motif; other site 264198008298 GTP-binding protein Der; Reviewed; Region: PRK00093 264198008299 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264198008300 G1 box; other site 264198008301 GTP/Mg2+ binding site [chemical binding]; other site 264198008302 Switch I region; other site 264198008303 G2 box; other site 264198008304 Switch II region; other site 264198008305 G3 box; other site 264198008306 G4 box; other site 264198008307 G5 box; other site 264198008308 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264198008309 G1 box; other site 264198008310 GTP/Mg2+ binding site [chemical binding]; other site 264198008311 Switch I region; other site 264198008312 G2 box; other site 264198008313 G3 box; other site 264198008314 Switch II region; other site 264198008315 G4 box; other site 264198008316 G5 box; other site 264198008317 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 264198008318 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264198008319 Trp docking motif [polypeptide binding]; other site 264198008320 active site 264198008321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 264198008322 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 264198008323 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 264198008324 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264198008325 dimer interface [polypeptide binding]; other site 264198008326 motif 1; other site 264198008327 active site 264198008328 motif 2; other site 264198008329 motif 3; other site 264198008330 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264198008331 anticodon binding site; other site 264198008332 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 264198008333 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264198008334 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264198008335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198008336 non-specific DNA binding site [nucleotide binding]; other site 264198008337 salt bridge; other site 264198008338 sequence-specific DNA binding site [nucleotide binding]; other site 264198008339 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 264198008340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198008341 binding surface 264198008342 TPR motif; other site 264198008343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198008344 binding surface 264198008345 TPR motif; other site 264198008346 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 264198008347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198008348 FeS/SAM binding site; other site 264198008349 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264198008350 active site 264198008351 multimer interface [polypeptide binding]; other site 264198008352 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 264198008353 YccA-like proteins; Region: YccA_like; cd10433 264198008354 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 264198008355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264198008356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198008357 S-adenosylmethionine binding site [chemical binding]; other site 264198008358 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264198008359 putative catalytic site [active] 264198008360 putative metal binding site [ion binding]; other site 264198008361 putative phosphate binding site [ion binding]; other site 264198008362 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 264198008363 active site 264198008364 catalytic site [active] 264198008365 substrate binding site [chemical binding]; other site 264198008366 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 264198008367 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 264198008368 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198008369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198008370 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198008371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198008372 DNA binding residues [nucleotide binding] 264198008373 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198008374 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198008375 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264198008376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264198008377 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 264198008378 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198008379 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 264198008380 NAD(P) binding site [chemical binding]; other site 264198008381 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198008382 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198008383 trimer interface [polypeptide binding]; other site 264198008384 eyelet of channel; other site 264198008385 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264198008386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198008387 active site 264198008388 phosphorylation site [posttranslational modification] 264198008389 intermolecular recognition site; other site 264198008390 dimerization interface [polypeptide binding]; other site 264198008391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198008392 DNA binding site [nucleotide binding] 264198008393 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198008394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198008395 HAMP domain; Region: HAMP; pfam00672 264198008396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198008397 dimer interface [polypeptide binding]; other site 264198008398 phosphorylation site [posttranslational modification] 264198008399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008400 ATP binding site [chemical binding]; other site 264198008401 Mg2+ binding site [ion binding]; other site 264198008402 G-X-G motif; other site 264198008403 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198008404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008405 dimer interface [polypeptide binding]; other site 264198008406 conserved gate region; other site 264198008407 putative PBP binding loops; other site 264198008408 ABC-ATPase subunit interface; other site 264198008409 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198008410 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198008411 Walker A/P-loop; other site 264198008412 ATP binding site [chemical binding]; other site 264198008413 Q-loop/lid; other site 264198008414 ABC transporter signature motif; other site 264198008415 Walker B; other site 264198008416 D-loop; other site 264198008417 H-loop/switch region; other site 264198008418 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264198008419 NMT1-like family; Region: NMT1_2; pfam13379 264198008420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198008421 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198008422 active site 264198008423 catalytic residues [active] 264198008424 metal binding site [ion binding]; metal-binding site 264198008425 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198008426 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198008427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198008428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198008429 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198008430 putative dimerization interface [polypeptide binding]; other site 264198008431 recombination protein RecR; Reviewed; Region: recR; PRK00076 264198008432 RecR protein; Region: RecR; pfam02132 264198008433 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264198008434 putative active site [active] 264198008435 putative metal-binding site [ion binding]; other site 264198008436 tetramer interface [polypeptide binding]; other site 264198008437 hypothetical protein; Validated; Region: PRK00153 264198008438 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 264198008439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008440 Walker A motif; other site 264198008441 ATP binding site [chemical binding]; other site 264198008442 Walker B motif; other site 264198008443 DNA polymerase III subunit delta'; Validated; Region: PRK08485 264198008444 arginine finger; other site 264198008445 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264198008446 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 264198008447 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 264198008448 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 264198008449 active site 264198008450 dimer interface [polypeptide binding]; other site 264198008451 effector binding site; other site 264198008452 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264198008453 Cys-rich peptide, TIGR04165 family; Region: methano_modCys 264198008454 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 264198008455 Family description; Region: UvrD_C_2; pfam13538 264198008456 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264198008457 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 264198008458 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264198008459 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198008460 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198008461 catalytic residues [active] 264198008462 transcription termination factor Rho; Provisional; Region: rho; PRK09376 264198008463 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 264198008464 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264198008465 RNA binding site [nucleotide binding]; other site 264198008466 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264198008467 multimer interface [polypeptide binding]; other site 264198008468 Walker A motif; other site 264198008469 ATP binding site [chemical binding]; other site 264198008470 Walker B motif; other site 264198008471 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 264198008472 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 264198008473 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198008474 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198008475 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 264198008476 multidrug efflux protein; Reviewed; Region: PRK01766 264198008477 cation binding site [ion binding]; other site 264198008478 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264198008479 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264198008480 active site 264198008481 HIGH motif; other site 264198008482 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264198008483 active site 264198008484 KMSKS motif; other site 264198008485 hypothetical protein; Provisional; Region: PRK10279 264198008486 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 264198008487 nucleophile elbow; other site 264198008488 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264198008489 NlpC/P60 family; Region: NLPC_P60; pfam00877 264198008490 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 264198008491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198008492 Walker A/P-loop; other site 264198008493 ATP binding site [chemical binding]; other site 264198008494 Q-loop/lid; other site 264198008495 ABC transporter signature motif; other site 264198008496 Walker B; other site 264198008497 D-loop; other site 264198008498 H-loop/switch region; other site 264198008499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 264198008500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198008501 Walker A/P-loop; other site 264198008502 ATP binding site [chemical binding]; other site 264198008503 Q-loop/lid; other site 264198008504 ABC transporter signature motif; other site 264198008505 Walker B; other site 264198008506 D-loop; other site 264198008507 H-loop/switch region; other site 264198008508 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 264198008509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008510 dimer interface [polypeptide binding]; other site 264198008511 conserved gate region; other site 264198008512 putative PBP binding loops; other site 264198008513 ABC-ATPase subunit interface; other site 264198008514 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 264198008515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008516 dimer interface [polypeptide binding]; other site 264198008517 conserved gate region; other site 264198008518 putative PBP binding loops; other site 264198008519 ABC-ATPase subunit interface; other site 264198008520 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264198008521 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 264198008522 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 264198008523 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 264198008524 NAD binding site [chemical binding]; other site 264198008525 homotetramer interface [polypeptide binding]; other site 264198008526 homodimer interface [polypeptide binding]; other site 264198008527 substrate binding site [chemical binding]; other site 264198008528 active site 264198008529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198008530 putative substrate translocation pore; other site 264198008531 Serine hydrolase; Region: Ser_hydrolase; pfam06821 264198008532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198008533 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198008534 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198008535 trimer interface [polypeptide binding]; other site 264198008536 eyelet of channel; other site 264198008537 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 264198008538 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 264198008539 TAP-like protein; Region: Abhydrolase_4; pfam08386 264198008540 Phasin protein; Region: Phasin_2; pfam09361 264198008541 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 264198008542 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 264198008543 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198008544 putative active site [active] 264198008545 putative catalytic site [active] 264198008546 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198008547 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198008548 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198008549 active site 264198008550 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198008551 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198008552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198008553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198008554 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198008555 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198008556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198008557 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198008558 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 264198008559 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 264198008560 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264198008561 catalytic residues [active] 264198008562 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198008563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198008564 acyl-activating enzyme (AAE) consensus motif; other site 264198008565 AMP binding site [chemical binding]; other site 264198008566 active site 264198008567 CoA binding site [chemical binding]; other site 264198008568 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198008569 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198008570 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198008571 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198008572 NADP binding site [chemical binding]; other site 264198008573 dimer interface [polypeptide binding]; other site 264198008574 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198008575 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198008576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198008577 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 264198008578 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 264198008579 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198008580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198008581 metal binding site [ion binding]; metal-binding site 264198008582 active site 264198008583 I-site; other site 264198008584 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264198008585 rRNA binding site [nucleotide binding]; other site 264198008586 predicted 30S ribosome binding site; other site 264198008587 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198008588 catalytic core [active] 264198008589 Putative hemolysin [General function prediction only]; Region: COG3176 264198008590 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 264198008591 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 264198008592 polyphosphate kinase; Provisional; Region: PRK05443 264198008593 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 264198008594 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 264198008595 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 264198008596 putative domain interface [polypeptide binding]; other site 264198008597 putative active site [active] 264198008598 catalytic site [active] 264198008599 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 264198008600 putative domain interface [polypeptide binding]; other site 264198008601 putative active site [active] 264198008602 catalytic site [active] 264198008603 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 264198008604 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198008605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198008606 dimer interface [polypeptide binding]; other site 264198008607 phosphorylation site [posttranslational modification] 264198008608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008609 ATP binding site [chemical binding]; other site 264198008610 Mg2+ binding site [ion binding]; other site 264198008611 G-X-G motif; other site 264198008612 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 264198008613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198008614 active site 264198008615 phosphorylation site [posttranslational modification] 264198008616 intermolecular recognition site; other site 264198008617 dimerization interface [polypeptide binding]; other site 264198008618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198008619 DNA binding site [nucleotide binding] 264198008620 transcriptional regulator PhoU; Provisional; Region: PRK11115 264198008621 PhoU domain; Region: PhoU; pfam01895 264198008622 PhoU domain; Region: PhoU; pfam01895 264198008623 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 264198008624 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 264198008625 Walker A/P-loop; other site 264198008626 ATP binding site [chemical binding]; other site 264198008627 Q-loop/lid; other site 264198008628 ABC transporter signature motif; other site 264198008629 Walker B; other site 264198008630 D-loop; other site 264198008631 H-loop/switch region; other site 264198008632 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 264198008633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008634 dimer interface [polypeptide binding]; other site 264198008635 conserved gate region; other site 264198008636 putative PBP binding loops; other site 264198008637 ABC-ATPase subunit interface; other site 264198008638 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 264198008639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008640 dimer interface [polypeptide binding]; other site 264198008641 conserved gate region; other site 264198008642 ABC-ATPase subunit interface; other site 264198008643 PBP superfamily domain; Region: PBP_like_2; cl17296 264198008644 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 264198008645 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264198008646 active site 264198008647 substrate binding site [chemical binding]; other site 264198008648 metal binding site [ion binding]; metal-binding site 264198008649 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264198008650 dihydropteroate synthase; Region: DHPS; TIGR01496 264198008651 substrate binding pocket [chemical binding]; other site 264198008652 dimer interface [polypeptide binding]; other site 264198008653 inhibitor binding site; inhibition site 264198008654 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 264198008655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008656 Walker A motif; other site 264198008657 ATP binding site [chemical binding]; other site 264198008658 Walker B motif; other site 264198008659 arginine finger; other site 264198008660 Peptidase family M41; Region: Peptidase_M41; pfam01434 264198008661 FtsJ-like methyltransferase; Region: FtsJ; cl17430 264198008662 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 264198008663 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 264198008664 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 264198008665 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264198008666 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264198008667 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264198008668 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 264198008669 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198008670 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264198008671 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 264198008672 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198008673 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198008674 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 264198008675 IMP binding site; other site 264198008676 dimer interface [polypeptide binding]; other site 264198008677 interdomain contacts; other site 264198008678 partial ornithine binding site; other site 264198008679 leucine export protein LeuE; Provisional; Region: PRK10958 264198008680 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 264198008681 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 264198008682 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 264198008683 catalytic site [active] 264198008684 subunit interface [polypeptide binding]; other site 264198008685 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198008686 homotrimer interaction site [polypeptide binding]; other site 264198008687 putative active site [active] 264198008688 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198008689 active site 264198008690 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198008691 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198008692 acyl-activating enzyme (AAE) consensus motif; other site 264198008693 AMP binding site [chemical binding]; other site 264198008694 active site 264198008695 CoA binding site [chemical binding]; other site 264198008696 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198008697 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198008698 active site 264198008699 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198008700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198008701 substrate binding site [chemical binding]; other site 264198008702 oxyanion hole (OAH) forming residues; other site 264198008703 trimer interface [polypeptide binding]; other site 264198008704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198008705 classical (c) SDRs; Region: SDR_c; cd05233 264198008706 NAD(P) binding site [chemical binding]; other site 264198008707 active site 264198008708 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 264198008709 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198008710 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 264198008711 active site 264198008712 FMN binding site [chemical binding]; other site 264198008713 substrate binding site [chemical binding]; other site 264198008714 homotetramer interface [polypeptide binding]; other site 264198008715 catalytic residue [active] 264198008716 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 264198008717 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198008718 acyl-activating enzyme (AAE) consensus motif; other site 264198008719 AMP binding site [chemical binding]; other site 264198008720 active site 264198008721 CoA binding site [chemical binding]; other site 264198008722 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 264198008723 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198008724 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198008725 catalytic residue [active] 264198008726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198008727 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 264198008728 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 264198008729 RNA/DNA hybrid binding site [nucleotide binding]; other site 264198008730 active site 264198008731 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 264198008732 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 264198008733 active site 264198008734 catalytic site [active] 264198008735 substrate binding site [chemical binding]; other site 264198008736 integrase; Provisional; Region: PRK09692 264198008737 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 264198008738 active site 264198008739 Int/Topo IB signature motif; other site 264198008740 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 264198008741 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 264198008742 Protein of unknown function (DUF1484); Region: DUF1484; pfam07363 264198008743 DNA primase domain-containing protein; Region: PHA02415 264198008744 CHC2 zinc finger; Region: zf-CHC2; cl17510 264198008745 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 264198008746 active site 264198008747 metal binding site [ion binding]; metal-binding site 264198008748 interdomain interaction site; other site 264198008749 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198008750 MULE transposase domain; Region: MULE; pfam10551 264198008751 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 264198008752 PAS fold; Region: PAS_4; pfam08448 264198008753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198008754 putative active site [active] 264198008755 heme pocket [chemical binding]; other site 264198008756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198008757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198008758 metal binding site [ion binding]; metal-binding site 264198008759 active site 264198008760 I-site; other site 264198008761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264198008762 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 264198008763 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 264198008764 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264198008765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008766 dimer interface [polypeptide binding]; other site 264198008767 conserved gate region; other site 264198008768 putative PBP binding loops; other site 264198008769 ABC-ATPase subunit interface; other site 264198008770 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264198008771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008772 putative PBP binding loops; other site 264198008773 dimer interface [polypeptide binding]; other site 264198008774 ABC-ATPase subunit interface; other site 264198008775 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 264198008776 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 264198008777 Walker A/P-loop; other site 264198008778 ATP binding site [chemical binding]; other site 264198008779 Q-loop/lid; other site 264198008780 ABC transporter signature motif; other site 264198008781 Walker B; other site 264198008782 D-loop; other site 264198008783 H-loop/switch region; other site 264198008784 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 264198008785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198008786 Walker A/P-loop; other site 264198008787 ATP binding site [chemical binding]; other site 264198008788 Q-loop/lid; other site 264198008789 ABC transporter signature motif; other site 264198008790 Walker B; other site 264198008791 D-loop; other site 264198008792 H-loop/switch region; other site 264198008793 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264198008794 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 264198008795 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264198008796 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 264198008797 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264198008798 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264198008799 putative active site [active] 264198008800 putative substrate binding site [chemical binding]; other site 264198008801 putative cosubstrate binding site; other site 264198008802 catalytic site [active] 264198008803 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264198008804 nudix motif; other site 264198008805 glycerol kinase; Provisional; Region: glpK; PRK00047 264198008806 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 264198008807 N- and C-terminal domain interface [polypeptide binding]; other site 264198008808 active site 264198008809 MgATP binding site [chemical binding]; other site 264198008810 catalytic site [active] 264198008811 metal binding site [ion binding]; metal-binding site 264198008812 glycerol binding site [chemical binding]; other site 264198008813 homotetramer interface [polypeptide binding]; other site 264198008814 homodimer interface [polypeptide binding]; other site 264198008815 FBP binding site [chemical binding]; other site 264198008816 protein IIAGlc interface [polypeptide binding]; other site 264198008817 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 264198008818 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 264198008819 Predicted integral membrane protein [Function unknown]; Region: COG5615 264198008820 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 264198008821 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 264198008822 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 264198008823 dimerization interface [polypeptide binding]; other site 264198008824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198008825 metal binding site [ion binding]; metal-binding site 264198008826 active site 264198008827 I-site; other site 264198008828 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198008829 ligand binding site [chemical binding]; other site 264198008830 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 264198008831 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 264198008832 homodimer interface [polypeptide binding]; other site 264198008833 substrate-cofactor binding pocket; other site 264198008834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198008835 catalytic residue [active] 264198008836 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198008837 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264198008838 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264198008839 putative trimer interface [polypeptide binding]; other site 264198008840 putative CoA binding site [chemical binding]; other site 264198008841 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198008842 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 264198008843 acetyl-CoA synthetase; Provisional; Region: PRK00174 264198008844 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 264198008845 active site 264198008846 CoA binding site [chemical binding]; other site 264198008847 acyl-activating enzyme (AAE) consensus motif; other site 264198008848 AMP binding site [chemical binding]; other site 264198008849 acetate binding site [chemical binding]; other site 264198008850 EamA-like transporter family; Region: EamA; pfam00892 264198008851 hypothetical protein; Provisional; Region: PRK05208 264198008852 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 264198008853 Fumarase C-terminus; Region: Fumerase_C; pfam05683 264198008854 glutamate racemase; Provisional; Region: PRK00865 264198008855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008856 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 264198008857 Walker A motif; other site 264198008858 ATP binding site [chemical binding]; other site 264198008859 Walker B motif; other site 264198008860 arginine finger; other site 264198008861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008862 Walker A motif; other site 264198008863 ATP binding site [chemical binding]; other site 264198008864 Walker B motif; other site 264198008865 arginine finger; other site 264198008866 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 264198008867 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264198008868 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264198008869 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264198008870 TolR protein; Region: tolR; TIGR02801 264198008871 Hemin uptake protein hemP; Region: hemP; pfam10636 264198008872 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 264198008873 Predicted membrane protein [Function unknown]; Region: COG2855 264198008874 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 264198008875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198008876 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264198008877 putative dimerization interface [polypeptide binding]; other site 264198008878 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264198008879 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264198008880 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264198008881 GIY-YIG motif/motif A; other site 264198008882 active site 264198008883 catalytic site [active] 264198008884 putative DNA binding site [nucleotide binding]; other site 264198008885 metal binding site [ion binding]; metal-binding site 264198008886 UvrB/uvrC motif; Region: UVR; pfam02151 264198008887 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264198008888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 264198008889 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 264198008890 elongation factor P; Validated; Region: PRK00529 264198008891 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264198008892 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264198008893 RNA binding site [nucleotide binding]; other site 264198008894 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264198008895 RNA binding site [nucleotide binding]; other site 264198008896 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264198008897 beta-hexosaminidase; Provisional; Region: PRK05337 264198008898 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 264198008899 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 264198008900 active site 264198008901 hydrophilic channel; other site 264198008902 dimerization interface [polypeptide binding]; other site 264198008903 catalytic residues [active] 264198008904 active site lid [active] 264198008905 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 264198008906 Recombination protein O N terminal; Region: RecO_N; pfam11967 264198008907 Recombination protein O C terminal; Region: RecO_C; pfam02565 264198008908 GTPase Era; Reviewed; Region: era; PRK00089 264198008909 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 264198008910 G1 box; other site 264198008911 GTP/Mg2+ binding site [chemical binding]; other site 264198008912 Switch I region; other site 264198008913 G2 box; other site 264198008914 Switch II region; other site 264198008915 G3 box; other site 264198008916 G4 box; other site 264198008917 G5 box; other site 264198008918 KH domain; Region: KH_2; pfam07650 264198008919 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 264198008920 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264198008921 dimerization interface [polypeptide binding]; other site 264198008922 active site 264198008923 metal binding site [ion binding]; metal-binding site 264198008924 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264198008925 signal peptidase I; Provisional; Region: PRK10861 264198008926 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264198008927 Catalytic site [active] 264198008928 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264198008929 GTP-binding protein LepA; Provisional; Region: PRK05433 264198008930 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264198008931 G1 box; other site 264198008932 putative GEF interaction site [polypeptide binding]; other site 264198008933 GTP/Mg2+ binding site [chemical binding]; other site 264198008934 Switch I region; other site 264198008935 G2 box; other site 264198008936 G3 box; other site 264198008937 Switch II region; other site 264198008938 G4 box; other site 264198008939 G5 box; other site 264198008940 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264198008941 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264198008942 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264198008943 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264198008944 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264198008945 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198008946 protein binding site [polypeptide binding]; other site 264198008947 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198008948 protein binding site [polypeptide binding]; other site 264198008949 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 264198008950 anti-sigma E factor; Provisional; Region: rseB; PRK09455 264198008951 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 264198008952 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 264198008953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198008954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198008955 DNA binding residues [nucleotide binding] 264198008956 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 264198008957 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 264198008958 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264198008959 dimer interface [polypeptide binding]; other site 264198008960 active site 264198008961 acyl carrier protein; Provisional; Region: acpP; PRK00982 264198008962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198008963 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198008964 NAD(P) binding site [chemical binding]; other site 264198008965 homotetramer interface [polypeptide binding]; other site 264198008966 homodimer interface [polypeptide binding]; other site 264198008967 active site 264198008968 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264198008969 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264198008970 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264198008971 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264198008972 dimer interface [polypeptide binding]; other site 264198008973 active site 264198008974 CoA binding pocket [chemical binding]; other site 264198008975 putative phosphate acyltransferase; Provisional; Region: PRK05331 264198008976 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 264198008977 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 264198008978 Maf-like protein; Region: Maf; pfam02545 264198008979 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264198008980 active site 264198008981 dimer interface [polypeptide binding]; other site 264198008982 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 264198008983 putative SAM binding site [chemical binding]; other site 264198008984 homodimer interface [polypeptide binding]; other site 264198008985 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264198008986 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 264198008987 tandem repeat interface [polypeptide binding]; other site 264198008988 oligomer interface [polypeptide binding]; other site 264198008989 active site residues [active] 264198008990 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 264198008991 iron-sulfur cluster [ion binding]; other site 264198008992 [2Fe-2S] cluster binding site [ion binding]; other site 264198008993 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264198008994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198008995 motif II; other site 264198008996 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 264198008997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198008998 RNA binding surface [nucleotide binding]; other site 264198008999 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264198009000 active site 264198009001 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 264198009002 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264198009003 homodimer interface [polypeptide binding]; other site 264198009004 oligonucleotide binding site [chemical binding]; other site 264198009005 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 264198009006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198009007 FeS/SAM binding site; other site 264198009008 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 264198009009 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 264198009010 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 264198009011 GTP binding site; other site 264198009012 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264198009013 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264198009014 dimer interface [polypeptide binding]; other site 264198009015 putative functional site; other site 264198009016 putative MPT binding site; other site 264198009017 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 264198009018 RmuC family; Region: RmuC; pfam02646 264198009019 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198009020 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 264198009021 dimerization interface [polypeptide binding]; other site 264198009022 ligand binding site [chemical binding]; other site 264198009023 NADP binding site [chemical binding]; other site 264198009024 catalytic site [active] 264198009025 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 264198009026 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264198009027 transmembrane helices; other site 264198009028 Uncharacterized conserved protein [Function unknown]; Region: COG1556 264198009029 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 264198009030 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 264198009031 active site 264198009032 Ferredoxin [Energy production and conversion]; Region: COG1146 264198009033 4Fe-4S binding domain; Region: Fer4; cl02805 264198009034 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 264198009035 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198009036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198009037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198009038 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 264198009039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009040 active site 264198009041 phosphorylation site [posttranslational modification] 264198009042 intermolecular recognition site; other site 264198009043 dimerization interface [polypeptide binding]; other site 264198009044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198009045 DNA binding site [nucleotide binding] 264198009046 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 264198009047 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 264198009048 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 264198009049 Ligand Binding Site [chemical binding]; other site 264198009050 GAF domain; Region: GAF_3; pfam13492 264198009051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198009052 phosphorylation site [posttranslational modification] 264198009053 dimer interface [polypeptide binding]; other site 264198009054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009055 ATP binding site [chemical binding]; other site 264198009056 Mg2+ binding site [ion binding]; other site 264198009057 G-X-G motif; other site 264198009058 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 264198009059 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 264198009060 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198009061 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 264198009062 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 264198009063 nodulation ABC transporter NodI; Provisional; Region: PRK13537 264198009064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198009065 Walker A/P-loop; other site 264198009066 ATP binding site [chemical binding]; other site 264198009067 Q-loop/lid; other site 264198009068 ABC transporter signature motif; other site 264198009069 Walker B; other site 264198009070 D-loop; other site 264198009071 H-loop/switch region; other site 264198009072 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264198009073 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264198009074 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 264198009075 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198009076 homodimer interface [polypeptide binding]; other site 264198009077 substrate-cofactor binding pocket; other site 264198009078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009079 catalytic residue [active] 264198009080 amidophosphoribosyltransferase; Provisional; Region: PRK09246 264198009081 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 264198009082 active site 264198009083 tetramer interface [polypeptide binding]; other site 264198009084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198009085 active site 264198009086 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 264198009087 Colicin V production protein; Region: Colicin_V; pfam02674 264198009088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 264198009089 Sporulation related domain; Region: SPOR; pfam05036 264198009090 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 264198009091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198009092 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 264198009093 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264198009094 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 264198009095 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 264198009096 substrate binding site [chemical binding]; other site 264198009097 active site 264198009098 catalytic residues [active] 264198009099 heterodimer interface [polypeptide binding]; other site 264198009100 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 264198009101 DNA methylase; Region: N6_N4_Mtase; pfam01555 264198009102 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 264198009103 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 264198009104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009105 catalytic residue [active] 264198009106 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 264198009107 active site 264198009108 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264198009109 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264198009110 dimerization interface 3.5A [polypeptide binding]; other site 264198009111 active site 264198009112 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198009113 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 264198009114 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 264198009115 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264198009116 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 264198009117 tartrate dehydrogenase; Region: TTC; TIGR02089 264198009118 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 264198009119 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264198009120 substrate binding site [chemical binding]; other site 264198009121 Entericidin EcnA/B family; Region: Entericidin; pfam08085 264198009122 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264198009123 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264198009124 substrate binding site [chemical binding]; other site 264198009125 ligand binding site [chemical binding]; other site 264198009126 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198009127 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198009128 Walker A/P-loop; other site 264198009129 ATP binding site [chemical binding]; other site 264198009130 Q-loop/lid; other site 264198009131 ABC transporter signature motif; other site 264198009132 Walker B; other site 264198009133 D-loop; other site 264198009134 H-loop/switch region; other site 264198009135 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 264198009136 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198009137 Walker A/P-loop; other site 264198009138 ATP binding site [chemical binding]; other site 264198009139 Q-loop/lid; other site 264198009140 ABC transporter signature motif; other site 264198009141 Walker B; other site 264198009142 D-loop; other site 264198009143 H-loop/switch region; other site 264198009144 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 264198009145 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 264198009146 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198009147 TM-ABC transporter signature motif; other site 264198009148 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198009149 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198009150 TM-ABC transporter signature motif; other site 264198009151 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198009152 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198009153 dimerization interface [polypeptide binding]; other site 264198009154 ligand binding site [chemical binding]; other site 264198009155 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 264198009156 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198009157 dimer interface [polypeptide binding]; other site 264198009158 active site 264198009159 citrylCoA binding site [chemical binding]; other site 264198009160 NADH binding [chemical binding]; other site 264198009161 cationic pore residues; other site 264198009162 oxalacetate/citrate binding site [chemical binding]; other site 264198009163 coenzyme A binding site [chemical binding]; other site 264198009164 catalytic triad [active] 264198009165 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 264198009166 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 264198009167 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 264198009168 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 264198009169 L-aspartate oxidase; Provisional; Region: PRK06175 264198009170 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264198009171 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 264198009172 SdhC subunit interface [polypeptide binding]; other site 264198009173 proximal heme binding site [chemical binding]; other site 264198009174 cardiolipin binding site; other site 264198009175 Iron-sulfur protein interface; other site 264198009176 proximal quinone binding site [chemical binding]; other site 264198009177 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 264198009178 Iron-sulfur protein interface; other site 264198009179 proximal quinone binding site [chemical binding]; other site 264198009180 SdhD (CybS) interface [polypeptide binding]; other site 264198009181 proximal heme binding site [chemical binding]; other site 264198009182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198009183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009184 DNA-binding site [nucleotide binding]; DNA binding site 264198009185 UTRA domain; Region: UTRA; pfam07702 264198009186 malate dehydrogenase; Provisional; Region: PRK05442 264198009187 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 264198009188 NAD(P) binding site [chemical binding]; other site 264198009189 dimer interface [polypeptide binding]; other site 264198009190 malate binding site [chemical binding]; other site 264198009191 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 264198009192 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198009193 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 264198009194 dimer interface [polypeptide binding]; other site 264198009195 active site 264198009196 citrylCoA binding site [chemical binding]; other site 264198009197 oxalacetate/citrate binding site [chemical binding]; other site 264198009198 coenzyme A binding site [chemical binding]; other site 264198009199 catalytic triad [active] 264198009200 aconitate hydratase; Provisional; Region: acnA; PRK12881 264198009201 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264198009202 substrate binding site [chemical binding]; other site 264198009203 ligand binding site [chemical binding]; other site 264198009204 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 264198009205 substrate binding site [chemical binding]; other site 264198009206 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 264198009207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198009208 S-adenosylmethionine binding site [chemical binding]; other site 264198009209 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 264198009210 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264198009211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264198009212 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198009213 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264198009214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198009215 catalytic residue [active] 264198009216 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 264198009217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198009218 dimerization interface [polypeptide binding]; other site 264198009219 putative DNA binding site [nucleotide binding]; other site 264198009220 putative Zn2+ binding site [ion binding]; other site 264198009221 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 264198009222 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 264198009223 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198009224 C-terminal domain interface [polypeptide binding]; other site 264198009225 GSH binding site (G-site) [chemical binding]; other site 264198009226 dimer interface [polypeptide binding]; other site 264198009227 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 264198009228 N-terminal domain interface [polypeptide binding]; other site 264198009229 dimer interface [polypeptide binding]; other site 264198009230 substrate binding pocket (H-site) [chemical binding]; other site 264198009231 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 264198009232 putative active site [active] 264198009233 heat shock protein 90; Provisional; Region: PRK05218 264198009234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009235 ATP binding site [chemical binding]; other site 264198009236 Mg2+ binding site [ion binding]; other site 264198009237 G-X-G motif; other site 264198009238 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198009239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009240 DNA-binding site [nucleotide binding]; DNA binding site 264198009241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009243 homodimer interface [polypeptide binding]; other site 264198009244 catalytic residue [active] 264198009245 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 264198009246 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 264198009247 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264198009248 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264198009249 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198009250 EamA-like transporter family; Region: EamA; pfam00892 264198009251 EamA-like transporter family; Region: EamA; pfam00892 264198009252 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198009253 homotrimer interaction site [polypeptide binding]; other site 264198009254 putative active site [active] 264198009255 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 264198009256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009258 homodimer interface [polypeptide binding]; other site 264198009259 catalytic residue [active] 264198009260 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198009261 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 264198009262 putative C-terminal domain interface [polypeptide binding]; other site 264198009263 putative GSH binding site (G-site) [chemical binding]; other site 264198009264 putative dimer interface [polypeptide binding]; other site 264198009265 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 264198009266 putative N-terminal domain interface [polypeptide binding]; other site 264198009267 putative dimer interface [polypeptide binding]; other site 264198009268 putative substrate binding pocket (H-site) [chemical binding]; other site 264198009269 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264198009270 L-lactate permease; Region: Lactate_perm; cl00701 264198009271 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 264198009272 Chromate transporter; Region: Chromate_transp; pfam02417 264198009273 Chromate transporter; Region: Chromate_transp; pfam02417 264198009274 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 264198009275 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264198009276 CAP-like domain; other site 264198009277 active site 264198009278 primary dimer interface [polypeptide binding]; other site 264198009279 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009280 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264198009281 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198009282 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198009283 catalytic residue [active] 264198009284 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 264198009285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009286 ATP binding site [chemical binding]; other site 264198009287 Mg2+ binding site [ion binding]; other site 264198009288 G-X-G motif; other site 264198009289 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264198009290 anchoring element; other site 264198009291 dimer interface [polypeptide binding]; other site 264198009292 ATP binding site [chemical binding]; other site 264198009293 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 264198009294 active site 264198009295 metal binding site [ion binding]; metal-binding site 264198009296 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264198009297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198009298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198009299 putative substrate translocation pore; other site 264198009300 ABC transporter ATPase component; Reviewed; Region: PRK11147 264198009301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198009302 Walker A/P-loop; other site 264198009303 ATP binding site [chemical binding]; other site 264198009304 Q-loop/lid; other site 264198009305 ABC transporter signature motif; other site 264198009306 Walker B; other site 264198009307 D-loop; other site 264198009308 H-loop/switch region; other site 264198009309 ABC transporter; Region: ABC_tran_2; pfam12848 264198009310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198009311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198009312 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198009313 substrate binding pocket [chemical binding]; other site 264198009314 membrane-bound complex binding site; other site 264198009315 hinge residues; other site 264198009316 benzoate transporter; Region: benE; TIGR00843 264198009317 Benzoate membrane transport protein; Region: BenE; pfam03594 264198009318 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 264198009319 integrase; Provisional; Region: PRK09692 264198009320 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 264198009321 active site 264198009322 Int/Topo IB signature motif; other site 264198009323 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 264198009324 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 264198009325 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 264198009326 substrate interaction site [chemical binding]; other site 264198009327 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 264198009328 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 264198009329 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 264198009330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198009331 AAA domain; Region: AAA_23; pfam13476 264198009332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198009333 Walker A/P-loop; other site 264198009334 Walker A/P-loop; other site 264198009335 ATP binding site [chemical binding]; other site 264198009336 ATP binding site [chemical binding]; other site 264198009337 Q-loop/lid; other site 264198009338 Ribosome modulation factor; Region: RMF; cl01207 264198009339 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264198009340 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264198009341 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 264198009342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198009343 non-specific DNA binding site [nucleotide binding]; other site 264198009344 salt bridge; other site 264198009345 sequence-specific DNA binding site [nucleotide binding]; other site 264198009346 Predicted transcriptional regulator [Transcription]; Region: COG2932 264198009347 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264198009348 Catalytic site [active] 264198009349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 264198009350 sequence-specific DNA binding site [nucleotide binding]; other site 264198009351 salt bridge; other site 264198009352 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 264198009353 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 264198009354 ParB-like nuclease domain; Region: ParBc; pfam02195 264198009355 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 264198009356 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264198009357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 264198009358 Terminase-like family; Region: Terminase_6; pfam03237 264198009359 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 264198009360 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 264198009361 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 264198009362 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 264198009363 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 264198009364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 264198009365 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 264198009366 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 264198009367 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 264198009368 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 264198009369 Baseplate J-like protein; Region: Baseplate_J; cl01294 264198009370 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 264198009371 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 264198009372 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198009373 catalytic residue [active] 264198009374 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 264198009375 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198009376 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264198009377 Protein phosphatase 2C; Region: PP2C; pfam00481 264198009378 active site 264198009379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198009380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198009381 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 264198009382 putative substrate binding pocket [chemical binding]; other site 264198009383 putative dimerization interface [polypeptide binding]; other site 264198009384 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 264198009385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198009386 catalytic loop [active] 264198009387 iron binding site [ion binding]; other site 264198009388 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198009389 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 264198009390 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 264198009391 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198009392 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009393 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264198009394 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 264198009395 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264198009396 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 264198009397 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 264198009398 active site 264198009399 purine riboside binding site [chemical binding]; other site 264198009400 guanine deaminase; Provisional; Region: PRK09228 264198009401 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 264198009402 active site 264198009403 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 264198009404 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264198009405 putative di-iron ligands [ion binding]; other site 264198009406 Predicted membrane protein [Function unknown]; Region: COG2119 264198009407 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264198009408 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264198009409 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 264198009410 Predicted membrane protein [Function unknown]; Region: COG3748 264198009411 Protein of unknown function (DUF989); Region: DUF989; pfam06181 264198009412 Cytochrome c; Region: Cytochrom_C; pfam00034 264198009413 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264198009414 active site 264198009415 homotetramer interface [polypeptide binding]; other site 264198009416 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198009417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009418 DNA-binding site [nucleotide binding]; DNA binding site 264198009419 FCD domain; Region: FCD; pfam07729 264198009420 xanthine permease; Region: pbuX; TIGR03173 264198009421 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 264198009422 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 264198009423 active site 264198009424 catalytic site [active] 264198009425 tetramer interface [polypeptide binding]; other site 264198009426 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 264198009427 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198009428 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198009429 trimer interface [polypeptide binding]; other site 264198009430 eyelet of channel; other site 264198009431 malic enzyme; Reviewed; Region: PRK12862 264198009432 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264198009433 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264198009434 putative NAD(P) binding site [chemical binding]; other site 264198009435 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264198009436 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 264198009437 aminopeptidase N; Provisional; Region: pepN; PRK14015 264198009438 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 264198009439 active site 264198009440 Zn binding site [ion binding]; other site 264198009441 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 264198009442 AMP binding site [chemical binding]; other site 264198009443 metal binding site [ion binding]; metal-binding site 264198009444 active site 264198009445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198009446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009447 DNA-binding site [nucleotide binding]; DNA binding site 264198009448 FCD domain; Region: FCD; pfam07729 264198009449 benzoate transport; Region: 2A0115; TIGR00895 264198009450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198009451 putative substrate translocation pore; other site 264198009452 hypothetical protein; Provisional; Region: PRK05463 264198009453 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 264198009454 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 264198009455 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 264198009456 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198009457 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198009458 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 264198009459 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198009460 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 264198009461 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198009462 carboxyltransferase (CT) interaction site; other site 264198009463 biotinylation site [posttranslational modification]; other site 264198009464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198009465 PAS domain; Region: PAS_9; pfam13426 264198009466 putative active site [active] 264198009467 heme pocket [chemical binding]; other site 264198009468 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198009469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198009470 dimer interface [polypeptide binding]; other site 264198009471 putative CheW interface [polypeptide binding]; other site 264198009472 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 264198009473 putative hydrophobic ligand binding site [chemical binding]; other site 264198009474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198009475 dimerization interface [polypeptide binding]; other site 264198009476 putative DNA binding site [nucleotide binding]; other site 264198009477 putative Zn2+ binding site [ion binding]; other site 264198009478 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264198009479 Methyltransferase domain; Region: Methyltransf_32; pfam13679 264198009480 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198009481 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 264198009482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198009483 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 264198009484 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 264198009485 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198009486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009487 DNA-binding site [nucleotide binding]; DNA binding site 264198009488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009490 homodimer interface [polypeptide binding]; other site 264198009491 catalytic residue [active] 264198009492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198009493 PAS domain; Region: PAS_9; pfam13426 264198009494 putative active site [active] 264198009495 heme pocket [chemical binding]; other site 264198009496 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198009497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198009498 metal binding site [ion binding]; metal-binding site 264198009499 active site 264198009500 I-site; other site 264198009501 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 264198009502 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 264198009503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 264198009504 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 264198009505 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264198009506 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264198009507 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264198009508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198009509 Zn2+ binding site [ion binding]; other site 264198009510 Mg2+ binding site [ion binding]; other site 264198009511 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264198009512 synthetase active site [active] 264198009513 NTP binding site [chemical binding]; other site 264198009514 metal binding site [ion binding]; metal-binding site 264198009515 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264198009516 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264198009517 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264198009518 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 264198009519 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264198009520 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264198009521 catalytic site [active] 264198009522 G-X2-G-X-G-K; other site 264198009523 hypothetical protein; Provisional; Region: PRK11820 264198009524 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264198009525 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264198009526 Protein kinase domain; Region: Pkinase; pfam00069 264198009527 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264198009528 active site 264198009529 ATP binding site [chemical binding]; other site 264198009530 substrate binding site [chemical binding]; other site 264198009531 activation loop (A-loop); other site 264198009532 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264198009533 Protein phosphatase 2C; Region: PP2C; pfam00481 264198009534 active site 264198009535 ribonuclease PH; Reviewed; Region: rph; PRK00173 264198009536 Ribonuclease PH; Region: RNase_PH_bact; cd11362 264198009537 hexamer interface [polypeptide binding]; other site 264198009538 active site 264198009539 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264198009540 active site 264198009541 dimerization interface [polypeptide binding]; other site 264198009542 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 264198009543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198009544 FeS/SAM binding site; other site 264198009545 HemN C-terminal domain; Region: HemN_C; pfam06969 264198009546 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 264198009547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198009548 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264198009549 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 264198009550 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264198009551 Predicted metal-binding protein [General function prediction only]; Region: COG3019 264198009552 Copper resistance protein D; Region: CopD; cl00563 264198009553 CopC domain; Region: CopC; pfam04234 264198009554 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 264198009555 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 264198009556 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 264198009557 Multicopper oxidase; Region: Cu-oxidase; pfam00394 264198009558 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 264198009559 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 264198009560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009561 active site 264198009562 phosphorylation site [posttranslational modification] 264198009563 intermolecular recognition site; other site 264198009564 dimerization interface [polypeptide binding]; other site 264198009565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198009566 DNA binding site [nucleotide binding] 264198009567 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264198009568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198009569 dimerization interface [polypeptide binding]; other site 264198009570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198009571 dimer interface [polypeptide binding]; other site 264198009572 phosphorylation site [posttranslational modification] 264198009573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009574 ATP binding site [chemical binding]; other site 264198009575 Mg2+ binding site [ion binding]; other site 264198009576 G-X-G motif; other site 264198009577 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 264198009578 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 264198009579 Walker A/P-loop; other site 264198009580 ATP binding site [chemical binding]; other site 264198009581 Q-loop/lid; other site 264198009582 ABC transporter signature motif; other site 264198009583 Walker B; other site 264198009584 D-loop; other site 264198009585 H-loop/switch region; other site 264198009586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 264198009587 FOG: CBS domain [General function prediction only]; Region: COG0517 264198009588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009589 dimer interface [polypeptide binding]; other site 264198009590 conserved gate region; other site 264198009591 ABC-ATPase subunit interface; other site 264198009592 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 264198009593 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 264198009594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009595 dimer interface [polypeptide binding]; other site 264198009596 conserved gate region; other site 264198009597 putative PBP binding loops; other site 264198009598 ABC-ATPase subunit interface; other site 264198009599 Pirin-related protein [General function prediction only]; Region: COG1741 264198009600 Pirin; Region: Pirin; pfam02678 264198009601 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264198009602 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264198009603 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264198009604 Walker A/P-loop; other site 264198009605 ATP binding site [chemical binding]; other site 264198009606 Q-loop/lid; other site 264198009607 ABC transporter signature motif; other site 264198009608 Walker B; other site 264198009609 D-loop; other site 264198009610 H-loop/switch region; other site 264198009611 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264198009612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198009613 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264198009614 TM-ABC transporter signature motif; other site 264198009615 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264198009616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198009617 TM-ABC transporter signature motif; other site 264198009618 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 264198009619 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264198009620 putative ligand binding site [chemical binding]; other site 264198009621 Uncharacterized conserved protein [Function unknown]; Region: COG3339 264198009622 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198009623 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198009624 NADP binding site [chemical binding]; other site 264198009625 dimer interface [polypeptide binding]; other site 264198009626 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 264198009627 active site 264198009628 dimer interfaces [polypeptide binding]; other site 264198009629 catalytic residues [active] 264198009630 short chain dehydrogenase; Provisional; Region: PRK08339 264198009631 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 264198009632 putative NAD(P) binding site [chemical binding]; other site 264198009633 putative active site [active] 264198009634 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198009635 EamA-like transporter family; Region: EamA; pfam00892 264198009636 EamA-like transporter family; Region: EamA; pfam00892 264198009637 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198009638 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198009639 MarR family; Region: MarR_2; pfam12802 264198009640 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009641 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198009642 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198009643 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009644 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198009646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198009647 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 264198009648 Isochorismatase family; Region: Isochorismatase; pfam00857 264198009649 catalytic triad [active] 264198009650 substrate binding site [chemical binding]; other site 264198009651 domain interfaces; other site 264198009652 conserved cis-peptide bond; other site 264198009653 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 264198009654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198009655 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198009656 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198009657 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198009658 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198009659 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198009660 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198009661 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198009662 benzoate transport; Region: 2A0115; TIGR00895 264198009663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198009664 putative substrate translocation pore; other site 264198009665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198009666 active site 264198009667 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 264198009668 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 264198009669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009670 Walker A motif; other site 264198009671 ATP binding site [chemical binding]; other site 264198009672 hypothetical protein; Validated; Region: PRK00110 264198009673 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264198009674 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264198009675 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 264198009676 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264198009677 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 264198009678 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 264198009679 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 264198009680 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264198009681 active site 264198009682 (T/H)XGH motif; other site 264198009683 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 264198009684 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 264198009685 Maf-like protein; Region: Maf; pfam02545 264198009686 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264198009687 active site 264198009688 dimer interface [polypeptide binding]; other site 264198009689 ribonuclease G; Provisional; Region: PRK11712 264198009690 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264198009691 homodimer interface [polypeptide binding]; other site 264198009692 oligonucleotide binding site [chemical binding]; other site 264198009693 alanine racemase; Reviewed; Region: dadX; PRK03646 264198009694 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 264198009695 active site 264198009696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198009697 substrate binding site [chemical binding]; other site 264198009698 catalytic residues [active] 264198009699 dimer interface [polypeptide binding]; other site 264198009700 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 264198009701 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 264198009702 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198009703 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198009704 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 264198009705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264198009706 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 264198009707 Walker A/P-loop; other site 264198009708 ATP binding site [chemical binding]; other site 264198009709 Q-loop/lid; other site 264198009710 ABC transporter signature motif; other site 264198009711 Walker B; other site 264198009712 D-loop; other site 264198009713 H-loop/switch region; other site 264198009714 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 264198009715 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 264198009716 putative active site [active] 264198009717 putative PHP Thumb interface [polypeptide binding]; other site 264198009718 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264198009719 generic binding surface II; other site 264198009720 generic binding surface I; other site 264198009721 rhodanese superfamily protein; Provisional; Region: PRK05320 264198009722 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 264198009723 active site residue [active] 264198009724 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 264198009725 putative active site [active] 264198009726 putative CoA binding site [chemical binding]; other site 264198009727 nudix motif; other site 264198009728 metal binding site [ion binding]; metal-binding site 264198009729 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 264198009730 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 264198009731 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264198009732 RimM N-terminal domain; Region: RimM; pfam01782 264198009733 PRC-barrel domain; Region: PRC; pfam05239 264198009734 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 264198009735 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264198009736 TM2 domain; Region: TM2; pfam05154 264198009737 transcriptional activator TtdR; Provisional; Region: PRK09801 264198009738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198009739 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198009740 putative effector binding pocket; other site 264198009741 dimerization interface [polypeptide binding]; other site 264198009742 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 264198009743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198009744 FeS/SAM binding site; other site 264198009745 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 264198009746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198009747 putative DNA binding site [nucleotide binding]; other site 264198009748 putative Zn2+ binding site [ion binding]; other site 264198009749 AsnC family; Region: AsnC_trans_reg; pfam01037 264198009750 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 264198009751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198009752 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198009753 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198009754 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198009755 active site 264198009756 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198009757 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 264198009758 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 264198009759 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264198009760 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 264198009761 Ligand binding site [chemical binding]; other site 264198009762 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264198009763 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 264198009764 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 264198009765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009766 ABC-ATPase subunit interface; other site 264198009767 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 264198009768 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 264198009769 Walker A/P-loop; other site 264198009770 ATP binding site [chemical binding]; other site 264198009771 Q-loop/lid; other site 264198009772 ABC transporter signature motif; other site 264198009773 Walker B; other site 264198009774 D-loop; other site 264198009775 H-loop/switch region; other site 264198009776 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 264198009777 enoyl-CoA hydratase; Validated; Region: PRK08139 264198009778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198009779 substrate binding site [chemical binding]; other site 264198009780 oxyanion hole (OAH) forming residues; other site 264198009781 trimer interface [polypeptide binding]; other site 264198009782 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 264198009783 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 264198009784 putative active site [active] 264198009785 Zn binding site [ion binding]; other site 264198009786 Transglycosylase SLT domain; Region: SLT_2; pfam13406 264198009787 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198009788 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198009789 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198009790 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198009791 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 264198009792 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 264198009793 Ligand binding site; other site 264198009794 metal-binding site 264198009795 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 264198009796 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198009797 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198009798 putative active site [active] 264198009799 cysteine synthase B; Region: cysM; TIGR01138 264198009800 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198009801 dimer interface [polypeptide binding]; other site 264198009802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009803 catalytic residue [active] 264198009804 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 264198009805 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 264198009806 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 264198009807 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 264198009808 NADP binding site [chemical binding]; other site 264198009809 homopentamer interface [polypeptide binding]; other site 264198009810 substrate binding site [chemical binding]; other site 264198009811 active site 264198009812 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198009813 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 264198009814 putative ribose interaction site [chemical binding]; other site 264198009815 putative ADP binding site [chemical binding]; other site 264198009816 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 264198009817 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264198009818 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264198009819 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 264198009820 tetratricopeptide repeat protein; Provisional; Region: PRK11788 264198009821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198009822 binding surface 264198009823 TPR motif; other site 264198009824 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198009825 IHF dimer interface [polypeptide binding]; other site 264198009826 IHF - DNA interface [nucleotide binding]; other site 264198009827 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 264198009828 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264198009829 RNA binding site [nucleotide binding]; other site 264198009830 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264198009831 RNA binding site [nucleotide binding]; other site 264198009832 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 264198009833 RNA binding site [nucleotide binding]; other site 264198009834 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 264198009835 RNA binding site [nucleotide binding]; other site 264198009836 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 264198009837 RNA binding site [nucleotide binding]; other site 264198009838 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 264198009839 RNA binding site [nucleotide binding]; other site 264198009840 cytidylate kinase; Provisional; Region: cmk; PRK00023 264198009841 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264198009842 CMP-binding site; other site 264198009843 The sites determining sugar specificity; other site 264198009844 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 264198009845 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 264198009846 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 264198009847 hinge; other site 264198009848 active site 264198009849 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 264198009850 prephenate dehydrogenase; Validated; Region: PRK08507 264198009851 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 264198009852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009854 homodimer interface [polypeptide binding]; other site 264198009855 catalytic residue [active] 264198009856 Chorismate mutase type II; Region: CM_2; cl00693 264198009857 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 264198009858 Prephenate dehydratase; Region: PDT; pfam00800 264198009859 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 264198009860 putative L-Phe binding site [chemical binding]; other site 264198009861 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 264198009862 homodimer interface [polypeptide binding]; other site 264198009863 substrate-cofactor binding pocket; other site 264198009864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009865 catalytic residue [active] 264198009866 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 264198009867 DNA gyrase subunit A; Validated; Region: PRK05560 264198009868 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264198009869 CAP-like domain; other site 264198009870 active site 264198009871 primary dimer interface [polypeptide binding]; other site 264198009872 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009873 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009874 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009875 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009878 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198009879 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198009880 ligand binding site [chemical binding]; other site 264198009881 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 264198009882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198009883 S-adenosylmethionine binding site [chemical binding]; other site 264198009884 phosphoglycolate phosphatase; Provisional; Region: PRK13222 264198009885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198009886 motif II; other site 264198009887 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 264198009888 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264198009889 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264198009890 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 264198009891 Walker A/P-loop; other site 264198009892 ATP binding site [chemical binding]; other site 264198009893 Q-loop/lid; other site 264198009894 ABC transporter signature motif; other site 264198009895 Walker B; other site 264198009896 D-loop; other site 264198009897 H-loop/switch region; other site 264198009898 cyanophycin synthetase; Provisional; Region: PRK14016 264198009899 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264198009900 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198009901 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198009902 cyanophycin synthetase; Provisional; Region: PRK14016 264198009903 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 264198009904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198009905 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198009906 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198009907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009908 dimer interface [polypeptide binding]; other site 264198009909 conserved gate region; other site 264198009910 putative PBP binding loops; other site 264198009911 ABC-ATPase subunit interface; other site 264198009912 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198009913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198009914 substrate binding pocket [chemical binding]; other site 264198009915 membrane-bound complex binding site; other site 264198009916 hinge residues; other site 264198009917 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 264198009918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198009919 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 264198009920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198009921 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 264198009922 putative dimerization interface [polypeptide binding]; other site 264198009923 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264198009924 Domain of unknown function DUF21; Region: DUF21; pfam01595 264198009925 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264198009926 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 264198009927 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 264198009928 active site 264198009929 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264198009930 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 264198009931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 264198009932 seryl-tRNA synthetase; Provisional; Region: PRK05431 264198009933 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264198009934 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 264198009935 dimer interface [polypeptide binding]; other site 264198009936 active site 264198009937 motif 1; other site 264198009938 motif 2; other site 264198009939 motif 3; other site 264198009940 recombination factor protein RarA; Reviewed; Region: PRK13342 264198009941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009942 Walker A motif; other site 264198009943 ATP binding site [chemical binding]; other site 264198009944 Walker B motif; other site 264198009945 arginine finger; other site 264198009946 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264198009947 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 264198009948 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 264198009949 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 264198009950 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264198009951 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264198009952 thioredoxin reductase; Provisional; Region: PRK10262 264198009953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198009954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198009955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 264198009956 Smr domain; Region: Smr; pfam01713 264198009957 Predicted membrane protein [Function unknown]; Region: COG2860 264198009958 UPF0126 domain; Region: UPF0126; pfam03458 264198009959 UPF0126 domain; Region: UPF0126; pfam03458 264198009960 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 264198009961 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264198009962 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198009963 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198009964 conserved cys residue [active] 264198009965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198009966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198009967 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 264198009968 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 264198009969 gating phenylalanine in ion channel; other site 264198009970 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 264198009971 NAD synthetase; Reviewed; Region: nadE; PRK02628 264198009972 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 264198009973 multimer interface [polypeptide binding]; other site 264198009974 active site 264198009975 catalytic triad [active] 264198009976 protein interface 1 [polypeptide binding]; other site 264198009977 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264198009978 homodimer interface [polypeptide binding]; other site 264198009979 NAD binding pocket [chemical binding]; other site 264198009980 ATP binding pocket [chemical binding]; other site 264198009981 Mg binding site [ion binding]; other site 264198009982 active-site loop [active] 264198009983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 264198009984 Protein of unknown function, DUF482; Region: DUF482; pfam04339 264198009985 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 264198009986 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 264198009987 dimer interface [polypeptide binding]; other site 264198009988 substrate binding site [chemical binding]; other site 264198009989 metal binding sites [ion binding]; metal-binding site 264198009990 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198009991 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 264198009992 NAD(P) binding site [chemical binding]; other site 264198009993 catalytic residues [active] 264198009994 catalytic residues [active] 264198009995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009996 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198009997 NAD(P) binding site [chemical binding]; other site 264198009998 active site 264198009999 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198010000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198010001 putative substrate translocation pore; other site 264198010002 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198010003 putative binding surface; other site 264198010004 active site 264198010005 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198010006 putative binding surface; other site 264198010007 active site 264198010008 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198010009 putative binding surface; other site 264198010010 active site 264198010011 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264198010012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010013 ATP binding site [chemical binding]; other site 264198010014 Mg2+ binding site [ion binding]; other site 264198010015 G-X-G motif; other site 264198010016 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198010017 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010019 active site 264198010020 phosphorylation site [posttranslational modification] 264198010021 intermolecular recognition site; other site 264198010022 dimerization interface [polypeptide binding]; other site 264198010023 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 264198010024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198010025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198010026 dimer interface [polypeptide binding]; other site 264198010027 putative CheW interface [polypeptide binding]; other site 264198010028 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264198010029 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010031 active site 264198010032 phosphorylation site [posttranslational modification] 264198010033 intermolecular recognition site; other site 264198010034 dimerization interface [polypeptide binding]; other site 264198010035 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010037 active site 264198010038 phosphorylation site [posttranslational modification] 264198010039 intermolecular recognition site; other site 264198010040 dimerization interface [polypeptide binding]; other site 264198010041 Rubredoxin [Energy production and conversion]; Region: COG1773 264198010042 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264198010043 iron binding site [ion binding]; other site 264198010044 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 264198010045 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198010046 inhibitor-cofactor binding pocket; inhibition site 264198010047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198010048 catalytic residue [active] 264198010049 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 264198010050 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 264198010051 Repair protein; Region: Repair_PSII; pfam04536 264198010052 Repair protein; Region: Repair_PSII; cl01535 264198010053 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 264198010054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198010055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198010056 putative substrate translocation pore; other site 264198010057 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 264198010058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010059 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198010060 dimerization interface [polypeptide binding]; other site 264198010061 substrate binding pocket [chemical binding]; other site 264198010062 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 264198010063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010064 Walker A motif; other site 264198010065 ATP binding site [chemical binding]; other site 264198010066 Walker B motif; other site 264198010067 arginine finger; other site 264198010068 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198010069 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264198010070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010071 S-adenosylmethionine binding site [chemical binding]; other site 264198010072 Predicted membrane protein [Function unknown]; Region: COG2246 264198010073 GtrA-like protein; Region: GtrA; pfam04138 264198010074 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264198010075 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264198010076 Ligand binding site; other site 264198010077 Putative Catalytic site; other site 264198010078 DXD motif; other site 264198010079 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 264198010080 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 264198010081 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 264198010082 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 264198010083 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 264198010084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010085 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198010086 Walker A motif; other site 264198010087 ATP binding site [chemical binding]; other site 264198010088 Walker B motif; other site 264198010089 arginine finger; other site 264198010090 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 264198010091 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264198010092 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 264198010093 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 264198010094 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198010095 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 264198010096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010097 intermolecular recognition site; other site 264198010098 active site 264198010099 dimerization interface [polypeptide binding]; other site 264198010100 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 264198010101 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 264198010102 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264198010103 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264198010104 ATP binding site [chemical binding]; other site 264198010105 Walker A motif; other site 264198010106 hexamer interface [polypeptide binding]; other site 264198010107 Walker B motif; other site 264198010108 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 264198010109 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198010110 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 264198010111 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198010112 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 264198010113 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198010114 putative active site [active] 264198010115 putative metal binding site [ion binding]; other site 264198010116 spermidine synthase; Provisional; Region: PRK03612 264198010117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010118 S-adenosylmethionine binding site [chemical binding]; other site 264198010119 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264198010120 TadE-like protein; Region: TadE; pfam07811 264198010121 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 264198010122 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264198010123 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264198010124 ring oligomerisation interface [polypeptide binding]; other site 264198010125 ATP/Mg binding site [chemical binding]; other site 264198010126 stacking interactions; other site 264198010127 hinge regions; other site 264198010128 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264198010129 oligomerisation interface [polypeptide binding]; other site 264198010130 mobile loop; other site 264198010131 roof hairpin; other site 264198010132 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 264198010133 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198010134 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198010135 catalytic residue [active] 264198010136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264198010137 dimerization interface [polypeptide binding]; other site 264198010138 putative DNA binding site [nucleotide binding]; other site 264198010139 putative Zn2+ binding site [ion binding]; other site 264198010140 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198010141 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198010142 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198010143 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198010144 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 264198010145 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198010146 catalytic loop [active] 264198010147 iron binding site [ion binding]; other site 264198010148 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198010149 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264198010150 Cytochrome c; Region: Cytochrom_C; pfam00034 264198010151 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198010152 MASE1; Region: MASE1; pfam05231 264198010153 putative diguanylate cyclase; Provisional; Region: PRK09776 264198010154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198010155 putative active site [active] 264198010156 heme pocket [chemical binding]; other site 264198010157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198010158 heme pocket [chemical binding]; other site 264198010159 putative active site [active] 264198010160 PAS domain; Region: PAS; smart00091 264198010161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198010162 metal binding site [ion binding]; metal-binding site 264198010163 active site 264198010164 I-site; other site 264198010165 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198010166 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198010167 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 264198010168 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264198010169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198010170 dimer interface [polypeptide binding]; other site 264198010171 phosphorylation site [posttranslational modification] 264198010172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010173 ATP binding site [chemical binding]; other site 264198010174 Mg2+ binding site [ion binding]; other site 264198010175 G-X-G motif; other site 264198010176 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198010177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010178 active site 264198010179 phosphorylation site [posttranslational modification] 264198010180 intermolecular recognition site; other site 264198010181 dimerization interface [polypeptide binding]; other site 264198010182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010183 Walker A motif; other site 264198010184 ATP binding site [chemical binding]; other site 264198010185 Walker B motif; other site 264198010186 arginine finger; other site 264198010187 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198010188 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 264198010189 DNA binding residues [nucleotide binding] 264198010190 ornithine cyclodeaminase; Validated; Region: PRK07589 264198010191 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 264198010192 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 264198010193 Amidinotransferase; Region: Amidinotransf; cl12043 264198010194 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198010195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198010196 putative DNA binding site [nucleotide binding]; other site 264198010197 putative Zn2+ binding site [ion binding]; other site 264198010198 AsnC family; Region: AsnC_trans_reg; pfam01037 264198010199 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 264198010200 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 264198010201 Cl- selectivity filter; other site 264198010202 Cl- binding residues [ion binding]; other site 264198010203 pore gating glutamate residue; other site 264198010204 dimer interface [polypeptide binding]; other site 264198010205 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264198010206 FOG: CBS domain [General function prediction only]; Region: COG0517 264198010207 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 264198010208 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 264198010209 HPP family; Region: HPP; pfam04982 264198010210 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264198010211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 264198010212 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264198010213 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 264198010214 Paraquat-inducible protein A; Region: PqiA; pfam04403 264198010215 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 264198010216 Paraquat-inducible protein A; Region: PqiA; pfam04403 264198010217 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 264198010218 mce related protein; Region: MCE; pfam02470 264198010219 mce related protein; Region: MCE; pfam02470 264198010220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 264198010221 Protein of unknown function (DUF330); Region: DUF330; pfam03886 264198010222 DNA polymerase III subunit chi; Validated; Region: PRK05728 264198010223 multifunctional aminopeptidase A; Provisional; Region: PRK00913 264198010224 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 264198010225 interface (dimer of trimers) [polypeptide binding]; other site 264198010226 Substrate-binding/catalytic site; other site 264198010227 Zn-binding sites [ion binding]; other site 264198010228 Predicted permeases [General function prediction only]; Region: COG0795 264198010229 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264198010230 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264198010231 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 264198010232 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 264198010233 putative active site [active] 264198010234 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 264198010235 hypothetical protein; Provisional; Region: PRK05409 264198010236 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 264198010237 Predicted membrane protein [Function unknown]; Region: COG2259 264198010238 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 264198010239 active site 264198010240 SAM binding site [chemical binding]; other site 264198010241 homodimer interface [polypeptide binding]; other site 264198010242 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 264198010243 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 264198010244 CysD dimerization site [polypeptide binding]; other site 264198010245 G1 box; other site 264198010246 putative GEF interaction site [polypeptide binding]; other site 264198010247 GTP/Mg2+ binding site [chemical binding]; other site 264198010248 Switch I region; other site 264198010249 G2 box; other site 264198010250 G3 box; other site 264198010251 Switch II region; other site 264198010252 G4 box; other site 264198010253 G5 box; other site 264198010254 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 264198010255 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 264198010256 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 264198010257 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264198010258 Active Sites [active] 264198010259 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 264198010260 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264198010261 Active Sites [active] 264198010262 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 264198010263 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 264198010264 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198010265 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198010266 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198010267 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 264198010268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010269 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 264198010270 substrate binding site [chemical binding]; other site 264198010271 dimerization interface [polypeptide binding]; other site 264198010272 Methyltransferase domain; Region: Methyltransf_23; pfam13489 264198010273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010274 S-adenosylmethionine binding site [chemical binding]; other site 264198010275 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198010276 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 264198010277 putative ligand binding site [chemical binding]; other site 264198010278 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198010279 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198010280 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 264198010281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 264198010282 active site 264198010283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010284 S-adenosylmethionine binding site [chemical binding]; other site 264198010285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198010286 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 264198010287 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 264198010288 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 264198010289 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264198010290 TrkA-C domain; Region: TrkA_C; pfam02080 264198010291 TrkA-C domain; Region: TrkA_C; pfam02080 264198010292 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264198010293 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 264198010294 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264198010295 TrkA-C domain; Region: TrkA_C; pfam02080 264198010296 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 264198010297 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 264198010298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198010299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198010300 homodimer interface [polypeptide binding]; other site 264198010301 catalytic residue [active] 264198010302 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 264198010303 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 264198010304 putative active site [active] 264198010305 catalytic site [active] 264198010306 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 264198010307 putative active site [active] 264198010308 catalytic site [active] 264198010309 N-formylglutamate amidohydrolase; Region: FGase; cl01522 264198010310 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 264198010311 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198010312 active site 264198010313 imidazolonepropionase; Validated; Region: PRK09356 264198010314 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 264198010315 active site 264198010316 HutD; Region: HutD; pfam05962 264198010317 urocanate hydratase; Provisional; Region: PRK05414 264198010318 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264198010319 active sites [active] 264198010320 tetramer interface [polypeptide binding]; other site 264198010321 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 264198010322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198010323 DNA-binding site [nucleotide binding]; DNA binding site 264198010324 UTRA domain; Region: UTRA; pfam07702 264198010325 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198010326 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198010327 Walker A/P-loop; other site 264198010328 ATP binding site [chemical binding]; other site 264198010329 Q-loop/lid; other site 264198010330 ABC transporter signature motif; other site 264198010331 Walker B; other site 264198010332 D-loop; other site 264198010333 H-loop/switch region; other site 264198010334 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198010335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010336 dimer interface [polypeptide binding]; other site 264198010337 conserved gate region; other site 264198010338 putative PBP binding loops; other site 264198010339 ABC-ATPase subunit interface; other site 264198010340 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198010341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198010342 substrate binding pocket [chemical binding]; other site 264198010343 membrane-bound complex binding site; other site 264198010344 hinge residues; other site 264198010345 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198010346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010347 NAD(P) binding site [chemical binding]; other site 264198010348 active site 264198010349 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198010350 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198010351 catalytic loop [active] 264198010352 iron binding site [ion binding]; other site 264198010353 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 264198010354 FAD binding pocket [chemical binding]; other site 264198010355 FAD binding motif [chemical binding]; other site 264198010356 phosphate binding motif [ion binding]; other site 264198010357 beta-alpha-beta structure motif; other site 264198010358 NAD binding pocket [chemical binding]; other site 264198010359 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 264198010360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198010361 inhibitor-cofactor binding pocket; inhibition site 264198010362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198010363 catalytic residue [active] 264198010364 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 264198010365 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198010366 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198010367 Walker A/P-loop; other site 264198010368 ATP binding site [chemical binding]; other site 264198010369 Q-loop/lid; other site 264198010370 ABC transporter signature motif; other site 264198010371 Walker B; other site 264198010372 D-loop; other site 264198010373 H-loop/switch region; other site 264198010374 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198010375 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198010376 Walker A/P-loop; other site 264198010377 ATP binding site [chemical binding]; other site 264198010378 Q-loop/lid; other site 264198010379 ABC transporter signature motif; other site 264198010380 Walker B; other site 264198010381 D-loop; other site 264198010382 H-loop/switch region; other site 264198010383 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198010384 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198010385 TM-ABC transporter signature motif; other site 264198010386 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198010387 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198010388 TM-ABC transporter signature motif; other site 264198010389 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198010390 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198010391 dimerization interface [polypeptide binding]; other site 264198010392 ligand binding site [chemical binding]; other site 264198010393 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 264198010394 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 264198010395 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264198010396 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264198010397 hypothetical protein; Reviewed; Region: PRK00024 264198010398 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264198010399 MPN+ (JAMM) motif; other site 264198010400 Zinc-binding site [ion binding]; other site 264198010401 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 264198010402 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 264198010403 L-aspartate oxidase; Provisional; Region: PRK09077 264198010404 L-aspartate oxidase; Provisional; Region: PRK06175 264198010405 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264198010406 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 264198010407 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264198010408 dimerization interface [polypeptide binding]; other site 264198010409 active site 264198010410 quinolinate synthetase; Provisional; Region: PRK09375 264198010411 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264198010412 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 264198010413 Di-iron ligands [ion binding]; other site 264198010414 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264198010415 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 264198010416 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198010417 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 264198010418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010419 S-adenosylmethionine binding site [chemical binding]; other site 264198010420 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 264198010421 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264198010422 active site 264198010423 substrate binding site [chemical binding]; other site 264198010424 cosubstrate binding site; other site 264198010425 catalytic site [active] 264198010426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198010427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010428 active site 264198010429 phosphorylation site [posttranslational modification] 264198010430 intermolecular recognition site; other site 264198010431 dimerization interface [polypeptide binding]; other site 264198010432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198010433 DNA binding residues [nucleotide binding] 264198010434 dimerization interface [polypeptide binding]; other site 264198010435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198010436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198010437 dimer interface [polypeptide binding]; other site 264198010438 phosphorylation site [posttranslational modification] 264198010439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010440 ATP binding site [chemical binding]; other site 264198010441 Mg2+ binding site [ion binding]; other site 264198010442 G-X-G motif; other site 264198010443 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264198010444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010445 active site 264198010446 phosphorylation site [posttranslational modification] 264198010447 intermolecular recognition site; other site 264198010448 dimerization interface [polypeptide binding]; other site 264198010449 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264198010450 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264198010451 active site 264198010452 Riboflavin kinase; Region: Flavokinase; smart00904 264198010453 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 264198010454 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198010455 active site 264198010456 HIGH motif; other site 264198010457 nucleotide binding site [chemical binding]; other site 264198010458 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264198010459 active site 264198010460 KMSKS motif; other site 264198010461 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 264198010462 tRNA binding surface [nucleotide binding]; other site 264198010463 anticodon binding site; other site 264198010464 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264198010465 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 264198010466 lipoprotein signal peptidase; Provisional; Region: PRK14787 264198010467 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 264198010468 Flavoprotein; Region: Flavoprotein; pfam02441 264198010469 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 264198010470 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 264198010471 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 264198010472 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 264198010473 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264198010474 trimer interface [polypeptide binding]; other site 264198010475 active site 264198010476 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 264198010477 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198010478 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 264198010479 Clp amino terminal domain; Region: Clp_N; pfam02861 264198010480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010481 Walker A motif; other site 264198010482 ATP binding site [chemical binding]; other site 264198010483 Walker B motif; other site 264198010484 arginine finger; other site 264198010485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010486 Walker A motif; other site 264198010487 ATP binding site [chemical binding]; other site 264198010488 Walker B motif; other site 264198010489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264198010490 Uncharacterized conserved protein [Function unknown]; Region: COG2127 264198010491 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198010492 DNA-binding site [nucleotide binding]; DNA binding site 264198010493 RNA-binding motif; other site 264198010494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 264198010495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198010496 isocitrate dehydrogenase; Validated; Region: PRK07362 264198010497 isocitrate dehydrogenase; Reviewed; Region: PRK07006 264198010498 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264198010499 pseudouridine synthase; Region: TIGR00093 264198010500 active site 264198010501 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 264198010502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 264198010503 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 264198010504 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 264198010505 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010506 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264198010507 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 264198010508 ornithine carbamoyltransferase; Provisional; Region: PRK00779 264198010509 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264198010510 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 264198010511 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 264198010512 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 264198010513 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264198010514 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264198010515 Uncharacterized conserved protein [Function unknown]; Region: COG2912 264198010516 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 264198010517 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264198010518 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264198010519 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264198010520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010521 ATP binding site [chemical binding]; other site 264198010522 Mg2+ binding site [ion binding]; other site 264198010523 G-X-G motif; other site 264198010524 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 264198010525 ATP binding site [chemical binding]; other site 264198010526 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 264198010527 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264198010528 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264198010529 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198010530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198010532 dimerization interface [polypeptide binding]; other site 264198010533 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 264198010534 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 264198010535 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 264198010536 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 264198010537 dimerization interface [polypeptide binding]; other site 264198010538 putative ATP binding site [chemical binding]; other site 264198010539 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264198010540 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 264198010541 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 264198010542 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264198010543 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264198010544 poly(A) polymerase; Region: pcnB; TIGR01942 264198010545 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264198010546 active site 264198010547 NTP binding site [chemical binding]; other site 264198010548 metal binding triad [ion binding]; metal-binding site 264198010549 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264198010550 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 264198010551 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264198010552 catalytic center binding site [active] 264198010553 ATP binding site [chemical binding]; other site 264198010554 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 264198010555 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 264198010556 Substrate-binding site [chemical binding]; other site 264198010557 Substrate specificity [chemical binding]; other site 264198010558 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 264198010559 oligomerization interface [polypeptide binding]; other site 264198010560 active site 264198010561 metal binding site [ion binding]; metal-binding site 264198010562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010563 dimer interface [polypeptide binding]; other site 264198010564 conserved gate region; other site 264198010565 putative PBP binding loops; other site 264198010566 ABC-ATPase subunit interface; other site 264198010567 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 264198010568 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 264198010569 Walker A/P-loop; other site 264198010570 ATP binding site [chemical binding]; other site 264198010571 Q-loop/lid; other site 264198010572 ABC transporter signature motif; other site 264198010573 Walker B; other site 264198010574 D-loop; other site 264198010575 H-loop/switch region; other site 264198010576 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 264198010577 chorismate binding enzyme; Region: Chorismate_bind; cl10555 264198010578 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 264198010579 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 264198010580 substrate-cofactor binding pocket; other site 264198010581 homodimer interface [polypeptide binding]; other site 264198010582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198010583 catalytic residue [active] 264198010584 chaperone protein DnaJ; Provisional; Region: PRK10767 264198010585 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198010586 HSP70 interaction site [polypeptide binding]; other site 264198010587 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 264198010588 substrate binding site [polypeptide binding]; other site 264198010589 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264198010590 Zn binding sites [ion binding]; other site 264198010591 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264198010592 dimer interface [polypeptide binding]; other site 264198010593 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264198010594 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 264198010595 nucleotide binding site [chemical binding]; other site 264198010596 NEF interaction site [polypeptide binding]; other site 264198010597 SBD interface [polypeptide binding]; other site 264198010598 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 264198010599 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198010600 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010601 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198010602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010603 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198010604 dimerization interface [polypeptide binding]; other site 264198010605 substrate binding pocket [chemical binding]; other site 264198010606 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264198010607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198010608 Coenzyme A binding pocket [chemical binding]; other site 264198010609 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 264198010610 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010611 Ion transport protein; Region: Ion_trans; pfam00520 264198010612 Ion channel; Region: Ion_trans_2; pfam07885 264198010613 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198010614 Double zinc ribbon; Region: DZR; pfam12773 264198010615 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 264198010616 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010617 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 264198010618 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198010619 Cysteine-rich domain; Region: CCG; pfam02754 264198010620 Cysteine-rich domain; Region: CCG; pfam02754 264198010621 LrgA family; Region: LrgA; pfam03788 264198010622 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 264198010623 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 264198010624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198010625 Predicted transcriptional regulator [Transcription]; Region: COG2378 264198010626 HTH domain; Region: HTH_11; pfam08279 264198010627 WYL domain; Region: WYL; pfam13280 264198010628 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264198010629 catalytic residues [active] 264198010630 dimer interface [polypeptide binding]; other site 264198010631 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 264198010632 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264198010633 Walker A motif; other site 264198010634 ATP binding site [chemical binding]; other site 264198010635 Walker B motif; other site 264198010636 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 264198010637 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264198010638 Walker A motif; other site 264198010639 ATP binding site [chemical binding]; other site 264198010640 Walker B motif; other site 264198010641 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 264198010642 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198010643 catalytic residue [active] 264198010644 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 264198010645 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 264198010646 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 264198010647 UbiA prenyltransferase family; Region: UbiA; pfam01040 264198010648 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 264198010649 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264198010650 dimerization interface [polypeptide binding]; other site 264198010651 DPS ferroxidase diiron center [ion binding]; other site 264198010652 ion pore; other site 264198010653 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 264198010654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010655 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 264198010656 dimerization interface [polypeptide binding]; other site 264198010657 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264198010658 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264198010659 generic binding surface II; other site 264198010660 ssDNA binding site; other site 264198010661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198010662 ATP binding site [chemical binding]; other site 264198010663 putative Mg++ binding site [ion binding]; other site 264198010664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198010665 nucleotide binding region [chemical binding]; other site 264198010666 ATP-binding site [chemical binding]; other site 264198010667 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 264198010668 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 264198010669 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 264198010670 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264198010671 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 264198010672 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 264198010673 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 264198010674 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 264198010675 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264198010676 Protein export membrane protein; Region: SecD_SecF; pfam02355 264198010677 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010679 active site 264198010680 phosphorylation site [posttranslational modification] 264198010681 intermolecular recognition site; other site 264198010682 dimerization interface [polypeptide binding]; other site 264198010683 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010685 active site 264198010686 phosphorylation site [posttranslational modification] 264198010687 intermolecular recognition site; other site 264198010688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198010689 dimerization interface [polypeptide binding]; other site 264198010690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198010691 dimer interface [polypeptide binding]; other site 264198010692 phosphorylation site [posttranslational modification] 264198010693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010694 ATP binding site [chemical binding]; other site 264198010695 Mg2+ binding site [ion binding]; other site 264198010696 G-X-G motif; other site 264198010697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198010698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198010699 dimer interface [polypeptide binding]; other site 264198010700 phosphorylation site [posttranslational modification] 264198010701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010702 ATP binding site [chemical binding]; other site 264198010703 Mg2+ binding site [ion binding]; other site 264198010704 G-X-G motif; other site 264198010705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010706 S-adenosylmethionine binding site [chemical binding]; other site 264198010707 Uncharacterized conserved protein [Function unknown]; Region: COG2353 264198010708 Uncharacterized conserved protein [Function unknown]; Region: COG2353 264198010709 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 264198010710 adenylosuccinate lyase; Provisional; Region: PRK09285 264198010711 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 264198010712 tetramer interface [polypeptide binding]; other site 264198010713 active site 264198010714 putative glutathione S-transferase; Provisional; Region: PRK10357 264198010715 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 264198010716 putative C-terminal domain interface [polypeptide binding]; other site 264198010717 putative GSH binding site (G-site) [chemical binding]; other site 264198010718 putative dimer interface [polypeptide binding]; other site 264198010719 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 264198010720 dimer interface [polypeptide binding]; other site 264198010721 N-terminal domain interface [polypeptide binding]; other site 264198010722 putative substrate binding pocket (H-site) [chemical binding]; other site 264198010723 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 264198010724 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264198010725 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 264198010726 nudix motif; other site 264198010727 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198010728 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198010729 ligand binding site [chemical binding]; other site 264198010730 homodimer interface [polypeptide binding]; other site 264198010731 NAD(P) binding site [chemical binding]; other site 264198010732 trimer interface B [polypeptide binding]; other site 264198010733 trimer interface A [polypeptide binding]; other site 264198010734 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 264198010735 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264198010736 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 264198010737 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198010738 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198010739 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198010740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010741 active site 264198010742 phosphorylation site [posttranslational modification] 264198010743 intermolecular recognition site; other site 264198010744 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 264198010745 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 264198010746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264198010747 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198010748 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198010749 putative catalytic residue [active] 264198010750 Predicted membrane protein [Function unknown]; Region: COG1981 264198010751 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 264198010752 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 264198010753 putative catalytic cysteine [active] 264198010754 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 264198010755 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264198010756 Lipopolysaccharide-assembly; Region: LptE; cl01125 264198010757 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264198010758 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264198010759 HIGH motif; other site 264198010760 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264198010761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198010762 active site 264198010763 KMSKS motif; other site 264198010764 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264198010765 tRNA binding surface [nucleotide binding]; other site 264198010766 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264198010767 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264198010768 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264198010769 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 264198010770 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 264198010771 ferric uptake regulator; Provisional; Region: fur; PRK09462 264198010772 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264198010773 metal binding site 2 [ion binding]; metal-binding site 264198010774 putative DNA binding helix; other site 264198010775 metal binding site 1 [ion binding]; metal-binding site 264198010776 dimer interface [polypeptide binding]; other site 264198010777 structural Zn2+ binding site [ion binding]; other site 264198010778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198010779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198010781 dimerization interface [polypeptide binding]; other site 264198010782 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 264198010783 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 264198010784 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 264198010785 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264198010786 transketolase; Reviewed; Region: PRK12753 264198010787 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264198010788 TPP-binding site [chemical binding]; other site 264198010789 dimer interface [polypeptide binding]; other site 264198010790 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264198010791 PYR/PP interface [polypeptide binding]; other site 264198010792 dimer interface [polypeptide binding]; other site 264198010793 TPP binding site [chemical binding]; other site 264198010794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198010795 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 264198010796 putative dimer interface [polypeptide binding]; other site 264198010797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198010798 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 264198010799 RNA methyltransferase, RsmE family; Region: TIGR00046 264198010800 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 264198010801 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 264198010802 putative RNAase interaction site [polypeptide binding]; other site 264198010803 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 264198010804 active site 264198010805 barstar interaction site; other site 264198010806 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 264198010807 malic enzyme; Reviewed; Region: PRK12862 264198010808 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264198010809 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264198010810 putative NAD(P) binding site [chemical binding]; other site 264198010811 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264198010812 thiamine monophosphate kinase; Provisional; Region: PRK05731 264198010813 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 264198010814 ATP binding site [chemical binding]; other site 264198010815 dimerization interface [polypeptide binding]; other site 264198010816 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198010817 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 264198010818 tetramer interfaces [polypeptide binding]; other site 264198010819 beta-alpha-beta structure motif; other site 264198010820 binuclear metal-binding site [ion binding]; other site 264198010821 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 264198010822 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 264198010823 active site 264198010824 dimer interface [polypeptide binding]; other site 264198010825 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 264198010826 EamA-like transporter family; Region: EamA; pfam00892 264198010827 EamA-like transporter family; Region: EamA; pfam00892 264198010828 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264198010829 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 264198010830 Cl binding site [ion binding]; other site 264198010831 oligomer interface [polypeptide binding]; other site 264198010832 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 264198010833 Transglycosylase; Region: Transgly; cl17702 264198010834 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264198010835 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264198010836 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264198010837 shikimate binding site; other site 264198010838 NAD(P) binding site [chemical binding]; other site 264198010839 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264198010840 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 264198010841 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 264198010842 RNB domain; Region: RNB; pfam00773 264198010843 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264198010844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010845 NAD(P) binding site [chemical binding]; other site 264198010846 active site 264198010847 Chorismate lyase; Region: Chor_lyase; cl01230 264198010848 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 264198010849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198010850 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 264198010851 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264198010852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198010853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198010854 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264198010855 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198010856 catalytic residues [active] 264198010857 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264198010858 Dehydroquinase class II; Region: DHquinase_II; pfam01220 264198010859 trimer interface [polypeptide binding]; other site 264198010860 active site 264198010861 dimer interface [polypeptide binding]; other site 264198010862 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 264198010863 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198010864 carboxyltransferase (CT) interaction site; other site 264198010865 biotinylation site [posttranslational modification]; other site 264198010866 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198010867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198010868 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198010869 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198010870 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 264198010871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010872 S-adenosylmethionine binding site [chemical binding]; other site 264198010873 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 264198010874 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 264198010875 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 264198010876 dimer interface [polypeptide binding]; other site 264198010877 catalytic triad [active] 264198010878 peroxidatic and resolving cysteines [active] 264198010879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198010880 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 264198010881 substrate binding site [chemical binding]; other site 264198010882 ATP binding site [chemical binding]; other site 264198010883 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 264198010884 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 264198010885 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198010886 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 264198010887 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198010888 N-terminal plug; other site 264198010889 ligand-binding site [chemical binding]; other site 264198010890 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 264198010891 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 264198010892 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198010893 N-terminal plug; other site 264198010894 ligand-binding site [chemical binding]; other site 264198010895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198010896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010897 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 264198010898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198010899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198010900 active site 264198010901 catalytic tetrad [active] 264198010902 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 264198010903 recombination associated protein; Reviewed; Region: rdgC; PRK00321 264198010904 Transmembrane secretion effector; Region: MFS_3; pfam05977 264198010905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198010906 putative substrate translocation pore; other site 264198010907 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198010908 active site 264198010909 Oxygen tolerance; Region: BatD; pfam13584 264198010910 von Willebrand factor type A domain; Region: VWA_2; pfam13519 264198010911 metal ion-dependent adhesion site (MIDAS); other site 264198010912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198010913 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264198010914 TPR motif; other site 264198010915 binding surface 264198010916 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 264198010917 metal ion-dependent adhesion site (MIDAS); other site 264198010918 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 264198010919 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264198010920 Protein of unknown function DUF58; Region: DUF58; pfam01882 264198010921 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198010922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010923 Walker A motif; other site 264198010924 ATP binding site [chemical binding]; other site 264198010925 Walker B motif; other site 264198010926 arginine finger; other site 264198010927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264198010928 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264198010929 Sulfatase; Region: Sulfatase; pfam00884 264198010930 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 264198010931 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264198010932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198010933 motif II; other site 264198010934 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264198010935 Uncharacterized conserved protein [Function unknown]; Region: COG1262 264198010936 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 264198010937 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 264198010938 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264198010939 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264198010940 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198010941 dinuclear metal binding motif [ion binding]; other site 264198010942 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 264198010943 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 264198010944 DNA binding residues [nucleotide binding] 264198010945 putative dimer interface [polypeptide binding]; other site 264198010946 putative metal binding residues [ion binding]; other site 264198010947 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 264198010948 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264198010949 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198010950 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 264198010951 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 264198010952 enoyl-CoA hydratase; Provisional; Region: PRK06144 264198010953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198010954 substrate binding site [chemical binding]; other site 264198010955 oxyanion hole (OAH) forming residues; other site 264198010956 trimer interface [polypeptide binding]; other site 264198010957 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198010958 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198010959 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198010960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198010961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198010963 dimerization interface [polypeptide binding]; other site 264198010964 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264198010965 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264198010966 active site 264198010967 metal binding site [ion binding]; metal-binding site 264198010968 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 264198010969 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198010970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198010971 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198010972 dimerization interface [polypeptide binding]; other site 264198010973 substrate binding pocket [chemical binding]; other site 264198010974 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 264198010975 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 264198010976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198010977 catalytic residue [active] 264198010978 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 264198010979 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 264198010980 Pyocin large subunit [General function prediction only]; Region: COG5529 264198010981 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 264198010982 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 264198010983 putative RNAase interaction site [polypeptide binding]; other site 264198010984 ribonuclease; Region: Ribonuclease; pfam00545 264198010985 active site 264198010986 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 264198010987 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 264198010988 haemagglutination activity domain; Region: Haemagg_act; pfam05860 264198010989 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 264198010990 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 264198010991 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 264198010992 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 264198010993 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 264198010994 haemagglutination activity domain; Region: Haemagg_act; pfam05860 264198010995 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 264198010996 OmpA family; Region: OmpA; pfam00691 264198010997 ligand binding site [chemical binding]; other site 264198010998 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 264198010999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198011000 Zn2+ binding site [ion binding]; other site 264198011001 Mg2+ binding site [ion binding]; other site 264198011002 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264198011003 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 264198011004 dimer interface [polypeptide binding]; other site 264198011005 putative radical transfer pathway; other site 264198011006 diiron center [ion binding]; other site 264198011007 tyrosyl radical; other site 264198011008 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 264198011009 ATP cone domain; Region: ATP-cone; pfam03477 264198011010 Class I ribonucleotide reductase; Region: RNR_I; cd01679 264198011011 active site 264198011012 dimer interface [polypeptide binding]; other site 264198011013 catalytic residues [active] 264198011014 effector binding site; other site 264198011015 R2 peptide binding site; other site 264198011016 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 264198011017 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264198011018 amidase catalytic site [active] 264198011019 Zn binding residues [ion binding]; other site 264198011020 substrate binding site [chemical binding]; other site 264198011021 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198011022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198011023 active site 264198011024 phosphorylation site [posttranslational modification] 264198011025 intermolecular recognition site; other site 264198011026 dimerization interface [polypeptide binding]; other site 264198011027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198011028 Walker A motif; other site 264198011029 ATP binding site [chemical binding]; other site 264198011030 Walker B motif; other site 264198011031 arginine finger; other site 264198011032 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198011033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198011034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198011035 dimer interface [polypeptide binding]; other site 264198011036 phosphorylation site [posttranslational modification] 264198011037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198011038 ATP binding site [chemical binding]; other site 264198011039 Mg2+ binding site [ion binding]; other site 264198011040 G-X-G motif; other site 264198011041 FHIPEP family; Region: FHIPEP; pfam00771 264198011042 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264198011043 signal recognition particle protein; Provisional; Region: PRK10867 264198011044 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 264198011045 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264198011046 P loop; other site 264198011047 GTP binding site [chemical binding]; other site 264198011048 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264198011049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198011050 active site 264198011051 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264198011052 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 264198011053 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 264198011054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 264198011055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198011056 catalytic residue [active] 264198011057 prolyl-tRNA synthetase; Provisional; Region: PRK09194 264198011058 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 264198011059 dimer interface [polypeptide binding]; other site 264198011060 motif 1; other site 264198011061 active site 264198011062 motif 2; other site 264198011063 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 264198011064 putative deacylase active site [active] 264198011065 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264198011066 active site 264198011067 motif 3; other site 264198011068 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 264198011069 anticodon binding site; other site 264198011070 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 264198011071 putative active site [active] 264198011072 Ap4A binding site [chemical binding]; other site 264198011073 nudix motif; other site 264198011074 putative metal binding site [ion binding]; other site 264198011075 CNP1-like family; Region: CNP1; pfam08750 264198011076 gamma-glutamyl kinase; Provisional; Region: PRK05429 264198011077 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 264198011078 nucleotide binding site [chemical binding]; other site 264198011079 homotetrameric interface [polypeptide binding]; other site 264198011080 putative phosphate binding site [ion binding]; other site 264198011081 putative allosteric binding site; other site 264198011082 PUA domain; Region: PUA; pfam01472 264198011083 GTPase CgtA; Reviewed; Region: obgE; PRK12299 264198011084 GTP1/OBG; Region: GTP1_OBG; pfam01018 264198011085 Obg GTPase; Region: Obg; cd01898 264198011086 G1 box; other site 264198011087 GTP/Mg2+ binding site [chemical binding]; other site 264198011088 Switch I region; other site 264198011089 G2 box; other site 264198011090 G3 box; other site 264198011091 Switch II region; other site 264198011092 G4 box; other site 264198011093 G5 box; other site 264198011094 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 264198011095 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 264198011096 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 264198011097 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264198011098 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264198011099 substrate binding pocket [chemical binding]; other site 264198011100 chain length determination region; other site 264198011101 substrate-Mg2+ binding site; other site 264198011102 catalytic residues [active] 264198011103 aspartate-rich region 1; other site 264198011104 active site lid residues [active] 264198011105 aspartate-rich region 2; other site 264198011106 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 264198011107 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264198011108 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264198011109 Walker A motif; other site 264198011110 ATP binding site [chemical binding]; other site 264198011111 Walker B motif; other site 264198011112 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264198011113 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198011114 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198011115 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 264198011116 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 264198011117 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 264198011118 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264198011119 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264198011120 CoA-binding site [chemical binding]; other site 264198011121 ATP-binding [chemical binding]; other site 264198011122 hypothetical protein; Provisional; Region: PRK05287 264198011123 Domain of unknown function (DUF329); Region: DUF329; pfam03884 264198011124 Predicted membrane protein [Function unknown]; Region: COG1297 264198011125 putative oligopeptide transporter, OPT family; Region: TIGR00733 264198011126 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264198011127 active site 264198011128 8-oxo-dGMP binding site [chemical binding]; other site 264198011129 nudix motif; other site 264198011130 metal binding site [ion binding]; metal-binding site 264198011131 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 264198011132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198011133 Walker A motif; other site 264198011134 ATP binding site [chemical binding]; other site 264198011135 Walker B motif; other site 264198011136 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 264198011137 heterotetramer interface [polypeptide binding]; other site 264198011138 active site pocket [active] 264198011139 cleavage site 264198011140 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 264198011141 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 264198011142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 264198011143 nucleotide binding region [chemical binding]; other site 264198011144 ATP-binding site [chemical binding]; other site 264198011145 SEC-C motif; Region: SEC-C; pfam02810 264198011146 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 264198011147 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 264198011148 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 264198011149 catalytic triad [active] 264198011150 dimer interface [polypeptide binding]; other site 264198011151 cell division protein FtsZ; Validated; Region: PRK09330 264198011152 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264198011153 nucleotide binding site [chemical binding]; other site 264198011154 SulA interaction site; other site 264198011155 cell division protein FtsA; Region: ftsA; TIGR01174 264198011156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264198011157 nucleotide binding site [chemical binding]; other site 264198011158 Cell division protein FtsA; Region: FtsA; pfam14450 264198011159 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264198011160 Cell division protein FtsQ; Region: FtsQ; pfam03799 264198011161 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 264198011162 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264198011163 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198011164 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264198011165 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264198011166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198011167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198011168 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264198011169 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264198011170 active site 264198011171 homodimer interface [polypeptide binding]; other site 264198011172 cell division protein FtsW; Region: ftsW; TIGR02614 264198011173 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 264198011174 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198011175 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198011176 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264198011177 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264198011178 Mg++ binding site [ion binding]; other site 264198011179 putative catalytic motif [active] 264198011180 putative substrate binding site [chemical binding]; other site 264198011181 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 264198011182 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264198011183 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198011184 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198011185 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264198011186 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198011187 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198011188 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264198011189 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264198011190 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264198011191 Cell division protein FtsL; Region: FtsL; cl11433 264198011192 MraW methylase family; Region: Methyltransf_5; cl17771 264198011193 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 264198011194 cell division protein MraZ; Reviewed; Region: PRK00326 264198011195 MraZ protein; Region: MraZ; pfam02381 264198011196 MraZ protein; Region: MraZ; pfam02381 264198011197 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 264198011198 diiron binding motif [ion binding]; other site 264198011199 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198011200 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198011201 trimer interface [polypeptide binding]; other site 264198011202 eyelet of channel; other site 264198011203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198011204 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198011205 MarR family; Region: MarR; pfam01047 264198011206 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 264198011207 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 264198011208 acyl-activating enzyme (AAE) consensus motif; other site 264198011209 putative AMP binding site [chemical binding]; other site 264198011210 putative active site [active] 264198011211 putative CoA binding site [chemical binding]; other site 264198011212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198011213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198011214 acyl-CoA synthetase; Validated; Region: PRK06178 264198011215 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198011216 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 264198011217 acyl-activating enzyme (AAE) consensus motif; other site 264198011218 putative AMP binding site [chemical binding]; other site 264198011219 putative active site [active] 264198011220 putative CoA binding site [chemical binding]; other site 264198011221 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198011222 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198011223 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198011224 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198011225 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 264198011226 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198011227 carboxyltransferase (CT) interaction site; other site 264198011228 biotinylation site [posttranslational modification]; other site 264198011229 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264198011230 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264198011231 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264198011232 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198011233 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198011234 putative ligand binding site [chemical binding]; other site 264198011235 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 264198011236 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198011237 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 264198011238 putative [4Fe-4S] binding site [ion binding]; other site 264198011239 putative molybdopterin cofactor binding site [chemical binding]; other site 264198011240 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 264198011241 putative molybdopterin cofactor binding site; other site 264198011242 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198011243 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 264198011244 putative ligand binding site [chemical binding]; other site 264198011245 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 264198011246 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198011247 Walker A/P-loop; other site 264198011248 ATP binding site [chemical binding]; other site 264198011249 Q-loop/lid; other site 264198011250 ABC transporter signature motif; other site 264198011251 Walker B; other site 264198011252 D-loop; other site 264198011253 H-loop/switch region; other site 264198011254 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264198011255 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264198011256 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198011257 Walker A/P-loop; other site 264198011258 ATP binding site [chemical binding]; other site 264198011259 Q-loop/lid; other site 264198011260 ABC transporter signature motif; other site 264198011261 Walker B; other site 264198011262 D-loop; other site 264198011263 H-loop/switch region; other site 264198011264 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198011265 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264198011266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198011267 putative PBP binding loops; other site 264198011268 dimer interface [polypeptide binding]; other site 264198011269 ABC-ATPase subunit interface; other site 264198011270 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264198011271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198011272 dimer interface [polypeptide binding]; other site 264198011273 conserved gate region; other site 264198011274 putative PBP binding loops; other site 264198011275 ABC-ATPase subunit interface; other site 264198011276 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264198011277 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264198011278 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198011279 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198011280 metal binding site [ion binding]; metal-binding site 264198011281 putative dimer interface [polypeptide binding]; other site 264198011282 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 264198011283 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 264198011284 enoyl-CoA hydratase; Provisional; Region: PRK05862 264198011285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198011286 substrate binding site [chemical binding]; other site 264198011287 oxyanion hole (OAH) forming residues; other site 264198011288 trimer interface [polypeptide binding]; other site 264198011289 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198011290 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198011291 putative active site [active] 264198011292 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198011293 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264198011294 Walker A/P-loop; other site 264198011295 ATP binding site [chemical binding]; other site 264198011296 Q-loop/lid; other site 264198011297 ABC transporter signature motif; other site 264198011298 Walker B; other site 264198011299 D-loop; other site 264198011300 H-loop/switch region; other site 264198011301 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198011302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198011303 dimer interface [polypeptide binding]; other site 264198011304 conserved gate region; other site 264198011305 putative PBP binding loops; other site 264198011306 ABC-ATPase subunit interface; other site 264198011307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198011308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198011309 substrate binding pocket [chemical binding]; other site 264198011310 membrane-bound complex binding site; other site 264198011311 hinge residues; other site 264198011312 enoyl-CoA hydratase; Provisional; Region: PRK08140 264198011313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198011314 substrate binding site [chemical binding]; other site 264198011315 oxyanion hole (OAH) forming residues; other site 264198011316 trimer interface [polypeptide binding]; other site 264198011317 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198011318 CoenzymeA binding site [chemical binding]; other site 264198011319 subunit interaction site [polypeptide binding]; other site 264198011320 PHB binding site; other site 264198011321 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 264198011322 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 264198011323 active site 264198011324 AMP binding site [chemical binding]; other site 264198011325 homodimer interface [polypeptide binding]; other site 264198011326 acyl-activating enzyme (AAE) consensus motif; other site 264198011327 CoA binding site [chemical binding]; other site 264198011328 MltA specific insert domain; Region: MltA; smart00925 264198011329 3D domain; Region: 3D; pfam06725 264198011330 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 264198011331 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264198011332 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 264198011333 substrate binding site [chemical binding]; other site 264198011334 hexamer interface [polypeptide binding]; other site 264198011335 metal binding site [ion binding]; metal-binding site 264198011336 phosphoglycolate phosphatase; Provisional; Region: PRK13222 264198011337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198011338 motif II; other site 264198011339 anthranilate synthase component I; Provisional; Region: PRK13565 264198011340 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264198011341 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264198011342 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 264198011343 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264198011344 glutamine binding [chemical binding]; other site 264198011345 catalytic triad [active] 264198011346 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 264198011347 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264198011348 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264198011349 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 264198011350 active site 264198011351 ribulose/triose binding site [chemical binding]; other site 264198011352 phosphate binding site [ion binding]; other site 264198011353 substrate (anthranilate) binding pocket [chemical binding]; other site 264198011354 product (indole) binding pocket [chemical binding]; other site 264198011355 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 264198011356 putative active site [active] 264198011357 putative metal binding residues [ion binding]; other site 264198011358 signature motif; other site 264198011359 putative triphosphate binding site [ion binding]; other site 264198011360 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264198011361 ligand binding site [chemical binding]; other site 264198011362 active site 264198011363 UGI interface [polypeptide binding]; other site 264198011364 catalytic site [active] 264198011365 acylphosphatase; Provisional; Region: PRK14430 264198011366 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 264198011367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198011368 dimer interface [polypeptide binding]; other site 264198011369 conserved gate region; other site 264198011370 putative PBP binding loops; other site 264198011371 ABC-ATPase subunit interface; other site 264198011372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198011373 dimer interface [polypeptide binding]; other site 264198011374 conserved gate region; other site 264198011375 putative PBP binding loops; other site 264198011376 ABC-ATPase subunit interface; other site 264198011377 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198011378 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198011379 Walker A/P-loop; other site 264198011380 ATP binding site [chemical binding]; other site 264198011381 Q-loop/lid; other site 264198011382 ABC transporter signature motif; other site 264198011383 Walker B; other site 264198011384 D-loop; other site 264198011385 H-loop/switch region; other site 264198011386 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 264198011387 Predicted membrane protein [Function unknown]; Region: COG1289 264198011388 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 264198011389 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264198011390 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 264198011391 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 264198011392 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264198011393 protein binding site [polypeptide binding]; other site 264198011394 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 264198011395 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 264198011396 NADP binding site [chemical binding]; other site 264198011397 dimer interface [polypeptide binding]; other site 264198011398 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 264198011399 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 264198011400 dimerization domain [polypeptide binding]; other site 264198011401 dimer interface [polypeptide binding]; other site 264198011402 catalytic residues [active] 264198011403 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 264198011404 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 264198011405 GTP-binding protein YchF; Reviewed; Region: PRK09601 264198011406 YchF GTPase; Region: YchF; cd01900 264198011407 G1 box; other site 264198011408 GTP/Mg2+ binding site [chemical binding]; other site 264198011409 Switch I region; other site 264198011410 G2 box; other site 264198011411 Switch II region; other site 264198011412 G3 box; other site 264198011413 G4 box; other site 264198011414 G5 box; other site 264198011415 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264198011416 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 264198011417 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 264198011418 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 264198011419 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 264198011420 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 264198011421 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 264198011422 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 264198011423 tRNA; other site 264198011424 putative tRNA binding site [nucleotide binding]; other site 264198011425 putative NADP binding site [chemical binding]; other site 264198011426 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 264198011427 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264198011428 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264198011429 RF-1 domain; Region: RF-1; pfam00472 264198011430 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 264198011431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198011432 S-adenosylmethionine binding site [chemical binding]; other site 264198011433 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 264198011434 putative GSH binding site [chemical binding]; other site 264198011435 catalytic residues [active] 264198011436 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 264198011437 Flavoprotein; Region: Flavoprotein; pfam02441 264198011438 aldehyde dehydrogenase family 7 member; Region: PLN02315 264198011439 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264198011440 NAD(P) binding site [chemical binding]; other site 264198011441 catalytic residues [active] 264198011442 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 264198011443 TrkA-N domain; Region: TrkA_N; pfam02254 264198011444 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198011445 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 264198011446 AsnC family; Region: AsnC_trans_reg; pfam01037 264198011447 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264198011448 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264198011449 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264198011450 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 264198011451 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 264198011452 putative ion selectivity filter; other site 264198011453 putative pore gating glutamate residue; other site 264198011454 putative H+/Cl- coupling transport residue; other site 264198011455 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198011456 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 264198011457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198011458 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198011459 acyl-activating enzyme (AAE) consensus motif; other site 264198011460 putative AMP binding site [chemical binding]; other site 264198011461 putative active site [active] 264198011462 acyl-activating enzyme (AAE) consensus motif; other site 264198011463 putative CoA binding site [chemical binding]; other site 264198011464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198011465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198011466 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198011467 putative effector binding pocket; other site 264198011468 dimerization interface [polypeptide binding]; other site 264198011469 Predicted transcriptional regulators [Transcription]; Region: COG1733 264198011470 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264198011471 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264198011472 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 264198011473 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198011474 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198011475 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198011476 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198011477 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198011478 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264198011479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198011480 putative active site [active] 264198011481 putative metal binding site [ion binding]; other site 264198011482 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 264198011483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198011484 Walker A/P-loop; other site 264198011485 ATP binding site [chemical binding]; other site 264198011486 Q-loop/lid; other site 264198011487 ABC transporter signature motif; other site 264198011488 Walker B; other site 264198011489 D-loop; other site 264198011490 H-loop/switch region; other site 264198011491 ABC transporter; Region: ABC_tran_2; pfam12848 264198011492 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264198011493 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 264198011494 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 264198011495 active site 264198011496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 264198011497 active site 264198011498 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 264198011499 xanthine permease; Region: pbuX; TIGR03173 264198011500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198011501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198011502 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198011503 putative dimerization interface [polypeptide binding]; other site 264198011504 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198011505 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 264198011506 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 264198011507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198011508 catalytic loop [active] 264198011509 iron binding site [ion binding]; other site 264198011510 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198011511 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 264198011512 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198011513 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198011514 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 264198011515 Flavoprotein; Region: Flavoprotein; pfam02441 264198011516 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198011517 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 264198011518 P-loop, Walker A motif; other site 264198011519 Base recognition motif; other site 264198011520 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 264198011521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198011522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198011523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198011524 xanthine permease; Region: pbuX; TIGR03173 264198011525 amidohydrolase; Provisional; Region: PRK12393 264198011526 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264198011527 active site 264198011528 putative substrate binding pocket [chemical binding]; other site 264198011529 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198011530 Cytochrome c; Region: Cytochrom_C; cl11414 264198011531 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 264198011532 sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It; Region: bact_SorA_Moco; cd02114 264198011533 Moco binding site; other site 264198011534 metal coordination site [ion binding]; other site 264198011535 putative dimerization interface [polypeptide binding]; other site 264198011536 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264198011537 active site lid residues [active] 264198011538 substrate binding pocket [chemical binding]; other site 264198011539 catalytic residues [active] 264198011540 substrate-Mg2+ binding site; other site 264198011541 aspartate-rich region 1; other site 264198011542 aspartate-rich region 2; other site 264198011543 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198011544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198011545 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198011546 putative dimerization interface [polypeptide binding]; other site 264198011547 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198011548 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198011549 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198011550 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198011551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198011552 substrate binding site [chemical binding]; other site 264198011553 oxyanion hole (OAH) forming residues; other site 264198011554 trimer interface [polypeptide binding]; other site 264198011555 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 264198011556 stringent starvation protein A; Provisional; Region: sspA; PRK09481 264198011557 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 264198011558 C-terminal domain interface [polypeptide binding]; other site 264198011559 putative GSH binding site (G-site) [chemical binding]; other site 264198011560 dimer interface [polypeptide binding]; other site 264198011561 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 264198011562 dimer interface [polypeptide binding]; other site 264198011563 N-terminal domain interface [polypeptide binding]; other site 264198011564 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 264198011565 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 264198011566 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 264198011567 Qi binding site; other site 264198011568 intrachain domain interface; other site 264198011569 interchain domain interface [polypeptide binding]; other site 264198011570 heme bH binding site [chemical binding]; other site 264198011571 heme bL binding site [chemical binding]; other site 264198011572 Qo binding site; other site 264198011573 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 264198011574 interchain domain interface [polypeptide binding]; other site 264198011575 intrachain domain interface; other site 264198011576 Qi binding site; other site 264198011577 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 264198011578 Qo binding site; other site 264198011579 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 264198011580 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 264198011581 [2Fe-2S] cluster binding site [ion binding]; other site 264198011582 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 264198011583 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 264198011584 Uncharacterized conserved protein [Function unknown]; Region: COG0327 264198011585 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 264198011586 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264198011587 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198011588 protein binding site [polypeptide binding]; other site 264198011589 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198011590 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198011591 trimer interface [polypeptide binding]; other site 264198011592 eyelet of channel; other site 264198011593 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 264198011594 sec-independent translocase; Provisional; Region: tatB; PRK01919 264198011595 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 264198011596 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 264198011597 nucleotide binding site/active site [active] 264198011598 HIT family signature motif; other site 264198011599 catalytic residue [active] 264198011600 Predicted membrane protein [Function unknown]; Region: COG3671 264198011601 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 264198011602 metal binding site [ion binding]; metal-binding site 264198011603 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 264198011604 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 264198011605 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 264198011606 substrate binding site [chemical binding]; other site 264198011607 glutamase interaction surface [polypeptide binding]; other site 264198011608 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 264198011609 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 264198011610 catalytic residues [active] 264198011611 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 264198011612 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 264198011613 putative active site [active] 264198011614 oxyanion strand; other site 264198011615 catalytic triad [active] 264198011616 MarC family integral membrane protein; Region: MarC; cl00919 264198011617 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 264198011618 putative active site pocket [active] 264198011619 4-fold oligomerization interface [polypeptide binding]; other site 264198011620 metal binding residues [ion binding]; metal-binding site 264198011621 3-fold/trimer interface [polypeptide binding]; other site 264198011622 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 264198011623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198011624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198011625 homodimer interface [polypeptide binding]; other site 264198011626 catalytic residue [active] 264198011627 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 264198011628 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264198011629 NAD binding site [chemical binding]; other site 264198011630 dimerization interface [polypeptide binding]; other site 264198011631 product binding site; other site 264198011632 substrate binding site [chemical binding]; other site 264198011633 zinc binding site [ion binding]; other site 264198011634 catalytic residues [active] 264198011635 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 264198011636 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 264198011637 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 264198011638 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264198011639 hinge; other site 264198011640 active site 264198011641 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 264198011642 ABC-2 type transporter; Region: ABC2_membrane; cl17235 264198011643 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264198011644 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264198011645 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 264198011646 Walker A/P-loop; other site 264198011647 ATP binding site [chemical binding]; other site 264198011648 Q-loop/lid; other site 264198011649 ABC transporter signature motif; other site 264198011650 Walker B; other site 264198011651 D-loop; other site 264198011652 H-loop/switch region; other site 264198011653 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 264198011654 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 264198011655 VacJ like lipoprotein; Region: VacJ; cl01073 264198011656 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 264198011657 mce related protein; Region: MCE; pfam02470 264198011658 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264198011659 Permease; Region: Permease; pfam02405 264198011660 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264198011661 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264198011662 Walker A/P-loop; other site 264198011663 ATP binding site [chemical binding]; other site 264198011664 Q-loop/lid; other site 264198011665 ABC transporter signature motif; other site 264198011666 Walker B; other site 264198011667 D-loop; other site 264198011668 H-loop/switch region; other site 264198011669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198011670 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264198011671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198011672 Coenzyme A binding pocket [chemical binding]; other site 264198011673 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 264198011674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198011675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198011676 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 264198011677 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 264198011678 active site 264198011679 dimer interface [polypeptide binding]; other site 264198011680 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 264198011681 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264198011682 active site 264198011683 FMN binding site [chemical binding]; other site 264198011684 substrate binding site [chemical binding]; other site 264198011685 3Fe-4S cluster binding site [ion binding]; other site 264198011686 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 264198011687 domain interface; other site 264198011688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 264198011689 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 264198011690 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198011691 Zn2+ binding site [ion binding]; other site 264198011692 Mg2+ binding site [ion binding]; other site 264198011693 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264198011694 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264198011695 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 264198011696 active site 264198011697 dimer interface [polypeptide binding]; other site 264198011698 metal binding site [ion binding]; metal-binding site 264198011699 shikimate kinase; Reviewed; Region: aroK; PRK00131 264198011700 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264198011701 ADP binding site [chemical binding]; other site 264198011702 magnesium binding site [ion binding]; other site 264198011703 putative shikimate binding site; other site 264198011704 AMIN domain; Region: AMIN; pfam11741 264198011705 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 264198011706 Secretin and TonB N terminus short domain; Region: STN; smart00965 264198011707 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198011708 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198011709 Pilus assembly protein, PilP; Region: PilP; pfam04351 264198011710 Pilus assembly protein, PilO; Region: PilO; cl01234 264198011711 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 264198011712 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 264198011713 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 264198011714 Cell division protein FtsA; Region: FtsA; cl17206 264198011715 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 264198011716 Transglycosylase; Region: Transgly; pfam00912 264198011717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264198011718 frataxin-like protein; Provisional; Region: cyaY; PRK00446 264198011719 putative iron binding site [ion binding]; other site 264198011720 diaminopimelate decarboxylase; Region: lysA; TIGR01048 264198011721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264198011722 active site 264198011723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198011724 substrate binding site [chemical binding]; other site 264198011725 catalytic residues [active] 264198011726 dimer interface [polypeptide binding]; other site 264198011727 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 264198011728 TMAO/DMSO reductase; Reviewed; Region: PRK05363 264198011729 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 264198011730 Moco binding site; other site 264198011731 metal coordination site [ion binding]; other site 264198011732 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198011733 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264198011734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198011735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198011736 DNA binding residues [nucleotide binding] 264198011737 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 264198011738 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 264198011739 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 264198011740 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 264198011741 ResB-like family; Region: ResB; pfam05140 264198011742 Cytochrome c; Region: Cytochrom_C; cl11414 264198011743 Cytochrome c; Region: Cytochrom_C; cl11414 264198011744 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 264198011745 G1 box; other site 264198011746 GTP/Mg2+ binding site [chemical binding]; other site 264198011747 Switch I region; other site 264198011748 G2 box; other site 264198011749 G3 box; other site 264198011750 Switch II region; other site 264198011751 G4 box; other site 264198011752 G5 box; other site 264198011753 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 264198011754 dimer interface [polypeptide binding]; other site 264198011755 active site 264198011756 aspartate-rich active site metal binding site; other site 264198011757 allosteric magnesium binding site [ion binding]; other site 264198011758 Schiff base residues; other site 264198011759 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 264198011760 oligomer interface [polypeptide binding]; other site 264198011761 metal binding site [ion binding]; metal-binding site 264198011762 metal binding site [ion binding]; metal-binding site 264198011763 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264198011764 putative Cl binding site [ion binding]; other site 264198011765 aspartate ring; other site 264198011766 hydrophobic gate; other site 264198011767 periplasmic entrance; other site 264198011768 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 264198011769 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 264198011770 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 264198011771 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198011772 DsbD alpha interface [polypeptide binding]; other site 264198011773 catalytic residues [active] 264198011774 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 264198011775 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 264198011776 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264198011777 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264198011778 alphaNTD homodimer interface [polypeptide binding]; other site 264198011779 alphaNTD - beta interaction site [polypeptide binding]; other site 264198011780 alphaNTD - beta' interaction site [polypeptide binding]; other site 264198011781 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 264198011782 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264198011783 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264198011784 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198011785 RNA binding surface [nucleotide binding]; other site 264198011786 30S ribosomal protein S11; Validated; Region: PRK05309 264198011787 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264198011788 30S ribosomal protein S13; Region: bact_S13; TIGR03631 264198011789 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 264198011790 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264198011791 SecY translocase; Region: SecY; pfam00344 264198011792 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 264198011793 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264198011794 23S rRNA binding site [nucleotide binding]; other site 264198011795 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264198011796 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264198011797 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264198011798 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264198011799 5S rRNA interface [nucleotide binding]; other site 264198011800 L27 interface [polypeptide binding]; other site 264198011801 23S rRNA interface [nucleotide binding]; other site 264198011802 L5 interface [polypeptide binding]; other site 264198011803 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264198011804 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264198011805 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264198011806 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 264198011807 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 264198011808 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264198011809 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264198011810 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264198011811 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 264198011812 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 264198011813 RNA binding site [nucleotide binding]; other site 264198011814 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 264198011815 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 264198011816 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264198011817 23S rRNA interface [nucleotide binding]; other site 264198011818 putative translocon interaction site; other site 264198011819 signal recognition particle (SRP54) interaction site; other site 264198011820 L23 interface [polypeptide binding]; other site 264198011821 trigger factor interaction site; other site 264198011822 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264198011823 23S rRNA interface [nucleotide binding]; other site 264198011824 5S rRNA interface [nucleotide binding]; other site 264198011825 putative antibiotic binding site [chemical binding]; other site 264198011826 L25 interface [polypeptide binding]; other site 264198011827 L27 interface [polypeptide binding]; other site 264198011828 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264198011829 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264198011830 G-X-X-G motif; other site 264198011831 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264198011832 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264198011833 putative translocon binding site; other site 264198011834 protein-rRNA interface [nucleotide binding]; other site 264198011835 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 264198011836 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264198011837 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264198011838 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264198011839 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 264198011840 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 264198011841 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 264198011842 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198011843 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198011844 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 264198011845 elongation factor Tu; Reviewed; Region: PRK00049 264198011846 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264198011847 G1 box; other site 264198011848 GEF interaction site [polypeptide binding]; other site 264198011849 GTP/Mg2+ binding site [chemical binding]; other site 264198011850 Switch I region; other site 264198011851 G2 box; other site 264198011852 G3 box; other site 264198011853 Switch II region; other site 264198011854 G4 box; other site 264198011855 G5 box; other site 264198011856 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264198011857 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264198011858 Antibiotic Binding Site [chemical binding]; other site 264198011859 elongation factor G; Reviewed; Region: PRK00007 264198011860 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264198011861 G1 box; other site 264198011862 putative GEF interaction site [polypeptide binding]; other site 264198011863 GTP/Mg2+ binding site [chemical binding]; other site 264198011864 Switch I region; other site 264198011865 G2 box; other site 264198011866 G3 box; other site 264198011867 Switch II region; other site 264198011868 G4 box; other site 264198011869 G5 box; other site 264198011870 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264198011871 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264198011872 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264198011873 30S ribosomal protein S7; Validated; Region: PRK05302 264198011874 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264198011875 S17 interaction site [polypeptide binding]; other site 264198011876 S8 interaction site; other site 264198011877 16S rRNA interaction site [nucleotide binding]; other site 264198011878 streptomycin interaction site [chemical binding]; other site 264198011879 23S rRNA interaction site [nucleotide binding]; other site 264198011880 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264198011881 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 264198011882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198011883 ATP binding site [chemical binding]; other site 264198011884 putative Mg++ binding site [ion binding]; other site 264198011885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198011886 nucleotide binding region [chemical binding]; other site 264198011887 ATP-binding site [chemical binding]; other site 264198011888 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 264198011889 HRDC domain; Region: HRDC; pfam00570 264198011890 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 264198011891 putative deacylase active site [active] 264198011892 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 264198011893 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264198011894 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 264198011895 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264198011896 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264198011897 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264198011898 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 264198011899 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264198011900 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264198011901 DNA binding site [nucleotide binding] 264198011902 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264198011903 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 264198011904 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 264198011905 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 264198011906 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264198011907 RPB11 interaction site [polypeptide binding]; other site 264198011908 RPB12 interaction site [polypeptide binding]; other site 264198011909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264198011910 RPB3 interaction site [polypeptide binding]; other site 264198011911 RPB1 interaction site [polypeptide binding]; other site 264198011912 RPB11 interaction site [polypeptide binding]; other site 264198011913 RPB10 interaction site [polypeptide binding]; other site 264198011914 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264198011915 core dimer interface [polypeptide binding]; other site 264198011916 peripheral dimer interface [polypeptide binding]; other site 264198011917 L10 interface [polypeptide binding]; other site 264198011918 L11 interface [polypeptide binding]; other site 264198011919 putative EF-Tu interaction site [polypeptide binding]; other site 264198011920 putative EF-G interaction site [polypeptide binding]; other site 264198011921 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264198011922 23S rRNA interface [nucleotide binding]; other site 264198011923 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264198011924 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264198011925 mRNA/rRNA interface [nucleotide binding]; other site 264198011926 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264198011927 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264198011928 23S rRNA interface [nucleotide binding]; other site 264198011929 L7/L12 interface [polypeptide binding]; other site 264198011930 putative thiostrepton binding site; other site 264198011931 L25 interface [polypeptide binding]; other site 264198011932 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264198011933 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264198011934 putative homodimer interface [polypeptide binding]; other site 264198011935 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 264198011936 heterodimer interface [polypeptide binding]; other site 264198011937 homodimer interface [polypeptide binding]; other site 264198011938 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 264198011939 elongation factor Tu; Reviewed; Region: PRK00049 264198011940 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264198011941 G1 box; other site 264198011942 GEF interaction site [polypeptide binding]; other site 264198011943 GTP/Mg2+ binding site [chemical binding]; other site 264198011944 Switch I region; other site 264198011945 G2 box; other site 264198011946 G3 box; other site 264198011947 Switch II region; other site 264198011948 G4 box; other site 264198011949 G5 box; other site 264198011950 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264198011951 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264198011952 Antibiotic Binding Site [chemical binding]; other site 264198011953 Protein of unknown function, DUF488; Region: DUF488; cl01246 264198011954 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 264198011955 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 264198011956 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264198011957 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198011958 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198011959 Ligand Binding Site [chemical binding]; other site 264198011960 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 264198011961 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 264198011962 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264198011963 putative catalytic site [active] 264198011964 putative metal binding site [ion binding]; other site 264198011965 putative phosphate binding site [ion binding]; other site 264198011966 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 264198011967 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 264198011968 putative active site [active] 264198011969 catalytic site [active] 264198011970 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 264198011971 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198011972 putative active site [active] 264198011973 putative active site [active] 264198011974 catalytic site [active] 264198011975 catalytic site [active] 264198011976 Uncharacterized conserved protein [Function unknown]; Region: COG0398 264198011977 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 264198011978 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 264198011979 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 264198011980 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 264198011981 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 264198011982 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 264198011983 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 264198011984 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 264198011985 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 264198011986 FAD binding pocket [chemical binding]; other site 264198011987 FAD binding motif [chemical binding]; other site 264198011988 phosphate binding motif [ion binding]; other site 264198011989 beta-alpha-beta structure motif; other site 264198011990 NAD(p) ribose binding residues [chemical binding]; other site 264198011991 NAD binding pocket [chemical binding]; other site 264198011992 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 264198011993 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198011994 catalytic loop [active] 264198011995 iron binding site [ion binding]; other site 264198011996 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 264198011997 Protein of unknown function; Region: DUF3658; pfam12395 264198011998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198011999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198012000 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264198012001 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198012002 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 264198012003 TrkA-N domain; Region: TrkA_N; pfam02254 264198012004 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198012005 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198012006 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264198012007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198012008 Coenzyme A binding pocket [chemical binding]; other site 264198012009 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198012010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198012011 putative DNA binding site [nucleotide binding]; other site 264198012012 putative Zn2+ binding site [ion binding]; other site 264198012013 AsnC family; Region: AsnC_trans_reg; pfam01037 264198012014 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 264198012015 EF-hand domain pair; Region: EF_hand_5; pfam13499 264198012016 pseudo EF-hand loop; other site 264198012017 EF-hand domain pair; Region: EF_hand_5; pfam13499 264198012018 Ca2+ binding site [ion binding]; other site 264198012019 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 264198012020 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 264198012021 heme-binding site [chemical binding]; other site 264198012022 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 264198012023 FAD binding pocket [chemical binding]; other site 264198012024 FAD binding motif [chemical binding]; other site 264198012025 phosphate binding motif [ion binding]; other site 264198012026 beta-alpha-beta structure motif; other site 264198012027 NAD binding pocket [chemical binding]; other site 264198012028 Heme binding pocket [chemical binding]; other site 264198012029 Predicted transcriptional regulator [Transcription]; Region: COG1959 264198012030 Transcriptional regulator; Region: Rrf2; cl17282 264198012031 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 264198012032 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 264198012033 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 264198012034 Type II transport protein GspH; Region: GspH; pfam12019 264198012035 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 264198012036 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 264198012037 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 264198012038 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 264198012039 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 264198012040 GspL periplasmic domain; Region: GspL_C; cl14909 264198012041 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 264198012042 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 264198012043 type II secretion system protein D; Region: type_II_gspD; TIGR02517 264198012044 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198012045 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198012046 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198012047 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198012048 type II secretion system protein E; Region: type_II_gspE; TIGR02533 264198012049 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264198012050 Walker A motif; other site 264198012051 ATP binding site [chemical binding]; other site 264198012052 Walker B motif; other site 264198012053 type II secretion system protein F; Region: GspF; TIGR02120 264198012054 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198012055 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198012056 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 264198012057 putative metal binding site [ion binding]; other site 264198012058 Uncharacterized conserved protein [Function unknown]; Region: COG1432 264198012059 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 264198012060 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198012061 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198012062 dimer interface [polypeptide binding]; other site 264198012063 PYR/PP interface [polypeptide binding]; other site 264198012064 TPP binding site [chemical binding]; other site 264198012065 substrate binding site [chemical binding]; other site 264198012066 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 264198012067 TPP-binding site; other site 264198012068 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264198012069 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 264198012070 Uncharacterized conserved protein [Function unknown]; Region: COG3791 264198012071 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 264198012072 dimer interface [polypeptide binding]; other site 264198012073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198012074 metal binding site [ion binding]; metal-binding site 264198012075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198012076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012077 putative substrate translocation pore; other site 264198012078 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 264198012079 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264198012080 putative active site [active] 264198012081 metal binding site [ion binding]; metal-binding site 264198012082 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 264198012083 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 264198012084 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264198012085 Walker A/P-loop; other site 264198012086 ATP binding site [chemical binding]; other site 264198012087 Q-loop/lid; other site 264198012088 ABC transporter signature motif; other site 264198012089 Walker B; other site 264198012090 D-loop; other site 264198012091 H-loop/switch region; other site 264198012092 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264198012093 Cation efflux family; Region: Cation_efflux; pfam01545 264198012094 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198012095 MarR family; Region: MarR_2; cl17246 264198012096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198012098 putative substrate translocation pore; other site 264198012099 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 264198012100 active site 264198012101 metal binding site [ion binding]; metal-binding site 264198012102 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 264198012103 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264198012104 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264198012105 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198012106 catalytic residues [active] 264198012107 Uncharacterized conserved protein [Function unknown]; Region: COG1416 264198012108 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 264198012109 Predicted secreted protein [Function unknown]; Region: COG5501 264198012110 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 264198012111 Cytochrome c; Region: Cytochrom_C; cl11414 264198012112 Cytochrome c; Region: Cytochrom_C; pfam00034 264198012113 Cytochrome c; Region: Cytochrom_C; cl11414 264198012114 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 264198012115 Moco binding site; other site 264198012116 metal coordination site [ion binding]; other site 264198012117 dimerization interface [polypeptide binding]; other site 264198012118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198012119 dimerization interface [polypeptide binding]; other site 264198012120 putative DNA binding site [nucleotide binding]; other site 264198012121 putative Zn2+ binding site [ion binding]; other site 264198012122 EamA-like transporter family; Region: EamA; pfam00892 264198012123 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198012124 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264198012125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198012126 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 264198012127 Cytochrome c; Region: Cytochrom_C; cl11414 264198012128 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198012129 BON domain; Region: BON; pfam04972 264198012130 BON domain; Region: BON; pfam04972 264198012131 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 264198012132 dimer interface [polypeptide binding]; other site 264198012133 active site 264198012134 hypothetical protein; Provisional; Region: PRK14673 264198012135 Predicted methyltransferases [General function prediction only]; Region: COG0313 264198012136 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 264198012137 putative SAM binding site [chemical binding]; other site 264198012138 putative homodimer interface [polypeptide binding]; other site 264198012139 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 264198012140 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 264198012141 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198012142 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 264198012143 ArsC family; Region: ArsC; pfam03960 264198012144 catalytic residues [active] 264198012145 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 264198012146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 264198012147 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198012148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198012149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198012150 Coenzyme A binding pocket [chemical binding]; other site 264198012151 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264198012152 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264198012153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198012154 MarR family; Region: MarR_2; pfam12802 264198012155 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 264198012156 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 264198012157 putative metal binding site [ion binding]; other site 264198012158 allantoate amidohydrolase; Reviewed; Region: PRK12890 264198012159 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 264198012160 active site 264198012161 metal binding site [ion binding]; metal-binding site 264198012162 dimer interface [polypeptide binding]; other site 264198012163 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 264198012164 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198012165 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198012166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012167 DNA-binding site [nucleotide binding]; DNA binding site 264198012168 FCD domain; Region: FCD; pfam07729 264198012169 short chain dehydrogenase; Provisional; Region: PRK07576 264198012170 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 264198012171 NAD(P) binding site [chemical binding]; other site 264198012172 substrate binding site [chemical binding]; other site 264198012173 homotetramer interface [polypeptide binding]; other site 264198012174 active site 264198012175 homodimer interface [polypeptide binding]; other site 264198012176 enoyl-CoA hydratase; Provisional; Region: PRK08140 264198012177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198012178 substrate binding site [chemical binding]; other site 264198012179 oxyanion hole (OAH) forming residues; other site 264198012180 trimer interface [polypeptide binding]; other site 264198012181 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 264198012182 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 264198012183 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 264198012184 dimer interface [polypeptide binding]; other site 264198012185 acyl-activating enzyme (AAE) consensus motif; other site 264198012186 putative active site [active] 264198012187 AMP binding site [chemical binding]; other site 264198012188 putative CoA binding site [chemical binding]; other site 264198012189 enoyl-CoA hydratase; Provisional; Region: PRK07509 264198012190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198012191 substrate binding site [chemical binding]; other site 264198012192 oxyanion hole (OAH) forming residues; other site 264198012193 trimer interface [polypeptide binding]; other site 264198012194 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 264198012195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012196 transcriptional activator TtdR; Provisional; Region: PRK09801 264198012197 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198012198 putative effector binding pocket; other site 264198012199 dimerization interface [polypeptide binding]; other site 264198012200 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 264198012201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012202 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198012203 dimerization interface [polypeptide binding]; other site 264198012204 citrate-proton symporter; Provisional; Region: PRK15075 264198012205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012206 putative substrate translocation pore; other site 264198012207 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198012208 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198012209 metal binding site [ion binding]; metal-binding site 264198012210 putative dimer interface [polypeptide binding]; other site 264198012211 glyoxylate carboligase; Provisional; Region: PRK11269 264198012212 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198012213 PYR/PP interface [polypeptide binding]; other site 264198012214 dimer interface [polypeptide binding]; other site 264198012215 TPP binding site [chemical binding]; other site 264198012216 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198012217 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198012218 TPP-binding site [chemical binding]; other site 264198012219 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 264198012220 tartronate semialdehyde reductase; Provisional; Region: PRK15059 264198012221 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198012222 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 264198012223 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 264198012224 MOFRL family; Region: MOFRL; pfam05161 264198012225 pyruvate kinase; Provisional; Region: PRK06247 264198012226 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 264198012227 domain interfaces; other site 264198012228 active site 264198012229 Predicted metalloprotease [General function prediction only]; Region: COG2321 264198012230 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 264198012231 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 264198012232 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264198012233 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 264198012234 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 264198012235 DNA binding residues [nucleotide binding] 264198012236 dimer interface [polypeptide binding]; other site 264198012237 putative metal binding site [ion binding]; other site 264198012238 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 264198012239 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 264198012240 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 264198012241 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 264198012242 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 264198012243 Short C-terminal domain; Region: SHOCT; pfam09851 264198012244 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 264198012245 spermidine synthase; Provisional; Region: PRK03612 264198012246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198012247 S-adenosylmethionine binding site [chemical binding]; other site 264198012248 heat shock protein HtpX; Provisional; Region: PRK05457 264198012249 FemAB family; Region: FemAB; pfam02388 264198012250 hypothetical protein; Provisional; Region: PRK09256 264198012251 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264198012252 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 264198012253 catalytic residues [active] 264198012254 catalytic nucleophile [active] 264198012255 Recombinase; Region: Recombinase; pfam07508 264198012256 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264198012257 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264198012258 catalytic residues [active] 264198012259 catalytic nucleophile [active] 264198012260 Presynaptic Site I dimer interface [polypeptide binding]; other site 264198012261 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 264198012262 Synaptic Flat tetramer interface [polypeptide binding]; other site 264198012263 Synaptic Site I dimer interface [polypeptide binding]; other site 264198012264 DNA binding site [nucleotide binding] 264198012265 FAD binding domain; Region: FAD_binding_4; pfam01565 264198012266 Berberine and berberine like; Region: BBE; pfam08031 264198012267 MltA-interacting protein MipA; Region: MipA; cl01504 264198012268 Cytochrome c; Region: Cytochrom_C; cl11414 264198012269 Cytochrome c; Region: Cytochrom_C; cl11414 264198012270 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 264198012271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198012272 FeS/SAM binding site; other site 264198012273 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198012274 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264198012275 HAMP domain; Region: HAMP; pfam00672 264198012276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012277 dimer interface [polypeptide binding]; other site 264198012278 phosphorylation site [posttranslational modification] 264198012279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012280 ATP binding site [chemical binding]; other site 264198012281 Mg2+ binding site [ion binding]; other site 264198012282 G-X-G motif; other site 264198012283 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198012284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012285 active site 264198012286 phosphorylation site [posttranslational modification] 264198012287 intermolecular recognition site; other site 264198012288 dimerization interface [polypeptide binding]; other site 264198012289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198012290 DNA binding site [nucleotide binding] 264198012291 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 264198012292 Part of AAA domain; Region: AAA_19; pfam13245 264198012293 Family description; Region: UvrD_C_2; pfam13538 264198012294 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264198012295 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198012296 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264198012297 lipoyl attachment site [posttranslational modification]; other site 264198012298 glycine dehydrogenase; Provisional; Region: PRK05367 264198012299 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264198012300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198012301 tetramer interface [polypeptide binding]; other site 264198012302 catalytic residue [active] 264198012303 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264198012304 tetramer interface [polypeptide binding]; other site 264198012305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198012306 catalytic residue [active] 264198012307 Predicted membrane protein [Function unknown]; Region: COG2323 264198012308 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264198012309 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264198012310 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 264198012311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198012312 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 264198012313 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 264198012314 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198012315 Tetratricopeptide repeat; Region: TPR_9; pfam13371 264198012316 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198012317 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198012318 dimerization interface [polypeptide binding]; other site 264198012319 ligand binding site [chemical binding]; other site 264198012320 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 264198012321 Predicted transcriptional regulator [Transcription]; Region: COG3905 264198012322 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 264198012323 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 264198012324 Glutamate binding site [chemical binding]; other site 264198012325 NAD binding site [chemical binding]; other site 264198012326 catalytic residues [active] 264198012327 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 264198012328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198012329 ATP binding site [chemical binding]; other site 264198012330 putative Mg++ binding site [ion binding]; other site 264198012331 helicase superfamily c-terminal domain; Region: HELICc; smart00490 264198012332 ATP-binding site [chemical binding]; other site 264198012333 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 264198012334 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 264198012335 substrate binding site [chemical binding]; other site 264198012336 active site 264198012337 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198012338 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 264198012339 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 264198012340 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 264198012341 gamma subunit interface [polypeptide binding]; other site 264198012342 epsilon subunit interface [polypeptide binding]; other site 264198012343 LBP interface [polypeptide binding]; other site 264198012344 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264198012345 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264198012346 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264198012347 alpha subunit interaction interface [polypeptide binding]; other site 264198012348 Walker A motif; other site 264198012349 ATP binding site [chemical binding]; other site 264198012350 Walker B motif; other site 264198012351 inhibitor binding site; inhibition site 264198012352 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264198012353 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 264198012354 core domain interface [polypeptide binding]; other site 264198012355 delta subunit interface [polypeptide binding]; other site 264198012356 epsilon subunit interface [polypeptide binding]; other site 264198012357 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264198012358 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264198012359 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264198012360 beta subunit interaction interface [polypeptide binding]; other site 264198012361 Walker A motif; other site 264198012362 ATP binding site [chemical binding]; other site 264198012363 Walker B motif; other site 264198012364 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264198012365 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 264198012366 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264198012367 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264198012368 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 264198012369 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 264198012370 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 264198012371 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 264198012372 ATP synthase I chain; Region: ATP_synt_I; cl09170 264198012373 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264198012374 ParB-like nuclease domain; Region: ParB; smart00470 264198012375 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264198012376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198012377 P-loop; other site 264198012378 Magnesium ion binding site [ion binding]; other site 264198012379 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198012380 Magnesium ion binding site [ion binding]; other site 264198012381 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 264198012382 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 264198012383 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264198012384 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 264198012385 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264198012386 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 264198012387 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012388 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198012389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012390 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198012391 dimerization interface [polypeptide binding]; other site 264198012392 substrate binding pocket [chemical binding]; other site 264198012393 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198012394 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198012395 Walker A/P-loop; other site 264198012396 ATP binding site [chemical binding]; other site 264198012397 Q-loop/lid; other site 264198012398 ABC transporter signature motif; other site 264198012399 Walker B; other site 264198012400 D-loop; other site 264198012401 H-loop/switch region; other site 264198012402 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198012403 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198012404 TM-ABC transporter signature motif; other site 264198012405 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198012406 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198012407 Walker A/P-loop; other site 264198012408 ATP binding site [chemical binding]; other site 264198012409 Q-loop/lid; other site 264198012410 ABC transporter signature motif; other site 264198012411 Walker B; other site 264198012412 D-loop; other site 264198012413 H-loop/switch region; other site 264198012414 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198012415 TM-ABC transporter signature motif; other site 264198012416 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198012417 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 264198012418 putative ligand binding site [chemical binding]; other site 264198012419 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198012420 hypothetical protein; Provisional; Region: PRK10621 264198012421 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198012422 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198012423 TM-ABC transporter signature motif; other site 264198012424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198012425 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198012426 TM-ABC transporter signature motif; other site 264198012427 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198012428 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198012429 putative ligand binding site [chemical binding]; other site 264198012430 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198012431 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198012432 Walker A/P-loop; other site 264198012433 ATP binding site [chemical binding]; other site 264198012434 Q-loop/lid; other site 264198012435 ABC transporter signature motif; other site 264198012436 Walker B; other site 264198012437 D-loop; other site 264198012438 H-loop/switch region; other site 264198012439 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198012440 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198012441 Walker A/P-loop; other site 264198012442 ATP binding site [chemical binding]; other site 264198012443 Q-loop/lid; other site 264198012444 ABC transporter signature motif; other site 264198012445 Walker B; other site 264198012446 D-loop; other site 264198012447 H-loop/switch region; other site 264198012448 choline dehydrogenase; Validated; Region: PRK02106 264198012449 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198012450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198012453 dimerization interface [polypeptide binding]; other site 264198012454 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264198012455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198012456 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 264198012457 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 264198012458 DNA binding residues [nucleotide binding] 264198012459 dimer interface [polypeptide binding]; other site 264198012460 copper binding site [ion binding]; other site 264198012461 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198012462 metal-binding site [ion binding] 264198012463 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264198012464 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198012465 metal-binding site [ion binding] 264198012466 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198012467 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264198012468 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198012469 metal-binding site [ion binding] 264198012470 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 264198012471 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 264198012472 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198012473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198012474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198012475 ornithine cyclodeaminase; Validated; Region: PRK07340 264198012476 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 264198012477 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198012478 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198012479 active site 264198012480 catalytic tetrad [active] 264198012481 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 264198012482 Transglycosylase; Region: Transgly; pfam00912 264198012483 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264198012484 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 264198012485 Predicted membrane protein [Function unknown]; Region: COG3714 264198012486 MG2 domain; Region: A2M_N; pfam01835 264198012487 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 264198012488 Alpha-2-macroglobulin family; Region: A2M; pfam00207 264198012489 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198012490 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 264198012491 putative DNA binding site [nucleotide binding]; other site 264198012492 putative Zn2+ binding site [ion binding]; other site 264198012493 AsnC family; Region: AsnC_trans_reg; pfam01037 264198012494 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 264198012495 cofactor binding site; other site 264198012496 metal binding site [ion binding]; metal-binding site 264198012497 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 264198012498 aromatic arch; other site 264198012499 DCoH dimer interaction site [polypeptide binding]; other site 264198012500 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 264198012501 DCoH tetramer interaction site [polypeptide binding]; other site 264198012502 substrate binding site [chemical binding]; other site 264198012503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198012504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012505 active site 264198012506 phosphorylation site [posttranslational modification] 264198012507 intermolecular recognition site; other site 264198012508 dimerization interface [polypeptide binding]; other site 264198012509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198012510 DNA binding site [nucleotide binding] 264198012511 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198012512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198012514 dimer interface [polypeptide binding]; other site 264198012515 phosphorylation site [posttranslational modification] 264198012516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012517 ATP binding site [chemical binding]; other site 264198012518 Mg2+ binding site [ion binding]; other site 264198012519 G-X-G motif; other site 264198012520 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 264198012521 Proteins containing SET domain [General function prediction only]; Region: COG2940 264198012522 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198012523 IHF dimer interface [polypeptide binding]; other site 264198012524 IHF - DNA interface [nucleotide binding]; other site 264198012525 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030 264198012526 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264198012527 active site 264198012528 DNA polymerase IV; Validated; Region: PRK02406 264198012529 DNA binding site [nucleotide binding] 264198012530 Predicted permeases [General function prediction only]; Region: RarD; COG2962 264198012531 EamA-like transporter family; Region: EamA; pfam00892 264198012532 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 264198012533 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198012534 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 264198012535 trimer interface; other site 264198012536 sugar binding site [chemical binding]; other site 264198012537 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 264198012538 Asn-Pro-Ala signature motifs; other site 264198012539 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 264198012540 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 264198012541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198012542 metal binding site [ion binding]; metal-binding site 264198012543 active site 264198012544 I-site; other site 264198012545 Response regulator receiver domain; Region: Response_reg; pfam00072 264198012546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012547 active site 264198012548 phosphorylation site [posttranslational modification] 264198012549 intermolecular recognition site; other site 264198012550 dimerization interface [polypeptide binding]; other site 264198012551 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 264198012552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198012553 dimerization interface [polypeptide binding]; other site 264198012554 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264198012555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012556 dimer interface [polypeptide binding]; other site 264198012557 phosphorylation site [posttranslational modification] 264198012558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012559 ATP binding site [chemical binding]; other site 264198012560 Mg2+ binding site [ion binding]; other site 264198012561 G-X-G motif; other site 264198012562 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 264198012563 16S rRNA methyltransferase B; Provisional; Region: PRK10901 264198012564 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 264198012565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198012566 S-adenosylmethionine binding site [chemical binding]; other site 264198012567 M48 family peptidase; Provisional; Region: PRK03001 264198012568 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264198012569 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264198012570 putative active site [active] 264198012571 substrate binding site [chemical binding]; other site 264198012572 putative cosubstrate binding site; other site 264198012573 catalytic site [active] 264198012574 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264198012575 substrate binding site [chemical binding]; other site 264198012576 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264198012577 active site 264198012578 catalytic residues [active] 264198012579 metal binding site [ion binding]; metal-binding site 264198012580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198012581 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 264198012582 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 264198012583 DNA protecting protein DprA; Region: dprA; TIGR00732 264198012584 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198012585 catalytic residues [active] 264198012586 DNA topoisomerase III; Validated; Region: PRK08173 264198012587 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264198012588 active site 264198012589 putative interdomain interaction site [polypeptide binding]; other site 264198012590 putative metal-binding site [ion binding]; other site 264198012591 putative nucleotide binding site [chemical binding]; other site 264198012592 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264198012593 domain I; other site 264198012594 DNA binding groove [nucleotide binding] 264198012595 phosphate binding site [ion binding]; other site 264198012596 domain II; other site 264198012597 domain III; other site 264198012598 nucleotide binding site [chemical binding]; other site 264198012599 catalytic site [active] 264198012600 domain IV; other site 264198012601 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264198012602 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264198012603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012605 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198012606 putative effector binding pocket; other site 264198012607 dimerization interface [polypeptide binding]; other site 264198012608 Protein of unknown function (DUF466); Region: DUF466; pfam04328 264198012609 carbon starvation protein A; Provisional; Region: PRK15015 264198012610 Carbon starvation protein CstA; Region: CstA; pfam02554 264198012611 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 264198012612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 264198012613 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 264198012614 Histidine kinase; Region: HisKA_3; pfam07730 264198012615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012616 ATP binding site [chemical binding]; other site 264198012617 Mg2+ binding site [ion binding]; other site 264198012618 G-X-G motif; other site 264198012619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198012620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012621 active site 264198012622 phosphorylation site [posttranslational modification] 264198012623 intermolecular recognition site; other site 264198012624 dimerization interface [polypeptide binding]; other site 264198012625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012626 DNA binding residues [nucleotide binding] 264198012627 dimerization interface [polypeptide binding]; other site 264198012628 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 264198012629 active site 264198012630 substrate-binding site [chemical binding]; other site 264198012631 metal-binding site [ion binding] 264198012632 GTP binding site [chemical binding]; other site 264198012633 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198012634 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 264198012635 dimerization interface [polypeptide binding]; other site 264198012636 NAD binding site [chemical binding]; other site 264198012637 ligand binding site [chemical binding]; other site 264198012638 catalytic site [active] 264198012639 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198012640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012641 putative substrate translocation pore; other site 264198012642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 264198012643 MOSC domain; Region: MOSC; pfam03473 264198012644 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198012645 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198012646 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198012647 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198012648 Protein of unknown function, DUF399; Region: DUF399; pfam04187 264198012649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012650 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264198012651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 264198012652 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264198012653 Putative ammonia monooxygenase; Region: AmoA; pfam05145 264198012654 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264198012655 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198012656 CoenzymeA binding site [chemical binding]; other site 264198012657 subunit interaction site [polypeptide binding]; other site 264198012658 PHB binding site; other site 264198012659 Patatin-like phospholipase; Region: Patatin; pfam01734 264198012660 active site 264198012661 nucleophile elbow; other site 264198012662 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264198012663 glutathione reductase; Validated; Region: PRK06116 264198012664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198012665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198012666 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198012667 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198012668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012669 dimer interface [polypeptide binding]; other site 264198012670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012671 ATP binding site [chemical binding]; other site 264198012672 Mg2+ binding site [ion binding]; other site 264198012673 G-X-G motif; other site 264198012674 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264198012675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012676 active site 264198012677 phosphorylation site [posttranslational modification] 264198012678 intermolecular recognition site; other site 264198012679 dimerization interface [polypeptide binding]; other site 264198012680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198012681 DNA binding site [nucleotide binding] 264198012682 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198012683 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264198012684 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 264198012685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198012686 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 264198012687 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 264198012688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198012689 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198012690 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198012691 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198012692 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 264198012693 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 264198012694 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 264198012695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198012696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198012697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012698 cell density-dependent motility repressor; Provisional; Region: PRK10082 264198012699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198012700 dimerization interface [polypeptide binding]; other site 264198012701 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012702 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 264198012703 putative active site [active] 264198012704 Zn binding site [ion binding]; other site 264198012705 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 264198012706 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 264198012707 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 264198012708 homodimer interface [polypeptide binding]; other site 264198012709 active site 264198012710 TDP-binding site; other site 264198012711 acceptor substrate-binding pocket; other site 264198012712 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264198012713 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 264198012714 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 264198012715 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264198012716 oligomeric interface; other site 264198012717 putative active site [active] 264198012718 homodimer interface [polypeptide binding]; other site 264198012719 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264198012720 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264198012721 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264198012722 G1 box; other site 264198012723 GTP/Mg2+ binding site [chemical binding]; other site 264198012724 Switch I region; other site 264198012725 G2 box; other site 264198012726 Switch II region; other site 264198012727 G3 box; other site 264198012728 G4 box; other site 264198012729 G5 box; other site 264198012730 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264198012731 CHAD domain; Region: CHAD; pfam05235 264198012732 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198012733 CoenzymeA binding site [chemical binding]; other site 264198012734 subunit interaction site [polypeptide binding]; other site 264198012735 PHB binding site; other site 264198012736 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 264198012737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198012738 S-adenosylmethionine binding site [chemical binding]; other site 264198012739 membrane protein insertase; Provisional; Region: PRK01318 264198012740 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 264198012741 hypothetical protein; Validated; Region: PRK00041 264198012742 Ribonuclease P; Region: Ribonuclease_P; cl00457 264198012743 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 264198012744 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 264198012745 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 264198012746 substrate binding site [chemical binding]; other site 264198012747 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 264198012748 substrate binding site [chemical binding]; other site 264198012749 ligand binding site [chemical binding]; other site 264198012750 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198012751 Helix-turn-helix domain; Region: HTH_37; pfam13744 264198012752 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 264198012753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198012754 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 264198012755 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264198012756 short chain dehydrogenase; Provisional; Region: PRK08265 264198012757 classical (c) SDRs; Region: SDR_c; cd05233 264198012758 NAD(P) binding site [chemical binding]; other site 264198012759 active site 264198012760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198012761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198012762 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 264198012763 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 264198012764 molybdenum-pterin binding domain; Region: Mop; TIGR00638 264198012765 TOBE domain; Region: TOBE; cl01440 264198012766 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198012767 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198012768 homotrimer interaction site [polypeptide binding]; other site 264198012769 putative active site [active] 264198012770 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 264198012771 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012772 Cytochrome c2 [Energy production and conversion]; Region: COG3474 264198012773 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 264198012774 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264198012775 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 264198012776 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 264198012777 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198012778 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198012779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198012780 membrane-bound complex binding site; other site 264198012781 short chain dehydrogenase; Provisional; Region: PRK12937 264198012782 classical (c) SDRs; Region: SDR_c; cd05233 264198012783 NAD(P) binding site [chemical binding]; other site 264198012784 active site 264198012785 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012787 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198012788 putative effector binding pocket; other site 264198012789 dimerization interface [polypeptide binding]; other site 264198012790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 264198012791 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 264198012792 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198012793 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 264198012794 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264198012795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198012796 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198012797 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 264198012798 C-terminal domain interface [polypeptide binding]; other site 264198012799 GSH binding site (G-site) [chemical binding]; other site 264198012800 dimer interface [polypeptide binding]; other site 264198012801 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 264198012802 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198012803 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264198012804 C-terminal domain interface [polypeptide binding]; other site 264198012805 GSH binding site (G-site) [chemical binding]; other site 264198012806 dimer interface [polypeptide binding]; other site 264198012807 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 264198012808 dimer interface [polypeptide binding]; other site 264198012809 N-terminal domain interface [polypeptide binding]; other site 264198012810 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264198012811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198012812 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198012813 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198012814 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198012815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012817 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198012818 dimerization interface [polypeptide binding]; other site 264198012819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012821 active site 264198012822 Outer membrane efflux protein; Region: OEP; pfam02321 264198012823 Outer membrane efflux protein; Region: OEP; pfam02321 264198012824 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198012825 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198012826 E3 interaction surface; other site 264198012827 lipoyl attachment site [posttranslational modification]; other site 264198012828 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198012829 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264198012830 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 264198012831 CsbD-like; Region: CsbD; cl17424 264198012832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198012833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012834 dimer interface [polypeptide binding]; other site 264198012835 phosphorylation site [posttranslational modification] 264198012836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012837 ATP binding site [chemical binding]; other site 264198012838 Mg2+ binding site [ion binding]; other site 264198012839 G-X-G motif; other site 264198012840 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198012841 active site 264198012842 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264198012843 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198012844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012845 DNA-binding site [nucleotide binding]; DNA binding site 264198012846 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198012847 hypothetical protein; Validated; Region: PRK07586 264198012848 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198012849 PYR/PP interface [polypeptide binding]; other site 264198012850 dimer interface [polypeptide binding]; other site 264198012851 TPP binding site [chemical binding]; other site 264198012852 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 264198012853 TPP-binding site [chemical binding]; other site 264198012854 dimer interface [polypeptide binding]; other site 264198012855 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198012856 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198012857 thiolase; Provisional; Region: PRK06158 264198012858 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198012859 active site 264198012860 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012861 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198012862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198012863 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198012864 acyl-activating enzyme (AAE) consensus motif; other site 264198012865 putative AMP binding site [chemical binding]; other site 264198012866 putative active site [active] 264198012867 putative CoA binding site [chemical binding]; other site 264198012868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012869 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198012870 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198012871 active site 264198012872 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198012873 Phosphotransferase enzyme family; Region: APH; pfam01636 264198012874 putative active site [active] 264198012875 putative substrate binding site [chemical binding]; other site 264198012876 ATP binding site [chemical binding]; other site 264198012877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198012878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198012879 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 264198012880 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 264198012881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198012882 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 264198012883 DXD motif; other site 264198012884 PilZ domain; Region: PilZ; pfam07238 264198012885 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 264198012886 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198012887 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 264198012888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198012889 binding surface 264198012890 TPR motif; other site 264198012891 TPR repeat; Region: TPR_11; pfam13414 264198012892 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 264198012893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198012894 binding surface 264198012895 TPR motif; other site 264198012896 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 264198012897 endo-1,4-D-glucanase; Provisional; Region: PRK11097 264198012898 cellulose synthase regulator protein; Provisional; Region: PRK11114 264198012899 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198012900 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198012901 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198012902 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 264198012903 ligand binding site [chemical binding]; other site 264198012904 NAD binding site [chemical binding]; other site 264198012905 dimerization interface [polypeptide binding]; other site 264198012906 catalytic site [active] 264198012907 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198012908 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012909 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198012910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012911 DNA-binding site [nucleotide binding]; DNA binding site 264198012912 UTRA domain; Region: UTRA; pfam07702 264198012913 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198012914 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198012915 active site 264198012916 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198012917 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198012918 FAD binding site [chemical binding]; other site 264198012919 substrate binding site [chemical binding]; other site 264198012920 catalytic base [active] 264198012921 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198012922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198012923 acyl-activating enzyme (AAE) consensus motif; other site 264198012924 AMP binding site [chemical binding]; other site 264198012925 active site 264198012926 CoA binding site [chemical binding]; other site 264198012927 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012928 Uncharacterized conserved protein [Function unknown]; Region: COG3777 264198012929 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198012930 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198012931 active site 2 [active] 264198012932 active site 1 [active] 264198012933 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 264198012934 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 264198012935 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012936 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012939 active site 264198012940 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 264198012941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012943 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198012944 putative dimerization interface [polypeptide binding]; other site 264198012945 short chain dehydrogenase; Provisional; Region: PRK07791 264198012946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012947 NAD(P) binding site [chemical binding]; other site 264198012948 active site 264198012949 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012950 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012951 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198012952 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198012953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198012954 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012955 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 264198012956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198012957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198012958 acyl-activating enzyme (AAE) consensus motif; other site 264198012959 AMP binding site [chemical binding]; other site 264198012960 active site 264198012961 CoA binding site [chemical binding]; other site 264198012962 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012963 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198012964 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198012965 substrate binding site [chemical binding]; other site 264198012966 oxyanion hole (OAH) forming residues; other site 264198012967 trimer interface [polypeptide binding]; other site 264198012968 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012969 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012970 active site 264198012971 PrkA family serine protein kinase; Provisional; Region: PRK15455 264198012972 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 264198012973 hypothetical protein; Provisional; Region: PRK05325 264198012974 SpoVR family protein; Provisional; Region: PRK11767 264198012975 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 264198012976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012979 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198012980 active site 264198012981 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198012982 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 264198012983 active site 264198012984 catalytic site [active] 264198012985 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012986 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198012988 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198012989 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198012990 dimerization interface [polypeptide binding]; other site 264198012991 substrate binding pocket [chemical binding]; other site 264198012992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198012993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012994 DNA binding residues [nucleotide binding] 264198012995 dimerization interface [polypeptide binding]; other site 264198012996 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198012997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012998 NAD(P) binding site [chemical binding]; other site 264198012999 active site 264198013000 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198013001 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198013002 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198013003 acyl-activating enzyme (AAE) consensus motif; other site 264198013004 acyl-activating enzyme (AAE) consensus motif; other site 264198013005 putative AMP binding site [chemical binding]; other site 264198013006 putative active site [active] 264198013007 putative CoA binding site [chemical binding]; other site 264198013008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013009 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198013010 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198013011 trimer interface [polypeptide binding]; other site 264198013012 eyelet of channel; other site 264198013013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198013014 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198013015 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198013016 [2Fe-2S] cluster binding site [ion binding]; other site 264198013017 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198013018 hydrophobic ligand binding site; other site 264198013019 short chain dehydrogenase; Provisional; Region: PRK12939 264198013020 classical (c) SDRs; Region: SDR_c; cd05233 264198013021 NAD(P) binding site [chemical binding]; other site 264198013022 active site 264198013023 Cupin domain; Region: Cupin_2; pfam07883 264198013024 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013025 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198013026 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013027 short chain dehydrogenase; Provisional; Region: PRK07062 264198013028 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 264198013029 putative NAD(P) binding site [chemical binding]; other site 264198013030 putative active site [active] 264198013031 hypothetical protein; Provisional; Region: PRK07064 264198013032 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198013033 PYR/PP interface [polypeptide binding]; other site 264198013034 dimer interface [polypeptide binding]; other site 264198013035 TPP binding site [chemical binding]; other site 264198013036 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198013037 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 264198013038 TPP-binding site [chemical binding]; other site 264198013039 L-aspartate dehydrogenase; Provisional; Region: PRK13303 264198013040 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 264198013041 Domain of unknown function DUF108; Region: DUF108; pfam01958 264198013042 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013043 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 264198013044 NAD(P) binding site [chemical binding]; other site 264198013045 catalytic residues [active] 264198013046 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 264198013047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198013048 putative active site [active] 264198013049 putative metal binding site [ion binding]; other site 264198013050 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198013051 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198013052 FMN-binding pocket [chemical binding]; other site 264198013053 flavin binding motif; other site 264198013054 phosphate binding motif [ion binding]; other site 264198013055 beta-alpha-beta structure motif; other site 264198013056 NAD binding pocket [chemical binding]; other site 264198013057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013058 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264198013059 catalytic loop [active] 264198013060 iron binding site [ion binding]; other site 264198013061 benzoate transport; Region: 2A0115; TIGR00895 264198013062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013063 putative substrate translocation pore; other site 264198013064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013065 cystathionine beta-lyase; Provisional; Region: PRK09028 264198013066 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198013067 homodimer interface [polypeptide binding]; other site 264198013068 substrate-cofactor binding pocket; other site 264198013069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013070 catalytic residue [active] 264198013071 D-cysteine desulfhydrase; Validated; Region: PRK03910 264198013072 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264198013073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198013074 catalytic residue [active] 264198013075 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198013076 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264198013077 Walker A/P-loop; other site 264198013078 ATP binding site [chemical binding]; other site 264198013079 Q-loop/lid; other site 264198013080 ABC transporter signature motif; other site 264198013081 Walker B; other site 264198013082 D-loop; other site 264198013083 H-loop/switch region; other site 264198013084 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198013085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198013086 dimer interface [polypeptide binding]; other site 264198013087 conserved gate region; other site 264198013088 putative PBP binding loops; other site 264198013089 ABC-ATPase subunit interface; other site 264198013090 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198013091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198013092 substrate binding pocket [chemical binding]; other site 264198013093 membrane-bound complex binding site; other site 264198013094 hinge residues; other site 264198013095 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 264198013096 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 264198013097 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198013098 conserved cys residue [active] 264198013099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013100 Putative phosphatase (DUF442); Region: DUF442; cl17385 264198013101 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264198013102 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198013103 PAS fold; Region: PAS_4; pfam08448 264198013104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198013105 putative active site [active] 264198013106 heme pocket [chemical binding]; other site 264198013107 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198013108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198013109 Walker A motif; other site 264198013110 ATP binding site [chemical binding]; other site 264198013111 Walker B motif; other site 264198013112 arginine finger; other site 264198013113 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198013114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198013115 MarR family; Region: MarR_2; pfam12802 264198013116 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013117 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 264198013118 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198013119 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198013120 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198013121 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 264198013122 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198013123 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 264198013124 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198013125 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 264198013126 putative hydrophobic ligand binding site [chemical binding]; other site 264198013127 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198013129 dimerization interface [polypeptide binding]; other site 264198013130 putative Zn2+ binding site [ion binding]; other site 264198013131 putative DNA binding site [nucleotide binding]; other site 264198013132 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013133 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013134 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013135 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198013136 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013137 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198013138 FAD binding domain; Region: FAD_binding_3; pfam01494 264198013139 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 264198013140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013141 active site 264198013142 phosphorylation site [posttranslational modification] 264198013143 intermolecular recognition site; other site 264198013144 dimerization interface [polypeptide binding]; other site 264198013145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013146 DNA binding residues [nucleotide binding] 264198013147 dimerization interface [polypeptide binding]; other site 264198013148 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198013149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013150 active site 264198013151 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198013152 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198013153 active site 264198013154 acyl-CoA synthetase; Provisional; Region: PRK13391 264198013155 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198013156 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198013157 acyl-activating enzyme (AAE) consensus motif; other site 264198013158 acyl-activating enzyme (AAE) consensus motif; other site 264198013159 putative AMP binding site [chemical binding]; other site 264198013160 putative active site [active] 264198013161 putative CoA binding site [chemical binding]; other site 264198013162 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198013163 AAA ATPase domain; Region: AAA_16; pfam13191 264198013164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013165 DNA binding residues [nucleotide binding] 264198013166 dimerization interface [polypeptide binding]; other site 264198013167 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198013168 putative FMN binding site [chemical binding]; other site 264198013169 enoyl-CoA hydratase; Provisional; Region: PRK08260 264198013170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198013171 substrate binding site [chemical binding]; other site 264198013172 oxyanion hole (OAH) forming residues; other site 264198013173 trimer interface [polypeptide binding]; other site 264198013174 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198013175 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198013176 FMN binding site [chemical binding]; other site 264198013177 substrate binding site [chemical binding]; other site 264198013178 putative catalytic residue [active] 264198013179 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198013180 CoenzymeA binding site [chemical binding]; other site 264198013181 subunit interaction site [polypeptide binding]; other site 264198013182 PHB binding site; other site 264198013183 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 264198013184 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198013185 dimer interface [polypeptide binding]; other site 264198013186 active site 264198013187 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198013188 catalytic core [active] 264198013189 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013190 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 264198013191 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264198013192 active site 264198013193 catalytic site [active] 264198013194 substrate binding site [chemical binding]; other site 264198013195 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 264198013196 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264198013197 GIY-YIG motif/motif A; other site 264198013198 active site 264198013199 catalytic site [active] 264198013200 putative DNA binding site [nucleotide binding]; other site 264198013201 metal binding site [ion binding]; metal-binding site 264198013202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198013204 putative substrate translocation pore; other site 264198013205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013206 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198013207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198013208 putative Zn2+ binding site [ion binding]; other site 264198013209 putative DNA binding site [nucleotide binding]; other site 264198013210 transcriptional regulator RcsB; Provisional; Region: PRK10840 264198013211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013212 active site 264198013213 phosphorylation site [posttranslational modification] 264198013214 intermolecular recognition site; other site 264198013215 dimerization interface [polypeptide binding]; other site 264198013216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013217 DNA binding residues [nucleotide binding] 264198013218 dimerization interface [polypeptide binding]; other site 264198013219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198013220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198013221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198013222 dimerization interface [polypeptide binding]; other site 264198013223 Transposase; Region: HTH_Tnp_1; pfam01527 264198013224 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 264198013225 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 264198013226 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 264198013227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198013228 ligand binding site [chemical binding]; other site 264198013229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198013230 putative switch regulator; other site 264198013231 non-specific DNA interactions [nucleotide binding]; other site 264198013232 DNA binding site [nucleotide binding] 264198013233 sequence specific DNA binding site [nucleotide binding]; other site 264198013234 putative cAMP binding site [chemical binding]; other site 264198013235 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 264198013236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013237 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198013238 putative substrate translocation pore; other site 264198013239 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198013240 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198013241 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198013242 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198013243 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264198013244 ligand binding site [chemical binding]; other site 264198013245 Rubredoxin [Energy production and conversion]; Region: COG1773 264198013246 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264198013247 iron binding site [ion binding]; other site 264198013248 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 264198013249 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198013250 Cytochrome c; Region: Cytochrom_C; pfam00034 264198013251 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198013252 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 264198013253 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 264198013254 Subunit I/III interface [polypeptide binding]; other site 264198013255 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 264198013256 Subunit I/III interface [polypeptide binding]; other site 264198013257 Predicted small integral membrane protein [Function unknown]; Region: COG5605 264198013258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 264198013259 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 264198013260 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013261 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198013262 tetramerization interface [polypeptide binding]; other site 264198013263 NAD(P) binding site [chemical binding]; other site 264198013264 catalytic residues [active] 264198013265 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198013266 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198013267 active site 264198013268 nucleophile elbow; other site 264198013269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 264198013270 Double zinc ribbon; Region: DZR; pfam12773 264198013271 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 264198013272 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198013273 cyclase homology domain; Region: CHD; cd07302 264198013274 nucleotidyl binding site; other site 264198013275 metal binding site [ion binding]; metal-binding site 264198013276 dimer interface [polypeptide binding]; other site 264198013277 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198013278 AAA ATPase domain; Region: AAA_16; pfam13191 264198013279 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264198013280 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 264198013281 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264198013282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 264198013283 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 264198013284 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 264198013285 Response regulator receiver domain; Region: Response_reg; pfam00072 264198013286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013287 active site 264198013288 phosphorylation site [posttranslational modification] 264198013289 intermolecular recognition site; other site 264198013290 dimerization interface [polypeptide binding]; other site 264198013291 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198013292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198013293 metal binding site [ion binding]; metal-binding site 264198013294 active site 264198013295 I-site; other site 264198013296 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 264198013297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013298 phosphorylation site [posttranslational modification] 264198013299 intermolecular recognition site; other site 264198013300 CheB methylesterase; Region: CheB_methylest; pfam01339 264198013301 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198013302 putative binding surface; other site 264198013303 active site 264198013304 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264198013305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013306 ATP binding site [chemical binding]; other site 264198013307 Mg2+ binding site [ion binding]; other site 264198013308 G-X-G motif; other site 264198013309 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198013310 Response regulator receiver domain; Region: Response_reg; pfam00072 264198013311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013312 active site 264198013313 phosphorylation site [posttranslational modification] 264198013314 intermolecular recognition site; other site 264198013315 dimerization interface [polypeptide binding]; other site 264198013316 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 264198013317 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264198013318 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 264198013319 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264198013320 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198013321 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264198013322 HAMP domain; Region: HAMP; pfam00672 264198013323 dimerization interface [polypeptide binding]; other site 264198013324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198013325 dimer interface [polypeptide binding]; other site 264198013326 putative CheW interface [polypeptide binding]; other site 264198013327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198013328 metal binding site [ion binding]; metal-binding site 264198013329 active site 264198013330 I-site; other site 264198013331 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198013332 FecR protein; Region: FecR; pfam04773 264198013333 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198013334 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 264198013335 putative ligand binding site [chemical binding]; other site 264198013336 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198013337 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198013338 Walker A/P-loop; other site 264198013339 ATP binding site [chemical binding]; other site 264198013340 Q-loop/lid; other site 264198013341 ABC transporter signature motif; other site 264198013342 Walker B; other site 264198013343 D-loop; other site 264198013344 H-loop/switch region; other site 264198013345 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198013346 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198013347 Walker A/P-loop; other site 264198013348 ATP binding site [chemical binding]; other site 264198013349 Q-loop/lid; other site 264198013350 ABC transporter signature motif; other site 264198013351 Walker B; other site 264198013352 D-loop; other site 264198013353 H-loop/switch region; other site 264198013354 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198013355 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198013356 TM-ABC transporter signature motif; other site 264198013357 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198013358 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198013359 TM-ABC transporter signature motif; other site 264198013360 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198013361 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013362 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013363 short chain dehydrogenase; Provisional; Region: PRK06138 264198013364 classical (c) SDRs; Region: SDR_c; cd05233 264198013365 NAD(P) binding site [chemical binding]; other site 264198013366 active site 264198013367 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198013370 putative substrate translocation pore; other site 264198013371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013372 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198013373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198013374 dimer interface [polypeptide binding]; other site 264198013375 phosphorylation site [posttranslational modification] 264198013376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013377 ATP binding site [chemical binding]; other site 264198013378 Mg2+ binding site [ion binding]; other site 264198013379 G-X-G motif; other site 264198013380 Response regulator receiver domain; Region: Response_reg; pfam00072 264198013381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013382 active site 264198013383 phosphorylation site [posttranslational modification] 264198013384 intermolecular recognition site; other site 264198013385 dimerization interface [polypeptide binding]; other site 264198013386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198013387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013388 active site 264198013389 phosphorylation site [posttranslational modification] 264198013390 intermolecular recognition site; other site 264198013391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013392 DNA binding residues [nucleotide binding] 264198013393 dimerization interface [polypeptide binding]; other site 264198013394 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 264198013395 Sensors of blue-light using FAD; Region: BLUF; pfam04940 264198013396 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198013397 GTP cyclohydrolase I; Provisional; Region: PLN03044 264198013398 active site 264198013399 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 264198013400 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 264198013401 transmembrane helices; other site 264198013402 Transglycosylase; Region: Transgly; pfam00912 264198013403 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264198013404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264198013405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198013406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198013407 Protein of unknown function (DUF779); Region: DUF779; pfam05610 264198013408 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264198013409 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 264198013410 NAD binding site [chemical binding]; other site 264198013411 substrate binding site [chemical binding]; other site 264198013412 catalytic Zn binding site [ion binding]; other site 264198013413 tetramer interface [polypeptide binding]; other site 264198013414 structural Zn binding site [ion binding]; other site 264198013415 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 264198013416 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013417 NAD(P) binding site [chemical binding]; other site 264198013418 catalytic residues [active] 264198013419 hypothetical protein; Provisional; Region: PRK02237 264198013420 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 264198013421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198013423 IucA / IucC family; Region: IucA_IucC; pfam04183 264198013424 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264198013425 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264198013426 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264198013427 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 264198013428 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198013429 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198013430 dimer interface [polypeptide binding]; other site 264198013431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013432 catalytic residue [active] 264198013433 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264198013434 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 264198013435 dimer interface [polypeptide binding]; other site 264198013436 active site 264198013437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198013438 catalytic residues [active] 264198013439 substrate binding site [chemical binding]; other site 264198013440 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264198013441 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198013442 N-terminal plug; other site 264198013443 ligand-binding site [chemical binding]; other site 264198013444 ParB-like nuclease domain; Region: ParBc; pfam02195 264198013445 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 264198013446 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 264198013447 putative active site [active] 264198013448 catalytic residue [active] 264198013449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013450 D-galactonate transporter; Region: 2A0114; TIGR00893 264198013451 putative substrate translocation pore; other site 264198013452 galactarate dehydratase; Region: galactar-dH20; TIGR03248 264198013453 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198013454 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198013455 short chain dehydrogenase; Provisional; Region: PRK06500 264198013456 classical (c) SDRs; Region: SDR_c; cd05233 264198013457 NAD(P) binding site [chemical binding]; other site 264198013458 active site 264198013459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198013460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198013461 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198013462 putative effector binding pocket; other site 264198013463 dimerization interface [polypeptide binding]; other site 264198013464 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 264198013465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198013466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198013467 dimerization interface [polypeptide binding]; other site 264198013468 Lysine efflux permease [General function prediction only]; Region: COG1279 264198013469 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198013470 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198013471 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198013472 putative active site [active] 264198013473 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 264198013474 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 264198013475 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 264198013476 Walker A/P-loop; other site 264198013477 ATP binding site [chemical binding]; other site 264198013478 Q-loop/lid; other site 264198013479 ABC transporter signature motif; other site 264198013480 Walker B; other site 264198013481 D-loop; other site 264198013482 H-loop/switch region; other site 264198013483 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198013484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198013485 dimer interface [polypeptide binding]; other site 264198013486 conserved gate region; other site 264198013487 putative PBP binding loops; other site 264198013488 ABC-ATPase subunit interface; other site 264198013489 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 264198013490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198013491 substrate binding pocket [chemical binding]; other site 264198013492 membrane-bound complex binding site; other site 264198013493 hinge residues; other site 264198013494 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 264198013495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198013496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198013497 dimerization interface [polypeptide binding]; other site 264198013498 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198013499 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013500 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198013501 CoA binding domain; Region: CoA_binding_2; pfam13380 264198013502 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198013503 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198013504 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013505 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198013506 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198013507 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198013508 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013509 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198013510 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 264198013511 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198013512 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013513 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198013514 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198013515 substrate binding site [chemical binding]; other site 264198013516 oxyanion hole (OAH) forming residues; other site 264198013517 trimer interface [polypeptide binding]; other site 264198013518 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013519 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198013520 active site 264198013521 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198013522 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198013523 active site 264198013524 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013525 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198013526 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198013527 eyelet of channel; other site 264198013528 trimer interface [polypeptide binding]; other site 264198013529 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 264198013530 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 264198013531 dimer interface [polypeptide binding]; other site 264198013532 NADP binding site [chemical binding]; other site 264198013533 catalytic residues [active] 264198013534 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198013535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013536 DNA-binding site [nucleotide binding]; DNA binding site 264198013537 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264198013538 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 264198013539 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 264198013540 active site 264198013541 tetramer interface [polypeptide binding]; other site 264198013542 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013543 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 264198013544 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 264198013545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198013546 catalytic residue [active] 264198013547 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264198013548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013549 DNA-binding site [nucleotide binding]; DNA binding site 264198013550 FCD domain; Region: FCD; pfam07729 264198013551 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 264198013552 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 264198013553 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 264198013554 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 264198013555 NAD(P) binding site [chemical binding]; other site 264198013556 catalytic residues [active] 264198013557 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264198013558 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 264198013559 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 264198013560 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 264198013561 glutamate dehydrogenase; Provisional; Region: PRK09414 264198013562 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198013563 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 264198013564 NAD(P) binding site [chemical binding]; other site 264198013565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198013566 dimer interface [polypeptide binding]; other site 264198013567 putative CheW interface [polypeptide binding]; other site 264198013568 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 264198013569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198013570 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264198013571 PAS fold; Region: PAS_4; pfam08448 264198013572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198013573 putative active site [active] 264198013574 heme pocket [chemical binding]; other site 264198013575 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198013576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198013577 Walker A motif; other site 264198013578 ATP binding site [chemical binding]; other site 264198013579 Walker B motif; other site 264198013580 arginine finger; other site 264198013581 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 264198013582 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 264198013583 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 264198013584 NAD binding site [chemical binding]; other site 264198013585 homotetramer interface [polypeptide binding]; other site 264198013586 homodimer interface [polypeptide binding]; other site 264198013587 substrate binding site [chemical binding]; other site 264198013588 active site 264198013589 Phasin protein; Region: Phasin_2; pfam09361 264198013590 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198013591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198013592 dimerization interface [polypeptide binding]; other site 264198013593 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198013594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198013595 dimer interface [polypeptide binding]; other site 264198013596 putative CheW interface [polypeptide binding]; other site 264198013597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 264198013598 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 264198013599 substrate binding site [chemical binding]; other site 264198013600 PaaX-like protein; Region: PaaX; pfam07848 264198013601 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 264198013602 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 264198013603 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 264198013604 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 264198013605 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 264198013606 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 264198013607 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 264198013608 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 264198013609 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 264198013610 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 264198013611 FAD binding pocket [chemical binding]; other site 264198013612 FAD binding motif [chemical binding]; other site 264198013613 phosphate binding motif [ion binding]; other site 264198013614 beta-alpha-beta structure motif; other site 264198013615 NAD(p) ribose binding residues [chemical binding]; other site 264198013616 NAD binding pocket [chemical binding]; other site 264198013617 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 264198013618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013619 catalytic loop [active] 264198013620 iron binding site [ion binding]; other site 264198013621 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 264198013622 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 264198013623 NADP binding site [chemical binding]; other site 264198013624 catalytic residues [active] 264198013625 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 264198013626 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 264198013627 active site 264198013628 AMP binding site [chemical binding]; other site 264198013629 homodimer interface [polypeptide binding]; other site 264198013630 acyl-activating enzyme (AAE) consensus motif; other site 264198013631 CoA binding site [chemical binding]; other site 264198013632 Protein of unknown function, DUF485; Region: DUF485; pfam04341 264198013633 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198013634 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198013635 Na binding site [ion binding]; other site 264198013636 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013637 thymidine phosphorylase; Provisional; Region: PRK04350 264198013638 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264198013639 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 264198013640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198013641 MarR family; Region: MarR; pfam01047 264198013642 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 264198013643 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264198013644 dimerization interface [polypeptide binding]; other site 264198013645 active site 264198013646 elongation factor G; Reviewed; Region: PRK13351 264198013647 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 264198013648 G1 box; other site 264198013649 putative GEF interaction site [polypeptide binding]; other site 264198013650 GTP/Mg2+ binding site [chemical binding]; other site 264198013651 Switch I region; other site 264198013652 G2 box; other site 264198013653 G3 box; other site 264198013654 Switch II region; other site 264198013655 G4 box; other site 264198013656 G5 box; other site 264198013657 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264198013658 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264198013659 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264198013660 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264198013661 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198013662 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198013663 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198013664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013665 DNA-binding site [nucleotide binding]; DNA binding site 264198013666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198013667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013668 homodimer interface [polypeptide binding]; other site 264198013669 catalytic residue [active] 264198013670 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 264198013671 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 264198013672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198013673 putative DNA binding site [nucleotide binding]; other site 264198013674 putative Zn2+ binding site [ion binding]; other site 264198013675 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013676 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 264198013677 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 264198013678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264198013679 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 264198013680 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198013681 metal ion-dependent adhesion site (MIDAS); other site 264198013682 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264198013683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013684 catalytic loop [active] 264198013685 iron binding site [ion binding]; other site 264198013686 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264198013687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013688 catalytic loop [active] 264198013689 iron binding site [ion binding]; other site 264198013690 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 264198013691 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 264198013692 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 264198013693 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 264198013694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013695 NAD(P) binding site [chemical binding]; other site 264198013696 catalytic residues [active] 264198013697 Domain of unknown function (DUF336); Region: DUF336; pfam03928 264198013698 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198013699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013700 catalytic loop [active] 264198013701 iron binding site [ion binding]; other site 264198013702 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 264198013703 FAD binding pocket [chemical binding]; other site 264198013704 FAD binding motif [chemical binding]; other site 264198013705 phosphate binding motif [ion binding]; other site 264198013706 beta-alpha-beta structure motif; other site 264198013707 NAD binding pocket [chemical binding]; other site 264198013708 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198013709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013710 DNA-binding site [nucleotide binding]; DNA binding site 264198013711 FCD domain; Region: FCD; pfam07729 264198013712 amidase; Provisional; Region: PRK06170 264198013713 Amidase; Region: Amidase; cl11426 264198013714 benzoate transport; Region: 2A0115; TIGR00895 264198013715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013716 putative substrate translocation pore; other site 264198013717 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198013718 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198013719 Autotransporter beta-domain; Region: Autotransporter; smart00869 264198013720 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 264198013721 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 264198013722 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198013723 PYR/PP interface [polypeptide binding]; other site 264198013724 dimer interface [polypeptide binding]; other site 264198013725 TPP binding site [chemical binding]; other site 264198013726 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198013727 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 264198013728 TPP-binding site; other site 264198013729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198013730 MarR family; Region: MarR_2; cl17246 264198013731 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 264198013732 inter-subunit interface; other site 264198013733 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198013734 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198013735 iron-sulfur cluster [ion binding]; other site 264198013736 [2Fe-2S] cluster binding site [ion binding]; other site 264198013737 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 264198013738 putative alpha subunit interface [polypeptide binding]; other site 264198013739 putative active site [active] 264198013740 putative substrate binding site [chemical binding]; other site 264198013741 Fe binding site [ion binding]; other site 264198013742 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198013743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198013744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198013745 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198013746 [2Fe-2S] cluster binding site [ion binding]; other site 264198013747 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198013748 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198013749 TM-ABC transporter signature motif; other site 264198013750 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198013751 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198013752 TM-ABC transporter signature motif; other site 264198013753 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198013754 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198013755 Walker A/P-loop; other site 264198013756 ATP binding site [chemical binding]; other site 264198013757 Q-loop/lid; other site 264198013758 ABC transporter signature motif; other site 264198013759 Walker B; other site 264198013760 D-loop; other site 264198013761 H-loop/switch region; other site 264198013762 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198013763 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198013764 Walker A/P-loop; other site 264198013765 ATP binding site [chemical binding]; other site 264198013766 Q-loop/lid; other site 264198013767 ABC transporter signature motif; other site 264198013768 Walker B; other site 264198013769 D-loop; other site 264198013770 H-loop/switch region; other site 264198013771 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198013772 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198013773 putative ligand binding site [chemical binding]; other site 264198013774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013775 putative substrate translocation pore; other site 264198013776 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198013777 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 264198013778 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198013779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198013780 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198013781 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 264198013782 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 264198013783 Isochorismatase family; Region: Isochorismatase; pfam00857 264198013784 catalytic triad [active] 264198013785 substrate binding site [chemical binding]; other site 264198013786 domain interfaces; other site 264198013787 conserved cis-peptide bond; other site 264198013788 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198013789 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198013790 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198013791 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 264198013792 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198013793 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013794 catalytic loop [active] 264198013795 iron binding site [ion binding]; other site 264198013796 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198013797 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 264198013798 putative hydrophobic ligand binding site [chemical binding]; other site 264198013799 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198013800 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 264198013801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198013802 DNA binding residues [nucleotide binding] 264198013803 Uncharacterized conserved protein [Function unknown]; Region: COG3391 264198013804 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198013805 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198013806 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198013807 Domain of unknown function (DUF305); Region: DUF305; cl17794 264198013808 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013809 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013810 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198013811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013812 DNA-binding site [nucleotide binding]; DNA binding site 264198013813 UTRA domain; Region: UTRA; pfam07702 264198013814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198013815 active site 264198013816 Outer membrane efflux protein; Region: OEP; pfam02321 264198013817 Outer membrane efflux protein; Region: OEP; pfam02321 264198013818 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198013819 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198013820 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198013821 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264198013822 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198013823 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198013824 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198013825 Autotransporter beta-domain; Region: Autotransporter; pfam03797 264198013826 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198013827 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 264198013828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198013829 dimerization interface [polypeptide binding]; other site 264198013830 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198013831 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198013832 dimer interface [polypeptide binding]; other site 264198013833 putative CheW interface [polypeptide binding]; other site 264198013834 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 264198013835 Protein of unknown function (DUF2880); Region: DUF2880; pfam11082 264198013836 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 264198013837 Predicted small secreted protein [Function unknown]; Region: COG5510 264198013838 EamA-like transporter family; Region: EamA; pfam00892 264198013839 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264198013840 homotrimer interaction site [polypeptide binding]; other site 264198013841 putative active site [active] 264198013842 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013843 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264198013844 active sites [active] 264198013845 argininosuccinate lyase; Provisional; Region: PRK00855 264198013846 tetramer interface [polypeptide binding]; other site 264198013847 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 264198013848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198013849 The C-terminal substrate-domain of LysR-type transcriptional regulator, NocR, involved in the catabolism of nopaline, contains the type 2 periplasmic binding fold; Region: PBP2_NocR; cd08458 264198013850 putative dimerization interface [polypeptide binding]; other site 264198013851 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 264198013852 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198013853 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198013854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198013855 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198013856 putative effector binding pocket; other site 264198013857 dimerization interface [polypeptide binding]; other site 264198013858 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198013859 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198013861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013862 active site 264198013863 choline dehydrogenase; Validated; Region: PRK02106 264198013864 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198013865 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 264198013866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198013867 SCP-2 sterol transfer family; Region: SCP2; pfam02036 264198013868 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198013869 CoA binding domain; Region: CoA_binding_2; pfam13380 264198013870 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198013871 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198013872 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198013873 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198013874 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198013875 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198013876 active site 264198013877 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264198013878 Winged helix-turn helix; Region: HTH_29; pfam13551 264198013879 Homeodomain-like domain; Region: HTH_32; pfam13565 264198013880 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198013881 AAA ATPase domain; Region: AAA_16; pfam13191 264198013882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198013883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013884 DNA binding residues [nucleotide binding] 264198013885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198013886 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 264198013887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013888 NAD(P) binding site [chemical binding]; other site 264198013889 active site 264198013890 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198013891 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198013892 FAD binding site [chemical binding]; other site 264198013893 substrate binding site [chemical binding]; other site 264198013894 catalytic base [active] 264198013895 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198013896 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198013897 active site 264198013898 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198013899 putative active site [active] 264198013900 putative catalytic site [active] 264198013901 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198013902 classical (c) SDRs; Region: SDR_c; cd05233 264198013903 NAD(P) binding site [chemical binding]; other site 264198013904 active site 264198013905 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198013906 classical (c) SDRs; Region: SDR_c; cd05233 264198013907 NAD(P) binding site [chemical binding]; other site 264198013908 active site 264198013909 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198013910 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198013911 NADP binding site [chemical binding]; other site 264198013912 dimer interface [polypeptide binding]; other site 264198013913 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013914 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198013915 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198013916 Ligand Binding Site [chemical binding]; other site 264198013917 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 264198013918 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198013919 AAA ATPase domain; Region: AAA_16; pfam13191 264198013920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013921 DNA binding residues [nucleotide binding] 264198013922 dimerization interface [polypeptide binding]; other site 264198013923 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 264198013924 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 264198013925 phosphate binding site [ion binding]; other site 264198013926 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198013927 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198013928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013929 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198013930 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198013931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198013932 classical (c) SDRs; Region: SDR_c; cd05233 264198013933 NAD(P) binding site [chemical binding]; other site 264198013934 active site 264198013935 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198013936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198013937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013938 EthD domain; Region: EthD; pfam07110 264198013939 EthD domain; Region: EthD; cl17553 264198013940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013941 NAD(P) binding site [chemical binding]; other site 264198013942 active site 264198013943 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 264198013944 Prostaglandin dehydrogenases; Region: PGDH; cd05288 264198013945 NAD(P) binding site [chemical binding]; other site 264198013946 substrate binding site [chemical binding]; other site 264198013947 dimer interface [polypeptide binding]; other site 264198013948 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198013949 Beta-lactamase; Region: Beta-lactamase; pfam00144 264198013950 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013951 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198013952 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198013953 trimer interface [polypeptide binding]; other site 264198013954 eyelet of channel; other site 264198013955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198013956 extended (e) SDRs; Region: SDR_e; cd08946 264198013957 NAD(P) binding site [chemical binding]; other site 264198013958 active site 264198013959 substrate binding site [chemical binding]; other site 264198013960 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198013961 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198013962 FAD binding site [chemical binding]; other site 264198013963 substrate binding site [chemical binding]; other site 264198013964 catalytic base [active] 264198013965 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198013966 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013967 NAD binding site [chemical binding]; other site 264198013968 catalytic residues [active] 264198013969 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013970 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198013971 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198013972 trimer interface [polypeptide binding]; other site 264198013973 eyelet of channel; other site 264198013974 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198013975 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013976 Phasin protein; Region: Phasin_2; pfam09361 264198013977 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 264198013978 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198013979 NAD(P) binding site [chemical binding]; other site 264198013980 homotetramer interface [polypeptide binding]; other site 264198013981 homodimer interface [polypeptide binding]; other site 264198013982 active site 264198013983 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013984 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013985 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198013986 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198013987 active site 264198013988 oxalacetate binding site [chemical binding]; other site 264198013989 citrylCoA binding site [chemical binding]; other site 264198013990 coenzyme A binding site [chemical binding]; other site 264198013991 catalytic triad [active] 264198013992 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198013993 CoA binding domain; Region: CoA_binding_2; pfam13380 264198013994 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198013995 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198013996 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198013997 active site 2 [active] 264198013998 active site 1 [active] 264198013999 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014000 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198014001 active site 264198014002 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198014003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014004 NAD(P) binding site [chemical binding]; other site 264198014005 active site 264198014006 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014007 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 264198014008 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198014009 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198014010 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 264198014011 substrate binding site [chemical binding]; other site 264198014012 oxyanion hole (OAH) forming residues; other site 264198014013 trimer interface [polypeptide binding]; other site 264198014014 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198014015 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198014016 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198014017 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014018 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014019 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014020 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014021 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014022 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 264198014023 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 264198014024 NADP binding site [chemical binding]; other site 264198014025 dimer interface [polypeptide binding]; other site 264198014026 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014027 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014028 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198014029 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014030 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198014031 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014034 active site 264198014035 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198014036 CoA binding domain; Region: CoA_binding_2; pfam13380 264198014037 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198014038 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198014039 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014040 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198014041 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198014042 thiolase; Provisional; Region: PRK06158 264198014043 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198014044 active site 264198014045 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198014046 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198014047 putative ligand binding site [chemical binding]; other site 264198014048 Putative cyclase; Region: Cyclase; pfam04199 264198014049 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014050 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198014051 PAS domain; Region: PAS_9; pfam13426 264198014052 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198014053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198014054 Walker A motif; other site 264198014055 ATP binding site [chemical binding]; other site 264198014056 Walker B motif; other site 264198014057 arginine finger; other site 264198014058 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198014059 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264198014060 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264198014061 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264198014062 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198014063 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198014064 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198014065 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 264198014066 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 264198014067 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198014068 carboxyltransferase (CT) interaction site; other site 264198014069 biotinylation site [posttranslational modification]; other site 264198014070 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 264198014071 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264198014072 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014073 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014074 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014075 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014076 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014077 ATP-dependent DNA ligase; Validated; Region: PRK09247 264198014078 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 264198014079 active site 264198014080 DNA binding site [nucleotide binding] 264198014081 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 264198014082 DNA binding site [nucleotide binding] 264198014083 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 264198014084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198014085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198014087 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198014088 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198014089 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198014090 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014091 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264198014092 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 264198014093 transmembrane helices; other site 264198014094 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198014095 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198014096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014097 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198014098 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 264198014099 hypothetical protein; Provisional; Region: PRK09040 264198014100 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198014101 ligand binding site [chemical binding]; other site 264198014102 Domain of unknown function (DUF802); Region: DUF802; pfam05650 264198014103 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 264198014104 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 264198014105 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264198014106 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 264198014107 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198014108 catalytic residues [active] 264198014109 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198014110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014111 active site 264198014112 phosphorylation site [posttranslational modification] 264198014113 intermolecular recognition site; other site 264198014114 dimerization interface [polypeptide binding]; other site 264198014115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198014116 DNA binding site [nucleotide binding] 264198014117 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264198014118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014119 dimer interface [polypeptide binding]; other site 264198014120 phosphorylation site [posttranslational modification] 264198014121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014122 ATP binding site [chemical binding]; other site 264198014123 Mg2+ binding site [ion binding]; other site 264198014124 G-X-G motif; other site 264198014125 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 264198014126 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198014127 catalytic residues [active] 264198014128 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 264198014129 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 264198014130 putative NAD(P) binding site [chemical binding]; other site 264198014131 dimer interface [polypeptide binding]; other site 264198014132 GYD domain; Region: GYD; pfam08734 264198014133 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198014134 MarR family; Region: MarR_2; pfam12802 264198014135 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 264198014136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014137 NAD(P) binding site [chemical binding]; other site 264198014138 active site 264198014139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198014140 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264198014141 substrate binding site [chemical binding]; other site 264198014142 oxyanion hole (OAH) forming residues; other site 264198014143 trimer interface [polypeptide binding]; other site 264198014144 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 264198014145 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014146 active site 264198014147 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 264198014148 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 264198014149 acyl-activating enzyme (AAE) consensus motif; other site 264198014150 putative AMP binding site [chemical binding]; other site 264198014151 putative active site [active] 264198014152 putative CoA binding site [chemical binding]; other site 264198014153 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198014154 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264198014155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198014157 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 264198014158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198014159 sequence-specific DNA binding site [nucleotide binding]; other site 264198014160 salt bridge; other site 264198014161 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 264198014162 fumarylacetoacetase; Region: PLN02856 264198014163 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 264198014164 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198014165 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 264198014166 putative active site 1 [active] 264198014167 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 264198014168 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 264198014169 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264198014170 dimer interface [polypeptide binding]; other site 264198014171 active site 264198014172 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 264198014173 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 264198014174 NodB motif; other site 264198014175 putative active site [active] 264198014176 putative catalytic site [active] 264198014177 putative Zn binding site [ion binding]; other site 264198014178 Predicted exporter [General function prediction only]; Region: COG4258 264198014179 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198014180 putative acyl-acceptor binding pocket; other site 264198014181 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198014182 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198014183 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198014184 acyl-activating enzyme (AAE) consensus motif; other site 264198014185 acyl-activating enzyme (AAE) consensus motif; other site 264198014186 AMP binding site [chemical binding]; other site 264198014187 active site 264198014188 CoA binding site [chemical binding]; other site 264198014189 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 264198014190 active site 2 [active] 264198014191 dimer interface [polypeptide binding]; other site 264198014192 active site 1 [active] 264198014193 Predicted membrane protein [Function unknown]; Region: COG4648 264198014194 acyl carrier protein; Provisional; Region: PRK09184 264198014195 short chain dehydrogenase; Provisional; Region: PRK09134 264198014196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014197 NAD(P) binding site [chemical binding]; other site 264198014198 active site 264198014199 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264198014200 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264198014201 Ligand binding site; other site 264198014202 Putative Catalytic site; other site 264198014203 DXD motif; other site 264198014204 Cupin domain; Region: Cupin_2; cl17218 264198014205 benzoate transport; Region: 2A0115; TIGR00895 264198014206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014207 putative substrate translocation pore; other site 264198014208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014209 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198014210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014211 DNA-binding site [nucleotide binding]; DNA binding site 264198014212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198014213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198014214 homodimer interface [polypeptide binding]; other site 264198014215 catalytic residue [active] 264198014216 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 264198014217 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198014218 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198014219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 264198014220 Peptidase M15; Region: Peptidase_M15_3; cl01194 264198014221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 264198014222 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 264198014223 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264198014224 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198014225 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198014226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198014227 non-specific DNA binding site [nucleotide binding]; other site 264198014228 salt bridge; other site 264198014229 sequence-specific DNA binding site [nucleotide binding]; other site 264198014230 HipA N-terminal domain; Region: Couple_hipA; pfam13657 264198014231 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 264198014232 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264198014233 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264198014234 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014235 dihydroxy-acid dehydratase; Validated; Region: PRK06131 264198014236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198014237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014238 DNA-binding site [nucleotide binding]; DNA binding site 264198014239 FCD domain; Region: FCD; pfam07729 264198014240 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198014241 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198014242 conserved cys residue [active] 264198014243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198014247 putative substrate translocation pore; other site 264198014248 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198014249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014251 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198014252 putative dimerization interface [polypeptide binding]; other site 264198014253 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198014254 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 264198014255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198014256 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198014257 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 264198014258 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264198014259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014260 active site 264198014261 phosphorylation site [posttranslational modification] 264198014262 intermolecular recognition site; other site 264198014263 dimerization interface [polypeptide binding]; other site 264198014264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198014265 DNA binding site [nucleotide binding] 264198014266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198014267 dimerization interface [polypeptide binding]; other site 264198014268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014269 dimer interface [polypeptide binding]; other site 264198014270 phosphorylation site [posttranslational modification] 264198014271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014272 ATP binding site [chemical binding]; other site 264198014273 Mg2+ binding site [ion binding]; other site 264198014274 G-X-G motif; other site 264198014275 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264198014276 dimer interface [polypeptide binding]; other site 264198014277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014280 dimerization interface [polypeptide binding]; other site 264198014281 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 264198014282 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264198014283 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014284 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 264198014285 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 264198014286 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198014287 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198014288 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264198014289 Heavy-metal-associated domain; Region: HMA; pfam00403 264198014290 metal-binding site [ion binding] 264198014291 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198014292 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264198014293 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 264198014294 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264198014295 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 264198014296 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264198014297 NAD binding site [chemical binding]; other site 264198014298 substrate binding site [chemical binding]; other site 264198014299 active site 264198014300 putative formyltransferase; Provisional; Region: PRK06988 264198014301 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 264198014302 active site 264198014303 substrate binding site [chemical binding]; other site 264198014304 cosubstrate binding site; other site 264198014305 catalytic site [active] 264198014306 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 264198014307 active site 264198014308 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264198014309 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264198014310 Ligand binding site; other site 264198014311 Putative Catalytic site; other site 264198014312 DXD motif; other site 264198014313 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264198014314 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264198014315 inhibitor-cofactor binding pocket; inhibition site 264198014316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198014317 catalytic residue [active] 264198014318 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 264198014319 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 264198014320 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198014321 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 264198014322 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198014323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198014324 substrate binding pocket [chemical binding]; other site 264198014325 membrane-bound complex binding site; other site 264198014326 hinge residues; other site 264198014327 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 264198014328 hypothetical protein; Validated; Region: PRK07198 264198014329 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 264198014330 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264198014331 dimerization interface [polypeptide binding]; other site 264198014332 active site 264198014333 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 264198014334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198014335 active site 264198014336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198014337 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 264198014338 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 264198014339 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264198014340 putative ligand binding site [chemical binding]; other site 264198014341 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264198014342 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264198014343 Walker A/P-loop; other site 264198014344 ATP binding site [chemical binding]; other site 264198014345 Q-loop/lid; other site 264198014346 ABC transporter signature motif; other site 264198014347 Walker B; other site 264198014348 D-loop; other site 264198014349 H-loop/switch region; other site 264198014350 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264198014351 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 264198014352 TM-ABC transporter signature motif; other site 264198014353 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198014354 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264198014355 TM-ABC transporter signature motif; other site 264198014356 cytosine deaminase; Validated; Region: PRK07572 264198014357 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 264198014358 active site 264198014359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198014360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198014361 metal binding site [ion binding]; metal-binding site 264198014362 active site 264198014363 I-site; other site 264198014364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264198014365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198014366 Coenzyme A binding pocket [chemical binding]; other site 264198014367 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 264198014368 S-formylglutathione hydrolase; Region: PLN02442 264198014369 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 264198014370 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 264198014371 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 264198014372 substrate binding site [chemical binding]; other site 264198014373 catalytic Zn binding site [ion binding]; other site 264198014374 NAD binding site [chemical binding]; other site 264198014375 structural Zn binding site [ion binding]; other site 264198014376 dimer interface [polypeptide binding]; other site 264198014377 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 264198014378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198014379 dimer interface [polypeptide binding]; other site 264198014380 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 264198014381 putative CheW interface [polypeptide binding]; other site 264198014382 TLC ATP/ADP transporter; Region: TLC; cl03940 264198014383 TLC ATP/ADP transporter; Region: TLC; cl03940 264198014384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198014385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198014386 active site 264198014387 catalytic tetrad [active] 264198014388 amino acid transporter; Region: 2A0306; TIGR00909 264198014389 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264198014390 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264198014391 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 264198014392 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198014393 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198014394 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198014395 TM-ABC transporter signature motif; other site 264198014396 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 264198014397 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198014398 TM-ABC transporter signature motif; other site 264198014399 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198014400 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 264198014401 Walker A/P-loop; other site 264198014402 ATP binding site [chemical binding]; other site 264198014403 Q-loop/lid; other site 264198014404 ABC transporter signature motif; other site 264198014405 Walker B; other site 264198014406 D-loop; other site 264198014407 H-loop/switch region; other site 264198014408 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198014409 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 264198014410 Walker A/P-loop; other site 264198014411 ATP binding site [chemical binding]; other site 264198014412 Q-loop/lid; other site 264198014413 ABC transporter signature motif; other site 264198014414 Walker B; other site 264198014415 D-loop; other site 264198014416 H-loop/switch region; other site 264198014417 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 264198014418 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264198014419 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198014420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198014421 S-adenosylmethionine binding site [chemical binding]; other site 264198014422 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 264198014423 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264198014424 active site 264198014425 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264198014426 active site 264198014427 catalytic residues [active] 264198014428 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264198014429 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198014430 putative acyl-acceptor binding pocket; other site 264198014431 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264198014432 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 264198014433 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198014434 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264198014435 GntP family permease; Region: GntP_permease; pfam02447 264198014436 fructuronate transporter; Provisional; Region: PRK10034; cl15264 264198014437 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198014438 homotrimer interaction site [polypeptide binding]; other site 264198014439 putative active site [active] 264198014440 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 264198014441 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 264198014442 active site 264198014443 putative substrate binding pocket [chemical binding]; other site 264198014444 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198014445 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198014446 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198014447 putative active site [active] 264198014448 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 264198014449 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 264198014450 dimer interface [polypeptide binding]; other site 264198014451 active site 264198014452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198014453 substrate binding site [chemical binding]; other site 264198014454 catalytic residue [active] 264198014455 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198014456 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264198014457 substrate binding site [chemical binding]; other site 264198014458 ATP binding site [chemical binding]; other site 264198014459 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 264198014460 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 264198014461 active site 264198014462 intersubunit interface [polypeptide binding]; other site 264198014463 catalytic residue [active] 264198014464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198014465 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198014466 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264198014467 Domain of unknown function DUF21; Region: DUF21; pfam01595 264198014468 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264198014469 Transporter associated domain; Region: CorC_HlyC; smart01091 264198014470 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198014471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198014472 non-specific DNA binding site [nucleotide binding]; other site 264198014473 salt bridge; other site 264198014474 sequence-specific DNA binding site [nucleotide binding]; other site 264198014475 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 264198014476 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 264198014477 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 264198014478 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 264198014479 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 264198014480 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 264198014481 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198014482 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 264198014483 Ligand binding site; other site 264198014484 DXD motif; other site 264198014485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014486 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 264198014487 putative substrate translocation pore; other site 264198014488 mechanosensitive channel MscS; Provisional; Region: PRK10334 264198014489 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198014490 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 264198014491 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198014492 IHF dimer interface [polypeptide binding]; other site 264198014493 IHF - DNA interface [nucleotide binding]; other site 264198014494 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264198014495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 264198014496 CreA protein; Region: CreA; pfam05981 264198014497 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198014498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198014499 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 264198014500 acyl-activating enzyme (AAE) consensus motif; other site 264198014501 putative AMP binding site [chemical binding]; other site 264198014502 putative active site [active] 264198014503 putative CoA binding site [chemical binding]; other site 264198014504 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198014505 classical (c) SDRs; Region: SDR_c; cd05233 264198014506 NAD(P) binding site [chemical binding]; other site 264198014507 active site 264198014508 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 264198014509 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198014510 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198014511 ligand binding site [chemical binding]; other site 264198014512 flexible hinge region; other site 264198014513 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 264198014514 Predicted membrane protein [Function unknown]; Region: COG4539 264198014515 sensor protein PhoQ; Provisional; Region: PRK10815 264198014516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014517 ATP binding site [chemical binding]; other site 264198014518 Mg2+ binding site [ion binding]; other site 264198014519 G-X-G motif; other site 264198014520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198014521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014522 active site 264198014523 dimerization interface [polypeptide binding]; other site 264198014524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198014525 DNA binding site [nucleotide binding] 264198014526 IHF dimer interface [polypeptide binding]; other site 264198014527 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 264198014528 IHF - DNA interface [nucleotide binding]; other site 264198014529 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 264198014530 putative substrate binding pocket [chemical binding]; other site 264198014531 trimer interface [polypeptide binding]; other site 264198014532 MgtC family; Region: MgtC; pfam02308 264198014533 Arginase family; Region: Arginase; cd09989 264198014534 active site 264198014535 Mn binding site [ion binding]; other site 264198014536 oligomer interface [polypeptide binding]; other site 264198014537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198014538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014539 active site 264198014540 phosphorylation site [posttranslational modification] 264198014541 intermolecular recognition site; other site 264198014542 dimerization interface [polypeptide binding]; other site 264198014543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198014544 DNA binding site [nucleotide binding] 264198014545 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 264198014546 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198014547 putative active site [active] 264198014548 catalytic site [active] 264198014549 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 264198014550 putative active site [active] 264198014551 catalytic site [active] 264198014552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198014554 WHG domain; Region: WHG; pfam13305 264198014555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198014556 Zn2+ binding site [ion binding]; other site 264198014557 Mg2+ binding site [ion binding]; other site 264198014558 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264198014559 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 264198014560 FMN binding site [chemical binding]; other site 264198014561 active site 264198014562 substrate binding site [chemical binding]; other site 264198014563 catalytic residue [active] 264198014564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198014565 dimerization interface [polypeptide binding]; other site 264198014566 putative DNA binding site [nucleotide binding]; other site 264198014567 putative Zn2+ binding site [ion binding]; other site 264198014568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198014569 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198014570 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198014571 catalytic residues [active] 264198014572 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 264198014573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014574 active site 264198014575 phosphorylation site [posttranslational modification] 264198014576 intermolecular recognition site; other site 264198014577 dimerization interface [polypeptide binding]; other site 264198014578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198014579 Zn2+ binding site [ion binding]; other site 264198014580 Mg2+ binding site [ion binding]; other site 264198014581 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198014582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198014583 putative active site [active] 264198014584 heme pocket [chemical binding]; other site 264198014585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014586 dimer interface [polypeptide binding]; other site 264198014587 phosphorylation site [posttranslational modification] 264198014588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014589 ATP binding site [chemical binding]; other site 264198014590 Mg2+ binding site [ion binding]; other site 264198014591 G-X-G motif; other site 264198014592 Response regulator receiver domain; Region: Response_reg; pfam00072 264198014593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014594 active site 264198014595 phosphorylation site [posttranslational modification] 264198014596 intermolecular recognition site; other site 264198014597 dimerization interface [polypeptide binding]; other site 264198014598 Response regulator receiver domain; Region: Response_reg; pfam00072 264198014599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014600 active site 264198014601 phosphorylation site [posttranslational modification] 264198014602 intermolecular recognition site; other site 264198014603 dimerization interface [polypeptide binding]; other site 264198014604 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198014605 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 264198014606 dimer interface [polypeptide binding]; other site 264198014607 ligand binding site [chemical binding]; other site 264198014608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014609 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198014610 amidase; Provisional; Region: PRK07486 264198014611 Amidase; Region: Amidase; pfam01425 264198014612 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264198014613 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198014614 NAD(P) binding site [chemical binding]; other site 264198014615 catalytic residues [active] 264198014616 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198014617 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 264198014618 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198014619 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198014620 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 264198014621 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198014622 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 264198014623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198014624 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198014625 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198014626 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264198014627 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198014628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014630 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 264198014631 putative dimerization interface [polypeptide binding]; other site 264198014632 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 264198014633 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 264198014634 putative active site [active] 264198014635 Cupin domain; Region: Cupin_2; cl17218 264198014636 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198014637 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198014638 Protein export membrane protein; Region: SecD_SecF; cl14618 264198014639 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 264198014640 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198014641 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198014642 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 264198014643 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 264198014644 putative molybdopterin cofactor binding site [chemical binding]; other site 264198014645 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 264198014646 putative molybdopterin cofactor binding site; other site 264198014647 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 264198014648 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264198014649 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264198014650 dimer interface [polypeptide binding]; other site 264198014651 putative functional site; other site 264198014652 putative MPT binding site; other site 264198014653 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198014654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014655 DNA-binding site [nucleotide binding]; DNA binding site 264198014656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198014657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198014658 homodimer interface [polypeptide binding]; other site 264198014659 catalytic residue [active] 264198014660 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 264198014661 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 264198014662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198014663 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198014664 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 264198014665 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198014666 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264198014667 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 264198014668 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264198014669 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264198014670 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 264198014671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198014673 Coenzyme A binding pocket [chemical binding]; other site 264198014674 Uncharacterized conserved protein [Function unknown]; Region: COG5649 264198014675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198014676 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 264198014677 putative active site [active] 264198014678 heme pocket [chemical binding]; other site 264198014679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198014680 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198014681 putative active site [active] 264198014682 heme pocket [chemical binding]; other site 264198014683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014684 dimer interface [polypeptide binding]; other site 264198014685 phosphorylation site [posttranslational modification] 264198014686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014687 ATP binding site [chemical binding]; other site 264198014688 Mg2+ binding site [ion binding]; other site 264198014689 G-X-G motif; other site 264198014690 Response regulator receiver domain; Region: Response_reg; pfam00072 264198014691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014692 active site 264198014693 phosphorylation site [posttranslational modification] 264198014694 intermolecular recognition site; other site 264198014695 dimerization interface [polypeptide binding]; other site 264198014696 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264198014697 tartrate dehydrogenase; Region: TTC; TIGR02089 264198014698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198014700 PAS domain; Region: PAS_9; pfam13426 264198014701 putative active site [active] 264198014702 heme pocket [chemical binding]; other site 264198014703 drug efflux system protein MdtG; Provisional; Region: PRK09874 264198014704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014705 putative substrate translocation pore; other site 264198014706 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198014707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014708 DNA-binding site [nucleotide binding]; DNA binding site 264198014709 FCD domain; Region: FCD; pfam07729 264198014710 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 264198014711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014712 D-galactonate transporter; Region: 2A0114; TIGR00893 264198014713 putative substrate translocation pore; other site 264198014714 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198014715 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 264198014716 active site pocket [active] 264198014717 Cupin domain; Region: Cupin_2; pfam07883 264198014718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198014719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014721 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198014722 putative effector binding pocket; other site 264198014723 dimerization interface [polypeptide binding]; other site 264198014724 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 264198014725 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198014726 NAD(P) binding site [chemical binding]; other site 264198014727 homotetramer interface [polypeptide binding]; other site 264198014728 homodimer interface [polypeptide binding]; other site 264198014729 active site 264198014730 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198014731 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198014732 active site 264198014733 dimer interface [polypeptide binding]; other site 264198014734 metal binding site [ion binding]; metal-binding site 264198014735 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198014736 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198014737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014739 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198014740 putative effector binding pocket; other site 264198014741 dimerization interface [polypeptide binding]; other site 264198014742 hypothetical protein; Provisional; Region: PRK08204 264198014743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014744 active site 264198014745 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264198014746 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 264198014747 Walker A/P-loop; other site 264198014748 ATP binding site [chemical binding]; other site 264198014749 Q-loop/lid; other site 264198014750 ABC transporter signature motif; other site 264198014751 Walker B; other site 264198014752 D-loop; other site 264198014753 H-loop/switch region; other site 264198014754 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 264198014755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198014756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264198014757 TM-ABC transporter signature motif; other site 264198014758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 264198014759 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264198014760 TM-ABC transporter signature motif; other site 264198014761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264198014762 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 264198014763 ligand binding site [chemical binding]; other site 264198014764 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 264198014765 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198014766 dimer interface [polypeptide binding]; other site 264198014767 active site 264198014768 YciI-like protein; Reviewed; Region: PRK12863 264198014769 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 264198014770 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198014771 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 264198014772 putative ligand binding site [chemical binding]; other site 264198014773 putative NAD binding site [chemical binding]; other site 264198014774 catalytic site [active] 264198014775 Predicted permease [General function prediction only]; Region: COG2985 264198014776 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198014777 TrkA-C domain; Region: TrkA_C; pfam02080 264198014778 TrkA-C domain; Region: TrkA_C; pfam02080 264198014779 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198014780 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014781 amidase; Provisional; Region: PRK07486 264198014782 Amidase; Region: Amidase; cl11426 264198014783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014785 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 264198014786 putative dimerization interface [polypeptide binding]; other site 264198014787 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 264198014788 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198014789 putative metal binding site [ion binding]; other site 264198014790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198014792 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 264198014793 putative dimerization interface [polypeptide binding]; other site 264198014794 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198014795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014796 DNA-binding site [nucleotide binding]; DNA binding site 264198014797 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198014798 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 264198014799 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 264198014800 putative active site [active] 264198014801 putative catalytic site [active] 264198014802 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198014803 active site 2 [active] 264198014804 active site 1 [active] 264198014805 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014806 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014807 active site 264198014808 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014809 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014810 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198014811 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198014812 active site 264198014813 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198014814 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198014815 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014816 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198014817 active site 264198014818 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 264198014819 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198014820 acyl-activating enzyme (AAE) consensus motif; other site 264198014821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198014822 acyl-activating enzyme (AAE) consensus motif; other site 264198014823 AMP binding site [chemical binding]; other site 264198014824 active site 264198014825 CoA binding site [chemical binding]; other site 264198014826 methionine sulfoxide reductase A; Provisional; Region: PRK14054 264198014827 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198014828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014829 DNA-binding site [nucleotide binding]; DNA binding site 264198014830 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198014831 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198014832 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198014833 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198014834 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198014835 NAD binding site [chemical binding]; other site 264198014836 catalytic residues [active] 264198014837 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198014838 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 264198014839 Trp docking motif [polypeptide binding]; other site 264198014840 cytochrome domain interface [polypeptide binding]; other site 264198014841 active site 264198014842 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198014843 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014844 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014845 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014846 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198014847 AAA ATPase domain; Region: AAA_16; pfam13191 264198014848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198014849 DNA binding residues [nucleotide binding] 264198014850 dimerization interface [polypeptide binding]; other site 264198014851 feruloyl-CoA synthase; Reviewed; Region: PRK08180 264198014852 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 264198014853 acyl-activating enzyme (AAE) consensus motif; other site 264198014854 putative AMP binding site [chemical binding]; other site 264198014855 putative active site [active] 264198014856 putative CoA binding site [chemical binding]; other site 264198014857 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014858 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014859 active site 264198014860 lipid-transfer protein; Provisional; Region: PRK08256 264198014861 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198014862 active site 264198014863 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 264198014864 active site 264198014865 catalytic site [active] 264198014866 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 264198014867 active site 264198014868 catalytic site [active] 264198014869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198014870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014871 NAD(P) binding site [chemical binding]; other site 264198014872 active site 264198014873 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198014874 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198014875 trimer interface [polypeptide binding]; other site 264198014876 eyelet of channel; other site 264198014877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198014878 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198014879 Walker A motif; other site 264198014880 ATP binding site [chemical binding]; other site 264198014881 Walker B motif; other site 264198014882 arginine finger; other site 264198014883 Predicted esterase [General function prediction only]; Region: COG0400 264198014884 putative hydrolase; Provisional; Region: PRK11460 264198014885 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 264198014886 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 264198014887 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 264198014888 Walker A/P-loop; other site 264198014889 ATP binding site [chemical binding]; other site 264198014890 Q-loop/lid; other site 264198014891 ABC transporter signature motif; other site 264198014892 Walker B; other site 264198014893 D-loop; other site 264198014894 H-loop/switch region; other site 264198014895 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 264198014896 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264198014897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198014898 dimer interface [polypeptide binding]; other site 264198014899 conserved gate region; other site 264198014900 putative PBP binding loops; other site 264198014901 ABC-ATPase subunit interface; other site 264198014902 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 264198014903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198014904 Coenzyme A binding pocket [chemical binding]; other site 264198014905 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 264198014906 Guanylate kinase; Region: Guanylate_kin; pfam00625 264198014907 active site 264198014908 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 264198014909 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 264198014910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014912 active site 264198014913 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 264198014914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014915 DNA-binding site [nucleotide binding]; DNA binding site 264198014916 UTRA domain; Region: UTRA; pfam07702 264198014917 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 264198014918 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 264198014919 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 264198014920 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 264198014921 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 264198014922 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264198014923 Walker A/P-loop; other site 264198014924 ATP binding site [chemical binding]; other site 264198014925 Q-loop/lid; other site 264198014926 ABC transporter signature motif; other site 264198014927 Walker B; other site 264198014928 D-loop; other site 264198014929 H-loop/switch region; other site 264198014930 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198014931 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 264198014932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198014933 Walker A/P-loop; other site 264198014934 ATP binding site [chemical binding]; other site 264198014935 Q-loop/lid; other site 264198014936 ABC transporter signature motif; other site 264198014937 Walker B; other site 264198014938 D-loop; other site 264198014939 H-loop/switch region; other site 264198014940 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 264198014941 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014943 active site 264198014944 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 264198014945 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264198014946 active site 264198014947 metal binding site [ion binding]; metal-binding site 264198014948 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264198014949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198014950 Walker A/P-loop; other site 264198014951 ATP binding site [chemical binding]; other site 264198014952 Q-loop/lid; other site 264198014953 ABC transporter signature motif; other site 264198014954 Walker B; other site 264198014955 D-loop; other site 264198014956 H-loop/switch region; other site 264198014957 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198014958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014959 DNA-binding site [nucleotide binding]; DNA binding site 264198014960 UTRA domain; Region: UTRA; pfam07702 264198014961 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 264198014962 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 264198014963 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 264198014964 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 264198014965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 264198014966 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 264198014967 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198014968 tetramerization interface [polypeptide binding]; other site 264198014969 NAD(P) binding site [chemical binding]; other site 264198014970 catalytic residues [active] 264198014971 transcriptional activator FlhC; Provisional; Region: PRK12722 264198014972 transcriptional activator FlhD; Provisional; Region: PRK02909 264198014973 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198014974 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198014975 ligand binding site [chemical binding]; other site 264198014976 flexible hinge region; other site 264198014977 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198014978 putative switch regulator; other site 264198014979 non-specific DNA interactions [nucleotide binding]; other site 264198014980 DNA binding site [nucleotide binding] 264198014981 sequence specific DNA binding site [nucleotide binding]; other site 264198014982 putative cAMP binding site [chemical binding]; other site 264198014983 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 264198014984 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198014985 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198014986 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198014987 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014988 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198014989 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014990 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198014991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198014992 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 264198014993 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198014994 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198014995 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 264198014996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014997 putative substrate translocation pore; other site 264198014998 YabG peptidase U57; Region: Peptidase_U57; cl05250 264198014999 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198015000 BON domain; Region: BON; pfam04972 264198015001 Predicted membrane protein [Function unknown]; Region: COG2323 264198015002 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 264198015003 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 264198015004 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 264198015005 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 264198015006 active site 264198015007 homodimer interface [polypeptide binding]; other site 264198015008 catalytic site [active] 264198015009 acceptor binding site [chemical binding]; other site 264198015010 trehalose synthase; Region: treS_nterm; TIGR02456 264198015011 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 264198015012 active site 264198015013 catalytic site [active] 264198015014 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 264198015015 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 264198015016 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 264198015017 glycogen branching enzyme; Provisional; Region: PRK05402 264198015018 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 264198015019 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 264198015020 active site 264198015021 catalytic site [active] 264198015022 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 264198015023 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 264198015024 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 264198015025 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 264198015026 active site 264198015027 catalytic site [active] 264198015028 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 264198015029 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 264198015030 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 264198015031 homodimer interface [polypeptide binding]; other site 264198015032 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 264198015033 active site pocket [active] 264198015034 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 264198015035 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 264198015036 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 264198015037 catalytic site [active] 264198015038 active site 264198015039 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 264198015040 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 264198015041 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 264198015042 active site 264198015043 catalytic site [active] 264198015044 BON domain; Region: BON; pfam04972 264198015045 BON domain; Region: BON; pfam04972 264198015046 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 264198015047 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264198015048 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198015049 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198015050 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264198015051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198015052 Walker A/P-loop; other site 264198015053 ATP binding site [chemical binding]; other site 264198015054 Q-loop/lid; other site 264198015055 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264198015056 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264198015057 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264198015058 dimerization interface [polypeptide binding]; other site 264198015059 active site 264198015060 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198015061 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 264198015062 AsnC family; Region: AsnC_trans_reg; pfam01037 264198015063 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 264198015064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015065 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 264198015066 putative dimerization interface [polypeptide binding]; other site 264198015067 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 264198015068 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 264198015069 THF binding site; other site 264198015070 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 264198015071 substrate binding site [chemical binding]; other site 264198015072 THF binding site; other site 264198015073 zinc-binding site [ion binding]; other site 264198015074 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264198015075 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198015076 N-terminal plug; other site 264198015077 ligand-binding site [chemical binding]; other site 264198015078 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198015079 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198015080 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 264198015081 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264198015082 nudix motif; other site 264198015083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198015084 Putative zinc-finger; Region: zf-HC2; pfam13490 264198015085 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198015086 RNA polymerase sigma factor; Provisional; Region: PRK12533 264198015087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198015088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198015089 DNA binding residues [nucleotide binding] 264198015090 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198015091 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264198015092 active site 264198015093 metal binding site [ion binding]; metal-binding site 264198015094 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198015095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198015096 S-adenosylmethionine binding site [chemical binding]; other site 264198015097 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198015098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198015099 metal binding site [ion binding]; metal-binding site 264198015100 active site 264198015101 I-site; other site 264198015102 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198015103 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198015104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198015105 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015106 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015107 active site 264198015108 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198015109 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 264198015110 tetrameric interface [polypeptide binding]; other site 264198015111 NAD binding site [chemical binding]; other site 264198015112 catalytic residues [active] 264198015113 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198015114 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 264198015115 enoyl-CoA hydratase; Provisional; Region: PRK09076 264198015116 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015117 substrate binding site [chemical binding]; other site 264198015118 oxyanion hole (OAH) forming residues; other site 264198015119 trimer interface [polypeptide binding]; other site 264198015120 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 264198015121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015122 substrate binding site [chemical binding]; other site 264198015123 oxyanion hole (OAH) forming residues; other site 264198015124 trimer interface [polypeptide binding]; other site 264198015125 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 264198015126 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198015127 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198015128 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 264198015129 putative NAD(P) binding site [chemical binding]; other site 264198015130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015131 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 264198015132 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198015133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 264198015134 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198015135 DNA-binding site [nucleotide binding]; DNA binding site 264198015136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198015137 aminotransferase; Validated; Region: PRK08175 264198015138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198015139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015140 homodimer interface [polypeptide binding]; other site 264198015141 catalytic residue [active] 264198015142 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 264198015143 putative active site [active] 264198015144 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264198015145 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 264198015146 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 264198015147 FAD binding pocket [chemical binding]; other site 264198015148 FAD binding motif [chemical binding]; other site 264198015149 phosphate binding motif [ion binding]; other site 264198015150 NAD binding pocket [chemical binding]; other site 264198015151 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 264198015152 Predicted transcriptional regulators [Transcription]; Region: COG1695 264198015153 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198015154 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198015155 FAD binding domain; Region: FAD_binding_4; pfam01565 264198015156 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 264198015157 succinic semialdehyde dehydrogenase; Region: PLN02278 264198015158 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198015159 tetramerization interface [polypeptide binding]; other site 264198015160 NAD(P) binding site [chemical binding]; other site 264198015161 catalytic residues [active] 264198015162 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198015163 galactarate dehydratase; Region: galactar-dH20; TIGR03248 264198015164 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198015165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015166 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198015167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015169 dimerization interface [polypeptide binding]; other site 264198015170 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 264198015171 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264198015172 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 264198015173 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 264198015174 homodimer interface [polypeptide binding]; other site 264198015175 substrate-cofactor binding pocket; other site 264198015176 catalytic residue [active] 264198015177 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198015178 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 264198015179 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264198015180 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264198015181 Uncharacterized conserved protein [Function unknown]; Region: COG3379 264198015182 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 264198015183 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 264198015184 Phosphoesterase family; Region: Phosphoesterase; pfam04185 264198015185 Domain of unknown function (DUF756); Region: DUF756; pfam05506 264198015186 Domain of unknown function (DUF756); Region: DUF756; pfam05506 264198015187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015188 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198015189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198015190 dimerization interface [polypeptide binding]; other site 264198015191 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 264198015192 putative active site [active] 264198015193 Zn binding site [ion binding]; other site 264198015194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198015195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015199 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198015200 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 264198015201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015204 dimerization interface [polypeptide binding]; other site 264198015205 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198015206 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198015207 metal binding site [ion binding]; metal-binding site 264198015208 putative dimer interface [polypeptide binding]; other site 264198015209 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015210 putative transporter; Provisional; Region: PRK10504 264198015211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015212 putative substrate translocation pore; other site 264198015213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015216 dimerization interface [polypeptide binding]; other site 264198015217 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 264198015218 dimerization interface [polypeptide binding]; other site 264198015219 putative active cleft [active] 264198015220 acyl-CoA synthetase; Validated; Region: PRK08162 264198015221 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 264198015222 acyl-activating enzyme (AAE) consensus motif; other site 264198015223 putative active site [active] 264198015224 AMP binding site [chemical binding]; other site 264198015225 putative CoA binding site [chemical binding]; other site 264198015226 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198015227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198015228 ligand binding site [chemical binding]; other site 264198015229 flexible hinge region; other site 264198015230 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198015231 non-specific DNA interactions [nucleotide binding]; other site 264198015232 DNA binding site [nucleotide binding] 264198015233 sequence specific DNA binding site [nucleotide binding]; other site 264198015234 putative cAMP binding site [chemical binding]; other site 264198015235 Predicted membrane protein [Function unknown]; Region: COG2510 264198015236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015237 putative substrate translocation pore; other site 264198015238 hypothetical protein; Provisional; Region: PRK11667 264198015239 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 264198015240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198015241 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 264198015242 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 264198015243 active site 264198015244 FMN binding site [chemical binding]; other site 264198015245 substrate binding site [chemical binding]; other site 264198015246 homotetramer interface [polypeptide binding]; other site 264198015247 catalytic residue [active] 264198015248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015249 putative substrate translocation pore; other site 264198015250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015253 putative substrate translocation pore; other site 264198015254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015255 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198015256 classical (c) SDRs; Region: SDR_c; cd05233 264198015257 NAD(P) binding site [chemical binding]; other site 264198015258 active site 264198015259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198015263 putative substrate translocation pore; other site 264198015264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015265 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 264198015266 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264198015267 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264198015268 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 264198015269 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 264198015270 generic binding surface I; other site 264198015271 generic binding surface II; other site 264198015272 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 264198015273 putative active site [active] 264198015274 putative catalytic site [active] 264198015275 putative Mg binding site IVb [ion binding]; other site 264198015276 putative phosphate binding site [ion binding]; other site 264198015277 putative DNA binding site [nucleotide binding]; other site 264198015278 putative Mg binding site IVa [ion binding]; other site 264198015279 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198015280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015281 putative substrate translocation pore; other site 264198015282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015283 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 264198015284 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 264198015285 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198015286 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 264198015287 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198015288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198015289 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198015290 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198015291 transcriptional regulator; Provisional; Region: PRK10632 264198015292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015293 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 264198015294 putative effector binding pocket; other site 264198015295 putative dimerization interface [polypeptide binding]; other site 264198015296 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 264198015297 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 264198015298 E-class dimer interface [polypeptide binding]; other site 264198015299 P-class dimer interface [polypeptide binding]; other site 264198015300 active site 264198015301 Cu2+ binding site [ion binding]; other site 264198015302 Zn2+ binding site [ion binding]; other site 264198015303 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198015304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015305 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 264198015306 substrate binding pocket [chemical binding]; other site 264198015307 dimerization interface [polypeptide binding]; other site 264198015308 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198015309 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198015310 iron-sulfur cluster [ion binding]; other site 264198015311 [2Fe-2S] cluster binding site [ion binding]; other site 264198015312 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198015313 alpha subunit interface [polypeptide binding]; other site 264198015314 active site 264198015315 substrate binding site [chemical binding]; other site 264198015316 Fe binding site [ion binding]; other site 264198015317 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198015318 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198015319 FMN-binding pocket [chemical binding]; other site 264198015320 flavin binding motif; other site 264198015321 phosphate binding motif [ion binding]; other site 264198015322 beta-alpha-beta structure motif; other site 264198015323 NAD binding pocket [chemical binding]; other site 264198015324 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198015325 catalytic loop [active] 264198015326 iron binding site [ion binding]; other site 264198015327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198015328 GAF domain; Region: GAF_2; pfam13185 264198015329 GAF domain; Region: GAF; pfam01590 264198015330 PAS domain S-box; Region: sensory_box; TIGR00229 264198015331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198015332 putative active site [active] 264198015333 heme pocket [chemical binding]; other site 264198015334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198015335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198015336 metal binding site [ion binding]; metal-binding site 264198015337 active site 264198015338 I-site; other site 264198015339 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198015340 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264198015341 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198015342 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198015343 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264198015344 HSP70 interaction site [polypeptide binding]; other site 264198015345 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 264198015346 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264198015347 tetramer interface [polypeptide binding]; other site 264198015348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015349 catalytic residue [active] 264198015350 Phasin protein; Region: Phasin_2; pfam09361 264198015351 multidrug resistance protein MdtN; Provisional; Region: PRK10476 264198015352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198015353 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198015354 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198015355 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264198015356 Outer membrane efflux protein; Region: OEP; pfam02321 264198015357 Outer membrane efflux protein; Region: OEP; pfam02321 264198015358 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015359 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 264198015360 Cytochrome c; Region: Cytochrom_C; pfam00034 264198015361 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 264198015362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198015364 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198015365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015367 dimerization interface [polypeptide binding]; other site 264198015368 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198015369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198015370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015371 dimer interface [polypeptide binding]; other site 264198015372 phosphorylation site [posttranslational modification] 264198015373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015374 ATP binding site [chemical binding]; other site 264198015375 Mg2+ binding site [ion binding]; other site 264198015376 G-X-G motif; other site 264198015377 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 264198015378 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 264198015379 metal binding site [ion binding]; metal-binding site 264198015380 dimer interface [polypeptide binding]; other site 264198015381 BON domain; Region: BON; pfam04972 264198015382 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198015383 BON domain; Region: BON; pfam04972 264198015384 BON domain; Region: BON; pfam04972 264198015385 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198015386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198015387 acyl-activating enzyme (AAE) consensus motif; other site 264198015388 AMP binding site [chemical binding]; other site 264198015389 active site 264198015390 CoA binding site [chemical binding]; other site 264198015391 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 264198015392 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 264198015393 active site 264198015394 DNA binding site [nucleotide binding] 264198015395 Int/Topo IB signature motif; other site 264198015396 catalytic residues [active] 264198015397 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 264198015398 BON domain; Region: BON; pfam04972 264198015399 short chain dehydrogenase; Provisional; Region: PRK06701 264198015400 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 264198015401 NAD binding site [chemical binding]; other site 264198015402 metal binding site [ion binding]; metal-binding site 264198015403 active site 264198015404 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 264198015405 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198015406 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264198015407 BON domain; Region: BON; pfam04972 264198015408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198015409 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198015410 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198015411 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198015412 putative active site [active] 264198015413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198015414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264198015415 active site 264198015416 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 264198015417 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 264198015418 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198015419 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198015420 putative active site [active] 264198015421 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 264198015422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198015423 active site 264198015424 motif I; other site 264198015425 motif II; other site 264198015426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198015427 classical (c) SDRs; Region: SDR_c; cd05233 264198015428 NAD(P) binding site [chemical binding]; other site 264198015429 active site 264198015430 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 264198015431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198015432 putative ADP-binding pocket [chemical binding]; other site 264198015433 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 264198015434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198015435 NAD binding site [chemical binding]; other site 264198015436 putative substrate binding site 2 [chemical binding]; other site 264198015437 putative substrate binding site 1 [chemical binding]; other site 264198015438 active site 264198015439 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 264198015440 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198015441 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264198015442 Probable Catalytic site; other site 264198015443 metal-binding site 264198015444 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 264198015445 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264198015446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198015447 Walker A/P-loop; other site 264198015448 ATP binding site [chemical binding]; other site 264198015449 Q-loop/lid; other site 264198015450 ABC transporter signature motif; other site 264198015451 Walker B; other site 264198015452 D-loop; other site 264198015453 H-loop/switch region; other site 264198015454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015455 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015456 active site 264198015457 phosphorylation site [posttranslational modification] 264198015458 intermolecular recognition site; other site 264198015459 dimerization interface [polypeptide binding]; other site 264198015460 FOG: CBS domain [General function prediction only]; Region: COG0517 264198015461 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 264198015462 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 264198015463 Fe-S cluster binding site [ion binding]; other site 264198015464 active site 264198015465 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 264198015466 nudix motif; other site 264198015467 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 264198015468 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198015469 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198015470 octamer interface [polypeptide binding]; other site 264198015471 active site 264198015472 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198015473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015474 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 264198015475 dimerizarion interface [polypeptide binding]; other site 264198015476 CrgA pocket; other site 264198015477 substrate binding pocket [chemical binding]; other site 264198015478 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 264198015479 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 264198015480 dimer interface [polypeptide binding]; other site 264198015481 active site 264198015482 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 264198015483 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 264198015484 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 264198015485 putative alpha subunit interface [polypeptide binding]; other site 264198015486 putative active site [active] 264198015487 putative substrate binding site [chemical binding]; other site 264198015488 Fe binding site [ion binding]; other site 264198015489 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 264198015490 inter-subunit interface; other site 264198015491 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 264198015492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198015493 catalytic loop [active] 264198015494 iron binding site [ion binding]; other site 264198015495 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 264198015496 FAD binding pocket [chemical binding]; other site 264198015497 FAD binding motif [chemical binding]; other site 264198015498 phosphate binding motif [ion binding]; other site 264198015499 beta-alpha-beta structure motif; other site 264198015500 NAD binding pocket [chemical binding]; other site 264198015501 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 264198015502 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 264198015503 putative NAD(P) binding site [chemical binding]; other site 264198015504 active site 264198015505 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 264198015506 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 264198015507 dimanganese center [ion binding]; other site 264198015508 manganese transport protein MntH; Reviewed; Region: PRK00701 264198015509 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264198015510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015512 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198015513 putative dimerization interface [polypeptide binding]; other site 264198015514 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 264198015515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198015516 membrane-bound complex binding site; other site 264198015517 hinge residues; other site 264198015518 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198015519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264198015520 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198015521 FAD binding domain; Region: FAD_binding_4; pfam01565 264198015522 Berberine and berberine like; Region: BBE; pfam08031 264198015523 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 264198015524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015527 dimerization interface [polypeptide binding]; other site 264198015528 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015529 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015530 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015531 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198015532 Beta-lactamase; Region: Beta-lactamase; pfam00144 264198015533 Helix-turn-helix domain; Region: HTH_17; pfam12728 264198015534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198015535 binding surface 264198015536 TPR repeat; Region: TPR_11; pfam13414 264198015537 TPR motif; other site 264198015538 TPR repeat; Region: TPR_11; pfam13414 264198015539 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264198015540 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 264198015541 putative homodimer interface [polypeptide binding]; other site 264198015542 putative DNA binding site [nucleotide binding]; other site 264198015543 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264198015544 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 264198015545 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264198015546 active site 264198015547 DNA binding site [nucleotide binding] 264198015548 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264198015549 DNA binding site [nucleotide binding] 264198015550 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 264198015551 nucleotide binding site [chemical binding]; other site 264198015552 TolA protein; Region: tolA_full; TIGR02794 264198015553 TonB C terminal; Region: TonB_2; pfam13103 264198015554 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 264198015555 heme-binding residues [chemical binding]; other site 264198015556 The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764 264198015557 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 264198015558 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264198015559 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 264198015560 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 264198015561 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 264198015562 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198015563 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264198015564 Cu(I) binding site [ion binding]; other site 264198015565 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 264198015566 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198015567 Cytochrome c; Region: Cytochrom_C; pfam00034 264198015568 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198015569 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 264198015570 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 264198015571 Subunit I/III interface [polypeptide binding]; other site 264198015572 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 264198015573 short chain dehydrogenase; Provisional; Region: PRK07109 264198015574 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 264198015575 putative NAD(P) binding site [chemical binding]; other site 264198015576 active site 264198015577 thiamine pyrophosphate protein; Provisional; Region: PRK08273 264198015578 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 264198015579 PYR/PP interface [polypeptide binding]; other site 264198015580 dimer interface [polypeptide binding]; other site 264198015581 tetramer interface [polypeptide binding]; other site 264198015582 TPP binding site [chemical binding]; other site 264198015583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198015584 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 264198015585 TPP-binding site [chemical binding]; other site 264198015586 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 264198015587 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198015588 metal binding site [ion binding]; metal-binding site 264198015589 substrate binding pocket [chemical binding]; other site 264198015590 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198015591 FAD binding domain; Region: FAD_binding_4; pfam01565 264198015592 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198015593 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198015594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015596 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 264198015597 Thioredoxin; Region: Thioredoxin_4; cl17273 264198015598 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 264198015599 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 264198015600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015601 putative substrate translocation pore; other site 264198015602 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 264198015603 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198015604 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 264198015605 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264198015606 catalytic triad [active] 264198015607 dimer interface [polypeptide binding]; other site 264198015608 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198015609 hypothetical protein; Provisional; Region: PRK06156 264198015610 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 264198015611 active site 264198015612 metal binding site [ion binding]; metal-binding site 264198015613 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198015614 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198015615 ligand binding site [chemical binding]; other site 264198015616 flexible hinge region; other site 264198015617 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198015618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198015619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198015620 hypothetical protein; Provisional; Region: PRK11239 264198015621 Protein of unknown function, DUF480; Region: DUF480; pfam04337 264198015622 flagellar capping protein; Reviewed; Region: fliD; PRK08032 264198015623 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 264198015624 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264198015625 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198015626 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198015627 active site 264198015628 nucleophile elbow; other site 264198015629 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015630 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 264198015631 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264198015632 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198015633 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198015634 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198015635 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198015636 carboxyltransferase (CT) interaction site; other site 264198015637 biotinylation site [posttranslational modification]; other site 264198015638 enoyl-CoA hydratase; Provisional; Region: PRK05995 264198015639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015640 substrate binding site [chemical binding]; other site 264198015641 oxyanion hole (OAH) forming residues; other site 264198015642 trimer interface [polypeptide binding]; other site 264198015643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015645 active site 264198015646 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264198015647 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264198015648 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264198015649 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198015650 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198015651 YtkA-like; Region: YtkA; pfam13115 264198015652 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 264198015653 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198015654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198015655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015656 active site 264198015657 phosphorylation site [posttranslational modification] 264198015658 intermolecular recognition site; other site 264198015659 dimerization interface [polypeptide binding]; other site 264198015660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198015661 DNA binding residues [nucleotide binding] 264198015662 dimerization interface [polypeptide binding]; other site 264198015663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198015664 PAS domain; Region: PAS_9; pfam13426 264198015665 putative active site [active] 264198015666 heme pocket [chemical binding]; other site 264198015667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198015668 PAS fold; Region: PAS_3; pfam08447 264198015669 putative active site [active] 264198015670 heme pocket [chemical binding]; other site 264198015671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198015672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015673 dimer interface [polypeptide binding]; other site 264198015674 phosphorylation site [posttranslational modification] 264198015675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015676 ATP binding site [chemical binding]; other site 264198015677 Mg2+ binding site [ion binding]; other site 264198015678 G-X-G motif; other site 264198015679 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015681 active site 264198015682 phosphorylation site [posttranslational modification] 264198015683 intermolecular recognition site; other site 264198015684 dimerization interface [polypeptide binding]; other site 264198015685 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264198015686 PAS domain; Region: PAS; smart00091 264198015687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015688 dimer interface [polypeptide binding]; other site 264198015689 phosphorylation site [posttranslational modification] 264198015690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015691 ATP binding site [chemical binding]; other site 264198015692 Mg2+ binding site [ion binding]; other site 264198015693 G-X-G motif; other site 264198015694 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015696 active site 264198015697 phosphorylation site [posttranslational modification] 264198015698 intermolecular recognition site; other site 264198015699 dimerization interface [polypeptide binding]; other site 264198015700 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 264198015701 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198015702 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 264198015703 tetramer interface [polypeptide binding]; other site 264198015704 active site 264198015705 Mg2+/Mn2+ binding site [ion binding]; other site 264198015706 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264198015707 metal ion-dependent adhesion site (MIDAS); other site 264198015708 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264198015709 Protein of unknown function DUF58; Region: DUF58; pfam01882 264198015710 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264198015711 metal ion-dependent adhesion site (MIDAS); other site 264198015712 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198015713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198015714 Walker A motif; other site 264198015715 ATP binding site [chemical binding]; other site 264198015716 Walker B motif; other site 264198015717 arginine finger; other site 264198015718 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264198015719 von Willebrand factor type A domain; Region: VWA_2; pfam13519 264198015720 metal ion-dependent adhesion site (MIDAS); other site 264198015721 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264198015722 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264198015723 TPP-binding site [chemical binding]; other site 264198015724 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 264198015725 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 264198015726 active site 264198015727 SUMO-1 interface [polypeptide binding]; other site 264198015728 Coenzyme A transferase; Region: CoA_trans; cl17247 264198015729 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198015730 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198015731 conserved cys residue [active] 264198015732 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 264198015733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198015734 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 264198015735 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 264198015736 gating phenylalanine in ion channel; other site 264198015737 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198015738 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264198015739 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198015740 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198015741 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198015742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015743 putative substrate translocation pore; other site 264198015744 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 264198015745 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 264198015746 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198015747 PYR/PP interface [polypeptide binding]; other site 264198015748 dimer interface [polypeptide binding]; other site 264198015749 TPP binding site [chemical binding]; other site 264198015750 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198015751 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264198015752 TPP-binding site [chemical binding]; other site 264198015753 dimer interface [polypeptide binding]; other site 264198015754 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198015755 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198015756 trimer interface [polypeptide binding]; other site 264198015757 eyelet of channel; other site 264198015758 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 264198015759 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198015760 Na binding site [ion binding]; other site 264198015761 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 264198015762 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198015763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015764 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198015765 putative effector binding pocket; other site 264198015766 dimerization interface [polypeptide binding]; other site 264198015767 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264198015768 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198015769 P-loop; other site 264198015770 Magnesium ion binding site [ion binding]; other site 264198015771 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198015772 Magnesium ion binding site [ion binding]; other site 264198015773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015775 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015776 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264198015777 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264198015778 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 264198015779 active site 264198015780 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 264198015781 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264198015782 conserved cys residue [active] 264198015783 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198015784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198015785 putative DNA binding site [nucleotide binding]; other site 264198015786 putative Zn2+ binding site [ion binding]; other site 264198015787 AsnC family; Region: AsnC_trans_reg; pfam01037 264198015788 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 264198015789 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264198015790 dimer interface [polypeptide binding]; other site 264198015791 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264198015792 active site 264198015793 Fe binding site [ion binding]; other site 264198015794 aromatic amino acid transporter; Provisional; Region: PRK10238 264198015795 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264198015796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198015797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015798 homodimer interface [polypeptide binding]; other site 264198015799 catalytic residue [active] 264198015800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198015801 classical (c) SDRs; Region: SDR_c; cd05233 264198015802 NAD(P) binding site [chemical binding]; other site 264198015803 active site 264198015804 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198015805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198015806 catalytic loop [active] 264198015807 iron binding site [ion binding]; other site 264198015808 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198015809 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198015810 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 264198015811 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198015812 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 264198015813 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198015814 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 264198015815 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 264198015816 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 264198015817 active site 264198015818 intersubunit interface [polypeptide binding]; other site 264198015819 catalytic residue [active] 264198015820 Cytochrome b [Energy production and conversion]; Region: COG3658 264198015821 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 264198015822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 264198015823 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198015824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015826 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198015827 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198015828 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198015829 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015830 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015831 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015832 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198015833 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198015834 active site 264198015835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015836 Cupin domain; Region: Cupin_2; pfam07883 264198015837 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 264198015838 putative uracil binding site [chemical binding]; other site 264198015839 putative active site [active] 264198015840 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 264198015841 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 264198015842 putative active site [active] 264198015843 putative PHP Thumb interface [polypeptide binding]; other site 264198015844 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264198015845 generic binding surface II; other site 264198015846 generic binding surface I; other site 264198015847 DNA Polymerase Y-family; Region: PolY_like; cd03468 264198015848 active site 264198015849 DNA binding site [nucleotide binding] 264198015850 Uncharacterized conserved protein [Function unknown]; Region: COG4544 264198015851 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198015852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015853 substrate binding site [chemical binding]; other site 264198015854 oxyanion hole (OAH) forming residues; other site 264198015855 trimer interface [polypeptide binding]; other site 264198015856 MarR family; Region: MarR_2; pfam12802 264198015857 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198015858 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198015859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198015860 DNA binding site [nucleotide binding] 264198015861 domain linker motif; other site 264198015862 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 264198015863 putative dimerization interface [polypeptide binding]; other site 264198015864 putative ligand binding site [chemical binding]; other site 264198015865 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198015866 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198015867 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 264198015868 active site 264198015869 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 264198015870 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198015871 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198015872 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 264198015873 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 264198015874 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198015875 catalytic residue [active] 264198015876 allantoate amidohydrolase; Reviewed; Region: PRK12893 264198015877 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 264198015878 active site 264198015879 metal binding site [ion binding]; metal-binding site 264198015880 dimer interface [polypeptide binding]; other site 264198015881 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 264198015882 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 264198015883 tetramer interface [polypeptide binding]; other site 264198015884 active site 264198015885 catalytic triad [active] 264198015886 dimer interface [polypeptide binding]; other site 264198015887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015888 D-galactonate transporter; Region: 2A0114; TIGR00893 264198015889 putative substrate translocation pore; other site 264198015890 peptidase; Reviewed; Region: PRK13004 264198015891 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 264198015892 putative metal binding site [ion binding]; other site 264198015893 putative dimer interface [polypeptide binding]; other site 264198015894 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 264198015895 active site 264198015896 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 264198015897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198015898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015899 dimer interface [polypeptide binding]; other site 264198015900 phosphorylation site [posttranslational modification] 264198015901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015902 ATP binding site [chemical binding]; other site 264198015903 Mg2+ binding site [ion binding]; other site 264198015904 G-X-G motif; other site 264198015905 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015907 active site 264198015908 phosphorylation site [posttranslational modification] 264198015909 intermolecular recognition site; other site 264198015910 dimerization interface [polypeptide binding]; other site 264198015911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264198015912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015913 dimer interface [polypeptide binding]; other site 264198015914 phosphorylation site [posttranslational modification] 264198015915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015916 ATP binding site [chemical binding]; other site 264198015917 Mg2+ binding site [ion binding]; other site 264198015918 G-X-G motif; other site 264198015919 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015921 active site 264198015922 phosphorylation site [posttranslational modification] 264198015923 intermolecular recognition site; other site 264198015924 dimerization interface [polypeptide binding]; other site 264198015925 Predicted membrane protein [Function unknown]; Region: COG2855 264198015926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198015928 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198015929 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198015930 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015931 putative amidase; Provisional; Region: PRK06169 264198015932 Amidase; Region: Amidase; pfam01425 264198015933 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198015934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 264198015935 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 264198015936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198015937 ATP binding site [chemical binding]; other site 264198015938 ATP binding site [chemical binding]; other site 264198015939 putative Mg++ binding site [ion binding]; other site 264198015940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198015941 nucleotide binding region [chemical binding]; other site 264198015942 ATP-binding site [chemical binding]; other site 264198015943 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 264198015944 enoyl-CoA hydratase; Provisional; Region: PRK05981 264198015945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015946 substrate binding site [chemical binding]; other site 264198015947 oxyanion hole (OAH) forming residues; other site 264198015948 trimer interface [polypeptide binding]; other site 264198015949 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015950 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198015951 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015952 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015953 enoyl-CoA hydratase; Provisional; Region: PRK09245 264198015954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015955 substrate binding site [chemical binding]; other site 264198015956 oxyanion hole (OAH) forming residues; other site 264198015957 trimer interface [polypeptide binding]; other site 264198015958 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 264198015959 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 264198015960 NAD binding site [chemical binding]; other site 264198015961 homodimer interface [polypeptide binding]; other site 264198015962 homotetramer interface [polypeptide binding]; other site 264198015963 active site 264198015964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198015966 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198015967 dimerization interface [polypeptide binding]; other site 264198015968 substrate binding pocket [chemical binding]; other site 264198015969 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198015970 CoA binding domain; Region: CoA_binding_2; pfam13380 264198015971 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198015972 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198015973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198015974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015975 NAD(P) binding site [chemical binding]; other site 264198015976 active site 264198015977 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198015978 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198015979 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198015980 active site 264198015981 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198015982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015983 active site 264198015984 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198015985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015986 substrate binding site [chemical binding]; other site 264198015987 oxyanion hole (OAH) forming residues; other site 264198015988 trimer interface [polypeptide binding]; other site 264198015989 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 264198015990 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264198015991 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198015992 dimer interface [polypeptide binding]; other site 264198015993 active site 264198015994 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015995 active site 264198015996 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015998 active site 264198015999 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198016000 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198016001 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198016002 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198016003 active site 264198016004 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198016005 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198016006 benzoate transport; Region: 2A0115; TIGR00895 264198016007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016008 putative substrate translocation pore; other site 264198016009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016010 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264198016011 Uncharacterized conserved protein [Function unknown]; Region: COG1262 264198016012 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264198016013 Sulfatase; Region: Sulfatase; pfam00884 264198016014 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 264198016015 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 264198016016 dimer interface [polypeptide binding]; other site 264198016017 active site 264198016018 metal binding site [ion binding]; metal-binding site 264198016019 Cupin domain; Region: Cupin_2; cl17218 264198016020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016021 short chain dehydrogenase; Validated; Region: PRK07069 264198016022 NAD(P) binding site [chemical binding]; other site 264198016023 active site 264198016024 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198016025 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198016026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016027 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198016028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016029 putative substrate translocation pore; other site 264198016030 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 264198016031 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264198016032 Subunit I/III interface [polypeptide binding]; other site 264198016033 Subunit III/IV interface [polypeptide binding]; other site 264198016034 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198016035 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264198016036 D-pathway; other site 264198016037 Putative ubiquinol binding site [chemical binding]; other site 264198016038 Low-spin heme (heme b) binding site [chemical binding]; other site 264198016039 Putative water exit pathway; other site 264198016040 Binuclear center (heme o3/CuB) [ion binding]; other site 264198016041 K-pathway; other site 264198016042 Putative proton exit pathway; other site 264198016043 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 264198016044 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198016045 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264198016046 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198016047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016048 DNA-binding site [nucleotide binding]; DNA binding site 264198016049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198016050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198016051 homodimer interface [polypeptide binding]; other site 264198016052 catalytic residue [active] 264198016053 Protein of unknown function (DUF445); Region: DUF445; pfam04286 264198016054 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 264198016055 DNA polymerase II; Reviewed; Region: PRK05762 264198016056 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 264198016057 active site 264198016058 catalytic site [active] 264198016059 substrate binding site [chemical binding]; other site 264198016060 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 264198016061 active site 264198016062 metal-binding site 264198016063 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 264198016064 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 264198016065 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 264198016066 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198016067 SLBB domain; Region: SLBB; pfam10531 264198016068 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 264198016069 FAD binding domain; Region: FAD_binding_2; pfam00890 264198016070 L-aspartate oxidase; Provisional; Region: PRK06175 264198016071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198016072 catalytic loop [active] 264198016073 iron binding site [ion binding]; other site 264198016074 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198016075 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264198016076 BON domain; Region: BON; pfam04972 264198016077 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198016078 Double zinc ribbon; Region: DZR; pfam12773 264198016079 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198016080 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264198016081 cyclase homology domain; Region: CHD; cd07302 264198016082 nucleotidyl binding site; other site 264198016083 metal binding site [ion binding]; metal-binding site 264198016084 dimer interface [polypeptide binding]; other site 264198016085 Predicted ATPase [General function prediction only]; Region: COG3899 264198016086 AAA ATPase domain; Region: AAA_16; pfam13191 264198016087 Predicted ATPase [General function prediction only]; Region: COG3903 264198016088 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198016089 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198016090 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 264198016091 CoA binding domain; Region: CoA_binding_2; pfam13380 264198016092 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198016093 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198016094 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198016095 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198016096 substrate binding site [chemical binding]; other site 264198016097 oxyanion hole (OAH) forming residues; other site 264198016098 trimer interface [polypeptide binding]; other site 264198016099 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016100 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 264198016101 Predicted permeases [General function prediction only]; Region: COG0701 264198016102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198016103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016104 active site 264198016105 phosphorylation site [posttranslational modification] 264198016106 intermolecular recognition site; other site 264198016107 dimerization interface [polypeptide binding]; other site 264198016108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016109 dimer interface [polypeptide binding]; other site 264198016110 phosphorylation site [posttranslational modification] 264198016111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016112 ATP binding site [chemical binding]; other site 264198016113 Mg2+ binding site [ion binding]; other site 264198016114 G-X-G motif; other site 264198016115 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 264198016116 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264198016117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198016120 dimerization interface [polypeptide binding]; other site 264198016121 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 264198016122 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 264198016123 putative active site [active] 264198016124 Zn binding site [ion binding]; other site 264198016125 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 264198016126 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 264198016127 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264198016128 Predicted integral membrane protein [Function unknown]; Region: COG0392 264198016129 cardiolipin synthase 2; Provisional; Region: PRK11263 264198016130 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264198016131 putative active site [active] 264198016132 catalytic site [active] 264198016133 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198016134 putative active site [active] 264198016135 catalytic site [active] 264198016136 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016137 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016138 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198016139 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 264198016140 active site 264198016141 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 264198016142 Strictosidine synthase; Region: Str_synth; pfam03088 264198016143 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016144 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 264198016145 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198016146 ligand binding site [chemical binding]; other site 264198016147 NAD binding site [chemical binding]; other site 264198016148 dimerization interface [polypeptide binding]; other site 264198016149 catalytic site [active] 264198016150 hypothetical protein; Validated; Region: PRK06201 264198016151 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 264198016152 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198016153 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198016154 Isochorismatase family; Region: Isochorismatase; pfam00857 264198016155 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264198016156 catalytic triad [active] 264198016157 conserved cis-peptide bond; other site 264198016158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198016159 Coenzyme A binding pocket [chemical binding]; other site 264198016160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198016161 D-loop; other site 264198016162 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 264198016163 Walker A/P-loop; other site 264198016164 ATP binding site [chemical binding]; other site 264198016165 Q-loop/lid; other site 264198016166 aromatic amino acid exporter; Provisional; Region: PRK11689 264198016167 Uncharacterized protein family (UPF0254); Region: UPF0254; cl01641 264198016168 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016169 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 264198016170 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198016171 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198016172 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198016173 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198016174 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198016175 active site 264198016176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016177 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198016178 DNA-binding site [nucleotide binding]; DNA binding site 264198016179 FCD domain; Region: FCD; pfam07729 264198016180 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198016181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198016182 putative DNA binding site [nucleotide binding]; other site 264198016183 putative Zn2+ binding site [ion binding]; other site 264198016184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198016185 Coenzyme A binding pocket [chemical binding]; other site 264198016186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198016187 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 264198016188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198016189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198016190 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 264198016191 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 264198016192 NAD(P) binding site [chemical binding]; other site 264198016193 catalytic residues [active] 264198016194 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264198016195 dimer interface [polypeptide binding]; other site 264198016196 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 264198016197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016198 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 264198016199 putative dimerization interface [polypeptide binding]; other site 264198016200 putative substrate binding pocket [chemical binding]; other site 264198016201 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198016202 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 264198016203 putative ligand binding site [chemical binding]; other site 264198016204 NAD binding site [chemical binding]; other site 264198016205 catalytic site [active] 264198016206 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198016208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198016209 DNA binding site [nucleotide binding] 264198016210 domain linker motif; other site 264198016211 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 264198016212 putative dimerization interface [polypeptide binding]; other site 264198016213 putative ligand binding site [chemical binding]; other site 264198016214 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198016215 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 264198016216 active site pocket [active] 264198016217 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016218 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 264198016219 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 264198016220 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198016221 N-terminal plug; other site 264198016222 ligand-binding site [chemical binding]; other site 264198016223 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198016224 Beta-lactamase; Region: Beta-lactamase; pfam00144 264198016225 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 264198016226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198016227 catalytic loop [active] 264198016228 iron binding site [ion binding]; other site 264198016229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198016230 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 264198016231 [4Fe-4S] binding site [ion binding]; other site 264198016232 molybdopterin cofactor binding site; other site 264198016233 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 264198016234 molybdopterin cofactor binding site; other site 264198016235 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 264198016236 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 264198016237 putative dimer interface [polypeptide binding]; other site 264198016238 [2Fe-2S] cluster binding site [ion binding]; other site 264198016239 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198016240 SLBB domain; Region: SLBB; pfam10531 264198016241 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 264198016242 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198016243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016244 putative substrate translocation pore; other site 264198016245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016247 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198016248 putative dimerization interface [polypeptide binding]; other site 264198016249 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198016250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016251 putative substrate translocation pore; other site 264198016252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016254 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 264198016255 putative dimerization interface [polypeptide binding]; other site 264198016256 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 264198016257 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 264198016258 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198016259 N-terminal plug; other site 264198016260 ligand-binding site [chemical binding]; other site 264198016261 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 264198016262 Esterase/lipase [General function prediction only]; Region: COG1647 264198016263 PAS domain S-box; Region: sensory_box; TIGR00229 264198016264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198016265 putative active site [active] 264198016266 heme pocket [chemical binding]; other site 264198016267 formyl-coenzyme A transferase; Provisional; Region: PRK05398 264198016268 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198016269 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 264198016270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198016271 PYR/PP interface [polypeptide binding]; other site 264198016272 dimer interface [polypeptide binding]; other site 264198016273 TPP binding site [chemical binding]; other site 264198016274 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 264198016275 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 264198016276 TPP-binding site; other site 264198016277 dimer interface [polypeptide binding]; other site 264198016278 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198016279 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198016280 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198016281 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 264198016282 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198016283 ligand binding site [chemical binding]; other site 264198016284 homodimer interface [polypeptide binding]; other site 264198016285 NAD(P) binding site [chemical binding]; other site 264198016286 trimer interface B [polypeptide binding]; other site 264198016287 trimer interface A [polypeptide binding]; other site 264198016288 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198016289 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 264198016290 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198016291 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198016292 formyl-coenzyme A transferase; Provisional; Region: PRK05398 264198016293 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198016294 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198016295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016296 DNA-binding site [nucleotide binding]; DNA binding site 264198016297 FCD domain; Region: FCD; pfam07729 264198016298 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264198016299 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264198016300 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264198016301 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 264198016302 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 264198016303 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 264198016304 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198016305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016306 DNA-binding site [nucleotide binding]; DNA binding site 264198016307 FCD domain; Region: FCD; pfam07729 264198016308 EamA-like transporter family; Region: EamA; pfam00892 264198016309 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198016310 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 264198016311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198016312 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 264198016313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198016314 putative active site [active] 264198016315 putative metal binding site [ion binding]; other site 264198016316 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198016317 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198016318 FAD binding domain; Region: FAD_binding_3; pfam01494 264198016319 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198016320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016321 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 264198016322 DNA-binding site [nucleotide binding]; DNA binding site 264198016323 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264198016324 Isochorismatase family; Region: Isochorismatase; pfam00857 264198016325 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198016326 catalytic triad [active] 264198016327 dimer interface [polypeptide binding]; other site 264198016328 conserved cis-peptide bond; other site 264198016329 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 264198016330 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 264198016331 dimer interface [polypeptide binding]; other site 264198016332 TPP-binding site [chemical binding]; other site 264198016333 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264198016334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016336 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198016337 putative effector binding pocket; other site 264198016338 dimerization interface [polypeptide binding]; other site 264198016339 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198016340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016341 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 264198016342 putative effector binding pocket; other site 264198016343 putative dimerization interface [polypeptide binding]; other site 264198016344 Pirin-related protein [General function prediction only]; Region: COG1741 264198016345 Pirin; Region: Pirin; pfam02678 264198016346 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264198016347 Isochorismatase family; Region: Isochorismatase; pfam00857 264198016348 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198016349 catalytic triad [active] 264198016350 dimer interface [polypeptide binding]; other site 264198016351 conserved cis-peptide bond; other site 264198016352 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 264198016353 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198016354 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198016355 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198016356 YCII-related domain; Region: YCII; cl00999 264198016357 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198016358 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198016359 active site 264198016360 dimer interface [polypeptide binding]; other site 264198016361 metal binding site [ion binding]; metal-binding site 264198016362 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 264198016363 putative hydrolase; Provisional; Region: PRK11460 264198016364 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 264198016365 Zn binding site [ion binding]; other site 264198016366 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 264198016367 Zn binding site [ion binding]; other site 264198016368 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198016369 active site 264198016370 oxalacetate binding site [chemical binding]; other site 264198016371 citrylCoA binding site [chemical binding]; other site 264198016372 coenzyme A binding site [chemical binding]; other site 264198016373 catalytic triad [active] 264198016374 acyl-CoA synthetase; Validated; Region: PRK06188 264198016375 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198016376 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198016377 acyl-activating enzyme (AAE) consensus motif; other site 264198016378 acyl-activating enzyme (AAE) consensus motif; other site 264198016379 putative AMP binding site [chemical binding]; other site 264198016380 putative active site [active] 264198016381 putative CoA binding site [chemical binding]; other site 264198016382 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198016383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016384 DNA-binding site [nucleotide binding]; DNA binding site 264198016385 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198016386 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 264198016387 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 264198016388 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 264198016389 thymidine phosphorylase; Provisional; Region: PRK04350 264198016390 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264198016391 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264198016392 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 264198016393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198016394 Ligand Binding Site [chemical binding]; other site 264198016395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198016396 Ligand Binding Site [chemical binding]; other site 264198016397 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198016398 Ligand Binding Site [chemical binding]; other site 264198016399 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 264198016400 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198016401 putative NAD(P) binding site [chemical binding]; other site 264198016402 putative substrate binding site [chemical binding]; other site 264198016403 catalytic Zn binding site [ion binding]; other site 264198016404 structural Zn binding site [ion binding]; other site 264198016405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198016406 active site 264198016407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198016408 I-site; other site 264198016409 metal binding site [ion binding]; metal-binding site 264198016410 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264198016411 Sulfatase; Region: Sulfatase; cl17466 264198016412 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198016413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198016414 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 264198016415 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198016416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198016418 putative substrate translocation pore; other site 264198016419 pyruvate carboxylase; Reviewed; Region: PRK12999 264198016420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198016421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198016422 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198016423 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 264198016424 active site 264198016425 catalytic residues [active] 264198016426 metal binding site [ion binding]; metal-binding site 264198016427 homodimer binding site [polypeptide binding]; other site 264198016428 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198016429 carboxyltransferase (CT) interaction site; other site 264198016430 biotinylation site [posttranslational modification]; other site 264198016431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016433 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 264198016434 substrate binding pocket [chemical binding]; other site 264198016435 dimerization interface [polypeptide binding]; other site 264198016436 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198016437 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198016438 iron-sulfur cluster [ion binding]; other site 264198016439 [2Fe-2S] cluster binding site [ion binding]; other site 264198016440 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 264198016441 putative alpha subunit interface [polypeptide binding]; other site 264198016442 putative active site [active] 264198016443 putative substrate binding site [chemical binding]; other site 264198016444 Fe binding site [ion binding]; other site 264198016445 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 264198016446 inter-subunit interface; other site 264198016447 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198016448 [2Fe-2S] cluster binding site [ion binding]; other site 264198016449 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198016450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198016451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016452 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198016453 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198016454 putative catalytic residue [active] 264198016455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198016456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198016457 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 264198016458 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 264198016459 putative NAD(P) binding site [chemical binding]; other site 264198016460 active site 264198016461 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264198016462 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198016463 HSP70 interaction site [polypeptide binding]; other site 264198016464 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264198016465 Zn binding sites [ion binding]; other site 264198016466 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264198016467 dimer interface [polypeptide binding]; other site 264198016468 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198016469 Isochorismatase family; Region: Isochorismatase; pfam00857 264198016470 catalytic triad [active] 264198016471 dimer interface [polypeptide binding]; other site 264198016472 conserved cis-peptide bond; other site 264198016473 transcriptional regulator; Provisional; Region: PRK10632 264198016474 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 264198016475 putative effector binding pocket; other site 264198016476 putative dimerization interface [polypeptide binding]; other site 264198016477 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198016478 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 264198016479 putative C-terminal domain interface [polypeptide binding]; other site 264198016480 putative GSH binding site (G-site) [chemical binding]; other site 264198016481 putative dimer interface [polypeptide binding]; other site 264198016482 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 264198016483 putative N-terminal domain interface [polypeptide binding]; other site 264198016484 putative dimer interface [polypeptide binding]; other site 264198016485 putative substrate binding pocket (H-site) [chemical binding]; other site 264198016486 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198016487 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264198016488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016490 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198016491 dimerization interface [polypeptide binding]; other site 264198016492 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 264198016493 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198016494 putative NAD(P) binding site [chemical binding]; other site 264198016495 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 264198016496 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264198016497 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 264198016498 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264198016499 DNA binding site [nucleotide binding] 264198016500 active site 264198016501 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 264198016502 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198016503 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 264198016504 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264198016505 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264198016506 putative acyltransferase; Provisional; Region: PRK05790 264198016507 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198016508 dimer interface [polypeptide binding]; other site 264198016509 active site 264198016510 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 264198016511 putative cation:proton antiport protein; Provisional; Region: PRK10669 264198016512 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 264198016513 TrkA-N domain; Region: TrkA_N; pfam02254 264198016514 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198016515 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198016516 dimer interface [polypeptide binding]; other site 264198016517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198016518 catalytic residue [active] 264198016519 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198016520 Ligand Binding Site [chemical binding]; other site 264198016521 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198016522 Ligand Binding Site [chemical binding]; other site 264198016523 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 264198016524 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 264198016525 ligand binding site [chemical binding]; other site 264198016526 NAD binding site [chemical binding]; other site 264198016527 tetramer interface [polypeptide binding]; other site 264198016528 catalytic site [active] 264198016529 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 264198016530 L-serine binding site [chemical binding]; other site 264198016531 ACT domain interface; other site 264198016532 choline dehydrogenase; Validated; Region: PRK02106 264198016533 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198016534 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198016535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198016536 NAD binding site [chemical binding]; other site 264198016537 catalytic residues [active] 264198016538 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198016539 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198016540 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198016542 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198016543 active site 264198016544 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198016545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016546 NAD(P) binding site [chemical binding]; other site 264198016547 active site 264198016548 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 264198016549 active site 264198016550 catalytic site [active] 264198016551 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 264198016552 active site 264198016553 catalytic site [active] 264198016554 lipid-transfer protein; Provisional; Region: PRK08256 264198016555 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198016556 active site 264198016557 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198016558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198016559 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198016560 acyl-activating enzyme (AAE) consensus motif; other site 264198016561 acyl-activating enzyme (AAE) consensus motif; other site 264198016562 putative AMP binding site [chemical binding]; other site 264198016563 putative active site [active] 264198016564 putative CoA binding site [chemical binding]; other site 264198016565 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198016566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198016567 DNA binding residues [nucleotide binding] 264198016568 dimerization interface [polypeptide binding]; other site 264198016569 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 264198016570 NapD protein; Region: NapD; pfam03927 264198016571 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 264198016572 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 264198016573 [4Fe-4S] binding site [ion binding]; other site 264198016574 molybdopterin cofactor binding site; other site 264198016575 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 264198016576 molybdopterin cofactor binding site; other site 264198016577 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 264198016578 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 264198016579 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 264198016580 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 264198016581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198016582 Walker A/P-loop; other site 264198016583 ATP binding site [chemical binding]; other site 264198016584 Q-loop/lid; other site 264198016585 ABC transporter signature motif; other site 264198016586 Walker B; other site 264198016587 D-loop; other site 264198016588 H-loop/switch region; other site 264198016589 CcmB protein; Region: CcmB; cl17444 264198016590 heme exporter protein CcmC; Region: ccmC; TIGR01191 264198016591 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 264198016592 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 264198016593 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 264198016594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264198016595 catalytic residues [active] 264198016596 central insert; other site 264198016597 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 264198016598 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 264198016599 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 264198016600 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198016601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016602 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198016603 dimerization interface [polypeptide binding]; other site 264198016604 substrate binding pocket [chemical binding]; other site 264198016605 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198016606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016607 NAD(P) binding site [chemical binding]; other site 264198016608 active site 264198016609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016610 D-galactonate transporter; Region: 2A0114; TIGR00893 264198016611 putative substrate translocation pore; other site 264198016612 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264198016613 TPP-binding site [chemical binding]; other site 264198016614 dimer interface [polypeptide binding]; other site 264198016615 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 264198016616 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264198016617 PYR/PP interface [polypeptide binding]; other site 264198016618 dimer interface [polypeptide binding]; other site 264198016619 TPP binding site [chemical binding]; other site 264198016620 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198016621 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198016622 CoenzymeA binding site [chemical binding]; other site 264198016623 subunit interaction site [polypeptide binding]; other site 264198016624 PHB binding site; other site 264198016625 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198016626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198016627 substrate binding site [chemical binding]; other site 264198016628 oxyanion hole (OAH) forming residues; other site 264198016629 trimer interface [polypeptide binding]; other site 264198016630 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198016631 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 264198016632 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198016633 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate; Region: 3MGA_Dioxygenase; cd07366 264198016634 putative active site [active] 264198016635 putative Fe(II) binding site [ion binding]; other site 264198016636 putative dimer interface [polypeptide binding]; other site 264198016637 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264198016638 putative tetramer interface [polypeptide binding]; other site 264198016639 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198016640 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198016641 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 264198016642 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198016643 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198016644 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198016645 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198016646 active site 264198016647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016648 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198016649 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198016650 active site 264198016651 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198016652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198016653 active site 264198016654 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198016655 CoA binding domain; Region: CoA_binding_2; pfam13380 264198016656 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198016657 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198016658 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264198016659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016660 DNA-binding site [nucleotide binding]; DNA binding site 264198016661 FCD domain; Region: FCD; pfam07729 264198016662 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198016663 homotrimer interaction site [polypeptide binding]; other site 264198016664 putative active site [active] 264198016665 Amidohydrolase; Region: Amidohydro_2; pfam04909 264198016666 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198016667 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198016668 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198016669 alpha subunit interface [polypeptide binding]; other site 264198016670 active site 264198016671 substrate binding site [chemical binding]; other site 264198016672 Fe binding site [ion binding]; other site 264198016673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016674 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198016675 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198016676 FMN-binding pocket [chemical binding]; other site 264198016677 flavin binding motif; other site 264198016678 phosphate binding motif [ion binding]; other site 264198016679 beta-alpha-beta structure motif; other site 264198016680 NAD binding pocket [chemical binding]; other site 264198016681 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198016682 catalytic loop [active] 264198016683 iron binding site [ion binding]; other site 264198016684 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198016685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198016686 substrate binding site [chemical binding]; other site 264198016687 oxyanion hole (OAH) forming residues; other site 264198016688 trimer interface [polypeptide binding]; other site 264198016689 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264198016690 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 264198016691 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198016692 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198016693 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198016694 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016695 trimer interface [polypeptide binding]; other site 264198016696 eyelet of channel; other site 264198016697 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198016698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016699 DNA-binding site [nucleotide binding]; DNA binding site 264198016700 FCD domain; Region: FCD; pfam07729 264198016701 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198016702 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 264198016703 NAD binding site [chemical binding]; other site 264198016704 homodimer interface [polypeptide binding]; other site 264198016705 active site 264198016706 putative substrate binding site [chemical binding]; other site 264198016707 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 264198016708 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 264198016709 substrate-cofactor binding pocket; other site 264198016710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198016711 catalytic residue [active] 264198016712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198016713 sequence-specific DNA binding site [nucleotide binding]; other site 264198016714 salt bridge; other site 264198016715 Cupin domain; Region: Cupin_2; pfam07883 264198016716 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264198016717 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198016718 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264198016719 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 264198016720 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198016721 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198016722 dimerization interface [polypeptide binding]; other site 264198016723 ligand binding site [chemical binding]; other site 264198016724 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198016725 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264198016726 conserved cys residue [active] 264198016727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198016730 dimer interface [polypeptide binding]; other site 264198016731 conserved gate region; other site 264198016732 putative PBP binding loops; other site 264198016733 ABC-ATPase subunit interface; other site 264198016734 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 264198016735 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 264198016736 Walker A/P-loop; other site 264198016737 ATP binding site [chemical binding]; other site 264198016738 Q-loop/lid; other site 264198016739 ABC transporter signature motif; other site 264198016740 Walker B; other site 264198016741 D-loop; other site 264198016742 H-loop/switch region; other site 264198016743 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264198016744 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 264198016745 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264198016746 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264198016747 putative active site [active] 264198016748 putative substrate binding site [chemical binding]; other site 264198016749 putative cosubstrate binding site; other site 264198016750 catalytic site [active] 264198016751 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 264198016752 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264198016753 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198016754 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 264198016755 FAD binding pocket [chemical binding]; other site 264198016756 FAD binding motif [chemical binding]; other site 264198016757 phosphate binding motif [ion binding]; other site 264198016758 beta-alpha-beta structure motif; other site 264198016759 NAD binding pocket [chemical binding]; other site 264198016760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198016761 catalytic loop [active] 264198016762 iron binding site [ion binding]; other site 264198016763 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198016764 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198016765 [2Fe-2S] cluster binding site [ion binding]; other site 264198016766 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 264198016767 putative alpha subunit interface [polypeptide binding]; other site 264198016768 putative active site [active] 264198016769 putative substrate binding site [chemical binding]; other site 264198016770 Fe binding site [ion binding]; other site 264198016771 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264198016772 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264198016773 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264198016774 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 264198016775 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264198016776 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 264198016777 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198016778 Cysteine-rich domain; Region: CCG; pfam02754 264198016779 Cysteine-rich domain; Region: CCG; pfam02754 264198016780 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 264198016781 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 264198016782 putative active site [active] 264198016783 putative FMN binding site [chemical binding]; other site 264198016784 putative substrate binding site [chemical binding]; other site 264198016785 putative catalytic residue [active] 264198016786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264198016787 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 264198016788 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 264198016789 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 264198016790 active site 264198016791 dimer interface [polypeptide binding]; other site 264198016792 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 264198016793 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264198016794 dimer interface [polypeptide binding]; other site 264198016795 active site 264198016796 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264198016797 folate binding site [chemical binding]; other site 264198016798 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198016799 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264198016800 conserved cys residue [active] 264198016801 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 264198016802 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 264198016803 NAD binding site [chemical binding]; other site 264198016804 catalytic Zn binding site [ion binding]; other site 264198016805 structural Zn binding site [ion binding]; other site 264198016806 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198016807 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016808 trimer interface [polypeptide binding]; other site 264198016809 eyelet of channel; other site 264198016810 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 264198016811 active site 264198016812 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 264198016813 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 264198016814 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 264198016815 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198016816 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 264198016817 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 264198016818 hydroxyglutarate oxidase; Provisional; Region: PRK11728 264198016819 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264198016820 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264198016821 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 264198016822 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198016823 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264198016824 conserved cys residue [active] 264198016825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016826 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 264198016827 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 264198016828 substrate binding site [chemical binding]; other site 264198016829 catalytic Zn binding site [ion binding]; other site 264198016830 NAD binding site [chemical binding]; other site 264198016831 structural Zn binding site [ion binding]; other site 264198016832 dimer interface [polypeptide binding]; other site 264198016833 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198016834 Double zinc ribbon; Region: DZR; pfam12773 264198016835 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 264198016836 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264198016837 cyclase homology domain; Region: CHD; cd07302 264198016838 nucleotidyl binding site; other site 264198016839 metal binding site [ion binding]; metal-binding site 264198016840 dimer interface [polypeptide binding]; other site 264198016841 Predicted ATPase [General function prediction only]; Region: COG3899 264198016842 AAA ATPase domain; Region: AAA_16; pfam13191 264198016843 Predicted ATPase [General function prediction only]; Region: COG3903 264198016844 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264198016845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016847 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 264198016848 putative dimerization interface [polypeptide binding]; other site 264198016849 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264198016850 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264198016851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016852 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198016853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016854 DNA-binding site [nucleotide binding]; DNA binding site 264198016855 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198016856 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 264198016857 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198016858 tetramer interface [polypeptide binding]; other site 264198016859 active site 264198016860 Mg2+/Mn2+ binding site [ion binding]; other site 264198016861 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 264198016862 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264198016863 substrate binding site [chemical binding]; other site 264198016864 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264198016865 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 264198016866 substrate binding site [chemical binding]; other site 264198016867 ligand binding site [chemical binding]; other site 264198016868 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198016869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016870 putative substrate translocation pore; other site 264198016871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198016872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016873 putative substrate translocation pore; other site 264198016874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198016875 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 264198016876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198016877 dimerization interface [polypeptide binding]; other site 264198016878 Predicted membrane protein [Function unknown]; Region: COG2259 264198016879 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198016880 Isochorismatase family; Region: Isochorismatase; pfam00857 264198016881 catalytic triad [active] 264198016882 dimer interface [polypeptide binding]; other site 264198016883 conserved cis-peptide bond; other site 264198016884 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 264198016885 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 264198016886 active site 264198016887 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 264198016888 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 264198016889 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 264198016890 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 264198016891 cyclase homology domain; Region: CHD; cd07302 264198016892 nucleotidyl binding site; other site 264198016893 metal binding site [ion binding]; metal-binding site 264198016894 dimer interface [polypeptide binding]; other site 264198016895 FHA domain; Region: FHA; pfam00498 264198016896 phosphopeptide binding site; other site 264198016897 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198016898 classical (c) SDRs; Region: SDR_c; cd05233 264198016899 NAD(P) binding site [chemical binding]; other site 264198016900 active site 264198016901 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 264198016902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198016904 Coenzyme A binding pocket [chemical binding]; other site 264198016905 Predicted transcriptional regulators [Transcription]; Region: COG1733 264198016906 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 264198016907 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 264198016908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016909 nitrite reductase subunit NirD; Provisional; Region: PRK14989 264198016910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016911 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264198016912 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198016913 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 264198016914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 264198016915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016916 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198016917 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 264198016918 [4Fe-4S] binding site [ion binding]; other site 264198016919 molybdopterin cofactor binding site; other site 264198016920 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 264198016921 molybdopterin cofactor binding site; other site 264198016922 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 264198016923 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198016924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198016925 metal binding site [ion binding]; metal-binding site 264198016926 active site 264198016927 I-site; other site 264198016928 putative transporter; Provisional; Region: PRK10504 264198016929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016930 putative substrate translocation pore; other site 264198016931 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264198016932 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198016933 N-terminal plug; other site 264198016934 ligand-binding site [chemical binding]; other site 264198016935 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 264198016936 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264198016937 feruloyl-CoA synthase; Reviewed; Region: PRK08180 264198016938 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 264198016939 acyl-activating enzyme (AAE) consensus motif; other site 264198016940 putative AMP binding site [chemical binding]; other site 264198016941 putative active site [active] 264198016942 putative CoA binding site [chemical binding]; other site 264198016943 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198016944 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 264198016945 NAD(P) binding site [chemical binding]; other site 264198016946 catalytic residues [active] 264198016947 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 264198016948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198016949 substrate binding site [chemical binding]; other site 264198016950 oxyanion hole (OAH) forming residues; other site 264198016951 trimer interface [polypeptide binding]; other site 264198016952 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198016953 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016954 trimer interface [polypeptide binding]; other site 264198016955 eyelet of channel; other site 264198016956 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 264198016957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016958 putative substrate translocation pore; other site 264198016959 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264198016960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198016961 MarR family; Region: MarR_2; pfam12802 264198016962 Transglycosylase; Region: Transgly; pfam00912 264198016963 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264198016964 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264198016965 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198016966 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 264198016968 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 264198016969 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198016970 EamA-like transporter family; Region: EamA; pfam00892 264198016971 Cupin domain; Region: Cupin_2; cl17218 264198016972 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198016973 allophanate hydrolase; Provisional; Region: PRK08186 264198016974 Amidase; Region: Amidase; cl11426 264198016975 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 264198016976 urea carboxylase; Region: urea_carbox; TIGR02712 264198016977 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198016978 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264198016979 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264198016980 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 264198016981 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 264198016982 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198016983 carboxyltransferase (CT) interaction site; other site 264198016984 biotinylation site [posttranslational modification]; other site 264198016985 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 264198016986 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 264198016987 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 264198016988 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 264198016989 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198016990 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198016991 Walker A/P-loop; other site 264198016992 ATP binding site [chemical binding]; other site 264198016993 Q-loop/lid; other site 264198016994 ABC transporter signature motif; other site 264198016995 Walker B; other site 264198016996 D-loop; other site 264198016997 H-loop/switch region; other site 264198016998 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198016999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198017000 dimer interface [polypeptide binding]; other site 264198017001 conserved gate region; other site 264198017002 putative PBP binding loops; other site 264198017003 ABC-ATPase subunit interface; other site 264198017004 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 264198017005 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198017006 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198017007 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 264198017008 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264198017009 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264198017010 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198017011 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264198017012 D-pathway; other site 264198017013 Putative ubiquinol binding site [chemical binding]; other site 264198017014 Low-spin heme (heme b) binding site [chemical binding]; other site 264198017015 Putative water exit pathway; other site 264198017016 Binuclear center (heme o3/CuB) [ion binding]; other site 264198017017 K-pathway; other site 264198017018 Putative proton exit pathway; other site 264198017019 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264198017020 Subunit I/III interface [polypeptide binding]; other site 264198017021 Subunit III/IV interface [polypeptide binding]; other site 264198017022 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 264198017023 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264198017024 Spore germination protein; Region: Spore_permease; cl17796 264198017025 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 264198017026 active site 264198017027 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 264198017028 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 264198017029 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 264198017030 putative NADP binding site [chemical binding]; other site 264198017031 putative substrate binding site [chemical binding]; other site 264198017032 active site 264198017033 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 264198017034 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 264198017035 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 264198017036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198017037 FeS/SAM binding site; other site 264198017038 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 264198017039 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 264198017040 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 264198017041 ligand binding site; other site 264198017042 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 264198017043 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 264198017044 B12 binding site [chemical binding]; other site 264198017045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198017046 FeS/SAM binding site; other site 264198017047 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 264198017048 putative membrane protein; Region: HpnL; TIGR03476 264198017049 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 264198017050 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 264198017051 VacJ like lipoprotein; Region: VacJ; cl01073 264198017052 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264198017053 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264198017054 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 264198017055 threonine dehydratase; Reviewed; Region: PRK09224 264198017056 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264198017057 tetramer interface [polypeptide binding]; other site 264198017058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198017059 catalytic residue [active] 264198017060 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264198017061 putative Ile/Val binding site [chemical binding]; other site 264198017062 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264198017063 putative Ile/Val binding site [chemical binding]; other site 264198017064 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 264198017065 Resolvase, N terminal domain; Region: Resolvase; pfam00239 264198017066 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 264198017067 catalytic residues [active] 264198017068 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264198017069 DNA-binding interface [nucleotide binding]; DNA binding site 264198017070 CheB methylesterase; Region: CheB_methylest; pfam01339 264198017071 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264198017072 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264198017073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198017074 S-adenosylmethionine binding site [chemical binding]; other site 264198017075 PAS fold; Region: PAS; pfam00989 264198017076 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 264198017077 PAS domain; Region: PAS_10; pfam13596 264198017078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017079 putative active site [active] 264198017080 heme pocket [chemical binding]; other site 264198017081 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198017082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017083 putative active site [active] 264198017084 heme pocket [chemical binding]; other site 264198017085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017086 dimer interface [polypeptide binding]; other site 264198017087 phosphorylation site [posttranslational modification] 264198017088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017089 ATP binding site [chemical binding]; other site 264198017090 Mg2+ binding site [ion binding]; other site 264198017091 G-X-G motif; other site 264198017092 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264198017093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017094 active site 264198017095 phosphorylation site [posttranslational modification] 264198017096 intermolecular recognition site; other site 264198017097 dimerization interface [polypeptide binding]; other site 264198017098 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264198017099 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264198017100 PRC-barrel domain; Region: PRC; pfam05239 264198017101 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 264198017102 Phasin protein; Region: Phasin_2; pfam09361 264198017103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017105 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 264198017106 putative dimerization interface [polypeptide binding]; other site 264198017107 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 264198017108 Coenzyme A transferase; Region: CoA_trans; cl17247 264198017109 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 264198017110 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 264198017111 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 264198017112 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 264198017113 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 264198017114 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 264198017115 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264198017116 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 264198017117 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 264198017118 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198017119 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198017120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 264198017121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198017122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198017123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198017124 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198017125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198017126 S-adenosylmethionine binding site [chemical binding]; other site 264198017127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198017128 active site 264198017129 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198017130 CoenzymeA binding site [chemical binding]; other site 264198017131 subunit interaction site [polypeptide binding]; other site 264198017132 PHB binding site; other site 264198017133 CHASE2 domain; Region: CHASE2; pfam05226 264198017134 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198017135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017136 dimer interface [polypeptide binding]; other site 264198017137 phosphorylation site [posttranslational modification] 264198017138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017139 ATP binding site [chemical binding]; other site 264198017140 Mg2+ binding site [ion binding]; other site 264198017141 G-X-G motif; other site 264198017142 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198017143 FecR protein; Region: FecR; pfam04773 264198017144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198017145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017146 active site 264198017147 phosphorylation site [posttranslational modification] 264198017148 intermolecular recognition site; other site 264198017149 dimerization interface [polypeptide binding]; other site 264198017150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198017151 DNA binding site [nucleotide binding] 264198017152 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264198017153 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926 264198017154 putative active site [active] 264198017155 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 264198017156 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198017157 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 264198017158 DXD motif; other site 264198017159 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 264198017160 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264198017161 active site 264198017162 homodimer interface [polypeptide binding]; other site 264198017163 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198017164 DNA-binding site [nucleotide binding]; DNA binding site 264198017165 RNA-binding motif; other site 264198017166 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264198017167 active site lid residues [active] 264198017168 substrate binding pocket [chemical binding]; other site 264198017169 catalytic residues [active] 264198017170 substrate-Mg2+ binding site; other site 264198017171 aspartate-rich region 1; other site 264198017172 aspartate-rich region 2; other site 264198017173 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 264198017174 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 264198017175 Active site cavity [active] 264198017176 catalytic acid [active] 264198017177 hypothetical protein; Provisional; Region: PRK07077 264198017178 putative chaperone; Provisional; Region: PRK11678 264198017179 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 264198017180 nucleotide binding site [chemical binding]; other site 264198017181 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264198017182 SBD interface [polypeptide binding]; other site 264198017183 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198017184 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198017185 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198017186 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198017187 active site 264198017188 citrylCoA binding site [chemical binding]; other site 264198017189 oxalacetate binding site [chemical binding]; other site 264198017190 coenzyme A binding site [chemical binding]; other site 264198017191 catalytic triad [active] 264198017192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198017193 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198017194 metal binding site [ion binding]; metal-binding site 264198017195 active site 264198017196 I-site; other site 264198017197 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198017198 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198017199 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198017200 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 264198017201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017203 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198017204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198017205 S-adenosylmethionine binding site [chemical binding]; other site 264198017206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198017207 putative PBP binding loops; other site 264198017208 dimer interface [polypeptide binding]; other site 264198017209 ABC-ATPase subunit interface; other site 264198017210 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264198017211 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 264198017212 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264198017213 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 264198017214 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198017215 homodimer interface [polypeptide binding]; other site 264198017216 substrate-cofactor binding pocket; other site 264198017217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198017218 catalytic residue [active] 264198017219 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 264198017220 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 264198017221 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 264198017222 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 264198017223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198017224 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 264198017225 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 264198017226 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264198017227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264198017228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017229 dimer interface [polypeptide binding]; other site 264198017230 phosphorylation site [posttranslational modification] 264198017231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017232 ATP binding site [chemical binding]; other site 264198017233 Mg2+ binding site [ion binding]; other site 264198017234 G-X-G motif; other site 264198017235 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017237 active site 264198017238 phosphorylation site [posttranslational modification] 264198017239 intermolecular recognition site; other site 264198017240 dimerization interface [polypeptide binding]; other site 264198017241 PAS domain S-box; Region: sensory_box; TIGR00229 264198017242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017243 putative active site [active] 264198017244 heme pocket [chemical binding]; other site 264198017245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198017246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017247 dimer interface [polypeptide binding]; other site 264198017248 phosphorylation site [posttranslational modification] 264198017249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017250 ATP binding site [chemical binding]; other site 264198017251 Mg2+ binding site [ion binding]; other site 264198017252 G-X-G motif; other site 264198017253 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264198017254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017255 active site 264198017256 phosphorylation site [posttranslational modification] 264198017257 intermolecular recognition site; other site 264198017258 dimerization interface [polypeptide binding]; other site 264198017259 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 264198017260 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264198017261 tetramer interface [polypeptide binding]; other site 264198017262 TPP-binding site [chemical binding]; other site 264198017263 heterodimer interface [polypeptide binding]; other site 264198017264 phosphorylation loop region [posttranslational modification] 264198017265 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264198017266 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 264198017267 alpha subunit interface [polypeptide binding]; other site 264198017268 TPP binding site [chemical binding]; other site 264198017269 heterodimer interface [polypeptide binding]; other site 264198017270 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198017271 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 264198017272 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198017273 E3 interaction surface; other site 264198017274 lipoyl attachment site [posttranslational modification]; other site 264198017275 e3 binding domain; Region: E3_binding; pfam02817 264198017276 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264198017277 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 264198017278 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 264198017279 putative active site [active] 264198017280 catalytic site [active] 264198017281 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264198017282 putative active site [active] 264198017283 catalytic site [active] 264198017284 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198017285 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264198017286 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264198017287 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198017288 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198017289 Ligand Binding Site [chemical binding]; other site 264198017290 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264198017291 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 264198017292 dimer interface [polypeptide binding]; other site 264198017293 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264198017294 catalytic triad [active] 264198017295 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 264198017296 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264198017297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017298 active site 264198017299 phosphorylation site [posttranslational modification] 264198017300 intermolecular recognition site; other site 264198017301 dimerization interface [polypeptide binding]; other site 264198017302 Ubiquitin-like proteins; Region: UBQ; cl00155 264198017303 charged pocket; other site 264198017304 hydrophobic patch; other site 264198017305 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198017306 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264198017307 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264198017308 H-NS histone family; Region: Histone_HNS; pfam00816 264198017309 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198017310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017311 transcriptional activator TtdR; Provisional; Region: PRK09801 264198017312 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198017313 putative effector binding pocket; other site 264198017314 dimerization interface [polypeptide binding]; other site 264198017315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017316 MFS transport protein AraJ; Provisional; Region: PRK10091 264198017317 putative substrate translocation pore; other site 264198017318 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198017319 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 264198017320 active site 264198017321 nucleotide binding site [chemical binding]; other site 264198017322 HIGH motif; other site 264198017323 KMSKS motif; other site 264198017324 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 264198017325 LicD family; Region: LicD; pfam04991 264198017326 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 264198017327 Autotransporter beta-domain; Region: Autotransporter; smart00869 264198017328 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198017329 NnrS protein; Region: NnrS; pfam05940 264198017330 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 264198017331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017332 putative substrate translocation pore; other site 264198017333 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 264198017334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017335 putative substrate translocation pore; other site 264198017336 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 264198017337 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 264198017338 [4Fe-4S] binding site [ion binding]; other site 264198017339 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198017340 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198017341 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198017342 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 264198017343 molybdopterin cofactor binding site; other site 264198017344 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 264198017345 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 264198017346 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 264198017347 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 264198017348 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 264198017349 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 264198017350 active site clefts [active] 264198017351 zinc binding site [ion binding]; other site 264198017352 dimer interface [polypeptide binding]; other site 264198017353 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 264198017354 Walker A motif; other site 264198017355 DGC domain; Region: DGC; pfam08859 264198017356 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198017357 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198017358 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 264198017359 Cytochrome c; Region: Cytochrom_C; cl11414 264198017360 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198017361 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 264198017362 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198017363 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198017364 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198017365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264198017366 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198017367 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 264198017368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198017369 FeS/SAM binding site; other site 264198017370 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 264198017371 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198017372 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 264198017373 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 264198017374 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 264198017375 active site 264198017376 SAM binding site [chemical binding]; other site 264198017377 homodimer interface [polypeptide binding]; other site 264198017378 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 264198017379 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198017380 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 264198017381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017382 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198017383 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264198017384 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 264198017385 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 264198017386 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 264198017387 tetramer interface [polypeptide binding]; other site 264198017388 active site 264198017389 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 264198017390 heterodimer interface [polypeptide binding]; other site 264198017391 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 264198017392 active site 264198017393 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 264198017394 multimer interface [polypeptide binding]; other site 264198017395 heterodimer interface [polypeptide binding]; other site 264198017396 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 264198017397 active site 264198017398 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198017399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017401 dimerization interface [polypeptide binding]; other site 264198017402 benzoate transport; Region: 2A0115; TIGR00895 264198017403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017404 putative substrate translocation pore; other site 264198017405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017406 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 264198017407 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264198017408 dimer interface [polypeptide binding]; other site 264198017409 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264198017410 active site 264198017411 Fe binding site [ion binding]; other site 264198017412 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264198017413 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264198017414 NAD(P) binding site [chemical binding]; other site 264198017415 shikimate binding site; other site 264198017416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017417 D-galactonate transporter; Region: 2A0114; TIGR00893 264198017418 putative substrate translocation pore; other site 264198017419 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198017420 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017421 trimer interface [polypeptide binding]; other site 264198017422 eyelet of channel; other site 264198017423 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264198017424 Dehydroquinase class II; Region: DHquinase_II; pfam01220 264198017425 active site 264198017426 trimer interface [polypeptide binding]; other site 264198017427 dimer interface [polypeptide binding]; other site 264198017428 transcriptional activator TtdR; Provisional; Region: PRK09801 264198017429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017431 dimerization interface [polypeptide binding]; other site 264198017432 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198017433 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198017434 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198017435 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264198017436 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 264198017437 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264198017438 dimer interface [polypeptide binding]; other site 264198017439 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264198017440 active site 264198017441 Fe binding site [ion binding]; other site 264198017442 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198017443 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198017444 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 264198017445 acyl-activating enzyme (AAE) consensus motif; other site 264198017446 putative AMP binding site [chemical binding]; other site 264198017447 putative active site [active] 264198017448 putative CoA binding site [chemical binding]; other site 264198017449 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 264198017450 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 264198017451 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264198017452 DNA binding residues [nucleotide binding] 264198017453 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017455 active site 264198017456 phosphorylation site [posttranslational modification] 264198017457 intermolecular recognition site; other site 264198017458 dimerization interface [polypeptide binding]; other site 264198017459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017460 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198017461 putative active site [active] 264198017462 heme pocket [chemical binding]; other site 264198017463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017464 dimer interface [polypeptide binding]; other site 264198017465 phosphorylation site [posttranslational modification] 264198017466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017467 ATP binding site [chemical binding]; other site 264198017468 Mg2+ binding site [ion binding]; other site 264198017469 G-X-G motif; other site 264198017470 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017472 active site 264198017473 phosphorylation site [posttranslational modification] 264198017474 intermolecular recognition site; other site 264198017475 dimerization interface [polypeptide binding]; other site 264198017476 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198017477 putative binding surface; other site 264198017478 active site 264198017479 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 264198017480 active site residue [active] 264198017481 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 264198017482 active site residue [active] 264198017483 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 264198017484 active site residue [active] 264198017485 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 264198017486 active site residue [active] 264198017487 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 264198017488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017489 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198017490 active site 264198017491 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264198017492 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 264198017493 dimer interface [polypeptide binding]; other site 264198017494 active site 264198017495 non-prolyl cis peptide bond; other site 264198017496 insertion regions; other site 264198017497 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198017498 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198017499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017500 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198017501 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198017502 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198017503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198017504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017505 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198017506 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198017507 NAD(P) binding site [chemical binding]; other site 264198017508 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198017509 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198017510 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 264198017511 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 264198017512 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 264198017513 Hemerythrin-like domain; Region: Hr-like; cd12108 264198017514 Fe binding site [ion binding]; other site 264198017515 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 264198017516 GAF domain; Region: GAF; pfam01590 264198017517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017518 Walker A motif; other site 264198017519 ATP binding site [chemical binding]; other site 264198017520 Walker B motif; other site 264198017521 arginine finger; other site 264198017522 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264198017523 SCP-2 sterol transfer family; Region: SCP2; cl01225 264198017524 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264198017525 putative protease; Provisional; Region: PRK15447 264198017526 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264198017527 Peptidase family U32; Region: Peptidase_U32; pfam01136 264198017528 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198017529 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198017530 FMN binding site [chemical binding]; other site 264198017531 substrate binding site [chemical binding]; other site 264198017532 putative catalytic residue [active] 264198017533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198017534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198017535 ligand binding site [chemical binding]; other site 264198017536 flexible hinge region; other site 264198017537 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198017538 putative switch regulator; other site 264198017539 non-specific DNA interactions [nucleotide binding]; other site 264198017540 DNA binding site [nucleotide binding] 264198017541 sequence specific DNA binding site [nucleotide binding]; other site 264198017542 putative cAMP binding site [chemical binding]; other site 264198017543 Hemerythrin-like domain; Region: Hr-like; cd12108 264198017544 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 264198017545 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 264198017546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198017547 dimerization interface [polypeptide binding]; other site 264198017548 GAF domain; Region: GAF; pfam01590 264198017549 Histidine kinase; Region: HisKA_3; pfam07730 264198017550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017551 ATP binding site [chemical binding]; other site 264198017552 Mg2+ binding site [ion binding]; other site 264198017553 G-X-G motif; other site 264198017554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198017555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017556 active site 264198017557 phosphorylation site [posttranslational modification] 264198017558 intermolecular recognition site; other site 264198017559 dimerization interface [polypeptide binding]; other site 264198017560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198017561 DNA binding residues [nucleotide binding] 264198017562 dimerization interface [polypeptide binding]; other site 264198017563 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198017564 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198017565 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 264198017566 Low affinity iron permease; Region: Iron_permease; pfam04120 264198017567 BON domain; Region: BON; pfam04972 264198017568 PRC-barrel domain; Region: PRC; pfam05239 264198017569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198017570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198017571 dimer interface [polypeptide binding]; other site 264198017572 phosphorylation site [posttranslational modification] 264198017573 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 264198017574 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198017575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017576 active site 264198017577 phosphorylation site [posttranslational modification] 264198017578 intermolecular recognition site; other site 264198017579 dimerization interface [polypeptide binding]; other site 264198017580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017581 Walker A motif; other site 264198017582 ATP binding site [chemical binding]; other site 264198017583 Walker B motif; other site 264198017584 arginine finger; other site 264198017585 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198017586 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198017587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017588 Walker A motif; other site 264198017589 ATP binding site [chemical binding]; other site 264198017590 Walker B motif; other site 264198017591 arginine finger; other site 264198017592 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198017593 short chain dehydrogenase; Provisional; Region: PRK07109 264198017594 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 264198017595 putative NAD(P) binding site [chemical binding]; other site 264198017596 active site 264198017597 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264198017598 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 264198017599 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264198017600 active site 264198017601 DNA binding site [nucleotide binding] 264198017602 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264198017603 DNA binding site [nucleotide binding] 264198017604 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 264198017605 nucleotide binding site [chemical binding]; other site 264198017606 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017608 active site 264198017609 phosphorylation site [posttranslational modification] 264198017610 intermolecular recognition site; other site 264198017611 dimerization interface [polypeptide binding]; other site 264198017612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017613 PAS domain; Region: PAS_9; pfam13426 264198017614 putative active site [active] 264198017615 heme pocket [chemical binding]; other site 264198017616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198017617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017618 dimer interface [polypeptide binding]; other site 264198017619 phosphorylation site [posttranslational modification] 264198017620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017621 ATP binding site [chemical binding]; other site 264198017622 Mg2+ binding site [ion binding]; other site 264198017623 G-X-G motif; other site 264198017624 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017626 active site 264198017627 phosphorylation site [posttranslational modification] 264198017628 intermolecular recognition site; other site 264198017629 dimerization interface [polypeptide binding]; other site 264198017630 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264198017631 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 264198017632 putative DNA binding site [nucleotide binding]; other site 264198017633 putative homodimer interface [polypeptide binding]; other site 264198017634 BON domain; Region: BON; pfam04972 264198017635 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 264198017636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017637 putative substrate translocation pore; other site 264198017638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017639 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198017640 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198017641 dimer interface [polypeptide binding]; other site 264198017642 putative CheW interface [polypeptide binding]; other site 264198017643 Sm and related proteins; Region: Sm_like; cl00259 264198017644 heptamer interface [polypeptide binding]; other site 264198017645 Sm1 motif; other site 264198017646 hexamer interface [polypeptide binding]; other site 264198017647 RNA binding site [nucleotide binding]; other site 264198017648 Sm2 motif; other site 264198017649 flagellin; Validated; Region: PRK06819 264198017650 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264198017651 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264198017652 FlaG protein; Region: FlaG; pfam03646 264198017653 flagellar capping protein; Reviewed; Region: fliD; PRK08032 264198017654 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 264198017655 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264198017656 flagellar protein FliS; Validated; Region: fliS; PRK05685 264198017657 Flagellar protein FliT; Region: FliT; pfam05400 264198017658 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 264198017659 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 264198017660 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 264198017661 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 264198017662 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 264198017663 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 264198017664 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 264198017665 FliG C-terminal domain; Region: FliG_C; pfam01706 264198017666 flagellar assembly protein H; Validated; Region: fliH; PRK05687 264198017667 Flagellar assembly protein FliH; Region: FliH; pfam02108 264198017668 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 264198017669 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 264198017670 Walker A motif/ATP binding site; other site 264198017671 Walker B motif; other site 264198017672 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 264198017673 Flagellar FliJ protein; Region: FliJ; pfam02050 264198017674 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 264198017675 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 264198017676 Uncharacterized conserved protein [Function unknown]; Region: COG3791 264198017677 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198017678 Protein of unknown function (DUF938); Region: DUF938; pfam06080 264198017679 High potential iron-sulfur protein; Region: HIPIP; pfam01355 264198017680 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198017681 dimer interface [polypeptide binding]; other site 264198017682 putative CheW interface [polypeptide binding]; other site 264198017683 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 264198017684 Uncharacterized conserved protein [Function unknown]; Region: COG1739 264198017685 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 264198017686 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 264198017687 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198017688 catalytic loop [active] 264198017689 iron binding site [ion binding]; other site 264198017690 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 264198017691 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 264198017692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 264198017693 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198017694 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198017695 active site 264198017696 catalytic tetrad [active] 264198017697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017699 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 264198017700 putative effector binding pocket; other site 264198017701 dimerization interface [polypeptide binding]; other site 264198017702 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 264198017703 Peptidase M30; Region: Peptidase_M30; pfam10460 264198017704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017707 dimerization interface [polypeptide binding]; other site 264198017708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017709 D-galactonate transporter; Region: 2A0114; TIGR00893 264198017710 putative substrate translocation pore; other site 264198017711 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 264198017712 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 264198017713 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198017714 homotrimer interaction site [polypeptide binding]; other site 264198017715 putative active site [active] 264198017716 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198017717 classical (c) SDRs; Region: SDR_c; cd05233 264198017718 NAD(P) binding site [chemical binding]; other site 264198017719 active site 264198017720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017723 dimerization interface [polypeptide binding]; other site 264198017724 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198017725 FMN binding site [chemical binding]; other site 264198017726 substrate binding site [chemical binding]; other site 264198017727 putative catalytic residue [active] 264198017728 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 264198017729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198017730 Coenzyme A binding pocket [chemical binding]; other site 264198017731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198017732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198017733 non-specific DNA binding site [nucleotide binding]; other site 264198017734 salt bridge; other site 264198017735 sequence-specific DNA binding site [nucleotide binding]; other site 264198017736 Cupin domain; Region: Cupin_2; pfam07883 264198017737 aminopeptidase N; Provisional; Region: pepN; PRK14015 264198017738 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198017739 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198017740 DNA-binding site [nucleotide binding]; DNA binding site 264198017741 RNA-binding motif; other site 264198017742 HD domain; Region: HD_3; pfam13023 264198017743 Cache domain; Region: Cache_1; pfam02743 264198017744 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198017745 dimerization interface [polypeptide binding]; other site 264198017746 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198017747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198017748 dimer interface [polypeptide binding]; other site 264198017749 putative CheW interface [polypeptide binding]; other site 264198017750 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198017751 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017752 trimer interface [polypeptide binding]; other site 264198017753 eyelet of channel; other site 264198017754 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 264198017755 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198017756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198017757 DNA-binding site [nucleotide binding]; DNA binding site 264198017758 FCD domain; Region: FCD; pfam07729 264198017759 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 264198017760 homodimer interface [polypeptide binding]; other site 264198017761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198017762 catalytic residue [active] 264198017763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017764 D-galactonate transporter; Region: 2A0114; TIGR00893 264198017765 putative substrate translocation pore; other site 264198017766 amidase; Provisional; Region: PRK08137 264198017767 Amidase; Region: Amidase; cl11426 264198017768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198017770 putative substrate translocation pore; other site 264198017771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017772 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198017773 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198017774 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198017775 tricarballylate utilization protein B; Provisional; Region: PRK15033 264198017776 tricarballylate dehydrogenase; Validated; Region: PRK08274 264198017777 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198017778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017779 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198017780 putative dimerization interface [polypeptide binding]; other site 264198017781 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264198017782 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264198017783 putative dimer interface [polypeptide binding]; other site 264198017784 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264198017785 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264198017786 putative dimer interface [polypeptide binding]; other site 264198017787 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198017788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198017789 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198017790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 264198017791 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198017792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198017793 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198017794 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264198017795 classical (c) SDRs; Region: SDR_c; cd05233 264198017796 NAD(P) binding site [chemical binding]; other site 264198017797 active site 264198017798 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198017799 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198017800 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198017801 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198017802 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198017803 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 264198017804 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 264198017805 ApbE family; Region: ApbE; pfam02424 264198017806 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264198017807 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 264198017808 Flavodoxin; Region: Flavodoxin_1; pfam00258 264198017809 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 264198017810 FAD binding pocket [chemical binding]; other site 264198017811 FAD binding motif [chemical binding]; other site 264198017812 catalytic residues [active] 264198017813 NAD binding pocket [chemical binding]; other site 264198017814 phosphate binding motif [ion binding]; other site 264198017815 beta-alpha-beta structure motif; other site 264198017816 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 264198017817 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 264198017818 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198017819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017820 active site 264198017821 phosphorylation site [posttranslational modification] 264198017822 intermolecular recognition site; other site 264198017823 dimerization interface [polypeptide binding]; other site 264198017824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198017825 DNA binding site [nucleotide binding] 264198017826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198017827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198017828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017829 dimer interface [polypeptide binding]; other site 264198017830 phosphorylation site [posttranslational modification] 264198017831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017832 ATP binding site [chemical binding]; other site 264198017833 Mg2+ binding site [ion binding]; other site 264198017834 G-X-G motif; other site 264198017835 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264198017836 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 264198017837 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198017838 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198017839 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198017840 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264198017841 FtsX-like permease family; Region: FtsX; pfam02687 264198017842 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264198017843 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264198017844 Walker A/P-loop; other site 264198017845 ATP binding site [chemical binding]; other site 264198017846 Q-loop/lid; other site 264198017847 ABC transporter signature motif; other site 264198017848 Walker B; other site 264198017849 D-loop; other site 264198017850 H-loop/switch region; other site 264198017851 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198017852 Ligand Binding Site [chemical binding]; other site 264198017853 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 264198017854 benzoate transport; Region: 2A0115; TIGR00895 264198017855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017856 putative substrate translocation pore; other site 264198017857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017858 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 264198017859 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264198017860 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264198017861 GDP-binding site [chemical binding]; other site 264198017862 ACT binding site; other site 264198017863 IMP binding site; other site 264198017864 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198017865 homotrimer interaction site [polypeptide binding]; other site 264198017866 putative active site [active] 264198017867 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264198017868 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198017869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017870 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 264198017871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264198017872 substrate binding pocket [chemical binding]; other site 264198017873 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198017874 DNA-binding site [nucleotide binding]; DNA binding site 264198017875 RNA-binding motif; other site 264198017876 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264198017877 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264198017878 rRNA binding site [nucleotide binding]; other site 264198017879 predicted 30S ribosome binding site; other site 264198017880 CheB methylesterase; Region: CheB_methylest; pfam01339 264198017881 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264198017882 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264198017883 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 264198017884 PAS domain; Region: PAS_10; pfam13596 264198017885 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198017886 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264198017887 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264198017888 ring oligomerisation interface [polypeptide binding]; other site 264198017889 ATP/Mg binding site [chemical binding]; other site 264198017890 stacking interactions; other site 264198017891 hinge regions; other site 264198017892 FtsH Extracellular; Region: FtsH_ext; pfam06480 264198017893 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264198017894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017895 Walker A motif; other site 264198017896 ATP binding site [chemical binding]; other site 264198017897 Walker B motif; other site 264198017898 arginine finger; other site 264198017899 Peptidase family M41; Region: Peptidase_M41; pfam01434 264198017900 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264198017901 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 264198017902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017904 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198017905 putative effector binding pocket; other site 264198017906 dimerization interface [polypeptide binding]; other site 264198017907 Predicted periplasmic protein [Function unknown]; Region: COG3904 264198017908 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 264198017909 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 264198017910 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 264198017911 NAD binding site [chemical binding]; other site 264198017912 catalytic Zn binding site [ion binding]; other site 264198017913 substrate binding site [chemical binding]; other site 264198017914 structural Zn binding site [ion binding]; other site 264198017915 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 264198017916 PLD-like domain; Region: PLDc_2; pfam13091 264198017917 putative active site [active] 264198017918 catalytic site [active] 264198017919 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264198017920 PLD-like domain; Region: PLDc_2; pfam13091 264198017921 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264198017922 PLD-like domain; Region: PLDc_2; pfam13091 264198017923 putative active site [active] 264198017924 catalytic site [active] 264198017925 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198017926 CoA binding domain; Region: CoA_binding_2; pfam13380 264198017927 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264198017928 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264198017929 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198017930 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198017931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017932 NAD(P) binding site [chemical binding]; other site 264198017933 active site 264198017934 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017935 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198017936 active site 264198017937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198017938 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198017939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198017940 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 264198017941 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 264198017942 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 264198017943 Flavodoxin; Region: Flavodoxin_1; pfam00258 264198017944 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198017945 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 264198017946 FAD binding pocket [chemical binding]; other site 264198017947 FAD binding motif [chemical binding]; other site 264198017948 catalytic residues [active] 264198017949 NAD binding pocket [chemical binding]; other site 264198017950 phosphate binding motif [ion binding]; other site 264198017951 beta-alpha-beta structure motif; other site 264198017952 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 264198017953 ApbE family; Region: ApbE; pfam02424 264198017954 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 264198017955 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 264198017956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 264198017957 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 264198017958 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198017959 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017960 trimer interface [polypeptide binding]; other site 264198017961 eyelet of channel; other site 264198017962 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198017963 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 264198017964 metal binding site [ion binding]; metal-binding site 264198017965 putative dimer interface [polypeptide binding]; other site 264198017966 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 264198017967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264198017968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198017970 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198017971 putative dimerization interface [polypeptide binding]; other site 264198017972 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198017973 YCII-related domain; Region: YCII; cl00999 264198017974 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 264198017975 DctM-like transporters; Region: DctM; pfam06808 264198017976 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 264198017977 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 264198017978 trimer interface [polypeptide binding]; other site 264198017979 putative Zn binding site [ion binding]; other site 264198017980 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264198017981 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 264198017982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198017983 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 264198017984 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 264198017985 Chromate transporter; Region: Chromate_transp; pfam02417 264198017986 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 264198017987 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198017988 dimer interface [polypeptide binding]; other site 264198017989 putative CheW interface [polypeptide binding]; other site 264198017990 Predicted membrane protein [Function unknown]; Region: COG2261 264198017991 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 264198017992 Transglycosylase; Region: Transgly; cl17702 264198017993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264198017994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198017995 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198017996 active site 264198017997 catalytic tetrad [active] 264198017998 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 264198017999 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198018000 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 264198018001 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198018002 DXD motif; other site 264198018003 PilZ domain; Region: PilZ; pfam07238 264198018004 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198018005 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 264198018006 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 264198018007 putative active site [active] 264198018008 argininosuccinate synthase; Validated; Region: PRK05370 264198018009 argininosuccinate synthase; Provisional; Region: PRK13820 264198018010 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198018011 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198018012 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018013 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198018014 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198018015 substrate binding site [chemical binding]; other site 264198018016 oxyanion hole (OAH) forming residues; other site 264198018017 trimer interface [polypeptide binding]; other site 264198018018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018020 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198018021 putative dimerization interface [polypeptide binding]; other site 264198018022 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264198018023 dimer interface [polypeptide binding]; other site 264198018024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198018025 hypothetical protein; Provisional; Region: PRK04325 264198018026 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 264198018027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198018030 dimerization interface [polypeptide binding]; other site 264198018031 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018032 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 264198018033 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 264198018034 active site 264198018035 putative substrate binding pocket [chemical binding]; other site 264198018036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018037 NAD-dependent deacetylase; Provisional; Region: PRK05333 264198018038 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 264198018039 NAD+ binding site [chemical binding]; other site 264198018040 substrate binding site [chemical binding]; other site 264198018041 Zn binding site [ion binding]; other site 264198018042 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 264198018043 hypothetical protein; Provisional; Region: PRK10279 264198018044 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 264198018045 active site 264198018046 nucleophile elbow; other site 264198018047 Surface antigen; Region: Bac_surface_Ag; pfam01103 264198018048 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 264198018049 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 264198018050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018051 Walker A motif; other site 264198018052 ATP binding site [chemical binding]; other site 264198018053 Walker B motif; other site 264198018054 arginine finger; other site 264198018055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018056 Walker A motif; other site 264198018057 ATP binding site [chemical binding]; other site 264198018058 Walker B motif; other site 264198018059 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264198018060 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 264198018061 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198018062 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198018063 ligand binding site [chemical binding]; other site 264198018064 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 264198018065 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 264198018066 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 264198018067 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 264198018068 Protein of unknown function (DUF877); Region: DUF877; pfam05943 264198018069 Protein of unknown function (DUF770); Region: DUF770; pfam05591 264198018070 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 264198018071 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 264198018072 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264198018073 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 264198018074 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 264198018075 PGAP1-like protein; Region: PGAP1; pfam07819 264198018076 ADP-dependent glucokinase; Provisional; Region: PRK14039 264198018077 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 264198018078 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 264198018079 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 264198018080 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 264198018081 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 264198018082 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 264198018083 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 264198018084 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 264198018085 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 264198018086 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198018087 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198018088 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018089 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 264198018090 Cytochrome P450; Region: p450; cl12078 264198018091 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198018092 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198018093 FMN-binding pocket [chemical binding]; other site 264198018094 flavin binding motif; other site 264198018095 phosphate binding motif [ion binding]; other site 264198018096 beta-alpha-beta structure motif; other site 264198018097 NAD binding pocket [chemical binding]; other site 264198018098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018099 catalytic loop [active] 264198018100 iron binding site [ion binding]; other site 264198018101 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198018102 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 264198018103 NAD(P) binding site [chemical binding]; other site 264198018104 catalytic residues [active] 264198018105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018108 dimerization interface [polypeptide binding]; other site 264198018109 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 264198018110 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198018111 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198018112 lipid-transfer protein; Provisional; Region: PRK07855 264198018113 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198018114 active site 264198018115 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198018116 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198018117 substrate binding site [chemical binding]; other site 264198018118 oxyanion hole (OAH) forming residues; other site 264198018119 trimer interface [polypeptide binding]; other site 264198018120 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198018121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198018122 acyl-activating enzyme (AAE) consensus motif; other site 264198018123 AMP binding site [chemical binding]; other site 264198018124 active site 264198018125 CoA binding site [chemical binding]; other site 264198018126 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198018127 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198018128 active site 264198018129 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018130 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198018131 Phosphotransferase enzyme family; Region: APH; pfam01636 264198018132 putative active site [active] 264198018133 putative substrate binding site [chemical binding]; other site 264198018134 ATP binding site [chemical binding]; other site 264198018135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198018136 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198018137 active site 264198018138 short chain dehydrogenase; Provisional; Region: PRK06949 264198018139 classical (c) SDRs; Region: SDR_c; cd05233 264198018140 NAD(P) binding site [chemical binding]; other site 264198018141 active site 264198018142 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198018143 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198018144 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198018145 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198018146 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198018147 ligand binding site [chemical binding]; other site 264198018148 homodimer interface [polypeptide binding]; other site 264198018149 NAD(P) binding site [chemical binding]; other site 264198018150 trimer interface B [polypeptide binding]; other site 264198018151 trimer interface A [polypeptide binding]; other site 264198018152 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198018153 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198018154 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198018155 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198018156 NAD(P) binding site [chemical binding]; other site 264198018157 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198018158 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198018159 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 264198018160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018161 DNA-binding site [nucleotide binding]; DNA binding site 264198018162 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 264198018163 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198018164 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 264198018165 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198018166 dimer interface [polypeptide binding]; other site 264198018167 PYR/PP interface [polypeptide binding]; other site 264198018168 TPP binding site [chemical binding]; other site 264198018169 substrate binding site [chemical binding]; other site 264198018170 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198018171 TPP-binding site [chemical binding]; other site 264198018172 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264198018173 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018174 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018175 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198018176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018177 putative substrate translocation pore; other site 264198018178 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198018179 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198018180 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198018182 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198018183 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198018184 active site 264198018185 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198018186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198018187 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198018188 acyl-activating enzyme (AAE) consensus motif; other site 264198018189 acyl-activating enzyme (AAE) consensus motif; other site 264198018190 putative AMP binding site [chemical binding]; other site 264198018191 putative active site [active] 264198018192 putative CoA binding site [chemical binding]; other site 264198018193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018196 dimerization interface [polypeptide binding]; other site 264198018197 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198018198 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198018199 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018200 Flagellar regulator YcgR; Region: YcgR; pfam07317 264198018201 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 264198018202 PilZ domain; Region: PilZ; pfam07238 264198018203 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 264198018204 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264198018205 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264198018206 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264198018207 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264198018208 DNA binding site [nucleotide binding] 264198018209 active site 264198018210 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 264198018211 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 264198018212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198018213 AlkA N-terminal domain; Region: AlkA_N; pfam06029 264198018214 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 264198018215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198018216 minor groove reading motif; other site 264198018217 helix-hairpin-helix signature motif; other site 264198018218 substrate binding pocket [chemical binding]; other site 264198018219 active site 264198018220 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198018221 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264198018222 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198018223 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198018224 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198018225 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198018226 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198018227 active site 264198018228 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198018229 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198018230 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 264198018231 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198018232 MarR family; Region: MarR_2; pfam12802 264198018233 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198018234 hypothetical protein; Provisional; Region: PRK11770 264198018235 Domain of unknown function (DUF307); Region: DUF307; pfam03733 264198018236 Domain of unknown function (DUF307); Region: DUF307; pfam03733 264198018237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198018238 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 264198018239 dimer interface [polypeptide binding]; other site 264198018240 phosphorylation site [posttranslational modification] 264198018241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198018242 ATP binding site [chemical binding]; other site 264198018243 Mg2+ binding site [ion binding]; other site 264198018244 G-X-G motif; other site 264198018245 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264198018246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018247 active site 264198018248 phosphorylation site [posttranslational modification] 264198018249 intermolecular recognition site; other site 264198018250 dimerization interface [polypeptide binding]; other site 264198018251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198018252 DNA binding site [nucleotide binding] 264198018253 glucokinase; Provisional; Region: glk; PRK00292 264198018254 glucokinase, proteobacterial type; Region: glk; TIGR00749 264198018255 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 264198018256 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 264198018257 putative active site [active] 264198018258 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264198018259 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264198018260 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264198018261 phosphogluconate dehydratase; Validated; Region: PRK09054 264198018262 6-phosphogluconate dehydratase; Region: edd; TIGR01196 264198018263 mechanosensitive channel MscS; Provisional; Region: PRK10334 264198018264 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198018265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198018266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198018267 H+ Antiporter protein; Region: 2A0121; TIGR00900 264198018268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018269 putative substrate translocation pore; other site 264198018270 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264198018271 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 264198018272 G1 box; other site 264198018273 putative GEF interaction site [polypeptide binding]; other site 264198018274 GTP/Mg2+ binding site [chemical binding]; other site 264198018275 Switch I region; other site 264198018276 G2 box; other site 264198018277 G3 box; other site 264198018278 Switch II region; other site 264198018279 G4 box; other site 264198018280 G5 box; other site 264198018281 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264198018282 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 264198018283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018284 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198018285 Walker A motif; other site 264198018286 ATP binding site [chemical binding]; other site 264198018287 Walker B motif; other site 264198018288 arginine finger; other site 264198018289 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 264198018290 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264198018291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198018292 DNA-binding site [nucleotide binding]; DNA binding site 264198018293 RNA-binding motif; other site 264198018294 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 264198018295 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 264198018296 DNA-binding site [nucleotide binding]; DNA binding site 264198018297 RNA-binding motif; other site 264198018298 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264198018299 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198018300 P-loop; other site 264198018301 Magnesium ion binding site [ion binding]; other site 264198018302 ParB-like nuclease domain; Region: ParBc; pfam02195 264198018303 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264198018304 Phage integrase protein; Region: DUF3701; pfam12482 264198018305 PAS fold; Region: PAS_4; pfam08448 264198018306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018307 putative active site [active] 264198018308 heme pocket [chemical binding]; other site 264198018309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198018310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198018311 dimer interface [polypeptide binding]; other site 264198018312 phosphorylation site [posttranslational modification] 264198018313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198018314 ATP binding site [chemical binding]; other site 264198018315 Mg2+ binding site [ion binding]; other site 264198018316 G-X-G motif; other site 264198018317 Response regulator receiver domain; Region: Response_reg; pfam00072 264198018318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018319 active site 264198018320 phosphorylation site [posttranslational modification] 264198018321 intermolecular recognition site; other site 264198018322 dimerization interface [polypeptide binding]; other site 264198018323 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 264198018324 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 264198018325 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198018326 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264198018327 Probable Catalytic site; other site 264198018328 metal-binding site 264198018329 Benzoate membrane transport protein; Region: BenE; pfam03594 264198018330 benzoate transporter; Region: benE; TIGR00843 264198018331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198018333 DNA binding residues [nucleotide binding] 264198018334 dimerization interface [polypeptide binding]; other site 264198018335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264198018336 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 264198018337 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 264198018338 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198018339 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198018340 ligand binding site [chemical binding]; other site 264198018341 flexible hinge region; other site 264198018342 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198018343 non-specific DNA interactions [nucleotide binding]; other site 264198018344 DNA binding site [nucleotide binding] 264198018345 sequence specific DNA binding site [nucleotide binding]; other site 264198018346 putative cAMP binding site [chemical binding]; other site 264198018347 tyrosine kinase; Provisional; Region: PRK11519 264198018348 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 264198018349 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198018350 acyl carrier protein; Provisional; Region: PRK07081 264198018351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198018352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198018353 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 264198018354 dimer interface [polypeptide binding]; other site 264198018355 motif 1; other site 264198018356 active site 264198018357 motif 2; other site 264198018358 motif 3; other site 264198018359 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 264198018360 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 264198018361 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264198018362 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 264198018363 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264198018364 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264198018365 active site 264198018366 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264198018367 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264198018368 putative trimer interface [polypeptide binding]; other site 264198018369 putative CoA binding site [chemical binding]; other site 264198018370 tyrosine kinase; Provisional; Region: PRK11519 264198018371 Chain length determinant protein; Region: Wzz; pfam02706 264198018372 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 264198018373 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 264198018374 DTAP/Switch II; other site 264198018375 Switch I; other site 264198018376 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 264198018377 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264198018378 active site 264198018379 polysaccharide export protein Wza; Provisional; Region: PRK15078 264198018380 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264198018381 SLBB domain; Region: SLBB; pfam10531 264198018382 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264198018383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198018384 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 264198018385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198018386 putative ADP-binding pocket [chemical binding]; other site 264198018387 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 264198018388 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 264198018389 active site 264198018390 dimer interface [polypeptide binding]; other site 264198018391 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 264198018392 Ligand Binding Site [chemical binding]; other site 264198018393 Molecular Tunnel; other site 264198018394 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 264198018395 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 264198018396 NAD binding site [chemical binding]; other site 264198018397 substrate binding site [chemical binding]; other site 264198018398 homodimer interface [polypeptide binding]; other site 264198018399 active site 264198018400 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 264198018401 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264198018402 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 264198018403 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 264198018404 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264198018405 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264198018406 NAD(P) binding site [chemical binding]; other site 264198018407 homodimer interface [polypeptide binding]; other site 264198018408 substrate binding site [chemical binding]; other site 264198018409 active site 264198018410 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264198018411 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264198018412 inhibitor-cofactor binding pocket; inhibition site 264198018413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198018414 catalytic residue [active] 264198018415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 264198018416 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264198018417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264198018418 active site 264198018419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018420 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198018422 DNA binding residues [nucleotide binding] 264198018423 dimerization interface [polypeptide binding]; other site 264198018424 putative cyanate transporter; Provisional; Region: cynX; PRK09705 264198018425 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264198018426 nucleoside/Zn binding site; other site 264198018427 dimer interface [polypeptide binding]; other site 264198018428 catalytic motif [active] 264198018429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018432 dimerization interface [polypeptide binding]; other site 264198018433 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198018434 active site 264198018435 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 264198018436 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264198018437 substrate binding site [chemical binding]; other site 264198018438 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264198018439 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264198018440 substrate binding site [chemical binding]; other site 264198018441 ligand binding site [chemical binding]; other site 264198018442 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018443 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198018444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018445 DNA-binding site [nucleotide binding]; DNA binding site 264198018446 UTRA domain; Region: UTRA; pfam07702 264198018447 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 264198018448 putative active site [active] 264198018449 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198018450 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 264198018451 putative ligand binding site [chemical binding]; other site 264198018452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018454 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198018455 putative dimerization interface [polypeptide binding]; other site 264198018456 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 264198018457 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264198018459 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 264198018460 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 264198018461 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 264198018462 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 264198018463 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 264198018464 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 264198018465 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198018466 Response regulator receiver domain; Region: Response_reg; pfam00072 264198018467 AAA domain; Region: AAA_31; pfam13614 264198018468 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264198018469 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264198018470 ATP binding site [chemical binding]; other site 264198018471 Walker A motif; other site 264198018472 hexamer interface [polypeptide binding]; other site 264198018473 Walker B motif; other site 264198018474 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 264198018475 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198018476 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 264198018477 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264198018478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198018479 TPR motif; other site 264198018480 binding surface 264198018481 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 264198018482 Predicted membrane protein [Function unknown]; Region: COG4655 264198018483 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 264198018484 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 264198018485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018486 Walker A motif; other site 264198018487 ATP binding site [chemical binding]; other site 264198018488 Walker B motif; other site 264198018489 arginine finger; other site 264198018490 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198018491 Cytochrome c553 [Energy production and conversion]; Region: COG2863 264198018492 Cytochrome c; Region: Cytochrom_C; cl11414 264198018493 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198018494 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264198018495 Trp docking motif [polypeptide binding]; other site 264198018496 active site 264198018497 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264198018498 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198018499 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198018500 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 264198018501 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198018502 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264198018503 structural tetrad; other site 264198018504 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264198018505 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264198018506 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 264198018507 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 264198018508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264198018509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198018510 Coenzyme A binding pocket [chemical binding]; other site 264198018511 AMP nucleosidase; Provisional; Region: PRK08292 264198018512 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 264198018513 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 264198018514 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 264198018515 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 264198018516 ferrous iron transporter FeoB; Region: feoB; TIGR00437 264198018517 G1 box; other site 264198018518 GTP/Mg2+ binding site [chemical binding]; other site 264198018519 Switch I region; other site 264198018520 G2 box; other site 264198018521 G3 box; other site 264198018522 Switch II region; other site 264198018523 G4 box; other site 264198018524 G5 box; other site 264198018525 Nucleoside recognition; Region: Gate; pfam07670 264198018526 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264198018527 Nucleoside recognition; Region: Gate; pfam07670 264198018528 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 264198018529 MarR family; Region: MarR_2; cl17246 264198018530 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264198018531 active site 264198018532 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 264198018533 dimer interface [polypeptide binding]; other site 264198018534 non-prolyl cis peptide bond; other site 264198018535 insertion regions; other site 264198018536 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264198018537 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 264198018538 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198018539 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018540 trimer interface [polypeptide binding]; other site 264198018541 eyelet of channel; other site 264198018542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018543 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 264198018544 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 264198018545 putative dimerization interface [polypeptide binding]; other site 264198018546 putative substrate binding pocket [chemical binding]; other site 264198018547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198018548 active site 264198018549 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018550 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198018551 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198018552 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018553 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 264198018554 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264198018555 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 264198018556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018558 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198018559 putative dimerization interface [polypeptide binding]; other site 264198018560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198018561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018562 NAD(P) binding site [chemical binding]; other site 264198018563 active site 264198018564 L-lactate permease; Region: Lactate_perm; cl00701 264198018565 glycolate transporter; Provisional; Region: PRK09695 264198018566 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 264198018567 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264198018568 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198018569 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 264198018570 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 264198018571 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198018572 Cysteine-rich domain; Region: CCG; pfam02754 264198018573 Cysteine-rich domain; Region: CCG; pfam02754 264198018574 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198018575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018576 DNA-binding site [nucleotide binding]; DNA binding site 264198018577 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 264198018578 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 264198018579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018581 active site 264198018582 phosphorylation site [posttranslational modification] 264198018583 intermolecular recognition site; other site 264198018584 dimerization interface [polypeptide binding]; other site 264198018585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198018586 DNA binding residues [nucleotide binding] 264198018587 dimerization interface [polypeptide binding]; other site 264198018588 MASE1; Region: MASE1; cl17823 264198018589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264198018590 Histidine kinase; Region: HisKA_3; pfam07730 264198018591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198018592 ATP binding site [chemical binding]; other site 264198018593 Mg2+ binding site [ion binding]; other site 264198018594 G-X-G motif; other site 264198018595 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 264198018596 trimer interface [polypeptide binding]; other site 264198018597 putative Zn binding site [ion binding]; other site 264198018598 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 264198018599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018602 dimerization interface [polypeptide binding]; other site 264198018603 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198018604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 264198018605 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 264198018606 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198018607 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 264198018608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018609 NAD(P) binding site [chemical binding]; other site 264198018610 active site 264198018611 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198018612 classical (c) SDRs; Region: SDR_c; cd05233 264198018613 NAD(P) binding site [chemical binding]; other site 264198018614 active site 264198018615 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198018616 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198018617 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198018618 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 264198018619 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198018620 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 264198018621 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 264198018622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198018623 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 264198018624 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264198018625 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264198018626 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198018627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198018628 metal binding site [ion binding]; metal-binding site 264198018629 active site 264198018630 I-site; other site 264198018631 benzoate transport; Region: 2A0115; TIGR00895 264198018632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018633 putative substrate translocation pore; other site 264198018634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018635 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 264198018636 proline aminopeptidase P II; Provisional; Region: PRK10879 264198018637 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 264198018638 active site 264198018639 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198018640 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264198018641 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198018642 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198018643 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 264198018644 AAA ATPase domain; Region: AAA_16; pfam13191 264198018645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198018647 DNA binding residues [nucleotide binding] 264198018648 dimerization interface [polypeptide binding]; other site 264198018649 Avidin family; Region: Avidin; pfam01382 264198018650 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 264198018651 DNA binding residues [nucleotide binding] 264198018652 dimerization interface [polypeptide binding]; other site 264198018653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264198018654 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198018655 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 264198018656 benzoate transport; Region: 2A0115; TIGR00895 264198018657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018658 putative substrate translocation pore; other site 264198018659 hypothetical protein; Provisional; Region: PRK06847 264198018660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264198018661 hypothetical protein; Provisional; Region: PRK07236 264198018662 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198018663 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 264198018664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198018665 acyl-activating enzyme (AAE) consensus motif; other site 264198018666 AMP binding site [chemical binding]; other site 264198018667 active site 264198018668 CoA binding site [chemical binding]; other site 264198018669 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 264198018670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198018671 Zn binding site [ion binding]; other site 264198018672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198018673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198018674 PhoD-like phosphatase; Region: PhoD; pfam09423 264198018675 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264198018676 putative active site [active] 264198018677 putative metal binding site [ion binding]; other site 264198018678 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264198018679 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 264198018680 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 264198018681 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 264198018682 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 264198018683 putative deacylase active site [active] 264198018684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018686 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198018687 putative effector binding pocket; other site 264198018688 dimerization interface [polypeptide binding]; other site 264198018689 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 264198018690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018691 putative substrate translocation pore; other site 264198018692 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198018693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018695 dimerization interface [polypeptide binding]; other site 264198018696 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 264198018697 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 264198018698 NAD binding site [chemical binding]; other site 264198018699 catalytic residues [active] 264198018700 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018701 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018702 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198018703 homotrimer interaction site [polypeptide binding]; other site 264198018704 putative active site [active] 264198018705 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 264198018706 Amidohydrolase; Region: Amidohydro_2; pfam04909 264198018707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018709 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198018710 putative dimerization interface [polypeptide binding]; other site 264198018711 SnoaL-like domain; Region: SnoaL_4; pfam13577 264198018712 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 264198018713 active site 264198018714 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018715 hypothetical protein; Provisional; Region: PRK08204 264198018716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018717 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018718 active site 264198018719 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198018720 homotrimer interaction site [polypeptide binding]; other site 264198018721 putative active site [active] 264198018722 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198018723 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018724 trimer interface [polypeptide binding]; other site 264198018725 eyelet of channel; other site 264198018726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198018729 dimerization interface [polypeptide binding]; other site 264198018730 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018731 Uncharacterized conserved protein [Function unknown]; Region: COG5476 264198018732 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 264198018733 MlrC C-terminus; Region: MlrC_C; pfam07171 264198018734 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198018735 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 264198018736 fumarate hydratase; Reviewed; Region: fumC; PRK00485 264198018737 Class II fumarases; Region: Fumarase_classII; cd01362 264198018738 active site 264198018739 tetramer interface [polypeptide binding]; other site 264198018740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018741 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198018742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198018743 dimerization interface [polypeptide binding]; other site 264198018744 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 264198018745 dimerization interface [polypeptide binding]; other site 264198018746 Cache domain; Region: Cache_1; pfam02743 264198018747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198018748 PAS fold; Region: PAS_4; pfam08448 264198018749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018750 putative active site [active] 264198018751 heme pocket [chemical binding]; other site 264198018752 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198018753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198018754 metal binding site [ion binding]; metal-binding site 264198018755 active site 264198018756 I-site; other site 264198018757 CHASE domain; Region: CHASE; pfam03924 264198018758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018759 PAS domain; Region: PAS_9; pfam13426 264198018760 putative active site [active] 264198018761 PAS domain S-box; Region: sensory_box; TIGR00229 264198018762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018763 putative active site [active] 264198018764 heme pocket [chemical binding]; other site 264198018765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 264198018766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198018767 metal binding site [ion binding]; metal-binding site 264198018768 active site 264198018769 I-site; other site 264198018770 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198018771 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 264198018772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198018773 Walker A/P-loop; other site 264198018774 ATP binding site [chemical binding]; other site 264198018775 Q-loop/lid; other site 264198018776 ABC transporter signature motif; other site 264198018777 Walker B; other site 264198018778 D-loop; other site 264198018779 H-loop/switch region; other site 264198018780 TOBE domain; Region: TOBE_2; pfam08402 264198018781 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 264198018782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198018783 dimer interface [polypeptide binding]; other site 264198018784 conserved gate region; other site 264198018785 ABC-ATPase subunit interface; other site 264198018786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198018787 dimer interface [polypeptide binding]; other site 264198018788 conserved gate region; other site 264198018789 putative PBP binding loops; other site 264198018790 ABC-ATPase subunit interface; other site 264198018791 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 264198018792 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 264198018793 Predicted transcriptional regulators [Transcription]; Region: COG1695 264198018794 Transcriptional regulator PadR-like family; Region: PadR; cl17335 264198018795 EamA-like transporter family; Region: EamA; pfam00892 264198018796 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198018797 EamA-like transporter family; Region: EamA; pfam00892 264198018798 ferric uptake regulator; Provisional; Region: fur; PRK09462 264198018799 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264198018800 metal binding site 2 [ion binding]; metal-binding site 264198018801 putative DNA binding helix; other site 264198018802 metal binding site 1 [ion binding]; metal-binding site 264198018803 dimer interface [polypeptide binding]; other site 264198018804 structural Zn2+ binding site [ion binding]; other site 264198018805 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 264198018806 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198018807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198018808 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198018809 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264198018810 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198018811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018813 dimerization interface [polypeptide binding]; other site 264198018814 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 264198018815 elongation factor G; Reviewed; Region: PRK00007 264198018816 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264198018817 G1 box; other site 264198018818 putative GEF interaction site [polypeptide binding]; other site 264198018819 GTP/Mg2+ binding site [chemical binding]; other site 264198018820 Switch I region; other site 264198018821 G2 box; other site 264198018822 G3 box; other site 264198018823 Switch II region; other site 264198018824 G4 box; other site 264198018825 G5 box; other site 264198018826 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264198018827 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264198018828 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264198018829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018831 active site 264198018832 phosphorylation site [posttranslational modification] 264198018833 intermolecular recognition site; other site 264198018834 dimerization interface [polypeptide binding]; other site 264198018835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198018836 DNA binding residues [nucleotide binding] 264198018837 dimerization interface [polypeptide binding]; other site 264198018838 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264198018839 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 264198018840 active site residue [active] 264198018841 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 264198018842 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198018843 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018844 trimer interface [polypeptide binding]; other site 264198018845 eyelet of channel; other site 264198018846 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 264198018847 active site pocket [active] 264198018848 oxyanion hole [active] 264198018849 catalytic triad [active] 264198018850 active site nucleophile [active] 264198018851 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264198018852 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198018853 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198018854 catalytic residue [active] 264198018855 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198018856 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198018857 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198018858 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198018859 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018860 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264198018861 active site 264198018862 nucleophile elbow; other site 264198018863 AzlC protein; Region: AzlC; cl00570 264198018864 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198018865 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198018866 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018867 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 264198018868 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198018869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 264198018870 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 264198018871 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264198018872 HAMP domain; Region: HAMP; pfam00672 264198018873 dimerization interface [polypeptide binding]; other site 264198018874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198018875 dimer interface [polypeptide binding]; other site 264198018876 putative CheW interface [polypeptide binding]; other site 264198018877 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198018878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018879 Walker A motif; other site 264198018880 ATP binding site [chemical binding]; other site 264198018881 Walker B motif; other site 264198018882 arginine finger; other site 264198018883 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264198018884 DNA-binding interface [nucleotide binding]; DNA binding site 264198018885 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 264198018886 ATP-NAD kinase; Region: NAD_kinase; pfam01513 264198018887 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 264198018888 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264198018889 tetramer interface [polypeptide binding]; other site 264198018890 TPP-binding site [chemical binding]; other site 264198018891 heterodimer interface [polypeptide binding]; other site 264198018892 phosphorylation loop region [posttranslational modification] 264198018893 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264198018894 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 264198018895 alpha subunit interface [polypeptide binding]; other site 264198018896 TPP binding site [chemical binding]; other site 264198018897 heterodimer interface [polypeptide binding]; other site 264198018898 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198018899 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 264198018900 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198018901 E3 interaction surface; other site 264198018902 lipoyl attachment site [posttranslational modification]; other site 264198018903 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 264198018904 catalytic site [active] 264198018905 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264198018906 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 264198018907 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 264198018908 O-methyltransferase; Region: Methyltransf_2; pfam00891 264198018909 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 264198018910 GIY-YIG motif/motif A; other site 264198018911 putative active site [active] 264198018912 putative metal binding site [ion binding]; other site 264198018913 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 264198018914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198018915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198018916 putative Zn2+ binding site [ion binding]; other site 264198018917 putative DNA binding site [nucleotide binding]; other site 264198018918 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264198018919 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264198018920 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198018921 protein binding site [polypeptide binding]; other site 264198018922 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198018923 protein binding site [polypeptide binding]; other site 264198018924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018925 putative substrate translocation pore; other site 264198018926 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198018927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018928 MarR family; Region: MarR_2; cl17246 264198018929 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198018930 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 264198018931 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198018932 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264198018933 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 264198018934 Protein of unknown function DUF58; Region: DUF58; pfam01882 264198018935 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198018936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018937 Walker A motif; other site 264198018938 ATP binding site [chemical binding]; other site 264198018939 Walker B motif; other site 264198018940 arginine finger; other site 264198018941 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 264198018942 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198018943 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 264198018944 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018945 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198018946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018947 putative substrate translocation pore; other site 264198018948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198018950 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198018951 putative effector binding pocket; other site 264198018952 dimerization interface [polypeptide binding]; other site 264198018953 YGGT family; Region: YGGT; pfam02325 264198018954 YGGT family; Region: YGGT; pfam02325 264198018955 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198018956 MarR family; Region: MarR_2; pfam12802 264198018957 acyl-CoA synthetase; Validated; Region: PRK08316 264198018958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264198018959 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 264198018960 acyl-activating enzyme (AAE) consensus motif; other site 264198018961 acyl-activating enzyme (AAE) consensus motif; other site 264198018962 putative AMP binding site [chemical binding]; other site 264198018963 putative active site [active] 264198018964 putative CoA binding site [chemical binding]; other site 264198018965 Dienelactone hydrolase family; Region: DLH; pfam01738 264198018966 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 264198018967 PLD-like domain; Region: PLDc_2; pfam13091 264198018968 putative active site [active] 264198018969 catalytic site [active] 264198018970 Dodecin; Region: Dodecin; pfam07311 264198018971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 264198018972 FIST N domain; Region: FIST; smart00897 264198018973 FIST C domain; Region: FIST_C; pfam10442 264198018974 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 264198018975 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 264198018976 active site 264198018977 metal binding site [ion binding]; metal-binding site 264198018978 DNA binding site [nucleotide binding] 264198018979 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 264198018980 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 264198018981 AAA domain; Region: AAA_23; pfam13476 264198018982 Walker A/P-loop; other site 264198018983 ATP binding site [chemical binding]; other site 264198018984 Q-loop/lid; other site 264198018985 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 264198018986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198018987 ABC transporter signature motif; other site 264198018988 Walker B; other site 264198018989 D-loop; other site 264198018990 H-loop/switch region; other site 264198018991 Coenzyme A transferase; Region: CoA_trans; cl17247 264198018992 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 264198018993 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 264198018994 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198018995 dimer interface [polypeptide binding]; other site 264198018996 active site 264198018997 short chain dehydrogenase; Provisional; Region: PRK07577 264198018998 classical (c) SDRs; Region: SDR_c; cd05233 264198018999 NAD(P) binding site [chemical binding]; other site 264198019000 active site 264198019001 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198019002 Predicted transcriptional regulators [Transcription]; Region: COG1695 264198019003 Transcriptional regulator PadR-like family; Region: PadR; cl17335 264198019004 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 264198019005 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198019006 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198019007 FMN binding site [chemical binding]; other site 264198019008 substrate binding site [chemical binding]; other site 264198019009 putative catalytic residue [active] 264198019010 SnoaL-like domain; Region: SnoaL_2; pfam12680 264198019011 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264198019012 Int/Topo IB signature motif; other site 264198019013 DNA binding site [nucleotide binding] 264198019014 active site 264198019015 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 264198019016 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264198019017 NAD binding site [chemical binding]; other site 264198019018 homodimer interface [polypeptide binding]; other site 264198019019 active site 264198019020 substrate binding site [chemical binding]; other site 264198019021 H-NS histone family; Region: Histone_HNS; pfam00816 264198019022 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 264198019023 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198019024 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 264198019025 dimer interface [polypeptide binding]; other site 264198019026 ligand binding site [chemical binding]; other site 264198019027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198019028 dimerization interface [polypeptide binding]; other site 264198019029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198019030 dimer interface [polypeptide binding]; other site 264198019031 putative CheW interface [polypeptide binding]; other site 264198019032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198019033 metal binding site [ion binding]; metal-binding site 264198019034 active site 264198019035 I-site; other site 264198019036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198019037 Response regulator receiver domain; Region: Response_reg; pfam00072 264198019038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198019039 active site 264198019040 phosphorylation site [posttranslational modification] 264198019041 intermolecular recognition site; other site 264198019042 dimerization interface [polypeptide binding]; other site 264198019043 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 264198019044 putative CheA interaction surface; other site 264198019045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198019046 PAS fold; Region: PAS_3; pfam08447 264198019047 putative active site [active] 264198019048 heme pocket [chemical binding]; other site 264198019049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198019050 dimerization interface [polypeptide binding]; other site 264198019051 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198019052 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198019053 dimer interface [polypeptide binding]; other site 264198019054 putative CheW interface [polypeptide binding]; other site 264198019055 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198019056 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198019057 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198019058 dimer interface [polypeptide binding]; other site 264198019059 putative CheW interface [polypeptide binding]; other site 264198019060 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 264198019061 transcriptional activator FlhD; Provisional; Region: PRK02909 264198019062 transcriptional activator FlhC; Provisional; Region: PRK12722 264198019063 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 264198019064 flagellar motor protein MotA; Validated; Region: PRK09110 264198019065 flagellar motor protein MotB; Validated; Region: motB; PRK09041 264198019066 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264198019067 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198019068 ligand binding site [chemical binding]; other site 264198019069 chemotaxis protein CheA; Provisional; Region: PRK10547 264198019070 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198019071 putative binding surface; other site 264198019072 active site 264198019073 CheY binding; Region: CheY-binding; pfam09078 264198019074 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264198019075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198019076 ATP binding site [chemical binding]; other site 264198019077 Mg2+ binding site [ion binding]; other site 264198019078 G-X-G motif; other site 264198019079 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 264198019080 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198019081 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 264198019082 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264198019083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198019084 S-adenosylmethionine binding site [chemical binding]; other site 264198019085 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 264198019086 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264198019087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198019088 active site 264198019089 phosphorylation site [posttranslational modification] 264198019090 intermolecular recognition site; other site 264198019091 dimerization interface [polypeptide binding]; other site 264198019092 CheB methylesterase; Region: CheB_methylest; pfam01339 264198019093 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 264198019094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198019095 active site 264198019096 phosphorylation site [posttranslational modification] 264198019097 intermolecular recognition site; other site 264198019098 dimerization interface [polypeptide binding]; other site 264198019099 chemotaxis regulator CheZ; Provisional; Region: PRK11166 264198019100 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 264198019101 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 264198019102 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 264198019103 FHIPEP family; Region: FHIPEP; pfam00771 264198019104 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 264198019105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198019106 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198019107 Walker A/P-loop; other site 264198019108 ATP binding site [chemical binding]; other site 264198019109 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264198019110 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198019111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198019112 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 264198019113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198019114 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198019115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198019116 DNA binding residues [nucleotide binding] 264198019117 Flagellar protein FlhE; Region: FlhE; pfam06366 264198019118 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 264198019119 FlgN protein; Region: FlgN; pfam05130 264198019120 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 264198019121 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 264198019122 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264198019123 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 264198019124 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 264198019125 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 264198019126 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264198019127 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264198019128 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 264198019129 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 264198019130 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 264198019131 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 264198019132 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264198019133 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 264198019134 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264198019135 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 264198019136 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264198019137 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 264198019138 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 264198019139 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 264198019140 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264198019141 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 264198019142 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 264198019143 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 264198019144 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 264198019145 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 264198019146 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 264198019147 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 264198019148 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 264198019149 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 264198019150 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 264198019151 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264198019152 urocanate hydratase; Provisional; Region: PRK05414 264198019153 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264198019154 active sites [active] 264198019155 tetramer interface [polypeptide binding]; other site 264198019156 putative proline-specific permease; Provisional; Region: proY; PRK10580 264198019157 Spore germination protein; Region: Spore_permease; cl17796 264198019158 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198019159 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198019160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264198019161 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198019162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198019163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198019164 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198019165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198019166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198019167 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198019168 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198019169 Na binding site [ion binding]; other site 264198019170 Protein of unknown function, DUF485; Region: DUF485; pfam04341 264198019171 hypothetical protein; Provisional; Region: PRK07236 264198019172 hypothetical protein; Provisional; Region: PRK06847 264198019173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198019174 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 264198019175 dimer interface [polypeptide binding]; other site 264198019176 putative metal binding site [ion binding]; other site 264198019177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019179 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198019180 putative effector binding pocket; other site 264198019181 dimerization interface [polypeptide binding]; other site 264198019182 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198019183 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 264198019184 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 264198019185 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198019186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019187 putative substrate translocation pore; other site 264198019188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019189 transcriptional activator TtdR; Provisional; Region: PRK09801 264198019190 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 264198019191 putative effector binding pocket; other site 264198019192 putative dimerization interface [polypeptide binding]; other site 264198019193 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198019194 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198019195 putative membrane fusion protein; Region: TIGR02828 264198019196 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264198019197 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264198019198 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198019199 FAD binding domain; Region: FAD_binding_4; pfam01565 264198019200 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264198019201 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 264198019202 succinic semialdehyde dehydrogenase; Region: PLN02278 264198019203 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198019204 tetramerization interface [polypeptide binding]; other site 264198019205 NAD(P) binding site [chemical binding]; other site 264198019206 catalytic residues [active] 264198019207 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 264198019208 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 264198019209 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 264198019210 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264198019211 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 264198019212 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 264198019213 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198019214 inhibitor-cofactor binding pocket; inhibition site 264198019215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198019216 catalytic residue [active] 264198019217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019218 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198019219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019220 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198019221 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198019222 dimerization interface [polypeptide binding]; other site 264198019223 ligand binding site [chemical binding]; other site 264198019224 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198019225 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264198019226 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 264198019227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198019228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198019229 Amidohydrolase; Region: Amidohydro_4; pfam13147 264198019230 active site 264198019231 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198019232 EamA-like transporter family; Region: EamA; pfam00892 264198019233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198019234 DNA-binding site [nucleotide binding]; DNA binding site 264198019235 FCD domain; Region: FCD; pfam07729 264198019236 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264198019237 V4R domain; Region: V4R; pfam02830 264198019238 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198019239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198019240 Walker A motif; other site 264198019241 ATP binding site [chemical binding]; other site 264198019242 Walker B motif; other site 264198019243 arginine finger; other site 264198019244 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198019245 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 264198019246 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264198019247 V4R domain; Region: V4R; pfam02830 264198019248 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 264198019249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198019250 Walker A motif; other site 264198019251 ATP binding site [chemical binding]; other site 264198019252 Walker B motif; other site 264198019253 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264198019254 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198019255 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198019256 catalytic loop [active] 264198019257 iron binding site [ion binding]; other site 264198019258 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 264198019259 FAD binding pocket [chemical binding]; other site 264198019260 FAD binding motif [chemical binding]; other site 264198019261 phosphate binding motif [ion binding]; other site 264198019262 beta-alpha-beta structure motif; other site 264198019263 NAD binding pocket [chemical binding]; other site 264198019264 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 264198019265 dimerization interface [polypeptide binding]; other site 264198019266 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 264198019267 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 264198019268 [2Fe-2S] cluster binding site [ion binding]; other site 264198019269 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 264198019270 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198019271 dinuclear metal binding motif [ion binding]; other site 264198019272 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 264198019273 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198019274 dinuclear metal binding motif [ion binding]; other site 264198019275 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 264198019276 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 264198019277 dimerization interface [polypeptide binding]; other site 264198019278 putative path to active site cavity [active] 264198019279 diiron center [ion binding]; other site 264198019280 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 264198019281 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198019282 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198019283 catalytic loop [active] 264198019284 iron binding site [ion binding]; other site 264198019285 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198019286 FAD binding pocket [chemical binding]; other site 264198019287 conserved FAD binding motif [chemical binding]; other site 264198019288 phosphate binding motif [ion binding]; other site 264198019289 beta-alpha-beta structure motif; other site 264198019290 NAD binding pocket [chemical binding]; other site 264198019291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198019292 catalytic loop [active] 264198019293 iron binding site [ion binding]; other site 264198019294 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 264198019295 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 264198019296 tetramer interface [polypeptide binding]; other site 264198019297 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 264198019298 tetramer interface [polypeptide binding]; other site 264198019299 active site 264198019300 Fe binding site [ion binding]; other site 264198019301 Domain of unknown function (DUF336); Region: DUF336; pfam03928 264198019302 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 264198019303 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 264198019304 NAD binding site [chemical binding]; other site 264198019305 catalytic residues [active] 264198019306 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 264198019307 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 264198019308 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 264198019309 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 264198019310 active site 1 [active] 264198019311 dimer interface [polypeptide binding]; other site 264198019312 hexamer interface [polypeptide binding]; other site 264198019313 active site 2 [active] 264198019314 EthD domain; Region: EthD; cl17553 264198019315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019317 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198019318 dimerization interface [polypeptide binding]; other site 264198019319 substrate binding pocket [chemical binding]; other site 264198019320 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198019321 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 264198019322 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 264198019323 Uncharacterized conserved protein [Function unknown]; Region: COG3339 264198019324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198019325 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264198019326 dimerization domain swap beta strand [polypeptide binding]; other site 264198019327 regulatory protein interface [polypeptide binding]; other site 264198019328 active site 264198019329 regulatory phosphorylation site [posttranslational modification]; other site 264198019330 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 264198019331 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 264198019332 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198019333 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198019334 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 264198019335 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 264198019336 Na binding site [ion binding]; other site 264198019337 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 264198019338 agmatinase; Region: agmatinase; TIGR01230 264198019339 oligomer interface [polypeptide binding]; other site 264198019340 putative active site [active] 264198019341 Mn binding site [ion binding]; other site 264198019342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198019345 dimerization interface [polypeptide binding]; other site 264198019346 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 264198019347 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 264198019348 SEC-C motif; Region: SEC-C; pfam02810 264198019349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198019350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 264198019351 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198019352 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198019353 trimer interface [polypeptide binding]; other site 264198019354 eyelet of channel; other site 264198019355 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 264198019356 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264198019357 homotrimer interaction site [polypeptide binding]; other site 264198019358 putative active site [active] 264198019359 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 264198019360 benzoate transport; Region: 2A0115; TIGR00895 264198019361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019362 putative substrate translocation pore; other site 264198019363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019364 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 264198019365 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 264198019366 molybdopterin cofactor binding site [chemical binding]; other site 264198019367 substrate binding site [chemical binding]; other site 264198019368 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 264198019369 molybdopterin cofactor binding site; other site 264198019370 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198019371 Phosphotransferase enzyme family; Region: APH; pfam01636 264198019372 putative active site [active] 264198019373 putative substrate binding site [chemical binding]; other site 264198019374 ATP binding site [chemical binding]; other site 264198019375 short chain dehydrogenase; Provisional; Region: PRK07035 264198019376 classical (c) SDRs; Region: SDR_c; cd05233 264198019377 NAD(P) binding site [chemical binding]; other site 264198019378 active site 264198019379 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 264198019380 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198019381 ligand binding site [chemical binding]; other site 264198019382 homodimer interface [polypeptide binding]; other site 264198019383 NAD(P) binding site [chemical binding]; other site 264198019384 trimer interface B [polypeptide binding]; other site 264198019385 trimer interface A [polypeptide binding]; other site 264198019386 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198019387 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 264198019388 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198019389 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 264198019390 putative hydrophobic ligand binding site [chemical binding]; other site 264198019391 HTH-like domain; Region: HTH_21; pfam13276 264198019392 Integrase core domain; Region: rve; pfam00665 264198019393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198019394 putative acyl-acceptor binding pocket; other site 264198019395 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264198019396 Protein required for attachment to host cells; Region: Host_attach; cl02398 264198019397 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 264198019398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 264198019399 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 264198019400 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198019401 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264198019402 rRNA binding site [nucleotide binding]; other site 264198019403 predicted 30S ribosome binding site; other site 264198019404 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198019405 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 264198019406 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198019407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019409 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198019410 dimerization interface [polypeptide binding]; other site 264198019411 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 264198019412 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264198019413 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198019414 Na binding site [ion binding]; other site 264198019415 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 264198019416 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 264198019417 active site 264198019418 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198019419 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 264198019420 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 264198019421 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 264198019422 ornithine cyclodeaminase; Validated; Region: PRK06141 264198019423 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 264198019424 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198019425 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 264198019426 putative [Fe4-S4] binding site [ion binding]; other site 264198019427 putative molybdopterin cofactor binding site [chemical binding]; other site 264198019428 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198019429 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 264198019430 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 264198019431 putative molybdopterin cofactor binding site; other site 264198019432 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198019433 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 264198019434 FAD binding pocket [chemical binding]; other site 264198019435 FAD binding motif [chemical binding]; other site 264198019436 phosphate binding motif [ion binding]; other site 264198019437 beta-alpha-beta structure motif; other site 264198019438 NAD binding pocket [chemical binding]; other site 264198019439 Heme binding pocket [chemical binding]; other site 264198019440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198019441 catalytic loop [active] 264198019442 iron binding site [ion binding]; other site 264198019443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019445 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 264198019446 putative substrate binding pocket [chemical binding]; other site 264198019447 dimerization interface [polypeptide binding]; other site 264198019448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019450 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198019451 putative dimerization interface [polypeptide binding]; other site 264198019452 choline-sulfatase; Region: chol_sulfatase; TIGR03417 264198019453 Sulfatase; Region: Sulfatase; cl17466 264198019454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198019455 FAD binding domain; Region: FAD_binding_4; pfam01565 264198019456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198019457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019458 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198019459 putative substrate translocation pore; other site 264198019460 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264198019461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198019462 DNA-binding site [nucleotide binding]; DNA binding site 264198019463 FCD domain; Region: FCD; pfam07729 264198019464 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198019465 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198019466 trimer interface [polypeptide binding]; other site 264198019467 eyelet of channel; other site 264198019468 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 264198019469 Dienelactone hydrolase family; Region: DLH; pfam01738 264198019470 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198019471 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 264198019472 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 264198019473 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate; Region: 3MGA_Dioxygenase; cd07366 264198019474 putative active site [active] 264198019475 putative Fe(II) binding site [ion binding]; other site 264198019476 putative dimer interface [polypeptide binding]; other site 264198019477 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 264198019478 putative tetramer interface [polypeptide binding]; other site 264198019479 Amidohydrolase; Region: Amidohydro_2; pfam04909 264198019480 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198019481 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198019482 FMN-binding pocket [chemical binding]; other site 264198019483 flavin binding motif; other site 264198019484 phosphate binding motif [ion binding]; other site 264198019485 beta-alpha-beta structure motif; other site 264198019486 NAD binding pocket [chemical binding]; other site 264198019487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198019488 catalytic loop [active] 264198019489 iron binding site [ion binding]; other site 264198019490 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264198019491 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 264198019492 Asp-box motif; other site 264198019493 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198019494 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198019495 active site 264198019496 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198019497 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198019498 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198019499 alpha subunit interface [polypeptide binding]; other site 264198019500 active site 264198019501 substrate binding site [chemical binding]; other site 264198019502 Fe binding site [ion binding]; other site 264198019503 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198019504 Amidohydrolase; Region: Amidohydro_2; pfam04909 264198019505 active site 264198019506 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198019507 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198019508 NAD(P) binding site [chemical binding]; other site 264198019509 Amidohydrolase; Region: Amidohydro_2; pfam04909 264198019510 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198019511 active site 264198019512 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198019513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198019514 DNA-binding site [nucleotide binding]; DNA binding site 264198019515 FCD domain; Region: FCD; cl11656 264198019516 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198019517 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198019518 trimer interface [polypeptide binding]; other site 264198019519 eyelet of channel; other site 264198019520 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198019521 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198019522 iron-sulfur cluster [ion binding]; other site 264198019523 [2Fe-2S] cluster binding site [ion binding]; other site 264198019524 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198019525 alpha subunit interface [polypeptide binding]; other site 264198019526 active site 264198019527 substrate binding site [chemical binding]; other site 264198019528 Fe binding site [ion binding]; other site 264198019529 hypothetical protein; Validated; Region: PRK07121 264198019530 Predicted oxidoreductase [General function prediction only]; Region: COG3573 264198019531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198019533 putative substrate translocation pore; other site 264198019534 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198019535 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 264198019536 active site 264198019537 H+ Antiporter protein; Region: 2A0121; TIGR00900 264198019538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019540 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198019541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198019542 DNA-binding site [nucleotide binding]; DNA binding site 264198019543 NMT1-like family; Region: NMT1_2; pfam13379 264198019544 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198019545 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198019546 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264198019547 Walker A/P-loop; other site 264198019548 ATP binding site [chemical binding]; other site 264198019549 Q-loop/lid; other site 264198019550 ABC transporter signature motif; other site 264198019551 Walker B; other site 264198019552 D-loop; other site 264198019553 H-loop/switch region; other site 264198019554 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198019555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198019556 dimer interface [polypeptide binding]; other site 264198019557 conserved gate region; other site 264198019558 putative PBP binding loops; other site 264198019559 ABC-ATPase subunit interface; other site 264198019560 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 264198019561 Cupin domain; Region: Cupin_2; pfam07883 264198019562 Cupin domain; Region: Cupin_2; cl17218 264198019563 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198019564 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198019565 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264198019566 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264198019567 C-terminal domain interface [polypeptide binding]; other site 264198019568 GSH binding site (G-site) [chemical binding]; other site 264198019569 putative dimer interface [polypeptide binding]; other site 264198019570 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264198019571 dimer interface [polypeptide binding]; other site 264198019572 N-terminal domain interface [polypeptide binding]; other site 264198019573 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264198019574 salicylate hydroxylase; Provisional; Region: PRK08163 264198019575 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198019576 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264198019577 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 264198019578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198019579 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 264198019580 active site 264198019581 metal binding site [ion binding]; metal-binding site 264198019582 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 264198019583 TrkA-N domain; Region: TrkA_N; pfam02254 264198019584 hypothetical protein; Provisional; Region: PRK07236 264198019585 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198019586 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 264198019587 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198019588 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198019589 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198019590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198019591 putative DNA binding site [nucleotide binding]; other site 264198019592 putative Zn2+ binding site [ion binding]; other site 264198019593 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198019594 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 264198019595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019596 LysR substrate binding domain; Region: LysR_substrate; pfam03466 264198019597 dimerization interface [polypeptide binding]; other site 264198019598 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198019599 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198019600 metal binding site [ion binding]; metal-binding site 264198019601 putative dimer interface [polypeptide binding]; other site 264198019602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019603 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198019604 putative substrate translocation pore; other site 264198019605 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198019606 amino acid transporter; Region: 2A0306; TIGR00909 264198019607 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 264198019608 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198019609 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 264198019610 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 264198019611 NAD binding site [chemical binding]; other site 264198019612 Phe binding site; other site 264198019613 Bacterial transcriptional activator domain; Region: BTAD; smart01043 264198019614 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198019615 cyclase homology domain; Region: CHD; cd07302 264198019616 dimer interface [polypeptide binding]; other site 264198019617 nucleotidyl binding site; other site 264198019618 metal binding site [ion binding]; metal-binding site 264198019619 AAA ATPase domain; Region: AAA_16; pfam13191 264198019620 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 264198019621 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 264198019622 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 264198019623 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198019624 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 264198019625 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198019626 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 264198019627 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 264198019628 active site 264198019629 catalytic residues [active] 264198019630 metal binding site [ion binding]; metal-binding site 264198019631 DmpG-like communication domain; Region: DmpG_comm; pfam07836 264198019632 acetaldehyde dehydrogenase; Validated; Region: PRK08300 264198019633 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264198019634 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 264198019635 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198019636 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264198019637 DEAD_2; Region: DEAD_2; pfam06733 264198019638 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 264198019639 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 264198019640 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198019641 tetrameric interface [polypeptide binding]; other site 264198019642 NAD binding site [chemical binding]; other site 264198019643 catalytic residues [active] 264198019644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019646 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198019647 putative effector binding pocket; other site 264198019648 dimerization interface [polypeptide binding]; other site 264198019649 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198019650 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198019651 FMN-binding pocket [chemical binding]; other site 264198019652 flavin binding motif; other site 264198019653 phosphate binding motif [ion binding]; other site 264198019654 beta-alpha-beta structure motif; other site 264198019655 NAD binding pocket [chemical binding]; other site 264198019656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198019657 catalytic loop [active] 264198019658 iron binding site [ion binding]; other site 264198019659 Amino acid permease; Region: AA_permease_2; pfam13520 264198019660 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 264198019661 choline dehydrogenase; Validated; Region: PRK02106 264198019662 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198019663 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 264198019664 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198019665 tetramerization interface [polypeptide binding]; other site 264198019666 NAD(P) binding site [chemical binding]; other site 264198019667 catalytic residues [active] 264198019668 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198019669 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198019670 [2Fe-2S] cluster binding site [ion binding]; other site 264198019671 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 264198019672 putative alpha subunit interface [polypeptide binding]; other site 264198019673 putative active site [active] 264198019674 putative substrate binding site [chemical binding]; other site 264198019675 Fe binding site [ion binding]; other site 264198019676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198019677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198019678 non-specific DNA binding site [nucleotide binding]; other site 264198019679 salt bridge; other site 264198019680 sequence-specific DNA binding site [nucleotide binding]; other site 264198019681 PAS domain S-box; Region: sensory_box; TIGR00229 264198019682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198019683 heme pocket [chemical binding]; other site 264198019684 putative active site [active] 264198019685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198019686 PAS fold; Region: PAS_3; pfam08447 264198019687 putative active site [active] 264198019688 heme pocket [chemical binding]; other site 264198019689 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198019690 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198019691 ligand binding site [chemical binding]; other site 264198019692 flexible hinge region; other site 264198019693 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198019694 non-specific DNA interactions [nucleotide binding]; other site 264198019695 DNA binding site [nucleotide binding] 264198019696 sequence specific DNA binding site [nucleotide binding]; other site 264198019697 putative cAMP binding site [chemical binding]; other site 264198019698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198019699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019700 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 264198019701 putative substrate binding pocket [chemical binding]; other site 264198019702 dimerization interface [polypeptide binding]; other site 264198019703 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198019704 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198019705 dimer interface [polypeptide binding]; other site 264198019706 PYR/PP interface [polypeptide binding]; other site 264198019707 TPP binding site [chemical binding]; other site 264198019708 substrate binding site [chemical binding]; other site 264198019709 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198019710 TPP-binding site [chemical binding]; other site 264198019711 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 264198019712 Predicted membrane protein [Function unknown]; Region: COG2259 264198019713 polyphosphate kinase; Provisional; Region: PRK05443 264198019714 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 264198019715 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 264198019716 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198019717 putative active site [active] 264198019718 catalytic site [active] 264198019719 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 264198019720 putative domain interface [polypeptide binding]; other site 264198019721 putative active site [active] 264198019722 catalytic site [active] 264198019723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198019724 PAS domain; Region: PAS_9; pfam13426 264198019725 putative active site [active] 264198019726 heme pocket [chemical binding]; other site 264198019727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198019728 dimer interface [polypeptide binding]; other site 264198019729 phosphorylation site [posttranslational modification] 264198019730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198019731 ATP binding site [chemical binding]; other site 264198019732 Mg2+ binding site [ion binding]; other site 264198019733 G-X-G motif; other site 264198019734 Response regulator receiver domain; Region: Response_reg; pfam00072 264198019735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198019736 active site 264198019737 phosphorylation site [posttranslational modification] 264198019738 intermolecular recognition site; other site 264198019739 dimerization interface [polypeptide binding]; other site 264198019740 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198019741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198019742 active site 264198019743 phosphorylation site [posttranslational modification] 264198019744 intermolecular recognition site; other site 264198019745 dimerization interface [polypeptide binding]; other site 264198019746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198019747 DNA binding residues [nucleotide binding] 264198019748 dimerization interface [polypeptide binding]; other site 264198019749 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 264198019750 trimer interface [polypeptide binding]; other site 264198019751 YadA-like C-terminal region; Region: YadA; pfam03895 264198019752 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 264198019753 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 264198019754 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198019755 ligand binding site [chemical binding]; other site 264198019756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198019757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198019758 DNA binding site [nucleotide binding] 264198019759 domain linker motif; other site 264198019760 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264198019761 dimerization interface [polypeptide binding]; other site 264198019762 ligand binding site [chemical binding]; other site 264198019763 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 264198019764 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 264198019765 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198019766 trimer interface [polypeptide binding]; other site 264198019767 eyelet of channel; other site 264198019768 Cupin domain; Region: Cupin_2; pfam07883 264198019769 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198019770 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198019771 NAD(P) binding site [chemical binding]; other site 264198019772 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 264198019773 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 264198019774 classical (c) SDRs; Region: SDR_c; cd05233 264198019775 NAD(P) binding site [chemical binding]; other site 264198019776 active site 264198019777 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 264198019778 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198019779 active site 264198019780 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198019781 HlyD family secretion protein; Region: HlyD_3; pfam13437 264198019782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264198019783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264198019784 Walker A/P-loop; other site 264198019785 ATP binding site [chemical binding]; other site 264198019786 Q-loop/lid; other site 264198019787 ABC transporter signature motif; other site 264198019788 Walker B; other site 264198019789 D-loop; other site 264198019790 H-loop/switch region; other site 264198019791 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198019792 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198019793 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264198019794 FtsX-like permease family; Region: FtsX; pfam02687 264198019795 benzoate transport; Region: 2A0115; TIGR00895 264198019796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019797 putative substrate translocation pore; other site 264198019798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198019799 salicylate hydroxylase; Provisional; Region: PRK08163 264198019800 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 264198019801 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264198019802 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264198019803 C-terminal domain interface [polypeptide binding]; other site 264198019804 GSH binding site (G-site) [chemical binding]; other site 264198019805 putative dimer interface [polypeptide binding]; other site 264198019806 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264198019807 dimer interface [polypeptide binding]; other site 264198019808 N-terminal domain interface [polypeptide binding]; other site 264198019809 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264198019810 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198019811 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 264198019812 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 264198019813 Cupin domain; Region: Cupin_2; pfam07883 264198019814 Cupin domain; Region: Cupin_2; cl17218 264198019815 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198019816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264198019817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198019818 dimerization interface [polypeptide binding]; other site 264198019819 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198019820 homotrimer interaction site [polypeptide binding]; other site 264198019821 putative active site [active] 264198019822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198019823 I-site; other site 264198019824 active site 264198019825 metal binding site [ion binding]; metal-binding site 264198019826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198019827 dimerization interface [polypeptide binding]; other site 264198019828 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198019829 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198019830 dimer interface [polypeptide binding]; other site 264198019831 putative CheW interface [polypeptide binding]; other site 264198019832 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 264198019833 hypothetical protein; Reviewed; Region: PRK09588 264198019834 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 264198019835 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198019836 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 264198019837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198019838 catalytic residue [active] 264198019839 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 264198019840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198019841 dimer interface [polypeptide binding]; other site 264198019842 conserved gate region; other site 264198019843 putative PBP binding loops; other site 264198019844 ABC-ATPase subunit interface; other site 264198019845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198019846 dimer interface [polypeptide binding]; other site 264198019847 conserved gate region; other site 264198019848 putative PBP binding loops; other site 264198019849 ABC-ATPase subunit interface; other site 264198019850 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 264198019851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264198019852 Walker A/P-loop; other site 264198019853 ATP binding site [chemical binding]; other site 264198019854 Q-loop/lid; other site 264198019855 ABC transporter signature motif; other site 264198019856 Walker B; other site 264198019857 D-loop; other site 264198019858 H-loop/switch region; other site 264198019859 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264198019860 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264198019861 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264198019862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198019863 DNA-binding site [nucleotide binding]; DNA binding site 264198019864 FCD domain; Region: FCD; pfam07729 264198019865 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 264198019866 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 264198019867 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 264198019868 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 264198019869 NAD(P) binding site [chemical binding]; other site 264198019870 catalytic residues [active] 264198019871 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264198019872 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 264198019873 hexamer interface [polypeptide binding]; other site 264198019874 ligand binding site [chemical binding]; other site 264198019875 putative active site [active] 264198019876 NAD(P) binding site [chemical binding]; other site 264198019877 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 264198019878 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 264198019879 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 264198019880 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 264198019881 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264198019882 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 264198019883 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 264198019884 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021