-- dump date 20140620_020917 -- class Genbank::CDS -- table cds_note -- id note YP_001274370.1 PFAM: plasmid replicase; Primase, C-terminal 1 YP_001274374.1 PFAM: helix-turn-helix domain protein YP_001274375.1 PFAM: Resolvase, N-terminal domain YP_001274376.1 PFAM: Sel1 domain protein repeat-containing protein YP_001274377.1 PFAM: protein of unknown function DUF1200 YP_001274382.1 PFAM: mobilisation protein YP_001278911.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001278912.1 TIGRFAM: chromosomal replication initiator protein DnaA; PFAM: Chromosomal replication initiator, DnaA C-terminal domain; Chromosomal replication initiator, DnaA; SMART: AAA ATPase YP_001278913.1 TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain YP_001278914.1 TIGRFAM: DNA replication and repair protein RecF; PFAM: SMC domain protein YP_001278915.1 TIGRFAM: DNA gyrase, B subunit; PFAM: DNA gyrase, subunit B domain protein; ATP-binding region, ATPase domain protein domain protein; TOPRIM domain protein; DNA topoisomerase, type IIA, subunit B, region 2 domain protein; SMART: DNA topoisomerase II YP_001278916.1 PFAM: protein of unknown function DUF204 YP_001278917.1 PFAM: protein of unknown function DUF890 YP_001278918.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001278919.1 PFAM: Auxin Efflux Carrier YP_001278920.1 PFAM: KAP P-loop domain protein YP_001278922.1 PFAM: GCN5-related N-acetyltransferase YP_001278923.1 PFAM: aminotransferase, class I and II YP_001278924.1 TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT transporter YP_001278925.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001278927.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001278929.1 PFAM: extracellular solute-binding protein, family 5 YP_001278930.1 PFAM: extracellular solute-binding protein, family 5 YP_001278931.1 PFAM: extracellular solute-binding protein, family 5 YP_001278932.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001278933.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001278934.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001278935.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001278939.1 PFAM: 2-nitropropane dioxygenase, NPD YP_001278940.1 PFAM: protein of unknown function DUF511 YP_001278941.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001278945.1 PFAM: protein of unknown function UPF0029 YP_001278946.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001278949.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001278951.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001278952.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001278953.1 PFAM: Transglycosylase-associated protein YP_001278954.1 TIGRFAM: UDP-N-acetylmuramate; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001278955.1 PFAM: Disulphide bond formation protein DsbB YP_001278956.1 TIGRFAM: glutamate--cysteine ligase YP_001278957.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_001278958.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001278959.1 PFAM: heat shock protein DnaJ domain protein; chaperone DnaJ domain protein YP_001278961.1 involved in the import of serine and threonine coupled with the import of sodium YP_001278962.1 PFAM: DNA polymerase III chi subunit, HolC YP_001278963.1 PFAM: peptidase M17, leucyl aminopeptidase domain protein YP_001278964.1 PFAM: permease YjgP/YjgQ family protein YP_001278965.1 PFAM: permease YjgP/YjgQ family protein YP_001278966.1 PFAM: methyltransferase small YP_001278967.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001278970.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001278971.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001278973.1 PFAM: transmembrane pair domain protein YP_001278974.1 catalyzes the conversion of citrate to isocitrate YP_001278975.1 PFAM: protein of unknown function DUF1622 YP_001278976.1 PFAM: Amidohydrolase 3 YP_001278978.1 PFAM: alpha/beta hydrolase fold YP_001278980.1 TIGRFAM: lipoyltransferase and lipoate-protein ligase; PFAM: biotin/lipoate A/B protein ligase YP_001278982.1 PFAM: cytochrome B561 YP_001278983.1 PFAM: protein of unknown function DUF214 YP_001278984.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001278985.1 PFAM: stress protein YP_001278986.1 PFAM: protein of unknown function DUF475 YP_001278987.1 PFAM: stress protein YP_001278988.1 PFAM: protein of unknown function DUF124 YP_001278989.1 PFAM: stress protein YP_001278990.1 PFAM: stress protein YP_001278996.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001278997.1 PFAM: lipolytic enzyme, G-D-S-L family YP_001278998.1 PFAM: GCN5-related N-acetyltransferase YP_001278999.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_001279000.1 PFAM: major facilitator superfamily MFS_1 YP_001279002.1 PFAM: ApbE family lipoprotein YP_001279003.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001279004.1 PFAM: transposase, IS4 family protein YP_001279005.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001279006.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_001279007.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_001279008.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001279009.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001279010.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001279011.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001279012.1 PFAM: MscS Mechanosensitive ion channel; transport-associated YP_001279015.1 PFAM: Alcohol dehydrogenase GroES domain protein YP_001279016.1 PFAM: 2OG-Fe(II) oxygenase YP_001279017.1 PFAM: alpha/beta hydrolase fold YP_001279018.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279020.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001279022.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001279023.1 TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region YP_001279026.1 PFAM: acyl-CoA dehydrogenase domain protein YP_001279027.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279029.1 TIGRFAM: shikimate 5-dehydrogenase; PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein YP_001279034.1 PFAM: Dam-replacing family protein YP_001279035.1 PFAM: aminodeoxychorismate lyase YP_001279036.1 PFAM: thymidylate kinase YP_001279037.1 PFAM: sodium/hydrogen exchanger YP_001279038.1 TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein YP_001279039.1 PFAM: Pirin domain protein domain protein; Pirin domain protein YP_001279040.1 PFAM: protein of unknown function DUF45 YP_001279041.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001279042.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase YP_001279043.1 PFAM: cell division protein FtsL YP_001279044.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001279045.1 TIGRFAM: UDP-N-acetylmuramyl-tripeptide synthetase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001279046.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001279047.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001279048.1 PFAM: Methyltransferase type 11 YP_001279049.1 TIGRFAM: tyrosine recombinase XerD; PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein YP_001279050.1 PFAM: SirA family protein YP_001279051.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279053.1 PFAM: Holliday junction resolvase YqgF; SMART: Resolvase, RNase H domain protein fold YP_001279054.1 PFAM: protein of unknown function DUF179 YP_001279055.1 TIGRFAM: DNA repair protein RecN; PFAM: SMC domain protein YP_001279056.1 PFAM: protein of unknown function DUF1255 YP_001279057.1 TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001279058.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001279059.1 PFAM: peptidase A24A, prepilin type IV; peptidase A24A domain protein YP_001279060.1 PFAM: type II secretion system protein YP_001279061.1 PFAM: type II secretion system protein E YP_001279062.1 PFAM: triosephosphate isomerase YP_001279063.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit YP_001279064.1 PFAM: protein of unknown function DUF150 YP_001279065.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001279066.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001279067.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001279068.1 TIGRFAM: tRNA pseudouridine synthase B; PFAM: pseudouridylate synthase TruB domain protein YP_001279069.1 PFAM: ThiJ/PfpI domain protein YP_001279072.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001279073.1 PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH, type 1, domain protein; SMART: KH domain protein YP_001279074.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001279075.1 PFAM: acyl-CoA thioesterase YP_001279076.1 TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein YP_001279077.1 TIGRFAM: A/G-specific adenine glycosylase; PFAM: HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001279078.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_001279079.1 PFAM: dienelactone hydrolase YP_001279080.1 PFAM: protein of unknown function UPF0153 YP_001279081.1 PFAM: Rh family protein/ammonium transporter YP_001279082.1 PFAM: nitrogen regulatory protein P-II YP_001279083.1 PFAM: UspA domain protein YP_001279084.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS; Xanthine/uracil/vitamin C permease; sulphate transporter YP_001279085.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001279086.1 PFAM: cell cycle protein YP_001279087.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279088.1 PFAM: glutamyl-tRNA synthetase, class Ic YP_001279089.1 TIGRFAM: RNA polymerase-binding protein DksA; PFAM: zinc finger, DksA/TraR C4-type YP_001279090.1 PFAM: metallophosphoesterase; Calcineurin phosphoesterase C-terminal domain protein YP_001279091.1 PFAM: ABC-3 protein YP_001279092.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279094.1 PFAM: periplasmic solute binding protein YP_001279096.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001279097.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001279098.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001279099.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001279100.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001279101.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001279102.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001279103.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001279104.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279105.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001279106.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279107.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001279108.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001279109.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001279110.1 TIGRFAM: 16S rRNA processing protein RimM; PFAM: RimM protein; PRC-barrel domain protein YP_001279111.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001279112.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001279114.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001279115.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279117.1 PFAM: Beta-ketoacyl synthase-like YP_001279120.1 PFAM: BolA family protein YP_001279121.1 PFAM: peptidase M48, Ste24p YP_001279122.1 TIGRFAM: trimethylamine-N-oxide reductase c-type cytochrome TorC; PFAM: NapC/NirT cytochrome c domain protein YP_001279123.1 TIGRFAM: trimethylamine-N-oxide reductase TorA; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001279124.1 PFAM: cytoplasmic chaperone TorD family protein YP_001279125.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV YP_001279126.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001279127.1 TIGRFAM: molybdenum cofactor synthesis domain; molybdenum cofactor biosynthesis protein B; PFAM: molybdopterin binding domain YP_001279129.1 TIGRFAM: molybdenum cofactor biosynthesis protein C; PFAM: molybdopterin cofactor biosynthesis MoaC region YP_001279130.1 TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein YP_001279131.1 PFAM: molybdopterin biosynthesis MoaE protein YP_001279132.1 TIGRFAM: molybdate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001279133.1 TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein YP_001279134.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001279135.1 PFAM: Na+/H+ antiporter NhaC YP_001279136.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; Male sterility C-terminal domain YP_001279138.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; sugar transferase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001279139.1 PFAM: glycosyl transferase, group 1 YP_001279140.1 PFAM: glycosyl transferase, group 1 YP_001279142.1 PFAM: Integrase, catalytic region YP_001279143.1 PFAM: transposase IS3/IS911 family protein YP_001279145.1 PFAM: transposase IS3/IS911 family protein YP_001279146.1 TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase YP_001279147.1 PFAM: glycosyl transferase, group 1 YP_001279148.1 PFAM: polysaccharide biosynthesis protein YP_001279149.1 PFAM: glycosyl transferase, group 1 YP_001279150.1 PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II YP_001279151.1 PFAM: transferase hexapeptide repeat containing protein YP_001279152.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001279153.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; Male sterility C-terminal domain YP_001279154.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase-like YP_001279155.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; Male sterility C-terminal domain YP_001279156.1 PFAM: lipopolysaccharide biosynthesis protein YP_001279157.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001279158.1 PFAM: polysaccharide export protein YP_001279159.1 PFAM: UvrD/REP helicase YP_001279160.1 PFAM: alpha/beta hydrolase fold YP_001279161.1 PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II YP_001279162.1 PFAM: AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001279165.1 TIGRFAM: citrate synthase I; PFAM: Citrate synthase YP_001279166.1 TIGRFAM: Succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase, cytochrome b subunit YP_001279167.1 TIGRFAM: Succinate dehydrogenase, hydrophobic membrane anchor YP_001279168.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001279169.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001279170.1 PFAM: Insertion element protein; IS1 transposase YP_001279171.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001279172.1 TIGRFAM: 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein YP_001279173.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001279174.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001279175.1 TIGRFAM: succinyl-CoA synthetase, alpha subunit; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase YP_001279176.1 PFAM: Nucleotidyl transferase YP_001279177.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001279178.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase, dimerisation YP_001279179.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III YP_001279180.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase-like YP_001279181.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001279182.1 TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; SMART: Helix-hairpin-helix DNA-binding, class 1 YP_001279184.1 PFAM: Na+/solute symporter YP_001279186.1 TIGRFAM: amino acid carrier protein; PFAM: sodium:alanine symporter YP_001279187.1 PFAM: FAD dependent oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase YP_001279188.1 PFAM: protein of unknown function DUF1285 YP_001279189.1 TIGRFAM: glutamate racemase; PFAM: Asp/Glu racemase YP_001279191.1 TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein YP_001279192.1 PFAM: Aldose 1-epimerase YP_001279193.1 PFAM: thiopurine S-methyltransferase YP_001279194.1 TIGRFAM: peptide methionine sulfoxide reductase; PFAM: Methionine sulfoxide reductase A YP_001279195.1 TIGRFAM: putative methyltransferase; PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001279196.1 TIGRFAM: putative methyltransferase; PFAM: methyltransferase, putative YP_001279197.1 PFAM: protein of unknown function DUF1176 YP_001279199.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001279200.1 PFAM: Sporulation domain protein YP_001279201.1 PFAM: regulatory protein, IclR; Transcriptional regulator IclR-like YP_001279202.1 TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding YP_001279203.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001279204.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001279205.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001279206.1 TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase YP_001279207.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_001279208.1 PFAM: major facilitator superfamily MFS_1 YP_001279209.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001279210.1 binds and unfolds substrates as part of the ClpXP protease YP_001279211.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001279212.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001279213.1 TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM: Ham1 family protein YP_001279214.1 PFAM: manganese and iron superoxide dismutase YP_001279215.1 PFAM: protein of unknown function DUF72 YP_001279216.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001279217.1 PFAM: Rhomboid family protein YP_001279218.1 PFAM: OmpA/MotB domain protein YP_001279219.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001279220.1 TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41 YP_001279221.1 PFAM: CsbD family protein YP_001279222.1 PFAM: transposase, IS4 family protein YP_001279223.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001279224.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001279227.1 TIGRFAM: alkylphosphonate utilization operon protein PhnA; PFAM: PhnA protein-like YP_001279228.1 PFAM: DegV family protein YP_001279229.1 PFAM: protein of unknown function DUF344 YP_001279230.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279231.1 TIGRFAM: ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD; PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001279232.1 PFAM: cytochrome bd ubiquinol oxidase, subunit I YP_001279233.1 TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase, subunit II YP_001279234.1 TIGRFAM: cyd operon protein YbgT; PFAM: membrane bound YbgT family protein YP_001279235.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001279236.1 PFAM: Ppx/GppA phosphatase YP_001279237.1 TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; PFAM: acetyl-CoA carboxylase, alpha subunit YP_001279238.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001279239.1 TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001279240.1 PFAM: formate dehydrogenase, subunit FdhD YP_001279241.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein; Protein of unkown function DUF1946, PP-loop ATpase YP_001279242.1 TIGRFAM: pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein YP_001279243.1 PFAM: protein of unknown function YGGT YP_001279244.1 PFAM: RDD domain containing protein YP_001279245.1 PFAM: Hemerythrin HHE cation binding domain protein YP_001279246.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_001279247.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001279248.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein YP_001279249.1 TIGRFAM: nicotinate (nicotinamide) nucleotide adenylyltransferase; PFAM: cytidylyltransferase YP_001279250.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001279251.1 TIGRFAM: acetate kinase; PFAM: acetate and butyrate kinase YP_001279253.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001279254.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001279255.1 PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein YP_001279256.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001279257.1 TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: sigma-54 factor; sigma-54 factor, core-binding region; sigma-54, DNA-binding domain protein YP_001279258.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA YP_001279259.1 TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein YP_001279260.1 PFAM: protein of unknown function DUF423 YP_001279261.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001279262.1 PFAM: SirA family protein YP_001279263.1 PFAM: peptidase M48, Ste24p YP_001279264.1 PFAM: GatB/Yqey domain protein YP_001279265.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001279268.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001279269.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein YP_001279270.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001279271.1 PFAM: sodium:dicarboxylate symporter YP_001279272.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279273.1 PFAM: protein of unknown function DUF81 YP_001279274.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001279277.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001279278.1 TIGRFAM: signal peptidase I; PFAM: peptidase S24, S26A and S26B YP_001279279.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001279280.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001279281.1 TIGRFAM: DNA repair protein RecO; PFAM: Recombination protein O, RecO YP_001279282.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001279284.1 PFAM: OmpA/MotB domain protein YP_001279285.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein YP_001279286.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001279287.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001279288.1 TIGRFAM: RelA/SpoT family protein; PFAM: amino acid-binding ACT domain protein; TGS domain protein; RelA/SpoT domain protein YP_001279289.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001279291.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001279292.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; Hpt domain protein YP_001279293.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001279294.1 TIGRFAM: drug resistance transporter, Bcr/CflA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001279296.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001279298.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001279299.1 PFAM: Rhodanese domain protein YP_001279300.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001279302.1 PFAM: Fimbrial assembly family protein YP_001279304.1 TIGRFAM: type IV pilus secretin PilQ; PFAM: type II and III secretion system protein; NolW domain protein; Secretin/TonB, short N-terminal domain YP_001279305.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001279306.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001279308.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001279309.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001279310.1 PFAM: carbonic anhydrase YP_001279311.1 TIGRFAM: lactoylglutathione lyase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001279312.1 PFAM: MscS Mechanosensitive ion channel YP_001279313.1 PFAM: cytochrome c, class II YP_001279314.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001279315.1 PFAM: GTP cyclohydrolase II YP_001279316.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001279317.1 PFAM: inositol monophosphatase YP_001279319.1 TIGRFAM: formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; amino acid-binding ACT domain protein YP_001279321.1 PFAM: protein of unknown function DUF560; Tetratricopeptide TPR_2 repeat protein YP_001279322.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001279323.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001279324.1 TIGRFAM: glutamyl-tRNA(Gln) amidotransferase, C subunit YP_001279325.1 functions in MreBCD complex in some organisms YP_001279326.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001279328.1 TIGRFAM: maf protein; PFAM: Maf family protein YP_001279329.1 TIGRFAM: ribonuclease, Rne/Rng family YP_001279330.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001279331.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001279332.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001279333.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001279334.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001279335.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001279336.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001279337.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001279338.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001279339.1 one of the stabilizing components for the large ribosomal subunit YP_001279340.1 PFAM: ribosomal protein S17 YP_001279341.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001279342.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001279343.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001279344.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001279345.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001279346.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001279347.1 binds 5S rRNA along with protein L5 and L25 YP_001279348.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001279349.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001279350.1 late assembly protein YP_001279351.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001279352.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001279353.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001279354.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001279355.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001279356.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001279357.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC, N-terminal domain YP_001279358.1 PFAM: protein of unknown function DUF462 YP_001279359.1 PFAM: protein of unknown function DUF177 YP_001279360.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001279361.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase YP_001279362.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001279363.1 TIGRFAM: acyl carrier protein; PFAM: phosphopantetheine-binding YP_001279364.1 PFAM: Peptidoglycan-binding LysM YP_001279365.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; domain of unknown function DUF1730 YP_001279366.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: protein of unknown function UPF0031; YjeF-family N-terminal domain protein YP_001279368.1 PFAM: NUDIX hydrolase YP_001279369.1 PFAM: NUDIX hydrolase YP_001279370.1 PFAM: biotin/lipoate A/B protein ligase YP_001279371.1 PFAM: protein of unknown function DUF81 YP_001279372.1 PFAM: SMC domain protein YP_001279373.1 PFAM: ZipA, C-terminal FtsZ-binding region YP_001279374.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001279375.1 PFAM: Phosphoglycerate mutase YP_001279376.1 PFAM: aminoglycoside phosphotransferase YP_001279377.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001279378.1 TIGRFAM: DNA ligase, NAD-dependent; PFAM: BRCT domain protein; zinc-finger, NAD-dependent DNA ligase C4-type; NAD-dependent DNA ligase, OB-fold; NAD-dependent DNA ligase, adenylation; SMART: Helix-hairpin-helix DNA-binding, class 1; NAD-dependent DNA ligase-like YP_001279379.1 PFAM: FAD dependent oxidoreductase YP_001279380.1 PFAM: Endoribonuclease L-PSP YP_001279382.1 PFAM: von Willebrand factor, type A YP_001279383.1 PFAM: protein of unknown function DUF808 YP_001279384.1 TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein YP_001279385.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001279386.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001279387.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_001279390.1 PFAM: protein of unknown function UPF0047 YP_001279391.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001279392.1 TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein YP_001279393.1 PFAM: cytochrome c, class I YP_001279394.1 PFAM: peptidase M23B YP_001279395.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001279396.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001279397.1 TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein YP_001279398.1 PFAM: nitroreductase YP_001279399.1 PFAM: protein of unknown function DUF81 YP_001279400.1 PFAM: HhH-GPD family protein YP_001279401.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001279402.1 PFAM: protein of unknown function UPF0102 YP_001279403.1 PFAM: transport-associated YP_001279405.1 PFAM: BolA family protein YP_001279406.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001279407.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_001279408.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001279409.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001279410.1 PFAM: Anthranilate synthase component I and chorismate binding protein YP_001279412.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001279413.1 PFAM: secretion protein HlyD family protein YP_001279415.1 TIGRFAM: integral membrane protein MviN; PFAM: polysaccharide biosynthesis protein; virulence factor MVIN family protein YP_001279416.1 PFAM: HpcH/HpaI aldolase YP_001279417.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2 YP_001279419.1 PFAM: Protein of unknown function DUF676, hydrolase domain protein; PGAP1 family protein YP_001279424.1 PFAM: NAD-dependent epimerase/dehydratase YP_001279426.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001279427.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001279429.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001279430.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001279431.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001279432.1 PFAM: cell division protein FtsQ YP_001279433.1 PFAM: cell division protein FtsA YP_001279434.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001279435.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001279438.1 PFAM: protein of unknown function UPF0044 YP_001279439.1 PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ YP_001279440.1 TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; peptidase M41, FtsH extracellular; SMART: AAA ATPase YP_001279441.1 TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS YP_001279442.1 PFAM: protein of unknown function DUF339 YP_001279444.1 PFAM: protein of unknown function DUF937 YP_001279445.1 PFAM: peptidase M22, glycoprotease YP_001279446.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001279448.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001279449.1 PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding YP_001279450.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001279453.1 PFAM: peptidase M48, Ste24p YP_001279454.1 PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2 YP_001279457.1 TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: peptidase S13, D-Ala-D-Ala carboxypeptidase C YP_001279458.1 3'-5' exonuclease of DNA polymerase III YP_001279459.1 PFAM: CBS domain containing protein; protein of unknown function DUF294, nucleotidyltransferase putative YP_001279460.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate YP_001279461.1 TIGRFAM: protein-P-II uridylyltransferase; PFAM: amino acid-binding ACT domain protein; DNA polymerase, beta domain protein region; metal-dependent phosphohydrolase, HD sub domain; GlnD PII-uridylyltransferase; SMART: metal-dependent phosphohydrolase, HD region YP_001279462.1 TIGRFAM: methionine aminopeptidase, type I; PFAM: peptidase M24 YP_001279463.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001279464.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001279466.1 PFAM: phosphoenolpyruvate carboxylase YP_001279467.1 PFAM: Putative mono-oxygenase ydhR YP_001279468.1 PFAM: protein of unknown function DUF6, transmembrane YP_001279469.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease YP_001279470.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001279471.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001279472.1 PFAM: BLUF domain protein YP_001279473.1 PFAM: FAD linked oxidase domain protein YP_001279474.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001279475.1 PFAM: beta-lactamase domain protein YP_001279477.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein YP_001279478.1 TIGRFAM: primosomal protein N'; PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001279479.1 TIGRFAM: putative endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP YP_001279480.1 PFAM: TGS domain protein; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001279481.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001279482.1 Essential for recycling GMP and indirectly, cGMP YP_001279483.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001279485.1 molecular chaperone YP_001279486.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001279487.1 activates fatty acids by binding to coenzyme A YP_001279488.1 TIGRFAM: S-formylglutathione hydrolase; PFAM: putative esterase YP_001279489.1 PFAM: ribulose-phosphate 3-epimerase; Orotidine 5'-phosphate decarboxylase; thiamine monophosphate synthase YP_001279493.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001279494.1 required for 70S ribosome assembly YP_001279495.1 PFAM: major facilitator superfamily MFS_1 YP_001279496.1 PFAM: cytochrome c assembly protein YP_001279497.1 TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54, G- domain; Signal peptide binding (SRP54) M- domain protein; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001279498.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001279500.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001279501.1 PFAM: beta-Ig-H3/fasciclin YP_001279502.1 TIGRFAM: amino acid carrier protein; PFAM: sodium:alanine symporter YP_001279503.1 PFAM: LemA family protein YP_001279504.1 PFAM: protein of unknown function DUF477 YP_001279505.1 PFAM: protein of unknown function DUF477 YP_001279506.1 PFAM: Silent information regulator protein Sir2 YP_001279508.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279510.1 PFAM: cytochrome c, class I YP_001279511.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279512.1 PFAM: ABC-2 type transporter YP_001279513.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001279514.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_001279515.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001279516.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001279518.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001279519.1 PFAM: Electron transfer flavoprotein, alpha/beta-subunit-like YP_001279520.1 PFAM: Electron transfer flavoprotein, alpha/beta-subunit-like; Electron transfer flavoprotein, alpha subunit-like YP_001279521.1 PFAM: GCN5-related N-acetyltransferase YP_001279522.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_001279523.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001279524.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001279525.1 PFAM: cell divisionFtsK/SpoIIIE YP_001279526.1 PFAM: Pirin domain protein domain protein YP_001279527.1 PFAM: Amidase YP_001279528.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001279529.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001279531.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279532.1 TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase YP_001279533.1 PFAM: GCN5-related N-acetyltransferase YP_001279534.1 PFAM: sodium/hydrogen exchanger YP_001279535.1 TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN YP_001279536.1 PFAM: flavodoxin/nitric oxide synthase YP_001279539.1 PFAM: NAD(P) transhydrogenase, beta subunit YP_001279541.1 PFAM: alanine dehydrogenase/PNT domain protein YP_001279542.1 PFAM: protein of unknown function DUF328 YP_001279543.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001279544.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001279546.1 PFAM: protein of unknown function DUF528 YP_001279547.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001279548.1 PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit YP_001279549.1 PFAM: protein of unknown function DUF519 YP_001279550.1 TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001279551.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001279552.1 PFAM: OsmC family protein YP_001279554.1 PFAM: protein of unknown function DUF938 YP_001279555.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001279556.1 PFAM: ABC-2 type transporter YP_001279558.1 PFAM: secretion protein HlyD family protein YP_001279559.1 PFAM: outer membrane efflux protein YP_001279561.1 PFAM: Catalase domain protein YP_001279562.1 PFAM: small multidrug resistance protein YP_001279563.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279564.1 PFAM: transport system permease protein YP_001279565.1 PFAM: transport system permease protein YP_001279566.1 PFAM: periplasmic binding protein YP_001279567.1 PFAM: major facilitator superfamily MFS_1 YP_001279568.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001279569.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase, dimerisation and phosphoacceptor region YP_001279570.1 TIGRFAM: nitrite transporter; PFAM: major facilitator superfamily MFS_1 YP_001279571.1 TIGRFAM: nitrate reductase, beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001279572.1 TIGRFAM: nitrate reductase molybdenum cofactor assembly chaperone; PFAM: Nitrate reductase, delta subunit YP_001279573.1 TIGRFAM: respiratory nitrate reductase, gamma subunit; PFAM: Nitrate reductase, gamma subunit YP_001279574.1 PFAM: globin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001279575.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001279577.1 PFAM: Protein of unknown function DUF1971 YP_001279578.1 TIGRFAM: arsenate reductase; PFAM: arsenate reductase and related YP_001279579.1 PFAM: FeoA family protein YP_001279580.1 TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Ferrous iron transport protein B domain protein; Ferrous iron transport B domain protein; nucleoside recognition domain protein YP_001279581.1 PFAM: fumarylacetoacetate (FAA) hydrolase YP_001279582.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain YP_001279583.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279584.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001279585.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001279586.1 PFAM: extracellular solute-binding protein, family 3 YP_001279587.1 TIGRFAM: diaminopimelate dehydrogenase YP_001279590.1 PFAM: phage integrase family protein YP_001279594.1 PFAM: Oxidoreductase FAD-binding domain protein; FAD-binding 8 domain protein; Ferric reductase domain protein transmembrane component, N-terminal domain YP_001279595.1 PFAM: cytochrome B561 YP_001279596.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001279597.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001279600.1 PFAM: ApbE family lipoprotein YP_001279602.1 PFAM: protein of unknown function DUF125, transmembrane YP_001279603.1 PFAM: cation efflux protein YP_001279604.1 PFAM: Insertion element protein; IS1 transposase YP_001279606.1 PFAM: transposase, IS4 family protein YP_001279607.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001279608.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001279609.1 TIGRFAM: heavy metal response regulator; PFAM: response regulator receiver; transcriptional regulator domain protein YP_001279613.1 PFAM: protein of unknown function DUF411 YP_001279614.1 TIGRFAM: copper-resistance protein, CopA family; PFAM: multicopper oxidase, type 1; multicopper oxidase, type 2; multicopper oxidase, type 3 YP_001279615.1 PFAM: copper resistance B precursor YP_001279616.1 PFAM: protein of unknown function DUF305 YP_001279617.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein YP_001279618.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001279619.1 TIGRFAM: twin-arginine translocation protein, TatB subunit; PFAM: sec-independent translocation protein mttA/Hcf106 YP_001279620.1 TIGRFAM: Sec-independent protein translocase, TatC subunit; PFAM: Sec-independent periplasmic protein translocase YP_001279623.1 PFAM: Resolvase, N-terminal domain; Resolvase helix-turn-helix domain protein YP_001279624.1 PFAM: helix-turn-helix- domain containing protein, AraC type; ThiJ/PfpI domain protein YP_001279625.1 PFAM: isochorismatase hydrolase YP_001279627.1 PFAM: filamentation induced by cAMP protein Fic YP_001279629.1 PFAM: phage integrase family protein YP_001279633.1 PFAM: transposase IS3/IS911 family protein YP_001279634.1 PFAM: Integrase, catalytic region YP_001279635.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein YP_001279637.1 TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase, N-terminal domain YP_001279638.1 PFAM: regulatory protein, IclR YP_001279639.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001279640.1 PFAM: Cupin 2, conserved barrel domain protein YP_001279641.1 TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase, N-terminal domain YP_001279642.1 PFAM: fumarylacetoacetate (FAA) hydrolase YP_001279643.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001279644.1 PFAM: aldehyde dehydrogenase YP_001279645.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein YP_001279646.1 PFAM: transport system permease protein; ABC-3 protein YP_001279647.1 PFAM: periplasmic binding protein YP_001279648.1 PFAM: SMC domain protein; ABC transporter related; SMART: AAA ATPase YP_001279649.1 PFAM: protein of unknown function DUF6, transmembrane YP_001279651.1 TIGRFAM: potassium uptake protein, TrkH family; PFAM: cation transporter YP_001279652.1 PFAM: TrkA-N domain protein YP_001279653.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001279655.1 PFAM: DNA photolyase, FAD-binding; DNA photolyase domain protein YP_001279656.1 PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) YP_001279657.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001279658.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001279659.1 TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit YP_001279660.1 TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein YP_001279661.1 PFAM: outer membrane efflux protein YP_001279662.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001279663.1 TIGRFAM: type I secretion membrane fusion protein, HlyD family; PFAM: secretion protein HlyD family protein YP_001279664.1 PFAM: aldehyde dehydrogenase YP_001279665.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001279667.1 PFAM: NnrS family protein YP_001279668.1 PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein YP_001279669.1 PFAM: ABC-1 domain protein YP_001279670.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001279671.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001279672.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001279674.1 TIGRFAM: cytochrome oxidase maturation protein, cbb3-type; PFAM: cytochrome oxidase maturation protein cbb3-type YP_001279675.1 PFAM: protein of unknown function DUF218 YP_001279676.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001279677.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001279678.1 PFAM: RNA-binding S4 domain protein YP_001279679.1 TIGRFAM: TonB family protein YP_001279680.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001279681.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001279682.1 PFAM: alpha/beta hydrolase fold YP_001279683.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001279684.1 TIGRFAM: alanine racemase; PFAM: alanine racemase domain protein YP_001279685.1 PFAM: ABC-1 domain protein YP_001279687.1 TIGRFAM: ubiquinone/menaquinone biosynthesis methyltransferase; PFAM: UbiE/COQ5 methyltransferase; Methyltransferase type 11; Methyltransferase type 12 YP_001279689.1 PFAM: protein of unknown function DUF344 YP_001279690.1 PFAM: phosphate transporter YP_001279692.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001279693.1 PFAM: protein of unknown function UPF0126 YP_001279694.1 PFAM: Stringent starvation protein B YP_001279695.1 PFAM: Glutathione S-transferase, N-terminal domain YP_001279696.1 PFAM: cytochrome c1 YP_001279697.1 PFAM: Cytochrome b/b6, N-terminal domain; Cytochrome b/b6, C-terminal domain YP_001279698.1 TIGRFAM: ubiquinol-cytochrome c reductase, iron-sulfur subunit; PFAM: Rieske [2Fe-2S] domain protein YP_001279699.1 forms a direct contact with the tRNA during translation YP_001279700.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001279701.1 TIGRFAM: putative methyltransferase; PFAM: conserved hypothetical protein 95 YP_001279702.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001279704.1 TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein YP_001279705.1 TIGRFAM: periplasmic protein thiol--disulphide oxidoreductase DsbE; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001279706.1 PFAM: cytochrome C biogenesis protein YP_001279708.1 PFAM: adenylate kinase; adenylate kinase, lid domain protein YP_001279709.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001279710.1 TIGRFAM: glutaredoxin 3; PFAM: glutaredoxin YP_001279711.1 PFAM: Rhodanese domain protein YP_001279712.1 TIGRFAM: ribosome small subunit-dependent GTPase A; PFAM: GTPase EngC YP_001279713.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001279714.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001279715.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type YP_001279716.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001279717.1 in Corynebacterium glutamicum the aminotransferase can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; this protein contains a helix-turn-helix domain at the N-terminus YP_001279718.1 TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B YP_001279720.1 PFAM: protein of unknown function UPF0079 YP_001279721.1 PFAM: ATP-binding region, ATPase domain protein domain protein; DNA mismatch repair protein, C-terminal domain protein YP_001279722.1 TIGRFAM: tRNA delta(2)-isopentenylpyrophosphate transferase; PFAM: tRNA isopentenyltransferase YP_001279723.1 TIGRFAM: RNA chaperone Hfq; PFAM: Like-Sm ribonucleoprotein, core YP_001279724.1 TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS) YP_001279725.1 TIGRFAM: hydrolase, HAD-superfamily, subfamily IIIA; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family YP_001279726.1 PFAM: protein of unknown function DUF1239 YP_001279727.1 TIGRFAM: Cell envelope biogenesis YhbN; PFAM: OstA family protein YP_001279728.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279729.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001279730.1 TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1 YP_001279731.1 TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase YP_001279732.1 PFAM: hydroxyethylthiazole kinase YP_001279733.1 TIGRFAM: rare lipoprotein A; PFAM: Rare lipoprotein A YP_001279734.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001279735.1 TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein YP_001279736.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001279737.1 PFAM: phosphoesterase, PA-phosphatase related YP_001279739.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; PFAM: HAD-superfamily hydrolase, subfamily IB hypothetical 1 YP_001279740.1 TIGRFAM: peptide chain release factor 2; PFAM: Class I peptide chain release factor; PCRF domain protein YP_001279741.1 PFAM: DoxX family protein YP_001279742.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001279745.1 PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase YP_001279746.1 TIGRFAM: cobalamin 5'-phosphate synthase; PFAM: cobalamin-5-phosphate synthase CobS YP_001279747.1 PFAM: Phosphoglycerate mutase YP_001279748.1 PFAM: HPP family protein+B94 YP_001279749.1 PFAM: multiple antibiotic resistance (MarC)-related protein YP_001279750.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001279751.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_001279752.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001279753.1 PFAM: nucleoside recognition domain protein YP_001279754.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001279755.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein YP_001279756.1 PFAM: regulatory protein, ArsR YP_001279757.1 PFAM: protein of unknown function DUF395, YeeE/YedE YP_001279758.1 PFAM: protein of unknown function DUF395, YeeE/YedE YP_001279759.1 PFAM: GCN5-related N-acetyltransferase YP_001279760.1 PFAM: protein of unknown function UPF0027 YP_001279762.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279763.1 PFAM: protein of unknown function DUF1255 YP_001279764.1 PFAM: AMP-dependent synthetase and ligase YP_001279765.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001279767.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001279768.1 PFAM: Three-deoxy-D-manno-octulosonic-acid transferase domain protein YP_001279769.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001279771.1 PFAM: extracellular solute-binding protein, family 1 YP_001279772.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001279773.1 PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001279774.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001279775.1 TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal repeat, beta-propeller YP_001279776.1 PFAM: Glutathione S-transferase, N-terminal domain YP_001279778.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001279779.1 TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT transporter YP_001279781.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001279782.1 TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein YP_001279783.1 TIGRFAM: electron transport complex, RnfABCDGE type, B subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Fe-S cluster domain protein YP_001279787.1 TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein YP_001279788.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein YP_001279789.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein YP_001279790.1 PFAM: Polyprenyl synthetase YP_001279791.1 PFAM: ribosomal protein L21 YP_001279792.1 involved in the peptidyltransferase reaction during translation YP_001279793.1 PFAM: outer membrane lipoprotein carrier protein LolA YP_001279794.1 PFAM: regulatory protein, TetR YP_001279796.1 PFAM: Radical SAM domain protein YP_001279797.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001279799.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001279800.1 PFAM: Carboxymuconolactone decarboxylase YP_001279801.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001279802.1 PFAM: aminotransferase, class I and II YP_001279803.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001279804.1 PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001279805.1 TIGRFAM: replicative DNA helicase; PFAM: DnaB domain protein helicase, N-terminal domain protein; DnaB domain protein helicase, C-terminal domain protein YP_001279806.1 TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA YP_001279807.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001279808.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001279809.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001279811.1 PFAM: acyl-CoA dehydrogenase domain protein YP_001279812.1 PFAM: acyl-CoA dehydrogenase domain protein YP_001279813.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001279814.1 TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase YP_001279815.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001279817.1 PFAM: 4'-phosphopantetheinyl transferase YP_001279818.1 TIGRFAM: Peptidoglycan-associated lipoprotein; PFAM: OmpA/MotB domain protein YP_001279820.1 TIGRFAM: aminopeptidase N; PFAM: Peptidase M1, membrane alanine aminopeptidase-like YP_001279821.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001279822.1 TIGRFAM: lipid-A-disaccharide synthase; PFAM: glycosyl transferase, family 19 YP_001279823.1 PFAM: ribonuclease HII/HIII YP_001279827.1 PFAM: Peptidoglycan-binding domain 1 protein; ErfK/YbiS/YcfS/YnhG family protein YP_001279828.1 involved in methylation of ribosomal protein L3 YP_001279829.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001279830.1 PFAM: nitroreductase YP_001279831.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001279832.1 PFAM: Phosphoglycerate mutase YP_001279834.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001279835.1 PFAM: Colicin V production protein YP_001279836.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001279837.1 PFAM: Endoribonuclease L-PSP YP_001279838.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter YP_001279839.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001279840.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001279841.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001279842.1 TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein YP_001279844.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001279845.1 PFAM: metallophosphoesterase YP_001279846.1 PFAM: Phosphoglycerate mutase YP_001279847.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001279848.1 PFAM: RDD domain containing protein YP_001279849.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001279850.1 PFAM: protein of unknown function DUF299 YP_001279851.1 catalyzes the conversion of NADPH to NADH YP_001279852.1 PFAM: histidine triad (HIT) protein YP_001279853.1 TIGRFAM: putative TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase, DuS; dihydroorotate dehydrogenase YP_001279854.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001279855.1 PFAM: GTP cyclohydrolase I YP_001279858.1 PFAM: Cupin 4 family protein; SMART: transcription factor jumonji, jmjC domain protein YP_001279860.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001279861.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001279862.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001279863.1 TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin YP_001279865.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_001279866.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001279867.1 PFAM: phospholipase/Carboxylesterase YP_001279868.1 PFAM: alpha/beta hydrolase fold YP_001279869.1 acts as a molecular chaperone to fold and export lipase A YP_001279871.1 PFAM: Inorganic pyrophosphatase YP_001279872.1 PFAM: Entericidin EcnAB YP_001279873.1 PFAM: tRNA/rRNA methyltransferase (SpoU) YP_001279874.1 PFAM: DsrC family protein YP_001279877.1 PFAM: DsrE family protein YP_001279878.1 PFAM: glycosyl transferase, group 1 YP_001279879.1 PFAM: phosphoesterase, PA-phosphatase related YP_001279880.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001279881.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001279882.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001279884.1 PFAM: Capsular polysaccharide synthesis YP_001279886.1 PFAM: glycosyl transferase, family 25 YP_001279887.1 PFAM: glycosyl transferase, family 25 YP_001279890.1 PFAM: lipid A biosynthesis acyltransferase YP_001279891.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001279892.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001279893.1 PFAM: alpha/beta hydrolase fold YP_001279895.1 TIGRFAM: ATP-dependent helicase HrpA; PFAM: helicase domain protein; helicase-associated domain protein; protein of unknown function DUF1605; SMART: AAA ATPase; DEAD-like helicases-like YP_001279897.1 PFAM: Siderophore-interacting protein; FAD-binding 9, siderophore-interacting domain protein YP_001279898.1 PFAM: alpha/beta hydrolase fold YP_001279899.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001279900.1 PFAM: alpha/beta hydrolase fold YP_001279901.1 TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54, G- domain; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001279902.1 TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding YP_001279903.1 PFAM: helix-turn-helix- domain containing protein, AraC type; ThiJ/PfpI domain protein YP_001279904.1 PFAM: acyl-CoA dehydrogenase domain protein YP_001279905.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001279906.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR YP_001279907.1 PFAM: ferredoxin; [2Fe-2S]-binding domain protein YP_001279908.1 PFAM: molybdopterin dehydrogenase, FAD-binding YP_001279909.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding YP_001279910.1 PFAM: protein of unknown function DUF182 YP_001279912.1 PFAM: cytochrome P450 YP_001279913.1 PFAM: protein of unknown function DUF28 YP_001279914.1 PFAM: Ion transport protein; Ion transport 2 domain protein YP_001279915.1 PFAM: ABC-1 domain protein YP_001279916.1 PFAM: protein of unknown function DUF1275 YP_001279917.1 PFAM: Lysine exporter protein (LYSE/YGGA) YP_001279918.1 PFAM: regulatory protein, AsnC/Lrp family YP_001279919.1 TIGRFAM: 2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain YP_001279920.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001279921.1 PFAM: protein of unknown function DUF218 YP_001279922.1 PFAM: peptidase U32 YP_001279924.1 PFAM: Integrase, catalytic region YP_001279925.1 PFAM: transposase IS3/IS911 family protein YP_001279927.1 PFAM: transposase IS3/IS911 family protein YP_001279928.1 PFAM: Integrase, catalytic region YP_001279929.1 PFAM: Hemolysin-type calcium-binding region; Cadherin YP_001279930.1 PFAM: conserved hypothetical protein 698 YP_001279931.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001279932.1 TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase; PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001279933.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001279934.1 PFAM: MscS Mechanosensitive ion channel YP_001279935.1 TIGRFAM: aminoacyl-histidine dipeptidase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001279937.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001279938.1 TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase; Domain of unknown function DUF1969 YP_001279939.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001279940.1 TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001279941.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_001279942.1 PFAM: transcriptional coactivator/pterin dehydratase YP_001279943.1 PFAM: Na+/H+ antiporter NhaC YP_001279944.1 PFAM: phosphoesterase, PA-phosphatase related YP_001279945.1 PFAM: diacylglycerol kinase YP_001279946.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001279947.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001279948.1 PFAM: sulfatase; protein of unknown function DUF1705 YP_001279952.1 PFAM: transposase IS3/IS911 family protein YP_001279953.1 PFAM: Integrase, catalytic region YP_001279955.1 PFAM: Integrase, catalytic region YP_001279957.1 PFAM: transposase IS3/IS911 family protein YP_001279958.1 PFAM: IS66 Orf2 family protein YP_001279959.1 PFAM: transposase IS66 YP_001279961.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001279962.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001279963.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001279964.1 PFAM: extracellular solute-binding protein, family 1 YP_001279966.1 PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_001279969.1 PFAM: protein of unknown function UPF0187 YP_001279970.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279971.1 PFAM: iron-containing alcohol dehydrogenase YP_001279975.1 PFAM: phosphoesterase, PA-phosphatase related YP_001279978.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001279979.1 PFAM: regulatory protein, LysR YP_001279980.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001279981.1 PFAM: AMP-dependent synthetase and ligase YP_001279982.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001279984.1 PFAM: FAD linked oxidase domain protein; D-arabinono-1,4-lactone oxidase YP_001279985.1 PFAM: KWG Leptospira repeat protein YP_001279986.1 PFAM: OmpA/MotB domain protein YP_001279987.1 TIGRFAM: putative outer membrane adhesin like proteiin; PFAM: Hemolysin-type calcium-binding region; Na-Ca exchanger/integrin-beta4 YP_001279988.1 PFAM: transposase IS66 YP_001279989.1 PFAM: IS66 Orf2 family protein YP_001279990.1 PFAM: transposase IS3/IS911 family protein YP_001279991.1 PFAM: Integrase, catalytic region YP_001279993.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain YP_001279994.1 PFAM: ThiJ/PfpI domain protein YP_001279995.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein YP_001279996.1 PFAM: iron-containing alcohol dehydrogenase YP_001279997.1 PFAM: regulatory protein, TetR YP_001279998.1 PFAM: NAD-glutamate dehydrogenase YP_001279999.1 PFAM: SMC domain protein YP_001280000.1 TIGRFAM: nuclease SbcCD, D subunit; PFAM: metallophosphoesterase YP_001280001.1 PFAM: methyltransferase small YP_001280002.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280003.1 PFAM: periplasmic binding protein YP_001280004.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001280005.1 PFAM: major facilitator superfamily MFS_1 YP_001280006.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280007.1 TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001280008.1 PFAM: phosphoadenosine phosphosulfate reductase YP_001280010.1 PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region YP_001280011.1 ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms YP_001280013.1 PFAM: phospholipase D/Transphosphatidylase YP_001280014.1 PFAM: protein of unknown function DUF45 YP_001280015.1 TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; PFAM: type III restriction enzyme, res subunit; protein of unknown function DUF450; SMART: DEAD-like helicases-like YP_001280017.1 PFAM: transposase IS3/IS911 family protein YP_001280019.1 PFAM: transposase IS3/IS911 family protein YP_001280020.1 PFAM: Integrase, catalytic region YP_001280024.1 PFAM: phage integrase family protein YP_001280025.1 PFAM: phage integrase family protein YP_001280026.1 PFAM: N-6 DNA methylase YP_001280031.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001280032.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001280033.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysT; PFAM: binding-protein-dependent transport systems inner membrane component YP_001280034.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysW; PFAM: binding-protein-dependent transport systems inner membrane component YP_001280035.1 TIGRFAM: sulfate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001280036.1 PFAM: UspA domain protein YP_001280037.1 PFAM: regulatory protein, ArsR YP_001280038.1 TIGRFAM: arsenical pump membrane protein; PFAM: Arsenical pump membrane protein; Citrate transporter YP_001280039.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001280040.1 TIGRFAM: Arsenate resistance ArsH; PFAM: NADPH-dependent FMN reductase YP_001280041.1 PFAM: MgtC/SapB transporter YP_001280043.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001280044.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001280045.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_001280046.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001280047.1 PFAM: DSBA oxidoreductase YP_001280048.1 TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain YP_001280049.1 PFAM: extracellular solute-binding protein, family 3 YP_001280050.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001280051.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280052.1 TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I YP_001280053.1 PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein YP_001280054.1 PFAM: Trp repressor YP_001280056.1 PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein YP_001280057.1 PFAM: protein of unknown function DUF819 YP_001280058.1 PFAM: protein of unknown function DUF980 YP_001280059.1 TIGRFAM: dethiobiotin synthase YP_001280060.1 TIGRFAM: phenazine biosynthesis protein PhzF family; PFAM: Phenazine biosynthesis PhzC/PhzF protein YP_001280062.1 TIGRFAM: dethiobiotin synthase YP_001280063.1 TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III YP_001280064.1 PFAM: Integrase, catalytic region YP_001280065.1 PFAM: transposase IS3/IS911 family protein YP_001280066.1 TIGRFAM: putative outer membrane adhesin like proteiin; PFAM: Hemolysin-type calcium-binding region; Haemolysin-type calcium binding domain protein YP_001280067.1 PFAM: alpha/beta hydrolase fold YP_001280069.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase YP_001280070.1 PFAM: helix-turn-helix, HxlR type YP_001280071.1 TIGRFAM: putative polyhydroxyalkanoic acid system protein YP_001280072.1 PFAM: regulatory protein, TetR YP_001280073.1 PFAM: beta-Ig-H3/fasciclin YP_001280074.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR YP_001280075.1 PFAM: amine oxidase YP_001280076.1 PFAM: Cyclopropane-fatty-acyl-phospholipid synthase; Methyltransferase type 11; Methyltransferase type 12 YP_001280078.1 PFAM: NAD(P)H dehydrogenase (quinone) YP_001280079.1 PFAM: aldo/keto reductase YP_001280080.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280082.1 PFAM: AMP-dependent synthetase and ligase YP_001280083.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F YP_001280084.1 PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding YP_001280085.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001280086.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001280087.1 PFAM: regulatory protein, TetR YP_001280088.1 PFAM: phage integrase family protein YP_001280090.1 PFAM: protein of unknown function DUF779 YP_001280091.1 PFAM: aldehyde dehydrogenase YP_001280095.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280096.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_001280097.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_001280098.1 Catalyzes the conversion of citrate to isocitrate YP_001280099.1 TIGRFAM: putative AcnD-accessory protein PrpF; PFAM: protein of unknown function DUF453 YP_001280100.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001280101.1 PFAM: GCN5-related N-acetyltransferase YP_001280104.1 PFAM: GTP-binding protein, HSR1-related YP_001280105.1 TIGRFAM: arsenite-activated ATPase ArsA; PFAM: Anion-transporting ATPase; SMART: AAA ATPase YP_001280107.1 PFAM: carbon starvation protein CstA YP_001280109.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively YP_001280110.1 TIGRFAM: exodeoxyribonuclease V, alpha subunit YP_001280111.1 PFAM: UvrD/REP helicase YP_001280113.1 PFAM: pseudouridine synthase YP_001280114.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001280115.1 PFAM: phage integrase family protein YP_001280117.1 TIGRFAM: Dyp-type peroxidase family YP_001280119.1 PFAM: protein of unknown function DUF6, transmembrane YP_001280127.1 PFAM: transposase IS3/IS911 family protein YP_001280128.1 PFAM: Integrase, catalytic region YP_001280129.1 PFAM: peptidase M14, carboxypeptidase A YP_001280130.1 TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP C-terminal domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: phosphoesterase PHP domain protein YP_001280131.1 PFAM: isochorismatase hydrolase YP_001280132.1 PFAM: protein of unknown function DUF1427 YP_001280135.1 PFAM: BCCT transporter YP_001280136.1 PFAM: peptidase M19, renal dipeptidase YP_001280137.1 PFAM: aldehyde dehydrogenase YP_001280138.1 PFAM: Endoribonuclease L-PSP YP_001280139.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280140.1 TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU) YP_001280141.1 TIGRFAM: serine O-acetyltransferase YP_001280143.1 TIGRFAM: dihydroneopterin aldolase YP_001280144.1 TIGRFAM: RarD protein, DMT superfamily transporter; PFAM: protein of unknown function DUF6, transmembrane YP_001280145.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate and catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001280146.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001280147.1 TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; amino acid-binding ACT domain protein YP_001280148.1 PFAM: Transaldolase YP_001280149.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001280150.1 PFAM: Rubredoxin-type Fe(Cys)4 protein YP_001280151.1 PFAM: alpha/beta hydrolase fold YP_001280152.1 PFAM: alpha/beta hydrolase fold YP_001280154.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001280155.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001280156.1 TIGRFAM: pyridoxamine 5'-phosphate oxidase; PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding YP_001280157.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001280158.1 TIGRFAM: inosine-5'-monophosphate dehydrogenase; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase YP_001280159.1 PFAM: MscS Mechanosensitive ion channel YP_001280160.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001280161.1 TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase YP_001280163.1 PFAM: glycerophosphoryl diester phosphodiesterase YP_001280164.1 PFAM: fatty acid desaturase YP_001280165.1 PFAM: protein of unknown function UPF0061 YP_001280166.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001280167.1 PFAM: BLUF domain protein YP_001280168.1 PFAM: Polynucleotide adenylyltransferase region YP_001280169.1 PFAM: phage integrase family protein YP_001280171.1 PFAM: protein of unknown function DUF6, transmembrane YP_001280194.1 TIGRFAM: putative lipoprotein; PFAM: protein of unknown function DUF285, lipoprotein YP_001280209.1 PFAM: transposase IS3/IS911 family protein YP_001280210.1 PFAM: Integrase, catalytic region YP_001280217.1 PFAM: LrgB family protein YP_001280218.1 PFAM: LrgA family protein YP_001280219.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280220.1 PFAM: type III restriction enzyme, res subunit; protein of unknown function DUF450; SMART: DEAD-like helicases-like YP_001280222.1 PFAM: restriction modification system DNA specificity domain YP_001280223.1 PFAM: N-6 DNA methylase YP_001280226.1 PFAM: VRR-NUC YP_001280234.1 PFAM: helix-turn-helix domain protein; peptidase S24, S26A and S26B; bacteriophage CI repressor YP_001280237.1 PFAM: Uncharacterized protein UPF0114 YP_001280238.1 PFAM: Citrate transporter; Na+/H+ antiporter NhaC YP_001280248.1 McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity YP_001280250.1 PFAM: transposase IS3/IS911 family protein YP_001280251.1 PFAM: Integrase, catalytic region YP_001280252.1 PFAM: transposase IS3/IS911 family protein YP_001280253.1 PFAM: Integrase, catalytic region YP_001280254.1 PFAM: ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001280257.1 PFAM: Integrase, catalytic region YP_001280259.1 PFAM: transposase IS3/IS911 family protein YP_001280260.1 PFAM: IS66 Orf2 family protein YP_001280261.1 PFAM: transposase IS66 YP_001280262.1 TIGRFAM: putative outer membrane adhesin like proteiin; PFAM: glycosyl hydrolase, BNR repeat-containing protein; Na-Ca exchanger/integrin-beta4 YP_001280263.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001280264.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001280266.1 PFAM: Gluconate transporter; Citrate transporter YP_001280267.1 PFAM: glycerate kinase YP_001280268.1 TIGRFAM: gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase YP_001280269.1 TIGRFAM: peptide methionine sulfoxide reductase; methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase A; Methionine sulfoxide reductase B; Redoxin domain protein YP_001280270.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280271.1 PFAM: binding-protein-dependent transport systems inner membrane component; Substrate-binding region of ABC-type glycine betaine transport system YP_001280272.1 PFAM: Class I peptide chain release factor YP_001280273.1 PFAM: aldehyde dehydrogenase YP_001280274.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001280275.1 TIGRFAM: lipoate-protein ligase B; PFAM: biotin/lipoate A/B protein ligase YP_001280277.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001280280.1 PFAM: sodium/hydrogen exchanger YP_001280281.1 PFAM: beta-lactamase YP_001280283.1 PFAM: MaoC domain protein dehydratase YP_001280284.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001280285.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001280287.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001280288.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001280289.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001280290.1 TIGRFAM: lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001280291.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease YP_001280292.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001280293.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001280294.1 PFAM: peptidase S16, lon domain protein YP_001280297.1 PFAM: Ion transport protein; Ion transport 2 domain protein YP_001280298.1 TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein YP_001280299.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001280301.1 PFAM: AFG1-family ATPase YP_001280304.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001280305.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001280306.1 PFAM: beta-lactamase domain protein YP_001280307.1 PFAM: extracellular solute-binding protein, family 5 YP_001280308.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001280310.1 PFAM: NLPA lipoprotein YP_001280311.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001280312.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280314.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001280315.1 PFAM: ABC-1 domain protein YP_001280316.1 PFAM: putative methyltransferase YP_001280317.1 PFAM: protein of unknown function DUF329 YP_001280318.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_001280319.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001280321.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001280323.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 YP_001280324.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001280325.1 TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41 YP_001280326.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001280327.1 PFAM: FxsA cytoplasmic membrane protein YP_001280328.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001280330.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain YP_001280331.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001280334.1 PFAM: protein of unknown function UPF0118 YP_001280335.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001280336.1 TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein YP_001280337.1 PFAM: Lysine exporter protein (LYSE/YGGA) YP_001280338.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280339.1 PFAM: NMT1/THI5 like YP_001280340.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001280341.1 PFAM: aldehyde dehydrogenase YP_001280342.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280343.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_001280344.1 PFAM: CHAD domain containing protein; adenylate cyclase YP_001280345.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001280347.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001280348.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280349.1 TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001280351.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001280352.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001280353.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001280355.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001280356.1 PFAM: sodium:dicarboxylate symporter YP_001280357.1 PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase YP_001280358.1 PFAM: porin, Gram-negative type YP_001280361.1 PFAM: regulatory protein, TetR YP_001280362.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001280363.1 PFAM: transposase IS3/IS911 family protein YP_001280365.1 PFAM: Integrase, catalytic region YP_001280366.1 PFAM: Integrase, catalytic region YP_001280367.1 PFAM: transposase IS3/IS911 family protein YP_001280370.1 PFAM: Integrase, catalytic region YP_001280371.1 PFAM: transposase IS3/IS911 family protein YP_001280372.1 PFAM: Integrase, catalytic region YP_001280374.1 PFAM: transposase IS3/IS911 family protein YP_001280375.1 PFAM: IS66 Orf2 family protein YP_001280376.1 PFAM: transposase IS66 YP_001280379.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001280380.1 PFAM: KWG Leptospira repeat protein YP_001280382.1 PFAM: isochorismatase hydrolase YP_001280383.1 PFAM: Secreted repeat of unknown function YP_001280384.1 PFAM: nucleoside recognition domain protein YP_001280385.1 PFAM: Integrase, catalytic region YP_001280386.1 PFAM: transposase IS3/IS911 family protein YP_001280388.1 PFAM: Integrase, catalytic region YP_001280389.1 PFAM: transposase IS3/IS911 family protein YP_001280390.1 PFAM: homocysteine S-methyltransferase YP_001280391.1 PFAM: Spore germination protein; amino acid permease-associated region YP_001280392.1 PFAM: major facilitator superfamily MFS_1 YP_001280393.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280394.1 TIGRFAM: cyclic peptide transporter; PFAM: ABC transporter related; SMART: AAA ATPase YP_001280395.1 PFAM: Siderophore-interacting protein YP_001280396.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280397.1 PFAM: Integrase, catalytic region YP_001280398.1 PFAM: transposase IS3/IS911 family protein YP_001280399.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280400.1 PFAM: Haemin-degrading family protein YP_001280401.1 PFAM: periplasmic binding protein YP_001280402.1 PFAM: transport system permease protein YP_001280403.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280405.1 PFAM: Biopolymer transport protein ExbD/TolR YP_001280406.1 PFAM: MotA/TolQ/ExbB proton channel YP_001280407.1 TIGRFAM: TonB family protein YP_001280408.1 PFAM: YceI family protein YP_001280409.1 PFAM: protein of unknown function DUF924 YP_001280410.1 PFAM: protein of unknown function DUF305 YP_001280412.1 TIGRFAM: TonB-dependent heme/hemoglobin receptor family protein; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280414.1 PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit YP_001280415.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280416.1 PFAM: Insertion element protein; IS1 transposase YP_001280417.1 PFAM: extracellular solute-binding protein, family 5 YP_001280418.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001280419.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001280420.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001280421.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001280422.1 PFAM: amino acid permease-associated region YP_001280423.1 TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III YP_001280424.1 TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase YP_001280425.1 PFAM: regulatory protein, IclR; Transcriptional regulator IclR-like YP_001280426.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F YP_001280427.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001280428.1 PFAM: regulatory protein, IclR; Transcriptional regulator IclR-like YP_001280429.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001280430.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001280432.1 PFAM: Ferritin, Dps family protein YP_001280433.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter YP_001280434.1 PFAM: AzlC family protein YP_001280435.1 PFAM: branched-chain amino acid transport YP_001280436.1 catalyzes the formation of fumarate from aspartate YP_001280438.1 TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001280439.1 PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; BFD domain protein [2Fe-2S]-binding domain protein YP_001280440.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001280441.1 PFAM: protein kinase; SMART: protein phosphatase 2C domain protein; serine/threonine protein kinase YP_001280442.1 PFAM: major facilitator superfamily MFS_1 YP_001280443.1 TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein YP_001280444.1 TIGRFAM: nitrite reductase [NAD(P)H], small subunit YP_001280445.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001280448.1 PFAM: thioesterase superfamily protein YP_001280450.1 PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001280451.1 SMART: AAA ATPase YP_001280453.1 PFAM: beta-lactamase domain protein YP_001280455.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_001280456.1 PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter YP_001280457.1 TIGRFAM: Tol-Pal system, TolQ; PFAM: MotA/TolQ/ExbB proton channel YP_001280458.1 PFAM: Biopolymer transport protein ExbD/TolR YP_001280459.1 TIGRFAM: TonB family protein YP_001280460.1 PFAM: WD40 domain protein beta Propeller YP_001280461.1 PFAM: NADPH-dependent FMN reductase; flavodoxin/nitric oxide synthase YP_001280462.1 PFAM: protein of unknown function DUF152 YP_001280463.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001280465.1 TIGRFAM: DNA primase; PFAM: zinc finger, CHC2-family protein; TOPRIM domain protein; DNA primase catalytic core, N-terminal domain; SMART: Toprim sub domain protein YP_001280466.1 TIGRFAM: RNA polymerase sigma factor RpoD; RNA polymerase sigma-70; PFAM: sigma-70 1.1 domain protein; sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; sigma-70, non-essential domain protein; sigma-70 region 1.2 YP_001280467.1 PFAM: protein of unknown function DUF493 YP_001280468.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001280469.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001280470.1 PFAM: ferredoxin YP_001280471.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein YP_001280472.1 PFAM: protein of unknown function DUF34 YP_001280473.1 PFAM: Lytic transglycosylase, catalytic YP_001280474.1 PFAM: Peptidoglycan-binding LysM; Lytic transglycosylase, catalytic; MLTD_N domain protein YP_001280476.1 PFAM: CBS domain containing protein; protein of unknown function DUF21 YP_001280477.1 PFAM: histone family protein DNA-binding protein YP_001280478.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001280479.1 TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region YP_001280480.1 PFAM: CMP/dCMP deaminase, zinc-binding YP_001280481.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001280482.1 TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001280484.1 PFAM: Auxin Efflux Carrier YP_001280485.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein YP_001280486.1 TIGRFAM: Pyruvate oxidase; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein YP_001280487.1 PFAM: ATP-dependent Clp protease adaptor protein ClpS YP_001280489.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001280490.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001280491.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001280492.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001280493.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_001280494.1 PFAM: Lipocalin family protein YP_001280495.1 PFAM: NUDIX hydrolase; thiamine monophosphate synthase YP_001280497.1 PFAM: protein of unknown function DUF490 YP_001280498.1 PFAM: surface antigen (D15) YP_001280499.1 PFAM: major facilitator superfamily MFS_1 YP_001280501.1 PFAM: conserved hypothetical protein 341 YP_001280502.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001280503.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001280504.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001280505.1 PFAM: HopJ type III effector protein YP_001280506.1 PFAM: transposase, IS4 family protein YP_001280507.1 PFAM: protein of unknown function DUF1315 YP_001280508.1 catalyzes the phosphorylation of NAD to NADP YP_001280509.1 PFAM: protein of unknown function DUF1112 YP_001280510.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001280511.1 TIGRFAM: penicillin-binding protein 1B; penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001280513.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001280514.1 PFAM: helix-turn-helix, Fis-type YP_001280515.1 involved in de novo purine biosynthesis YP_001280516.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001280517.1 PFAM: histone family protein DNA-binding protein YP_001280519.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001280520.1 TIGRFAM: cysteine desulfurase IscS; PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001280521.1 TIGRFAM: FeS cluster assembly scaffold IscU; PFAM: nitrogen-fixing NifU domain protein YP_001280522.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; iron-sulfur cluster assembly protein IscA; PFAM: HesB/YadR/YfhF-family protein YP_001280523.1 TIGRFAM: co-chaperone Hsc20; PFAM: heat shock protein DnaJ domain protein; HSCB oligomerisation domain protein YP_001280524.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001280525.1 TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin YP_001280526.1 PFAM: histidine triad (HIT) protein YP_001280527.1 TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001280528.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001280530.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001280531.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001280532.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001280533.1 TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain YP_001280534.1 PFAM: protein of unknown function DUF541 YP_001280535.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_001280536.1 TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I YP_001280537.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001280538.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001280539.1 PFAM: Smr protein/MutS2 YP_001280540.1 PFAM: MscS Mechanosensitive ion channel YP_001280541.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001280542.1 PFAM: regulatory protein, TetR YP_001280543.1 PFAM: Endonuclease/exonuclease/phosphatase YP_001280544.1 TIGRFAM: glycerol kinase; PFAM: carbohydrate kinase, FGGY YP_001280545.1 TIGRFAM: putative oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001280546.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001280547.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein; PFAM: biotin/lipoyl attachment domain-containing protein YP_001280548.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein YP_001280549.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001280550.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001280551.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001280552.1 TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase YP_001280553.1 PFAM: Septum formation initiator YP_001280554.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001280555.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001280556.1 TIGRFAM: copper ion binding protein; PFAM: Heavy metal transport/detoxification protein YP_001280558.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001280559.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001280560.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001280561.1 PFAM: porin, Gram-negative type YP_001280562.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_001280563.1 PFAM: tRNA--hydroxylase YP_001280565.1 PFAM: transposase, IS4 family protein YP_001280568.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001280569.1 TIGRFAM: monofunctional biosynthetic peptidoglycan transglycosylase; PFAM: glycosyl transferase, family 51 YP_001280570.1 PFAM: glutaredoxin 2 YP_001280571.1 TIGRFAM: L-lactate transport; PFAM: L-lactate permease YP_001280572.1 PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase YP_001280573.1 PFAM: Rhomboid family protein YP_001280574.1 PFAM: MltA-interacting MipA family protein YP_001280576.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001280577.1 TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain N; PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001280578.1 Catalyzes the transfer of electrons from NADH to quinone YP_001280579.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001280580.1 PFAM: NADH-ubiquinone oxidoreductase, chain 4L YP_001280581.1 PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 YP_001280582.1 Catalyzes the transfer of electrons from NADH to quinone YP_001280583.1 Catalyzes the transfer of electrons from NADH to quinone YP_001280584.1 Catalyzes the transfer of electrons from NADH to quinone YP_001280585.1 TIGRFAM: NADH-quinone oxidoreductase, F subunit; PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001280586.1 Catalyzes the transfer of electrons from NADH to quinone YP_001280587.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001280588.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001280589.1 PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 YP_001280590.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001280593.1 TIGRFAM: magnesium transporter; PFAM: CBS domain containing protein; MgtE integral membrane region; MgtE intracellular region YP_001280594.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate YP_001280595.1 TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase YP_001280596.1 TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase YP_001280597.1 PFAM: Gluconate transporter; Citrate transporter YP_001280598.1 PFAM: short chain fatty acid transporter YP_001280599.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001280600.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001280601.1 PFAM: protein of unknown function DUF534 YP_001280602.1 PFAM: protein of unknown function DUF534 YP_001280603.1 PFAM: inner-membrane translocator YP_001280604.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280605.1 PFAM: Saccharopine dehydrogenase YP_001280606.1 TIGRFAM: carboxynorspermidine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001280609.1 PFAM: AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001280611.1 PFAM: protein of unknown function DUF709 YP_001280612.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001280613.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001280614.1 PFAM: nitroreductase YP_001280615.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001280616.1 PFAM: Protein of unknown function DUF676, hydrolase domain protein YP_001280617.1 PFAM: HRDC domain protein; 3'-5' exonuclease YP_001280618.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001280619.1 PFAM: conserved hypothetical protein 103 YP_001280620.1 TIGRFAM: O-succinylhomoserine sulfhydrylase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001280621.1 PFAM: NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein YP_001280622.1 PFAM: phospholipase D/Transphosphatidylase YP_001280623.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001280624.1 TIGRFAM: TIM-barrel protein, yjbN family; PFAM: dihydrouridine synthase, DuS YP_001280625.1 PFAM: Abortive infection protein YP_001280627.1 TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: peptidase S14, ClpP; peptidase S49 YP_001280628.1 PFAM: ComEC/Rec2-related protein YP_001280629.1 TIGRFAM: lipoprotein releasing system, ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase YP_001280630.1 TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; PFAM: protein of unknown function DUF214 YP_001280634.1 CcoN; FixN YP_001280635.1 CcoO; FixO YP_001280636.1 PFAM: Cbb3-type cytochrome oxidase component YP_001280637.1 PFAM: cytochrome c, class I YP_001280638.1 TIGRFAM: Cytochrome c oxidase cbb3 type, accessory protein FixG; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001280640.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001280642.1 PFAM: Nucleotidyl transferase YP_001280643.1 PFAM: aminoglycoside phosphotransferase YP_001280644.1 PFAM: Organic solvent tolerance protein YP_001280645.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; SurA N-terminal domain YP_001280646.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B YP_001280648.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein YP_001280649.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001280651.1 TIGRFAM: potassium efflux system protein; PFAM: TrkA-N domain protein; sodium/hydrogen exchanger YP_001280653.1 TIGRFAM: tRNA (guanine-N(7)-)-methyltransferase; PFAM: putative methyltransferase YP_001280654.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001280655.1 PFAM: Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B YP_001280656.1 TIGRFAM: exsB protein; PFAM: ExsB family protein YP_001280658.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001280659.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001280660.1 PFAM: MscS Mechanosensitive ion channel YP_001280661.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001280662.1 TIGRFAM: modification methylase, HemK family; PFAM: methyltransferase small YP_001280663.1 PFAM: major facilitator superfamily MFS_1 YP_001280664.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280665.1 PFAM: Pyrrolo-quinoline quinone YP_001280666.1 PFAM: luciferase family protein YP_001280667.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001280670.1 PFAM: Auxin Efflux Carrier YP_001280671.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001280672.1 PFAM: peptidase M16 domain protein YP_001280673.1 PFAM: peptidase M16 domain protein YP_001280676.1 TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein YP_001280677.1 PFAM: Radical SAM domain protein YP_001280679.1 PFAM: glycosyl transferase, group 1 YP_001280680.1 PFAM: Endonuclease/exonuclease/phosphatase YP_001280681.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001280682.1 PFAM: sodium:neurotransmitter symporter YP_001280683.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001280684.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001280685.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001280686.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein YP_001280687.1 TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50 YP_001280688.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001280689.1 PFAM: phosphatidate cytidylyltransferase YP_001280690.1 TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Di-trans-poly-cis-decaprenylcistransferase YP_001280691.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001280692.1 Catalyzes the phosphorylation of UMP to UDP YP_001280693.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001280694.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001280695.1 TIGRFAM: nitrogen regulation protein NR(I); PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase YP_001280696.1 PFAM: protein kinase; SMART: serine/threonine protein kinase YP_001280697.1 PFAM: protein of unknown function DUF815 YP_001280699.1 PFAM: MaoC domain protein dehydratase YP_001280700.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001280701.1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_001280703.1 TIGRFAM: magnesium and cobalt transport protein CorA; PFAM: Mg2+ transporter protein, CorA family protein YP_001280704.1 PFAM: phosphate-starvation-inducible E YP_001280705.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001280706.1 PFAM: Fimbrial protein-like YP_001280707.1 PFAM: fimbrial biogenesis outer membrane usher protein YP_001280708.1 PFAM: pili assembly chaperone YP_001280709.1 PFAM: Fimbrial protein-like YP_001280711.1 PFAM: peptidase U61, LD-carboxypeptidase A YP_001280712.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001280713.1 PFAM: OmpW family protein YP_001280714.1 PFAM: UvrD/REP helicase YP_001280715.1 TIGRFAM: magnesium transporter; PFAM: CBS domain containing protein; MgtE integral membrane region; MgtE intracellular region YP_001280716.1 catalyzes the formation of dUMP from dUTP YP_001280717.1 PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III YP_001280718.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001280719.1 PFAM: arsenate reductase and related YP_001280720.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001280722.1 TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta YP_001280723.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein YP_001280724.1 PFAM: ABC transporter related; protein of unknown function DUF214; SMART: AAA ATPase YP_001280725.1 PFAM: beta-lactamase domain protein YP_001280726.1 PFAM: Catalase domain protein YP_001280728.1 PFAM: Peptidoglycan-binding LysM; Sporulation domain protein YP_001280729.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001280730.1 TIGRFAM: Acyltransferase, WS/DGAT/MGAT; PFAM: protein of unknown function UPF0089 YP_001280731.1 TIGRFAM: Acyltransferase, WS/DGAT/MGAT; PFAM: protein of unknown function UPF0089 YP_001280733.1 PFAM: peptidase M16 domain protein; Peptidase M16C associated domain protein YP_001280734.1 PFAM: Phosphoglycerate mutase YP_001280735.1 PFAM: PfkB domain protein YP_001280736.1 TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001280737.1 PFAM: HesB/YadR/YfhF-family protein; nitrogen-fixing NifU domain protein YP_001280738.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region YP_001280739.1 TIGRFAM: RarD protein, DMT superfamily transporter YP_001280740.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain YP_001280741.1 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways YP_001280742.1 PFAM: Nicotinate phosphoribosyltransferase and related YP_001280743.1 PFAM: lipolytic enzyme, G-D-S-L family YP_001280746.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001280747.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001280748.1 PFAM: tRNA/rRNA methyltransferase (SpoU) YP_001280749.1 PFAM: 2OG-Fe(II) oxygenase; SMART: Prolyl 4-hydroxylase, alpha subunit YP_001280750.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001280751.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001280752.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001280753.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001280754.1 PFAM: peptidylprolyl isomerase, FKBP-type YP_001280755.1 PFAM: aldo/keto reductase YP_001280756.1 PFAM: phospholipid/glycerol acyltransferase YP_001280757.1 PFAM: phospholipid/glycerol acyltransferase YP_001280758.1 PFAM: GTP-binding protein, HSR1-related YP_001280760.1 PFAM: LrgB family protein YP_001280761.1 PFAM: Lytic transglycosylase, catalytic YP_001280763.1 catalyzes the oxidation of malate to oxaloacetate YP_001280764.1 PFAM: Lytic transglycosylase, catalytic YP_001280765.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001280766.1 PFAM: Lysine exporter protein (LYSE/YGGA) YP_001280767.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_001280770.1 PFAM: protein of unknown function DUF710 YP_001280772.1 TIGRFAM: NAD+ synthetase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; NAD+ synthase; ExsB family protein YP_001280773.1 PFAM: alanine racemase domain protein YP_001280774.1 TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E; SMART: AAA ATPase YP_001280775.1 PFAM: ferric-uptake regulator YP_001280776.1 PFAM: SmpA/OmlA domain protein YP_001280777.1 PFAM: protein of unknown function UPF0125 YP_001280779.1 PFAM: cytochrome c, class I YP_001280781.1 PFAM: GTP-binding protein, HSR1-related YP_001280782.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001280783.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001280784.1 PFAM: protein of unknown function DUF1294 YP_001280785.1 PFAM: FAD dependent oxidoreductase YP_001280786.1 PFAM: conserved hypothetical protein 730 YP_001280788.1 PFAM: Domain of unknown function DUF1853 YP_001280789.1 SMART: Pyrrolo-quinoline quinone YP_001280791.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001280792.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001280794.1 TIGRFAM: type IV pilus biogenesis/stability protein PilW; PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001280795.1 TIGRFAM: radical SAM enzyme, Cfr family; PFAM: Radical SAM domain protein YP_001280796.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001280797.1 PFAM: ferredoxin-dependent glutamate synthase YP_001280799.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001280801.1 dGTPase family type 3 subfamily, presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001280803.1 PFAM: regulatory protein, TetR YP_001280804.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease YP_001280805.1 PFAM: protein of unknown function UPF0066 YP_001280806.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001280808.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001280809.1 TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT transporter YP_001280810.1 PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001280811.1 PFAM: NUDIX hydrolase YP_001280812.1 PFAM: Propeptide, PepSY amd peptidase M4 YP_001280813.1 PFAM: UMUC domain protein DNA-repair protein YP_001280814.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001280817.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001280820.1 PFAM: Asparaginase/glutaminase YP_001280821.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001280822.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001280823.1 PFAM: Peptidoglycan-binding domain 1 protein; ErfK/YbiS/YcfS/YnhG family protein YP_001280824.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001280825.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001280826.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001280827.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001280828.1 PFAM: Insertion element protein; IS1 transposase YP_001280829.1 TIGRFAM: SSS sodium solute transporter superfamily; sodium/proline symporter; PFAM: Na+/solute symporter YP_001280833.1 PFAM: transposase IS3/IS911 family protein YP_001280834.1 PFAM: Integrase, catalytic region YP_001280838.1 PFAM: membrane protein involved in aromatic hydrocarbon degradation YP_001280840.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280841.1 PFAM: lipid A biosynthesis acyltransferase YP_001280842.1 PFAM: Hemolysin-type calcium-binding region YP_001280843.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001280844.1 PFAM: chromosome segregation and condensation protein ScpA YP_001280845.1 TIGRFAM: segregation and condensation protein B; PFAM: chromosome segregation and condensation protein ScpB YP_001280846.1 PFAM: alpha/beta hydrolase fold YP_001280847.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001280850.1 PFAM: Lysine exporter protein (LYSE/YGGA) YP_001280851.1 PFAM: multiple antibiotic resistance (MarC)-related protein YP_001280852.1 TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase YP_001280854.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001280855.1 TIGRFAM: L-aspartate oxidase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase YP_001280856.1 PFAM: protein of unknown function DUF340, membrane YP_001280857.1 PFAM: OmpA/MotB domain protein YP_001280858.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase YP_001280859.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding YP_001280860.1 PFAM: PhoH family protein YP_001280861.1 PFAM: protein of unknown function UPF0054 YP_001280862.1 TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein YP_001280865.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001280866.1 PFAM: 5-formyltetrahydrofolate cyclo-ligase YP_001280868.1 PFAM: Citrate transporter; Na+/H+ antiporter NhaC; TRAP C4-dicarboxylate transport system permease DctM subunit YP_001280869.1 TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16, lon domain protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001280870.1 PFAM: superoxide dismutase, copper/zinc binding YP_001280871.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001280873.1 PFAM: GCN5-related N-acetyltransferase YP_001280874.1 PFAM: tRNA pseudouridine synthase D, TruD YP_001280875.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001280876.1 TIGRFAM: intracellular septation protein A; PFAM: Intracellular septation protein A YP_001280877.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001280879.1 PFAM: FAD dependent oxidoreductase; protein of unknown function DUF752 YP_001280880.1 PFAM: UBA/THIF-type NAD/FAD binding protein YP_001280881.1 PFAM: TatD-related deoxyribonuclease YP_001280882.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n YP_001280883.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001280885.1 TIGRFAM: excinuclease ABC, A subunit; PFAM: ABC transporter related YP_001280887.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001280888.1 PFAM: protein of unknown function DUF503 YP_001280889.1 PFAM: Alpha/beta hydrolase fold-3 domain protein YP_001280890.1 PFAM: nitroreductase YP_001280891.1 PFAM: protein of unknown function DUF368 YP_001280892.1 PFAM: protein of unknown function DUF1212 YP_001280894.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001280895.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001280896.1 TIGRFAM: pantetheine-phosphate adenylyltransferase; cytidyltransferase-related domain; PFAM: cytidylyltransferase YP_001280897.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001280898.1 PFAM: Radical SAM domain protein; Radical SAM N-terminal domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001280900.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001280901.1 TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase YP_001280902.1 PFAM: PRC-barrel domain protein YP_001280904.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001280906.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001280907.1 This protein performs the mismatch recognition step during the DNA repair process YP_001280908.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001280916.1 PFAM: phospholipase A1 YP_001280918.1 PFAM: cytochrome c biogenesis protein, transmembrane region; Thioredoxin domain YP_001280925.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001280926.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001280927.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001280928.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001280929.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001280930.1 binds directly to 23S ribosomal RNA YP_001280931.1 TIGRFAM: transcription termination/antitermination factor NusG; PFAM: transcription antitermination protein NusG; KOW domain protein; SMART: NGN domain protein; KOW (Kyrpides, Ouzounis, Woese) domain protein YP_001280932.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001280933.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001280934.1 PFAM: Forkhead-associated protein YP_001280936.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001280937.1 PFAM: OsmC family protein YP_001280938.1 TIGRFAM: DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease; 3'-5' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2 YP_001280940.1 PFAM: transposase, mutator type YP_001280943.1 PFAM: fatty acid desaturase YP_001280945.1 PFAM: Ferritin, Dps family protein YP_001280947.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001280948.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_001280949.1 TIGRFAM: methionine biosynthesis protein MetW; PFAM: Methionine biosynthesis MetW protein; Methyltransferase type 11 YP_001280950.1 PFAM: Sel1 domain protein repeat-containing protein YP_001280951.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rubredoxin-type Fe(Cys)4 protein; HI0933 family protein YP_001280952.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001280953.1 PFAM: pyruvate carboxyltransferase YP_001280954.1 PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein YP_001280955.1 PFAM: glutathione-dependent formaldehyde-activating, GFA YP_001280956.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001280957.1 PFAM: carboxyl transferase YP_001280958.1 activates fatty acids by binding to coenzyme A YP_001280959.1 PFAM: Hsp33 protein YP_001280960.1 PFAM: Protein of unknown function DUF676, hydrolase domain protein; PGAP1 family protein YP_001280962.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001280963.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001280964.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001280965.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001280966.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001280967.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001280969.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001280970.1 PFAM: sodium/glutamate symporter YP_001280971.1 TIGRFAM: oligoendopeptidase F; PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; Oligopeptidase F YP_001280973.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001280974.1 PFAM: Chorismate lyase YP_001280975.1 PFAM: protein of unknown function DUF482 YP_001280976.1 TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type YP_001280977.1 TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type YP_001280978.1 PFAM: Ion transport 2 domain protein YP_001280979.1 PFAM: pseudouridine synthase YP_001280980.1 PFAM: PDZ/DHR/GLGF domain protein; peptidase M61 domain protein YP_001280981.1 PFAM: peptidylprolyl isomerase, FKBP-type YP_001280982.1 TIGRFAM: Phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001280983.1 TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein YP_001280984.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001280985.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001280986.1 SMART: metal-dependent phosphohydrolase, HD region YP_001280987.1 PFAM: isochorismatase hydrolase YP_001280989.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001280990.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001280991.1 PFAM: Polyprenyl synthetase YP_001280992.1 PFAM: Tetratricopeptide TPR_4 YP_001280993.1 PFAM: outer membrane lipoprotein LolB YP_001280994.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001280995.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001280996.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001280997.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001280998.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001280999.1 TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region YP_001281000.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD dependent oxidoreductase YP_001281001.1 PFAM: AMP-dependent synthetase and ligase YP_001281003.1 TIGRFAM: bacterioferritin; PFAM: Ferritin, Dps family protein YP_001281004.1 TIGRFAM: bacterioferritin; PFAM: Ferritin, Dps family protein YP_001281005.1 PFAM: BFD domain protein [2Fe-2S]-binding domain protein YP_001281006.1 PFAM: DSBA oxidoreductase YP_001281007.1 Involved in ubiquinone biosynthesis YP_001281008.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001281009.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001281010.1 PFAM: zinc finger, DksA/TraR C4-type YP_001281011.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001281012.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase, RNase H domain protein fold YP_001281013.1 PFAM: Saccharopine dehydrogenase YP_001281014.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001281016.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001281019.1 PFAM: uncharacterised P-loop ATPase protein UPF0042 YP_001281020.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001281021.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001281022.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK YP_001281023.1 TIGRFAM: poly(A) polymerase; PFAM: Polynucleotide adenylyltransferase region YP_001281024.1 PFAM: Rhomboid family protein YP_001281025.1 PFAM: 5-nucleotidase YP_001281026.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001281027.1 TIGRFAM: translation initiation factor IF-3; PFAM: initiation factor 3 YP_001281028.1 PFAM: toxic anion resistance family protein YP_001281029.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001281030.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001281031.1 PFAM: protein of unknown function DUF45 YP_001281032.1 PFAM: uncharacterised conserved protein UCP028101 YP_001281034.1 PFAM: protein of unknown function DUF1111 YP_001281036.1 PFAM: OmpA/MotB domain protein YP_001281037.1 PFAM: phospholipid/glycerol acyltransferase YP_001281039.1 TIGRFAM: septum site-determining protein MinC; PFAM: Septum formation inhibitor MinC YP_001281040.1 TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid a,c-diamide synthase YP_001281041.1 TIGRFAM: cell division topological specificity factor MinE; PFAM: Septum formation topological specificity factor MinE YP_001281042.1 PFAM: cytochrome B561 YP_001281045.1 PFAM: response regulator receiver; CheW domain protein; ATP-binding region, ATPase domain protein domain protein; Hpt domain protein YP_001281046.1 PFAM: chemotaxis sensory transducer YP_001281047.1 PFAM: CheW domain protein YP_001281048.1 PFAM: response regulator receiver YP_001281049.1 PFAM: response regulator receiver YP_001281050.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001281051.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001281052.1 PFAM: histone deacetylase superfamily YP_001281054.1 TIGRFAM: heme exporter protein CcmA; PFAM: ABC transporter related; SMART: AAA ATPase YP_001281055.1 PFAM: cytochrome c-type biogenesis protein CcmB YP_001281056.1 TIGRFAM: heme exporter protein CcmC; PFAM: cytochrome c assembly protein YP_001281057.1 PFAM: Heme exporter protein D (CcmD) YP_001281058.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001281060.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001281061.1 PFAM: UspA domain protein YP_001281062.1 PFAM: protein of unknown function DUF454 YP_001281063.1 PFAM: ornithine cyclodeaminase/mu-crystallin YP_001281064.1 PFAM: branched-chain amino acid transport system II carrier protein YP_001281066.1 PFAM: major facilitator superfamily MFS_1 YP_001281068.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001281069.1 PFAM: protein of unknown function DUF74 YP_001281070.1 PFAM: protein of unknown function DUF74 YP_001281074.1 TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001281077.1 TIGRFAM: biotin synthase; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; SMART: Elongator protein 3/MiaB/NifB YP_001281078.1 PFAM: conserved hypothetical protein 701 YP_001281081.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001281082.1 PFAM: AMP-dependent synthetase and ligase YP_001281083.1 PFAM: AMP-dependent synthetase and ligase YP_001281084.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001281085.1 PFAM: protein of unknown function DUF1311 YP_001281086.1 PFAM: Peptidoglycan-binding domain 1 protein; ErfK/YbiS/YcfS/YnhG family protein YP_001281087.1 PFAM: Hemerythrin HHE cation binding domain protein YP_001281088.1 PFAM: AbgT putative transporter YP_001281092.1 PFAM: protein of unknown function DUF1328 YP_001281093.1 PFAM: metallophosphoesterase YP_001281094.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001281095.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, ATPase subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp YP_001281096.1 PFAM: protein of unknown function DUF188 YP_001281097.1 PFAM: tRNA synthetase, class II (D, K and N) YP_001281098.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001281099.1 PFAM: protein of unknown function UPF0118 YP_001281100.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001281101.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001281102.1 PFAM: PspC domain protein YP_001281103.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001281104.1 TIGRFAM: nicotinamide mononucleotide transporter PnuC YP_001281105.1 PFAM: peptidase M48, Ste24p; HtpX domain protein YP_001281106.1 PFAM: protein of unknown function DUF962 YP_001281107.1 PFAM: YceI family protein YP_001281108.1 PFAM: low temperature requirement A YP_001281109.1 PFAM: protein of unknown function DUF1653 YP_001281110.1 PFAM: GCN5-related N-acetyltransferase YP_001281111.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001281112.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein; PFAM: biotin/lipoyl attachment domain-containing protein YP_001281113.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein YP_001281114.1 PFAM: Allophanate hydrolase subunit 1 YP_001281115.1 TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2 YP_001281116.1 PFAM: LamB/YcsF family protein YP_001281117.1 PFAM: branched-chain amino acid transport system II carrier protein YP_001281118.1 PFAM: biotin/lipoyl attachment domain-containing protein YP_001281119.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001281120.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001281121.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain YP_001281122.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS; Xanthine/uracil/vitamin C permease; sulphate transporter YP_001281123.1 PFAM: protein of unknown function DUF442 YP_001281124.1 PFAM: protein of unknown function DUF442 YP_001281125.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein YP_001281126.1 PFAM: protein of unknown function DUF465 YP_001281127.1 TIGRFAM: VacB and RNase II family 3'-5' exoribonuclease; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein; Ribonuclease B, OB region N-terminal domain; SMART: Cold shock protein YP_001281128.1 PFAM: Endonuclease/exonuclease/phosphatase YP_001281130.1 PFAM: peptidase M3A and M3B, thimet/oligopeptidase F YP_001281132.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001281134.1 PFAM: transcriptional coactivator/pterin dehydratase YP_001281137.1 PFAM: CBS domain containing protein; transporter-associated region YP_001281138.1 PFAM: Patatin YP_001281140.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001281141.1 PFAM: FKBP-type peptidyl-prolyl isomerase domain protein; peptidylprolyl isomerase, FKBP-type YP_001281142.1 PFAM: Conserved TM helix repeat-containing protein YP_001281144.1 PFAM: phospholipid/glycerol acyltransferase YP_001281145.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001281146.1 PFAM: protein of unknown function UPF0227 YP_001281147.1 PFAM: protein of unknown function DUF1289 YP_001281149.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001281151.1 PFAM: thioesterase superfamily protein YP_001281153.1 TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase YP_001281154.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001281155.1 PFAM: Fe(II) trafficking protein YggX YP_001281156.1 TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein YP_001281157.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001281158.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component YP_001281159.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstC; PFAM: binding-protein-dependent transport systems inner membrane component YP_001281160.1 TIGRFAM: phosphate ABC transporter, periplasmic phosphate-binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001281161.1 TIGRFAM: rare lipoprotein A; PFAM: Rare lipoprotein A YP_001281162.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001281163.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis YP_001281164.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001281166.1 PFAM: Domain of unknown function DUF1852 YP_001281167.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_001281168.1 PFAM: flavin reductase domain protein, FMN-binding YP_001281169.1 PFAM: protein of unknown function DUF81 YP_001281170.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001281171.1 TIGRFAM: UDP-N-acetylglucosamine pyrophosphorylase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; transferase hexapeptide repeat containing protein; Nucleotidyl transferase YP_001281172.1 PFAM: phosphatidylglycerophosphatase A YP_001281173.1 TIGRFAM: thiamine-monophosphate kinase; PFAM: AIR synthase related protein domain protein YP_001281174.1 TIGRFAM: transcription antitermination factor NusB; PFAM: NusB/RsmB/TIM44 YP_001281175.1 PFAM: 6,7-dimethyl-8-ribityllumazine synthase YP_001281176.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001281177.1 PFAM: Na+/Pi-cotransporter YP_001281178.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_001281180.1 PFAM: glutamine amidotransferase, class-II YP_001281181.1 PFAM: SEC-C motif domain protein YP_001281182.1 PFAM: Neutral/alkaline nonlysosomal ceramidase YP_001281185.1 PFAM: DNA/RNA non-specific endonuclease YP_001281186.1 PFAM: iron-containing alcohol dehydrogenase YP_001281187.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001281188.1 PFAM: DoxX family protein YP_001281189.1 PFAM: NAD(P)H dehydrogenase (quinone); NADPH-dependent FMN reductase YP_001281190.1 PFAM: protein of unknown function DUF1275 YP_001281191.1 PFAM: isochorismatase hydrolase YP_001281193.1 PFAM: Pirin domain protein domain protein YP_001281194.1 PFAM: Pirin domain protein domain protein; Pirin domain protein YP_001281196.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001281198.1 PFAM: pseudouridine synthase YP_001281199.1 TIGRFAM: thioredoxin; PFAM: Redoxin domain protein; Thioredoxin domain YP_001281200.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001281201.1 PFAM: 17 kDa surface antigen YP_001281202.1 PFAM: protein of unknown function, zinc metallopeptidase putative YP_001281204.1 PFAM: histone family protein DNA-binding protein YP_001281205.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001281206.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001281207.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001281208.1 PFAM: ribosomal protein L35 YP_001281209.1 PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase YP_001281210.1 TIGRFAM: twin-arginine translocation protein, TatA/E family subunit; PFAM: sec-independent translocation protein mttA/Hcf106 YP_001281211.1 TIGRFAM: twin-arginine translocation protein, TatB subunit YP_001281212.1 TIGRFAM: Sec-independent protein translocase, TatC subunit; PFAM: Sec-independent periplasmic protein translocase YP_001281214.1 PFAM: dihydrouridine synthase, DuS YP_001281216.1 PFAM: OsmC family protein YP_001281217.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: lipolytic enzyme, G-D-S-L family; Autotransporter beta- domain protein YP_001281218.1 hydrolyzes diadenosine polyphosphate YP_001281219.1 PFAM: protein of unknown function DUF833 YP_001281220.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001281221.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001281222.1 PFAM: dihydrofolate reductase region YP_001281223.1 PFAM: phospholipase D/Transphosphatidylase YP_001281224.1 PFAM: creatinase; peptidase M24 YP_001281225.1 TIGRFAM: amino acid/peptide transporter; PFAM: TGF-beta receptor, type I/II extracellular region; major facilitator superfamily MFS_1 YP_001281227.1 TIGRFAM: apolipoprotein N-acyltransferase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001281228.1 catalyzes branch migration in Holliday junction intermediates YP_001281229.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001281230.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001281231.1 PFAM: protein of unknown function DUF6, transmembrane YP_001281235.1 PFAM: N-acetyltransferase YP_001281237.1 PFAM: Appr-1-p processing domain protein YP_001281238.1 PFAM: FAD linked oxidase domain protein YP_001281239.1 PFAM: OmpW family protein YP_001281240.1 PFAM: MOSC domain containing protein YP_001281243.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein YP_001281244.1 PFAM: acriflavin resistance protein YP_001281245.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001281246.1 PFAM: cytochrome c, class I YP_001281247.1 PFAM: amine oxidase YP_001281248.1 PFAM: cytochrome c, class I YP_001281249.1 TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase, ChlI subunit; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001281250.1 PFAM: protein of unknown function DUF6, transmembrane YP_001281251.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001281252.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein YP_001281254.1 PFAM: band 7 protein YP_001281255.1 PFAM: protein of unknown function DUF107 YP_001281257.1 PFAM: OmpA domain protein transmembrane region-containing protein YP_001281258.1 PFAM: OmpA domain protein transmembrane region-containing protein YP_001281259.1 PFAM: OmpA domain protein transmembrane region-containing protein YP_001281260.1 PFAM: aminotransferase, class I and II YP_001281261.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001281262.1 PFAM: GrpE protein YP_001281265.1 PFAM: NAD-dependent epimerase/dehydratase; domain of unknown function DUF1731 YP_001281266.1 PFAM: SUA5/yciO/yrdC, N-terminal domain YP_001281267.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein YP_001281268.1 PFAM: Di-haem cytochrome c peroxidase YP_001281269.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001281270.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001281271.1 TIGRFAM: putative polyhydroxyalkanoic acid system protein YP_001281272.1 PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44 YP_001281273.1 TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein YP_001281274.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001281275.1 TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase, zinc-binding; bifunctional deaminase-reductase domain protein YP_001281276.1 PFAM: ATP-cone domain protein YP_001281277.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001281278.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001281279.1 PFAM: protein of unknown function DUF37 YP_001281280.1 TIGRFAM: ribonuclease P protein component; PFAM: ribonuclease P protein