-- dump date   	20140620_015856
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
996285000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
996285000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
996285000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285000004	Walker A motif; other site
996285000005	ATP binding site [chemical binding]; other site
996285000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
996285000007	Walker B motif; other site
996285000008	arginine finger; other site
996285000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
996285000010	DnaA box-binding interface [nucleotide binding]; other site
996285000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
996285000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
996285000013	putative DNA binding surface [nucleotide binding]; other site
996285000014	dimer interface [polypeptide binding]; other site
996285000015	beta-clamp/clamp loader binding surface; other site
996285000016	beta-clamp/translesion DNA polymerase binding surface; other site
996285000017	recombination protein F; Reviewed; Region: recF; PRK00064
996285000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285000019	Walker A/P-loop; other site
996285000020	ATP binding site [chemical binding]; other site
996285000021	Q-loop/lid; other site
996285000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285000023	ABC transporter signature motif; other site
996285000024	Walker B; other site
996285000025	D-loop; other site
996285000026	H-loop/switch region; other site
996285000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
996285000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000029	ATP binding site [chemical binding]; other site
996285000030	Mg2+ binding site [ion binding]; other site
996285000031	G-X-G motif; other site
996285000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
996285000033	anchoring element; other site
996285000034	dimer interface [polypeptide binding]; other site
996285000035	ATP binding site [chemical binding]; other site
996285000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
996285000037	active site
996285000038	putative metal-binding site [ion binding]; other site
996285000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
996285000040	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
996285000041	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
996285000042	catalytic residue [active]
996285000043	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
996285000044	catalytic residues [active]
996285000045	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285000046	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285000047	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
996285000048	heme-binding site [chemical binding]; other site
996285000049	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285000050	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285000051	metal binding site [ion binding]; metal-binding site
996285000052	active site
996285000053	I-site; other site
996285000054	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
996285000055	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
996285000056	putative acyl-acceptor binding pocket; other site
996285000057	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
996285000058	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285000059	active site
996285000060	motif I; other site
996285000061	motif II; other site
996285000062	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
996285000063	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
996285000064	HD domain; Region: HD; pfam01966
996285000065	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
996285000066	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
996285000067	dimer interface [polypeptide binding]; other site
996285000068	motif 1; other site
996285000069	active site
996285000070	motif 2; other site
996285000071	motif 3; other site
996285000072	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
996285000073	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
996285000074	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
996285000075	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
996285000076	putative acyl-acceptor binding pocket; other site
996285000077	PilZ domain; Region: PilZ; pfam07238
996285000078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285000079	TPR motif; other site
996285000080	Tetratricopeptide repeat; Region: TPR_16; pfam13432
996285000081	binding surface
996285000082	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
996285000083	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
996285000084	Walker A/P-loop; other site
996285000085	ATP binding site [chemical binding]; other site
996285000086	Q-loop/lid; other site
996285000087	ABC transporter signature motif; other site
996285000088	Walker B; other site
996285000089	D-loop; other site
996285000090	H-loop/switch region; other site
996285000091	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996285000092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285000093	dimer interface [polypeptide binding]; other site
996285000094	conserved gate region; other site
996285000095	putative PBP binding loops; other site
996285000096	ABC-ATPase subunit interface; other site
996285000097	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996285000098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285000099	dimer interface [polypeptide binding]; other site
996285000100	conserved gate region; other site
996285000101	putative PBP binding loops; other site
996285000102	ABC-ATPase subunit interface; other site
996285000103	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
996285000104	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285000105	substrate binding pocket [chemical binding]; other site
996285000106	membrane-bound complex binding site; other site
996285000107	hinge residues; other site
996285000108	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
996285000109	TrkA-N domain; Region: TrkA_N; pfam02254
996285000110	TrkA-C domain; Region: TrkA_C; pfam02080
996285000111	TrkA-N domain; Region: TrkA_N; pfam02254
996285000112	TrkA-C domain; Region: TrkA_C; pfam02080
996285000113	16S rRNA methyltransferase B; Provisional; Region: PRK10901
996285000114	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
996285000115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285000116	S-adenosylmethionine binding site [chemical binding]; other site
996285000117	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
996285000118	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
996285000119	putative active site [active]
996285000120	substrate binding site [chemical binding]; other site
996285000121	putative cosubstrate binding site; other site
996285000122	catalytic site [active]
996285000123	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
996285000124	substrate binding site [chemical binding]; other site
996285000125	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
996285000126	active site
996285000127	catalytic residues [active]
996285000128	metal binding site [ion binding]; metal-binding site
996285000129	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
996285000130	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285000131	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
996285000132	DNA protecting protein DprA; Region: dprA; TIGR00732
996285000133	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
996285000134	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
996285000135	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
996285000136	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
996285000137	NADP binding site [chemical binding]; other site
996285000138	dimer interface [polypeptide binding]; other site
996285000139	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
996285000140	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
996285000141	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
996285000142	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
996285000143	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
996285000144	shikimate binding site; other site
996285000145	NAD(P) binding site [chemical binding]; other site
996285000146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285000147	NADH(P)-binding; Region: NAD_binding_10; pfam13460
996285000148	NAD(P) binding site [chemical binding]; other site
996285000149	active site
996285000150	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
996285000151	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
996285000152	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
996285000153	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285000154	N-terminal plug; other site
996285000155	ligand-binding site [chemical binding]; other site
996285000156	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
996285000157	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
996285000158	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
996285000159	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
996285000160	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
996285000161	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
996285000162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285000163	dimer interface [polypeptide binding]; other site
996285000164	conserved gate region; other site
996285000165	ABC-ATPase subunit interface; other site
996285000166	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
996285000167	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
996285000168	Walker A/P-loop; other site
996285000169	ATP binding site [chemical binding]; other site
996285000170	Q-loop/lid; other site
996285000171	ABC transporter signature motif; other site
996285000172	Walker B; other site
996285000173	D-loop; other site
996285000174	H-loop/switch region; other site
996285000175	NIL domain; Region: NIL; pfam09383
996285000176	hydroperoxidase II; Provisional; Region: katE; PRK11249
996285000177	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
996285000178	tetramer interface [polypeptide binding]; other site
996285000179	heme binding pocket [chemical binding]; other site
996285000180	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
996285000181	domain interactions; other site
996285000182	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
996285000183	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996285000184	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996285000185	ABC-ATPase subunit  interface; other site
996285000186	dimer interface [polypeptide binding]; other site
996285000187	putative PBP binding regions; other site
996285000188	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
996285000189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285000190	Walker A/P-loop; other site
996285000191	ATP binding site [chemical binding]; other site
996285000192	Q-loop/lid; other site
996285000193	ABC transporter signature motif; other site
996285000194	Walker B; other site
996285000195	D-loop; other site
996285000196	H-loop/switch region; other site
996285000197	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
996285000198	metal binding site 2 [ion binding]; metal-binding site
996285000199	putative DNA binding helix; other site
996285000200	metal binding site 1 [ion binding]; metal-binding site
996285000201	dimer interface [polypeptide binding]; other site
996285000202	structural Zn2+ binding site [ion binding]; other site
996285000203	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
996285000204	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
996285000205	metal binding site [ion binding]; metal-binding site
996285000206	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285000207	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
996285000208	inhibitor-cofactor binding pocket; inhibition site
996285000209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285000210	catalytic residue [active]
996285000211	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
996285000212	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
996285000213	NAD(P) binding site [chemical binding]; other site
996285000214	catalytic residues [active]
996285000215	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
996285000216	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
996285000217	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
996285000218	DXD motif; other site
996285000219	HEAT repeats; Region: HEAT_2; pfam13646
996285000220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285000221	TPR motif; other site
996285000222	TPR repeat; Region: TPR_11; pfam13414
996285000223	binding surface
996285000224	Response regulator receiver domain; Region: Response_reg; pfam00072
996285000225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000226	active site
996285000227	phosphorylation site [posttranslational modification]
996285000228	intermolecular recognition site; other site
996285000229	dimerization interface [polypeptide binding]; other site
996285000230	CHASE3 domain; Region: CHASE3; pfam05227
996285000231	PAS domain S-box; Region: sensory_box; TIGR00229
996285000232	PAS domain; Region: PAS; smart00091
996285000233	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285000234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285000235	dimer interface [polypeptide binding]; other site
996285000236	phosphorylation site [posttranslational modification]
996285000237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000238	ATP binding site [chemical binding]; other site
996285000239	Mg2+ binding site [ion binding]; other site
996285000240	G-X-G motif; other site
996285000241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000242	active site
996285000243	phosphorylation site [posttranslational modification]
996285000244	intermolecular recognition site; other site
996285000245	dimerization interface [polypeptide binding]; other site
996285000246	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285000247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000248	active site
996285000249	phosphorylation site [posttranslational modification]
996285000250	intermolecular recognition site; other site
996285000251	dimerization interface [polypeptide binding]; other site
996285000252	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
996285000253	putative binding surface; other site
996285000254	active site
996285000255	Response regulator receiver domain; Region: Response_reg; pfam00072
996285000256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000257	active site
996285000258	phosphorylation site [posttranslational modification]
996285000259	intermolecular recognition site; other site
996285000260	dimerization interface [polypeptide binding]; other site
996285000261	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285000262	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285000263	metal binding site [ion binding]; metal-binding site
996285000264	active site
996285000265	I-site; other site
996285000266	Response regulator receiver domain; Region: Response_reg; pfam00072
996285000267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000268	active site
996285000269	phosphorylation site [posttranslational modification]
996285000270	intermolecular recognition site; other site
996285000271	dimerization interface [polypeptide binding]; other site
996285000272	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285000273	GAF domain; Region: GAF; pfam01590
996285000274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000275	PAS domain; Region: PAS_9; pfam13426
996285000276	putative active site [active]
996285000277	heme pocket [chemical binding]; other site
996285000278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000279	PAS fold; Region: PAS_3; pfam08447
996285000280	putative active site [active]
996285000281	heme pocket [chemical binding]; other site
996285000282	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996285000283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000284	putative active site [active]
996285000285	heme pocket [chemical binding]; other site
996285000286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285000287	dimer interface [polypeptide binding]; other site
996285000288	phosphorylation site [posttranslational modification]
996285000289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000290	ATP binding site [chemical binding]; other site
996285000291	Mg2+ binding site [ion binding]; other site
996285000292	G-X-G motif; other site
996285000293	Response regulator receiver domain; Region: Response_reg; pfam00072
996285000294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000295	active site
996285000296	phosphorylation site [posttranslational modification]
996285000297	intermolecular recognition site; other site
996285000298	dimerization interface [polypeptide binding]; other site
996285000299	PAS fold; Region: PAS_3; pfam08447
996285000300	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000301	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
996285000302	putative active site [active]
996285000303	heme pocket [chemical binding]; other site
996285000304	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996285000305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000306	putative active site [active]
996285000307	heme pocket [chemical binding]; other site
996285000308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000309	ATP binding site [chemical binding]; other site
996285000310	Mg2+ binding site [ion binding]; other site
996285000311	G-X-G motif; other site
996285000312	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
996285000313	Fatty acid desaturase; Region: FA_desaturase; pfam00487
996285000314	Di-iron ligands [ion binding]; other site
996285000315	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285000316	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000317	PAS fold; Region: PAS_3; pfam08447
996285000318	putative active site [active]
996285000319	heme pocket [chemical binding]; other site
996285000320	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285000321	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285000322	metal binding site [ion binding]; metal-binding site
996285000323	active site
996285000324	I-site; other site
996285000325	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
996285000326	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285000327	active site
996285000328	agmatine deiminase; Provisional; Region: PRK13551
996285000329	agmatine deiminase; Region: agmatine_aguA; TIGR03380
996285000330	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
996285000331	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
996285000332	putative active site; other site
996285000333	catalytic triad [active]
996285000334	putative dimer interface [polypeptide binding]; other site
996285000335	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285000336	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285000337	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
996285000338	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
996285000339	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
996285000340	Peptidase C26; Region: Peptidase_C26; pfam07722
996285000341	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
996285000342	catalytic triad [active]
996285000343	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
996285000344	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
996285000345	putative aminotransferase; Validated; Region: PRK07480
996285000346	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285000347	inhibitor-cofactor binding pocket; inhibition site
996285000348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285000349	catalytic residue [active]
996285000350	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
996285000351	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
996285000352	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
996285000353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
996285000354	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
996285000355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285000356	Walker A/P-loop; other site
996285000357	ATP binding site [chemical binding]; other site
996285000358	Q-loop/lid; other site
996285000359	ABC transporter signature motif; other site
996285000360	Walker B; other site
996285000361	D-loop; other site
996285000362	H-loop/switch region; other site
996285000363	TOBE domain; Region: TOBE_2; pfam08402
996285000364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285000365	dimer interface [polypeptide binding]; other site
996285000366	conserved gate region; other site
996285000367	putative PBP binding loops; other site
996285000368	ABC-ATPase subunit interface; other site
996285000369	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
996285000370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285000371	dimer interface [polypeptide binding]; other site
996285000372	conserved gate region; other site
996285000373	putative PBP binding loops; other site
996285000374	ABC-ATPase subunit interface; other site
996285000375	NnrS protein; Region: NnrS; pfam05940
996285000376	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
996285000377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285000378	Walker A/P-loop; other site
996285000379	ATP binding site [chemical binding]; other site
996285000380	Q-loop/lid; other site
996285000381	ABC transporter signature motif; other site
996285000382	Walker B; other site
996285000383	D-loop; other site
996285000384	H-loop/switch region; other site
996285000385	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285000386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285000387	dimer interface [polypeptide binding]; other site
996285000388	conserved gate region; other site
996285000389	putative PBP binding loops; other site
996285000390	ABC-ATPase subunit interface; other site
996285000391	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285000392	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
996285000393	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285000394	N-terminal plug; other site
996285000395	ligand-binding site [chemical binding]; other site
996285000396	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
996285000397	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996285000398	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
996285000399	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
996285000400	DctM-like transporters; Region: DctM; pfam06808
996285000401	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
996285000402	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
996285000403	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285000404	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285000405	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285000406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000407	active site
996285000408	phosphorylation site [posttranslational modification]
996285000409	intermolecular recognition site; other site
996285000410	dimerization interface [polypeptide binding]; other site
996285000411	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285000412	Walker A motif; other site
996285000413	ATP binding site [chemical binding]; other site
996285000414	Walker B motif; other site
996285000415	arginine finger; other site
996285000416	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285000417	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
996285000418	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285000419	dimer interface [polypeptide binding]; other site
996285000420	phosphorylation site [posttranslational modification]
996285000421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000422	ATP binding site [chemical binding]; other site
996285000423	G-X-G motif; other site
996285000424	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
996285000425	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
996285000426	NADP binding site [chemical binding]; other site
996285000427	active site
996285000428	putative substrate binding site [chemical binding]; other site
996285000429	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
996285000430	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
996285000431	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
996285000432	substrate binding site; other site
996285000433	tetramer interface; other site
996285000434	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
996285000435	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
996285000436	NAD binding site [chemical binding]; other site
996285000437	substrate binding site [chemical binding]; other site
996285000438	homodimer interface [polypeptide binding]; other site
996285000439	active site
996285000440	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
996285000441	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
996285000442	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
996285000443	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996285000444	Walker A/P-loop; other site
996285000445	ATP binding site [chemical binding]; other site
996285000446	Q-loop/lid; other site
996285000447	ABC transporter signature motif; other site
996285000448	Walker B; other site
996285000449	D-loop; other site
996285000450	H-loop/switch region; other site
996285000451	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996285000452	Walker A/P-loop; other site
996285000453	ATP binding site [chemical binding]; other site
996285000454	Q-loop/lid; other site
996285000455	ABC transporter signature motif; other site
996285000456	Walker B; other site
996285000457	D-loop; other site
996285000458	H-loop/switch region; other site
996285000459	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
996285000460	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
996285000461	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285000462	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285000463	Protein of unknown function (DUF330); Region: DUF330; cl01135
996285000464	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
996285000465	mce related protein; Region: MCE; pfam02470
996285000466	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
996285000467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285000468	Walker A/P-loop; other site
996285000469	ATP binding site [chemical binding]; other site
996285000470	Q-loop/lid; other site
996285000471	ABC transporter signature motif; other site
996285000472	Walker B; other site
996285000473	D-loop; other site
996285000474	H-loop/switch region; other site
996285000475	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
996285000476	Permease; Region: Permease; pfam02405
996285000477	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
996285000478	putative heme binding pocket [chemical binding]; other site
996285000479	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
996285000480	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
996285000481	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
996285000482	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
996285000483	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996285000484	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996285000485	active site
996285000486	ATP binding site [chemical binding]; other site
996285000487	substrate binding site [chemical binding]; other site
996285000488	activation loop (A-loop); other site
996285000489	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
996285000490	active site
996285000491	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
996285000492	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
996285000493	G1 box; other site
996285000494	GTP/Mg2+ binding site [chemical binding]; other site
996285000495	G2 box; other site
996285000496	Switch I region; other site
996285000497	G3 box; other site
996285000498	Switch II region; other site
996285000499	G4 box; other site
996285000500	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
996285000501	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
996285000502	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
996285000503	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
996285000504	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
996285000505	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
996285000506	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
996285000507	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
996285000508	phosphopeptide binding site; other site
996285000509	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
996285000510	Cytochrome C' Region: Cytochrom_C_2; pfam01322
996285000511	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
996285000512	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
996285000513	tetramerization interface [polypeptide binding]; other site
996285000514	NAD(P) binding site [chemical binding]; other site
996285000515	catalytic residues [active]
996285000516	Response regulator receiver domain; Region: Response_reg; pfam00072
996285000517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000518	active site
996285000519	phosphorylation site [posttranslational modification]
996285000520	intermolecular recognition site; other site
996285000521	dimerization interface [polypeptide binding]; other site
996285000522	HDOD domain; Region: HDOD; pfam08668
996285000523	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
996285000524	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285000525	substrate binding site [chemical binding]; other site
996285000526	oxyanion hole (OAH) forming residues; other site
996285000527	trimer interface [polypeptide binding]; other site
996285000528	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
996285000529	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285000530	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285000531	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
996285000532	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
996285000533	FAD binding site [chemical binding]; other site
996285000534	substrate binding site [chemical binding]; other site
996285000535	catalytic base [active]
996285000536	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
996285000537	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
996285000538	active site
996285000539	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
996285000540	Bacterial SH3 domain; Region: SH3_3; pfam08239
996285000541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285000542	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285000543	putative substrate translocation pore; other site
996285000544	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
996285000545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285000546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285000547	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
996285000548	Transcriptional regulator [Transcription]; Region: IclR; COG1414
996285000549	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
996285000550	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
996285000551	acyl-activating enzyme (AAE) consensus motif; other site
996285000552	putative AMP binding site [chemical binding]; other site
996285000553	putative active site [active]
996285000554	putative CoA binding site [chemical binding]; other site
996285000555	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
996285000556	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
996285000557	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
996285000558	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
996285000559	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
996285000560	active site
996285000561	dimer interface [polypeptide binding]; other site
996285000562	effector binding site; other site
996285000563	TSCPD domain; Region: TSCPD; pfam12637
996285000564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285000565	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285000566	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
996285000567	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
996285000568	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
996285000569	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
996285000570	putative active site [active]
996285000571	putative substrate binding site [chemical binding]; other site
996285000572	ATP binding site [chemical binding]; other site
996285000573	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
996285000574	DNA polymerase I; Provisional; Region: PRK05755
996285000575	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
996285000576	active site
996285000577	metal binding site 1 [ion binding]; metal-binding site
996285000578	putative 5' ssDNA interaction site; other site
996285000579	metal binding site 3; metal-binding site
996285000580	metal binding site 2 [ion binding]; metal-binding site
996285000581	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
996285000582	putative DNA binding site [nucleotide binding]; other site
996285000583	putative metal binding site [ion binding]; other site
996285000584	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
996285000585	active site
996285000586	catalytic site [active]
996285000587	substrate binding site [chemical binding]; other site
996285000588	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
996285000589	active site
996285000590	DNA binding site [nucleotide binding]
996285000591	catalytic site [active]
996285000592	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
996285000593	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
996285000594	conserverd hypothetical protein; Region: TIGR02448
996285000595	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
996285000596	Predicted membrane protein [Function unknown]; Region: COG2855
996285000597	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
996285000598	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285000599	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
996285000600	putative dimerization interface [polypeptide binding]; other site
996285000601	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
996285000602	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
996285000603	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
996285000604	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
996285000605	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
996285000606	ligand binding site [chemical binding]; other site
996285000607	homodimer interface [polypeptide binding]; other site
996285000608	NAD(P) binding site [chemical binding]; other site
996285000609	trimer interface B [polypeptide binding]; other site
996285000610	trimer interface A [polypeptide binding]; other site
996285000611	type II secretion system protein E; Region: type_II_gspE; TIGR02533
996285000612	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
996285000613	Walker A motif; other site
996285000614	ATP binding site [chemical binding]; other site
996285000615	Walker B motif; other site
996285000616	type II secretion system protein F; Region: GspF; TIGR02120
996285000617	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
996285000618	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
996285000619	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
996285000620	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
996285000621	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
996285000622	type II secretion system protein I; Region: gspI; TIGR01707
996285000623	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
996285000624	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
996285000625	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
996285000626	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
996285000627	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
996285000628	GspL periplasmic domain; Region: GspL_C; pfam12693
996285000629	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
996285000630	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
996285000631	putative deacylase active site [active]
996285000632	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
996285000633	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
996285000634	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
996285000635	generic binding surface II; other site
996285000636	ssDNA binding site; other site
996285000637	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285000638	ATP binding site [chemical binding]; other site
996285000639	putative Mg++ binding site [ion binding]; other site
996285000640	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285000641	nucleotide binding region [chemical binding]; other site
996285000642	ATP-binding site [chemical binding]; other site
996285000643	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
996285000644	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285000645	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
996285000646	dimerization interface [polypeptide binding]; other site
996285000647	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
996285000648	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
996285000649	putative NAD(P) binding site [chemical binding]; other site
996285000650	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
996285000651	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
996285000652	NAD binding site [chemical binding]; other site
996285000653	catalytic Zn binding site [ion binding]; other site
996285000654	structural Zn binding site [ion binding]; other site
996285000655	Predicted permeases [General function prediction only]; Region: COG0679
996285000656	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
996285000657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285000658	S-adenosylmethionine binding site [chemical binding]; other site
996285000659	PilZ domain; Region: PilZ; pfam07238
996285000660	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
996285000661	FHIPEP family; Region: FHIPEP; pfam00771
996285000662	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
996285000663	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
996285000664	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
996285000665	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
996285000666	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
996285000667	flagellar motor switch protein FliN; Region: fliN; TIGR02480
996285000668	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
996285000669	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285000670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
996285000671	active site
996285000672	phosphorylation site [posttranslational modification]
996285000673	intermolecular recognition site; other site
996285000674	dimerization interface [polypeptide binding]; other site
996285000675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285000676	Walker A motif; other site
996285000677	ATP binding site [chemical binding]; other site
996285000678	Walker B motif; other site
996285000679	arginine finger; other site
996285000680	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285000681	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
996285000682	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
996285000683	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
996285000684	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
996285000685	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
996285000686	MgtE intracellular N domain; Region: MgtE_N; smart00924
996285000687	FliG C-terminal domain; Region: FliG_C; pfam01706
996285000688	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
996285000689	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
996285000690	Flagellar assembly protein FliH; Region: FliH; pfam02108
996285000691	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
996285000692	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
996285000693	Walker A motif/ATP binding site; other site
996285000694	Walker B motif; other site
996285000695	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
996285000696	FlgN protein; Region: FlgN; pfam05130
996285000697	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
996285000698	flagellar capping protein; Reviewed; Region: fliD; PRK08032
996285000699	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
996285000700	Flagellar protein FliS; Region: FliS; cl00654
996285000701	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
996285000702	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
996285000703	flagellar biosynthesis sigma factor; Provisional; Region: PRK12427
996285000704	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285000705	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
996285000706	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285000707	DNA binding residues [nucleotide binding]
996285000708	flagellar motor protein MotA; Provisional; Region: PRK12482
996285000709	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
996285000710	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
996285000711	hypothetical protein; Validated; Region: PRK06778
996285000712	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285000713	ligand binding site [chemical binding]; other site
996285000714	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
996285000715	DNA binding site [nucleotide binding]
996285000716	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285000717	flagellin; Reviewed; Region: PRK08869
996285000718	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
996285000719	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
996285000720	SAF-like; Region: SAF_2; pfam13144
996285000721	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
996285000722	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
996285000723	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
996285000724	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
996285000725	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
996285000726	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
996285000727	Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673
996285000728	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285000729	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
996285000730	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619
996285000731	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
996285000732	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
996285000733	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
996285000734	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
996285000735	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285000736	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
996285000737	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
996285000738	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
996285000739	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285000740	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407
996285000741	Flagellar L-ring protein; Region: FlgH; pfam02107
996285000742	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
996285000743	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
996285000744	Rod binding protein; Region: Rod-binding; cl01626
996285000745	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
996285000746	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285000747	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285000748	catalytic residue [active]
996285000749	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
996285000750	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285000751	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
996285000752	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
996285000753	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
996285000754	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285000755	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
996285000756	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
996285000757	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
996285000758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000759	putative active site [active]
996285000760	heme pocket [chemical binding]; other site
996285000761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285000762	dimer interface [polypeptide binding]; other site
996285000763	phosphorylation site [posttranslational modification]
996285000764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000765	ATP binding site [chemical binding]; other site
996285000766	Mg2+ binding site [ion binding]; other site
996285000767	G-X-G motif; other site
996285000768	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285000769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000770	active site
996285000771	phosphorylation site [posttranslational modification]
996285000772	intermolecular recognition site; other site
996285000773	dimerization interface [polypeptide binding]; other site
996285000774	Response regulator receiver domain; Region: Response_reg; pfam00072
996285000775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000776	active site
996285000777	phosphorylation site [posttranslational modification]
996285000778	intermolecular recognition site; other site
996285000779	dimerization interface [polypeptide binding]; other site
996285000780	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
996285000781	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
996285000782	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
996285000783	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
996285000784	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285000785	N-terminal plug; other site
996285000786	ligand-binding site [chemical binding]; other site
996285000787	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
996285000788	SnoaL-like domain; Region: SnoaL_3; pfam13474
996285000789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
996285000790	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
996285000791	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285000792	DNA binding residues [nucleotide binding]
996285000793	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285000794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285000795	active site
996285000796	phosphorylation site [posttranslational modification]
996285000797	intermolecular recognition site; other site
996285000798	dimerization interface [polypeptide binding]; other site
996285000799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285000800	Walker A motif; other site
996285000801	ATP binding site [chemical binding]; other site
996285000802	Walker B motif; other site
996285000803	arginine finger; other site
996285000804	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285000805	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
996285000806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285000807	dimer interface [polypeptide binding]; other site
996285000808	phosphorylation site [posttranslational modification]
996285000809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000810	ATP binding site [chemical binding]; other site
996285000811	Mg2+ binding site [ion binding]; other site
996285000812	G-X-G motif; other site
996285000813	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
996285000814	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
996285000815	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996285000816	Zn2+ binding site [ion binding]; other site
996285000817	Mg2+ binding site [ion binding]; other site
996285000818	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285000819	Ligand Binding Site [chemical binding]; other site
996285000820	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285000821	Ligand Binding Site [chemical binding]; other site
996285000822	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
996285000823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285000824	S-adenosylmethionine binding site [chemical binding]; other site
996285000825	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
996285000826	glycine cleavage system protein H; Provisional; Region: PRK13380
996285000827	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
996285000828	lipoyl attachment site [posttranslational modification]; other site
996285000829	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
996285000830	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
996285000831	G1 box; other site
996285000832	putative GEF interaction site [polypeptide binding]; other site
996285000833	GTP/Mg2+ binding site [chemical binding]; other site
996285000834	Switch I region; other site
996285000835	G2 box; other site
996285000836	G3 box; other site
996285000837	Switch II region; other site
996285000838	G4 box; other site
996285000839	G5 box; other site
996285000840	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
996285000841	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
996285000842	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
996285000843	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
996285000844	selenocysteine synthase; Provisional; Region: PRK04311
996285000845	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
996285000846	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
996285000847	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285000848	catalytic residue [active]
996285000849	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
996285000850	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
996285000851	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
996285000852	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
996285000853	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
996285000854	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
996285000855	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285000856	molybdopterin cofactor binding site; other site
996285000857	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285000858	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
996285000859	molybdopterin cofactor binding site; other site
996285000860	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285000861	Cupin; Region: Cupin_6; pfam12852
996285000862	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285000863	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285000864	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285000865	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
996285000866	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
996285000867	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
996285000868	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996285000869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
996285000870	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285000871	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
996285000872	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
996285000873	Part of AAA domain; Region: AAA_19; pfam13245
996285000874	Family description; Region: UvrD_C_2; pfam13538
996285000875	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
996285000876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000877	putative active site [active]
996285000878	heme pocket [chemical binding]; other site
996285000879	RNase II stability modulator; Provisional; Region: PRK10060
996285000880	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000881	putative active site [active]
996285000882	heme pocket [chemical binding]; other site
996285000883	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285000884	metal binding site [ion binding]; metal-binding site
996285000885	active site
996285000886	I-site; other site
996285000887	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285000888	putative protease; Provisional; Region: PRK15452
996285000889	Peptidase family U32; Region: Peptidase_U32; pfam01136
996285000890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
996285000891	aspartate kinase; Validated; Region: PRK09181
996285000892	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
996285000893	nucleotide binding site [chemical binding]; other site
996285000894	substrate binding site [chemical binding]; other site
996285000895	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910
996285000896	allosteric regulatory residue; other site
996285000897	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
996285000898	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
996285000899	Ectoine synthase; Region: Ectoine_synth; pfam06339
996285000900	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
996285000901	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285000902	inhibitor-cofactor binding pocket; inhibition site
996285000903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285000904	catalytic residue [active]
996285000905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285000906	Coenzyme A binding pocket [chemical binding]; other site
996285000907	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
996285000908	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
996285000909	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
996285000910	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
996285000911	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
996285000912	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
996285000913	putative active site [active]
996285000914	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285000915	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285000916	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
996285000917	putative dimerization interface [polypeptide binding]; other site
996285000918	pyruvate carboxylase subunit A; Validated; Region: PRK07178
996285000919	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996285000920	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
996285000921	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
996285000922	pyruvate carboxylase subunit B; Validated; Region: PRK09282
996285000923	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
996285000924	active site
996285000925	catalytic residues [active]
996285000926	metal binding site [ion binding]; metal-binding site
996285000927	homodimer binding site [polypeptide binding]; other site
996285000928	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996285000929	carboxyltransferase (CT) interaction site; other site
996285000930	biotinylation site [posttranslational modification]; other site
996285000931	Domain of unknown function (DUF897); Region: DUF897; cl01312
996285000932	glutaminase; Provisional; Region: PRK00971
996285000933	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
996285000934	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
996285000935	active site clefts [active]
996285000936	zinc binding site [ion binding]; other site
996285000937	dimer interface [polypeptide binding]; other site
996285000938	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285000939	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
996285000940	active site
996285000941	homodimer interface [polypeptide binding]; other site
996285000942	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
996285000943	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
996285000944	Helix-turn-helix domain; Region: HTH_19; pfam12844
996285000945	non-specific DNA binding site [nucleotide binding]; other site
996285000946	salt bridge; other site
996285000947	sequence-specific DNA binding site [nucleotide binding]; other site
996285000948	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
996285000949	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
996285000950	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
996285000951	Aspartase; Region: Aspartase; cd01357
996285000952	active sites [active]
996285000953	tetramer interface [polypeptide binding]; other site
996285000954	cell density-dependent motility repressor; Provisional; Region: PRK10082
996285000955	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285000956	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
996285000957	dimerization interface [polypeptide binding]; other site
996285000958	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
996285000959	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996285000960	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
996285000961	acyl-activating enzyme (AAE) consensus motif; other site
996285000962	putative AMP binding site [chemical binding]; other site
996285000963	putative active site [active]
996285000964	putative CoA binding site [chemical binding]; other site
996285000965	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
996285000966	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
996285000967	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
996285000968	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
996285000969	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
996285000970	dimer interface [polypeptide binding]; other site
996285000971	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
996285000972	active site
996285000973	Fe binding site [ion binding]; other site
996285000974	Cache domain; Region: Cache_1; pfam02743
996285000975	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
996285000976	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
996285000977	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285000978	putative active site [active]
996285000979	heme pocket [chemical binding]; other site
996285000980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285000981	dimer interface [polypeptide binding]; other site
996285000982	phosphorylation site [posttranslational modification]
996285000983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285000984	ATP binding site [chemical binding]; other site
996285000985	Mg2+ binding site [ion binding]; other site
996285000986	G-X-G motif; other site
996285000987	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
996285000988	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
996285000989	ATP-grasp domain; Region: ATP-grasp; pfam02222
996285000990	Predicted membrane protein [Function unknown]; Region: COG2261
996285000991	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
996285000992	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
996285000993	active site
996285000994	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
996285000995	active site
996285000996	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
996285000997	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
996285000998	putative ligand binding site [chemical binding]; other site
996285000999	putative NAD binding site [chemical binding]; other site
996285001000	catalytic site [active]
996285001001	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
996285001002	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
996285001003	Walker A/P-loop; other site
996285001004	ATP binding site [chemical binding]; other site
996285001005	Q-loop/lid; other site
996285001006	ABC transporter signature motif; other site
996285001007	Walker B; other site
996285001008	D-loop; other site
996285001009	H-loop/switch region; other site
996285001010	TOBE-like domain; Region: TOBE_3; pfam12857
996285001011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285001012	dimer interface [polypeptide binding]; other site
996285001013	conserved gate region; other site
996285001014	putative PBP binding loops; other site
996285001015	ABC-ATPase subunit interface; other site
996285001016	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
996285001017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285001018	dimer interface [polypeptide binding]; other site
996285001019	conserved gate region; other site
996285001020	putative PBP binding loops; other site
996285001021	ABC-ATPase subunit interface; other site
996285001022	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
996285001023	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285001024	substrate binding pocket [chemical binding]; other site
996285001025	membrane-bound complex binding site; other site
996285001026	hinge residues; other site
996285001027	Uncharacterized small protein [Function unknown]; Region: COG5583
996285001028	Serine hydrolase; Region: Ser_hydrolase; pfam06821
996285001029	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996285001030	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
996285001031	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
996285001032	dimer interface [polypeptide binding]; other site
996285001033	decamer (pentamer of dimers) interface [polypeptide binding]; other site
996285001034	catalytic triad [active]
996285001035	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
996285001036	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996285001037	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
996285001038	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285001039	substrate binding pocket [chemical binding]; other site
996285001040	membrane-bound complex binding site; other site
996285001041	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
996285001042	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
996285001043	active site
996285001044	dimer interface [polypeptide binding]; other site
996285001045	non-prolyl cis peptide bond; other site
996285001046	insertion regions; other site
996285001047	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285001048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285001049	dimer interface [polypeptide binding]; other site
996285001050	conserved gate region; other site
996285001051	putative PBP binding loops; other site
996285001052	ABC-ATPase subunit interface; other site
996285001053	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
996285001054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285001055	Walker A/P-loop; other site
996285001056	ATP binding site [chemical binding]; other site
996285001057	Q-loop/lid; other site
996285001058	ABC transporter signature motif; other site
996285001059	Walker B; other site
996285001060	D-loop; other site
996285001061	H-loop/switch region; other site
996285001062	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
996285001063	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
996285001064	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
996285001065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285001066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285001067	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285001068	putative effector binding pocket; other site
996285001069	dimerization interface [polypeptide binding]; other site
996285001070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285001071	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
996285001072	Transposase domain (DUF772); Region: DUF772; pfam05598
996285001073	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285001074	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285001075	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
996285001076	putative active site [active]
996285001077	catalytic site [active]
996285001078	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996285001079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285001080	ATP binding site [chemical binding]; other site
996285001081	putative Mg++ binding site [ion binding]; other site
996285001082	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285001083	nucleotide binding region [chemical binding]; other site
996285001084	ATP-binding site [chemical binding]; other site
996285001085	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
996285001086	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
996285001087	DNA methylase; Region: N6_N4_Mtase; pfam01555
996285001088	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
996285001089	BRO family, N-terminal domain; Region: Bro-N; pfam02498
996285001090	Restriction endonuclease [Defense mechanisms]; Region: COG3587
996285001091	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285001092	ATP binding site [chemical binding]; other site
996285001093	putative Mg++ binding site [ion binding]; other site
996285001094	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
996285001095	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
996285001096	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
996285001097	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
996285001098	DNA binding residues [nucleotide binding]
996285001099	dimer interface [polypeptide binding]; other site
996285001100	putative metal binding site [ion binding]; other site
996285001101	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
996285001102	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
996285001103	DNA binding residues [nucleotide binding]
996285001104	dimer interface [polypeptide binding]; other site
996285001105	putative metal binding site [ion binding]; other site
996285001106	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
996285001107	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
996285001108	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
996285001109	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
996285001110	putative active site [active]
996285001111	catalytic triad [active]
996285001112	putative dimer interface [polypeptide binding]; other site
996285001113	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285001114	Transposase domain (DUF772); Region: DUF772; pfam05598
996285001115	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285001116	Protein of unknown function (DUF 659); Region: DUF659; pfam04937
996285001117	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285001118	Transposase domain (DUF772); Region: DUF772; pfam05598
996285001119	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285001120	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285001121	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285001122	Methyltransferase domain; Region: Methyltransf_32; pfam13679
996285001123	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
996285001124	DctM-like transporters; Region: DctM; pfam06808
996285001125	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
996285001126	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285001127	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
996285001128	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
996285001129	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
996285001130	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285001131	PAS domain S-box; Region: sensory_box; TIGR00229
996285001132	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001133	putative active site [active]
996285001134	heme pocket [chemical binding]; other site
996285001135	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001136	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
996285001137	putative active site [active]
996285001138	heme pocket [chemical binding]; other site
996285001139	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001140	putative active site [active]
996285001141	heme pocket [chemical binding]; other site
996285001142	PAS fold; Region: PAS_3; pfam08447
996285001143	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285001144	GAF domain; Region: GAF; pfam01590
996285001145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001146	PAS domain; Region: PAS_9; pfam13426
996285001147	putative active site [active]
996285001148	heme pocket [chemical binding]; other site
996285001149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285001150	dimer interface [polypeptide binding]; other site
996285001151	phosphorylation site [posttranslational modification]
996285001152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001153	ATP binding site [chemical binding]; other site
996285001154	Mg2+ binding site [ion binding]; other site
996285001155	G-X-G motif; other site
996285001156	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285001157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001158	active site
996285001159	phosphorylation site [posttranslational modification]
996285001160	intermolecular recognition site; other site
996285001161	dimerization interface [polypeptide binding]; other site
996285001162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
996285001163	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
996285001164	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
996285001165	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
996285001166	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
996285001167	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
996285001168	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285001169	Walker A motif; other site
996285001170	ATP binding site [chemical binding]; other site
996285001171	Walker B motif; other site
996285001172	Uncharacterized conserved protein [Function unknown]; Region: COG3025
996285001173	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
996285001174	putative active site [active]
996285001175	putative metal binding residues [ion binding]; other site
996285001176	signature motif; other site
996285001177	putative triphosphate binding site [ion binding]; other site
996285001178	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
996285001179	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
996285001180	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
996285001181	acetylornithine deacetylase; Provisional; Region: PRK05111
996285001182	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
996285001183	metal binding site [ion binding]; metal-binding site
996285001184	putative dimer interface [polypeptide binding]; other site
996285001185	N-acetylglutamate synthase; Validated; Region: PRK05279
996285001186	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
996285001187	putative feedback inhibition sensing region; other site
996285001188	putative nucleotide binding site [chemical binding]; other site
996285001189	putative substrate binding site [chemical binding]; other site
996285001190	N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246
996285001191	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
996285001192	glutamate--cysteine ligase; Provisional; Region: PRK02107
996285001193	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996285001194	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
996285001195	CoenzymeA binding site [chemical binding]; other site
996285001196	subunit interaction site [polypeptide binding]; other site
996285001197	PHB binding site; other site
996285001198	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
996285001199	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
996285001200	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
996285001201	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
996285001202	RNA binding site [nucleotide binding]; other site
996285001203	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
996285001204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285001205	binding surface
996285001206	TPR motif; other site
996285001207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285001208	binding surface
996285001209	TPR motif; other site
996285001210	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
996285001211	cellulose synthase regulator protein; Provisional; Region: PRK11114
996285001212	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
996285001213	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
996285001214	DXD motif; other site
996285001215	PilZ domain; Region: PilZ; pfam07238
996285001216	YhjQ protein; Region: YhjQ; pfam06564
996285001217	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996285001218	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
996285001219	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
996285001220	Protein of unknown function (DUF2636); Region: DUF2636; cl11897
996285001221	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
996285001222	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
996285001223	osmolarity response regulator; Provisional; Region: ompR; PRK09468
996285001224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001225	active site
996285001226	phosphorylation site [posttranslational modification]
996285001227	intermolecular recognition site; other site
996285001228	dimerization interface [polypeptide binding]; other site
996285001229	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285001230	DNA binding site [nucleotide binding]
996285001231	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
996285001232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285001233	dimerization interface [polypeptide binding]; other site
996285001234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001235	ATP binding site [chemical binding]; other site
996285001236	Mg2+ binding site [ion binding]; other site
996285001237	G-X-G motif; other site
996285001238	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
996285001239	RimK-like ATP-grasp domain; Region: RimK; pfam08443
996285001240	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
996285001241	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285001242	RNA binding surface [nucleotide binding]; other site
996285001243	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
996285001244	active site
996285001245	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
996285001246	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
996285001247	dimerization interface [polypeptide binding]; other site
996285001248	domain crossover interface; other site
996285001249	redox-dependent activation switch; other site
996285001250	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
996285001251	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
996285001252	active site
996285001253	substrate-binding site [chemical binding]; other site
996285001254	metal-binding site [ion binding]
996285001255	ATP binding site [chemical binding]; other site
996285001256	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
996285001257	dimer interface [polypeptide binding]; other site
996285001258	FMN binding site [chemical binding]; other site
996285001259	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
996285001260	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
996285001261	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285001262	ATP binding site [chemical binding]; other site
996285001263	putative Mg++ binding site [ion binding]; other site
996285001264	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285001265	nucleotide binding region [chemical binding]; other site
996285001266	ATP-binding site [chemical binding]; other site
996285001267	FIST N domain; Region: FIST; smart00897
996285001268	FIST C domain; Region: FIST_C; pfam10442
996285001269	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285001270	dimer interface [polypeptide binding]; other site
996285001271	putative CheW interface [polypeptide binding]; other site
996285001272	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
996285001273	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285001274	dimerization interface [polypeptide binding]; other site
996285001275	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285001276	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285001277	dimer interface [polypeptide binding]; other site
996285001278	putative CheW interface [polypeptide binding]; other site
996285001279	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996285001280	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996285001281	active site
996285001282	catalytic tetrad [active]
996285001283	TLC ATP/ADP transporter; Region: TLC; cl03940
996285001284	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
996285001285	30S subunit binding site; other site
996285001286	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
996285001287	active site
996285001288	catalytic residues [active]
996285001289	Response regulator receiver domain; Region: Response_reg; pfam00072
996285001290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001291	active site
996285001292	phosphorylation site [posttranslational modification]
996285001293	intermolecular recognition site; other site
996285001294	dimerization interface [polypeptide binding]; other site
996285001295	PAS domain S-box; Region: sensory_box; TIGR00229
996285001296	PAS domain; Region: PAS; smart00091
996285001297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001298	ATP binding site [chemical binding]; other site
996285001299	Mg2+ binding site [ion binding]; other site
996285001300	G-X-G motif; other site
996285001301	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285001302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001303	active site
996285001304	phosphorylation site [posttranslational modification]
996285001305	intermolecular recognition site; other site
996285001306	dimerization interface [polypeptide binding]; other site
996285001307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285001308	dimer interface [polypeptide binding]; other site
996285001309	phosphorylation site [posttranslational modification]
996285001310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001311	ATP binding site [chemical binding]; other site
996285001312	Mg2+ binding site [ion binding]; other site
996285001313	G-X-G motif; other site
996285001314	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
996285001315	ATP binding site [chemical binding]; other site
996285001316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
996285001317	Mg2+ binding site [ion binding]; other site
996285001318	G-X-G motif; other site
996285001319	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
996285001320	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
996285001321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
996285001322	ATP binding site [chemical binding]; other site
996285001323	Mg2+ binding site [ion binding]; other site
996285001324	G-X-G motif; other site
996285001325	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
996285001326	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
996285001327	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
996285001328	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285001329	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285001330	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285001331	dimerization interface [polypeptide binding]; other site
996285001332	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
996285001333	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
996285001334	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285001335	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285001336	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
996285001337	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
996285001338	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285001339	active site
996285001340	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
996285001341	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
996285001342	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
996285001343	putative active site [active]
996285001344	metal binding site [ion binding]; metal-binding site
996285001345	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
996285001346	active site
996285001347	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
996285001348	PAS fold; Region: PAS_3; pfam08447
996285001349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001350	heme pocket [chemical binding]; other site
996285001351	putative active site [active]
996285001352	PAS fold; Region: PAS_4; pfam08448
996285001353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001354	putative active site [active]
996285001355	heme pocket [chemical binding]; other site
996285001356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285001357	dimer interface [polypeptide binding]; other site
996285001358	phosphorylation site [posttranslational modification]
996285001359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001360	ATP binding site [chemical binding]; other site
996285001361	Mg2+ binding site [ion binding]; other site
996285001362	G-X-G motif; other site
996285001363	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285001364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001365	active site
996285001366	phosphorylation site [posttranslational modification]
996285001367	intermolecular recognition site; other site
996285001368	dimerization interface [polypeptide binding]; other site
996285001369	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
996285001370	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
996285001371	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285001372	motif II; other site
996285001373	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
996285001374	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
996285001375	dimer interface [polypeptide binding]; other site
996285001376	ADP-ribose binding site [chemical binding]; other site
996285001377	active site
996285001378	nudix motif; other site
996285001379	metal binding site [ion binding]; metal-binding site
996285001380	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996285001381	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
996285001382	active site
996285001383	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
996285001384	Flagellin N-methylase; Region: FliB; pfam03692
996285001385	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
996285001386	homodimer interface [polypeptide binding]; other site
996285001387	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
996285001388	active site pocket [active]
996285001389	fructose-1,6-bisphosphatase family protein; Region: PLN02628
996285001390	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
996285001391	AMP binding site [chemical binding]; other site
996285001392	metal binding site [ion binding]; metal-binding site
996285001393	active site
996285001394	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
996285001395	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
996285001396	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
996285001397	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
996285001398	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
996285001399	TAP-like protein; Region: Abhydrolase_4; pfam08386
996285001400	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
996285001401	putative active site [active]
996285001402	dimerization interface [polypeptide binding]; other site
996285001403	putative tRNAtyr binding site [nucleotide binding]; other site
996285001404	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
996285001405	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
996285001406	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
996285001407	sec-independent translocase; Provisional; Region: tatB; PRK00404
996285001408	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
996285001409	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
996285001410	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
996285001411	metal binding site [ion binding]; metal-binding site
996285001412	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
996285001413	ABC1 family; Region: ABC1; cl17513
996285001414	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
996285001415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
996285001416	SCP-2 sterol transfer family; Region: SCP2; pfam02036
996285001417	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
996285001418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285001419	S-adenosylmethionine binding site [chemical binding]; other site
996285001420	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
996285001421	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285001422	dimerization interface [polypeptide binding]; other site
996285001423	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285001424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285001425	dimer interface [polypeptide binding]; other site
996285001426	putative CheW interface [polypeptide binding]; other site
996285001427	Protein of unknown function (DUF971); Region: DUF971; pfam06155
996285001428	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
996285001429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285001430	Walker A motif; other site
996285001431	ATP binding site [chemical binding]; other site
996285001432	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
996285001433	Walker B motif; other site
996285001434	arginine finger; other site
996285001435	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
996285001436	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
996285001437	active site
996285001438	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
996285001439	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
996285001440	putative molybdopterin cofactor binding site [chemical binding]; other site
996285001441	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
996285001442	putative molybdopterin cofactor binding site; other site
996285001443	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
996285001444	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
996285001445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001446	active site
996285001447	phosphorylation site [posttranslational modification]
996285001448	intermolecular recognition site; other site
996285001449	dimerization interface [polypeptide binding]; other site
996285001450	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285001451	Walker A motif; other site
996285001452	ATP binding site [chemical binding]; other site
996285001453	Walker B motif; other site
996285001454	arginine finger; other site
996285001455	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285001456	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
996285001457	PAS domain; Region: PAS; smart00091
996285001458	putative active site [active]
996285001459	heme pocket [chemical binding]; other site
996285001460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285001461	dimer interface [polypeptide binding]; other site
996285001462	phosphorylation site [posttranslational modification]
996285001463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001464	ATP binding site [chemical binding]; other site
996285001465	Mg2+ binding site [ion binding]; other site
996285001466	G-X-G motif; other site
996285001467	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285001468	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285001469	glutamine synthetase; Provisional; Region: glnA; PRK09469
996285001470	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
996285001471	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
996285001472	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
996285001473	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
996285001474	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
996285001475	Ligand Binding Site [chemical binding]; other site
996285001476	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
996285001477	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
996285001478	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
996285001479	G1 box; other site
996285001480	putative GEF interaction site [polypeptide binding]; other site
996285001481	GTP/Mg2+ binding site [chemical binding]; other site
996285001482	Switch I region; other site
996285001483	G2 box; other site
996285001484	G3 box; other site
996285001485	Switch II region; other site
996285001486	G4 box; other site
996285001487	G5 box; other site
996285001488	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
996285001489	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
996285001490	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285001491	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285001492	dimer interface [polypeptide binding]; other site
996285001493	putative CheW interface [polypeptide binding]; other site
996285001494	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
996285001495	sensory histidine kinase DcuS; Provisional; Region: PRK11086
996285001496	PAS domain; Region: PAS; smart00091
996285001497	putative active site [active]
996285001498	heme pocket [chemical binding]; other site
996285001499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001500	ATP binding site [chemical binding]; other site
996285001501	Mg2+ binding site [ion binding]; other site
996285001502	G-X-G motif; other site
996285001503	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
996285001504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001505	active site
996285001506	phosphorylation site [posttranslational modification]
996285001507	intermolecular recognition site; other site
996285001508	dimerization interface [polypeptide binding]; other site
996285001509	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
996285001510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996285001511	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
996285001512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285001513	dimerization interface [polypeptide binding]; other site
996285001514	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285001515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285001516	phosphorylation site [posttranslational modification]
996285001517	dimer interface [polypeptide binding]; other site
996285001518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001519	ATP binding site [chemical binding]; other site
996285001520	Mg2+ binding site [ion binding]; other site
996285001521	G-X-G motif; other site
996285001522	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285001523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001524	active site
996285001525	phosphorylation site [posttranslational modification]
996285001526	intermolecular recognition site; other site
996285001527	dimerization interface [polypeptide binding]; other site
996285001528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285001529	Walker A motif; other site
996285001530	ATP binding site [chemical binding]; other site
996285001531	Walker B motif; other site
996285001532	arginine finger; other site
996285001533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
996285001534	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
996285001535	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
996285001536	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
996285001537	Cytochrome c; Region: Cytochrom_C; cl11414
996285001538	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
996285001539	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285001540	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285001541	metal binding site [ion binding]; metal-binding site
996285001542	active site
996285001543	I-site; other site
996285001544	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285001545	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
996285001546	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
996285001547	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285001548	active site
996285001549	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
996285001550	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
996285001551	short chain dehydrogenase; Provisional; Region: PRK06181
996285001552	putative NAD(P) binding site [chemical binding]; other site
996285001553	active site
996285001554	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
996285001555	DTAP/Switch II; other site
996285001556	Switch I; other site
996285001557	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
996285001558	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
996285001559	Carbon starvation protein CstA; Region: CstA; pfam02554
996285001560	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
996285001561	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
996285001562	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
996285001563	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
996285001564	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996285001565	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
996285001566	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
996285001567	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
996285001568	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996285001569	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
996285001570	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996285001571	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
996285001572	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
996285001573	dimer interface [polypeptide binding]; other site
996285001574	phosphorylation site [posttranslational modification]
996285001575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001576	ATP binding site [chemical binding]; other site
996285001577	Mg2+ binding site [ion binding]; other site
996285001578	G-X-G motif; other site
996285001579	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
996285001580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001581	active site
996285001582	phosphorylation site [posttranslational modification]
996285001583	intermolecular recognition site; other site
996285001584	dimerization interface [polypeptide binding]; other site
996285001585	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285001586	DNA binding site [nucleotide binding]
996285001587	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
996285001588	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285001589	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285001590	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285001591	Curlin associated repeat; Region: Curlin_rpt; pfam07012
996285001592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285001593	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285001594	DNA binding residues [nucleotide binding]
996285001595	dimerization interface [polypeptide binding]; other site
996285001596	OPT oligopeptide transporter protein; Region: OPT; cl14607
996285001597	OPT oligopeptide transporter protein; Region: OPT; cl14607
996285001598	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
996285001599	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
996285001600	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
996285001601	ligand binding site [chemical binding]; other site
996285001602	NAD binding site [chemical binding]; other site
996285001603	tetramer interface [polypeptide binding]; other site
996285001604	catalytic site [active]
996285001605	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
996285001606	L-serine binding site [chemical binding]; other site
996285001607	ACT domain interface; other site
996285001608	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
996285001609	FAD binding domain; Region: FAD_binding_4; pfam01565
996285001610	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
996285001611	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
996285001612	SdiA-regulated; Region: SdiA-regulated; pfam06977
996285001613	SdiA-regulated; Region: SdiA-regulated; cd09971
996285001614	putative active site [active]
996285001615	SdiA-regulated; Region: SdiA-regulated; pfam06977
996285001616	SdiA-regulated; Region: SdiA-regulated; cd09971
996285001617	putative active site [active]
996285001618	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
996285001619	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
996285001620	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
996285001621	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996285001622	active site
996285001623	dimer interface [polypeptide binding]; other site
996285001624	threonine dehydratase; Reviewed; Region: PRK09224
996285001625	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
996285001626	tetramer interface [polypeptide binding]; other site
996285001627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285001628	catalytic residue [active]
996285001629	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
996285001630	putative Ile/Val binding site [chemical binding]; other site
996285001631	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
996285001632	putative Ile/Val binding site [chemical binding]; other site
996285001633	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
996285001634	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
996285001635	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
996285001636	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
996285001637	putative active site [active]
996285001638	Ap4A binding site [chemical binding]; other site
996285001639	nudix motif; other site
996285001640	putative metal binding site [ion binding]; other site
996285001641	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
996285001642	GAF domain; Region: GAF; pfam01590
996285001643	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
996285001644	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
996285001645	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
996285001646	NRDE protein; Region: NRDE; cl01315
996285001647	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996285001648	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
996285001649	thymidylate synthase; Reviewed; Region: thyA; PRK01827
996285001650	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
996285001651	dimerization interface [polypeptide binding]; other site
996285001652	active site
996285001653	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
996285001654	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285001655	P-loop; other site
996285001656	Magnesium ion binding site [ion binding]; other site
996285001657	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285001658	Magnesium ion binding site [ion binding]; other site
996285001659	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
996285001660	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285001661	TM-ABC transporter signature motif; other site
996285001662	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285001663	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
996285001664	TM-ABC transporter signature motif; other site
996285001665	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
996285001666	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
996285001667	Walker A/P-loop; other site
996285001668	ATP binding site [chemical binding]; other site
996285001669	Q-loop/lid; other site
996285001670	ABC transporter signature motif; other site
996285001671	Walker B; other site
996285001672	D-loop; other site
996285001673	H-loop/switch region; other site
996285001674	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
996285001675	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
996285001676	Walker A/P-loop; other site
996285001677	ATP binding site [chemical binding]; other site
996285001678	Q-loop/lid; other site
996285001679	ABC transporter signature motif; other site
996285001680	Walker B; other site
996285001681	D-loop; other site
996285001682	H-loop/switch region; other site
996285001683	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
996285001684	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
996285001685	putative ligand binding site [chemical binding]; other site
996285001686	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285001687	Ligand Binding Site [chemical binding]; other site
996285001688	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285001689	Ligand Binding Site [chemical binding]; other site
996285001690	Response regulator receiver domain; Region: Response_reg; pfam00072
996285001691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001692	active site
996285001693	phosphorylation site [posttranslational modification]
996285001694	intermolecular recognition site; other site
996285001695	dimerization interface [polypeptide binding]; other site
996285001696	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285001697	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
996285001698	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285001699	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
996285001700	Domain of unknown function DUF21; Region: DUF21; pfam01595
996285001701	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
996285001702	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
996285001703	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
996285001704	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996285001705	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285001706	putative active site [active]
996285001707	heme pocket [chemical binding]; other site
996285001708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285001709	dimer interface [polypeptide binding]; other site
996285001710	phosphorylation site [posttranslational modification]
996285001711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285001712	ATP binding site [chemical binding]; other site
996285001713	Mg2+ binding site [ion binding]; other site
996285001714	G-X-G motif; other site
996285001715	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
996285001716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001717	active site
996285001718	phosphorylation site [posttranslational modification]
996285001719	intermolecular recognition site; other site
996285001720	dimerization interface [polypeptide binding]; other site
996285001721	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285001722	DNA binding site [nucleotide binding]
996285001723	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
996285001724	UbiA prenyltransferase family; Region: UbiA; pfam01040
996285001725	Chorismate lyase; Region: Chor_lyase; cl01230
996285001726	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
996285001727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285001728	DNA-binding site [nucleotide binding]; DNA binding site
996285001729	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
996285001730	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
996285001731	FAD binding domain; Region: FAD_binding_4; pfam01565
996285001732	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
996285001733	FAD binding domain; Region: FAD_binding_4; pfam01565
996285001734	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
996285001735	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285001736	Cysteine-rich domain; Region: CCG; pfam02754
996285001737	Cysteine-rich domain; Region: CCG; pfam02754
996285001738	Domain of unknown function (DUF336); Region: DUF336; cl01249
996285001739	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
996285001740	active site
996285001741	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
996285001742	L-lactate permease; Region: Lactate_perm; cl00701
996285001743	Rubredoxin [Energy production and conversion]; Region: COG1773
996285001744	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
996285001745	iron binding site [ion binding]; other site
996285001746	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
996285001747	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285001748	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
996285001749	IHF dimer interface [polypeptide binding]; other site
996285001750	IHF - DNA interface [nucleotide binding]; other site
996285001751	SCP-2 sterol transfer family; Region: SCP2; cl01225
996285001752	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
996285001753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285001754	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
996285001755	dimerization interface [polypeptide binding]; other site
996285001756	substrate binding pocket [chemical binding]; other site
996285001757	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
996285001758	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285001759	FAD binding site [chemical binding]; other site
996285001760	substrate binding pocket [chemical binding]; other site
996285001761	catalytic base [active]
996285001762	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
996285001763	CoA-transferase family III; Region: CoA_transf_3; pfam02515
996285001764	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
996285001765	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
996285001766	putative NAD(P) binding site [chemical binding]; other site
996285001767	dimer interface [polypeptide binding]; other site
996285001768	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285001769	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285001770	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285001771	putative effector binding pocket; other site
996285001772	dimerization interface [polypeptide binding]; other site
996285001773	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
996285001774	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
996285001775	Repair protein; Region: Repair_PSII; pfam04536
996285001776	Repair protein; Region: Repair_PSII; cl01535
996285001777	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
996285001778	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
996285001779	conserved cys residue [active]
996285001780	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285001781	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285001782	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
996285001783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285001784	Walker A motif; other site
996285001785	ATP binding site [chemical binding]; other site
996285001786	Walker B motif; other site
996285001787	arginine finger; other site
996285001788	Peptidase family M41; Region: Peptidase_M41; pfam01434
996285001789	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
996285001790	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285001791	substrate binding pocket [chemical binding]; other site
996285001792	membrane-bound complex binding site; other site
996285001793	hinge residues; other site
996285001794	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285001795	Cytochrome c; Region: Cytochrom_C; pfam00034
996285001796	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
996285001797	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
996285001798	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
996285001799	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
996285001800	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
996285001801	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
996285001802	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285001803	catalytic loop [active]
996285001804	iron binding site [ion binding]; other site
996285001805	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
996285001806	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285001807	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285001808	ligand binding site [chemical binding]; other site
996285001809	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
996285001810	homotrimer interaction site [polypeptide binding]; other site
996285001811	putative active site [active]
996285001812	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
996285001813	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996285001814	Zn2+ binding site [ion binding]; other site
996285001815	Mg2+ binding site [ion binding]; other site
996285001816	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
996285001817	synthetase active site [active]
996285001818	NTP binding site [chemical binding]; other site
996285001819	metal binding site [ion binding]; metal-binding site
996285001820	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
996285001821	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
996285001822	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
996285001823	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
996285001824	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
996285001825	catalytic site [active]
996285001826	G-X2-G-X-G-K; other site
996285001827	hypothetical protein; Provisional; Region: PRK11820
996285001828	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
996285001829	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
996285001830	ribonuclease PH; Reviewed; Region: rph; PRK00173
996285001831	Ribonuclease PH; Region: RNase_PH_bact; cd11362
996285001832	hexamer interface [polypeptide binding]; other site
996285001833	active site
996285001834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
996285001835	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
996285001836	putative active site [active]
996285001837	putative catalytic site [active]
996285001838	putative DNA binding site [nucleotide binding]; other site
996285001839	putative phosphate binding site [ion binding]; other site
996285001840	metal binding site A [ion binding]; metal-binding site
996285001841	putative AP binding site [nucleotide binding]; other site
996285001842	putative metal binding site B [ion binding]; other site
996285001843	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285001844	active site
996285001845	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285001846	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
996285001847	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
996285001848	feedback inhibition sensing region; other site
996285001849	homohexameric interface [polypeptide binding]; other site
996285001850	nucleotide binding site [chemical binding]; other site
996285001851	N-acetyl-L-glutamate binding site [chemical binding]; other site
996285001852	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
996285001853	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
996285001854	active site
996285001855	substrate binding site [chemical binding]; other site
996285001856	metal binding site [ion binding]; metal-binding site
996285001857	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
996285001858	trimer interface [polypeptide binding]; other site
996285001859	active site
996285001860	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
996285001861	Flavoprotein; Region: Flavoprotein; pfam02441
996285001862	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
996285001863	hypothetical protein; Reviewed; Region: PRK00024
996285001864	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
996285001865	MPN+ (JAMM) motif; other site
996285001866	Zinc-binding site [ion binding]; other site
996285001867	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996285001868	CoenzymeA binding site [chemical binding]; other site
996285001869	subunit interaction site [polypeptide binding]; other site
996285001870	PHB binding site; other site
996285001871	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
996285001872	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
996285001873	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285001874	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285001875	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285001876	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285001877	dimer interface [polypeptide binding]; other site
996285001878	putative CheW interface [polypeptide binding]; other site
996285001879	Protein of unknown function (DUF962); Region: DUF962; cl01879
996285001880	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
996285001881	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
996285001882	putative active site [active]
996285001883	catalytic site [active]
996285001884	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
996285001885	putative active site [active]
996285001886	catalytic site [active]
996285001887	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
996285001888	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
996285001889	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285001890	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285001891	putative DNA binding site [nucleotide binding]; other site
996285001892	putative Zn2+ binding site [ion binding]; other site
996285001893	AsnC family; Region: AsnC_trans_reg; pfam01037
996285001894	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
996285001895	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
996285001896	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
996285001897	homotrimer interaction site [polypeptide binding]; other site
996285001898	putative active site [active]
996285001899	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
996285001900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285001901	non-specific DNA binding site [nucleotide binding]; other site
996285001902	salt bridge; other site
996285001903	sequence-specific DNA binding site [nucleotide binding]; other site
996285001904	Cupin domain; Region: Cupin_2; pfam07883
996285001905	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
996285001906	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
996285001907	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285001908	active site
996285001909	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
996285001910	trehalose synthase; Region: treS_nterm; TIGR02456
996285001911	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
996285001912	active site
996285001913	catalytic site [active]
996285001914	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
996285001915	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
996285001916	active site
996285001917	catalytic site [active]
996285001918	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
996285001919	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
996285001920	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
996285001921	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
996285001922	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
996285001923	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
996285001924	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
996285001925	putative active site [active]
996285001926	metal binding site [ion binding]; metal-binding site
996285001927	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
996285001928	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
996285001929	tetrameric interface [polypeptide binding]; other site
996285001930	NAD binding site [chemical binding]; other site
996285001931	catalytic residues [active]
996285001932	Transcriptional regulator [Transcription]; Region: IclR; COG1414
996285001933	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
996285001934	Bacterial transcriptional regulator; Region: IclR; pfam01614
996285001935	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
996285001936	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
996285001937	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
996285001938	Part of AAA domain; Region: AAA_19; pfam13245
996285001939	Family description; Region: UvrD_C_2; pfam13538
996285001940	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285001941	metal binding site [ion binding]; metal-binding site
996285001942	active site
996285001943	I-site; other site
996285001944	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285001945	BCCT family transporter; Region: BCCT; cl00569
996285001946	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
996285001947	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
996285001948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285001949	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
996285001950	Walker A motif; other site
996285001951	ATP binding site [chemical binding]; other site
996285001952	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
996285001953	Membrane fusogenic activity; Region: BMFP; pfam04380
996285001954	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
996285001955	Nitrogen regulatory protein P-II; Region: P-II; smart00938
996285001956	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
996285001957	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
996285001958	Uncharacterized conserved protein [Function unknown]; Region: COG0432
996285001959	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
996285001960	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285001961	motif II; other site
996285001962	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
996285001963	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285001964	active site
996285001965	DNA binding site [nucleotide binding]
996285001966	Int/Topo IB signature motif; other site
996285001967	Protein of unknown function, DUF484; Region: DUF484; pfam04340
996285001968	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
996285001969	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
996285001970	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
996285001971	diaminopimelate decarboxylase; Region: lysA; TIGR01048
996285001972	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
996285001973	active site
996285001974	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996285001975	substrate binding site [chemical binding]; other site
996285001976	catalytic residues [active]
996285001977	dimer interface [polypeptide binding]; other site
996285001978	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
996285001979	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
996285001980	putative iron binding site [ion binding]; other site
996285001981	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
996285001982	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
996285001983	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285001984	DNA binding residues [nucleotide binding]
996285001985	adenylate cyclase; Provisional; Region: cyaA; PRK09450
996285001986	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
996285001987	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
996285001988	TIGR02647 family protein; Region: DNA
996285001989	NnrS protein; Region: NnrS; pfam05940
996285001990	argininosuccinate lyase; Provisional; Region: PRK00855
996285001991	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
996285001992	active sites [active]
996285001993	tetramer interface [polypeptide binding]; other site
996285001994	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
996285001995	Histidine kinase; Region: His_kinase; pfam06580
996285001996	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
996285001997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285001998	active site
996285001999	phosphorylation site [posttranslational modification]
996285002000	intermolecular recognition site; other site
996285002001	dimerization interface [polypeptide binding]; other site
996285002002	LytTr DNA-binding domain; Region: LytTR; pfam04397
996285002003	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
996285002004	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
996285002005	domain interfaces; other site
996285002006	active site
996285002007	uroporphyrinogen-III synthase; Validated; Region: PRK05752
996285002008	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
996285002009	active site
996285002010	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
996285002011	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
996285002012	HemY protein N-terminus; Region: HemY_N; pfam07219
996285002013	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
996285002014	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
996285002015	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
996285002016	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
996285002017	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
996285002018	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285002019	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285002020	ABC transporter; Region: ABC_tran_2; pfam12848
996285002021	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285002022	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996285002023	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285002024	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
996285002025	LysE type translocator; Region: LysE; cl00565
996285002026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
996285002027	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
996285002028	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
996285002029	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
996285002030	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285002031	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285002032	metal binding site [ion binding]; metal-binding site
996285002033	active site
996285002034	I-site; other site
996285002035	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285002036	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996285002037	CoenzymeA binding site [chemical binding]; other site
996285002038	subunit interaction site [polypeptide binding]; other site
996285002039	PHB binding site; other site
996285002040	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
996285002041	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
996285002042	conserved cys residue [active]
996285002043	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
996285002044	dimer interface [polypeptide binding]; other site
996285002045	allosteric magnesium binding site [ion binding]; other site
996285002046	active site
996285002047	aspartate-rich active site metal binding site; other site
996285002048	Schiff base residues; other site
996285002049	polyphosphate kinase; Provisional; Region: PRK05443
996285002050	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
996285002051	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
996285002052	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
996285002053	putative active site [active]
996285002054	catalytic site [active]
996285002055	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
996285002056	putative domain interface [polypeptide binding]; other site
996285002057	putative active site [active]
996285002058	catalytic site [active]
996285002059	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
996285002060	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
996285002061	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
996285002062	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996285002063	catalytic residues [active]
996285002064	transcription termination factor Rho; Provisional; Region: rho; PRK09376
996285002065	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
996285002066	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
996285002067	RNA binding site [nucleotide binding]; other site
996285002068	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
996285002069	multimer interface [polypeptide binding]; other site
996285002070	Walker A motif; other site
996285002071	ATP binding site [chemical binding]; other site
996285002072	Walker B motif; other site
996285002073	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
996285002074	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
996285002075	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285002076	catalytic loop [active]
996285002077	iron binding site [ion binding]; other site
996285002078	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
996285002079	FAD binding pocket [chemical binding]; other site
996285002080	FAD binding motif [chemical binding]; other site
996285002081	phosphate binding motif [ion binding]; other site
996285002082	beta-alpha-beta structure motif; other site
996285002083	NAD binding pocket [chemical binding]; other site
996285002084	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
996285002085	Sporulation related domain; Region: SPOR; pfam05036
996285002086	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
996285002087	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
996285002088	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
996285002089	active site
996285002090	HIGH motif; other site
996285002091	KMSK motif region; other site
996285002092	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
996285002093	tRNA binding surface [nucleotide binding]; other site
996285002094	anticodon binding site; other site
996285002095	primosome assembly protein PriA; Validated; Region: PRK05580
996285002096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285002097	ATP binding site [chemical binding]; other site
996285002098	putative Mg++ binding site [ion binding]; other site
996285002099	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
996285002100	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
996285002101	ATP-binding site [chemical binding]; other site
996285002102	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
996285002103	Staphylococcal nuclease homologues; Region: SNc; smart00318
996285002104	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
996285002105	Catalytic site; other site
996285002106	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
996285002107	Malic enzyme, N-terminal domain; Region: malic; pfam00390
996285002108	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
996285002109	putative NAD(P) binding site [chemical binding]; other site
996285002110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285002111	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285002112	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
996285002113	Transglycosylase; Region: Transgly; pfam00912
996285002114	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
996285002115	Competence protein A; Region: Competence_A; pfam11104
996285002116	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
996285002117	nucleotide binding site [chemical binding]; other site
996285002118	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
996285002119	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
996285002120	Pilus assembly protein, PilO; Region: PilO; cl01234
996285002121	Pilus assembly protein, PilP; Region: PilP; pfam04351
996285002122	AMIN domain; Region: AMIN; pfam11741
996285002123	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
996285002124	Secretin and TonB N terminus short domain; Region: STN; smart00965
996285002125	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
996285002126	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
996285002127	shikimate kinase; Reviewed; Region: aroK; PRK00131
996285002128	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
996285002129	ADP binding site [chemical binding]; other site
996285002130	magnesium binding site [ion binding]; other site
996285002131	putative shikimate binding site; other site
996285002132	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
996285002133	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
996285002134	active site
996285002135	dimer interface [polypeptide binding]; other site
996285002136	metal binding site [ion binding]; metal-binding site
996285002137	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
996285002138	Sporulation related domain; Region: SPOR; pfam05036
996285002139	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
996285002140	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
996285002141	active site
996285002142	dimer interface [polypeptide binding]; other site
996285002143	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
996285002144	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
996285002145	active site
996285002146	FMN binding site [chemical binding]; other site
996285002147	substrate binding site [chemical binding]; other site
996285002148	3Fe-4S cluster binding site [ion binding]; other site
996285002149	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
996285002150	domain interface; other site
996285002151	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
996285002152	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285002153	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285002154	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
996285002155	substrate binding site [chemical binding]; other site
996285002156	active site
996285002157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285002158	putative substrate translocation pore; other site
996285002159	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
996285002160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285002161	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
996285002162	dimerization interface [polypeptide binding]; other site
996285002163	substrate binding pocket [chemical binding]; other site
996285002164	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
996285002165	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996285002166	catalytic residues [active]
996285002167	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
996285002168	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
996285002169	homodimer interface [polypeptide binding]; other site
996285002170	substrate-cofactor binding pocket; other site
996285002171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285002172	catalytic residue [active]
996285002173	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
996285002174	transmembrane helices; other site
996285002175	TrkA-C domain; Region: TrkA_C; pfam02080
996285002176	TrkA-C domain; Region: TrkA_C; pfam02080
996285002177	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
996285002178	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
996285002179	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285002180	active site
996285002181	DNA binding site [nucleotide binding]
996285002182	Int/Topo IB signature motif; other site
996285002183	TraX protein; Region: TraX; cl05434
996285002184	Transposase; Region: HTH_Tnp_1; pfam01527
996285002185	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
996285002186	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
996285002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285002188	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
996285002189	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285002190	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
996285002191	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
996285002192	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
996285002193	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996285002194	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
996285002195	TrwC relaxase; Region: TrwC; pfam08751
996285002196	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
996285002197	AAA domain; Region: AAA_30; pfam13604
996285002198	Family description; Region: UvrD_C_2; pfam13538
996285002199	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
996285002200	Toprim-like; Region: Toprim_2; pfam13155
996285002201	Transposase domain (DUF772); Region: DUF772; pfam05598
996285002202	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285002203	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285002204	AAA domain; Region: AAA_23; pfam13476
996285002205	P-loop containing region of AAA domain; Region: AAA_29; cl17516
996285002206	replicative DNA helicase; Provisional; Region: PRK05973
996285002207	TIGR04255 family protein; Region: sporadTIGR04255
996285002208	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
996285002209	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
996285002210	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
996285002211	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
996285002212	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285002213	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
996285002214	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285002215	DNA binding residues [nucleotide binding]
996285002216	DNA primase, catalytic core; Region: dnaG; TIGR01391
996285002217	CHC2 zinc finger; Region: zf-CHC2; pfam01807
996285002218	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
996285002219	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
996285002220	active site
996285002221	metal binding site [ion binding]; metal-binding site
996285002222	interdomain interaction site; other site
996285002223	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
996285002224	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
996285002225	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
996285002226	UGMP family protein; Validated; Region: PRK09604
996285002227	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
996285002228	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
996285002229	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
996285002230	homooctamer interface [polypeptide binding]; other site
996285002231	active site
996285002232	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
996285002233	catalytic center binding site [active]
996285002234	ATP binding site [chemical binding]; other site
996285002235	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
996285002236	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
996285002237	active site
996285002238	NTP binding site [chemical binding]; other site
996285002239	metal binding triad [ion binding]; metal-binding site
996285002240	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
996285002241	SpoVR family protein; Provisional; Region: PRK11767
996285002242	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
996285002243	hypothetical protein; Provisional; Region: PRK05325
996285002244	PrkA family serine protein kinase; Provisional; Region: PRK15455
996285002245	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
996285002246	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
996285002247	active site residue [active]
996285002248	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
996285002249	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
996285002250	active site
996285002251	metal binding site [ion binding]; metal-binding site
996285002252	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
996285002253	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
996285002254	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
996285002255	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
996285002256	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
996285002257	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
996285002258	SurA N-terminal domain; Region: SurA_N; pfam09312
996285002259	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
996285002260	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
996285002261	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
996285002262	OstA-like protein; Region: OstA; cl00844
996285002263	Organic solvent tolerance protein; Region: OstA_C; pfam04453
996285002264	Phosphotransferase enzyme family; Region: APH; pfam01636
996285002265	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
996285002266	active site
996285002267	ATP binding site [chemical binding]; other site
996285002268	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
996285002269	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
996285002270	Substrate binding site; other site
996285002271	metal-binding site
996285002272	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
996285002273	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
996285002274	putative metal binding site [ion binding]; other site
996285002275	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
996285002276	HSP70 interaction site [polypeptide binding]; other site
996285002277	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
996285002278	potential frameshift: common BLAST hit: gi|339492706|ref|YP_004712999.1| two-component sensor
996285002279	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285002280	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
996285002281	substrate binding pocket [chemical binding]; other site
996285002282	membrane-bound complex binding site; other site
996285002283	hinge residues; other site
996285002284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285002285	PAS fold; Region: PAS_3; pfam08447
996285002286	putative active site [active]
996285002287	heme pocket [chemical binding]; other site
996285002288	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996285002289	Histidine kinase; Region: HisKA_3; pfam07730
996285002290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285002291	ATP binding site [chemical binding]; other site
996285002292	Mg2+ binding site [ion binding]; other site
996285002293	G-X-G motif; other site
996285002294	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285002295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285002296	active site
996285002297	phosphorylation site [posttranslational modification]
996285002298	intermolecular recognition site; other site
996285002299	dimerization interface [polypeptide binding]; other site
996285002300	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285002301	DNA binding residues [nucleotide binding]
996285002302	dimerization interface [polypeptide binding]; other site
996285002303	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
996285002304	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
996285002305	Walker A/P-loop; other site
996285002306	ATP binding site [chemical binding]; other site
996285002307	Q-loop/lid; other site
996285002308	ABC transporter signature motif; other site
996285002309	Walker B; other site
996285002310	D-loop; other site
996285002311	H-loop/switch region; other site
996285002312	TOBE domain; Region: TOBE_2; pfam08402
996285002313	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
996285002314	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
996285002315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285002316	dimer interface [polypeptide binding]; other site
996285002317	conserved gate region; other site
996285002318	putative PBP binding loops; other site
996285002319	ABC-ATPase subunit interface; other site
996285002320	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
996285002321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285002322	dimer interface [polypeptide binding]; other site
996285002323	conserved gate region; other site
996285002324	putative PBP binding loops; other site
996285002325	ABC-ATPase subunit interface; other site
996285002326	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
996285002327	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
996285002328	tetramerization interface [polypeptide binding]; other site
996285002329	NAD(P) binding site [chemical binding]; other site
996285002330	catalytic residues [active]
996285002331	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
996285002332	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285002333	inhibitor-cofactor binding pocket; inhibition site
996285002334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285002335	catalytic residue [active]
996285002336	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
996285002337	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
996285002338	substrate binding site [chemical binding]; other site
996285002339	hexamer interface [polypeptide binding]; other site
996285002340	metal binding site [ion binding]; metal-binding site
996285002341	phosphoglycolate phosphatase; Provisional; Region: PRK13222
996285002342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285002343	motif II; other site
996285002344	anthranilate synthase component I; Provisional; Region: PRK13565
996285002345	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
996285002346	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
996285002347	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
996285002348	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
996285002349	glutamine binding [chemical binding]; other site
996285002350	catalytic triad [active]
996285002351	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
996285002352	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
996285002353	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
996285002354	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
996285002355	active site
996285002356	ribulose/triose binding site [chemical binding]; other site
996285002357	phosphate binding site [ion binding]; other site
996285002358	substrate (anthranilate) binding pocket [chemical binding]; other site
996285002359	product (indole) binding pocket [chemical binding]; other site
996285002360	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285002361	ligand binding site [chemical binding]; other site
996285002362	flexible hinge region; other site
996285002363	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
996285002364	putative switch regulator; other site
996285002365	non-specific DNA interactions [nucleotide binding]; other site
996285002366	DNA binding site [nucleotide binding]
996285002367	sequence specific DNA binding site [nucleotide binding]; other site
996285002368	putative cAMP binding site [chemical binding]; other site
996285002369	OsmC-like protein; Region: OsmC; cl00767
996285002370	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
996285002371	diiron binding motif [ion binding]; other site
996285002372	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
996285002373	nucleotide binding site/active site [active]
996285002374	HIT family signature motif; other site
996285002375	catalytic residue [active]
996285002376	Ycf46; Provisional; Region: ycf46; CHL00195
996285002377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285002378	Walker A motif; other site
996285002379	ATP binding site [chemical binding]; other site
996285002380	Walker B motif; other site
996285002381	arginine finger; other site
996285002382	Protein of unknown function (DUF805); Region: DUF805; pfam05656
996285002383	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
996285002384	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
996285002385	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
996285002386	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
996285002387	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
996285002388	putative peptidase; Provisional; Region: PRK11649
996285002389	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
996285002390	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285002391	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
996285002392	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
996285002393	active site
996285002394	HIGH motif; other site
996285002395	dimer interface [polypeptide binding]; other site
996285002396	KMSKS motif; other site
996285002397	Sporulation related domain; Region: SPOR; cl10051
996285002398	potential frameshift: common BLAST hit: gi|339492745|ref|YP_004713038.1| elongation factor Tu
996285002399	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
996285002400	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
996285002401	G1 box; other site
996285002402	GEF interaction site [polypeptide binding]; other site
996285002403	GTP/Mg2+ binding site [chemical binding]; other site
996285002404	Switch I region; other site
996285002405	G2 box; other site
996285002406	G3 box; other site
996285002407	Switch II region; other site
996285002408	G4 box; other site
996285002409	G5 box; other site
996285002410	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
996285002411	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
996285002412	Antibiotic Binding Site [chemical binding]; other site
996285002413	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
996285002414	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
996285002415	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
996285002416	putative homodimer interface [polypeptide binding]; other site
996285002417	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
996285002418	heterodimer interface [polypeptide binding]; other site
996285002419	homodimer interface [polypeptide binding]; other site
996285002420	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
996285002421	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
996285002422	23S rRNA interface [nucleotide binding]; other site
996285002423	L7/L12 interface [polypeptide binding]; other site
996285002424	putative thiostrepton binding site; other site
996285002425	L25 interface [polypeptide binding]; other site
996285002426	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
996285002427	mRNA/rRNA interface [nucleotide binding]; other site
996285002428	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
996285002429	23S rRNA interface [nucleotide binding]; other site
996285002430	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
996285002431	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
996285002432	core dimer interface [polypeptide binding]; other site
996285002433	peripheral dimer interface [polypeptide binding]; other site
996285002434	L10 interface [polypeptide binding]; other site
996285002435	L11 interface [polypeptide binding]; other site
996285002436	putative EF-Tu interaction site [polypeptide binding]; other site
996285002437	putative EF-G interaction site [polypeptide binding]; other site
996285002438	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
996285002439	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
996285002440	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
996285002441	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
996285002442	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
996285002443	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
996285002444	RPB3 interaction site [polypeptide binding]; other site
996285002445	RPB1 interaction site [polypeptide binding]; other site
996285002446	RPB11 interaction site [polypeptide binding]; other site
996285002447	RPB10 interaction site [polypeptide binding]; other site
996285002448	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
996285002449	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
996285002450	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
996285002451	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
996285002452	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
996285002453	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
996285002454	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
996285002455	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
996285002456	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
996285002457	DNA binding site [nucleotide binding]
996285002458	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
996285002459	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
996285002460	S17 interaction site [polypeptide binding]; other site
996285002461	S8 interaction site; other site
996285002462	16S rRNA interaction site [nucleotide binding]; other site
996285002463	streptomycin interaction site [chemical binding]; other site
996285002464	23S rRNA interaction site [nucleotide binding]; other site
996285002465	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
996285002466	30S ribosomal protein S7; Validated; Region: PRK05302
996285002467	elongation factor G; Reviewed; Region: PRK00007
996285002468	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
996285002469	G1 box; other site
996285002470	putative GEF interaction site [polypeptide binding]; other site
996285002471	GTP/Mg2+ binding site [chemical binding]; other site
996285002472	Switch I region; other site
996285002473	G2 box; other site
996285002474	G3 box; other site
996285002475	Switch II region; other site
996285002476	G4 box; other site
996285002477	G5 box; other site
996285002478	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
996285002479	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
996285002480	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
996285002482	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
996285002483	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
996285002484	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
996285002485	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
996285002486	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
996285002487	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
996285002488	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
996285002489	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
996285002490	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
996285002491	protein-rRNA interface [nucleotide binding]; other site
996285002492	putative translocon binding site; other site
996285002493	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
996285002494	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
996285002495	G-X-X-G motif; other site
996285002496	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
996285002497	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
996285002498	23S rRNA interface [nucleotide binding]; other site
996285002499	5S rRNA interface [nucleotide binding]; other site
996285002500	putative antibiotic binding site [chemical binding]; other site
996285002501	L25 interface [polypeptide binding]; other site
996285002502	L27 interface [polypeptide binding]; other site
996285002503	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
996285002504	23S rRNA interface [nucleotide binding]; other site
996285002505	putative translocon interaction site; other site
996285002506	signal recognition particle (SRP54) interaction site; other site
996285002507	L23 interface [polypeptide binding]; other site
996285002508	trigger factor interaction site; other site
996285002509	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
996285002510	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
996285002511	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
996285002512	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
996285002513	RNA binding site [nucleotide binding]; other site
996285002514	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
996285002515	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
996285002516	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
996285002517	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
996285002518	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
996285002519	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
996285002520	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
996285002521	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
996285002522	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
996285002523	5S rRNA interface [nucleotide binding]; other site
996285002524	23S rRNA interface [nucleotide binding]; other site
996285002525	L5 interface [polypeptide binding]; other site
996285002526	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
996285002527	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
996285002528	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
996285002529	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
996285002530	23S rRNA binding site [nucleotide binding]; other site
996285002531	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
996285002532	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
996285002533	SecY translocase; Region: SecY; pfam00344
996285002534	Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257
996285002535	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
996285002536	30S ribosomal protein S13; Region: bact_S13; TIGR03631
996285002537	30S ribosomal protein S11; Validated; Region: PRK05309
996285002538	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
996285002539	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
996285002540	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285002541	RNA binding surface [nucleotide binding]; other site
996285002542	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
996285002543	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
996285002544	alphaNTD homodimer interface [polypeptide binding]; other site
996285002545	alphaNTD - beta interaction site [polypeptide binding]; other site
996285002546	alphaNTD - beta' interaction site [polypeptide binding]; other site
996285002547	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
996285002548	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
996285002549	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
996285002550	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
996285002551	tetramer interface [polypeptide binding]; other site
996285002552	heme binding pocket [chemical binding]; other site
996285002553	NADPH binding site [chemical binding]; other site
996285002554	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
996285002555	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
996285002556	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
996285002557	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
996285002558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285002559	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285002560	putative substrate translocation pore; other site
996285002561	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
996285002562	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
996285002563	dimer interface [polypeptide binding]; other site
996285002564	ssDNA binding site [nucleotide binding]; other site
996285002565	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996285002566	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
996285002567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285002568	NAD(P) binding site [chemical binding]; other site
996285002569	active site
996285002570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285002571	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
996285002572	NAD(P) binding site [chemical binding]; other site
996285002573	active site
996285002574	OmpW family; Region: OmpW; cl17427
996285002575	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
996285002576	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
996285002577	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
996285002578	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
996285002579	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
996285002580	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
996285002581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285002582	binding surface
996285002583	TPR motif; other site
996285002584	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
996285002585	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
996285002586	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996285002587	FtsX-like permease family; Region: FtsX; pfam02687
996285002588	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996285002589	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
996285002590	Walker A/P-loop; other site
996285002591	ATP binding site [chemical binding]; other site
996285002592	Q-loop/lid; other site
996285002593	ABC transporter signature motif; other site
996285002594	Walker B; other site
996285002595	D-loop; other site
996285002596	H-loop/switch region; other site
996285002597	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
996285002598	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
996285002599	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
996285002600	putative inner membrane protein; Provisional; Region: PRK11099
996285002601	hypothetical protein; Provisional; Region: PRK11018
996285002602	CPxP  motif; other site
996285002603	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
996285002604	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
996285002605	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
996285002606	Predicted methyltransferase [General function prediction only]; Region: COG3897
996285002607	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
996285002608	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
996285002609	ATP cone domain; Region: ATP-cone; pfam03477
996285002610	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
996285002611	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
996285002612	catalytic motif [active]
996285002613	Zn binding site [ion binding]; other site
996285002614	RibD C-terminal domain; Region: RibD_C; cl17279
996285002615	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
996285002616	Lumazine binding domain; Region: Lum_binding; pfam00677
996285002617	Lumazine binding domain; Region: Lum_binding; pfam00677
996285002618	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
996285002619	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
996285002620	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
996285002621	dimerization interface [polypeptide binding]; other site
996285002622	active site
996285002623	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
996285002624	homopentamer interface [polypeptide binding]; other site
996285002625	active site
996285002626	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
996285002627	putative RNA binding site [nucleotide binding]; other site
996285002628	thiamine monophosphate kinase; Provisional; Region: PRK05731
996285002629	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
996285002630	ATP binding site [chemical binding]; other site
996285002631	dimerization interface [polypeptide binding]; other site
996285002632	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
996285002633	tetramer interfaces [polypeptide binding]; other site
996285002634	binuclear metal-binding site [ion binding]; other site
996285002635	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
996285002636	catalytic motif [active]
996285002637	Catalytic residue [active]
996285002638	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
996285002639	dimerization interface [polypeptide binding]; other site
996285002640	active site
996285002641	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
996285002642	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
996285002643	cobalamin binding residues [chemical binding]; other site
996285002644	putative BtuC binding residues; other site
996285002645	dimer interface [polypeptide binding]; other site
996285002646	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
996285002647	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285002648	N-terminal plug; other site
996285002649	ligand-binding site [chemical binding]; other site
996285002650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285002651	Walker A/P-loop; other site
996285002652	ATP binding site [chemical binding]; other site
996285002653	Q-loop/lid; other site
996285002654	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285002655	ABC transporter signature motif; other site
996285002656	Walker B; other site
996285002657	D-loop; other site
996285002658	H-loop/switch region; other site
996285002659	exonuclease subunit SbcD; Provisional; Region: PRK10966
996285002660	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
996285002661	active site
996285002662	metal binding site [ion binding]; metal-binding site
996285002663	DNA binding site [nucleotide binding]
996285002664	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
996285002665	WYL domain; Region: WYL; pfam13280
996285002666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285002667	ATP binding site [chemical binding]; other site
996285002668	Mg2+ binding site [ion binding]; other site
996285002669	G-X-G motif; other site
996285002670	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285002671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285002672	active site
996285002673	phosphorylation site [posttranslational modification]
996285002674	intermolecular recognition site; other site
996285002675	dimerization interface [polypeptide binding]; other site
996285002676	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285002677	DNA binding site [nucleotide binding]
996285002678	Predicted membrane protein [Function unknown]; Region: COG3212
996285002679	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
996285002680	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
996285002681	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
996285002682	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
996285002683	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
996285002684	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
996285002685	probable active site [active]
996285002686	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
996285002687	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974
996285002688	putative DNA binding site [nucleotide binding]; other site
996285002689	catalytic residue [active]
996285002690	putative H2TH interface [polypeptide binding]; other site
996285002691	putative catalytic residues [active]
996285002692	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
996285002693	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
996285002694	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
996285002695	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285002696	active site
996285002697	thymidine phosphorylase; Provisional; Region: PRK04350
996285002698	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
996285002699	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
996285002700	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
996285002701	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
996285002702	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
996285002703	NAD binding site [chemical binding]; other site
996285002704	homotetramer interface [polypeptide binding]; other site
996285002705	homodimer interface [polypeptide binding]; other site
996285002706	substrate binding site [chemical binding]; other site
996285002707	active site
996285002708	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
996285002709	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
996285002710	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
996285002711	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285002712	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285002713	putative DNA binding site [nucleotide binding]; other site
996285002714	putative Zn2+ binding site [ion binding]; other site
996285002715	AsnC family; Region: AsnC_trans_reg; pfam01037
996285002716	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
996285002717	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
996285002718	dimer interface [polypeptide binding]; other site
996285002719	PYR/PP interface [polypeptide binding]; other site
996285002720	TPP binding site [chemical binding]; other site
996285002721	substrate binding site [chemical binding]; other site
996285002722	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
996285002723	TPP-binding site; other site
996285002724	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
996285002725	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
996285002726	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
996285002727	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
996285002728	NAD binding site [chemical binding]; other site
996285002729	Phe binding site; other site
996285002730	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
996285002731	Na2 binding site [ion binding]; other site
996285002732	putative substrate binding site 1 [chemical binding]; other site
996285002733	Na binding site 1 [ion binding]; other site
996285002734	putative substrate binding site 2 [chemical binding]; other site
996285002735	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
996285002736	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
996285002737	dimer interface [polypeptide binding]; other site
996285002738	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
996285002739	active site
996285002740	Fe binding site [ion binding]; other site
996285002741	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
996285002742	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
996285002743	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
996285002744	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
996285002745	maleylacetoacetate isomerase; Region: maiA; TIGR01262
996285002746	C-terminal domain interface [polypeptide binding]; other site
996285002747	GSH binding site (G-site) [chemical binding]; other site
996285002748	putative dimer interface [polypeptide binding]; other site
996285002749	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
996285002750	dimer interface [polypeptide binding]; other site
996285002751	N-terminal domain interface [polypeptide binding]; other site
996285002752	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
996285002753	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
996285002754	Na2 binding site [ion binding]; other site
996285002755	putative substrate binding site 1 [chemical binding]; other site
996285002756	Na binding site 1 [ion binding]; other site
996285002757	putative substrate binding site 2 [chemical binding]; other site
996285002758	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
996285002759	Cache domain; Region: Cache_1; pfam02743
996285002760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285002761	dimerization interface [polypeptide binding]; other site
996285002762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285002763	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285002764	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285002765	dimer interface [polypeptide binding]; other site
996285002766	putative CheW interface [polypeptide binding]; other site
996285002767	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285002768	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285002769	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
996285002770	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
996285002771	potential catalytic triad [active]
996285002772	conserved cys residue [active]
996285002773	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285002774	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
996285002775	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
996285002776	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
996285002777	TrkA-N domain; Region: TrkA_N; pfam02254
996285002778	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996285002779	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996285002780	ATP binding site [chemical binding]; other site
996285002781	Mg++ binding site [ion binding]; other site
996285002782	motif III; other site
996285002783	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285002784	nucleotide binding region [chemical binding]; other site
996285002785	ATP-binding site [chemical binding]; other site
996285002786	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285002787	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
996285002788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285002789	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285002790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285002791	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
996285002792	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
996285002793	NAD binding site [chemical binding]; other site
996285002794	substrate binding site [chemical binding]; other site
996285002795	catalytic Zn binding site [ion binding]; other site
996285002796	tetramer interface [polypeptide binding]; other site
996285002797	structural Zn binding site [ion binding]; other site
996285002798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285002799	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
996285002800	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
996285002801	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
996285002802	putative active site [active]
996285002803	Zn binding site [ion binding]; other site
996285002804	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
996285002805	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
996285002806	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
996285002807	active site
996285002808	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
996285002809	catalytic triad [active]
996285002810	dimer interface [polypeptide binding]; other site
996285002811	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
996285002812	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285002813	active site
996285002814	motif I; other site
996285002815	motif II; other site
996285002816	Predicted metalloprotease [General function prediction only]; Region: COG2321
996285002817	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
996285002818	Predicted metal-binding protein [General function prediction only]; Region: COG3019
996285002819	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
996285002820	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285002821	ligand binding site [chemical binding]; other site
996285002822	flexible hinge region; other site
996285002823	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
996285002824	putative switch regulator; other site
996285002825	non-specific DNA interactions [nucleotide binding]; other site
996285002826	DNA binding site [nucleotide binding]
996285002827	sequence specific DNA binding site [nucleotide binding]; other site
996285002828	putative cAMP binding site [chemical binding]; other site
996285002829	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
996285002830	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
996285002831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285002832	active site
996285002833	phosphorylation site [posttranslational modification]
996285002834	intermolecular recognition site; other site
996285002835	dimerization interface [polypeptide binding]; other site
996285002836	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285002837	DNA binding residues [nucleotide binding]
996285002838	dimerization interface [polypeptide binding]; other site
996285002839	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
996285002840	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
996285002841	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285002842	dimerization interface [polypeptide binding]; other site
996285002843	Histidine kinase; Region: HisKA_3; pfam07730
996285002844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285002845	ATP binding site [chemical binding]; other site
996285002846	Mg2+ binding site [ion binding]; other site
996285002847	G-X-G motif; other site
996285002848	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
996285002849	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
996285002850	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285002851	Ligand Binding Site [chemical binding]; other site
996285002852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285002853	putative substrate translocation pore; other site
996285002854	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285002855	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
996285002856	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
996285002857	[4Fe-4S] binding site [ion binding]; other site
996285002858	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285002859	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285002860	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285002861	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
996285002862	molybdopterin cofactor binding site; other site
996285002863	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
996285002864	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
996285002865	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
996285002866	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
996285002867	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
996285002868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285002869	FeS/SAM binding site; other site
996285002870	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
996285002871	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
996285002872	MPT binding site; other site
996285002873	trimer interface [polypeptide binding]; other site
996285002874	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
996285002875	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
996285002876	dimer interface [polypeptide binding]; other site
996285002877	putative functional site; other site
996285002878	putative MPT binding site; other site
996285002879	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
996285002880	sensor protein QseC; Provisional; Region: PRK10337
996285002881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285002882	dimer interface [polypeptide binding]; other site
996285002883	phosphorylation site [posttranslational modification]
996285002884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285002885	ATP binding site [chemical binding]; other site
996285002886	Mg2+ binding site [ion binding]; other site
996285002887	G-X-G motif; other site
996285002888	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285002889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285002890	active site
996285002891	phosphorylation site [posttranslational modification]
996285002892	intermolecular recognition site; other site
996285002893	dimerization interface [polypeptide binding]; other site
996285002894	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285002895	DNA binding site [nucleotide binding]
996285002896	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285002897	TPR motif; other site
996285002898	binding surface
996285002899	short chain dehydrogenase; Provisional; Region: PRK09072
996285002900	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285002901	NAD(P) binding site [chemical binding]; other site
996285002902	active site
996285002903	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
996285002904	heme binding pocket [chemical binding]; other site
996285002905	heme ligand [chemical binding]; other site
996285002906	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
996285002907	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
996285002908	acyl-activating enzyme (AAE) consensus motif; other site
996285002909	putative AMP binding site [chemical binding]; other site
996285002910	putative active site [active]
996285002911	putative CoA binding site [chemical binding]; other site
996285002912	Thermostable hemolysin; Region: T_hemolysin; pfam12261
996285002913	SdiA-regulated; Region: SdiA-regulated; pfam06977
996285002914	SdiA-regulated; Region: SdiA-regulated; cd09971
996285002915	putative active site [active]
996285002916	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285002917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285002918	active site
996285002919	phosphorylation site [posttranslational modification]
996285002920	intermolecular recognition site; other site
996285002921	dimerization interface [polypeptide binding]; other site
996285002922	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285002923	DNA binding site [nucleotide binding]
996285002924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285002925	HAMP domain; Region: HAMP; pfam00672
996285002926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285002927	dimer interface [polypeptide binding]; other site
996285002928	phosphorylation site [posttranslational modification]
996285002929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285002930	ATP binding site [chemical binding]; other site
996285002931	Mg2+ binding site [ion binding]; other site
996285002932	G-X-G motif; other site
996285002933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285002934	S-adenosylmethionine binding site [chemical binding]; other site
996285002935	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
996285002936	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
996285002937	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
996285002938	Sulfatase; Region: Sulfatase; pfam00884
996285002939	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
996285002940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285002941	S-adenosylmethionine binding site [chemical binding]; other site
996285002942	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
996285002943	DJ-1 family protein; Region: not_thiJ; TIGR01383
996285002944	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
996285002945	conserved cys residue [active]
996285002946	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
996285002947	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
996285002948	XdhC Rossmann domain; Region: XdhC_C; pfam13478
996285002949	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
996285002950	Ligand binding site; other site
996285002951	metal-binding site
996285002952	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
996285002953	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
996285002954	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
996285002955	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
996285002956	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
996285002957	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
996285002958	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
996285002959	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
996285002960	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
996285002961	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
996285002962	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
996285002963	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
996285002964	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
996285002965	DNA binding residues [nucleotide binding]
996285002966	putative dimer interface [polypeptide binding]; other site
996285002967	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
996285002968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285002969	S-adenosylmethionine binding site [chemical binding]; other site
996285002970	ferredoxin-NADP reductase; Provisional; Region: PRK10926
996285002971	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
996285002972	FAD binding pocket [chemical binding]; other site
996285002973	FAD binding motif [chemical binding]; other site
996285002974	phosphate binding motif [ion binding]; other site
996285002975	beta-alpha-beta structure motif; other site
996285002976	NAD binding pocket [chemical binding]; other site
996285002977	glutamate dehydrogenase; Provisional; Region: PRK09414
996285002978	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
996285002979	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
996285002980	NAD(P) binding site [chemical binding]; other site
996285002981	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285002982	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285002983	metal binding site [ion binding]; metal-binding site
996285002984	active site
996285002985	I-site; other site
996285002986	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
996285002987	Cache domain; Region: Cache_1; pfam02743
996285002988	HAMP domain; Region: HAMP; pfam00672
996285002989	dimerization interface [polypeptide binding]; other site
996285002990	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
996285002991	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
996285002992	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285002993	Walker A/P-loop; other site
996285002994	ATP binding site [chemical binding]; other site
996285002995	Q-loop/lid; other site
996285002996	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285002997	ABC transporter signature motif; other site
996285002998	Walker B; other site
996285002999	D-loop; other site
996285003000	ABC transporter; Region: ABC_tran_2; pfam12848
996285003001	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285003002	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
996285003003	active site
996285003004	catalytic residues [active]
996285003005	Int/Topo IB signature motif; other site
996285003006	DNA binding site [nucleotide binding]
996285003007	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
996285003008	active site
996285003009	Int/Topo IB signature motif; other site
996285003010	catalytic residues [active]
996285003011	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285003012	active site
996285003013	Int/Topo IB signature motif; other site
996285003014	High-affinity nickel-transport protein; Region: NicO; cl00964
996285003015	High-affinity nickel-transport protein; Region: NicO; cl00964
996285003016	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
996285003017	putative homodimer interface [polypeptide binding]; other site
996285003018	putative homotetramer interface [polypeptide binding]; other site
996285003019	putative metal binding site [ion binding]; other site
996285003020	putative homodimer-homodimer interface [polypeptide binding]; other site
996285003021	putative allosteric switch controlling residues; other site
996285003022	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
996285003023	AAA ATPase domain; Region: AAA_16; pfam13191
996285003024	AAA domain; Region: AAA_21; pfam13304
996285003025	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
996285003026	helicase superfamily c-terminal domain; Region: HELICc; smart00490
996285003027	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996285003028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285003029	salt bridge; other site
996285003030	non-specific DNA binding site [nucleotide binding]; other site
996285003031	sequence-specific DNA binding site [nucleotide binding]; other site
996285003032	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
996285003033	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
996285003034	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
996285003035	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
996285003036	HsdM N-terminal domain; Region: HsdM_N; pfam12161
996285003037	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
996285003038	Methyltransferase domain; Region: Methyltransf_26; pfam13659
996285003039	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
996285003040	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
996285003041	dimer interface [polypeptide binding]; other site
996285003042	active site
996285003043	glycine-pyridoxal phosphate binding site [chemical binding]; other site
996285003044	folate binding site [chemical binding]; other site
996285003045	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
996285003046	PilZ domain; Region: PilZ; pfam07238
996285003047	DNA repair protein RadA; Provisional; Region: PRK11823
996285003048	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
996285003049	Walker A motif/ATP binding site; other site
996285003050	ATP binding site [chemical binding]; other site
996285003051	Walker B motif; other site
996285003052	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
996285003053	Protein of unknown function (DUF465); Region: DUF465; cl01070
996285003054	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
996285003055	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
996285003056	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
996285003057	AAA domain; Region: AAA_32; pfam13654
996285003058	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
996285003059	hypothetical protein; Provisional; Region: PRK05208
996285003060	Transposase; Region: HTH_Tnp_1; pfam01527
996285003061	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
996285003062	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
996285003063	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285003064	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
996285003065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285003066	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
996285003067	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
996285003068	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
996285003069	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
996285003070	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
996285003071	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
996285003072	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
996285003073	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996285003074	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
996285003075	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
996285003076	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
996285003077	substrate binding pocket [chemical binding]; other site
996285003078	chain length determination region; other site
996285003079	substrate-Mg2+ binding site; other site
996285003080	catalytic residues [active]
996285003081	aspartate-rich region 1; other site
996285003082	active site lid residues [active]
996285003083	aspartate-rich region 2; other site
996285003084	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
996285003085	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
996285003086	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
996285003087	GTPase CgtA; Reviewed; Region: obgE; PRK12298
996285003088	GTP1/OBG; Region: GTP1_OBG; pfam01018
996285003089	Obg GTPase; Region: Obg; cd01898
996285003090	G1 box; other site
996285003091	GTP/Mg2+ binding site [chemical binding]; other site
996285003092	Switch I region; other site
996285003093	G2 box; other site
996285003094	G3 box; other site
996285003095	Switch II region; other site
996285003096	G4 box; other site
996285003097	G5 box; other site
996285003098	gamma-glutamyl kinase; Provisional; Region: PRK05429
996285003099	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
996285003100	nucleotide binding site [chemical binding]; other site
996285003101	homotetrameric interface [polypeptide binding]; other site
996285003102	putative phosphate binding site [ion binding]; other site
996285003103	putative allosteric binding site; other site
996285003104	PUA domain; Region: PUA; pfam01472
996285003105	CreA protein; Region: CreA; pfam05981
996285003106	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
996285003107	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
996285003108	MviN-like protein; Region: MVIN; pfam03023
996285003109	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
996285003110	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
996285003111	active site
996285003112	Riboflavin kinase; Region: Flavokinase; smart00904
996285003113	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
996285003114	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996285003115	active site
996285003116	HIGH motif; other site
996285003117	nucleotide binding site [chemical binding]; other site
996285003118	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
996285003119	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
996285003120	active site
996285003121	KMSKS motif; other site
996285003122	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
996285003123	tRNA binding surface [nucleotide binding]; other site
996285003124	anticodon binding site; other site
996285003125	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
996285003126	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
996285003127	lipoprotein signal peptidase; Provisional; Region: PRK14787
996285003128	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
996285003129	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996285003130	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
996285003131	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
996285003132	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
996285003133	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
996285003134	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
996285003135	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
996285003136	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
996285003137	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
996285003138	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
996285003139	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
996285003140	Type II transport protein GspH; Region: GspH; pfam12019
996285003141	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
996285003142	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
996285003143	translation initiation factor Sui1; Validated; Region: PRK06824
996285003144	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
996285003145	putative rRNA binding site [nucleotide binding]; other site
996285003146	arginine decarboxylase; Provisional; Region: PRK05354
996285003147	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
996285003148	dimer interface [polypeptide binding]; other site
996285003149	active site
996285003150	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996285003151	catalytic residues [active]
996285003152	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
996285003153	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
996285003154	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
996285003155	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
996285003156	SdiA-regulated; Region: SdiA-regulated; pfam06977
996285003157	SdiA-regulated; Region: SdiA-regulated; cd09971
996285003158	putative active site [active]
996285003159	Protein of unknown function, DUF606; Region: DUF606; pfam04657
996285003160	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
996285003161	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
996285003162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285003163	S-adenosylmethionine binding site [chemical binding]; other site
996285003164	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
996285003165	homodimer interface [polypeptide binding]; other site
996285003166	chemical substrate binding site [chemical binding]; other site
996285003167	oligomer interface [polypeptide binding]; other site
996285003168	metal binding site [ion binding]; metal-binding site
996285003169	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
996285003170	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
996285003171	DNA binding site [nucleotide binding]
996285003172	domain linker motif; other site
996285003173	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
996285003174	dimerization interface [polypeptide binding]; other site
996285003175	ligand binding site [chemical binding]; other site
996285003176	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
996285003177	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
996285003178	active site
996285003179	phosphorylation site [posttranslational modification]
996285003180	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
996285003181	regulatory protein interface [polypeptide binding]; other site
996285003182	active site
996285003183	regulatory phosphorylation site [posttranslational modification]; other site
996285003184	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
996285003185	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
996285003186	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
996285003187	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
996285003188	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
996285003189	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
996285003190	putative substrate binding site [chemical binding]; other site
996285003191	putative ATP binding site [chemical binding]; other site
996285003192	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
996285003193	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
996285003194	active site
996285003195	P-loop; other site
996285003196	phosphorylation site [posttranslational modification]
996285003197	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
996285003198	active site
996285003199	P-loop; other site
996285003200	phosphorylation site [posttranslational modification]
996285003201	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
996285003202	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
996285003203	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
996285003204	Trp docking motif [polypeptide binding]; other site
996285003205	putative active site [active]
996285003206	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
996285003207	putative active site [active]
996285003208	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
996285003209	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
996285003210	G1 box; other site
996285003211	putative GEF interaction site [polypeptide binding]; other site
996285003212	GTP/Mg2+ binding site [chemical binding]; other site
996285003213	Switch I region; other site
996285003214	G2 box; other site
996285003215	G3 box; other site
996285003216	Switch II region; other site
996285003217	G4 box; other site
996285003218	G5 box; other site
996285003219	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
996285003220	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
996285003221	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
996285003222	dimer interface [polypeptide binding]; other site
996285003223	active site
996285003224	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996285003225	catalytic residues [active]
996285003226	substrate binding site [chemical binding]; other site
996285003227	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
996285003228	Sel1-like repeats; Region: SEL1; smart00671
996285003229	Sel1-like repeats; Region: SEL1; smart00671
996285003230	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
996285003231	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
996285003232	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285003233	N-terminal plug; other site
996285003234	ligand-binding site [chemical binding]; other site
996285003235	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
996285003236	Flavodoxin; Region: Flavodoxin_1; pfam00258
996285003237	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
996285003238	FAD binding pocket [chemical binding]; other site
996285003239	FAD binding motif [chemical binding]; other site
996285003240	catalytic residues [active]
996285003241	NAD binding pocket [chemical binding]; other site
996285003242	phosphate binding motif [ion binding]; other site
996285003243	beta-alpha-beta structure motif; other site
996285003244	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
996285003245	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
996285003246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
996285003247	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
996285003248	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
996285003249	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285003250	N-terminal plug; other site
996285003251	ligand-binding site [chemical binding]; other site
996285003252	Protein of unknown function (DUF541); Region: SIMPL; cl01077
996285003253	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285003254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285003255	ATP binding site [chemical binding]; other site
996285003256	G-X-G motif; other site
996285003257	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
996285003258	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285003259	active site
996285003260	phosphorylation site [posttranslational modification]
996285003261	intermolecular recognition site; other site
996285003262	dimerization interface [polypeptide binding]; other site
996285003263	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285003264	Predicted permeases [General function prediction only]; Region: COG0679
996285003265	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
996285003266	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285003267	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
996285003268	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
996285003269	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
996285003270	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
996285003271	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
996285003272	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
996285003273	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
996285003274	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
996285003275	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
996285003276	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
996285003277	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
996285003278	GatB domain; Region: GatB_Yqey; smart00845
996285003279	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
996285003280	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
996285003281	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
996285003282	rod shape-determining protein MreB; Provisional; Region: PRK13927
996285003283	MreB and similar proteins; Region: MreB_like; cd10225
996285003284	nucleotide binding site [chemical binding]; other site
996285003285	Mg binding site [ion binding]; other site
996285003286	putative protofilament interaction site [polypeptide binding]; other site
996285003287	RodZ interaction site [polypeptide binding]; other site
996285003288	rod shape-determining protein MreC; Provisional; Region: PRK13922
996285003289	Baculovirus gp64 envelope glycoprotein family; Region: Baculo_gp64; pfam03273
996285003290	rod shape-determining protein MreC; Region: MreC; pfam04085
996285003291	rod shape-determining protein MreD; Region: MreD; cl01087
996285003292	PEGA domain; Region: PEGA; pfam08308
996285003293	Maf-like protein; Region: Maf; pfam02545
996285003294	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
996285003295	active site
996285003296	dimer interface [polypeptide binding]; other site
996285003297	ribonuclease G; Provisional; Region: PRK11712
996285003298	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
996285003299	homodimer interface [polypeptide binding]; other site
996285003300	oligonucleotide binding site [chemical binding]; other site
996285003301	TIGR02099 family protein; Region: TIGR02099
996285003302	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
996285003303	nitrilase; Region: PLN02798
996285003304	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
996285003305	putative active site [active]
996285003306	catalytic triad [active]
996285003307	dimer interface [polypeptide binding]; other site
996285003308	protease TldD; Provisional; Region: tldD; PRK10735
996285003309	hypothetical protein; Provisional; Region: PRK05255
996285003310	peptidase PmbA; Provisional; Region: PRK11040
996285003311	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
996285003312	dimerization domain swap beta strand [polypeptide binding]; other site
996285003313	regulatory protein interface [polypeptide binding]; other site
996285003314	active site
996285003315	regulatory phosphorylation site [posttranslational modification]; other site
996285003316	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
996285003317	AAA domain; Region: AAA_18; pfam13238
996285003318	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
996285003319	active site
996285003320	phosphorylation site [posttranslational modification]
996285003321	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
996285003322	30S subunit binding site; other site
996285003323	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
996285003324	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
996285003325	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
996285003326	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
996285003327	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
996285003328	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
996285003329	Walker A/P-loop; other site
996285003330	ATP binding site [chemical binding]; other site
996285003331	Q-loop/lid; other site
996285003332	ABC transporter signature motif; other site
996285003333	Walker B; other site
996285003334	D-loop; other site
996285003335	H-loop/switch region; other site
996285003336	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
996285003337	OstA-like protein; Region: OstA; pfam03968
996285003338	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
996285003339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
996285003340	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
996285003341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285003342	active site
996285003343	motif I; other site
996285003344	motif II; other site
996285003345	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
996285003346	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
996285003347	putative active site [active]
996285003348	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
996285003349	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
996285003350	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
996285003351	Walker A/P-loop; other site
996285003352	ATP binding site [chemical binding]; other site
996285003353	Q-loop/lid; other site
996285003354	ABC transporter signature motif; other site
996285003355	Walker B; other site
996285003356	D-loop; other site
996285003357	H-loop/switch region; other site
996285003358	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
996285003359	conserved hypothetical integral membrane protein; Region: TIGR00056
996285003360	mce related protein; Region: MCE; pfam02470
996285003361	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
996285003362	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
996285003363	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
996285003364	anti sigma factor interaction site; other site
996285003365	regulatory phosphorylation site [posttranslational modification]; other site
996285003366	Predicted membrane protein [Function unknown]; Region: COG3223
996285003367	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
996285003368	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
996285003369	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
996285003370	hinge; other site
996285003371	active site
996285003372	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
996285003373	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
996285003374	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
996285003375	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
996285003376	NAD binding site [chemical binding]; other site
996285003377	dimerization interface [polypeptide binding]; other site
996285003378	product binding site; other site
996285003379	substrate binding site [chemical binding]; other site
996285003380	zinc binding site [ion binding]; other site
996285003381	catalytic residues [active]
996285003382	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
996285003383	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285003384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285003385	homodimer interface [polypeptide binding]; other site
996285003386	catalytic residue [active]
996285003387	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
996285003388	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
996285003389	protein binding site [polypeptide binding]; other site
996285003390	Uncharacterized conserved protein [Function unknown]; Region: COG0327
996285003391	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
996285003392	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
996285003393	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
996285003394	Active Sites [active]
996285003395	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
996285003396	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
996285003397	CysD dimerization site [polypeptide binding]; other site
996285003398	G1 box; other site
996285003399	putative GEF interaction site [polypeptide binding]; other site
996285003400	GTP/Mg2+ binding site [chemical binding]; other site
996285003401	Switch I region; other site
996285003402	G2 box; other site
996285003403	G3 box; other site
996285003404	Switch II region; other site
996285003405	G4 box; other site
996285003406	G5 box; other site
996285003407	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
996285003408	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
996285003409	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
996285003410	ligand-binding site [chemical binding]; other site
996285003411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
996285003412	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
996285003413	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
996285003414	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
996285003415	Walker A motif; other site
996285003416	ATP binding site [chemical binding]; other site
996285003417	Walker B motif; other site
996285003418	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
996285003419	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
996285003420	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
996285003421	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
996285003422	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
996285003423	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
996285003424	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
996285003425	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
996285003426	CoA-binding site [chemical binding]; other site
996285003427	ATP-binding [chemical binding]; other site
996285003428	Predicted membrane protein [Function unknown]; Region: COG3235
996285003429	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996285003430	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996285003431	active site
996285003432	catalytic tetrad [active]
996285003433	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
996285003434	23S rRNA interface [nucleotide binding]; other site
996285003435	L3 interface [polypeptide binding]; other site
996285003436	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
996285003437	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
996285003438	iron-sulfur cluster [ion binding]; other site
996285003439	[2Fe-2S] cluster binding site [ion binding]; other site
996285003440	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
996285003441	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
996285003442	Qi binding site; other site
996285003443	intrachain domain interface; other site
996285003444	interchain domain interface [polypeptide binding]; other site
996285003445	heme bH binding site [chemical binding]; other site
996285003446	heme bL binding site [chemical binding]; other site
996285003447	Qo binding site; other site
996285003448	interchain domain interface [polypeptide binding]; other site
996285003449	intrachain domain interface; other site
996285003450	Qi binding site; other site
996285003451	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
996285003452	Qo binding site; other site
996285003453	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
996285003454	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
996285003455	stringent starvation protein A; Provisional; Region: sspA; PRK09481
996285003456	C-terminal domain interface [polypeptide binding]; other site
996285003457	putative GSH binding site (G-site) [chemical binding]; other site
996285003458	dimer interface [polypeptide binding]; other site
996285003459	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
996285003460	dimer interface [polypeptide binding]; other site
996285003461	N-terminal domain interface [polypeptide binding]; other site
996285003462	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
996285003463	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
996285003464	BON domain; Region: BON; pfam04972
996285003465	BON domain; Region: BON; pfam04972
996285003466	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
996285003467	dimer interface [polypeptide binding]; other site
996285003468	active site
996285003469	hypothetical protein; Reviewed; Region: PRK12497
996285003470	LppC putative lipoprotein; Region: LppC; pfam04348
996285003471	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
996285003472	putative ligand binding site [chemical binding]; other site
996285003473	Predicted methyltransferases [General function prediction only]; Region: COG0313
996285003474	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
996285003475	putative SAM binding site [chemical binding]; other site
996285003476	putative homodimer interface [polypeptide binding]; other site
996285003477	cell division protein MraZ; Reviewed; Region: PRK00326
996285003478	MraZ protein; Region: MraZ; pfam02381
996285003479	MraZ protein; Region: MraZ; pfam02381
996285003480	MraW methylase family; Region: Methyltransf_5; cl17771
996285003481	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
996285003482	Cell division protein FtsL; Region: FtsL; pfam04999
996285003483	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
996285003484	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
996285003485	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
996285003486	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
996285003487	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
996285003488	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996285003489	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996285003490	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
996285003491	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
996285003492	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996285003493	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996285003494	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
996285003495	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
996285003496	Mg++ binding site [ion binding]; other site
996285003497	putative catalytic motif [active]
996285003498	putative substrate binding site [chemical binding]; other site
996285003499	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
996285003500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285003501	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996285003502	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996285003503	cell division protein FtsW; Region: ftsW; TIGR02614
996285003504	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
996285003505	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
996285003506	active site
996285003507	homodimer interface [polypeptide binding]; other site
996285003508	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
996285003509	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
996285003510	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996285003511	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996285003512	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
996285003513	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
996285003514	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996285003515	potential frameshift: common BLAST hit: gi|146281471|ref|YP_001171624.1| cell division protein FtsQ
996285003516	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
996285003517	Cell division protein FtsQ; Region: FtsQ; pfam03799
996285003518	cell division protein FtsA; Region: ftsA; TIGR01174
996285003519	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
996285003520	nucleotide binding site [chemical binding]; other site
996285003521	Cell division protein FtsA; Region: FtsA; pfam14450
996285003522	cell division protein FtsZ; Validated; Region: PRK09330
996285003523	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
996285003524	nucleotide binding site [chemical binding]; other site
996285003525	SulA interaction site; other site
996285003526	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
996285003527	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
996285003528	Ferritin-like domain; Region: Ferritin; pfam00210
996285003529	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
996285003530	dinuclear metal binding motif [ion binding]; other site
996285003531	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
996285003532	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
996285003533	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
996285003534	MgtC family; Region: MgtC; pfam02308
996285003535	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
996285003536	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
996285003537	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
996285003538	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
996285003539	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
996285003540	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
996285003541	NAD binding site [chemical binding]; other site
996285003542	homodimer interface [polypeptide binding]; other site
996285003543	active site
996285003544	putative transporter; Provisional; Region: PRK11660
996285003545	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
996285003546	Sulfate transporter family; Region: Sulfate_transp; pfam00916
996285003547	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
996285003548	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
996285003549	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
996285003550	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
996285003551	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
996285003552	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
996285003553	putative acyl-acceptor binding pocket; other site
996285003554	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
996285003555	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
996285003556	Uncharacterized conserved protein [Function unknown]; Region: COG2135
996285003557	Cache domain; Region: Cache_1; pfam02743
996285003558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285003559	dimerization interface [polypeptide binding]; other site
996285003560	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285003561	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285003562	dimer interface [polypeptide binding]; other site
996285003563	putative CheW interface [polypeptide binding]; other site
996285003564	Peptidase family M48; Region: Peptidase_M48; pfam01435
996285003565	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
996285003566	Predicted membrane protein [Function unknown]; Region: COG2119
996285003567	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
996285003568	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
996285003569	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
996285003570	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
996285003571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285003572	S-adenosylmethionine binding site [chemical binding]; other site
996285003573	glycerate dehydrogenase; Provisional; Region: PRK06487
996285003574	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
996285003575	putative ligand binding site [chemical binding]; other site
996285003576	putative NAD binding site [chemical binding]; other site
996285003577	catalytic site [active]
996285003578	LysE type translocator; Region: LysE; cl00565
996285003579	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
996285003580	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996285003581	acyl-activating enzyme (AAE) consensus motif; other site
996285003582	AMP binding site [chemical binding]; other site
996285003583	active site
996285003584	CoA binding site [chemical binding]; other site
996285003585	PAS domain; Region: PAS_9; pfam13426
996285003586	PAS fold; Region: PAS_3; pfam08447
996285003587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285003588	ATP binding site [chemical binding]; other site
996285003589	G-X-G motif; other site
996285003590	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285003591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285003592	active site
996285003593	phosphorylation site [posttranslational modification]
996285003594	intermolecular recognition site; other site
996285003595	dimerization interface [polypeptide binding]; other site
996285003596	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996285003597	putative outer membrane lipoprotein; Provisional; Region: PRK10510
996285003598	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285003599	ligand binding site [chemical binding]; other site
996285003600	CHASE domain; Region: CHASE; pfam03924
996285003601	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285003602	PAS domain; Region: PAS_9; pfam13426
996285003603	putative active site [active]
996285003604	heme pocket [chemical binding]; other site
996285003605	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996285003606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285003607	putative active site [active]
996285003608	heme pocket [chemical binding]; other site
996285003609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285003610	dimer interface [polypeptide binding]; other site
996285003611	phosphorylation site [posttranslational modification]
996285003612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285003613	ATP binding site [chemical binding]; other site
996285003614	Mg2+ binding site [ion binding]; other site
996285003615	G-X-G motif; other site
996285003616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285003617	Response regulator receiver domain; Region: Response_reg; pfam00072
996285003618	active site
996285003619	phosphorylation site [posttranslational modification]
996285003620	intermolecular recognition site; other site
996285003621	dimerization interface [polypeptide binding]; other site
996285003622	Response regulator receiver domain; Region: Response_reg; pfam00072
996285003623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285003624	active site
996285003625	phosphorylation site [posttranslational modification]
996285003626	intermolecular recognition site; other site
996285003627	dimerization interface [polypeptide binding]; other site
996285003628	Response regulator receiver domain; Region: Response_reg; pfam00072
996285003629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285003630	active site
996285003631	phosphorylation site [posttranslational modification]
996285003632	intermolecular recognition site; other site
996285003633	dimerization interface [polypeptide binding]; other site
996285003634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285003635	putative active site [active]
996285003636	heme pocket [chemical binding]; other site
996285003637	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285003638	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285003639	metal binding site [ion binding]; metal-binding site
996285003640	active site
996285003641	I-site; other site
996285003642	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285003643	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
996285003644	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
996285003645	putative acyl-acceptor binding pocket; other site
996285003646	phosphate acetyltransferase; Reviewed; Region: PRK05632
996285003647	DRTGG domain; Region: DRTGG; pfam07085
996285003648	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
996285003649	propionate/acetate kinase; Provisional; Region: PRK12379
996285003650	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
996285003651	nucleotide binding site [chemical binding]; other site
996285003652	butyrate kinase; Provisional; Region: PRK03011
996285003653	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
996285003654	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996285003655	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
996285003656	catalytic residues [active]
996285003657	dimer interface [polypeptide binding]; other site
996285003658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285003659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285003660	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
996285003661	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
996285003662	putative active site [active]
996285003663	putative FMN binding site [chemical binding]; other site
996285003664	putative substrate binding site [chemical binding]; other site
996285003665	putative catalytic residue [active]
996285003666	putative sulfate transport protein CysZ; Validated; Region: PRK04949
996285003667	HopJ type III effector protein; Region: HopJ; pfam08888
996285003668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
996285003669	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
996285003670	homooctamer interface [polypeptide binding]; other site
996285003671	active site
996285003672	dihydromonapterin reductase; Provisional; Region: PRK06483
996285003673	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
996285003674	NADP binding site [chemical binding]; other site
996285003675	substrate binding pocket [chemical binding]; other site
996285003676	active site
996285003677	PilZ domain; Region: PilZ; pfam07238
996285003678	flavodoxin; Provisional; Region: PRK05723
996285003679	aldolase II superfamily protein; Provisional; Region: PRK07044
996285003680	intersubunit interface [polypeptide binding]; other site
996285003681	active site
996285003682	Zn2+ binding site [ion binding]; other site
996285003683	Protein of unknown function, DUF479; Region: DUF479; cl01203
996285003684	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
996285003685	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
996285003686	putative acyl-acceptor binding pocket; other site
996285003687	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
996285003688	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285003689	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
996285003690	putative active site [active]
996285003691	catalytic site [active]
996285003692	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
996285003693	PLD-like domain; Region: PLDc_2; pfam13091
996285003694	putative active site [active]
996285003695	catalytic site [active]
996285003696	intracellular protease, PfpI family; Region: PfpI; TIGR01382
996285003697	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
996285003698	conserved cys residue [active]
996285003699	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
996285003700	putative fumarate hydratase; Provisional; Region: PRK15392
996285003701	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
996285003702	Fumarase C-terminus; Region: Fumerase_C; pfam05683
996285003703	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285003704	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285003705	metal binding site [ion binding]; metal-binding site
996285003706	active site
996285003707	I-site; other site
996285003708	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285003709	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
996285003710	FAD binding pocket [chemical binding]; other site
996285003711	FAD binding motif [chemical binding]; other site
996285003712	phosphate binding motif [ion binding]; other site
996285003713	beta-alpha-beta structure motif; other site
996285003714	NAD binding pocket [chemical binding]; other site
996285003715	pyruvate kinase; Provisional; Region: PRK05826
996285003716	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
996285003717	domain interfaces; other site
996285003718	active site
996285003719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
996285003720	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285003721	PilZ domain; Region: PilZ; pfam07238
996285003722	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
996285003723	Protein of unknown function DUF58; Region: DUF58; pfam01882
996285003724	MoxR-like ATPases [General function prediction only]; Region: COG0714
996285003725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285003726	Walker A motif; other site
996285003727	ATP binding site [chemical binding]; other site
996285003728	Walker B motif; other site
996285003729	arginine finger; other site
996285003730	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
996285003731	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
996285003732	RDD family; Region: RDD; pfam06271
996285003733	exonuclease I; Provisional; Region: sbcB; PRK11779
996285003734	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
996285003735	active site
996285003736	catalytic site [active]
996285003737	substrate binding site [chemical binding]; other site
996285003738	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
996285003739	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
996285003740	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
996285003741	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
996285003742	putative active site [active]
996285003743	putative substrate binding site [chemical binding]; other site
996285003744	putative cosubstrate binding site; other site
996285003745	catalytic site [active]
996285003746	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
996285003747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996285003748	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
996285003749	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
996285003750	Substrate binding site; other site
996285003751	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
996285003752	hypothetical protein; Validated; Region: PRK02101
996285003753	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
996285003754	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
996285003755	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
996285003756	putative active site [active]
996285003757	PhoH-like protein; Region: PhoH; pfam02562
996285003758	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
996285003759	trimer interface [polypeptide binding]; other site
996285003760	dimer interface [polypeptide binding]; other site
996285003761	putative active site [active]
996285003762	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
996285003763	MoaE interaction surface [polypeptide binding]; other site
996285003764	MoeB interaction surface [polypeptide binding]; other site
996285003765	thiocarboxylated glycine; other site
996285003766	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
996285003767	MoaE homodimer interface [polypeptide binding]; other site
996285003768	MoaD interaction [polypeptide binding]; other site
996285003769	active site residues [active]
996285003770	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297
996285003771	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996285003772	ATP binding site [chemical binding]; other site
996285003773	Mg++ binding site [ion binding]; other site
996285003774	motif III; other site
996285003775	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285003776	nucleotide binding region [chemical binding]; other site
996285003777	ATP-binding site [chemical binding]; other site
996285003778	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
996285003779	putative hydrolase; Provisional; Region: PRK11460
996285003780	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
996285003781	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285003782	substrate binding pocket [chemical binding]; other site
996285003783	membrane-bound complex binding site; other site
996285003784	hinge residues; other site
996285003785	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
996285003786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285003787	conserved gate region; other site
996285003788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285003789	putative PBP binding loops; other site
996285003790	dimer interface [polypeptide binding]; other site
996285003791	ABC-ATPase subunit interface; other site
996285003792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285003793	dimer interface [polypeptide binding]; other site
996285003794	conserved gate region; other site
996285003795	putative PBP binding loops; other site
996285003796	ABC-ATPase subunit interface; other site
996285003797	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
996285003798	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
996285003799	Walker A/P-loop; other site
996285003800	ATP binding site [chemical binding]; other site
996285003801	Q-loop/lid; other site
996285003802	ABC transporter signature motif; other site
996285003803	Walker B; other site
996285003804	D-loop; other site
996285003805	H-loop/switch region; other site
996285003806	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
996285003807	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
996285003808	dimerization interface [polypeptide binding]; other site
996285003809	ATP binding site [chemical binding]; other site
996285003810	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
996285003811	dimerization interface [polypeptide binding]; other site
996285003812	ATP binding site [chemical binding]; other site
996285003813	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
996285003814	putative active site [active]
996285003815	catalytic triad [active]
996285003816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
996285003817	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
996285003818	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
996285003819	nudix motif; other site
996285003820	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
996285003821	putative active site [active]
996285003822	putative CoA binding site [chemical binding]; other site
996285003823	nudix motif; other site
996285003824	metal binding site [ion binding]; metal-binding site
996285003825	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
996285003826	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
996285003827	trimer interface [polypeptide binding]; other site
996285003828	putative metal binding site [ion binding]; other site
996285003829	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
996285003830	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
996285003831	ATP-grasp domain; Region: ATP-grasp; pfam02222
996285003832	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
996285003833	Domain of unknown function DUF21; Region: DUF21; pfam01595
996285003834	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
996285003835	Transporter associated domain; Region: CorC_HlyC; smart01091
996285003836	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
996285003837	signal recognition particle protein; Provisional; Region: PRK10867
996285003838	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
996285003839	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
996285003840	P loop; other site
996285003841	GTP binding site [chemical binding]; other site
996285003842	Signal peptide binding domain; Region: SRP_SPB; pfam02978
996285003843	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
996285003844	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
996285003845	RimM N-terminal domain; Region: RimM; pfam01782
996285003846	PRC-barrel domain; Region: PRC; pfam05239
996285003847	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
996285003848	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
996285003849	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
996285003850	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
996285003851	active site
996285003852	Int/Topo IB signature motif; other site
996285003853	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
996285003854	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
996285003855	dimerization domain [polypeptide binding]; other site
996285003856	dimer interface [polypeptide binding]; other site
996285003857	catalytic residues [active]
996285003858	Uncharacterized conserved protein [Function unknown]; Region: COG3791
996285003859	homoserine dehydrogenase; Provisional; Region: PRK06349
996285003860	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
996285003861	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
996285003862	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
996285003863	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
996285003864	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
996285003865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285003866	catalytic residue [active]
996285003867	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
996285003868	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
996285003869	dimer interface [polypeptide binding]; other site
996285003870	catalytic site [active]
996285003871	putative active site [active]
996285003872	putative substrate binding site [chemical binding]; other site
996285003873	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
996285003874	active site
996285003875	substrate binding pocket [chemical binding]; other site
996285003876	dimer interface [polypeptide binding]; other site
996285003877	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285003878	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285003879	ligand binding site [chemical binding]; other site
996285003880	argininosuccinate synthase; Provisional; Region: PRK13820
996285003881	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
996285003882	ANP binding site [chemical binding]; other site
996285003883	Substrate Binding Site II [chemical binding]; other site
996285003884	Substrate Binding Site I [chemical binding]; other site
996285003885	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285003886	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
996285003887	dimer interface [polypeptide binding]; other site
996285003888	active site
996285003889	metal binding site [ion binding]; metal-binding site
996285003890	glutathione binding site [chemical binding]; other site
996285003891	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
996285003892	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
996285003893	minor groove reading motif; other site
996285003894	helix-hairpin-helix signature motif; other site
996285003895	substrate binding pocket [chemical binding]; other site
996285003896	active site
996285003897	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
996285003898	electron transport complex RsxE subunit; Provisional; Region: PRK12405
996285003899	FMN-binding domain; Region: FMN_bind; cl01081
996285003900	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
996285003901	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
996285003902	SLBB domain; Region: SLBB; pfam10531
996285003903	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285003904	ferredoxin; Provisional; Region: PRK08764
996285003905	Putative Fe-S cluster; Region: FeS; pfam04060
996285003906	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
996285003907	electron transport complex protein RsxA; Provisional; Region: PRK05151
996285003908	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
996285003909	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285003910	substrate binding site [chemical binding]; other site
996285003911	oxyanion hole (OAH) forming residues; other site
996285003912	trimer interface [polypeptide binding]; other site
996285003913	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
996285003914	enoyl-CoA hydratase; Provisional; Region: PRK09076
996285003915	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285003916	substrate binding site [chemical binding]; other site
996285003917	oxyanion hole (OAH) forming residues; other site
996285003918	trimer interface [polypeptide binding]; other site
996285003919	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
996285003920	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
996285003921	putative ligand binding site [chemical binding]; other site
996285003922	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
996285003923	ligand binding site [chemical binding]; other site
996285003924	active site
996285003925	UGI interface [polypeptide binding]; other site
996285003926	catalytic site [active]
996285003927	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
996285003928	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
996285003929	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
996285003930	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
996285003931	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
996285003932	Uncharacterized conserved protein [Function unknown]; Region: COG2938
996285003933	L-aspartate oxidase; Provisional; Region: PRK09077
996285003934	L-aspartate oxidase; Provisional; Region: PRK06175
996285003935	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
996285003936	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
996285003937	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285003938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285003939	DNA binding residues [nucleotide binding]
996285003940	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
996285003941	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
996285003942	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
996285003943	MucB/RseB family; Region: MucB_RseB; pfam03888
996285003944	anti-sigma E factor; Provisional; Region: rseB; PRK09455
996285003945	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
996285003946	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
996285003947	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
996285003948	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
996285003949	protein binding site [polypeptide binding]; other site
996285003950	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
996285003951	protein binding site [polypeptide binding]; other site
996285003952	GTP-binding protein LepA; Provisional; Region: PRK05433
996285003953	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
996285003954	G1 box; other site
996285003955	putative GEF interaction site [polypeptide binding]; other site
996285003956	GTP/Mg2+ binding site [chemical binding]; other site
996285003957	Switch I region; other site
996285003958	G2 box; other site
996285003959	G3 box; other site
996285003960	Switch II region; other site
996285003961	G4 box; other site
996285003962	G5 box; other site
996285003963	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
996285003964	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
996285003965	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
996285003966	signal peptidase I; Provisional; Region: PRK10861
996285003967	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
996285003968	Catalytic site [active]
996285003969	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
996285003970	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
996285003971	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
996285003972	dimerization interface [polypeptide binding]; other site
996285003973	active site
996285003974	metal binding site [ion binding]; metal-binding site
996285003975	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
996285003976	GTPase Era; Reviewed; Region: era; PRK00089
996285003977	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
996285003978	G1 box; other site
996285003979	GTP/Mg2+ binding site [chemical binding]; other site
996285003980	Switch I region; other site
996285003981	G2 box; other site
996285003982	Switch II region; other site
996285003983	G3 box; other site
996285003984	G4 box; other site
996285003985	G5 box; other site
996285003986	KH domain; Region: KH_2; pfam07650
996285003987	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
996285003988	Recombination protein O N terminal; Region: RecO_N; pfam11967
996285003989	Recombination protein O C terminal; Region: RecO_C; pfam02565
996285003990	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
996285003991	active site
996285003992	hydrophilic channel; other site
996285003993	dimerization interface [polypeptide binding]; other site
996285003994	catalytic residues [active]
996285003995	active site lid [active]
996285003996	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
996285003997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285003998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285003999	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285004000	dimerization interface [polypeptide binding]; other site
996285004001	Methyltransferase domain; Region: Methyltransf_31; pfam13847
996285004002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285004003	S-adenosylmethionine binding site [chemical binding]; other site
996285004004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285004005	S-adenosylmethionine binding site [chemical binding]; other site
996285004006	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
996285004007	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
996285004008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285004009	Walker A motif; other site
996285004010	ATP binding site [chemical binding]; other site
996285004011	Walker B motif; other site
996285004012	arginine finger; other site
996285004013	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
996285004014	Cupin domain; Region: Cupin_2; cl17218
996285004015	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285004016	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285004017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285004018	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
996285004019	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
996285004020	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
996285004021	Glutamate binding site [chemical binding]; other site
996285004022	NAD binding site [chemical binding]; other site
996285004023	catalytic residues [active]
996285004024	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
996285004025	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
996285004026	Na binding site [ion binding]; other site
996285004027	Protein of unknown function (DUF3203); Region: DUF3203; pfam11462
996285004028	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
996285004029	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285004030	N-terminal plug; other site
996285004031	ligand-binding site [chemical binding]; other site
996285004032	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
996285004033	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
996285004034	Na binding site [ion binding]; other site
996285004035	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
996285004036	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
996285004037	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
996285004038	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285004039	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285004040	dimerization interface [polypeptide binding]; other site
996285004041	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
996285004042	heterodimer interface [polypeptide binding]; other site
996285004043	multimer interface [polypeptide binding]; other site
996285004044	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
996285004045	active site
996285004046	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
996285004047	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
996285004048	heterodimer interface [polypeptide binding]; other site
996285004049	active site
996285004050	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
996285004051	Predicted permeases [General function prediction only]; Region: COG0679
996285004052	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
996285004053	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
996285004054	Bacterial transcriptional regulator; Region: IclR; pfam01614
996285004055	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
996285004056	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
996285004057	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
996285004058	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
996285004059	dimer interface [polypeptide binding]; other site
996285004060	active site
996285004061	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
996285004062	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
996285004063	tetramer interface [polypeptide binding]; other site
996285004064	active site
996285004065	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
996285004066	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
996285004067	LysR substrate binding domain; Region: LysR_substrate; pfam03466
996285004068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
996285004069	salt bridge; other site
996285004070	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285004071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285004072	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
996285004073	dimerization interface [polypeptide binding]; other site
996285004074	substrate binding pocket [chemical binding]; other site
996285004075	Predicted transcriptional regulator [Transcription]; Region: COG2378
996285004076	WYL domain; Region: WYL; pfam13280
996285004077	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
996285004078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285004079	ATP binding site [chemical binding]; other site
996285004080	putative Mg++ binding site [ion binding]; other site
996285004081	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
996285004082	Outer membrane efflux protein; Region: OEP; pfam02321
996285004083	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
996285004084	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285004085	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
996285004086	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
996285004087	Putative Catalytic site; other site
996285004088	DXD motif; other site
996285004089	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
996285004090	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
996285004091	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
996285004092	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285004093	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
996285004094	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285004095	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285004096	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
996285004097	dimerization interface [polypeptide binding]; other site
996285004098	substrate binding pocket [chemical binding]; other site
996285004099	Transposase domain (DUF772); Region: DUF772; pfam05598
996285004100	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285004101	Protein of unknown function (DUF 659); Region: DUF659; pfam04937
996285004102	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285004103	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
996285004104	Putative helicase; Region: TraI_2; pfam07514
996285004105	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
996285004106	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
996285004107	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
996285004108	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
996285004109	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
996285004110	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
996285004111	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
996285004112	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
996285004113	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
996285004114	MPN+ (JAMM) motif; other site
996285004115	Zinc-binding site [ion binding]; other site
996285004116	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
996285004117	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
996285004118	catalytic residues [active]
996285004119	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
996285004120	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
996285004121	ParA/MinD ATPase like; Region: ParA; pfam10609
996285004122	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
996285004123	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
996285004124	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
996285004125	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
996285004126	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
996285004127	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
996285004128	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
996285004129	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
996285004130	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
996285004131	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
996285004132	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
996285004133	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
996285004134	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
996285004135	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
996285004136	catalytic residue [active]
996285004137	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
996285004138	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
996285004139	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996285004140	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285004141	nucleotide binding region [chemical binding]; other site
996285004142	ATP-binding site [chemical binding]; other site
996285004143	Methyltransferase domain; Region: Methyltransf_26; pfam13659
996285004144	S-adenosylmethionine binding site [chemical binding]; other site
996285004145	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
996285004146	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
996285004147	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
996285004148	DNA topoisomerase III; Provisional; Region: PRK07726
996285004149	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
996285004150	active site
996285004151	putative interdomain interaction site [polypeptide binding]; other site
996285004152	putative metal-binding site [ion binding]; other site
996285004153	putative nucleotide binding site [chemical binding]; other site
996285004154	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
996285004155	domain I; other site
996285004156	DNA binding groove [nucleotide binding]
996285004157	phosphate binding site [ion binding]; other site
996285004158	domain II; other site
996285004159	domain III; other site
996285004160	nucleotide binding site [chemical binding]; other site
996285004161	catalytic site [active]
996285004162	domain IV; other site
996285004163	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
996285004164	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
996285004165	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
996285004166	ssDNA binding site [nucleotide binding]; other site
996285004167	dimer interface [polypeptide binding]; other site
996285004168	tetramer (dimer of dimers) interface [polypeptide binding]; other site
996285004169	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
996285004170	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
996285004171	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
996285004172	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
996285004173	ParB-like nuclease domain; Region: ParBc; pfam02195
996285004174	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
996285004175	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285004176	Magnesium ion binding site [ion binding]; other site
996285004177	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
996285004178	integrase; Provisional; Region: PRK09692
996285004179	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
996285004180	active site
996285004181	Int/Topo IB signature motif; other site
996285004182	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
996285004183	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285004184	RNA binding surface [nucleotide binding]; other site
996285004185	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
996285004186	active site
996285004187	uracil binding [chemical binding]; other site
996285004188	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
996285004189	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
996285004190	active site
996285004191	HIGH motif; other site
996285004192	KMSKS motif; other site
996285004193	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
996285004194	anticodon binding site; other site
996285004195	tRNA binding surface [nucleotide binding]; other site
996285004196	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
996285004197	dimer interface [polypeptide binding]; other site
996285004198	putative tRNA-binding site [nucleotide binding]; other site
996285004199	antiporter inner membrane protein; Provisional; Region: PRK11670
996285004200	Domain of unknown function DUF59; Region: DUF59; pfam01883
996285004201	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
996285004202	Walker A motif; other site
996285004203	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996285004204	DNA-binding site [nucleotide binding]; DNA binding site
996285004205	RNA-binding motif; other site
996285004206	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
996285004207	trimer interface [polypeptide binding]; other site
996285004208	active site
996285004209	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
996285004210	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
996285004211	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
996285004212	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
996285004213	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
996285004214	[4Fe-4S] binding site [ion binding]; other site
996285004215	molybdopterin cofactor binding site; other site
996285004216	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
996285004217	molybdopterin cofactor binding site; other site
996285004218	NapD protein; Region: NapD; pfam03927
996285004219	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
996285004220	hypothetical protein; Provisional; Region: PRK04860
996285004221	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
996285004222	Yip1 domain; Region: Yip1; pfam04893
996285004223	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
996285004224	DNA-J related protein; Region: DNAJ_related; pfam12339
996285004225	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
996285004226	HSP70 interaction site [polypeptide binding]; other site
996285004227	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
996285004228	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
996285004229	Ligand Binding Site [chemical binding]; other site
996285004230	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
996285004231	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
996285004232	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
996285004233	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
996285004234	AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061
996285004235	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
996285004236	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
996285004237	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
996285004238	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
996285004239	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
996285004240	NAD-dependent deacetylase; Provisional; Region: PRK00481
996285004241	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
996285004242	NAD+ binding site [chemical binding]; other site
996285004243	substrate binding site [chemical binding]; other site
996285004244	Zn binding site [ion binding]; other site
996285004245	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996285004246	NlpC/P60 family; Region: NLPC_P60; pfam00877
996285004247	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
996285004248	NlpC/P60 family; Region: NLPC_P60; pfam00877
996285004249	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
996285004250	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
996285004251	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
996285004252	putative active site [active]
996285004253	putative metal binding site [ion binding]; other site
996285004254	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
996285004255	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
996285004256	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285004257	N-terminal plug; other site
996285004258	ligand-binding site [chemical binding]; other site
996285004259	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
996285004260	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
996285004261	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
996285004262	Walker A motif; other site
996285004263	homodimer interface [polypeptide binding]; other site
996285004264	ATP binding site [chemical binding]; other site
996285004265	hydroxycobalamin binding site [chemical binding]; other site
996285004266	Walker B motif; other site
996285004267	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
996285004268	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
996285004269	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
996285004270	catalytic triad [active]
996285004271	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
996285004272	putative FMN binding site [chemical binding]; other site
996285004273	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
996285004274	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
996285004275	cobalamin binding residues [chemical binding]; other site
996285004276	putative BtuC binding residues; other site
996285004277	dimer interface [polypeptide binding]; other site
996285004278	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
996285004279	threonine-phosphate decarboxylase; Reviewed; Region: PRK05664
996285004280	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
996285004281	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285004282	catalytic residue [active]
996285004283	cobyric acid synthase; Provisional; Region: PRK00784
996285004284	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
996285004285	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
996285004286	catalytic triad [active]
996285004287	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
996285004288	homotrimer interface [polypeptide binding]; other site
996285004289	Walker A motif; other site
996285004290	GTP binding site [chemical binding]; other site
996285004291	Walker B motif; other site
996285004292	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
996285004293	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
996285004294	putative dimer interface [polypeptide binding]; other site
996285004295	active site pocket [active]
996285004296	putative cataytic base [active]
996285004297	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996285004298	catalytic core [active]
996285004299	cobalamin synthase; Reviewed; Region: cobS; PRK00235
996285004300	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
996285004301	putative GSH binding site [chemical binding]; other site
996285004302	catalytic residues [active]
996285004303	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
996285004304	active site residue [active]
996285004305	NifQ; Region: NifQ; pfam04891
996285004306	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
996285004307	putative catalytic residues [active]
996285004308	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
996285004309	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
996285004310	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285004311	FeS/SAM binding site; other site
996285004312	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
996285004313	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285004314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285004315	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
996285004316	putative effector binding pocket; other site
996285004317	putative dimerization interface [polypeptide binding]; other site
996285004318	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
996285004319	homotrimer interaction site [polypeptide binding]; other site
996285004320	putative active site [active]
996285004321	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
996285004322	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285004323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285004324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285004325	putative substrate translocation pore; other site
996285004326	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285004327	Nif-specific regulatory protein; Region: nifA; TIGR01817
996285004328	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
996285004329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285004330	Walker A motif; other site
996285004331	ATP binding site [chemical binding]; other site
996285004332	Walker B motif; other site
996285004333	arginine finger; other site
996285004334	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285004335	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
996285004336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285004337	putative active site [active]
996285004338	heme pocket [chemical binding]; other site
996285004339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285004340	ATP binding site [chemical binding]; other site
996285004341	Mg2+ binding site [ion binding]; other site
996285004342	G-X-G motif; other site
996285004343	electron transport complex protein RsxA; Provisional; Region: PRK05151
996285004344	ferredoxin; Provisional; Region: PRK08764
996285004345	Putative Fe-S cluster; Region: FeS; cl17515
996285004346	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285004347	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
996285004348	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
996285004349	SLBB domain; Region: SLBB; pfam10531
996285004350	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285004351	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
996285004352	electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947
996285004353	electron transport complex RsxE subunit; Provisional; Region: PRK12405
996285004354	RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658
996285004355	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
996285004356	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
996285004357	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
996285004358	nitrogenase iron protein; Region: nifH; TIGR01287
996285004359	Nucleotide-binding sites [chemical binding]; other site
996285004360	Walker A motif; other site
996285004361	Switch I region of nucleotide binding site; other site
996285004362	Fe4S4 binding sites [ion binding]; other site
996285004363	Switch II region of nucleotide binding site; other site
996285004364	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
996285004365	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
996285004366	MoFe protein alpha/beta subunit interactions; other site
996285004367	Alpha subunit P cluster binding residues; other site
996285004368	FeMoco binding residues [chemical binding]; other site
996285004369	MoFe protein alpha subunit/Fe protein contacts; other site
996285004370	MoFe protein dimer/ dimer interactions; other site
996285004371	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
996285004372	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
996285004373	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
996285004374	MoFe protein beta/alpha subunit interactions; other site
996285004375	Beta subunit P cluster binding residues; other site
996285004376	MoFe protein beta subunit/Fe protein contacts; other site
996285004377	MoFe protein dimer/ dimer interactions; other site
996285004378	NifT/FixU protein; Region: NifT; pfam06988
996285004379	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
996285004380	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
996285004381	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
996285004382	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
996285004383	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
996285004384	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
996285004385	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
996285004386	probable nitrogen fixation protein; Region: TIGR02935
996285004387	Rop-like; Region: Rop-like; pfam05082
996285004388	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
996285004389	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
996285004390	dimer interface [polypeptide binding]; other site
996285004391	[2Fe-2S] cluster binding site [ion binding]; other site
996285004392	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
996285004393	Domain of unknown function (DUF364); Region: DUF364; pfam04016
996285004394	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
996285004395	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
996285004396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285004397	Walker A/P-loop; other site
996285004398	ATP binding site [chemical binding]; other site
996285004399	Q-loop/lid; other site
996285004400	ABC transporter signature motif; other site
996285004401	Walker B; other site
996285004402	D-loop; other site
996285004403	H-loop/switch region; other site
996285004404	TOBE domain; Region: TOBE; cl01440
996285004405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285004406	putative PBP binding loops; other site
996285004407	dimer interface [polypeptide binding]; other site
996285004408	ABC-ATPase subunit interface; other site
996285004409	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
996285004410	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
996285004411	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
996285004412	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
996285004413	molybdenum-pterin binding domain; Region: Mop; TIGR00638
996285004414	molybdenum-pterin binding domain; Region: Mop; TIGR00638
996285004415	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
996285004416	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
996285004417	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
996285004418	trimerization site [polypeptide binding]; other site
996285004419	active site
996285004420	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
996285004421	NifU-like domain; Region: NifU; pfam01106
996285004422	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
996285004423	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
996285004424	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285004425	catalytic residue [active]
996285004426	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
996285004427	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
996285004428	active site
996285004429	catalytic residues [active]
996285004430	metal binding site [ion binding]; metal-binding site
996285004431	serine O-acetyltransferase; Region: cysE; TIGR01172
996285004432	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
996285004433	trimer interface [polypeptide binding]; other site
996285004434	active site
996285004435	substrate binding site [chemical binding]; other site
996285004436	CoA binding site [chemical binding]; other site
996285004437	Nitrogen fixation protein NifW; Region: NifW; pfam03206
996285004438	NifZ domain; Region: NifZ; pfam04319
996285004439	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
996285004440	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
996285004441	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
996285004442	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
996285004443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285004444	Walker A motif; other site
996285004445	ATP binding site [chemical binding]; other site
996285004446	Walker B motif; other site
996285004447	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
996285004448	flavodoxin FldA; Validated; Region: PRK09267
996285004449	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
996285004450	catalytic residues [active]
996285004451	dimer interface [polypeptide binding]; other site
996285004452	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
996285004453	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
996285004454	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
996285004455	active site residue [active]
996285004456	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
996285004457	active site residue [active]
996285004458	ribonuclease D; Region: rnd; TIGR01388
996285004459	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
996285004460	catalytic site [active]
996285004461	putative active site [active]
996285004462	putative substrate binding site [chemical binding]; other site
996285004463	HRDC domain; Region: HRDC; pfam00570
996285004464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
996285004465	hypothetical protein; Provisional; Region: PRK05170
996285004466	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
996285004467	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
996285004468	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
996285004469	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
996285004470	tetramer interface [polypeptide binding]; other site
996285004471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285004472	catalytic residue [active]
996285004473	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
996285004474	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
996285004475	motif 1; other site
996285004476	active site
996285004477	motif 2; other site
996285004478	motif 3; other site
996285004479	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
996285004480	DHHA1 domain; Region: DHHA1; pfam02272
996285004481	aspartate kinase; Reviewed; Region: PRK06635
996285004482	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
996285004483	putative nucleotide binding site [chemical binding]; other site
996285004484	putative catalytic residues [active]
996285004485	putative Mg ion binding site [ion binding]; other site
996285004486	putative aspartate binding site [chemical binding]; other site
996285004487	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
996285004488	putative allosteric regulatory site; other site
996285004489	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
996285004490	putative allosteric regulatory residue; other site
996285004491	carbon storage regulator; Provisional; Region: PRK01712
996285004492	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285004493	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
996285004494	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
996285004495	MgtE intracellular N domain; Region: MgtE_N; smart00924
996285004496	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
996285004497	Divalent cation transporter; Region: MgtE; cl00786
996285004498	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
996285004499	oxaloacetate decarboxylase; Provisional; Region: PRK14040
996285004500	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
996285004501	active site
996285004502	catalytic residues [active]
996285004503	metal binding site [ion binding]; metal-binding site
996285004504	homodimer binding site [polypeptide binding]; other site
996285004505	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996285004506	carboxyltransferase (CT) interaction site; other site
996285004507	biotinylation site [posttranslational modification]; other site
996285004508	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
996285004509	Arc-like DNA binding domain; Region: Arc; pfam03869
996285004510	Flagellar regulator YcgR; Region: YcgR; pfam07317
996285004511	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
996285004512	PilZ domain; Region: PilZ; pfam07238
996285004513	FlgN protein; Region: FlgN; pfam05130
996285004514	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
996285004515	SAF-like; Region: SAF_2; pfam13144
996285004516	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
996285004517	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
996285004518	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
996285004519	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285004520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285004521	active site
996285004522	phosphorylation site [posttranslational modification]
996285004523	intermolecular recognition site; other site
996285004524	dimerization interface [polypeptide binding]; other site
996285004525	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
996285004526	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
996285004527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285004528	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
996285004529	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
996285004530	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
996285004531	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
996285004532	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285004533	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
996285004534	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
996285004535	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
996285004536	flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637
996285004537	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
996285004538	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
996285004539	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285004540	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
996285004541	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
996285004542	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
996285004543	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
996285004544	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285004545	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
996285004546	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
996285004547	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
996285004548	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
996285004549	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
996285004550	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
996285004551	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
996285004552	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
996285004553	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
996285004554	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
996285004555	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
996285004556	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
996285004557	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
996285004558	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
996285004559	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285004560	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
996285004561	non-specific DNA binding site [nucleotide binding]; other site
996285004562	salt bridge; other site
996285004563	sequence-specific DNA binding site [nucleotide binding]; other site
996285004564	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
996285004565	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285004566	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
996285004567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285004568	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285004569	metal binding site [ion binding]; metal-binding site
996285004570	active site
996285004571	I-site; other site
996285004572	carboxy-terminal protease; Provisional; Region: PRK11186
996285004573	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
996285004574	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
996285004575	protein binding site [polypeptide binding]; other site
996285004576	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
996285004577	Catalytic dyad [active]
996285004578	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
996285004579	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
996285004580	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
996285004581	NAD(P) binding site [chemical binding]; other site
996285004582	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
996285004583	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
996285004584	active site
996285004585	metal binding site [ion binding]; metal-binding site
996285004586	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
996285004587	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
996285004588	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
996285004589	active site
996285004590	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
996285004591	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
996285004592	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
996285004593	Switch I; other site
996285004594	Switch II; other site
996285004595	septum formation inhibitor; Reviewed; Region: minC; PRK00339
996285004596	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
996285004597	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
996285004598	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
996285004599	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
996285004600	putative acyl-acceptor binding pocket; other site
996285004601	Pirin-related protein [General function prediction only]; Region: COG1741
996285004602	Pirin; Region: Pirin; pfam02678
996285004603	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
996285004604	VacJ like lipoprotein; Region: VacJ; cl01073
996285004605	Predicted membrane protein [Function unknown]; Region: COG3205
996285004606	Predicted membrane protein [Function unknown]; Region: COG3162
996285004607	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
996285004608	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
996285004609	Na binding site [ion binding]; other site
996285004610	short chain dehydrogenase; Provisional; Region: PRK05650
996285004611	classical (c) SDRs; Region: SDR_c; cd05233
996285004612	NAD(P) binding site [chemical binding]; other site
996285004613	active site
996285004614	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
996285004615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285004616	putative substrate translocation pore; other site
996285004617	hypothetical protein; Provisional; Region: PRK00304
996285004618	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
996285004619	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
996285004620	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285004621	dimer interface [polypeptide binding]; other site
996285004622	phosphorylation site [posttranslational modification]
996285004623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285004624	ATP binding site [chemical binding]; other site
996285004625	Mg2+ binding site [ion binding]; other site
996285004626	G-X-G motif; other site
996285004627	Response regulator receiver domain; Region: Response_reg; pfam00072
996285004628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285004629	active site
996285004630	phosphorylation site [posttranslational modification]
996285004631	intermolecular recognition site; other site
996285004632	dimerization interface [polypeptide binding]; other site
996285004633	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
996285004634	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
996285004635	putative oligomer interface [polypeptide binding]; other site
996285004636	putative active site [active]
996285004637	metal binding site [ion binding]; metal-binding site
996285004638	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
996285004639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285004640	Coenzyme A binding pocket [chemical binding]; other site
996285004641	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996285004642	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
996285004643	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
996285004644	active site
996285004645	dimer interface [polypeptide binding]; other site
996285004646	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
996285004647	Ligand Binding Site [chemical binding]; other site
996285004648	Molecular Tunnel; other site
996285004649	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
996285004650	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
996285004651	active site
996285004652	catalytic residues [active]
996285004653	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
996285004654	Methyltransferase domain; Region: Methyltransf_25; pfam13649
996285004655	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
996285004656	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
996285004657	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
996285004658	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
996285004659	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
996285004660	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285004661	NAD(P) binding site [chemical binding]; other site
996285004662	active site
996285004663	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
996285004664	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285004665	ATP binding site [chemical binding]; other site
996285004666	putative Mg++ binding site [ion binding]; other site
996285004667	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285004668	nucleotide binding region [chemical binding]; other site
996285004669	ATP-binding site [chemical binding]; other site
996285004670	DEAD/H associated; Region: DEAD_assoc; pfam08494
996285004671	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
996285004672	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285004673	RNA binding surface [nucleotide binding]; other site
996285004674	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
996285004675	active site
996285004676	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
996285004677	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
996285004678	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
996285004679	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
996285004680	Trp docking motif [polypeptide binding]; other site
996285004681	putative active site [active]
996285004682	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
996285004683	S1 domain; Region: S1_2; pfam13509
996285004684	S1 domain; Region: S1_2; pfam13509
996285004685	Protein of unknown function, DUF488; Region: DUF488; pfam04343
996285004686	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
996285004687	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
996285004688	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
996285004689	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
996285004690	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
996285004691	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
996285004692	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285004693	ATP binding site [chemical binding]; other site
996285004694	putative Mg++ binding site [ion binding]; other site
996285004695	HNH endonuclease; Region: HNH_2; pfam13391
996285004696	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
996285004697	HsdM N-terminal domain; Region: HsdM_N; pfam12161
996285004698	Methyltransferase domain; Region: Methyltransf_26; pfam13659
996285004699	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
996285004700	Fic/DOC family; Region: Fic; cl00960
996285004701	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
996285004702	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
996285004703	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
996285004704	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
996285004705	Protein of unknown function DUF91; Region: DUF91; cl00709
996285004706	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
996285004707	Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377
996285004708	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285004709	ligand binding site [chemical binding]; other site
996285004710	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
996285004711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285004712	ATP binding site [chemical binding]; other site
996285004713	putative Mg++ binding site [ion binding]; other site
996285004714	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285004715	nucleotide binding region [chemical binding]; other site
996285004716	ATP-binding site [chemical binding]; other site
996285004717	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
996285004718	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
996285004719	active site
996285004720	metal binding site [ion binding]; metal-binding site
996285004721	interdomain interaction site; other site
996285004722	Helix-turn-helix domain; Region: HTH_17; pfam12728
996285004723	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285004724	active site
996285004725	DNA binding site [nucleotide binding]
996285004726	Int/Topo IB signature motif; other site
996285004727	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
996285004728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285004729	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285004730	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285004731	Cupin domain; Region: Cupin_2; cl17218
996285004732	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285004733	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285004734	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
996285004735	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
996285004736	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285004737	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285004738	metal binding site [ion binding]; metal-binding site
996285004739	active site
996285004740	I-site; other site
996285004741	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
996285004742	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285004743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285004744	active site
996285004745	phosphorylation site [posttranslational modification]
996285004746	intermolecular recognition site; other site
996285004747	dimerization interface [polypeptide binding]; other site
996285004748	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285004749	DNA binding residues [nucleotide binding]
996285004750	dimerization interface [polypeptide binding]; other site
996285004751	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
996285004752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285004753	dimer interface [polypeptide binding]; other site
996285004754	phosphorylation site [posttranslational modification]
996285004755	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
996285004756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285004757	ATP binding site [chemical binding]; other site
996285004758	Mg2+ binding site [ion binding]; other site
996285004759	G-X-G motif; other site
996285004760	Response regulator receiver domain; Region: Response_reg; pfam00072
996285004761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285004762	active site
996285004763	phosphorylation site [posttranslational modification]
996285004764	intermolecular recognition site; other site
996285004765	dimerization interface [polypeptide binding]; other site
996285004766	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
996285004767	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
996285004768	putative ligand binding site [chemical binding]; other site
996285004769	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285004770	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
996285004771	TM-ABC transporter signature motif; other site
996285004772	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
996285004773	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
996285004774	TM-ABC transporter signature motif; other site
996285004775	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
996285004776	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
996285004777	Walker A/P-loop; other site
996285004778	ATP binding site [chemical binding]; other site
996285004779	Q-loop/lid; other site
996285004780	ABC transporter signature motif; other site
996285004781	Walker B; other site
996285004782	D-loop; other site
996285004783	H-loop/switch region; other site
996285004784	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
996285004785	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
996285004786	Walker A/P-loop; other site
996285004787	ATP binding site [chemical binding]; other site
996285004788	Q-loop/lid; other site
996285004789	ABC transporter signature motif; other site
996285004790	Walker B; other site
996285004791	D-loop; other site
996285004792	H-loop/switch region; other site
996285004793	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
996285004794	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
996285004795	Protein of unknown function (DUF1178); Region: DUF1178; cl17833
996285004796	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
996285004797	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
996285004798	multimer interface [polypeptide binding]; other site
996285004799	active site
996285004800	catalytic triad [active]
996285004801	dimer interface [polypeptide binding]; other site
996285004802	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
996285004803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285004804	Walker A motif; other site
996285004805	ATP binding site [chemical binding]; other site
996285004806	Walker B motif; other site
996285004807	arginine finger; other site
996285004808	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996285004809	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
996285004810	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285004811	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
996285004812	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
996285004813	Predicted deacetylase [General function prediction only]; Region: COG3233
996285004814	putative active site [active]
996285004815	putative Zn binding site [ion binding]; other site
996285004816	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
996285004817	CsbD-like; Region: CsbD; pfam05532
996285004818	Ferredoxin [Energy production and conversion]; Region: COG1146
996285004819	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
996285004820	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
996285004821	MutS domain I; Region: MutS_I; pfam01624
996285004822	MutS domain II; Region: MutS_II; pfam05188
996285004823	MutS domain III; Region: MutS_III; pfam05192
996285004824	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
996285004825	Walker A/P-loop; other site
996285004826	ATP binding site [chemical binding]; other site
996285004827	Q-loop/lid; other site
996285004828	ABC transporter signature motif; other site
996285004829	Walker B; other site
996285004830	D-loop; other site
996285004831	H-loop/switch region; other site
996285004832	Acyltransferase family; Region: Acyl_transf_3; pfam01757
996285004833	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
996285004834	recombinase A; Provisional; Region: recA; PRK09354
996285004835	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
996285004836	hexamer interface [polypeptide binding]; other site
996285004837	Walker A motif; other site
996285004838	ATP binding site [chemical binding]; other site
996285004839	Walker B motif; other site
996285004840	recombination regulator RecX; Reviewed; Region: recX; PRK00117
996285004841	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
996285004842	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
996285004843	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996285004844	Beta-Casp domain; Region: Beta-Casp; smart01027
996285004845	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
996285004846	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
996285004847	XFP N-terminal domain; Region: XFP_N; pfam09364
996285004848	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
996285004849	Uncharacterized conserved protein [Function unknown]; Region: COG3148
996285004850	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
996285004851	EamA-like transporter family; Region: EamA; pfam00892
996285004852	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285004853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285004854	active site
996285004855	phosphorylation site [posttranslational modification]
996285004856	intermolecular recognition site; other site
996285004857	dimerization interface [polypeptide binding]; other site
996285004858	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285004859	DNA binding residues [nucleotide binding]
996285004860	dimerization interface [polypeptide binding]; other site
996285004861	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
996285004862	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285004863	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
996285004864	putative dimerization interface [polypeptide binding]; other site
996285004865	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
996285004866	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
996285004867	FAD binding pocket [chemical binding]; other site
996285004868	FAD binding motif [chemical binding]; other site
996285004869	phosphate binding motif [ion binding]; other site
996285004870	beta-alpha-beta structure motif; other site
996285004871	NAD binding pocket [chemical binding]; other site
996285004872	hypothetical protein; Provisional; Region: PRK00183
996285004873	SEC-C motif; Region: SEC-C; pfam02810
996285004874	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285004875	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285004876	ligand binding site [chemical binding]; other site
996285004877	Predicted integral membrane protein [Function unknown]; Region: COG5615
996285004878	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
996285004879	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996285004880	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
996285004881	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
996285004882	Beta-lactamase; Region: Beta-lactamase; pfam00144
996285004883	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285004884	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285004885	ligand binding site [chemical binding]; other site
996285004886	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
996285004887	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
996285004888	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
996285004889	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
996285004890	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
996285004891	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996285004892	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
996285004893	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996285004894	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
996285004895	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
996285004896	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996285004897	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
996285004898	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
996285004899	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
996285004900	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
996285004901	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996285004902	metal binding triad; other site
996285004903	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
996285004904	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996285004905	Zn2+ binding site [ion binding]; other site
996285004906	Mg2+ binding site [ion binding]; other site
996285004907	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
996285004908	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
996285004909	methionine aminopeptidase; Provisional; Region: PRK08671
996285004910	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
996285004911	active site
996285004912	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
996285004913	rRNA interaction site [nucleotide binding]; other site
996285004914	S8 interaction site; other site
996285004915	putative laminin-1 binding site; other site
996285004916	elongation factor Ts; Provisional; Region: tsf; PRK09377
996285004917	UBA/TS-N domain; Region: UBA; pfam00627
996285004918	Elongation factor TS; Region: EF_TS; pfam00889
996285004919	Elongation factor TS; Region: EF_TS; pfam00889
996285004920	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
996285004921	putative nucleotide binding site [chemical binding]; other site
996285004922	uridine monophosphate binding site [chemical binding]; other site
996285004923	homohexameric interface [polypeptide binding]; other site
996285004924	ribosome recycling factor; Reviewed; Region: frr; PRK00083
996285004925	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
996285004926	hinge region; other site
996285004927	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
996285004928	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
996285004929	catalytic residue [active]
996285004930	putative FPP diphosphate  binding site; other site
996285004931	putative FPP binding hydrophobic cleft; other site
996285004932	dimer interface [polypeptide binding]; other site
996285004933	putative IPP diphosphate binding site; other site
996285004934	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
996285004935	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
996285004936	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
996285004937	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
996285004938	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
996285004939	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
996285004940	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
996285004941	active site
996285004942	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
996285004943	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
996285004944	protein binding site [polypeptide binding]; other site
996285004945	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
996285004946	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
996285004947	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
996285004948	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
996285004949	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
996285004950	Surface antigen; Region: Bac_surface_Ag; pfam01103
996285004951	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
996285004952	periplasmic chaperone; Provisional; Region: PRK10780
996285004953	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
996285004954	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
996285004955	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
996285004956	trimer interface [polypeptide binding]; other site
996285004957	active site
996285004958	UDP-GlcNAc binding site [chemical binding]; other site
996285004959	lipid binding site [chemical binding]; lipid-binding site
996285004960	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
996285004961	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
996285004962	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
996285004963	active site
996285004964	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
996285004965	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
996285004966	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
996285004967	RNA/DNA hybrid binding site [nucleotide binding]; other site
996285004968	active site
996285004969	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
996285004970	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
996285004971	putative active site [active]
996285004972	putative PHP Thumb interface [polypeptide binding]; other site
996285004973	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
996285004974	generic binding surface II; other site
996285004975	generic binding surface I; other site
996285004976	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
996285004977	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
996285004978	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
996285004979	Ligand Binding Site [chemical binding]; other site
996285004980	TilS substrate binding domain; Region: TilS; pfam09179
996285004981	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
996285004982	CTP synthetase; Validated; Region: pyrG; PRK05380
996285004983	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
996285004984	Catalytic site [active]
996285004985	active site
996285004986	UTP binding site [chemical binding]; other site
996285004987	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
996285004988	active site
996285004989	putative oxyanion hole; other site
996285004990	catalytic triad [active]
996285004991	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
996285004992	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
996285004993	enolase; Provisional; Region: eno; PRK00077
996285004994	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
996285004995	dimer interface [polypeptide binding]; other site
996285004996	metal binding site [ion binding]; metal-binding site
996285004997	substrate binding pocket [chemical binding]; other site
996285004998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285004999	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285005000	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
996285005001	Septum formation initiator; Region: DivIC; cl17659
996285005002	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
996285005003	substrate binding site; other site
996285005004	dimer interface; other site
996285005005	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
996285005006	30S subunit binding site; other site
996285005007	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285005008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005009	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
996285005010	putative effector binding pocket; other site
996285005011	putative dimerization interface [polypeptide binding]; other site
996285005012	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
996285005013	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
996285005014	substrate binding site [chemical binding]; other site
996285005015	catalytic Zn binding site [ion binding]; other site
996285005016	NAD binding site [chemical binding]; other site
996285005017	structural Zn binding site [ion binding]; other site
996285005018	dimer interface [polypeptide binding]; other site
996285005019	S-formylglutathione hydrolase; Region: PLN02442
996285005020	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
996285005021	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
996285005022	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
996285005023	FMN binding site [chemical binding]; other site
996285005024	active site
996285005025	substrate binding site [chemical binding]; other site
996285005026	catalytic residue [active]
996285005027	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285005028	dimerization interface [polypeptide binding]; other site
996285005029	putative DNA binding site [nucleotide binding]; other site
996285005030	putative Zn2+ binding site [ion binding]; other site
996285005031	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
996285005032	homotrimer interaction site [polypeptide binding]; other site
996285005033	zinc binding site [ion binding]; other site
996285005034	CDP-binding sites; other site
996285005035	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
996285005036	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
996285005037	Permutation of conserved domain; other site
996285005038	active site
996285005039	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
996285005040	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
996285005041	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
996285005042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285005043	S-adenosylmethionine binding site [chemical binding]; other site
996285005044	Domain of unknown function (DUF368); Region: DUF368; pfam04018
996285005045	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
996285005046	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285005047	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285005048	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
996285005049	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
996285005050	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285005051	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
996285005052	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285005053	DNA binding residues [nucleotide binding]
996285005054	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285005055	Coenzyme A binding pocket [chemical binding]; other site
996285005056	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
996285005057	nudix motif; other site
996285005058	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
996285005059	Na binding site [ion binding]; other site
996285005060	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
996285005061	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
996285005062	active site
996285005063	dimerization interface [polypeptide binding]; other site
996285005064	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
996285005065	heme-binding site [chemical binding]; other site
996285005066	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285005067	Ligand Binding Site [chemical binding]; other site
996285005068	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
996285005069	active site
996285005070	hypothetical protein; Provisional; Region: PRK12378
996285005071	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
996285005072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
996285005073	MOSC domain; Region: MOSC; pfam03473
996285005074	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
996285005075	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996285005076	Zn2+ binding site [ion binding]; other site
996285005077	Mg2+ binding site [ion binding]; other site
996285005078	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
996285005079	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
996285005080	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
996285005081	putative ligand binding site [chemical binding]; other site
996285005082	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
996285005083	NAD binding site [chemical binding]; other site
996285005084	dimerization interface [polypeptide binding]; other site
996285005085	catalytic site [active]
996285005086	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
996285005087	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
996285005088	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996285005089	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
996285005090	active site
996285005091	dimerization interface [polypeptide binding]; other site
996285005092	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
996285005093	30S subunit binding site; other site
996285005094	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
996285005095	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
996285005096	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
996285005097	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285005098	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285005099	dimer interface [polypeptide binding]; other site
996285005100	putative CheW interface [polypeptide binding]; other site
996285005101	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
996285005102	PBP superfamily domain; Region: PBP_like_2; cl17296
996285005103	macrolide transporter subunit MacA; Provisional; Region: PRK11578
996285005104	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
996285005105	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
996285005106	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
996285005107	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
996285005108	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285005109	putative DNA binding site [nucleotide binding]; other site
996285005110	putative Zn2+ binding site [ion binding]; other site
996285005111	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
996285005112	glycerol kinase; Provisional; Region: glpK; PRK00047
996285005113	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
996285005114	N- and C-terminal domain interface [polypeptide binding]; other site
996285005115	active site
996285005116	MgATP binding site [chemical binding]; other site
996285005117	catalytic site [active]
996285005118	metal binding site [ion binding]; metal-binding site
996285005119	glycerol binding site [chemical binding]; other site
996285005120	homotetramer interface [polypeptide binding]; other site
996285005121	homodimer interface [polypeptide binding]; other site
996285005122	FBP binding site [chemical binding]; other site
996285005123	protein IIAGlc interface [polypeptide binding]; other site
996285005124	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
996285005125	amphipathic channel; other site
996285005126	Asn-Pro-Ala signature motifs; other site
996285005127	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
996285005128	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285005129	ATP binding site [chemical binding]; other site
996285005130	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
996285005131	putative Mg++ binding site [ion binding]; other site
996285005132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285005133	nucleotide binding region [chemical binding]; other site
996285005134	ATP-binding site [chemical binding]; other site
996285005135	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
996285005136	Ion transport protein; Region: Ion_trans; pfam00520
996285005137	Ion channel; Region: Ion_trans_2; pfam07885
996285005138	Protein of unknown function DUF72; Region: DUF72; pfam01904
996285005139	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
996285005140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285005141	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285005142	Cytochrome c; Region: Cytochrom_C; pfam00034
996285005143	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
996285005144	homotrimer interaction site [polypeptide binding]; other site
996285005145	putative active site [active]
996285005146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285005147	putative arabinose transporter; Provisional; Region: PRK03545
996285005148	putative substrate translocation pore; other site
996285005149	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
996285005150	Peptidase family U32; Region: Peptidase_U32; pfam01136
996285005151	Collagenase; Region: DUF3656; pfam12392
996285005152	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
996285005153	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996285005154	DNA binding residues [nucleotide binding]
996285005155	putative dimer interface [polypeptide binding]; other site
996285005156	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
996285005157	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
996285005158	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
996285005159	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
996285005160	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
996285005161	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
996285005162	metal binding site [ion binding]; metal-binding site
996285005163	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
996285005164	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
996285005165	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
996285005166	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
996285005167	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
996285005168	DNA binding residues [nucleotide binding]
996285005169	dimer interface [polypeptide binding]; other site
996285005170	putative metal binding site [ion binding]; other site
996285005171	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
996285005172	Strictosidine synthase; Region: Str_synth; pfam03088
996285005173	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
996285005174	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
996285005175	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
996285005176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285005177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005178	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
996285005179	putative substrate binding pocket [chemical binding]; other site
996285005180	putative dimerization interface [polypeptide binding]; other site
996285005181	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
996285005182	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996285005183	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
996285005184	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
996285005185	dimer interface [polypeptide binding]; other site
996285005186	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
996285005187	active site
996285005188	heme binding site [chemical binding]; other site
996285005189	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
996285005190	Methyltransferase domain; Region: Methyltransf_25; pfam13649
996285005191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285005192	Coenzyme A binding pocket [chemical binding]; other site
996285005193	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
996285005194	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
996285005195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005196	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
996285005197	dimerization interface [polypeptide binding]; other site
996285005198	substrate binding pocket [chemical binding]; other site
996285005199	Restriction endonuclease; Region: Mrr_cat; pfam04471
996285005200	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
996285005201	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
996285005202	dimer interface [polypeptide binding]; other site
996285005203	putative radical transfer pathway; other site
996285005204	diiron center [ion binding]; other site
996285005205	tyrosyl radical; other site
996285005206	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
996285005207	ATP cone domain; Region: ATP-cone; pfam03477
996285005208	ATP cone domain; Region: ATP-cone; pfam03477
996285005209	Class I ribonucleotide reductase; Region: RNR_I; cd01679
996285005210	active site
996285005211	dimer interface [polypeptide binding]; other site
996285005212	catalytic residues [active]
996285005213	effector binding site; other site
996285005214	R2 peptide binding site; other site
996285005215	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285005216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285005217	active site
996285005218	phosphorylation site [posttranslational modification]
996285005219	intermolecular recognition site; other site
996285005220	dimerization interface [polypeptide binding]; other site
996285005221	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285005222	DNA binding site [nucleotide binding]
996285005223	sensor protein RstB; Provisional; Region: PRK10604
996285005224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285005225	dimerization interface [polypeptide binding]; other site
996285005226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285005227	dimer interface [polypeptide binding]; other site
996285005228	phosphorylation site [posttranslational modification]
996285005229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285005230	ATP binding site [chemical binding]; other site
996285005231	Mg2+ binding site [ion binding]; other site
996285005232	G-X-G motif; other site
996285005233	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
996285005234	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
996285005235	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
996285005236	active site
996285005237	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
996285005238	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996285005239	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285005240	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
996285005241	active site residue [active]
996285005242	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
996285005243	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
996285005244	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
996285005245	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996285005246	Zn2+ binding site [ion binding]; other site
996285005247	Mg2+ binding site [ion binding]; other site
996285005248	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
996285005249	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285005250	substrate binding site [chemical binding]; other site
996285005251	oxyanion hole (OAH) forming residues; other site
996285005252	trimer interface [polypeptide binding]; other site
996285005253	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
996285005254	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285005255	inhibitor-cofactor binding pocket; inhibition site
996285005256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285005257	catalytic residue [active]
996285005258	succinylglutamate desuccinylase; Provisional; Region: PRK05324
996285005259	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
996285005260	active site
996285005261	Zn binding site [ion binding]; other site
996285005262	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996285005263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285005264	Walker A/P-loop; other site
996285005265	ATP binding site [chemical binding]; other site
996285005266	Q-loop/lid; other site
996285005267	ABC transporter signature motif; other site
996285005268	Walker B; other site
996285005269	D-loop; other site
996285005270	H-loop/switch region; other site
996285005271	inner membrane transport permease; Provisional; Region: PRK15066
996285005272	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
996285005273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
996285005274	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
996285005275	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
996285005276	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
996285005277	VacJ like lipoprotein; Region: VacJ; cl01073
996285005278	PilZ domain; Region: PilZ; pfam07238
996285005279	Response regulator receiver domain; Region: Response_reg; pfam00072
996285005280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285005281	active site
996285005282	phosphorylation site [posttranslational modification]
996285005283	intermolecular recognition site; other site
996285005284	dimerization interface [polypeptide binding]; other site
996285005285	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
996285005286	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
996285005287	anti sigma factor interaction site; other site
996285005288	regulatory phosphorylation site [posttranslational modification]; other site
996285005289	transaldolase-like protein; Provisional; Region: PTZ00411
996285005290	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
996285005291	active site
996285005292	dimer interface [polypeptide binding]; other site
996285005293	catalytic residue [active]
996285005294	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
996285005295	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
996285005296	FMN binding site [chemical binding]; other site
996285005297	active site
996285005298	catalytic residues [active]
996285005299	substrate binding site [chemical binding]; other site
996285005300	DctM-like transporters; Region: DctM; pfam06808
996285005301	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
996285005302	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
996285005303	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285005304	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
996285005305	Tannase and feruloyl esterase; Region: Tannase; pfam07519
996285005306	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
996285005307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285005308	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285005309	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285005310	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
996285005311	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
996285005312	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
996285005313	putative alpha subunit interface [polypeptide binding]; other site
996285005314	putative active site [active]
996285005315	putative substrate binding site [chemical binding]; other site
996285005316	Fe binding site [ion binding]; other site
996285005317	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
996285005318	inter-subunit interface; other site
996285005319	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
996285005320	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285005321	catalytic loop [active]
996285005322	iron binding site [ion binding]; other site
996285005323	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
996285005324	FAD binding pocket [chemical binding]; other site
996285005325	FAD binding motif [chemical binding]; other site
996285005326	phosphate binding motif [ion binding]; other site
996285005327	beta-alpha-beta structure motif; other site
996285005328	NAD binding pocket [chemical binding]; other site
996285005329	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
996285005330	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
996285005331	putative NAD(P) binding site [chemical binding]; other site
996285005332	active site
996285005333	benzoate transport; Region: 2A0115; TIGR00895
996285005334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285005335	putative substrate translocation pore; other site
996285005336	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
996285005337	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
996285005338	octamer interface [polypeptide binding]; other site
996285005339	active site
996285005340	Muconolactone delta-isomerase; Region: MIase; cl01992
996285005341	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
996285005342	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
996285005343	dimer interface [polypeptide binding]; other site
996285005344	active site
996285005345	Benzoate membrane transport protein; Region: BenE; pfam03594
996285005346	benzoate transporter; Region: benE; TIGR00843
996285005347	outer membrane porin, OprD family; Region: OprD; pfam03573
996285005348	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
996285005349	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
996285005350	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
996285005351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285005352	PAS domain; Region: PAS_9; pfam13426
996285005353	putative active site [active]
996285005354	heme pocket [chemical binding]; other site
996285005355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285005356	dimer interface [polypeptide binding]; other site
996285005357	phosphorylation site [posttranslational modification]
996285005358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285005359	ATP binding site [chemical binding]; other site
996285005360	Mg2+ binding site [ion binding]; other site
996285005361	G-X-G motif; other site
996285005362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285005363	active site
996285005364	phosphorylation site [posttranslational modification]
996285005365	intermolecular recognition site; other site
996285005366	dimerization interface [polypeptide binding]; other site
996285005367	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
996285005368	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
996285005369	mercuric reductase; Validated; Region: PRK06370
996285005370	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285005371	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996285005372	fumarate hydratase; Provisional; Region: PRK12425
996285005373	Class II fumarases; Region: Fumarase_classII; cd01362
996285005374	active site
996285005375	tetramer interface [polypeptide binding]; other site
996285005376	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
996285005377	BolA-like protein; Region: BolA; pfam01722
996285005378	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
996285005379	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
996285005380	active site residue [active]
996285005381	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
996285005382	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
996285005383	catalytic residues [active]
996285005384	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
996285005385	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996285005386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285005387	Walker A/P-loop; other site
996285005388	ATP binding site [chemical binding]; other site
996285005389	Q-loop/lid; other site
996285005390	ABC transporter signature motif; other site
996285005391	Walker B; other site
996285005392	D-loop; other site
996285005393	H-loop/switch region; other site
996285005394	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285005395	dimerization interface [polypeptide binding]; other site
996285005396	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285005397	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285005398	dimer interface [polypeptide binding]; other site
996285005399	putative CheW interface [polypeptide binding]; other site
996285005400	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
996285005401	hypothetical protein; Provisional; Region: PRK09256
996285005402	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
996285005403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285005404	putative substrate translocation pore; other site
996285005405	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
996285005406	Predicted membrane protein [Function unknown]; Region: COG4325
996285005407	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285005408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005409	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
996285005410	putative dimerization interface [polypeptide binding]; other site
996285005411	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
996285005412	Uncharacterized conserved protein [Function unknown]; Region: COG3777
996285005413	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
996285005414	active site 2 [active]
996285005415	active site 1 [active]
996285005416	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285005417	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285005418	active site
996285005419	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
996285005420	dimer interface [polypeptide binding]; other site
996285005421	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285005422	metal binding site [ion binding]; metal-binding site
996285005423	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
996285005424	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
996285005425	CoA-transferase family III; Region: CoA_transf_3; pfam02515
996285005426	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
996285005427	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285005428	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285005429	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
996285005430	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
996285005431	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
996285005432	active site
996285005433	catalytic residues [active]
996285005434	metal binding site [ion binding]; metal-binding site
996285005435	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
996285005436	CoA-transferase family III; Region: CoA_transf_3; pfam02515
996285005437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285005438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005439	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
996285005440	putative dimerization interface [polypeptide binding]; other site
996285005441	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285005442	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285005443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285005444	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285005445	Predicted membrane protein [Function unknown]; Region: COG4325
996285005446	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
996285005447	acetyl-CoA synthetase; Provisional; Region: PRK00174
996285005448	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
996285005449	active site
996285005450	CoA binding site [chemical binding]; other site
996285005451	acyl-activating enzyme (AAE) consensus motif; other site
996285005452	AMP binding site [chemical binding]; other site
996285005453	acetate binding site [chemical binding]; other site
996285005454	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
996285005455	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996285005456	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
996285005457	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285005458	substrate binding site [chemical binding]; other site
996285005459	oxyanion hole (OAH) forming residues; other site
996285005460	trimer interface [polypeptide binding]; other site
996285005461	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
996285005462	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
996285005463	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
996285005464	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
996285005465	dimer interface [polypeptide binding]; other site
996285005466	active site
996285005467	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
996285005468	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
996285005469	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
996285005470	active site
996285005471	interdomain interaction site; other site
996285005472	putative metal-binding site [ion binding]; other site
996285005473	nucleotide binding site [chemical binding]; other site
996285005474	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
996285005475	domain I; other site
996285005476	DNA binding groove [nucleotide binding]
996285005477	phosphate binding site [ion binding]; other site
996285005478	domain II; other site
996285005479	domain III; other site
996285005480	nucleotide binding site [chemical binding]; other site
996285005481	catalytic site [active]
996285005482	domain IV; other site
996285005483	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
996285005484	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
996285005485	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
996285005486	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
996285005487	Cell division inhibitor SulA; Region: SulA; cl01880
996285005488	LexA repressor; Validated; Region: PRK00215
996285005489	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
996285005490	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
996285005491	Catalytic site [active]
996285005492	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285005493	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285005494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
996285005495	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
996285005496	beta-hexosaminidase; Provisional; Region: PRK05337
996285005497	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
996285005498	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
996285005499	LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608
996285005500	Water Stress and Hypersensitive response; Region: WHy; smart00769
996285005501	SEC-C motif; Region: SEC-C; pfam02810
996285005502	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
996285005503	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
996285005504	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
996285005505	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
996285005506	active site
996285005507	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
996285005508	homodimer interaction site [polypeptide binding]; other site
996285005509	cofactor binding site; other site
996285005510	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
996285005511	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
996285005512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285005513	catalytic residue [active]
996285005514	BCCT family transporter; Region: BCCT; cl00569
996285005515	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
996285005516	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
996285005517	NAD(P) binding site [chemical binding]; other site
996285005518	catalytic residues [active]
996285005519	choline dehydrogenase; Validated; Region: PRK02106
996285005520	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
996285005521	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
996285005522	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
996285005523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285005524	FeS/SAM binding site; other site
996285005525	Acyltransferase family; Region: Acyl_transf_3; pfam01757
996285005526	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
996285005527	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996285005528	active site
996285005529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285005530	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
996285005531	putative ADP-binding pocket [chemical binding]; other site
996285005532	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285005533	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
996285005534	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285005535	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
996285005536	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
996285005537	transcriptional activator RfaH; Region: RfaH; TIGR01955
996285005538	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
996285005539	heterodimer interface [polypeptide binding]; other site
996285005540	homodimer interface [polypeptide binding]; other site
996285005541	WbqC-like protein family; Region: WbqC; pfam08889
996285005542	tyrosine kinase; Provisional; Region: PRK11519
996285005543	Chain length determinant protein; Region: Wzz; pfam02706
996285005544	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
996285005545	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996285005546	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
996285005547	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996285005548	active site
996285005549	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
996285005550	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
996285005551	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
996285005552	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
996285005553	inhibitor-cofactor binding pocket; inhibition site
996285005554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285005555	catalytic residue [active]
996285005556	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
996285005557	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
996285005558	FMN binding site [chemical binding]; other site
996285005559	active site
996285005560	catalytic residues [active]
996285005561	substrate binding site [chemical binding]; other site
996285005562	short chain dehydrogenase; Provisional; Region: PRK06123
996285005563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285005564	NAD(P) binding site [chemical binding]; other site
996285005565	active site
996285005566	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
996285005567	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
996285005568	putative dimer interface [polypeptide binding]; other site
996285005569	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285005570	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005571	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
996285005572	dimerization interface [polypeptide binding]; other site
996285005573	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
996285005574	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
996285005575	substrate binding site [chemical binding]; other site
996285005576	ligand binding site [chemical binding]; other site
996285005577	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
996285005578	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
996285005579	substrate binding site [chemical binding]; other site
996285005580	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
996285005581	tartrate dehydrogenase; Region: TTC; TIGR02089
996285005582	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
996285005583	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
996285005584	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
996285005585	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
996285005586	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285005587	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
996285005588	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
996285005589	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
996285005590	dimerization interface 3.5A [polypeptide binding]; other site
996285005591	active site
996285005592	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
996285005593	active site
996285005594	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
996285005595	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
996285005596	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
996285005597	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996285005598	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
996285005599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
996285005600	Sporulation related domain; Region: SPOR; pfam05036
996285005601	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
996285005602	Colicin V production protein; Region: Colicin_V; cl00567
996285005603	amidophosphoribosyltransferase; Provisional; Region: PRK09246
996285005604	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
996285005605	active site
996285005606	tetramer interface [polypeptide binding]; other site
996285005607	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285005608	active site
996285005609	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
996285005610	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
996285005611	homodimer interface [polypeptide binding]; other site
996285005612	substrate-cofactor binding pocket; other site
996285005613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285005614	catalytic residue [active]
996285005615	type II secretion system protein D; Region: type_II_gspD; TIGR02517
996285005616	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
996285005617	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
996285005618	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
996285005619	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
996285005620	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
996285005621	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
996285005622	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
996285005623	DNA binding residues [nucleotide binding]
996285005624	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285005625	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
996285005626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285005627	Coenzyme A binding pocket [chemical binding]; other site
996285005628	Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960
996285005629	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
996285005630	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
996285005631	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
996285005632	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
996285005633	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
996285005634	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285005635	N-terminal plug; other site
996285005636	ligand-binding site [chemical binding]; other site
996285005637	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
996285005638	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
996285005639	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
996285005640	tetramer interface [polypeptide binding]; other site
996285005641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285005642	catalytic residue [active]
996285005643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285005644	salt bridge; other site
996285005645	non-specific DNA binding site [nucleotide binding]; other site
996285005646	sequence-specific DNA binding site [nucleotide binding]; other site
996285005647	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
996285005648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285005649	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
996285005650	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
996285005651	DNA binding residues [nucleotide binding]
996285005652	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
996285005653	substrate-cofactor binding pocket; other site
996285005654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285005655	catalytic residue [active]
996285005656	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285005657	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285005658	dimerization interface [polypeptide binding]; other site
996285005659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285005660	dimer interface [polypeptide binding]; other site
996285005661	phosphorylation site [posttranslational modification]
996285005662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285005663	ATP binding site [chemical binding]; other site
996285005664	Mg2+ binding site [ion binding]; other site
996285005665	G-X-G motif; other site
996285005666	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
996285005667	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
996285005668	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
996285005669	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285005670	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
996285005671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285005672	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
996285005673	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
996285005674	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
996285005675	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
996285005676	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285005677	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285005678	dimerization interface [polypeptide binding]; other site
996285005679	LysR substrate binding domain; Region: LysR_substrate; pfam03466
996285005680	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
996285005681	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996285005682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285005683	putative substrate translocation pore; other site
996285005684	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285005685	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
996285005686	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
996285005687	tetramer interface [polypeptide binding]; other site
996285005688	active site
996285005689	Mg2+/Mn2+ binding site [ion binding]; other site
996285005690	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
996285005691	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285005692	putative active site [active]
996285005693	heme pocket [chemical binding]; other site
996285005694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285005695	putative active site [active]
996285005696	heme pocket [chemical binding]; other site
996285005697	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285005698	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285005699	metal binding site [ion binding]; metal-binding site
996285005700	active site
996285005701	I-site; other site
996285005702	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285005703	potential frameshift: common BLAST hit: gi|339493780|ref|YP_004714073.1| thermolysin metallopeptidase
996285005704	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
996285005705	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
996285005706	Zn binding site [ion binding]; other site
996285005707	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
996285005708	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
996285005709	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
996285005710	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
996285005711	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
996285005712	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285005713	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285005714	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
996285005715	active site
996285005716	catalytic triad [active]
996285005717	dimer interface [polypeptide binding]; other site
996285005718	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
996285005719	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
996285005720	active site
996285005721	FMN binding site [chemical binding]; other site
996285005722	2,4-decadienoyl-CoA binding site; other site
996285005723	catalytic residue [active]
996285005724	4Fe-4S cluster binding site [ion binding]; other site
996285005725	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
996285005726	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285005727	SnoaL-like domain; Region: SnoaL_2; pfam12680
996285005728	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
996285005729	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
996285005730	catalytic residue [active]
996285005731	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
996285005732	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
996285005733	ligand binding site [chemical binding]; other site
996285005734	flexible hinge region; other site
996285005735	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
996285005736	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285005737	ligand binding site [chemical binding]; other site
996285005738	flexible hinge region; other site
996285005739	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
996285005740	active site residue [active]
996285005741	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
996285005742	multidrug efflux protein; Reviewed; Region: PRK01766
996285005743	cation binding site [ion binding]; other site
996285005744	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
996285005745	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
996285005746	ligand binding site [chemical binding]; other site
996285005747	NAD binding site [chemical binding]; other site
996285005748	catalytic site [active]
996285005749	homodimer interface [polypeptide binding]; other site
996285005750	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
996285005751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285005752	Walker A motif; other site
996285005753	ATP binding site [chemical binding]; other site
996285005754	Walker B motif; other site
996285005755	arginine finger; other site
996285005756	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
996285005757	hypothetical protein; Validated; Region: PRK00153
996285005758	recombination protein RecR; Reviewed; Region: recR; PRK00076
996285005759	RecR protein; Region: RecR; pfam02132
996285005760	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
996285005761	putative active site [active]
996285005762	putative metal-binding site [ion binding]; other site
996285005763	tetramer interface [polypeptide binding]; other site
996285005764	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285005765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285005766	substrate binding pocket [chemical binding]; other site
996285005767	membrane-bound complex binding site; other site
996285005768	hinge residues; other site
996285005769	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
996285005770	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
996285005771	Walker A/P-loop; other site
996285005772	ATP binding site [chemical binding]; other site
996285005773	Q-loop/lid; other site
996285005774	ABC transporter signature motif; other site
996285005775	Walker B; other site
996285005776	D-loop; other site
996285005777	H-loop/switch region; other site
996285005778	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285005779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285005780	dimer interface [polypeptide binding]; other site
996285005781	conserved gate region; other site
996285005782	putative PBP binding loops; other site
996285005783	ABC-ATPase subunit interface; other site
996285005784	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
996285005785	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
996285005786	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
996285005787	Cu(I) binding site [ion binding]; other site
996285005788	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285005789	active site
996285005790	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
996285005791	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285005792	ligand binding site [chemical binding]; other site
996285005793	flexible hinge region; other site
996285005794	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
996285005795	putative switch regulator; other site
996285005796	non-specific DNA interactions [nucleotide binding]; other site
996285005797	DNA binding site [nucleotide binding]
996285005798	sequence specific DNA binding site [nucleotide binding]; other site
996285005799	putative cAMP binding site [chemical binding]; other site
996285005800	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
996285005801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285005802	FeS/SAM binding site; other site
996285005803	HemN C-terminal domain; Region: HemN_C; pfam06969
996285005804	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
996285005805	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
996285005806	homodimer interface [polypeptide binding]; other site
996285005807	NAD binding pocket [chemical binding]; other site
996285005808	ATP binding pocket [chemical binding]; other site
996285005809	Mg binding site [ion binding]; other site
996285005810	active-site loop [active]
996285005811	Uncharacterized conserved protein [Function unknown]; Region: COG2836
996285005812	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
996285005813	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
996285005814	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
996285005815	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285005816	metal-binding site [ion binding]
996285005817	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285005818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
996285005819	FixH; Region: FixH; pfam05751
996285005820	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
996285005821	4Fe-4S binding domain; Region: Fer4_5; pfam12801
996285005822	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
996285005823	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
996285005824	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285005825	Cytochrome c; Region: Cytochrom_C; pfam00034
996285005826	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
996285005827	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
996285005828	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
996285005829	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
996285005830	Putative water exit pathway; other site
996285005831	Binuclear center (active site) [active]
996285005832	Putative proton exit pathway; other site
996285005833	Low-spin heme binding site [chemical binding]; other site
996285005834	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
996285005835	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285005836	Cytochrome c; Region: Cytochrom_C; pfam00034
996285005837	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
996285005838	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
996285005839	potential frameshift: common BLAST hit: gi|146282206|ref|YP_001172359.1| cytochrome c oxidase, cbb3-type subunit I
996285005840	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
996285005841	Putative water exit pathway; other site
996285005842	Putative proton exit pathway; other site
996285005843	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
996285005844	D-pathway; other site
996285005845	K-pathway; other site
996285005846	Binuclear center (active site) [active]
996285005847	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
996285005848	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285005849	PAS domain; Region: PAS_9; pfam13426
996285005850	putative active site [active]
996285005851	heme pocket [chemical binding]; other site
996285005852	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285005853	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285005854	dimer interface [polypeptide binding]; other site
996285005855	putative CheW interface [polypeptide binding]; other site
996285005856	aconitate hydratase; Validated; Region: PRK09277
996285005857	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
996285005858	substrate binding site [chemical binding]; other site
996285005859	ligand binding site [chemical binding]; other site
996285005860	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
996285005861	substrate binding site [chemical binding]; other site
996285005862	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
996285005863	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
996285005864	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
996285005865	CPxP  motif; other site
996285005866	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
996285005867	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
996285005868	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
996285005869	D-pathway; other site
996285005870	Putative ubiquinol binding site [chemical binding]; other site
996285005871	Low-spin heme (heme b) binding site [chemical binding]; other site
996285005872	Putative water exit pathway; other site
996285005873	Binuclear center (heme o3/CuB) [ion binding]; other site
996285005874	K-pathway; other site
996285005875	Putative proton exit pathway; other site
996285005876	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
996285005877	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
996285005878	Cytochrome c; Region: Cytochrom_C; pfam00034
996285005879	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
996285005880	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
996285005881	Ion transport protein; Region: Ion_trans; pfam00520
996285005882	Ion channel; Region: Ion_trans_2; pfam07885
996285005883	Double zinc ribbon; Region: DZR; pfam12773
996285005884	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
996285005885	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
996285005886	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285005887	FeS/SAM binding site; other site
996285005888	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
996285005889	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
996285005890	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
996285005891	Walker A/P-loop; other site
996285005892	ATP binding site [chemical binding]; other site
996285005893	Q-loop/lid; other site
996285005894	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
996285005895	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
996285005896	ABC transporter signature motif; other site
996285005897	Walker B; other site
996285005898	D-loop; other site
996285005899	H-loop/switch region; other site
996285005900	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
996285005901	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
996285005902	FtsZ protein binding site [polypeptide binding]; other site
996285005903	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
996285005904	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
996285005905	nucleotide binding pocket [chemical binding]; other site
996285005906	K-X-D-G motif; other site
996285005907	catalytic site [active]
996285005908	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
996285005909	Protein of unknown function, DUF484; Region: DUF484; cl17449
996285005910	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
996285005911	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
996285005912	Dimer interface [polypeptide binding]; other site
996285005913	flagellin; Provisional; Region: PRK12806
996285005914	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
996285005915	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
996285005916	FlaG protein; Region: FlaG; pfam03646
996285005917	potential frameshift: common BLAST hit: gi|339493839|ref|YP_004714132.1| flagellar capping protein FliD
996285005918	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
996285005919	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
996285005920	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
996285005921	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
996285005922	flagellar protein FliS; Validated; Region: fliS; PRK05685
996285005923	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
996285005924	Protein of unknown function, DUF486; Region: DUF486; pfam04342
996285005925	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
996285005926	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
996285005927	dimer interface [polypeptide binding]; other site
996285005928	active site
996285005929	citrylCoA binding site [chemical binding]; other site
996285005930	NADH binding [chemical binding]; other site
996285005931	cationic pore residues; other site
996285005932	oxalacetate/citrate binding site [chemical binding]; other site
996285005933	coenzyme A binding site [chemical binding]; other site
996285005934	catalytic triad [active]
996285005935	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
996285005936	SdhD (CybS) interface [polypeptide binding]; other site
996285005937	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
996285005938	SdhC subunit interface [polypeptide binding]; other site
996285005939	proximal heme binding site [chemical binding]; other site
996285005940	cardiolipin binding site; other site
996285005941	Iron-sulfur protein interface; other site
996285005942	proximal quinone binding site [chemical binding]; other site
996285005943	L-aspartate oxidase; Provisional; Region: PRK06175
996285005944	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
996285005945	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
996285005946	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
996285005947	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
996285005948	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
996285005949	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
996285005950	TPP-binding site [chemical binding]; other site
996285005951	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
996285005952	PYR/PP interface [polypeptide binding]; other site
996285005953	dimer interface [polypeptide binding]; other site
996285005954	TPP binding site [chemical binding]; other site
996285005955	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
996285005956	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285005957	E3 interaction surface; other site
996285005958	lipoyl attachment site [posttranslational modification]; other site
996285005959	e3 binding domain; Region: E3_binding; pfam02817
996285005960	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
996285005961	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
996285005962	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
996285005963	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285005964	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996285005965	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
996285005966	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
996285005967	CoA-ligase; Region: Ligase_CoA; pfam00549
996285005968	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
996285005969	CoA binding domain; Region: CoA_binding; smart00881
996285005970	CoA-ligase; Region: Ligase_CoA; pfam00549
996285005971	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
996285005972	Predicted membrane protein [Function unknown]; Region: COG3821
996285005973	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996285005974	CoenzymeA binding site [chemical binding]; other site
996285005975	subunit interaction site [polypeptide binding]; other site
996285005976	PHB binding site; other site
996285005977	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996285005978	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
996285005979	CoenzymeA binding site [chemical binding]; other site
996285005980	subunit interaction site [polypeptide binding]; other site
996285005981	PHB binding site; other site
996285005982	heat shock protein 90; Provisional; Region: PRK05218
996285005983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285005984	ATP binding site [chemical binding]; other site
996285005985	Mg2+ binding site [ion binding]; other site
996285005986	G-X-G motif; other site
996285005987	OsmC-like protein; Region: OsmC; pfam02566
996285005988	Amidohydrolase; Region: Amidohydro_2; pfam04909
996285005989	Domain of unknown function (DUF3859); Region: DUF3859; pfam12975
996285005990	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
996285005991	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285005992	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285005993	dimerization interface [polypeptide binding]; other site
996285005994	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285005995	dimer interface [polypeptide binding]; other site
996285005996	putative CheW interface [polypeptide binding]; other site
996285005997	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
996285005998	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285005999	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285006000	dimer interface [polypeptide binding]; other site
996285006001	putative CheW interface [polypeptide binding]; other site
996285006002	serine/threonine transporter SstT; Provisional; Region: PRK13628
996285006003	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
996285006004	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
996285006005	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
996285006006	dimer interface [polypeptide binding]; other site
996285006007	active site
996285006008	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
996285006009	active site 1 [active]
996285006010	dimer interface [polypeptide binding]; other site
996285006011	active site 2 [active]
996285006012	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
996285006013	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
996285006014	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
996285006015	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
996285006016	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996285006017	catalytic core [active]
996285006018	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
996285006019	CoenzymeA binding site [chemical binding]; other site
996285006020	subunit interaction site [polypeptide binding]; other site
996285006021	PHB binding site; other site
996285006022	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
996285006023	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
996285006024	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
996285006025	Domain of unknown function DUF20; Region: UPF0118; pfam01594
996285006026	hypothetical protein; Provisional; Region: PRK10279
996285006027	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
996285006028	active site
996285006029	nucleophile elbow; other site
996285006030	selenophosphate synthetase; Provisional; Region: PRK00943
996285006031	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
996285006032	dimerization interface [polypeptide binding]; other site
996285006033	putative ATP binding site [chemical binding]; other site
996285006034	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
996285006035	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
996285006036	active site residue [active]
996285006037	MoxR-like ATPases [General function prediction only]; Region: COG0714
996285006038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285006039	Walker A motif; other site
996285006040	ATP binding site [chemical binding]; other site
996285006041	Walker B motif; other site
996285006042	arginine finger; other site
996285006043	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
996285006044	Protein of unknown function DUF58; Region: DUF58; pfam01882
996285006045	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
996285006046	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
996285006047	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
996285006048	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
996285006049	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
996285006050	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
996285006051	active site
996285006052	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
996285006053	active site 2 [active]
996285006054	Predicted membrane protein [Function unknown]; Region: COG1238
996285006055	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
996285006056	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285006057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285006058	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
996285006059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285006060	NAD(P) binding site [chemical binding]; other site
996285006061	active site
996285006062	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
996285006063	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
996285006064	dimer interface [polypeptide binding]; other site
996285006065	active site
996285006066	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285006067	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285006068	active site
996285006069	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
996285006070	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
996285006071	dimer interface [polypeptide binding]; other site
996285006072	acyl-activating enzyme (AAE) consensus motif; other site
996285006073	putative active site [active]
996285006074	AMP binding site [chemical binding]; other site
996285006075	putative CoA binding site [chemical binding]; other site
996285006076	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
996285006077	CoA-transferase family III; Region: CoA_transf_3; pfam02515
996285006078	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285006079	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285006080	active site
996285006081	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
996285006082	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285006083	substrate binding site [chemical binding]; other site
996285006084	oxyanion hole (OAH) forming residues; other site
996285006085	trimer interface [polypeptide binding]; other site
996285006086	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
996285006087	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996285006088	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
996285006089	enoyl-CoA hydratase; Provisional; Region: PRK05862
996285006090	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285006091	substrate binding site [chemical binding]; other site
996285006092	oxyanion hole (OAH) forming residues; other site
996285006093	trimer interface [polypeptide binding]; other site
996285006094	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
996285006095	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
996285006096	tetrameric interface [polypeptide binding]; other site
996285006097	NAD binding site [chemical binding]; other site
996285006098	catalytic residues [active]
996285006099	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285006100	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285006101	LysR substrate binding domain; Region: LysR_substrate; pfam03466
996285006102	dimerization interface [polypeptide binding]; other site
996285006103	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
996285006104	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
996285006105	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285006106	Soluble P-type ATPase [General function prediction only]; Region: COG4087
996285006107	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
996285006108	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
996285006109	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
996285006110	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
996285006111	Ligand Binding Site [chemical binding]; other site
996285006112	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
996285006113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285006114	dimer interface [polypeptide binding]; other site
996285006115	phosphorylation site [posttranslational modification]
996285006116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285006117	ATP binding site [chemical binding]; other site
996285006118	Mg2+ binding site [ion binding]; other site
996285006119	G-X-G motif; other site
996285006120	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
996285006121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285006122	active site
996285006123	phosphorylation site [posttranslational modification]
996285006124	intermolecular recognition site; other site
996285006125	dimerization interface [polypeptide binding]; other site
996285006126	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285006127	DNA binding site [nucleotide binding]
996285006128	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
996285006129	putative homodimer interface [polypeptide binding]; other site
996285006130	putative active site pocket [active]
996285006131	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
996285006132	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
996285006133	putative catalytic site [active]
996285006134	putative metal binding site [ion binding]; other site
996285006135	putative phosphate binding site [ion binding]; other site
996285006136	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
996285006137	Transglycosylase; Region: Transgly; pfam00912
996285006138	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
996285006139	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
996285006140	Helix-turn-helix domain; Region: HTH_18; pfam12833
996285006141	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285006142	AzlC protein; Region: AzlC; pfam03591
996285006143	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
996285006144	Bacterial SH3 domain; Region: SH3_3; pfam08239
996285006145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006146	PAS fold; Region: PAS_3; pfam08447
996285006147	putative active site [active]
996285006148	heme pocket [chemical binding]; other site
996285006149	PAS domain S-box; Region: sensory_box; TIGR00229
996285006150	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006151	putative active site [active]
996285006152	heme pocket [chemical binding]; other site
996285006153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285006154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285006155	ATP binding site [chemical binding]; other site
996285006156	Mg2+ binding site [ion binding]; other site
996285006157	G-X-G motif; other site
996285006158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285006159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285006160	active site
996285006161	phosphorylation site [posttranslational modification]
996285006162	intermolecular recognition site; other site
996285006163	dimerization interface [polypeptide binding]; other site
996285006164	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
996285006165	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
996285006166	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
996285006167	TrkA-N domain; Region: TrkA_N; pfam02254
996285006168	TrkA-C domain; Region: TrkA_C; pfam02080
996285006169	Uncharacterized conserved protein [Function unknown]; Region: COG3791
996285006170	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
996285006171	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
996285006172	putative molybdopterin cofactor binding site [chemical binding]; other site
996285006173	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
996285006174	putative molybdopterin cofactor binding site; other site
996285006175	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
996285006176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285006177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285006178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
996285006179	dimerization interface [polypeptide binding]; other site
996285006180	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
996285006181	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285006182	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285006183	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285006184	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285006185	metal binding site [ion binding]; metal-binding site
996285006186	active site
996285006187	I-site; other site
996285006188	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
996285006189	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
996285006190	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285006191	Phytase; Region: Phytase; cl17685
996285006192	Phytase; Region: Phytase; cl17685
996285006193	TolQ protein; Region: tolQ; TIGR02796
996285006194	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
996285006195	TolR protein; Region: tolR; TIGR02801
996285006196	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
996285006197	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
996285006198	PAS domain; Region: PAS_9; pfam13426
996285006199	PAS fold; Region: PAS_4; pfam08448
996285006200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006201	putative active site [active]
996285006202	heme pocket [chemical binding]; other site
996285006203	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285006204	GAF domain; Region: GAF; pfam01590
996285006205	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
996285006206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285006207	dimer interface [polypeptide binding]; other site
996285006208	phosphorylation site [posttranslational modification]
996285006209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285006210	ATP binding site [chemical binding]; other site
996285006211	G-X-G motif; other site
996285006212	Response regulator receiver domain; Region: Response_reg; pfam00072
996285006213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285006214	active site
996285006215	phosphorylation site [posttranslational modification]
996285006216	intermolecular recognition site; other site
996285006217	dimerization interface [polypeptide binding]; other site
996285006218	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
996285006219	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
996285006220	Family description; Region: UvrD_C_2; pfam13538
996285006221	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
996285006222	Protein phosphatase 2C; Region: PP2C; pfam00481
996285006223	active site
996285006224	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996285006225	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996285006226	active site
996285006227	ATP binding site [chemical binding]; other site
996285006228	substrate binding site [chemical binding]; other site
996285006229	activation loop (A-loop); other site
996285006230	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
996285006231	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
996285006232	nitrite reductase subunit NirD; Provisional; Region: PRK14989
996285006233	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285006234	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
996285006235	NAD-dependent deacetylase; Provisional; Region: PRK00481
996285006236	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
996285006237	NAD+ binding site [chemical binding]; other site
996285006238	substrate binding site [chemical binding]; other site
996285006239	Zn binding site [ion binding]; other site
996285006240	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
996285006241	HemN C-terminal domain; Region: HemN_C; pfam06969
996285006242	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285006243	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285006244	dimer interface [polypeptide binding]; other site
996285006245	putative CheW interface [polypeptide binding]; other site
996285006246	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
996285006247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285006248	S-adenosylmethionine binding site [chemical binding]; other site
996285006249	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
996285006250	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
996285006251	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285006252	short chain dehydrogenase; Provisional; Region: PRK06101
996285006253	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285006254	NAD(P) binding site [chemical binding]; other site
996285006255	active site
996285006256	SnoaL-like domain; Region: SnoaL_2; pfam12680
996285006257	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
996285006258	DNA photolyase; Region: DNA_photolyase; pfam00875
996285006259	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
996285006260	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
996285006261	DNA binding residues [nucleotide binding]
996285006262	B12 binding domain; Region: B12-binding_2; pfam02607
996285006263	Protein of unknown function (DUF523); Region: DUF523; pfam04463
996285006264	Uncharacterized conserved protein [Function unknown]; Region: COG3272
996285006265	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
996285006266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285006267	TIGR01777 family protein; Region: yfcH
996285006268	NAD(P) binding site [chemical binding]; other site
996285006269	active site
996285006270	ferrochelatase; Reviewed; Region: hemH; PRK00035
996285006271	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
996285006272	C-terminal domain interface [polypeptide binding]; other site
996285006273	active site
996285006274	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
996285006275	active site
996285006276	N-terminal domain interface [polypeptide binding]; other site
996285006277	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
996285006278	PAS fold; Region: PAS_4; pfam08448
996285006279	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006280	putative active site [active]
996285006281	heme pocket [chemical binding]; other site
996285006282	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006283	PAS domain; Region: PAS_9; pfam13426
996285006284	putative active site [active]
996285006285	heme pocket [chemical binding]; other site
996285006286	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285006287	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285006288	metal binding site [ion binding]; metal-binding site
996285006289	active site
996285006290	I-site; other site
996285006291	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285006292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006293	PAS domain; Region: PAS_9; pfam13426
996285006294	putative active site [active]
996285006295	heme pocket [chemical binding]; other site
996285006296	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
996285006297	MFS/sugar transport protein; Region: MFS_2; pfam13347
996285006298	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245
996285006299	active site
996285006300	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
996285006301	homodecamer interface [polypeptide binding]; other site
996285006302	GTP cyclohydrolase I; Provisional; Region: PLN03044
996285006303	active site
996285006304	putative catalytic site residues [active]
996285006305	zinc binding site [ion binding]; other site
996285006306	GTP-CH-I/GFRP interaction surface; other site
996285006307	Protein of unknown function, DUF393; Region: DUF393; pfam04134
996285006308	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996285006309	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
996285006310	DNA binding residues [nucleotide binding]
996285006311	B12 binding domain; Region: B12-binding_2; pfam02607
996285006312	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
996285006313	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
996285006314	Gram-negative porin; Region: Porin_4; pfam13609
996285006315	Uncharacterized conserved protein [Function unknown]; Region: COG3287
996285006316	FIST N domain; Region: FIST; pfam08495
996285006317	FIST C domain; Region: FIST_C; pfam10442
996285006318	PAS fold; Region: PAS_7; pfam12860
996285006319	PAS fold; Region: PAS_7; pfam12860
996285006320	PAS domain S-box; Region: sensory_box; TIGR00229
996285006321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006322	putative active site [active]
996285006323	heme pocket [chemical binding]; other site
996285006324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285006325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285006326	dimer interface [polypeptide binding]; other site
996285006327	phosphorylation site [posttranslational modification]
996285006328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285006329	ATP binding site [chemical binding]; other site
996285006330	Mg2+ binding site [ion binding]; other site
996285006331	G-X-G motif; other site
996285006332	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285006333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285006334	active site
996285006335	phosphorylation site [posttranslational modification]
996285006336	intermolecular recognition site; other site
996285006337	dimerization interface [polypeptide binding]; other site
996285006338	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
996285006339	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
996285006340	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
996285006341	putative dimer interface [polypeptide binding]; other site
996285006342	N-terminal domain interface [polypeptide binding]; other site
996285006343	putative substrate binding pocket (H-site) [chemical binding]; other site
996285006344	hypothetical protein; Validated; Region: PRK09071
996285006345	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
996285006346	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
996285006347	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
996285006348	DsrC like protein; Region: DsrC; cl01101
996285006349	DsrH like protein; Region: DsrH; cl17347
996285006350	sulfur relay protein TusC; Validated; Region: PRK00211
996285006351	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
996285006352	enterobactin exporter EntS; Provisional; Region: PRK10489
996285006353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285006354	putative substrate translocation pore; other site
996285006355	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
996285006356	YccA-like proteins; Region: YccA_like; cd10433
996285006357	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
996285006358	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
996285006359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285006360	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
996285006361	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
996285006362	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
996285006363	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
996285006364	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
996285006365	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
996285006366	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
996285006367	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
996285006368	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
996285006369	Walker A/P-loop; other site
996285006370	ATP binding site [chemical binding]; other site
996285006371	Q-loop/lid; other site
996285006372	ABC transporter signature motif; other site
996285006373	Walker B; other site
996285006374	D-loop; other site
996285006375	H-loop/switch region; other site
996285006376	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285006377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285006378	dimer interface [polypeptide binding]; other site
996285006379	conserved gate region; other site
996285006380	putative PBP binding loops; other site
996285006381	ABC-ATPase subunit interface; other site
996285006382	Isochorismatase family; Region: Isochorismatase; pfam00857
996285006383	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
996285006384	catalytic triad [active]
996285006385	conserved cis-peptide bond; other site
996285006386	Creatinine amidohydrolase; Region: Creatininase; pfam02633
996285006387	EamA-like transporter family; Region: EamA; pfam00892
996285006388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285006389	NAD(P) binding site [chemical binding]; other site
996285006390	active site
996285006391	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
996285006392	classical (c) SDRs; Region: SDR_c; cd05233
996285006393	NAD(P) binding site [chemical binding]; other site
996285006394	active site
996285006395	Fatty acid desaturase; Region: FA_desaturase; pfam00487
996285006396	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
996285006397	putative di-iron ligands [ion binding]; other site
996285006398	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285006399	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
996285006400	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996285006401	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996285006402	active site
996285006403	catalytic tetrad [active]
996285006404	allophanate hydrolase; Provisional; Region: PRK08186
996285006405	Amidase; Region: Amidase; cl11426
996285006406	urea carboxylase; Region: urea_carbox; TIGR02712
996285006407	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996285006408	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996285006409	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
996285006410	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
996285006411	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
996285006412	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996285006413	carboxyltransferase (CT) interaction site; other site
996285006414	biotinylation site [posttranslational modification]; other site
996285006415	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
996285006416	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
996285006417	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
996285006418	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
996285006419	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
996285006420	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
996285006421	Walker A/P-loop; other site
996285006422	ATP binding site [chemical binding]; other site
996285006423	Q-loop/lid; other site
996285006424	ABC transporter signature motif; other site
996285006425	Walker B; other site
996285006426	D-loop; other site
996285006427	H-loop/switch region; other site
996285006428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
996285006429	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285006430	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285006431	dimerization interface [polypeptide binding]; other site
996285006432	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285006433	dimer interface [polypeptide binding]; other site
996285006434	putative CheW interface [polypeptide binding]; other site
996285006435	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
996285006436	active site
996285006437	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285006438	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
996285006439	substrate binding pocket [chemical binding]; other site
996285006440	membrane-bound complex binding site; other site
996285006441	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
996285006442	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285006443	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285006444	catalytic residue [active]
996285006445	lipase chaperone; Provisional; Region: PRK01294
996285006446	Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224
996285006447	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
996285006448	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
996285006449	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
996285006450	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
996285006451	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
996285006452	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
996285006453	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996285006454	Walker A/P-loop; other site
996285006455	ATP binding site [chemical binding]; other site
996285006456	Q-loop/lid; other site
996285006457	ABC transporter signature motif; other site
996285006458	Walker B; other site
996285006459	D-loop; other site
996285006460	H-loop/switch region; other site
996285006461	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
996285006462	active site
996285006463	catalytic triad [active]
996285006464	oxyanion hole [active]
996285006465	switch loop; other site
996285006466	L,D-transpeptidase; Provisional; Region: PRK10260
996285006467	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
996285006468	Predicted acetyltransferase [General function prediction only]; Region: COG2388
996285006469	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
996285006470	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
996285006471	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
996285006472	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
996285006473	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
996285006474	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
996285006475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285006476	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
996285006477	substrate binding site [chemical binding]; other site
996285006478	dimerization interface [polypeptide binding]; other site
996285006479	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
996285006480	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
996285006481	Active Sites [active]
996285006482	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
996285006483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285006484	motif II; other site
996285006485	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
996285006486	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
996285006487	chorismate binding enzyme; Region: Chorismate_bind; cl10555
996285006488	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
996285006489	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
996285006490	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
996285006491	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
996285006492	Transcriptional regulators [Transcription]; Region: GntR; COG1802
996285006493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285006494	DNA-binding site [nucleotide binding]; DNA binding site
996285006495	FCD domain; Region: FCD; pfam07729
996285006496	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
996285006497	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
996285006498	tetramer interface [polypeptide binding]; other site
996285006499	active site
996285006500	Mg2+/Mn2+ binding site [ion binding]; other site
996285006501	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
996285006502	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
996285006503	dimer interface [polypeptide binding]; other site
996285006504	active site
996285006505	citrylCoA binding site [chemical binding]; other site
996285006506	oxalacetate/citrate binding site [chemical binding]; other site
996285006507	coenzyme A binding site [chemical binding]; other site
996285006508	catalytic triad [active]
996285006509	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
996285006510	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
996285006511	substrate binding site [chemical binding]; other site
996285006512	ligand binding site [chemical binding]; other site
996285006513	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
996285006514	substrate binding site [chemical binding]; other site
996285006515	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
996285006516	PEP synthetase regulatory protein; Provisional; Region: PRK05339
996285006517	phosphoenolpyruvate synthase; Validated; Region: PRK06464
996285006518	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
996285006519	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
996285006520	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
996285006521	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
996285006522	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
996285006523	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
996285006524	Cl binding site [ion binding]; other site
996285006525	oligomer interface [polypeptide binding]; other site
996285006526	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996285006527	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285006528	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
996285006529	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285006530	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285006531	DNA binding residues [nucleotide binding]
996285006532	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
996285006533	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285006534	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285006535	ligand binding site [chemical binding]; other site
996285006536	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
996285006537	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
996285006538	substrate binding site [chemical binding]; other site
996285006539	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
996285006540	substrate binding site [chemical binding]; other site
996285006541	ligand binding site [chemical binding]; other site
996285006542	Predicted Fe-S protein [General function prediction only]; Region: COG3313
996285006543	universal stress protein UspE; Provisional; Region: PRK11175
996285006544	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285006545	Ligand Binding Site [chemical binding]; other site
996285006546	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285006547	Ligand Binding Site [chemical binding]; other site
996285006548	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
996285006549	active site
996285006550	dinuclear metal binding site [ion binding]; other site
996285006551	dimerization interface [polypeptide binding]; other site
996285006552	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
996285006553	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
996285006554	putative active site [active]
996285006555	putative metal binding site [ion binding]; other site
996285006556	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
996285006557	substrate binding site [chemical binding]; other site
996285006558	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
996285006559	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996285006560	active site
996285006561	HIGH motif; other site
996285006562	nucleotide binding site [chemical binding]; other site
996285006563	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
996285006564	KMSKS motif; other site
996285006565	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
996285006566	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
996285006567	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
996285006568	active site
996285006569	HIGH motif; other site
996285006570	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
996285006571	KMSKS motif; other site
996285006572	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
996285006573	tRNA binding surface [nucleotide binding]; other site
996285006574	anticodon binding site; other site
996285006575	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
996285006576	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
996285006577	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
996285006578	homodimer interface [polypeptide binding]; other site
996285006579	NADP binding site [chemical binding]; other site
996285006580	substrate binding site [chemical binding]; other site
996285006581	Transcriptional regulators [Transcription]; Region: FadR; COG2186
996285006582	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285006583	DNA-binding site [nucleotide binding]; DNA binding site
996285006584	FCD domain; Region: FCD; pfam07729
996285006585	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996285006586	trigger factor; Provisional; Region: tig; PRK01490
996285006587	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996285006588	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
996285006589	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
996285006590	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
996285006591	oligomer interface [polypeptide binding]; other site
996285006592	active site residues [active]
996285006593	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
996285006594	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
996285006595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285006596	Walker A motif; other site
996285006597	ATP binding site [chemical binding]; other site
996285006598	Walker B motif; other site
996285006599	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
996285006600	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
996285006601	Found in ATP-dependent protease La (LON); Region: LON; smart00464
996285006602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285006603	Walker A motif; other site
996285006604	ATP binding site [chemical binding]; other site
996285006605	Walker B motif; other site
996285006606	arginine finger; other site
996285006607	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
996285006608	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
996285006609	IHF dimer interface [polypeptide binding]; other site
996285006610	IHF - DNA interface [nucleotide binding]; other site
996285006611	periplasmic folding chaperone; Provisional; Region: PRK10788
996285006612	SurA N-terminal domain; Region: SurA_N_3; pfam13624
996285006613	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
996285006614	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
996285006615	phosphate binding site [ion binding]; other site
996285006616	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
996285006617	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
996285006618	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285006619	catalytic residue [active]
996285006620	Predicted membrane protein [Function unknown]; Region: COG3748
996285006621	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
996285006622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285006623	FeS/SAM binding site; other site
996285006624	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
996285006625	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
996285006626	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
996285006627	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996285006628	NAD(P) binding site [chemical binding]; other site
996285006629	catalytic residues [active]
996285006630	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
996285006631	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
996285006632	active site
996285006633	FMN binding site [chemical binding]; other site
996285006634	substrate binding site [chemical binding]; other site
996285006635	putative catalytic residue [active]
996285006636	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
996285006637	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
996285006638	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
996285006639	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
996285006640	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
996285006641	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285006642	FeS/SAM binding site; other site
996285006643	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
996285006644	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
996285006645	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996285006646	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
996285006647	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
996285006648	putative active site [active]
996285006649	metal binding site [ion binding]; metal-binding site
996285006650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285006651	PAS domain; Region: PAS_9; pfam13426
996285006652	putative active site [active]
996285006653	heme pocket [chemical binding]; other site
996285006654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285006655	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285006656	dimer interface [polypeptide binding]; other site
996285006657	phosphorylation site [posttranslational modification]
996285006658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285006659	ATP binding site [chemical binding]; other site
996285006660	Mg2+ binding site [ion binding]; other site
996285006661	G-X-G motif; other site
996285006662	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285006663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285006664	active site
996285006665	phosphorylation site [posttranslational modification]
996285006666	intermolecular recognition site; other site
996285006667	dimerization interface [polypeptide binding]; other site
996285006668	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
996285006669	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285006670	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
996285006671	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
996285006672	response regulator; Provisional; Region: PRK09483
996285006673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285006674	active site
996285006675	phosphorylation site [posttranslational modification]
996285006676	intermolecular recognition site; other site
996285006677	dimerization interface [polypeptide binding]; other site
996285006678	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285006679	DNA binding residues [nucleotide binding]
996285006680	dimerization interface [polypeptide binding]; other site
996285006681	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
996285006682	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
996285006683	GIY-YIG motif/motif A; other site
996285006684	active site
996285006685	catalytic site [active]
996285006686	putative DNA binding site [nucleotide binding]; other site
996285006687	metal binding site [ion binding]; metal-binding site
996285006688	UvrB/uvrC motif; Region: UVR; pfam02151
996285006689	Glutamate-cysteine ligase; Region: GshA; pfam08886
996285006690	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
996285006691	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
996285006692	DNA binding site [nucleotide binding]
996285006693	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
996285006694	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
996285006695	Predicted permease; Region: DUF318; cl17795
996285006696	Predicted permease; Region: DUF318; cl17795
996285006697	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
996285006698	arsenical-resistance protein; Region: acr3; TIGR00832
996285006699	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
996285006700	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
996285006701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285006702	dimerization interface [polypeptide binding]; other site
996285006703	putative DNA binding site [nucleotide binding]; other site
996285006704	putative Zn2+ binding site [ion binding]; other site
996285006705	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
996285006706	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996285006707	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
996285006708	hypothetical protein; Provisional; Region: PRK02237
996285006709	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
996285006710	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
996285006711	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
996285006712	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285006713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285006714	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285006715	RES domain; Region: RES; smart00953
996285006716	DEAD_2; Region: DEAD_2; pfam06733
996285006717	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
996285006718	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
996285006719	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
996285006720	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
996285006721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285006722	FeS/SAM binding site; other site
996285006723	HemN C-terminal domain; Region: HemN_C; pfam06969
996285006724	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285006725	dimerization interface [polypeptide binding]; other site
996285006726	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285006727	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285006728	dimer interface [polypeptide binding]; other site
996285006729	putative CheW interface [polypeptide binding]; other site
996285006730	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
996285006731	active site
996285006732	tetramer interface; other site
996285006733	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
996285006734	active site
996285006735	glutathione reductase; Validated; Region: PRK06116
996285006736	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285006737	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285006738	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996285006739	Protein of unknown function (DUF461); Region: DUF461; pfam04314
996285006740	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
996285006741	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
996285006742	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285006743	active site
996285006744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
996285006745	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
996285006746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285006747	Fusaric acid resistance protein family; Region: FUSC; pfam04632
996285006748	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
996285006749	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
996285006750	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
996285006751	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285006752	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285006753	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
996285006754	transcriptional regulator; Provisional; Region: PRK10632
996285006755	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285006756	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285006757	putative effector binding pocket; other site
996285006758	dimerization interface [polypeptide binding]; other site
996285006759	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
996285006760	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285006761	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285006762	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285006763	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285006764	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
996285006765	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
996285006766	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
996285006767	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
996285006768	[2Fe-2S] cluster binding site [ion binding]; other site
996285006769	oxidoreductase; Provisional; Region: PRK06128
996285006770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285006771	NAD(P) binding site [chemical binding]; other site
996285006772	active site
996285006773	thiamine pyrophosphate protein; Provisional; Region: PRK08273
996285006774	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
996285006775	PYR/PP interface [polypeptide binding]; other site
996285006776	dimer interface [polypeptide binding]; other site
996285006777	tetramer interface [polypeptide binding]; other site
996285006778	TPP binding site [chemical binding]; other site
996285006779	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
996285006780	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
996285006781	TPP-binding site [chemical binding]; other site
996285006782	potential frameshift: common BLAST hit: gi|146282484|ref|YP_001172637.1| ATP-dependent DNA ligase
996285006783	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
996285006784	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
996285006785	nucleotide binding site [chemical binding]; other site
996285006786	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
996285006787	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
996285006788	active site
996285006789	DNA binding site [nucleotide binding]
996285006790	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
996285006791	DNA binding site [nucleotide binding]
996285006792	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
996285006793	Predicted membrane protein [Function unknown]; Region: COG3205
996285006794	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
996285006795	dinuclear metal binding motif [ion binding]; other site
996285006796	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996285006797	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285006798	Competence-damaged protein; Region: CinA; pfam02464
996285006799	glycogen synthase; Provisional; Region: glgA; PRK00654
996285006800	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
996285006801	ADP-binding pocket [chemical binding]; other site
996285006802	homodimer interface [polypeptide binding]; other site
996285006803	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
996285006804	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
996285006805	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
996285006806	catalytic site [active]
996285006807	active site
996285006808	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
996285006809	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
996285006810	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
996285006811	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
996285006812	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
996285006813	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
996285006814	active site
996285006815	catalytic site [active]
996285006816	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
996285006817	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
996285006818	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
996285006819	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
996285006820	active site
996285006821	catalytic site [active]
996285006822	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
996285006823	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285006824	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
996285006825	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
996285006826	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
996285006827	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
996285006828	putative active site [active]
996285006829	metal binding site [ion binding]; metal-binding site
996285006830	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285006831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285006832	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285006833	putative effector binding pocket; other site
996285006834	dimerization interface [polypeptide binding]; other site
996285006835	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
996285006836	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
996285006837	NAD binding site [chemical binding]; other site
996285006838	catalytic Zn binding site [ion binding]; other site
996285006839	structural Zn binding site [ion binding]; other site
996285006840	Protein of unknown function DUF72; Region: DUF72; pfam01904
996285006841	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
996285006842	putative catalytic site [active]
996285006843	putative metal binding site [ion binding]; other site
996285006844	putative phosphate binding site [ion binding]; other site
996285006845	cardiolipin synthase 2; Provisional; Region: PRK11263
996285006846	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
996285006847	putative active site [active]
996285006848	catalytic site [active]
996285006849	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
996285006850	putative active site [active]
996285006851	catalytic site [active]
996285006852	Predicted integral membrane protein [Function unknown]; Region: COG0392
996285006853	glycogen branching enzyme; Provisional; Region: PRK05402
996285006854	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
996285006855	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
996285006856	active site
996285006857	catalytic site [active]
996285006858	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
996285006859	trehalose synthase; Region: treS_nterm; TIGR02456
996285006860	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
996285006861	active site
996285006862	catalytic site [active]
996285006863	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
996285006864	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
996285006865	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
996285006866	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
996285006867	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
996285006868	active site
996285006869	homodimer interface [polypeptide binding]; other site
996285006870	catalytic site [active]
996285006871	acceptor binding site [chemical binding]; other site
996285006872	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
996285006873	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
996285006874	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
996285006875	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
996285006876	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
996285006877	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
996285006878	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285006879	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285006880	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
996285006881	molybdopterin cofactor binding site; other site
996285006882	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
996285006883	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
996285006884	nucleotide binding site [chemical binding]; other site
996285006885	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
996285006886	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
996285006887	putative DNA binding site [nucleotide binding]; other site
996285006888	putative homodimer interface [polypeptide binding]; other site
996285006889	short chain dehydrogenase; Provisional; Region: PRK06701
996285006890	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
996285006891	NAD binding site [chemical binding]; other site
996285006892	metal binding site [ion binding]; metal-binding site
996285006893	active site
996285006894	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
996285006895	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
996285006896	putative NAD(P) binding site [chemical binding]; other site
996285006897	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285006898	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285006899	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
996285006900	putative substrate binding pocket [chemical binding]; other site
996285006901	putative dimerization interface [polypeptide binding]; other site
996285006902	potential frameshift: common BLAST hit: gi|146282520|ref|YP_001172673.1| RND multidrug efflux membrane fusion protein MexE
996285006903	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
996285006904	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285006905	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285006906	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
996285006907	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
996285006908	aminoglycoside resistance protein; Provisional; Region: PRK13746
996285006909	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
996285006910	active site
996285006911	NTP binding site [chemical binding]; other site
996285006912	metal binding triad [ion binding]; metal-binding site
996285006913	antibiotic binding site [chemical binding]; other site
996285006914	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
996285006915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
996285006916	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285006917	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285006918	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
996285006919	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
996285006920	Protein export membrane protein; Region: SecD_SecF; cl14618
996285006921	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
996285006922	Protein export membrane protein; Region: SecD_SecF; cl14618
996285006923	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
996285006924	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285006925	E3 interaction surface; other site
996285006926	lipoyl attachment site [posttranslational modification]; other site
996285006927	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285006928	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
996285006929	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
996285006930	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
996285006931	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
996285006932	dimer interface [polypeptide binding]; other site
996285006933	catalytic triad [active]
996285006934	peroxidatic and resolving cysteines [active]
996285006935	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
996285006936	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
996285006937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
996285006938	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
996285006939	Family of unknown function (DUF490); Region: DUF490; pfam04357
996285006940	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
996285006941	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
996285006942	Surface antigen; Region: Bac_surface_Ag; pfam01103
996285006943	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
996285006944	Coenzyme A binding pocket [chemical binding]; other site
996285006945	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
996285006946	putative catalytic site [active]
996285006947	putative phosphate binding site [ion binding]; other site
996285006948	active site
996285006949	metal binding site A [ion binding]; metal-binding site
996285006950	DNA binding site [nucleotide binding]
996285006951	putative AP binding site [nucleotide binding]; other site
996285006952	putative metal binding site B [ion binding]; other site
996285006953	PBP superfamily domain; Region: PBP_like_2; cl17296
996285006954	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285006955	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285006956	ligand binding site [chemical binding]; other site
996285006957	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
996285006958	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
996285006959	putative substrate binding site [chemical binding]; other site
996285006960	putative ATP binding site [chemical binding]; other site
996285006961	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
996285006962	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285006963	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285006964	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285006965	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
996285006966	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
996285006967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285006968	dimer interface [polypeptide binding]; other site
996285006969	conserved gate region; other site
996285006970	putative PBP binding loops; other site
996285006971	ABC-ATPase subunit interface; other site
996285006972	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
996285006973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285006974	dimer interface [polypeptide binding]; other site
996285006975	conserved gate region; other site
996285006976	putative PBP binding loops; other site
996285006977	ABC-ATPase subunit interface; other site
996285006978	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
996285006979	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
996285006980	Walker A/P-loop; other site
996285006981	ATP binding site [chemical binding]; other site
996285006982	Q-loop/lid; other site
996285006983	ABC transporter signature motif; other site
996285006984	Walker B; other site
996285006985	D-loop; other site
996285006986	H-loop/switch region; other site
996285006987	TOBE domain; Region: TOBE_2; pfam08402
996285006988	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
996285006989	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
996285006990	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
996285006991	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
996285006992	N- and C-terminal domain interface [polypeptide binding]; other site
996285006993	D-xylulose kinase; Region: XylB; TIGR01312
996285006994	active site
996285006995	MgATP binding site [chemical binding]; other site
996285006996	catalytic site [active]
996285006997	metal binding site [ion binding]; metal-binding site
996285006998	xylulose binding site [chemical binding]; other site
996285006999	putative homodimer interface [polypeptide binding]; other site
996285007000	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
996285007001	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285007002	FAD binding site [chemical binding]; other site
996285007003	substrate binding site [chemical binding]; other site
996285007004	catalytic base [active]
996285007005	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
996285007006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285007007	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
996285007008	substrate binding pocket [chemical binding]; other site
996285007009	dimerization interface [polypeptide binding]; other site
996285007010	Transcriptional regulators [Transcription]; Region: PurR; COG1609
996285007011	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
996285007012	DNA binding site [nucleotide binding]
996285007013	domain linker motif; other site
996285007014	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
996285007015	putative ligand binding site [chemical binding]; other site
996285007016	putative dimerization interface [polypeptide binding]; other site
996285007017	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285007018	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285007019	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
996285007020	DctM-like transporters; Region: DctM; pfam06808
996285007021	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
996285007022	AAA domain; Region: AAA_33; pfam13671
996285007023	ATP-binding site [chemical binding]; other site
996285007024	Gluconate-6-phosphate binding site [chemical binding]; other site
996285007025	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
996285007026	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
996285007027	Predicted ATPase [General function prediction only]; Region: COG1485
996285007028	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
996285007029	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285007030	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285007031	dimerization interface [polypeptide binding]; other site
996285007032	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
996285007033	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285007034	hydroxyglutarate oxidase; Provisional; Region: PRK11728
996285007035	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
996285007036	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
996285007037	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
996285007038	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285007039	N-terminal plug; other site
996285007040	ligand-binding site [chemical binding]; other site
996285007041	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
996285007042	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285007043	Walker A/P-loop; other site
996285007044	ATP binding site [chemical binding]; other site
996285007045	Q-loop/lid; other site
996285007046	ABC transporter signature motif; other site
996285007047	Walker B; other site
996285007048	D-loop; other site
996285007049	H-loop/switch region; other site
996285007050	ABC transporter; Region: ABC_tran_2; pfam12848
996285007051	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285007052	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
996285007053	Cache domain; Region: Cache_2; pfam08269
996285007054	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285007055	dimerization interface [polypeptide binding]; other site
996285007056	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285007057	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285007058	dimer interface [polypeptide binding]; other site
996285007059	putative CheW interface [polypeptide binding]; other site
996285007060	Predicted membrane protein [Function unknown]; Region: COG2323
996285007061	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
996285007062	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
996285007063	active site
996285007064	DNA binding site [nucleotide binding]
996285007065	Int/Topo IB signature motif; other site
996285007066	catalytic residues [active]
996285007067	PAS fold; Region: PAS_4; pfam08448
996285007068	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285007069	putative active site [active]
996285007070	heme pocket [chemical binding]; other site
996285007071	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285007072	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285007073	metal binding site [ion binding]; metal-binding site
996285007074	active site
996285007075	I-site; other site
996285007076	Response regulator receiver domain; Region: Response_reg; pfam00072
996285007077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285007078	active site
996285007079	phosphorylation site [posttranslational modification]
996285007080	intermolecular recognition site; other site
996285007081	dimerization interface [polypeptide binding]; other site
996285007082	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
996285007083	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
996285007084	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
996285007085	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
996285007086	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
996285007087	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
996285007088	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
996285007089	substrate binding pocket [chemical binding]; other site
996285007090	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
996285007091	B12 binding site [chemical binding]; other site
996285007092	cobalt ligand [ion binding]; other site
996285007093	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
996285007094	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
996285007095	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
996285007096	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
996285007097	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
996285007098	AAA domain; Region: AAA_28; pfam13521
996285007099	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
996285007100	EamA-like transporter family; Region: EamA; pfam00892
996285007101	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
996285007102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285007103	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464
996285007104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285007105	FeS/SAM binding site; other site
996285007106	Leucine rich repeat; Region: LRR_8; pfam13855
996285007107	Leucine rich repeat; Region: LRR_8; pfam13855
996285007108	Leucine rich repeat; Region: LRR_8; pfam13855
996285007109	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
996285007110	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996285007111	active site
996285007112	ATP binding site [chemical binding]; other site
996285007113	substrate binding site [chemical binding]; other site
996285007114	activation loop (A-loop); other site
996285007115	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
996285007116	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
996285007117	putative dimer interface [polypeptide binding]; other site
996285007118	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
996285007119	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
996285007120	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
996285007121	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
996285007122	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
996285007123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
996285007124	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
996285007125	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
996285007126	NADP binding site [chemical binding]; other site
996285007127	dimer interface [polypeptide binding]; other site
996285007128	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
996285007129	putative inner membrane peptidase; Provisional; Region: PRK11778
996285007130	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
996285007131	tandem repeat interface [polypeptide binding]; other site
996285007132	oligomer interface [polypeptide binding]; other site
996285007133	active site residues [active]
996285007134	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
996285007135	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
996285007136	catalytic core [active]
996285007137	SCP-2 sterol transfer family; Region: SCP2; pfam02036
996285007138	Phosphotransferase enzyme family; Region: APH; pfam01636
996285007139	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
996285007140	putative active site [active]
996285007141	putative substrate binding site [chemical binding]; other site
996285007142	ATP binding site [chemical binding]; other site
996285007143	short chain dehydrogenase; Provisional; Region: PRK07035
996285007144	classical (c) SDRs; Region: SDR_c; cd05233
996285007145	NAD(P) binding site [chemical binding]; other site
996285007146	active site
996285007147	exoribonuclease R; Provisional; Region: PRK11642
996285007148	hypothetical protein; Provisional; Region: PRK10621
996285007149	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996285007150	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
996285007151	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
996285007152	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
996285007153	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
996285007154	putative NADH binding site [chemical binding]; other site
996285007155	putative active site [active]
996285007156	nudix motif; other site
996285007157	putative metal binding site [ion binding]; other site
996285007158	enoyl-CoA hydratase; Provisional; Region: PRK06142
996285007159	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285007160	substrate binding site [chemical binding]; other site
996285007161	oxyanion hole (OAH) forming residues; other site
996285007162	trimer interface [polypeptide binding]; other site
996285007163	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
996285007164	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
996285007165	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
996285007166	homodimer interface [polypeptide binding]; other site
996285007167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285007168	catalytic residue [active]
996285007169	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
996285007170	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
996285007171	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
996285007172	active site
996285007173	catalytic site [active]
996285007174	substrate binding site [chemical binding]; other site
996285007175	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
996285007176	RNA/DNA hybrid binding site [nucleotide binding]; other site
996285007177	active site
996285007178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285007179	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
996285007180	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285007181	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285007182	catalytic residue [active]
996285007183	Immunoglobulin domain; Region: Ig; cl11960
996285007184	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285007185	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285007186	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285007187	HDOD domain; Region: HDOD; pfam08668
996285007188	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
996285007189	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
996285007190	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
996285007191	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
996285007192	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
996285007193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285007194	dimer interface [polypeptide binding]; other site
996285007195	conserved gate region; other site
996285007196	ABC-ATPase subunit interface; other site
996285007197	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
996285007198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285007199	dimer interface [polypeptide binding]; other site
996285007200	conserved gate region; other site
996285007201	putative PBP binding loops; other site
996285007202	ABC-ATPase subunit interface; other site
996285007203	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
996285007204	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996285007205	Walker A/P-loop; other site
996285007206	ATP binding site [chemical binding]; other site
996285007207	Q-loop/lid; other site
996285007208	ABC transporter signature motif; other site
996285007209	Walker B; other site
996285007210	D-loop; other site
996285007211	H-loop/switch region; other site
996285007212	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996285007213	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
996285007214	Walker A/P-loop; other site
996285007215	ATP binding site [chemical binding]; other site
996285007216	Q-loop/lid; other site
996285007217	ABC transporter signature motif; other site
996285007218	Walker B; other site
996285007219	D-loop; other site
996285007220	H-loop/switch region; other site
996285007221	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
996285007222	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
996285007223	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
996285007224	NAD binding site [chemical binding]; other site
996285007225	homotetramer interface [polypeptide binding]; other site
996285007226	homodimer interface [polypeptide binding]; other site
996285007227	substrate binding site [chemical binding]; other site
996285007228	active site
996285007229	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
996285007230	classical (c) SDRs; Region: SDR_c; cd05233
996285007231	NAD(P) binding site [chemical binding]; other site
996285007232	active site
996285007233	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285007234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285007235	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285007236	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285007237	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
996285007238	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
996285007239	dimer interface [polypeptide binding]; other site
996285007240	Trp docking motif [polypeptide binding]; other site
996285007241	active site
996285007242	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
996285007243	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
996285007244	putative ligand binding site [chemical binding]; other site
996285007245	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996285007246	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
996285007247	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
996285007248	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285007249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285007250	substrate binding pocket [chemical binding]; other site
996285007251	membrane-bound complex binding site; other site
996285007252	hinge residues; other site
996285007253	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285007254	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285007255	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
996285007256	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
996285007257	dimer interface [polypeptide binding]; other site
996285007258	Trp docking motif [polypeptide binding]; other site
996285007259	active site
996285007260	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
996285007261	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
996285007262	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
996285007263	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
996285007264	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
996285007265	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
996285007266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285007267	PAS domain; Region: PAS_9; pfam13426
996285007268	putative active site [active]
996285007269	heme pocket [chemical binding]; other site
996285007270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285007271	PAS domain; Region: PAS_9; pfam13426
996285007272	putative active site [active]
996285007273	heme pocket [chemical binding]; other site
996285007274	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285007275	dimer interface [polypeptide binding]; other site
996285007276	putative CheW interface [polypeptide binding]; other site
996285007277	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
996285007278	active site
996285007279	catalytic site [active]
996285007280	substrate binding site [chemical binding]; other site
996285007281	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
996285007282	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
996285007283	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
996285007284	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285007285	N-terminal plug; other site
996285007286	ligand-binding site [chemical binding]; other site
996285007287	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285007288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285007289	active site
996285007290	phosphorylation site [posttranslational modification]
996285007291	intermolecular recognition site; other site
996285007292	dimerization interface [polypeptide binding]; other site
996285007293	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285007294	DNA binding residues [nucleotide binding]
996285007295	dimerization interface [polypeptide binding]; other site
996285007296	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285007297	dimerization interface [polypeptide binding]; other site
996285007298	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
996285007299	Histidine kinase; Region: HisKA_3; pfam07730
996285007300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285007301	ATP binding site [chemical binding]; other site
996285007302	Mg2+ binding site [ion binding]; other site
996285007303	G-X-G motif; other site
996285007304	Cache domain; Region: Cache_1; pfam02743
996285007305	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285007306	dimerization interface [polypeptide binding]; other site
996285007307	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285007308	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285007309	dimer interface [polypeptide binding]; other site
996285007310	putative CheW interface [polypeptide binding]; other site
996285007311	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
996285007312	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
996285007313	ligand binding site [chemical binding]; other site
996285007314	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
996285007315	Sel1-like repeats; Region: SEL1; smart00671
996285007316	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
996285007317	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
996285007318	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
996285007319	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
996285007320	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285007321	Walker A/P-loop; other site
996285007322	ATP binding site [chemical binding]; other site
996285007323	Q-loop/lid; other site
996285007324	ABC transporter signature motif; other site
996285007325	Walker B; other site
996285007326	D-loop; other site
996285007327	H-loop/switch region; other site
996285007328	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
996285007329	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
996285007330	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
996285007331	active site residue [active]
996285007332	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285007333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285007334	active site
996285007335	phosphorylation site [posttranslational modification]
996285007336	intermolecular recognition site; other site
996285007337	dimerization interface [polypeptide binding]; other site
996285007338	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285007339	DNA binding residues [nucleotide binding]
996285007340	dimerization interface [polypeptide binding]; other site
996285007341	siroheme synthase; Provisional; Region: cysG; PRK10637
996285007342	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
996285007343	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
996285007344	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
996285007345	active site
996285007346	SAM binding site [chemical binding]; other site
996285007347	homodimer interface [polypeptide binding]; other site
996285007348	seryl-tRNA synthetase; Provisional; Region: PRK05431
996285007349	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
996285007350	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
996285007351	dimer interface [polypeptide binding]; other site
996285007352	active site
996285007353	motif 1; other site
996285007354	motif 2; other site
996285007355	motif 3; other site
996285007356	camphor resistance protein CrcB; Provisional; Region: PRK14234
996285007357	recombination factor protein RarA; Reviewed; Region: PRK13342
996285007358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007359	Walker A motif; other site
996285007360	ATP binding site [chemical binding]; other site
996285007361	Walker B motif; other site
996285007362	arginine finger; other site
996285007363	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
996285007364	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
996285007365	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
996285007366	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
996285007367	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
996285007368	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
996285007369	thioredoxin reductase; Provisional; Region: PRK10262
996285007370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285007371	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285007372	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
996285007373	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
996285007374	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
996285007375	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
996285007376	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
996285007377	rRNA binding site [nucleotide binding]; other site
996285007378	predicted 30S ribosome binding site; other site
996285007379	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
996285007380	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007381	Walker A motif; other site
996285007382	ATP binding site [chemical binding]; other site
996285007383	Walker B motif; other site
996285007384	arginine finger; other site
996285007385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007386	Walker A motif; other site
996285007387	ATP binding site [chemical binding]; other site
996285007388	Walker B motif; other site
996285007389	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996285007390	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
996285007391	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996285007392	DNA-binding site [nucleotide binding]; DNA binding site
996285007393	RNA-binding motif; other site
996285007394	isocitrate dehydrogenase; Validated; Region: PRK07362
996285007395	isocitrate dehydrogenase; Reviewed; Region: PRK07006
996285007396	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
996285007397	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
996285007398	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
996285007399	nudix motif; other site
996285007400	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
996285007401	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
996285007402	putative lysogenization regulator; Reviewed; Region: PRK00218
996285007403	adenylosuccinate lyase; Provisional; Region: PRK09285
996285007404	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
996285007405	tetramer interface [polypeptide binding]; other site
996285007406	active site
996285007407	Uncharacterized conserved protein [Function unknown]; Region: COG2850
996285007408	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
996285007409	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285007410	Coenzyme A binding pocket [chemical binding]; other site
996285007411	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
996285007412	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
996285007413	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
996285007414	tetramer interface [polypeptide binding]; other site
996285007415	active site
996285007416	Mg2+/Mn2+ binding site [ion binding]; other site
996285007417	isocitrate lyase; Region: PLN02892
996285007418	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
996285007419	Domain of unknown function DUF20; Region: UPF0118; pfam01594
996285007420	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
996285007421	Predicted permease [General function prediction only]; Region: COG2056
996285007422	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
996285007423	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
996285007424	active site
996285007425	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
996285007426	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
996285007427	active site
996285007428	putative substrate binding pocket [chemical binding]; other site
996285007429	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
996285007430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285007431	S-adenosylmethionine binding site [chemical binding]; other site
996285007432	phosphoglycolate phosphatase; Provisional; Region: PRK13222
996285007433	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
996285007434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285007435	motif II; other site
996285007436	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
996285007437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285007438	NAD(P) binding site [chemical binding]; other site
996285007439	active site
996285007440	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
996285007441	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285007442	RNA binding surface [nucleotide binding]; other site
996285007443	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
996285007444	probable active site [active]
996285007445	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
996285007446	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
996285007447	active site
996285007448	intersubunit interface [polypeptide binding]; other site
996285007449	catalytic residue [active]
996285007450	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
996285007451	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
996285007452	putative active site [active]
996285007453	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
996285007454	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
996285007455	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
996285007456	HemK family putative methylases; Region: hemK_fam; TIGR00536
996285007457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285007458	S-adenosylmethionine binding site [chemical binding]; other site
996285007459	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
996285007460	Isochorismatase family; Region: Isochorismatase; pfam00857
996285007461	catalytic triad [active]
996285007462	conserved cis-peptide bond; other site
996285007463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
996285007464	Smr domain; Region: Smr; pfam01713
996285007465	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
996285007466	homodecamer interface [polypeptide binding]; other site
996285007467	GTP cyclohydrolase I; Provisional; Region: PLN03044
996285007468	active site
996285007469	putative catalytic site residues [active]
996285007470	zinc binding site [ion binding]; other site
996285007471	GTP-CH-I/GFRP interaction surface; other site
996285007472	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285007473	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
996285007474	putative C-terminal domain interface [polypeptide binding]; other site
996285007475	putative GSH binding site (G-site) [chemical binding]; other site
996285007476	putative dimer interface [polypeptide binding]; other site
996285007477	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
996285007478	N-terminal domain interface [polypeptide binding]; other site
996285007479	dimer interface [polypeptide binding]; other site
996285007480	substrate binding pocket (H-site) [chemical binding]; other site
996285007481	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
996285007482	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285007483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285007484	homodimer interface [polypeptide binding]; other site
996285007485	catalytic residue [active]
996285007486	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
996285007487	MarR family; Region: MarR_2; pfam12802
996285007488	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
996285007489	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
996285007490	RNA binding site [nucleotide binding]; other site
996285007491	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
996285007492	RNA binding site [nucleotide binding]; other site
996285007493	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
996285007494	RNA binding site [nucleotide binding]; other site
996285007495	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
996285007496	RNA binding site [nucleotide binding]; other site
996285007497	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
996285007498	RNA binding site [nucleotide binding]; other site
996285007499	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
996285007500	RNA binding site [nucleotide binding]; other site
996285007501	cytidylate kinase; Provisional; Region: cmk; PRK00023
996285007502	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
996285007503	CMP-binding site; other site
996285007504	The sites determining sugar specificity; other site
996285007505	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
996285007506	prephenate dehydrogenase; Validated; Region: PRK08507
996285007507	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
996285007508	hinge; other site
996285007509	active site
996285007510	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
996285007511	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285007512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285007513	homodimer interface [polypeptide binding]; other site
996285007514	catalytic residue [active]
996285007515	chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807
996285007516	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
996285007517	Prephenate dehydratase; Region: PDT; pfam00800
996285007518	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
996285007519	putative L-Phe binding site [chemical binding]; other site
996285007520	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
996285007521	homodimer interface [polypeptide binding]; other site
996285007522	substrate-cofactor binding pocket; other site
996285007523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285007524	catalytic residue [active]
996285007525	DNA gyrase subunit A; Validated; Region: PRK05560
996285007526	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
996285007527	CAP-like domain; other site
996285007528	active site
996285007529	primary dimer interface [polypeptide binding]; other site
996285007530	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996285007531	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996285007532	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996285007533	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996285007534	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996285007535	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
996285007536	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
996285007537	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
996285007538	Uncharacterized conserved protein [Function unknown]; Region: COG4544
996285007539	DNA Polymerase Y-family; Region: PolY_like; cd03468
996285007540	active site
996285007541	DNA binding site [nucleotide binding]
996285007542	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
996285007543	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
996285007544	putative active site [active]
996285007545	putative PHP Thumb interface [polypeptide binding]; other site
996285007546	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
996285007547	generic binding surface I; other site
996285007548	generic binding surface II; other site
996285007549	D-cysteine desulfhydrase; Validated; Region: PRK03910
996285007550	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
996285007551	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285007552	catalytic residue [active]
996285007553	potential frameshift: common BLAST hit: gi|146282694|ref|YP_001172847.1| cystine transporter subunit
996285007554	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285007555	substrate binding pocket [chemical binding]; other site
996285007556	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285007557	membrane-bound complex binding site; other site
996285007558	hinge residues; other site
996285007559	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996285007560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285007561	dimer interface [polypeptide binding]; other site
996285007562	conserved gate region; other site
996285007563	putative PBP binding loops; other site
996285007564	ABC-ATPase subunit interface; other site
996285007565	potential frameshift: common BLAST hit: gi|146282696|ref|YP_001172849.1| putative amino-acid ABC transporter ATP-binding protein YecC
996285007566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285007567	Walker A/P-loop; other site
996285007568	ATP binding site [chemical binding]; other site
996285007569	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285007570	Q-loop/lid; other site
996285007571	ABC transporter signature motif; other site
996285007572	Walker B; other site
996285007573	D-loop; other site
996285007574	H-loop/switch region; other site
996285007575	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
996285007576	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
996285007577	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
996285007578	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
996285007579	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
996285007580	TrkA-N domain; Region: TrkA_N; pfam02254
996285007581	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
996285007582	potential frameshift: common BLAST hit: gi|146282702|ref|YP_001172855.1| chaperone-associated ATPase
996285007583	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
996285007584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
996285007585	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996285007586	Clp amino terminal domain; Region: Clp_N; pfam02861
996285007587	Clp amino terminal domain; Region: Clp_N; pfam02861
996285007588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007589	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
996285007590	Walker A motif; other site
996285007591	ATP binding site [chemical binding]; other site
996285007592	Walker B motif; other site
996285007593	arginine finger; other site
996285007594	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007595	Walker A motif; other site
996285007596	ATP binding site [chemical binding]; other site
996285007597	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
996285007598	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285007599	Walker A motif; other site
996285007600	ATP binding site [chemical binding]; other site
996285007601	Walker B motif; other site
996285007602	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285007603	Walker A motif; other site
996285007604	ATP binding site [chemical binding]; other site
996285007605	Walker B motif; other site
996285007606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
996285007607	intermolecular recognition site; other site
996285007608	active site
996285007609	dimerization interface [polypeptide binding]; other site
996285007610	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
996285007611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285007612	ABC transporter signature motif; other site
996285007613	Walker B; other site
996285007614	D-loop; other site
996285007615	H-loop/switch region; other site
996285007616	hypothetical protein; Provisional; Region: PRK06850
996285007617	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
996285007618	Active Sites [active]
996285007619	Transposase domain (DUF772); Region: DUF772; pfam05598
996285007620	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285007621	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285007622	hypothetical protein; Reviewed; Region: PRK00024
996285007623	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
996285007624	MPN+ (JAMM) motif; other site
996285007625	Zinc-binding site [ion binding]; other site
996285007626	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
996285007627	Uncharacterized conserved protein [Function unknown]; Region: COG1432
996285007628	putative metal binding site [ion binding]; other site
996285007629	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
996285007630	PAAR motif; Region: PAAR_motif; cl15808
996285007631	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
996285007632	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
996285007633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285007634	non-specific DNA binding site [nucleotide binding]; other site
996285007635	salt bridge; other site
996285007636	sequence-specific DNA binding site [nucleotide binding]; other site
996285007637	HipA-like N-terminal domain; Region: HipA_N; pfam07805
996285007638	HipA-like C-terminal domain; Region: HipA_C; pfam07804
996285007639	Antirestriction protein (ArdA); Region: ArdA; pfam07275
996285007640	Helix-turn-helix domain; Region: HTH_17; pfam12728
996285007641	Replication initiator protein A; Region: RPA; pfam10134
996285007642	ParA-like protein; Provisional; Region: PHA02518
996285007643	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285007644	P-loop; other site
996285007645	Magnesium ion binding site [ion binding]; other site
996285007646	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
996285007647	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
996285007648	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
996285007649	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
996285007650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285007651	salt bridge; other site
996285007652	non-specific DNA binding site [nucleotide binding]; other site
996285007653	sequence-specific DNA binding site [nucleotide binding]; other site
996285007654	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
996285007655	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
996285007656	substrate-cofactor binding pocket; other site
996285007657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285007658	catalytic residue [active]
996285007659	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
996285007660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285007661	Coenzyme A binding pocket [chemical binding]; other site
996285007662	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
996285007663	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
996285007664	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
996285007665	active site
996285007666	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
996285007667	dimer interface [polypeptide binding]; other site
996285007668	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
996285007669	Ligand Binding Site [chemical binding]; other site
996285007670	Molecular Tunnel; other site
996285007671	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
996285007672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285007673	putative substrate translocation pore; other site
996285007674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285007675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285007676	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
996285007677	dimerization interface [polypeptide binding]; other site
996285007678	substrate binding pocket [chemical binding]; other site
996285007679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285007680	non-specific DNA binding site [nucleotide binding]; other site
996285007681	salt bridge; other site
996285007682	sequence-specific DNA binding site [nucleotide binding]; other site
996285007683	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285007684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285007685	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285007686	dimerization interface [polypeptide binding]; other site
996285007687	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
996285007688	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
996285007689	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
996285007690	protein binding site [polypeptide binding]; other site
996285007691	Peptidase family M48; Region: Peptidase_M48; cl12018
996285007692	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
996285007693	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285007694	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285007695	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285007696	putative active site [active]
996285007697	PAS fold; Region: PAS_3; pfam08447
996285007698	heme pocket [chemical binding]; other site
996285007699	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285007700	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285007701	metal binding site [ion binding]; metal-binding site
996285007702	active site
996285007703	I-site; other site
996285007704	potential frameshift: common BLAST hit: gi|241662234|ref|YP_002980594.1| sodium/hydrogen exchanger
996285007705	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
996285007706	TrkA-N domain; Region: TrkA_N; pfam02254
996285007707	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
996285007708	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
996285007709	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996285007710	catalytic residues [active]
996285007711	FtsH Extracellular; Region: FtsH_ext; pfam06480
996285007712	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
996285007713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007714	Walker A motif; other site
996285007715	ATP binding site [chemical binding]; other site
996285007716	Walker B motif; other site
996285007717	arginine finger; other site
996285007718	Peptidase family M41; Region: Peptidase_M41; pfam01434
996285007719	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
996285007720	PLD-like domain; Region: PLDc_2; pfam13091
996285007721	putative active site [active]
996285007722	catalytic site [active]
996285007723	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
996285007724	PLD-like domain; Region: PLDc_2; pfam13091
996285007725	putative active site [active]
996285007726	catalytic site [active]
996285007727	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
996285007728	Clp amino terminal domain; Region: Clp_N; pfam02861
996285007729	Clp amino terminal domain; Region: Clp_N; pfam02861
996285007730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007731	Walker A motif; other site
996285007732	ATP binding site [chemical binding]; other site
996285007733	Walker B motif; other site
996285007734	arginine finger; other site
996285007735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007736	Walker A motif; other site
996285007737	ATP binding site [chemical binding]; other site
996285007738	Walker B motif; other site
996285007739	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996285007740	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
996285007741	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
996285007742	putative dimer interface [polypeptide binding]; other site
996285007743	putative transposase OrfB; Reviewed; Region: PHA02517
996285007744	HTH-like domain; Region: HTH_21; pfam13276
996285007745	Integrase core domain; Region: rve; pfam00665
996285007746	Integrase core domain; Region: rve_3; pfam13683
996285007747	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
996285007748	Transposase domain (DUF772); Region: DUF772; pfam05598
996285007749	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
996285007750	DDE superfamily endonuclease; Region: DDE_4; cl17710
996285007751	conjugal transfer protein TrbP; Provisional; Region: PRK13882
996285007752	TraX protein; Region: TraX; pfam05857
996285007753	Predicted membrane protein [Function unknown]; Region: COG1238
996285007754	High-affinity nickel-transport protein; Region: NicO; cl00964
996285007755	High-affinity nickel-transport protein; Region: NicO; cl00964
996285007756	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
996285007757	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
996285007758	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
996285007759	metal binding site [ion binding]; metal-binding site
996285007760	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
996285007761	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285007762	Walker A motif; other site
996285007763	ATP binding site [chemical binding]; other site
996285007764	Walker B motif; other site
996285007765	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
996285007766	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
996285007767	ATP binding site [chemical binding]; other site
996285007768	Walker A motif; other site
996285007769	hexamer interface [polypeptide binding]; other site
996285007770	Walker B motif; other site
996285007771	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
996285007772	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
996285007773	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
996285007774	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
996285007775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285007776	Walker B; other site
996285007777	D-loop; other site
996285007778	H-loop/switch region; other site
996285007779	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
996285007780	conjugal transfer protein TrbL; Provisional; Region: PRK13875
996285007781	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
996285007782	conjugal transfer protein TrbF; Provisional; Region: PRK13872
996285007783	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
996285007784	VirB7 interaction site; other site
996285007785	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
996285007786	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
996285007787	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
996285007788	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
996285007789	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285007790	sequence-specific DNA binding site [nucleotide binding]; other site
996285007791	salt bridge; other site
996285007792	HipA N-terminal domain; Region: Couple_hipA; pfam13657
996285007793	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
996285007794	HipA-like N-terminal domain; Region: HipA_N; pfam07805
996285007795	HipA-like C-terminal domain; Region: HipA_C; pfam07804
996285007796	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
996285007797	sequence-specific DNA binding site [nucleotide binding]; other site
996285007798	salt bridge; other site
996285007799	putative transposase OrfB; Reviewed; Region: PHA02517
996285007800	HTH-like domain; Region: HTH_21; pfam13276
996285007801	Integrase core domain; Region: rve; pfam00665
996285007802	Integrase core domain; Region: rve_3; pfam13683
996285007803	Transposase; Region: HTH_Tnp_1; pfam01527
996285007804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
996285007805	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
996285007806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285007807	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
996285007808	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285007809	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
996285007810	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
996285007811	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
996285007812	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285007813	active site
996285007814	DNA binding site [nucleotide binding]
996285007815	Int/Topo IB signature motif; other site
996285007816	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
996285007817	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996285007818	DNA binding residues [nucleotide binding]
996285007819	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
996285007820	IHF dimer interface [polypeptide binding]; other site
996285007821	IHF - DNA interface [nucleotide binding]; other site
996285007822	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
996285007823	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
996285007824	putative tRNA-binding site [nucleotide binding]; other site
996285007825	B3/4 domain; Region: B3_4; pfam03483
996285007826	tRNA synthetase B5 domain; Region: B5; smart00874
996285007827	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
996285007828	dimer interface [polypeptide binding]; other site
996285007829	motif 1; other site
996285007830	motif 3; other site
996285007831	motif 2; other site
996285007832	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
996285007833	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
996285007834	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
996285007835	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
996285007836	dimer interface [polypeptide binding]; other site
996285007837	motif 1; other site
996285007838	active site
996285007839	motif 2; other site
996285007840	motif 3; other site
996285007841	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
996285007842	23S rRNA binding site [nucleotide binding]; other site
996285007843	L21 binding site [polypeptide binding]; other site
996285007844	L13 binding site [polypeptide binding]; other site
996285007845	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
996285007846	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
996285007847	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
996285007848	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
996285007849	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
996285007850	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
996285007851	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
996285007852	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
996285007853	active site
996285007854	dimer interface [polypeptide binding]; other site
996285007855	motif 1; other site
996285007856	motif 2; other site
996285007857	motif 3; other site
996285007858	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
996285007859	anticodon binding site; other site
996285007860	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
996285007861	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
996285007862	potential frameshift: common BLAST hit: gi|320158240|ref|YP_004190618.1| membrane protein
996285007863	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
996285007864	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
996285007865	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
996285007866	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
996285007867	outer membrane porin, OprD family; Region: OprD; pfam03573
996285007868	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
996285007869	Predicted membrane protein [Function unknown]; Region: COG5393
996285007870	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
996285007871	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
996285007872	Zn2+ binding site [ion binding]; other site
996285007873	Mg2+ binding site [ion binding]; other site
996285007874	hypothetical protein; Provisional; Region: PRK11702
996285007875	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
996285007876	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
996285007877	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
996285007878	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
996285007879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
996285007880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285007881	S-adenosylmethionine binding site [chemical binding]; other site
996285007882	Ribosome modulation factor; Region: RMF; pfam04957
996285007883	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
996285007884	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
996285007885	quinone interaction residues [chemical binding]; other site
996285007886	active site
996285007887	catalytic residues [active]
996285007888	FMN binding site [chemical binding]; other site
996285007889	substrate binding site [chemical binding]; other site
996285007890	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
996285007891	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
996285007892	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
996285007893	MoxR-like ATPases [General function prediction only]; Region: COG0714
996285007894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285007895	Walker A motif; other site
996285007896	ATP binding site [chemical binding]; other site
996285007897	Walker B motif; other site
996285007898	arginine finger; other site
996285007899	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
996285007900	Protein of unknown function DUF58; Region: DUF58; pfam01882
996285007901	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
996285007902	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
996285007903	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
996285007904	metal ion-dependent adhesion site (MIDAS); other site
996285007905	von Willebrand factor type A domain; Region: VWA_2; pfam13519
996285007906	metal ion-dependent adhesion site (MIDAS); other site
996285007907	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285007908	TPR motif; other site
996285007909	binding surface
996285007910	TPR repeat; Region: TPR_11; pfam13414
996285007911	Oxygen tolerance; Region: BatD; pfam13584
996285007912	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285007913	NMT1-like family; Region: NMT1_2; pfam13379
996285007914	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
996285007915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285007916	active site
996285007917	phosphorylation site [posttranslational modification]
996285007918	intermolecular recognition site; other site
996285007919	dimerization interface [polypeptide binding]; other site
996285007920	ANTAR domain; Region: ANTAR; pfam03861
996285007921	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
996285007922	active site
996285007923	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
996285007924	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
996285007925	putative substrate binding site [chemical binding]; other site
996285007926	putative ATP binding site [chemical binding]; other site
996285007927	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
996285007928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285007929	putative substrate translocation pore; other site
996285007930	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
996285007931	active site
996285007932	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
996285007933	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996285007934	active site
996285007935	ATP binding site [chemical binding]; other site
996285007936	substrate binding site [chemical binding]; other site
996285007937	activation loop (A-loop); other site
996285007938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
996285007939	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
996285007940	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285007941	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
996285007942	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
996285007943	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
996285007944	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
996285007945	[2Fe-2S] cluster binding site [ion binding]; other site
996285007946	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
996285007947	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
996285007948	molybdopterin cofactor binding site; other site
996285007949	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
996285007950	molybdopterin cofactor binding site; other site
996285007951	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
996285007952	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
996285007953	active site
996285007954	SAM binding site [chemical binding]; other site
996285007955	homodimer interface [polypeptide binding]; other site
996285007956	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
996285007957	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
996285007958	aminopeptidase N; Provisional; Region: pepN; PRK14015
996285007959	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
996285007960	active site
996285007961	Zn binding site [ion binding]; other site
996285007962	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
996285007963	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
996285007964	Rhomboid family; Region: Rhomboid; pfam01694
996285007965	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
996285007966	active site
996285007967	metal binding site [ion binding]; metal-binding site
996285007968	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
996285007969	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
996285007970	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
996285007971	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
996285007972	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
996285007973	Chromate transporter; Region: Chromate_transp; pfam02417
996285007974	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996285007975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285007976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285007977	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285007978	putative effector binding pocket; other site
996285007979	dimerization interface [polypeptide binding]; other site
996285007980	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
996285007981	spermidine synthase; Provisional; Region: PRK00811
996285007982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285007983	S-adenosylmethionine binding site [chemical binding]; other site
996285007984	AlkA N-terminal domain; Region: AlkA_N; pfam06029
996285007985	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
996285007986	minor groove reading motif; other site
996285007987	helix-hairpin-helix signature motif; other site
996285007988	active site
996285007989	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
996285007990	catalytic core [active]
996285007991	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
996285007992	Cupin domain; Region: Cupin_2; cl17218
996285007993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285007994	putative substrate translocation pore; other site
996285007995	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
996285007996	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
996285007997	Tetramer interface [polypeptide binding]; other site
996285007998	active site
996285007999	FMN-binding site [chemical binding]; other site
996285008000	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
996285008001	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
996285008002	trimer interface; other site
996285008003	sugar binding site [chemical binding]; other site
996285008004	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
996285008005	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
996285008006	Walker A/P-loop; other site
996285008007	ATP binding site [chemical binding]; other site
996285008008	Q-loop/lid; other site
996285008009	ABC transporter signature motif; other site
996285008010	Walker B; other site
996285008011	D-loop; other site
996285008012	H-loop/switch region; other site
996285008013	TOBE domain; Region: TOBE; pfam03459
996285008014	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
996285008015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285008016	dimer interface [polypeptide binding]; other site
996285008017	conserved gate region; other site
996285008018	putative PBP binding loops; other site
996285008019	ABC-ATPase subunit interface; other site
996285008020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285008021	dimer interface [polypeptide binding]; other site
996285008022	conserved gate region; other site
996285008023	putative PBP binding loops; other site
996285008024	ABC-ATPase subunit interface; other site
996285008025	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
996285008026	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
996285008027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285008028	dimerization interface [polypeptide binding]; other site
996285008029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285008030	ATP binding site [chemical binding]; other site
996285008031	Mg2+ binding site [ion binding]; other site
996285008032	G-X-G motif; other site
996285008033	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285008034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008035	active site
996285008036	phosphorylation site [posttranslational modification]
996285008037	intermolecular recognition site; other site
996285008038	dimerization interface [polypeptide binding]; other site
996285008039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285008040	DNA binding site [nucleotide binding]
996285008041	glucokinase, proteobacterial type; Region: glk; TIGR00749
996285008042	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
996285008043	nucleotide binding site [chemical binding]; other site
996285008044	phosphogluconate dehydratase; Validated; Region: PRK09054
996285008045	6-phosphogluconate dehydratase; Region: edd; TIGR01196
996285008046	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
996285008047	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
996285008048	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
996285008049	active site
996285008050	HIGH motif; other site
996285008051	dimer interface [polypeptide binding]; other site
996285008052	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996285008053	active site
996285008054	KMSKS motif; other site
996285008055	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
996285008056	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
996285008057	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
996285008058	active site
996285008059	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
996285008060	YciI-like protein; Reviewed; Region: PRK11370
996285008061	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
996285008062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008063	active site
996285008064	phosphorylation site [posttranslational modification]
996285008065	intermolecular recognition site; other site
996285008066	dimerization interface [polypeptide binding]; other site
996285008067	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285008068	DNA binding site [nucleotide binding]
996285008069	synthase/transferase; Region: PLN02316
996285008070	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285008071	HAMP domain; Region: HAMP; pfam00672
996285008072	dimerization interface [polypeptide binding]; other site
996285008073	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285008074	dimer interface [polypeptide binding]; other site
996285008075	phosphorylation site [posttranslational modification]
996285008076	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285008077	ATP binding site [chemical binding]; other site
996285008078	G-X-G motif; other site
996285008079	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
996285008080	putative FMN binding site [chemical binding]; other site
996285008081	Flagellin N-methylase; Region: FliB; pfam03692
996285008082	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
996285008083	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
996285008084	Protein of unknown function (DUF808); Region: DUF808; pfam05661
996285008085	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
996285008086	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285008087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285008088	Protein of unknown function (DUF962); Region: DUF962; cl01879
996285008089	MASE2 domain; Region: MASE2; pfam05230
996285008090	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
996285008091	cyclase homology domain; Region: CHD; cd07302
996285008092	nucleotidyl binding site; other site
996285008093	metal binding site [ion binding]; metal-binding site
996285008094	dimer interface [polypeptide binding]; other site
996285008095	Cupin domain; Region: Cupin_2; cl17218
996285008096	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285008097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285008098	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285008099	EamA-like transporter family; Region: EamA; pfam00892
996285008100	Rdx family; Region: Rdx; cl01407
996285008101	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
996285008102	hypothetical protein; Provisional; Region: PRK10279
996285008103	active site
996285008104	nucleophile elbow; other site
996285008105	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
996285008106	Surface antigen; Region: Bac_surface_Ag; pfam01103
996285008107	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
996285008108	MarR family; Region: MarR_2; pfam12802
996285008109	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
996285008110	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285008111	ATP binding site [chemical binding]; other site
996285008112	putative Mg++ binding site [ion binding]; other site
996285008113	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285008114	nucleotide binding region [chemical binding]; other site
996285008115	ATP-binding site [chemical binding]; other site
996285008116	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
996285008117	HRDC domain; Region: HRDC; pfam00570
996285008118	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
996285008119	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
996285008120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
996285008121	DTW domain; Region: DTW; cl01221
996285008122	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285008123	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
996285008124	putative C-terminal domain interface [polypeptide binding]; other site
996285008125	putative GSH binding site (G-site) [chemical binding]; other site
996285008126	putative dimer interface [polypeptide binding]; other site
996285008127	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
996285008128	putative N-terminal domain interface [polypeptide binding]; other site
996285008129	putative dimer interface [polypeptide binding]; other site
996285008130	putative substrate binding pocket (H-site) [chemical binding]; other site
996285008131	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
996285008132	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
996285008133	EamA-like transporter family; Region: EamA; pfam00892
996285008134	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
996285008135	EamA-like transporter family; Region: EamA; pfam00892
996285008136	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
996285008137	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
996285008138	dimer interface [polypeptide binding]; other site
996285008139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285008140	catalytic residue [active]
996285008141	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
996285008142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285008143	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
996285008144	Walker A motif; other site
996285008145	ATP binding site [chemical binding]; other site
996285008146	Walker B motif; other site
996285008147	arginine finger; other site
996285008148	Uncharacterized conserved protein [Function unknown]; Region: COG3791
996285008149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
996285008150	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
996285008151	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
996285008152	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
996285008153	putative active site [active]
996285008154	putative dimer interface [polypeptide binding]; other site
996285008155	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285008156	Ligand Binding Site [chemical binding]; other site
996285008157	ABC transporter ATPase component; Reviewed; Region: PRK11147
996285008158	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285008159	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285008160	ABC transporter; Region: ABC_tran_2; pfam12848
996285008161	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
996285008162	lytic murein transglycosylase; Provisional; Region: PRK11619
996285008163	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285008164	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285008165	catalytic residue [active]
996285008166	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
996285008167	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
996285008168	MOSC domain; Region: MOSC; pfam03473
996285008169	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
996285008170	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285008171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008172	active site
996285008173	phosphorylation site [posttranslational modification]
996285008174	intermolecular recognition site; other site
996285008175	dimerization interface [polypeptide binding]; other site
996285008176	lipid kinase; Reviewed; Region: PRK13054
996285008177	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
996285008178	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
996285008179	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
996285008180	Low molecular weight phosphatase family; Region: LMWPc; cd00115
996285008181	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
996285008182	active site
996285008183	tyrosine kinase; Provisional; Region: PRK11519
996285008184	Chain length determinant protein; Region: Wzz; pfam02706
996285008185	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
996285008186	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996285008187	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
996285008188	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
996285008189	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
996285008190	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
996285008191	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
996285008192	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
996285008193	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
996285008194	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
996285008195	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
996285008196	Probable Catalytic site; other site
996285008197	metal-binding site
996285008198	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
996285008199	polysaccharide export protein Wza; Provisional; Region: PRK15078
996285008200	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
996285008201	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
996285008202	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
996285008203	dimer interface [polypeptide binding]; other site
996285008204	active site
996285008205	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
996285008206	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
996285008207	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
996285008208	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
996285008209	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
996285008210	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
996285008211	IHF dimer interface [polypeptide binding]; other site
996285008212	IHF - DNA interface [nucleotide binding]; other site
996285008213	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
996285008214	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996285008215	ATP binding site [chemical binding]; other site
996285008216	Mg++ binding site [ion binding]; other site
996285008217	motif III; other site
996285008218	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285008219	nucleotide binding region [chemical binding]; other site
996285008220	ATP-binding site [chemical binding]; other site
996285008221	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
996285008222	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
996285008223	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285008224	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285008225	dimer interface [polypeptide binding]; other site
996285008226	putative CheW interface [polypeptide binding]; other site
996285008227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285008228	S-adenosylmethionine binding site [chemical binding]; other site
996285008229	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
996285008230	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
996285008231	transmembrane helices; other site
996285008232	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
996285008233	elongation factor P; Validated; Region: PRK00529
996285008234	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
996285008235	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
996285008236	RNA binding site [nucleotide binding]; other site
996285008237	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
996285008238	RNA binding site [nucleotide binding]; other site
996285008239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
996285008240	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
996285008241	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
996285008242	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285008243	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
996285008244	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
996285008245	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285008246	ligand binding site [chemical binding]; other site
996285008247	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
996285008248	ZIP Zinc transporter; Region: Zip; pfam02535
996285008249	potential frameshift: common BLAST hit: gi|339494523|ref|YP_004714816.1| membrane fusion protein
996285008250	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
996285008251	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285008252	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
996285008253	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996285008254	FtsX-like permease family; Region: FtsX; pfam02687
996285008255	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
996285008256	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996285008257	Walker A/P-loop; other site
996285008258	ATP binding site [chemical binding]; other site
996285008259	Q-loop/lid; other site
996285008260	ABC transporter signature motif; other site
996285008261	Walker B; other site
996285008262	D-loop; other site
996285008263	H-loop/switch region; other site
996285008264	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
996285008265	Putative phosphatase (DUF442); Region: DUF442; cl17385
996285008266	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
996285008267	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285008268	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
996285008269	high affinity sulphate transporter 1; Region: sulP; TIGR00815
996285008270	Sulfate transporter family; Region: Sulfate_transp; pfam00916
996285008271	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
996285008272	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
996285008273	active site residue [active]
996285008274	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
996285008275	Predicted transporter component [General function prediction only]; Region: COG2391
996285008276	Sulphur transport; Region: Sulf_transp; pfam04143
996285008277	Predicted transporter component [General function prediction only]; Region: COG2391
996285008278	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285008279	dimerization interface [polypeptide binding]; other site
996285008280	putative DNA binding site [nucleotide binding]; other site
996285008281	putative Zn2+ binding site [ion binding]; other site
996285008282	Uncharacterized family 4; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_4; cd10161
996285008283	putative homodimer interface [polypeptide binding]; other site
996285008284	putative homotetramer interface [polypeptide binding]; other site
996285008285	putative metal binding site [ion binding]; other site
996285008286	putative homodimer-homodimer interface [polypeptide binding]; other site
996285008287	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
996285008288	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285008289	C-terminal domain interface [polypeptide binding]; other site
996285008290	GSH binding site (G-site) [chemical binding]; other site
996285008291	dimer interface [polypeptide binding]; other site
996285008292	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
996285008293	N-terminal domain interface [polypeptide binding]; other site
996285008294	dimer interface [polypeptide binding]; other site
996285008295	substrate binding pocket (H-site) [chemical binding]; other site
996285008296	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
996285008297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285008298	Walker A motif; other site
996285008299	ATP binding site [chemical binding]; other site
996285008300	Walker B motif; other site
996285008301	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
996285008302	catalytic residues [active]
996285008303	dimer interface [polypeptide binding]; other site
996285008304	methionine sulfoxide reductase B; Provisional; Region: PRK00222
996285008305	SelR domain; Region: SelR; pfam01641
996285008306	aminotransferase AlaT; Validated; Region: PRK09265
996285008307	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285008308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285008309	homodimer interface [polypeptide binding]; other site
996285008310	catalytic residue [active]
996285008311	heat shock protein HtpX; Provisional; Region: PRK05457
996285008312	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
996285008313	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
996285008314	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
996285008315	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285008316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008317	active site
996285008318	phosphorylation site [posttranslational modification]
996285008319	intermolecular recognition site; other site
996285008320	dimerization interface [polypeptide binding]; other site
996285008321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285008322	Walker A motif; other site
996285008323	ATP binding site [chemical binding]; other site
996285008324	Walker B motif; other site
996285008325	arginine finger; other site
996285008326	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285008327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285008328	dimer interface [polypeptide binding]; other site
996285008329	phosphorylation site [posttranslational modification]
996285008330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285008331	ATP binding site [chemical binding]; other site
996285008332	Mg2+ binding site [ion binding]; other site
996285008333	G-X-G motif; other site
996285008334	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285008335	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
996285008336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285008337	Walker A motif; other site
996285008338	ATP binding site [chemical binding]; other site
996285008339	Walker B motif; other site
996285008340	arginine finger; other site
996285008341	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285008342	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285008343	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285008344	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
996285008345	TPR repeat; Region: TPR_11; pfam13414
996285008346	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285008347	binding surface
996285008348	TPR motif; other site
996285008349	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
996285008350	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
996285008351	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
996285008352	catalytic residues [active]
996285008353	central insert; other site
996285008354	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
996285008355	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
996285008356	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
996285008357	heme exporter protein CcmC; Region: ccmC; TIGR01191
996285008358	heme exporter protein CcmB; Region: ccmB; TIGR01190
996285008359	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
996285008360	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
996285008361	Walker A/P-loop; other site
996285008362	ATP binding site [chemical binding]; other site
996285008363	Q-loop/lid; other site
996285008364	ABC transporter signature motif; other site
996285008365	Walker B; other site
996285008366	D-loop; other site
996285008367	H-loop/switch region; other site
996285008368	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
996285008369	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
996285008370	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
996285008371	active site residue [active]
996285008372	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
996285008373	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
996285008374	putative CheA interaction surface; other site
996285008375	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
996285008376	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
996285008377	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285008378	Magnesium ion binding site [ion binding]; other site
996285008379	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285008380	Magnesium ion binding site [ion binding]; other site
996285008381	flagellar motor protein MotD; Reviewed; Region: PRK09038
996285008382	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
996285008383	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285008384	ligand binding site [chemical binding]; other site
996285008385	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
996285008386	flagellar motor protein; Reviewed; Region: motC; PRK09109
996285008387	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
996285008388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008389	active site
996285008390	phosphorylation site [posttranslational modification]
996285008391	intermolecular recognition site; other site
996285008392	dimerization interface [polypeptide binding]; other site
996285008393	CheB methylesterase; Region: CheB_methylest; pfam01339
996285008394	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285008395	putative binding surface; other site
996285008396	active site
996285008397	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
996285008398	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
996285008399	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285008400	ATP binding site [chemical binding]; other site
996285008401	Mg2+ binding site [ion binding]; other site
996285008402	G-X-G motif; other site
996285008403	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
996285008404	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
996285008405	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
996285008406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008407	active site
996285008408	phosphorylation site [posttranslational modification]
996285008409	intermolecular recognition site; other site
996285008410	dimerization interface [polypeptide binding]; other site
996285008411	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
996285008412	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285008413	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
996285008414	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285008415	DNA binding residues [nucleotide binding]
996285008416	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
996285008417	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996285008418	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
996285008419	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
996285008420	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
996285008421	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
996285008422	FHIPEP family; Region: FHIPEP; pfam00771
996285008423	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
996285008424	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
996285008425	E-class dimer interface [polypeptide binding]; other site
996285008426	P-class dimer interface [polypeptide binding]; other site
996285008427	active site
996285008428	Cu2+ binding site [ion binding]; other site
996285008429	Zn2+ binding site [ion binding]; other site
996285008430	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
996285008431	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
996285008432	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
996285008433	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
996285008434	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
996285008435	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
996285008436	flagellar motor switch protein; Validated; Region: fliN; PRK05698
996285008437	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
996285008438	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
996285008439	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
996285008440	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
996285008441	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
996285008442	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285008443	putative binding surface; other site
996285008444	active site
996285008445	Response regulator receiver domain; Region: Response_reg; pfam00072
996285008446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008447	active site
996285008448	phosphorylation site [posttranslational modification]
996285008449	intermolecular recognition site; other site
996285008450	dimerization interface [polypeptide binding]; other site
996285008451	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
996285008452	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
996285008453	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
996285008454	anti sigma factor interaction site; other site
996285008455	regulatory phosphorylation site [posttranslational modification]; other site
996285008456	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
996285008457	Flagellar FliJ protein; Region: FliJ; pfam02050
996285008458	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
996285008459	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
996285008460	Walker A motif/ATP binding site; other site
996285008461	Walker B motif; other site
996285008462	flagellar assembly protein H; Validated; Region: fliH; PRK05687
996285008463	Flagellar assembly protein FliH; Region: FliH; pfam02108
996285008464	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
996285008465	MgtE intracellular N domain; Region: MgtE_N; smart00924
996285008466	FliG C-terminal domain; Region: FliG_C; pfam01706
996285008467	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
996285008468	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
996285008469	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
996285008470	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
996285008471	benzoate transporter; Region: benE; TIGR00843
996285008472	Benzoate membrane transport protein; Region: BenE; pfam03594
996285008473	short chain dehydrogenase; Provisional; Region: PRK06172
996285008474	classical (c) SDRs; Region: SDR_c; cd05233
996285008475	NAD(P) binding site [chemical binding]; other site
996285008476	active site
996285008477	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
996285008478	Prostaglandin dehydrogenases; Region: PGDH; cd05288
996285008479	NAD(P) binding site [chemical binding]; other site
996285008480	substrate binding site [chemical binding]; other site
996285008481	dimer interface [polypeptide binding]; other site
996285008482	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
996285008483	active site
996285008484	dimer interface [polypeptide binding]; other site
996285008485	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
996285008486	CHASE4 domain; Region: CHASE4; pfam05228
996285008487	PAS domain S-box; Region: sensory_box; TIGR00229
996285008488	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285008489	putative active site [active]
996285008490	heme pocket [chemical binding]; other site
996285008491	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285008492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285008493	metal binding site [ion binding]; metal-binding site
996285008494	active site
996285008495	I-site; other site
996285008496	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285008497	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
996285008498	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285008499	DNA-binding site [nucleotide binding]; DNA binding site
996285008500	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285008501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285008502	homodimer interface [polypeptide binding]; other site
996285008503	catalytic residue [active]
996285008504	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
996285008505	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285008506	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285008507	ligand binding site [chemical binding]; other site
996285008508	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
996285008509	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285008510	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285008511	substrate binding pocket [chemical binding]; other site
996285008512	membrane-bound complex binding site; other site
996285008513	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
996285008514	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
996285008515	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
996285008516	Ligand binding site [chemical binding]; other site
996285008517	Electron transfer flavoprotein domain; Region: ETF; pfam01012
996285008518	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
996285008519	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285008520	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
996285008521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
996285008522	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
996285008523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285008524	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
996285008525	FeS/SAM binding site; other site
996285008526	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
996285008527	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
996285008528	Acid Phosphatase; Region: Acid_PPase; cl17256
996285008529	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
996285008530	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
996285008531	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
996285008532	Sulfate transporter family; Region: Sulfate_transp; pfam00916
996285008533	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
996285008534	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285008535	Ligand Binding Site [chemical binding]; other site
996285008536	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
996285008537	Ligand Binding Site [chemical binding]; other site
996285008538	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
996285008539	SdiA-regulated; Region: SdiA-regulated; pfam06977
996285008540	SdiA-regulated; Region: SdiA-regulated; cd09971
996285008541	putative active site [active]
996285008542	putative transposase OrfB; Reviewed; Region: PHA02517
996285008543	HTH-like domain; Region: HTH_21; pfam13276
996285008544	Integrase core domain; Region: rve; pfam00665
996285008545	Integrase core domain; Region: rve_3; pfam13683
996285008546	putative transposase OrfB; Reviewed; Region: PHA02517
996285008547	HTH-like domain; Region: HTH_21; pfam13276
996285008548	Integrase core domain; Region: rve; pfam00665
996285008549	Integrase core domain; Region: rve_2; pfam13333
996285008550	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
996285008551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285008552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285008553	WHG domain; Region: WHG; pfam13305
996285008554	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
996285008555	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
996285008556	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285008557	catalytic residue [active]
996285008558	aromatic amino acid transporter; Provisional; Region: PRK10238
996285008559	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
996285008560	active site
996285008561	PilZ domain; Region: PilZ; cl01260
996285008562	DNA polymerase III subunit delta'; Validated; Region: PRK05707
996285008563	thymidylate kinase; Validated; Region: tmk; PRK00698
996285008564	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
996285008565	TMP-binding site; other site
996285008566	ATP-binding site [chemical binding]; other site
996285008567	YceG-like family; Region: YceG; pfam02618
996285008568	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
996285008569	dimerization interface [polypeptide binding]; other site
996285008570	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
996285008571	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
996285008572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285008573	catalytic residue [active]
996285008574	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
996285008575	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
996285008576	dimer interface [polypeptide binding]; other site
996285008577	active site
996285008578	acyl carrier protein; Provisional; Region: acpP; PRK00982
996285008579	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
996285008580	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
996285008581	NAD(P) binding site [chemical binding]; other site
996285008582	homotetramer interface [polypeptide binding]; other site
996285008583	homodimer interface [polypeptide binding]; other site
996285008584	active site
996285008585	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
996285008586	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
996285008587	putative phosphate acyltransferase; Provisional; Region: PRK05331
996285008588	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
996285008589	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
996285008590	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
996285008591	active site
996285008592	dimer interface [polypeptide binding]; other site
996285008593	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
996285008594	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
996285008595	tandem repeat interface [polypeptide binding]; other site
996285008596	oligomer interface [polypeptide binding]; other site
996285008597	active site residues [active]
996285008598	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
996285008599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285008600	motif II; other site
996285008601	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
996285008602	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285008603	RNA binding surface [nucleotide binding]; other site
996285008604	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
996285008605	active site
996285008606	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
996285008607	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
996285008608	homodimer interface [polypeptide binding]; other site
996285008609	oligonucleotide binding site [chemical binding]; other site
996285008610	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
996285008611	FAD binding domain; Region: FAD_binding_4; pfam01565
996285008612	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
996285008613	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
996285008614	Low molecular weight phosphatase family; Region: LMWPc; cd00115
996285008615	active site
996285008616	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
996285008617	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
996285008618	Ligand binding site; other site
996285008619	oligomer interface; other site
996285008620	Uncharacterized conserved protein [Function unknown]; Region: COG2835
996285008621	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
996285008622	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
996285008623	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
996285008624	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
996285008625	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
996285008626	ComEC family competence protein; Provisional; Region: PRK11539
996285008627	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
996285008628	Competence protein; Region: Competence; pfam03772
996285008629	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
996285008630	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
996285008631	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
996285008632	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996285008633	FtsX-like permease family; Region: FtsX; pfam02687
996285008634	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
996285008635	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
996285008636	Walker A/P-loop; other site
996285008637	ATP binding site [chemical binding]; other site
996285008638	Q-loop/lid; other site
996285008639	ABC transporter signature motif; other site
996285008640	Walker B; other site
996285008641	D-loop; other site
996285008642	H-loop/switch region; other site
996285008643	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
996285008644	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
996285008645	FtsX-like permease family; Region: FtsX; pfam02687
996285008646	PilZ domain; Region: PilZ; pfam07238
996285008647	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
996285008648	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
996285008649	active site
996285008650	catalytic site [active]
996285008651	metal binding site [ion binding]; metal-binding site
996285008652	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
996285008653	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
996285008654	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285008655	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
996285008656	Protein of unknown function (DUF539); Region: DUF539; cl01129
996285008657	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
996285008658	ApbE family; Region: ApbE; pfam02424
996285008659	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
996285008660	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285008661	catalytic loop [active]
996285008662	iron binding site [ion binding]; other site
996285008663	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
996285008664	FAD binding pocket [chemical binding]; other site
996285008665	FAD binding motif [chemical binding]; other site
996285008666	phosphate binding motif [ion binding]; other site
996285008667	beta-alpha-beta structure motif; other site
996285008668	NAD binding pocket [chemical binding]; other site
996285008669	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
996285008670	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
996285008671	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
996285008672	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
996285008673	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
996285008674	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
996285008675	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
996285008676	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
996285008677	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
996285008678	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
996285008679	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
996285008680	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
996285008681	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285008682	ATP binding site [chemical binding]; other site
996285008683	putative Mg++ binding site [ion binding]; other site
996285008684	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285008685	nucleotide binding region [chemical binding]; other site
996285008686	ATP-binding site [chemical binding]; other site
996285008687	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
996285008688	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
996285008689	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
996285008690	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
996285008691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285008692	ATP binding site [chemical binding]; other site
996285008693	putative Mg++ binding site [ion binding]; other site
996285008694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285008695	nucleotide binding region [chemical binding]; other site
996285008696	ATP-binding site [chemical binding]; other site
996285008697	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
996285008698	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
996285008699	ATP-dependent DNA ligase; Validated; Region: PRK09247
996285008700	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
996285008701	active site
996285008702	DNA binding site [nucleotide binding]
996285008703	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
996285008704	DNA binding site [nucleotide binding]
996285008705	DEAD/DEAH box helicase; Region: DEAD; pfam00270
996285008706	putative Mg++ binding site [ion binding]; other site
996285008707	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285008708	nucleotide binding region [chemical binding]; other site
996285008709	ATP-binding site [chemical binding]; other site
996285008710	DEAD/H associated; Region: DEAD_assoc; pfam08494
996285008711	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
996285008712	putative active site [active]
996285008713	putative metal binding site [ion binding]; other site
996285008714	Erythromycin esterase; Region: Erythro_esteras; pfam05139
996285008715	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
996285008716	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
996285008717	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
996285008718	homodimer interface [polypeptide binding]; other site
996285008719	metal binding site [ion binding]; metal-binding site
996285008720	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
996285008721	homodimer interface [polypeptide binding]; other site
996285008722	active site
996285008723	putative chemical substrate binding site [chemical binding]; other site
996285008724	metal binding site [ion binding]; metal-binding site
996285008725	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
996285008726	HD domain; Region: HD_4; pfam13328
996285008727	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
996285008728	synthetase active site [active]
996285008729	NTP binding site [chemical binding]; other site
996285008730	metal binding site [ion binding]; metal-binding site
996285008731	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
996285008732	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
996285008733	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
996285008734	TRAM domain; Region: TRAM; pfam01938
996285008735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285008736	S-adenosylmethionine binding site [chemical binding]; other site
996285008737	cysteine synthase B; Region: cysM; TIGR01138
996285008738	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
996285008739	dimer interface [polypeptide binding]; other site
996285008740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285008741	catalytic residue [active]
996285008742	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
996285008743	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285008744	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
996285008745	putative dimerization interface [polypeptide binding]; other site
996285008746	Predicted membrane protein [Function unknown]; Region: COG2860
996285008747	UPF0126 domain; Region: UPF0126; pfam03458
996285008748	UPF0126 domain; Region: UPF0126; pfam03458
996285008749	Transposase domain (DUF772); Region: DUF772; pfam05598
996285008750	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
996285008751	DDE superfamily endonuclease; Region: DDE_4; cl17710
996285008752	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
996285008753	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285008754	dimerization interface [polypeptide binding]; other site
996285008755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285008756	dimer interface [polypeptide binding]; other site
996285008757	phosphorylation site [posttranslational modification]
996285008758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285008759	ATP binding site [chemical binding]; other site
996285008760	Mg2+ binding site [ion binding]; other site
996285008761	G-X-G motif; other site
996285008762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008763	active site
996285008764	phosphorylation site [posttranslational modification]
996285008765	intermolecular recognition site; other site
996285008766	dimerization interface [polypeptide binding]; other site
996285008767	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285008768	putative binding surface; other site
996285008769	active site
996285008770	Uncharacterized conserved protein [Function unknown]; Region: COG4121
996285008771	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
996285008772	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
996285008773	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996285008774	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
996285008775	potential frameshift: common BLAST hit: gi|146283018|ref|YP_001173171.1| LysR family transcriptional regulator
996285008776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285008777	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285008778	helicase 45; Provisional; Region: PTZ00424
996285008779	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996285008780	ATP binding site [chemical binding]; other site
996285008781	Mg++ binding site [ion binding]; other site
996285008782	motif III; other site
996285008783	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285008784	nucleotide binding region [chemical binding]; other site
996285008785	ATP-binding site [chemical binding]; other site
996285008786	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
996285008787	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285008788	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285008789	LysR substrate binding domain; Region: LysR_substrate; pfam03466
996285008790	dimerization interface [polypeptide binding]; other site
996285008791	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
996285008792	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
996285008793	substrate binding site [chemical binding]; other site
996285008794	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
996285008795	dinuclear metal binding motif [ion binding]; other site
996285008796	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
996285008797	Protein of unknown function, DUF482; Region: DUF482; pfam04339
996285008798	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
996285008799	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
996285008800	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
996285008801	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
996285008802	putative ATP binding site [chemical binding]; other site
996285008803	putative substrate interface [chemical binding]; other site
996285008804	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
996285008805	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
996285008806	metal binding site [ion binding]; metal-binding site
996285008807	dimer interface [polypeptide binding]; other site
996285008808	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
996285008809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285008810	S-adenosylmethionine binding site [chemical binding]; other site
996285008811	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996285008812	DNA-binding site [nucleotide binding]; DNA binding site
996285008813	RNA-binding motif; other site
996285008814	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
996285008815	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
996285008816	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
996285008817	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
996285008818	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996285008819	Walker A/P-loop; other site
996285008820	ATP binding site [chemical binding]; other site
996285008821	Q-loop/lid; other site
996285008822	ABC transporter signature motif; other site
996285008823	Walker B; other site
996285008824	D-loop; other site
996285008825	H-loop/switch region; other site
996285008826	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285008827	Coenzyme A binding pocket [chemical binding]; other site
996285008828	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
996285008829	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
996285008830	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
996285008831	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285008832	S-adenosylmethionine binding site [chemical binding]; other site
996285008833	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
996285008834	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
996285008835	putative acyl-acceptor binding pocket; other site
996285008836	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
996285008837	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285008838	Coenzyme A binding pocket [chemical binding]; other site
996285008839	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
996285008840	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
996285008841	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
996285008842	dimerization domain [polypeptide binding]; other site
996285008843	dimer interface [polypeptide binding]; other site
996285008844	catalytic residues [active]
996285008845	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
996285008846	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996285008847	catalytic residues [active]
996285008848	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
996285008849	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285008850	dimerization interface [polypeptide binding]; other site
996285008851	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285008852	dimer interface [polypeptide binding]; other site
996285008853	phosphorylation site [posttranslational modification]
996285008854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285008855	ATP binding site [chemical binding]; other site
996285008856	Mg2+ binding site [ion binding]; other site
996285008857	G-X-G motif; other site
996285008858	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
996285008859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285008860	active site
996285008861	phosphorylation site [posttranslational modification]
996285008862	intermolecular recognition site; other site
996285008863	dimerization interface [polypeptide binding]; other site
996285008864	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285008865	DNA binding site [nucleotide binding]
996285008866	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285008867	metal-binding site [ion binding]
996285008868	Predicted metal-binding protein [General function prediction only]; Region: COG3019
996285008869	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
996285008870	Multicopper oxidase; Region: Cu-oxidase; pfam00394
996285008871	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
996285008872	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
996285008873	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285008874	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
996285008875	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
996285008876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285008877	Coenzyme A binding pocket [chemical binding]; other site
996285008878	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
996285008879	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996285008880	Pirin-related protein [General function prediction only]; Region: COG1741
996285008881	Pirin; Region: Pirin; pfam02678
996285008882	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
996285008883	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996285008884	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
996285008885	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
996285008886	Ligand binding site; other site
996285008887	DXD motif; other site
996285008888	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
996285008889	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
996285008890	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
996285008891	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
996285008892	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
996285008893	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
996285008894	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
996285008895	LrgA family; Region: LrgA; cl00608
996285008896	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
996285008897	4Fe-4S binding domain; Region: Fer4_5; pfam12801
996285008898	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285008899	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
996285008900	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
996285008901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285008902	DNA-binding site [nucleotide binding]; DNA binding site
996285008903	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285008904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285008905	homodimer interface [polypeptide binding]; other site
996285008906	catalytic residue [active]
996285008907	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
996285008908	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285008909	GAF domain; Region: GAF; pfam01590
996285008910	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285008911	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285008912	metal binding site [ion binding]; metal-binding site
996285008913	active site
996285008914	I-site; other site
996285008915	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285008916	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
996285008917	putative C-terminal domain interface [polypeptide binding]; other site
996285008918	putative GSH binding site (G-site) [chemical binding]; other site
996285008919	putative dimer interface [polypeptide binding]; other site
996285008920	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
996285008921	N-terminal domain interface [polypeptide binding]; other site
996285008922	dimer interface [polypeptide binding]; other site
996285008923	substrate binding pocket (H-site) [chemical binding]; other site
996285008924	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285008925	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285008926	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
996285008927	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
996285008928	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285008929	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285008930	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285008931	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285008932	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
996285008933	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
996285008934	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
996285008935	Protein of unknown function DUF72; Region: DUF72; cl00777
996285008936	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
996285008937	Glycoprotease family; Region: Peptidase_M22; pfam00814
996285008938	adenylate kinase; Reviewed; Region: adk; PRK00279
996285008939	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
996285008940	AMP-binding site [chemical binding]; other site
996285008941	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
996285008942	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
996285008943	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
996285008944	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
996285008945	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285008946	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285008947	ligand binding site [chemical binding]; other site
996285008948	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
996285008949	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
996285008950	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
996285008951	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
996285008952	dimer interface [polypeptide binding]; other site
996285008953	putative anticodon binding site; other site
996285008954	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
996285008955	motif 1; other site
996285008956	active site
996285008957	motif 2; other site
996285008958	motif 3; other site
996285008959	peptide chain release factor 2; Validated; Region: prfB; PRK00578
996285008960	This domain is found in peptide chain release factors; Region: PCRF; smart00937
996285008961	RF-1 domain; Region: RF-1; pfam00472
996285008962	Protein of unknown function (DUF533); Region: DUF533; pfam04391
996285008963	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
996285008964	putative metal binding site [ion binding]; other site
996285008965	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
996285008966	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
996285008967	active site
996285008968	FMN binding site [chemical binding]; other site
996285008969	substrate binding site [chemical binding]; other site
996285008970	homotetramer interface [polypeptide binding]; other site
996285008971	catalytic residue [active]
996285008972	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
996285008973	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
996285008974	putative [Fe4-S4] binding site [ion binding]; other site
996285008975	putative molybdopterin cofactor binding site [chemical binding]; other site
996285008976	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
996285008977	putative molybdopterin cofactor binding site; other site
996285008978	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
996285008979	DHH family; Region: DHH; pfam01368
996285008980	DHHA1 domain; Region: DHHA1; pfam02272
996285008981	MarR family; Region: MarR_2; cl17246
996285008982	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
996285008983	putative active site [active]
996285008984	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
996285008985	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
996285008986	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
996285008987	hypothetical protein; Provisional; Region: PRK05463
996285008988	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
996285008989	YaeQ protein; Region: YaeQ; pfam07152
996285008990	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285008991	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285008992	metal binding site [ion binding]; metal-binding site
996285008993	active site
996285008994	I-site; other site
996285008995	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
996285008996	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
996285008997	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
996285008998	heme binding site [chemical binding]; other site
996285008999	ferroxidase pore; other site
996285009000	ferroxidase diiron center [ion binding]; other site
996285009001	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
996285009002	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
996285009003	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
996285009004	recombination associated protein; Reviewed; Region: rdgC; PRK00321
996285009005	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
996285009006	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
996285009007	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
996285009008	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
996285009009	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
996285009010	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
996285009011	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
996285009012	Na binding site [ion binding]; other site
996285009013	PAS domain; Region: PAS; smart00091
996285009014	PAS fold; Region: PAS_7; pfam12860
996285009015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285009016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285009017	dimer interface [polypeptide binding]; other site
996285009018	phosphorylation site [posttranslational modification]
996285009019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285009020	ATP binding site [chemical binding]; other site
996285009021	Mg2+ binding site [ion binding]; other site
996285009022	G-X-G motif; other site
996285009023	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285009024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285009025	active site
996285009026	phosphorylation site [posttranslational modification]
996285009027	intermolecular recognition site; other site
996285009028	dimerization interface [polypeptide binding]; other site
996285009029	Predicted membrane protein [Function unknown]; Region: COG3174
996285009030	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
996285009031	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
996285009032	RmuC family; Region: RmuC; pfam02646
996285009033	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
996285009034	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
996285009035	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
996285009036	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
996285009037	DNA polymerase II; Reviewed; Region: PRK05762
996285009038	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
996285009039	active site
996285009040	catalytic site [active]
996285009041	substrate binding site [chemical binding]; other site
996285009042	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
996285009043	active site
996285009044	metal-binding site
996285009045	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
996285009046	ATP binding site [chemical binding]; other site
996285009047	active site
996285009048	substrate binding site [chemical binding]; other site
996285009049	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
996285009050	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
996285009051	dihydrodipicolinate synthase; Region: dapA; TIGR00674
996285009052	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
996285009053	dimer interface [polypeptide binding]; other site
996285009054	active site
996285009055	catalytic residue [active]
996285009056	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
996285009057	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
996285009058	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
996285009059	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
996285009060	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
996285009061	catalytic triad [active]
996285009062	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
996285009063	Domain of unknown function DUF20; Region: UPF0118; pfam01594
996285009064	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
996285009065	CPxP  motif; other site
996285009066	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
996285009067	Peptidase family M48; Region: Peptidase_M48; cl12018
996285009068	quinolinate synthetase; Provisional; Region: PRK09375
996285009069	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
996285009070	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
996285009071	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
996285009072	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
996285009073	Ligand Binding Site [chemical binding]; other site
996285009074	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
996285009075	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285009076	FeS/SAM binding site; other site
996285009077	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
996285009078	Tetratricopeptide repeat; Region: TPR_6; pfam13174
996285009079	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
996285009080	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285009081	ligand binding site [chemical binding]; other site
996285009082	translocation protein TolB; Provisional; Region: tolB; PRK00178
996285009083	TolB amino-terminal domain; Region: TolB_N; pfam04052
996285009084	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
996285009085	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
996285009086	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
996285009087	TolA protein; Region: tolA_full; TIGR02794
996285009088	TolA protein; Region: tolA_full; TIGR02794
996285009089	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
996285009090	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
996285009091	TolR protein; Region: tolR; TIGR02801
996285009092	TolQ protein; Region: tolQ; TIGR02796
996285009093	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
996285009094	active site
996285009095	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
996285009096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285009097	Walker A motif; other site
996285009098	ATP binding site [chemical binding]; other site
996285009099	Walker B motif; other site
996285009100	arginine finger; other site
996285009101	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
996285009102	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
996285009103	RuvA N terminal domain; Region: RuvA_N; pfam01330
996285009104	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
996285009105	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
996285009106	active site
996285009107	putative DNA-binding cleft [nucleotide binding]; other site
996285009108	dimer interface [polypeptide binding]; other site
996285009109	hypothetical protein; Validated; Region: PRK00110
996285009110	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
996285009111	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
996285009112	anticodon binding site; other site
996285009113	dimer interface [polypeptide binding]; other site
996285009114	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
996285009115	homodimer interface [polypeptide binding]; other site
996285009116	motif 1; other site
996285009117	active site
996285009118	motif 2; other site
996285009119	GAD domain; Region: GAD; pfam02938
996285009120	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996285009121	active site
996285009122	motif 3; other site
996285009123	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
996285009124	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
996285009125	dimerization interface [polypeptide binding]; other site
996285009126	DPS ferroxidase diiron center [ion binding]; other site
996285009127	ion pore; other site
996285009128	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996285009129	DNA-binding site [nucleotide binding]; DNA binding site
996285009130	RNA-binding motif; other site
996285009131	SlyX; Region: SlyX; cl01090
996285009132	HIT domain; Region: HIT; pfam01230
996285009133	nucleotide binding site/active site [active]
996285009134	HIT family signature motif; other site
996285009135	catalytic residue [active]
996285009136	outer membrane porin, OprD family; Region: OprD; pfam03573
996285009137	Transposase domain (DUF772); Region: DUF772; pfam05598
996285009138	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285009139	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285009140	outer membrane porin, OprD family; Region: OprD; pfam03573
996285009141	Transposase domain (DUF772); Region: DUF772; pfam05598
996285009142	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285009143	Protein of unknown function (DUF 659); Region: DUF659; pfam04937
996285009144	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285009145	Protein of unknown function, DUF; Region: DUF411; cl01142
996285009146	putative transposase OrfB; Reviewed; Region: PHA02517
996285009147	HTH-like domain; Region: HTH_21; pfam13276
996285009148	Integrase core domain; Region: rve; pfam00665
996285009149	Integrase core domain; Region: rve_3; pfam13683
996285009150	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
996285009151	Multicopper oxidase; Region: Cu-oxidase; pfam00394
996285009152	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
996285009153	prolyl-tRNA synthetase; Provisional; Region: PRK09194
996285009154	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
996285009155	dimer interface [polypeptide binding]; other site
996285009156	motif 1; other site
996285009157	active site
996285009158	motif 2; other site
996285009159	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
996285009160	putative deacylase active site [active]
996285009161	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
996285009162	active site
996285009163	motif 3; other site
996285009164	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
996285009165	anticodon binding site; other site
996285009166	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
996285009167	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285009168	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285009169	catalytic residue [active]
996285009170	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
996285009171	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996285009172	catalytic residues [active]
996285009173	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
996285009174	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
996285009175	ArsC family; Region: ArsC; pfam03960
996285009176	catalytic residues [active]
996285009177	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
996285009178	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
996285009179	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
996285009180	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
996285009181	DNA replication initiation factor; Validated; Region: PRK05642
996285009182	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
996285009183	Domain of unknown function DUF20; Region: UPF0118; pfam01594
996285009184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
996285009185	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
996285009186	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
996285009187	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
996285009188	dimerization interface [polypeptide binding]; other site
996285009189	putative ATP binding site [chemical binding]; other site
996285009190	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
996285009191	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
996285009192	active site
996285009193	substrate binding site [chemical binding]; other site
996285009194	cosubstrate binding site; other site
996285009195	catalytic site [active]
996285009196	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
996285009197	Predicted membrane protein [Function unknown]; Region: COG3650
996285009198	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
996285009199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285009200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285009201	homodimer interface [polypeptide binding]; other site
996285009202	catalytic residue [active]
996285009203	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
996285009204	catalytic residues [active]
996285009205	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
996285009206	ArsC family; Region: ArsC; pfam03960
996285009207	putative catalytic residues [active]
996285009208	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
996285009209	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
996285009210	putative trimer interface [polypeptide binding]; other site
996285009211	putative CoA binding site [chemical binding]; other site
996285009212	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
996285009213	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
996285009214	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285009215	catalytic residue [active]
996285009216	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
996285009217	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
996285009218	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
996285009219	dimer interface [polypeptide binding]; other site
996285009220	active site
996285009221	CoA binding pocket [chemical binding]; other site
996285009222	Cytochrome c [Energy production and conversion]; Region: COG3258
996285009223	Cytochrome c; Region: Cytochrom_C; pfam00034
996285009224	Cytochrome c; Region: Cytochrom_C; cl11414
996285009225	Cytochrome c; Region: Cytochrom_C; cl11414
996285009226	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
996285009227	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
996285009228	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
996285009229	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
996285009230	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
996285009231	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
996285009232	putative deacylase active site [active]
996285009233	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
996285009234	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
996285009235	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
996285009236	THF binding site; other site
996285009237	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
996285009238	substrate binding site [chemical binding]; other site
996285009239	THF binding site; other site
996285009240	zinc-binding site [ion binding]; other site
996285009241	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
996285009242	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
996285009243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285009244	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
996285009245	putative dimerization interface [polypeptide binding]; other site
996285009246	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
996285009247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285009248	NAD(P) binding site [chemical binding]; other site
996285009249	active site
996285009250	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
996285009251	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285009252	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285009253	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
996285009254	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285009255	DNA binding residues [nucleotide binding]
996285009256	dimerization interface [polypeptide binding]; other site
996285009257	curli assembly protein CsgE; Provisional; Region: PRK10386
996285009258	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
996285009259	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
996285009260	Curlin associated repeat; Region: Curlin_rpt; pfam07012
996285009261	Curlin associated repeat; Region: Curlin_rpt; pfam07012
996285009262	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285009263	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
996285009264	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
996285009265	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
996285009266	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285009267	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
996285009268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285009269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285009270	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285009271	dimerization interface [polypeptide binding]; other site
996285009272	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
996285009273	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
996285009274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285009275	S-adenosylmethionine binding site [chemical binding]; other site
996285009276	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
996285009277	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996285009278	Beta-Casp domain; Region: Beta-Casp; smart01027
996285009279	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
996285009280	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
996285009281	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285009282	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
996285009283	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
996285009284	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
996285009285	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
996285009286	putative NAD(P) binding site [chemical binding]; other site
996285009287	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
996285009288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285009289	Walker A motif; other site
996285009290	ATP binding site [chemical binding]; other site
996285009291	Walker B motif; other site
996285009292	arginine finger; other site
996285009293	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285009294	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
996285009295	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
996285009296	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
996285009297	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
996285009298	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
996285009299	tetramer interface [polypeptide binding]; other site
996285009300	TPP-binding site [chemical binding]; other site
996285009301	heterodimer interface [polypeptide binding]; other site
996285009302	phosphorylation loop region [posttranslational modification]
996285009303	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
996285009304	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
996285009305	putative NAD(P) binding site [chemical binding]; other site
996285009306	catalytic Zn binding site [ion binding]; other site
996285009307	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
996285009308	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
996285009309	alpha subunit interface [polypeptide binding]; other site
996285009310	TPP binding site [chemical binding]; other site
996285009311	heterodimer interface [polypeptide binding]; other site
996285009312	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
996285009313	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285009314	E3 interaction surface; other site
996285009315	lipoyl attachment site [posttranslational modification]; other site
996285009316	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
996285009317	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
996285009318	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
996285009319	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
996285009320	Trp docking motif [polypeptide binding]; other site
996285009321	cytochrome domain interface [polypeptide binding]; other site
996285009322	active site
996285009323	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
996285009324	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
996285009325	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285009326	membrane-bound complex binding site; other site
996285009327	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285009328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285009329	dimer interface [polypeptide binding]; other site
996285009330	conserved gate region; other site
996285009331	putative PBP binding loops; other site
996285009332	ABC-ATPase subunit interface; other site
996285009333	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
996285009334	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
996285009335	Walker A/P-loop; other site
996285009336	ATP binding site [chemical binding]; other site
996285009337	Q-loop/lid; other site
996285009338	ABC transporter signature motif; other site
996285009339	Walker B; other site
996285009340	D-loop; other site
996285009341	H-loop/switch region; other site
996285009342	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
996285009343	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285009344	DNA-binding site [nucleotide binding]; DNA binding site
996285009345	UTRA domain; Region: UTRA; pfam07702
996285009346	putative oxidoreductase; Provisional; Region: PRK08275
996285009347	L-aspartate oxidase; Provisional; Region: PRK06175
996285009348	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
996285009349	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
996285009350	HEAT repeats; Region: HEAT_2; pfam13646
996285009351	HEAT repeats; Region: HEAT_2; pfam13646
996285009352	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
996285009353	HEAT repeats; Region: HEAT_2; pfam13646
996285009354	protein binding surface [polypeptide binding]; other site
996285009355	Ferredoxin [Energy production and conversion]; Region: COG1146
996285009356	4Fe-4S binding domain; Region: Fer4; cl02805
996285009357	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
996285009358	Protein of unknown function (DUF971); Region: DUF971; pfam06155
996285009359	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
996285009360	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
996285009361	FAD binding pocket [chemical binding]; other site
996285009362	FAD binding motif [chemical binding]; other site
996285009363	phosphate binding motif [ion binding]; other site
996285009364	beta-alpha-beta structure motif; other site
996285009365	NAD binding pocket [chemical binding]; other site
996285009366	TLC ATP/ADP transporter; Region: TLC; cl03940
996285009367	short chain dehydrogenase; Provisional; Region: PRK06197
996285009368	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
996285009369	putative NAD(P) binding site [chemical binding]; other site
996285009370	active site
996285009371	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285009372	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285009373	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
996285009374	putative effector binding pocket; other site
996285009375	putative dimerization interface [polypeptide binding]; other site
996285009376	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285009377	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
996285009378	putative C-terminal domain interface [polypeptide binding]; other site
996285009379	putative GSH binding site (G-site) [chemical binding]; other site
996285009380	putative dimer interface [polypeptide binding]; other site
996285009381	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
996285009382	putative N-terminal domain interface [polypeptide binding]; other site
996285009383	putative dimer interface [polypeptide binding]; other site
996285009384	putative substrate binding pocket (H-site) [chemical binding]; other site
996285009385	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285009386	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
996285009387	active site
996285009388	metal binding site [ion binding]; metal-binding site
996285009389	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285009390	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285009391	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
996285009392	putative effector binding pocket; other site
996285009393	putative dimerization interface [polypeptide binding]; other site
996285009394	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
996285009395	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
996285009396	Sulfate transporter family; Region: Sulfate_transp; pfam00916
996285009397	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
996285009398	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
996285009399	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
996285009400	Acid Phosphatase; Region: Acid_PPase; cl17256
996285009401	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
996285009402	PAS domain S-box; Region: sensory_box; TIGR00229
996285009403	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285009404	putative active site [active]
996285009405	heme pocket [chemical binding]; other site
996285009406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285009407	dimer interface [polypeptide binding]; other site
996285009408	phosphorylation site [posttranslational modification]
996285009409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285009410	ATP binding site [chemical binding]; other site
996285009411	Mg2+ binding site [ion binding]; other site
996285009412	G-X-G motif; other site
996285009413	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285009414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285009415	active site
996285009416	phosphorylation site [posttranslational modification]
996285009417	intermolecular recognition site; other site
996285009418	dimerization interface [polypeptide binding]; other site
996285009419	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
996285009420	C factor cell-cell signaling protein; Provisional; Region: PRK09009
996285009421	NADP binding site [chemical binding]; other site
996285009422	homodimer interface [polypeptide binding]; other site
996285009423	active site
996285009424	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
996285009425	ABC1 family; Region: ABC1; cl17513
996285009426	circadian clock protein KaiC; Reviewed; Region: PRK09302
996285009427	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285009428	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285009429	Walker A motif; other site
996285009430	Walker A motif; other site
996285009431	ATP binding site [chemical binding]; other site
996285009432	Walker B motif; other site
996285009433	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285009434	Walker A motif; other site
996285009435	ATP binding site [chemical binding]; other site
996285009436	Walker B motif; other site
996285009437	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285009438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285009439	dimer interface [polypeptide binding]; other site
996285009440	phosphorylation site [posttranslational modification]
996285009441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285009442	ATP binding site [chemical binding]; other site
996285009443	Mg2+ binding site [ion binding]; other site
996285009444	G-X-G motif; other site
996285009445	Response regulator receiver domain; Region: Response_reg; pfam00072
996285009446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285009447	active site
996285009448	phosphorylation site [posttranslational modification]
996285009449	intermolecular recognition site; other site
996285009450	dimerization interface [polypeptide binding]; other site
996285009451	KTSC domain; Region: KTSC; pfam13619
996285009452	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996285009453	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996285009454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285009455	Walker A/P-loop; other site
996285009456	ATP binding site [chemical binding]; other site
996285009457	Q-loop/lid; other site
996285009458	ABC transporter signature motif; other site
996285009459	Walker B; other site
996285009460	D-loop; other site
996285009461	H-loop/switch region; other site
996285009462	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
996285009463	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
996285009464	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285009465	UDP-galactopyranose mutase; Region: GLF; pfam03275
996285009466	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
996285009467	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285009468	putative homodimer interface [polypeptide binding]; other site
996285009469	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
996285009470	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
996285009471	NAD binding site [chemical binding]; other site
996285009472	homodimer interface [polypeptide binding]; other site
996285009473	active site
996285009474	substrate binding site [chemical binding]; other site
996285009475	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
996285009476	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
996285009477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285009478	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285009479	dimerization interface [polypeptide binding]; other site
996285009480	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
996285009481	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
996285009482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285009483	catalytic residue [active]
996285009484	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
996285009485	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
996285009486	substrate binding site [chemical binding]; other site
996285009487	active site
996285009488	catalytic residues [active]
996285009489	heterodimer interface [polypeptide binding]; other site
996285009490	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
996285009491	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
996285009492	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
996285009493	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996285009494	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
996285009495	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
996285009496	NMT1/THI5 like; Region: NMT1; pfam09084
996285009497	substrate binding pocket [chemical binding]; other site
996285009498	membrane-bound complex binding site; other site
996285009499	hinge residues; other site
996285009500	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
996285009501	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
996285009502	Walker A/P-loop; other site
996285009503	ATP binding site [chemical binding]; other site
996285009504	Q-loop/lid; other site
996285009505	ABC transporter signature motif; other site
996285009506	Walker B; other site
996285009507	D-loop; other site
996285009508	H-loop/switch region; other site
996285009509	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285009510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285009511	putative PBP binding loops; other site
996285009512	dimer interface [polypeptide binding]; other site
996285009513	ABC-ATPase subunit interface; other site
996285009514	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
996285009515	nucleoside/Zn binding site; other site
996285009516	dimer interface [polypeptide binding]; other site
996285009517	catalytic motif [active]
996285009518	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
996285009519	classical (c) SDRs; Region: SDR_c; cd05233
996285009520	NAD(P) binding site [chemical binding]; other site
996285009521	active site
996285009522	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
996285009523	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
996285009524	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285009525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285009526	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
996285009527	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
996285009528	Walker A/P-loop; other site
996285009529	ATP binding site [chemical binding]; other site
996285009530	Q-loop/lid; other site
996285009531	ABC transporter signature motif; other site
996285009532	Walker B; other site
996285009533	D-loop; other site
996285009534	H-loop/switch region; other site
996285009535	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
996285009536	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285009537	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
996285009538	TM-ABC transporter signature motif; other site
996285009539	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285009540	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
996285009541	TM-ABC transporter signature motif; other site
996285009542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
996285009543	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
996285009544	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
996285009545	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
996285009546	DNA topoisomerase III; Provisional; Region: PRK07726
996285009547	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
996285009548	active site
996285009549	putative interdomain interaction site [polypeptide binding]; other site
996285009550	putative metal-binding site [ion binding]; other site
996285009551	putative nucleotide binding site [chemical binding]; other site
996285009552	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
996285009553	domain I; other site
996285009554	DNA binding groove [nucleotide binding]
996285009555	phosphate binding site [ion binding]; other site
996285009556	domain II; other site
996285009557	domain III; other site
996285009558	nucleotide binding site [chemical binding]; other site
996285009559	catalytic site [active]
996285009560	domain IV; other site
996285009561	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
996285009562	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
996285009563	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
996285009564	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
996285009565	transmembrane helices; other site
996285009566	TrkA-C domain; Region: TrkA_C; pfam02080
996285009567	TrkA-C domain; Region: TrkA_C; pfam02080
996285009568	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
996285009569	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
996285009570	Nitrate and nitrite sensing; Region: NIT; pfam08376
996285009571	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285009572	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285009573	dimerization interface [polypeptide binding]; other site
996285009574	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285009575	dimer interface [polypeptide binding]; other site
996285009576	putative CheW interface [polypeptide binding]; other site
996285009577	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
996285009578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285009579	putative substrate translocation pore; other site
996285009580	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
996285009581	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
996285009582	nucleophilic elbow; other site
996285009583	catalytic triad; other site
996285009584	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
996285009585	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
996285009586	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
996285009587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285009588	dimerization interface [polypeptide binding]; other site
996285009589	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285009590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285009591	dimer interface [polypeptide binding]; other site
996285009592	putative CheW interface [polypeptide binding]; other site
996285009593	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
996285009594	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
996285009595	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
996285009596	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285009597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285009598	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285009599	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285009600	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285009601	dimerization interface [polypeptide binding]; other site
996285009602	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285009603	dimer interface [polypeptide binding]; other site
996285009604	putative CheW interface [polypeptide binding]; other site
996285009605	Protein of unknown function (DUF445); Region: DUF445; pfam04286
996285009606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285009607	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
996285009608	Walker A/P-loop; other site
996285009609	ATP binding site [chemical binding]; other site
996285009610	Q-loop/lid; other site
996285009611	ABC transporter signature motif; other site
996285009612	Walker B; other site
996285009613	D-loop; other site
996285009614	H-loop/switch region; other site
996285009615	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285009616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285009617	dimer interface [polypeptide binding]; other site
996285009618	conserved gate region; other site
996285009619	putative PBP binding loops; other site
996285009620	ABC-ATPase subunit interface; other site
996285009621	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285009622	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285009623	membrane-bound complex binding site; other site
996285009624	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
996285009625	HIT family signature motif; other site
996285009626	catalytic residue [active]
996285009627	glutamate carboxypeptidase; Reviewed; Region: PRK06133
996285009628	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
996285009629	metal binding site [ion binding]; metal-binding site
996285009630	dimer interface [polypeptide binding]; other site
996285009631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
996285009632	MOSC domain; Region: MOSC; pfam03473
996285009633	Predicted periplasmic protein [Function unknown]; Region: COG3904
996285009634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
996285009635	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
996285009636	dimer interface [polypeptide binding]; other site
996285009637	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285009638	Predicted membrane protein [Function unknown]; Region: COG3503
996285009639	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
996285009640	Citrate transporter; Region: CitMHS; pfam03600
996285009641	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285009642	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
996285009643	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
996285009644	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996285009645	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996285009646	hypothetical protein; Provisional; Region: PRK11171
996285009647	Cupin domain; Region: Cupin_2; pfam07883
996285009648	Cupin domain; Region: Cupin_2; pfam07883
996285009649	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
996285009650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285009651	S-adenosylmethionine binding site [chemical binding]; other site
996285009652	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
996285009653	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285009654	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
996285009655	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
996285009656	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
996285009657	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
996285009658	Protein phosphatase 2C; Region: PP2C; pfam00481
996285009659	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
996285009660	active site
996285009661	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
996285009662	Catalytic domain of Protein Kinases; Region: PKc; cd00180
996285009663	active site
996285009664	ATP binding site [chemical binding]; other site
996285009665	substrate binding site [chemical binding]; other site
996285009666	activation loop (A-loop); other site
996285009667	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
996285009668	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
996285009669	phosphopeptide binding site; other site
996285009670	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
996285009671	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
996285009672	phosphopeptide binding site; other site
996285009673	Predicted permeases [General function prediction only]; Region: RarD; COG2962
996285009674	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
996285009675	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285009676	ATP binding site [chemical binding]; other site
996285009677	putative Mg++ binding site [ion binding]; other site
996285009678	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285009679	nucleotide binding region [chemical binding]; other site
996285009680	ATP-binding site [chemical binding]; other site
996285009681	Helicase associated domain (HA2); Region: HA2; pfam04408
996285009682	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
996285009683	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
996285009684	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
996285009685	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
996285009686	PA/protease or protease-like domain interface [polypeptide binding]; other site
996285009687	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
996285009688	Peptidase family M28; Region: Peptidase_M28; pfam04389
996285009689	active site
996285009690	metal binding site [ion binding]; metal-binding site
996285009691	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
996285009692	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285009693	dimerization interface [polypeptide binding]; other site
996285009694	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285009695	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285009696	dimer interface [polypeptide binding]; other site
996285009697	putative CheW interface [polypeptide binding]; other site
996285009698	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
996285009699	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
996285009700	acyl-activating enzyme (AAE) consensus motif; other site
996285009701	putative AMP binding site [chemical binding]; other site
996285009702	putative active site [active]
996285009703	putative CoA binding site [chemical binding]; other site
996285009704	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
996285009705	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
996285009706	acyl-activating enzyme (AAE) consensus motif; other site
996285009707	putative AMP binding site [chemical binding]; other site
996285009708	putative active site [active]
996285009709	putative CoA binding site [chemical binding]; other site
996285009710	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
996285009711	dimer interaction site [polypeptide binding]; other site
996285009712	substrate-binding tunnel; other site
996285009713	active site
996285009714	catalytic site [active]
996285009715	substrate binding site [chemical binding]; other site
996285009716	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
996285009717	carbohydrate binding site [chemical binding]; other site
996285009718	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
996285009719	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
996285009720	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
996285009721	Ca binding site [ion binding]; other site
996285009722	active site
996285009723	catalytic site [active]
996285009724	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
996285009725	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
996285009726	ATP-dependent helicase HepA; Validated; Region: PRK04914
996285009727	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285009728	ATP binding site [chemical binding]; other site
996285009729	putative Mg++ binding site [ion binding]; other site
996285009730	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285009731	nucleotide binding region [chemical binding]; other site
996285009732	ATP-binding site [chemical binding]; other site
996285009733	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
996285009734	putative chaperone; Provisional; Region: PRK11678
996285009735	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
996285009736	nucleotide binding site [chemical binding]; other site
996285009737	putative NEF/HSP70 interaction site [polypeptide binding]; other site
996285009738	SBD interface [polypeptide binding]; other site
996285009739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285009740	putative substrate translocation pore; other site
996285009741	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285009742	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
996285009743	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
996285009744	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996285009745	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
996285009746	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
996285009747	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285009748	substrate binding pocket [chemical binding]; other site
996285009749	membrane-bound complex binding site; other site
996285009750	hinge residues; other site
996285009751	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
996285009752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285009753	Walker A/P-loop; other site
996285009754	ATP binding site [chemical binding]; other site
996285009755	Q-loop/lid; other site
996285009756	ABC transporter signature motif; other site
996285009757	Walker B; other site
996285009758	D-loop; other site
996285009759	H-loop/switch region; other site
996285009760	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
996285009761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285009762	dimer interface [polypeptide binding]; other site
996285009763	conserved gate region; other site
996285009764	putative PBP binding loops; other site
996285009765	ABC-ATPase subunit interface; other site
996285009766	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
996285009767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
996285009768	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
996285009769	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
996285009770	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
996285009771	dimerization interface [polypeptide binding]; other site
996285009772	ligand binding site [chemical binding]; other site
996285009773	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285009774	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
996285009775	TM-ABC transporter signature motif; other site
996285009776	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
996285009777	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
996285009778	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
996285009779	TM-ABC transporter signature motif; other site
996285009780	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
996285009781	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
996285009782	Walker A/P-loop; other site
996285009783	ATP binding site [chemical binding]; other site
996285009784	Q-loop/lid; other site
996285009785	ABC transporter signature motif; other site
996285009786	Walker B; other site
996285009787	D-loop; other site
996285009788	H-loop/switch region; other site
996285009789	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
996285009790	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
996285009791	Walker A/P-loop; other site
996285009792	ATP binding site [chemical binding]; other site
996285009793	Q-loop/lid; other site
996285009794	ABC transporter signature motif; other site
996285009795	Walker B; other site
996285009796	D-loop; other site
996285009797	H-loop/switch region; other site
996285009798	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
996285009799	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
996285009800	META domain; Region: META; pfam03724
996285009801	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
996285009802	active site
996285009803	DNA polymerase IV; Validated; Region: PRK02406
996285009804	DNA binding site [nucleotide binding]
996285009805	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
996285009806	active site
996285009807	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
996285009808	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
996285009809	HIGH motif; other site
996285009810	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
996285009811	active site
996285009812	KMSKS motif; other site
996285009813	excinuclease ABC subunit B; Provisional; Region: PRK05298
996285009814	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285009815	ATP binding site [chemical binding]; other site
996285009816	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285009817	nucleotide binding region [chemical binding]; other site
996285009818	ATP-binding site [chemical binding]; other site
996285009819	Ultra-violet resistance protein B; Region: UvrB; pfam12344
996285009820	UvrB/uvrC motif; Region: UVR; pfam02151
996285009821	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
996285009822	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285009823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285009824	homodimer interface [polypeptide binding]; other site
996285009825	catalytic residue [active]
996285009826	VanZ like family; Region: VanZ; cl01971
996285009827	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
996285009828	putative GSH binding site [chemical binding]; other site
996285009829	catalytic residues [active]
996285009830	ornithine carbamoyltransferase; Provisional; Region: PRK00779
996285009831	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
996285009832	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
996285009833	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
996285009834	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
996285009835	Walker A/P-loop; other site
996285009836	ATP binding site [chemical binding]; other site
996285009837	Q-loop/lid; other site
996285009838	ABC transporter signature motif; other site
996285009839	Walker B; other site
996285009840	D-loop; other site
996285009841	H-loop/switch region; other site
996285009842	TOBE domain; Region: TOBE_2; pfam08402
996285009843	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
996285009844	nucleoside/Zn binding site; other site
996285009845	dimer interface [polypeptide binding]; other site
996285009846	catalytic motif [active]
996285009847	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
996285009848	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
996285009849	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
996285009850	GMP synthase; Reviewed; Region: guaA; PRK00074
996285009851	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
996285009852	AMP/PPi binding site [chemical binding]; other site
996285009853	candidate oxyanion hole; other site
996285009854	catalytic triad [active]
996285009855	potential glutamine specificity residues [chemical binding]; other site
996285009856	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
996285009857	ATP Binding subdomain [chemical binding]; other site
996285009858	Ligand Binding sites [chemical binding]; other site
996285009859	Dimerization subdomain; other site
996285009860	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
996285009861	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
996285009862	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
996285009863	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
996285009864	active site
996285009865	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
996285009866	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
996285009867	generic binding surface II; other site
996285009868	generic binding surface I; other site
996285009869	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
996285009870	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285009871	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
996285009872	Isochorismatase family; Region: Isochorismatase; pfam00857
996285009873	catalytic triad [active]
996285009874	dimer interface [polypeptide binding]; other site
996285009875	conserved cis-peptide bond; other site
996285009876	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
996285009877	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285009878	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285009879	N-terminal plug; other site
996285009880	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
996285009881	ligand-binding site [chemical binding]; other site
996285009882	2-isopropylmalate synthase; Validated; Region: PRK03739
996285009883	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
996285009884	active site
996285009885	catalytic residues [active]
996285009886	metal binding site [ion binding]; metal-binding site
996285009887	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
996285009888	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
996285009889	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
996285009890	putative NAD(P) binding site [chemical binding]; other site
996285009891	putative substrate binding site [chemical binding]; other site
996285009892	catalytic Zn binding site [ion binding]; other site
996285009893	structural Zn binding site [ion binding]; other site
996285009894	dimer interface [polypeptide binding]; other site
996285009895	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
996285009896	EamA-like transporter family; Region: EamA; pfam00892
996285009897	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
996285009898	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
996285009899	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
996285009900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285009901	S-adenosylmethionine binding site [chemical binding]; other site
996285009902	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
996285009903	C-N hydrolase family amidase; Provisional; Region: PRK10438
996285009904	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
996285009905	putative active site [active]
996285009906	catalytic triad [active]
996285009907	dimer interface [polypeptide binding]; other site
996285009908	multimer interface [polypeptide binding]; other site
996285009909	methionine aminotransferase; Validated; Region: PRK09082
996285009910	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285009911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285009912	homodimer interface [polypeptide binding]; other site
996285009913	catalytic residue [active]
996285009914	serine acetyltransferase; Provisional; Region: cysE; PRK11132
996285009915	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
996285009916	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
996285009917	trimer interface [polypeptide binding]; other site
996285009918	active site
996285009919	substrate binding site [chemical binding]; other site
996285009920	CoA binding site [chemical binding]; other site
996285009921	GTP-binding protein Der; Reviewed; Region: PRK00093
996285009922	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
996285009923	G1 box; other site
996285009924	GTP/Mg2+ binding site [chemical binding]; other site
996285009925	Switch I region; other site
996285009926	G2 box; other site
996285009927	Switch II region; other site
996285009928	G3 box; other site
996285009929	G4 box; other site
996285009930	G5 box; other site
996285009931	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
996285009932	G1 box; other site
996285009933	GTP/Mg2+ binding site [chemical binding]; other site
996285009934	Switch I region; other site
996285009935	G2 box; other site
996285009936	G3 box; other site
996285009937	Switch II region; other site
996285009938	G4 box; other site
996285009939	G5 box; other site
996285009940	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
996285009941	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
996285009942	Trp docking motif [polypeptide binding]; other site
996285009943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
996285009944	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
996285009945	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
996285009946	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
996285009947	dimer interface [polypeptide binding]; other site
996285009948	motif 1; other site
996285009949	active site
996285009950	motif 2; other site
996285009951	motif 3; other site
996285009952	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
996285009953	anticodon binding site; other site
996285009954	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
996285009955	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
996285009956	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
996285009957	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
996285009958	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
996285009959	non-specific DNA binding site [nucleotide binding]; other site
996285009960	salt bridge; other site
996285009961	sequence-specific DNA binding site [nucleotide binding]; other site
996285009962	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
996285009963	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
996285009964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285009965	binding surface
996285009966	TPR motif; other site
996285009967	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285009968	binding surface
996285009969	TPR motif; other site
996285009970	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
996285009971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285009972	FeS/SAM binding site; other site
996285009973	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
996285009974	active site
996285009975	multimer interface [polypeptide binding]; other site
996285009976	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
996285009977	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
996285009978	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285009979	catalytic loop [active]
996285009980	iron binding site [ion binding]; other site
996285009981	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
996285009982	chaperone protein HscA; Provisional; Region: hscA; PRK05183
996285009983	putative NEF/HSP70 interaction site [polypeptide binding]; other site
996285009984	nucleotide binding site [chemical binding]; other site
996285009985	SBD interface [polypeptide binding]; other site
996285009986	co-chaperone HscB; Provisional; Region: hscB; PRK00294
996285009987	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
996285009988	HSP70 interaction site [polypeptide binding]; other site
996285009989	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
996285009990	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
996285009991	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
996285009992	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
996285009993	trimerization site [polypeptide binding]; other site
996285009994	active site
996285009995	cysteine desulfurase; Provisional; Region: PRK14012
996285009996	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
996285009997	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
996285009998	catalytic residue [active]
996285009999	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
996285010000	Rrf2 family protein; Region: rrf2_super; TIGR00738
996285010001	serine O-acetyltransferase; Region: cysE; TIGR01172
996285010002	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
996285010003	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
996285010004	trimer interface [polypeptide binding]; other site
996285010005	active site
996285010006	substrate binding site [chemical binding]; other site
996285010007	CoA binding site [chemical binding]; other site
996285010008	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
996285010009	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
996285010010	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
996285010011	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
996285010012	active site
996285010013	dimerization interface [polypeptide binding]; other site
996285010014	hypothetical protein; Provisional; Region: PRK11280
996285010015	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
996285010016	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
996285010017	Protein export membrane protein; Region: SecD_SecF; pfam02355
996285010018	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
996285010019	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
996285010020	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
996285010021	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
996285010022	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
996285010023	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
996285010024	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
996285010025	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
996285010026	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
996285010027	potential protein location (conserved hypothetical protein [Pseudomonas stutzeri DSM 4166]) that overlaps RNA (tRNA-L)
996285010028	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996285010029	DNA-binding site [nucleotide binding]; DNA binding site
996285010030	RNA-binding motif; other site
996285010031	RDD family; Region: RDD; pfam06271
996285010032	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
996285010033	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
996285010034	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
996285010035	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
996285010036	multifunctional aminopeptidase A; Provisional; Region: PRK00913
996285010037	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
996285010038	interface (dimer of trimers) [polypeptide binding]; other site
996285010039	Substrate-binding/catalytic site; other site
996285010040	Zn-binding sites [ion binding]; other site
996285010041	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
996285010042	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
996285010043	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
996285010044	HIGH motif; other site
996285010045	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
996285010046	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
996285010047	active site
996285010048	KMSKS motif; other site
996285010049	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
996285010050	tRNA binding surface [nucleotide binding]; other site
996285010051	anticodon binding site; other site
996285010052	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
996285010053	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
996285010054	NHAD transporter family protein; Provisional; Region: PLN00137
996285010055	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
996285010056	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
996285010057	transmembrane helices; other site
996285010058	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
996285010059	TrkA-C domain; Region: TrkA_C; pfam02080
996285010060	TrkA-C domain; Region: TrkA_C; pfam02080
996285010061	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
996285010062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285010063	putative substrate translocation pore; other site
996285010064	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
996285010065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285010066	S-adenosylmethionine binding site [chemical binding]; other site
996285010067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285010068	putative substrate translocation pore; other site
996285010069	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285010070	nucleoid-associated protein NdpA; Validated; Region: PRK00378
996285010071	Nucleoid-associated protein [General function prediction only]; Region: COG3081
996285010072	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
996285010073	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
996285010074	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
996285010075	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285010076	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
996285010077	C-terminal domain interface [polypeptide binding]; other site
996285010078	GSH binding site (G-site) [chemical binding]; other site
996285010079	dimer interface [polypeptide binding]; other site
996285010080	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
996285010081	N-terminal domain interface [polypeptide binding]; other site
996285010082	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
996285010083	GIY-YIG motif/motif A; other site
996285010084	putative active site [active]
996285010085	putative metal binding site [ion binding]; other site
996285010086	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
996285010087	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285010088	substrate binding pocket [chemical binding]; other site
996285010089	membrane-bound complex binding site; other site
996285010090	hinge residues; other site
996285010091	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285010092	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285010093	catalytic residue [active]
996285010094	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
996285010095	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
996285010096	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285010097	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
996285010098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285010099	motif II; other site
996285010100	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
996285010101	C factor cell-cell signaling protein; Provisional; Region: PRK09009
996285010102	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
996285010103	NADP binding site [chemical binding]; other site
996285010104	homodimer interface [polypeptide binding]; other site
996285010105	active site
996285010106	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
996285010107	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
996285010108	active site
996285010109	putative substrate binding pocket [chemical binding]; other site
996285010110	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
996285010111	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
996285010112	putative ligand binding site [chemical binding]; other site
996285010113	oxidase reductase; Provisional; Region: PTZ00273
996285010114	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
996285010115	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
996285010116	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
996285010117	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285010118	catalytic loop [active]
996285010119	iron binding site [ion binding]; other site
996285010120	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
996285010121	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
996285010122	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
996285010123	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
996285010124	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
996285010125	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
996285010126	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
996285010127	XdhC Rossmann domain; Region: XdhC_C; pfam13478
996285010128	guanine deaminase; Provisional; Region: PRK09228
996285010129	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
996285010130	active site
996285010131	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
996285010132	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
996285010133	metal binding site [ion binding]; metal-binding site
996285010134	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
996285010135	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
996285010136	ABC-ATPase subunit  interface; other site
996285010137	dimer interface [polypeptide binding]; other site
996285010138	putative PBP binding regions; other site
996285010139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285010140	Walker A/P-loop; other site
996285010141	ATP binding site [chemical binding]; other site
996285010142	Q-loop/lid; other site
996285010143	ABC transporter signature motif; other site
996285010144	Walker B; other site
996285010145	D-loop; other site
996285010146	H-loop/switch region; other site
996285010147	Transcriptional regulators [Transcription]; Region: GntR; COG1802
996285010148	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285010149	DNA-binding site [nucleotide binding]; DNA binding site
996285010150	FCD domain; Region: FCD; pfam07729
996285010151	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
996285010152	Sulfate transporter family; Region: Sulfate_transp; pfam00916
996285010153	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285010154	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
996285010155	active site
996285010156	homotetramer interface [polypeptide binding]; other site
996285010157	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
996285010158	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
996285010159	active site
996285010160	catalytic site [active]
996285010161	tetramer interface [polypeptide binding]; other site
996285010162	OHCU decarboxylase; Region: UHCUDC; TIGR03164
996285010163	allantoicase; Provisional; Region: PRK13257
996285010164	Allantoicase repeat; Region: Allantoicase; pfam03561
996285010165	Allantoicase repeat; Region: Allantoicase; pfam03561
996285010166	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
996285010167	ureidoglycolate hydrolase; Provisional; Region: PRK03606
996285010168	Predicted membrane protein [Function unknown]; Region: COG3748
996285010169	Protein of unknown function (DUF989); Region: DUF989; pfam06181
996285010170	Cytochrome c; Region: Cytochrom_C; pfam00034
996285010171	xanthine permease; Region: pbuX; TIGR03173
996285010172	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
996285010173	TrkA-N domain; Region: TrkA_N; pfam02254
996285010174	xanthine permease; Region: pbuX; TIGR03173
996285010175	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
996285010176	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
996285010177	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285010178	dimerization interface [polypeptide binding]; other site
996285010179	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285010180	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285010181	dimer interface [polypeptide binding]; other site
996285010182	putative CheW interface [polypeptide binding]; other site
996285010183	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
996285010184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285010185	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
996285010186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285010187	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
996285010188	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285010189	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
996285010190	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
996285010191	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
996285010192	GAF domain; Region: GAF_2; pfam13185
996285010193	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285010194	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
996285010195	putative catalytic site [active]
996285010196	putative phosphate binding site [ion binding]; other site
996285010197	active site
996285010198	metal binding site A [ion binding]; metal-binding site
996285010199	DNA binding site [nucleotide binding]
996285010200	putative AP binding site [nucleotide binding]; other site
996285010201	putative metal binding site B [ion binding]; other site
996285010202	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
996285010203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285010204	dimer interface [polypeptide binding]; other site
996285010205	phosphorylation site [posttranslational modification]
996285010206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285010207	ATP binding site [chemical binding]; other site
996285010208	G-X-G motif; other site
996285010209	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
996285010210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285010211	active site
996285010212	phosphorylation site [posttranslational modification]
996285010213	intermolecular recognition site; other site
996285010214	dimerization interface [polypeptide binding]; other site
996285010215	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285010216	DNA binding site [nucleotide binding]
996285010217	Domain of unknown function (DUF336); Region: DUF336; pfam03928
996285010218	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
996285010219	active site
996285010220	homotetramer interface [polypeptide binding]; other site
996285010221	transcriptional activator TtdR; Provisional; Region: PRK09801
996285010222	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285010223	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285010224	putative effector binding pocket; other site
996285010225	dimerization interface [polypeptide binding]; other site
996285010226	glyoxylate carboligase; Provisional; Region: PRK11269
996285010227	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
996285010228	PYR/PP interface [polypeptide binding]; other site
996285010229	dimer interface [polypeptide binding]; other site
996285010230	TPP binding site [chemical binding]; other site
996285010231	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
996285010232	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
996285010233	TPP-binding site [chemical binding]; other site
996285010234	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
996285010235	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
996285010236	tartronate semialdehyde reductase; Provisional; Region: PRK15059
996285010237	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
996285010238	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
996285010239	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
996285010240	MOFRL family; Region: MOFRL; pfam05161
996285010241	pyruvate kinase; Provisional; Region: PRK06247
996285010242	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
996285010243	domain interfaces; other site
996285010244	active site
996285010245	Urea transporter; Region: UT; cl01829
996285010246	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
996285010247	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
996285010248	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
996285010249	heme-binding site [chemical binding]; other site
996285010250	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
996285010251	FAD binding pocket [chemical binding]; other site
996285010252	FAD binding motif [chemical binding]; other site
996285010253	phosphate binding motif [ion binding]; other site
996285010254	beta-alpha-beta structure motif; other site
996285010255	NAD binding pocket [chemical binding]; other site
996285010256	Heme binding  pocket [chemical binding]; other site
996285010257	General stress protein [General function prediction only]; Region: GsiB; COG3729
996285010258	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
996285010259	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
996285010260	active site
996285010261	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285010262	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285010263	metal binding site [ion binding]; metal-binding site
996285010264	active site
996285010265	I-site; other site
996285010266	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
996285010267	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
996285010268	active site
996285010269	catalytic triad [active]
996285010270	oxyanion hole [active]
996285010271	Autotransporter beta-domain; Region: Autotransporter; smart00869
996285010272	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
996285010273	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
996285010274	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
996285010275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285010276	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285010277	dimerization interface [polypeptide binding]; other site
996285010278	Lysine efflux permease [General function prediction only]; Region: COG1279
996285010279	superoxide dismutase; Provisional; Region: PRK10543
996285010280	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
996285010281	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
996285010282	biofilm formation regulator HmsP; Provisional; Region: PRK11829
996285010283	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285010284	metal binding site [ion binding]; metal-binding site
996285010285	active site
996285010286	I-site; other site
996285010287	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285010288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285010289	S-adenosylmethionine binding site [chemical binding]; other site
996285010290	E3 Ubiquitin ligase; Region: GIDE; pfam12483
996285010291	LemA family; Region: LemA; cl00742
996285010292	Imelysin; Region: Peptidase_M75; cl09159
996285010293	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
996285010294	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
996285010295	Imelysin; Region: Peptidase_M75; cl09159
996285010296	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
996285010297	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285010298	dimerization interface [polypeptide binding]; other site
996285010299	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285010300	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285010301	dimer interface [polypeptide binding]; other site
996285010302	putative CheW interface [polypeptide binding]; other site
996285010303	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
996285010304	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285010305	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285010306	multidrug efflux protein; Reviewed; Region: PRK09579
996285010307	Protein export membrane protein; Region: SecD_SecF; cl14618
996285010308	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
996285010309	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
996285010310	ring oligomerisation interface [polypeptide binding]; other site
996285010311	ATP/Mg binding site [chemical binding]; other site
996285010312	stacking interactions; other site
996285010313	hinge regions; other site
996285010314	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
996285010315	oligomerisation interface [polypeptide binding]; other site
996285010316	mobile loop; other site
996285010317	roof hairpin; other site
996285010318	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
996285010319	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
996285010320	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
996285010321	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
996285010322	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
996285010323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285010324	NAD(P) binding site [chemical binding]; other site
996285010325	active site
996285010326	Protein of unknown function, DUF481; Region: DUF481; pfam04338
996285010327	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
996285010328	DNA binding site [nucleotide binding]
996285010329	active site
996285010330	muropeptide transporter; Validated; Region: ampG; cl17669
996285010331	muropeptide transporter; Validated; Region: ampG; cl17669
996285010332	mechanosensitive channel MscS; Provisional; Region: PRK10334
996285010333	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285010334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
996285010335	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
996285010336	Response regulator receiver domain; Region: Response_reg; pfam00072
996285010337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285010338	active site
996285010339	phosphorylation site [posttranslational modification]
996285010340	intermolecular recognition site; other site
996285010341	dimerization interface [polypeptide binding]; other site
996285010342	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285010343	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285010344	metal binding site [ion binding]; metal-binding site
996285010345	active site
996285010346	I-site; other site
996285010347	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
996285010348	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
996285010349	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
996285010350	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285010351	dimerization interface [polypeptide binding]; other site
996285010352	PAS domain; Region: PAS; smart00091
996285010353	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
996285010354	putative active site [active]
996285010355	heme pocket [chemical binding]; other site
996285010356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285010357	dimer interface [polypeptide binding]; other site
996285010358	phosphorylation site [posttranslational modification]
996285010359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285010360	ATP binding site [chemical binding]; other site
996285010361	Mg2+ binding site [ion binding]; other site
996285010362	G-X-G motif; other site
996285010363	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
996285010364	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
996285010365	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
996285010366	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
996285010367	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
996285010368	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
996285010369	catalytic residue [active]
996285010370	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
996285010371	catalytic residues [active]
996285010372	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285010373	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285010374	peroxiredoxin; Region: AhpC; TIGR03137
996285010375	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
996285010376	dimer interface [polypeptide binding]; other site
996285010377	decamer (pentamer of dimers) interface [polypeptide binding]; other site
996285010378	catalytic triad [active]
996285010379	peroxidatic and resolving cysteines [active]
996285010380	hypothetical protein; Provisional; Region: PRK08999
996285010381	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
996285010382	active site
996285010383	8-oxo-dGMP binding site [chemical binding]; other site
996285010384	nudix motif; other site
996285010385	metal binding site [ion binding]; metal-binding site
996285010386	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
996285010387	thiamine phosphate binding site [chemical binding]; other site
996285010388	active site
996285010389	pyrophosphate binding site [ion binding]; other site
996285010390	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
996285010391	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285010392	putative C-terminal domain interface [polypeptide binding]; other site
996285010393	putative GSH binding site (G-site) [chemical binding]; other site
996285010394	putative dimer interface [polypeptide binding]; other site
996285010395	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
996285010396	putative N-terminal domain interface [polypeptide binding]; other site
996285010397	putative dimer interface [polypeptide binding]; other site
996285010398	putative substrate binding pocket (H-site) [chemical binding]; other site
996285010399	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
996285010400	heterotetramer interface [polypeptide binding]; other site
996285010401	active site pocket [active]
996285010402	cleavage site
996285010403	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
996285010404	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996285010405	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
996285010406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
996285010407	nucleotide binding region [chemical binding]; other site
996285010408	ATP-binding site [chemical binding]; other site
996285010409	SEC-C motif; Region: SEC-C; pfam02810
996285010410	Protein of unknown function (DUF721); Region: DUF721; cl02324
996285010411	YebG protein; Region: YebG; cl01217
996285010412	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
996285010413	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
996285010414	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285010415	DNA binding residues [nucleotide binding]
996285010416	dimerization interface [polypeptide binding]; other site
996285010417	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
996285010418	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
996285010419	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285010420	active site
996285010421	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285010422	active site
996285010423	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
996285010424	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
996285010425	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
996285010426	glutamate racemase; Provisional; Region: PRK00865
996285010427	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
996285010428	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
996285010429	ATP binding site [chemical binding]; other site
996285010430	substrate interface [chemical binding]; other site
996285010431	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
996285010432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285010433	peptide chain release factor 1; Validated; Region: prfA; PRK00591
996285010434	This domain is found in peptide chain release factors; Region: PCRF; smart00937
996285010435	RF-1 domain; Region: RF-1; pfam00472
996285010436	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
996285010437	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
996285010438	tRNA; other site
996285010439	putative tRNA binding site [nucleotide binding]; other site
996285010440	putative NADP binding site [chemical binding]; other site
996285010441	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
996285010442	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285010443	TPR motif; other site
996285010444	binding surface
996285010445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285010446	binding surface
996285010447	TPR motif; other site
996285010448	TPR repeat; Region: TPR_11; pfam13414
996285010449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285010450	binding surface
996285010451	TPR motif; other site
996285010452	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
996285010453	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
996285010454	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
996285010455	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
996285010456	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
996285010457	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
996285010458	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
996285010459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285010460	active site
996285010461	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
996285010462	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
996285010463	5S rRNA interface [nucleotide binding]; other site
996285010464	CTC domain interface [polypeptide binding]; other site
996285010465	L16 interface [polypeptide binding]; other site
996285010466	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
996285010467	putative active site [active]
996285010468	catalytic residue [active]
996285010469	GTP-binding protein YchF; Reviewed; Region: PRK09601
996285010470	YchF GTPase; Region: YchF; cd01900
996285010471	G1 box; other site
996285010472	GTP/Mg2+ binding site [chemical binding]; other site
996285010473	Switch I region; other site
996285010474	G2 box; other site
996285010475	Switch II region; other site
996285010476	G3 box; other site
996285010477	G4 box; other site
996285010478	G5 box; other site
996285010479	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
996285010480	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
996285010481	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285010482	TM-ABC transporter signature motif; other site
996285010483	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
996285010484	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285010485	TM-ABC transporter signature motif; other site
996285010486	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
996285010487	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
996285010488	putative ligand binding site [chemical binding]; other site
996285010489	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
996285010490	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
996285010491	Walker A/P-loop; other site
996285010492	ATP binding site [chemical binding]; other site
996285010493	Q-loop/lid; other site
996285010494	ABC transporter signature motif; other site
996285010495	Walker B; other site
996285010496	D-loop; other site
996285010497	H-loop/switch region; other site
996285010498	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
996285010499	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
996285010500	Walker A/P-loop; other site
996285010501	ATP binding site [chemical binding]; other site
996285010502	Q-loop/lid; other site
996285010503	ABC transporter signature motif; other site
996285010504	Walker B; other site
996285010505	D-loop; other site
996285010506	H-loop/switch region; other site
996285010507	potential frameshift: common BLAST hit: gi|146283534|ref|YP_001173687.1| porin
996285010508	outer membrane porin, OprD family; Region: OprD; pfam03573
996285010509	outer membrane porin, OprD family; Region: OprD; pfam03573
996285010510	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
996285010511	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
996285010512	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
996285010513	AMP-binding domain protein; Validated; Region: PRK08315
996285010514	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
996285010515	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
996285010516	acyl-activating enzyme (AAE) consensus motif; other site
996285010517	putative AMP binding site [chemical binding]; other site
996285010518	putative active site [active]
996285010519	putative CoA binding site [chemical binding]; other site
996285010520	UV-endonuclease UvdE; Region: UvdE; cl10036
996285010521	isovaleryl-CoA dehydrogenase; Region: PLN02519
996285010522	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
996285010523	substrate binding site [chemical binding]; other site
996285010524	FAD binding site [chemical binding]; other site
996285010525	catalytic base [active]
996285010526	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
996285010527	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
996285010528	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
996285010529	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
996285010530	substrate binding site [chemical binding]; other site
996285010531	oxyanion hole (OAH) forming residues; other site
996285010532	trimer interface [polypeptide binding]; other site
996285010533	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
996285010534	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996285010535	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
996285010536	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
996285010537	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996285010538	carboxyltransferase (CT) interaction site; other site
996285010539	biotinylation site [posttranslational modification]; other site
996285010540	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
996285010541	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
996285010542	active site
996285010543	catalytic residues [active]
996285010544	metal binding site [ion binding]; metal-binding site
996285010545	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
996285010546	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
996285010547	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
996285010548	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
996285010549	dimer interface [polypeptide binding]; other site
996285010550	active site
996285010551	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
996285010552	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
996285010553	DNA binding residues [nucleotide binding]
996285010554	putative dimer interface [polypeptide binding]; other site
996285010555	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
996285010556	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285010557	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
996285010558	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
996285010559	DctM-like transporters; Region: DctM; pfam06808
996285010560	PAS fold; Region: PAS_4; pfam08448
996285010561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285010562	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
996285010563	Walker A motif; other site
996285010564	ATP binding site [chemical binding]; other site
996285010565	Walker B motif; other site
996285010566	arginine finger; other site
996285010567	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285010568	DoxX; Region: DoxX; pfam07681
996285010569	Tannase and feruloyl esterase; Region: Tannase; pfam07519
996285010570	potential frameshift: common BLAST hit: gi|146309370|ref|YP_001189835.1| outer membrane porin
996285010571	outer membrane porin, OprD family; Region: OprD; pfam03573
996285010572	outer membrane porin, OprD family; Region: OprD; pfam03573
996285010573	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
996285010574	EamA-like transporter family; Region: EamA; pfam00892
996285010575	EamA-like transporter family; Region: EamA; pfam00892
996285010576	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
996285010577	active site clefts [active]
996285010578	zinc binding site [ion binding]; other site
996285010579	dimer interface [polypeptide binding]; other site
996285010580	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
996285010581	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
996285010582	active site
996285010583	homotetramer interface [polypeptide binding]; other site
996285010584	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
996285010585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285010586	active site
996285010587	motif I; other site
996285010588	motif II; other site
996285010589	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
996285010590	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285010591	Coenzyme A binding pocket [chemical binding]; other site
996285010592	2-isopropylmalate synthase; Validated; Region: PRK00915
996285010593	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
996285010594	active site
996285010595	catalytic residues [active]
996285010596	metal binding site [ion binding]; metal-binding site
996285010597	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
996285010598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285010599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285010600	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285010601	dimerization interface [polypeptide binding]; other site
996285010602	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
996285010603	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
996285010604	Citrate transporter; Region: CitMHS; pfam03600
996285010605	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
996285010606	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
996285010607	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
996285010608	dimer interface [polypeptide binding]; other site
996285010609	active site
996285010610	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996285010611	catalytic residues [active]
996285010612	substrate binding site [chemical binding]; other site
996285010613	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
996285010614	mce related protein; Region: MCE; pfam02470
996285010615	mce related protein; Region: MCE; pfam02470
996285010616	mce related protein; Region: MCE; pfam02470
996285010617	mce related protein; Region: MCE; pfam02470
996285010618	mce related protein; Region: MCE; pfam02470
996285010619	mce related protein; Region: MCE; pfam02470
996285010620	Paraquat-inducible protein A; Region: PqiA; pfam04403
996285010621	Paraquat-inducible protein A; Region: PqiA; pfam04403
996285010622	TMAO/DMSO reductase; Reviewed; Region: PRK05363
996285010623	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
996285010624	Moco binding site; other site
996285010625	metal coordination site [ion binding]; other site
996285010626	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
996285010627	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
996285010628	ketol-acid reductoisomerase; Provisional; Region: PRK05479
996285010629	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
996285010630	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
996285010631	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
996285010632	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
996285010633	putative valine binding site [chemical binding]; other site
996285010634	dimer interface [polypeptide binding]; other site
996285010635	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
996285010636	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
996285010637	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
996285010638	PYR/PP interface [polypeptide binding]; other site
996285010639	dimer interface [polypeptide binding]; other site
996285010640	TPP binding site [chemical binding]; other site
996285010641	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
996285010642	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
996285010643	TPP-binding site [chemical binding]; other site
996285010644	dimer interface [polypeptide binding]; other site
996285010645	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
996285010646	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
996285010647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
996285010648	TPR motif; other site
996285010649	binding surface
996285010650	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
996285010651	Transglycosylase; Region: Transgly; pfam00912
996285010652	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
996285010653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
996285010654	Predicted kinase [General function prediction only]; Region: COG0645
996285010655	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
996285010656	active site
996285010657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285010658	S-adenosylmethionine binding site [chemical binding]; other site
996285010659	TfoX C-terminal domain; Region: TfoX_C; pfam04994
996285010660	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285010661	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
996285010662	ligand binding site [chemical binding]; other site
996285010663	flexible hinge region; other site
996285010664	Protein of unknown function, DUF399; Region: DUF399; cl01139
996285010665	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
996285010666	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
996285010667	Walker A/P-loop; other site
996285010668	ATP binding site [chemical binding]; other site
996285010669	Q-loop/lid; other site
996285010670	ABC transporter signature motif; other site
996285010671	Walker B; other site
996285010672	D-loop; other site
996285010673	H-loop/switch region; other site
996285010674	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
996285010675	ABC-ATPase subunit  interface; other site
996285010676	dimer interface [polypeptide binding]; other site
996285010677	putative PBP binding regions; other site
996285010678	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
996285010679	iron-sulfur cluster [ion binding]; other site
996285010680	[2Fe-2S] cluster binding site [ion binding]; other site
996285010681	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
996285010682	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
996285010683	Family description; Region: DsbD_2; pfam13386
996285010684	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
996285010685	DsbD alpha interface [polypeptide binding]; other site
996285010686	catalytic residues [active]
996285010687	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
996285010688	Dehydroquinase class II; Region: DHquinase_II; pfam01220
996285010689	active site
996285010690	trimer interface [polypeptide binding]; other site
996285010691	dimer interface [polypeptide binding]; other site
996285010692	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
996285010693	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
996285010694	carboxyltransferase (CT) interaction site; other site
996285010695	biotinylation site [posttranslational modification]; other site
996285010696	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
996285010697	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996285010698	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
996285010699	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
996285010700	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
996285010701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285010702	S-adenosylmethionine binding site [chemical binding]; other site
996285010703	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
996285010704	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
996285010705	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
996285010706	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
996285010707	FMN binding site [chemical binding]; other site
996285010708	active site
996285010709	catalytic residues [active]
996285010710	substrate binding site [chemical binding]; other site
996285010711	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
996285010712	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
996285010713	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
996285010714	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
996285010715	purine monophosphate binding site [chemical binding]; other site
996285010716	dimer interface [polypeptide binding]; other site
996285010717	putative catalytic residues [active]
996285010718	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
996285010719	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
996285010720	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
996285010721	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
996285010722	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
996285010723	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
996285010724	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
996285010725	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
996285010726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285010727	dimer interface [polypeptide binding]; other site
996285010728	phosphorylation site [posttranslational modification]
996285010729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285010730	ATP binding site [chemical binding]; other site
996285010731	Mg2+ binding site [ion binding]; other site
996285010732	G-X-G motif; other site
996285010733	Response regulator receiver domain; Region: Response_reg; pfam00072
996285010734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285010735	active site
996285010736	phosphorylation site [posttranslational modification]
996285010737	intermolecular recognition site; other site
996285010738	dimerization interface [polypeptide binding]; other site
996285010739	Response regulator receiver domain; Region: Response_reg; pfam00072
996285010740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285010741	active site
996285010742	phosphorylation site [posttranslational modification]
996285010743	intermolecular recognition site; other site
996285010744	dimerization interface [polypeptide binding]; other site
996285010745	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
996285010746	Cytochrome P450; Region: p450; cl12078
996285010747	Predicted integral membrane protein [Function unknown]; Region: COG0392
996285010748	Predicted permeases [General function prediction only]; Region: COG0679
996285010749	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
996285010750	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
996285010751	NADP binding site [chemical binding]; other site
996285010752	active site
996285010753	putative substrate binding site [chemical binding]; other site
996285010754	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
996285010755	hypothetical protein; Provisional; Region: PRK08960
996285010756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285010757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285010758	homodimer interface [polypeptide binding]; other site
996285010759	catalytic residue [active]
996285010760	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
996285010761	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
996285010762	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
996285010763	active site
996285010764	nucleotide binding site [chemical binding]; other site
996285010765	HIGH motif; other site
996285010766	KMSKS motif; other site
996285010767	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
996285010768	Na binding site [ion binding]; other site
996285010769	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
996285010770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285010771	dimer interface [polypeptide binding]; other site
996285010772	phosphorylation site [posttranslational modification]
996285010773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285010774	ATP binding site [chemical binding]; other site
996285010775	Mg2+ binding site [ion binding]; other site
996285010776	G-X-G motif; other site
996285010777	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285010778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285010779	active site
996285010780	phosphorylation site [posttranslational modification]
996285010781	intermolecular recognition site; other site
996285010782	dimerization interface [polypeptide binding]; other site
996285010783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285010784	Walker A motif; other site
996285010785	ATP binding site [chemical binding]; other site
996285010786	Walker B motif; other site
996285010787	arginine finger; other site
996285010788	poly(A) polymerase; Region: pcnB; TIGR01942
996285010789	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
996285010790	active site
996285010791	NTP binding site [chemical binding]; other site
996285010792	metal binding triad [ion binding]; metal-binding site
996285010793	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
996285010794	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
996285010795	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
996285010796	catalytic center binding site [active]
996285010797	ATP binding site [chemical binding]; other site
996285010798	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
996285010799	oligomerization interface [polypeptide binding]; other site
996285010800	active site
996285010801	metal binding site [ion binding]; metal-binding site
996285010802	pantoate--beta-alanine ligase; Region: panC; TIGR00018
996285010803	Pantoate-beta-alanine ligase; Region: PanC; cd00560
996285010804	active site
996285010805	ATP-binding site [chemical binding]; other site
996285010806	pantoate-binding site; other site
996285010807	HXXH motif; other site
996285010808	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
996285010809	tetramerization interface [polypeptide binding]; other site
996285010810	active site
996285010811	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
996285010812	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
996285010813	active site
996285010814	dimer interface [polypeptide binding]; other site
996285010815	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
996285010816	dimer interface [polypeptide binding]; other site
996285010817	active site
996285010818	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
996285010819	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
996285010820	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
996285010821	putative RNA binding site [nucleotide binding]; other site
996285010822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285010823	S-adenosylmethionine binding site [chemical binding]; other site
996285010824	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
996285010825	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
996285010826	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
996285010827	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
996285010828	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
996285010829	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
996285010830	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
996285010831	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
996285010832	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
996285010833	RNase E interface [polypeptide binding]; other site
996285010834	trimer interface [polypeptide binding]; other site
996285010835	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
996285010836	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
996285010837	RNase E interface [polypeptide binding]; other site
996285010838	trimer interface [polypeptide binding]; other site
996285010839	active site
996285010840	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
996285010841	putative nucleic acid binding region [nucleotide binding]; other site
996285010842	G-X-X-G motif; other site
996285010843	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
996285010844	RNA binding site [nucleotide binding]; other site
996285010845	domain interface; other site
996285010846	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
996285010847	16S/18S rRNA binding site [nucleotide binding]; other site
996285010848	S13e-L30e interaction site [polypeptide binding]; other site
996285010849	25S rRNA binding site [nucleotide binding]; other site
996285010850	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
996285010851	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
996285010852	RNA binding site [nucleotide binding]; other site
996285010853	active site
996285010854	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
996285010855	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
996285010856	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
996285010857	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
996285010858	translation initiation factor IF-2; Region: IF-2; TIGR00487
996285010859	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
996285010860	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
996285010861	G1 box; other site
996285010862	putative GEF interaction site [polypeptide binding]; other site
996285010863	GTP/Mg2+ binding site [chemical binding]; other site
996285010864	Switch I region; other site
996285010865	G2 box; other site
996285010866	G3 box; other site
996285010867	Switch II region; other site
996285010868	G4 box; other site
996285010869	G5 box; other site
996285010870	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
996285010871	Translation-initiation factor 2; Region: IF-2; pfam11987
996285010872	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
996285010873	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
996285010874	NusA N-terminal domain; Region: NusA_N; pfam08529
996285010875	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
996285010876	RNA binding site [nucleotide binding]; other site
996285010877	homodimer interface [polypeptide binding]; other site
996285010878	NusA-like KH domain; Region: KH_5; pfam13184
996285010879	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
996285010880	G-X-X-G motif; other site
996285010881	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
996285010882	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
996285010883	ribosome maturation protein RimP; Reviewed; Region: PRK00092
996285010884	Sm and related proteins; Region: Sm_like; cl00259
996285010885	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
996285010886	putative oligomer interface [polypeptide binding]; other site
996285010887	putative RNA binding site [nucleotide binding]; other site
996285010888	Preprotein translocase SecG subunit; Region: SecG; pfam03840
996285010889	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
996285010890	substrate binding site [chemical binding]; other site
996285010891	catalytic triad [active]
996285010892	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
996285010893	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
996285010894	active site
996285010895	substrate binding site [chemical binding]; other site
996285010896	metal binding site [ion binding]; metal-binding site
996285010897	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
996285010898	dihydropteroate synthase; Region: DHPS; TIGR01496
996285010899	substrate binding pocket [chemical binding]; other site
996285010900	dimer interface [polypeptide binding]; other site
996285010901	inhibitor binding site; inhibition site
996285010902	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
996285010903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285010904	Walker A motif; other site
996285010905	ATP binding site [chemical binding]; other site
996285010906	Walker B motif; other site
996285010907	arginine finger; other site
996285010908	Peptidase family M41; Region: Peptidase_M41; pfam01434
996285010909	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
996285010910	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
996285010911	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
996285010912	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
996285010913	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
996285010914	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996285010915	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
996285010916	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
996285010917	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
996285010918	ATP-grasp domain; Region: ATP-grasp_4; cl17255
996285010919	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
996285010920	IMP binding site; other site
996285010921	dimer interface [polypeptide binding]; other site
996285010922	interdomain contacts; other site
996285010923	partial ornithine binding site; other site
996285010924	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
996285010925	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
996285010926	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
996285010927	catalytic site [active]
996285010928	subunit interface [polypeptide binding]; other site
996285010929	dihydrodipicolinate reductase; Region: dapB; TIGR00036
996285010930	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
996285010931	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
996285010932	chaperone protein DnaJ; Provisional; Region: PRK10767
996285010933	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
996285010934	HSP70 interaction site [polypeptide binding]; other site
996285010935	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
996285010936	substrate binding site [polypeptide binding]; other site
996285010937	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
996285010938	Zn binding sites [ion binding]; other site
996285010939	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
996285010940	dimer interface [polypeptide binding]; other site
996285010941	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
996285010942	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
996285010943	nucleotide binding site [chemical binding]; other site
996285010944	NEF interaction site [polypeptide binding]; other site
996285010945	SBD interface [polypeptide binding]; other site
996285010946	GrpE; Region: GrpE; pfam01025
996285010947	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
996285010948	dimer interface [polypeptide binding]; other site
996285010949	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
996285010950	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
996285010951	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
996285010952	Walker A/P-loop; other site
996285010953	ATP binding site [chemical binding]; other site
996285010954	Q-loop/lid; other site
996285010955	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
996285010956	ABC transporter signature motif; other site
996285010957	Walker B; other site
996285010958	D-loop; other site
996285010959	H-loop/switch region; other site
996285010960	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
996285010961	metal binding site 2 [ion binding]; metal-binding site
996285010962	putative DNA binding helix; other site
996285010963	metal binding site 1 [ion binding]; metal-binding site
996285010964	dimer interface [polypeptide binding]; other site
996285010965	structural Zn2+ binding site [ion binding]; other site
996285010966	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
996285010967	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
996285010968	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
996285010969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
996285010970	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
996285010971	putative coenzyme Q binding site [chemical binding]; other site
996285010972	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
996285010973	SmpB-tmRNA interface; other site
996285010974	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
996285010975	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285010976	DNA-binding site [nucleotide binding]; DNA binding site
996285010977	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
996285010978	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
996285010979	L-lactate permease; Region: Lactate_perm; cl00701
996285010980	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
996285010981	Cysteine-rich domain; Region: CCG; pfam02754
996285010982	Cysteine-rich domain; Region: CCG; pfam02754
996285010983	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
996285010984	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
996285010985	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285010986	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
996285010987	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
996285010988	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
996285010989	FAD binding domain; Region: FAD_binding_4; pfam01565
996285010990	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
996285010991	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
996285010992	Cysteine-rich domain; Region: CCG; pfam02754
996285010993	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
996285010994	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285010995	active site
996285010996	DNA binding site [nucleotide binding]
996285010997	Int/Topo IB signature motif; other site
996285010998	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
996285010999	active site
996285011000	DNA binding site [nucleotide binding]
996285011001	Int/Topo IB signature motif; other site
996285011002	putative transposase OrfB; Reviewed; Region: PHA02517
996285011003	HTH-like domain; Region: HTH_21; pfam13276
996285011004	Integrase core domain; Region: rve; pfam00665
996285011005	Integrase core domain; Region: rve_2; pfam13333
996285011006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
996285011007	Transposase; Region: HTH_Tnp_1; pfam01527
996285011008	Transposase; Region: HTH_Tnp_1; cl17663
996285011009	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
996285011010	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
996285011011	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285011012	Outer membrane efflux protein; Region: OEP; pfam02321
996285011013	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
996285011014	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
996285011015	FAD binding pocket [chemical binding]; other site
996285011016	FAD binding motif [chemical binding]; other site
996285011017	phosphate binding motif [ion binding]; other site
996285011018	beta-alpha-beta structure motif; other site
996285011019	NAD binding pocket [chemical binding]; other site
996285011020	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
996285011021	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
996285011022	catalytic loop [active]
996285011023	iron binding site [ion binding]; other site
996285011024	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285011025	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
996285011026	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
996285011027	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
996285011028	Multicopper oxidase; Region: Cu-oxidase; pfam00394
996285011029	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
996285011030	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
996285011031	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
996285011032	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
996285011033	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
996285011034	Predicted metal-binding protein [General function prediction only]; Region: COG3019
996285011035	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285011036	metal-binding site [ion binding]
996285011037	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
996285011038	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285011039	Soluble P-type ATPase [General function prediction only]; Region: COG4087
996285011040	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
996285011041	DNA binding site [nucleotide binding]
996285011042	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
996285011043	HAMP domain; Region: HAMP; pfam00672
996285011044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285011045	dimer interface [polypeptide binding]; other site
996285011046	phosphorylation site [posttranslational modification]
996285011047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011048	ATP binding site [chemical binding]; other site
996285011049	Mg2+ binding site [ion binding]; other site
996285011050	G-X-G motif; other site
996285011051	potential frameshift: common BLAST hit: gi|163858497|ref|YP_001632795.1| ISPssy, transposase
996285011052	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
996285011053	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285011054	Transposase domain (DUF772); Region: DUF772; pfam05598
996285011055	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285011056	putative transposase OrfB; Reviewed; Region: PHA02517
996285011057	HTH-like domain; Region: HTH_21; pfam13276
996285011058	Integrase core domain; Region: rve; pfam00665
996285011059	Integrase core domain; Region: rve_2; pfam13333
996285011060	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
996285011061	Transposase; Region: HTH_Tnp_1; pfam01527
996285011062	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
996285011063	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
996285011064	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
996285011065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285011066	dimerization interface [polypeptide binding]; other site
996285011067	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285011068	dimer interface [polypeptide binding]; other site
996285011069	phosphorylation site [posttranslational modification]
996285011070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011071	ATP binding site [chemical binding]; other site
996285011072	Mg2+ binding site [ion binding]; other site
996285011073	G-X-G motif; other site
996285011074	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
996285011075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285011076	active site
996285011077	phosphorylation site [posttranslational modification]
996285011078	intermolecular recognition site; other site
996285011079	dimerization interface [polypeptide binding]; other site
996285011080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285011081	DNA binding site [nucleotide binding]
996285011082	outer membrane porin, OprD family; Region: OprD; pfam03573
996285011083	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
996285011084	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285011085	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
996285011086	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285011087	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
996285011088	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
996285011089	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
996285011090	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
996285011091	DNA binding residues [nucleotide binding]
996285011092	dimer interface [polypeptide binding]; other site
996285011093	mercury binding site [ion binding]; other site
996285011094	MerT mercuric transport protein; Region: MerT; cl03578
996285011095	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285011096	metal-binding site [ion binding]
996285011097	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
996285011098	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
996285011099	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
996285011100	Transposase domain (DUF772); Region: DUF772; pfam05598
996285011101	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285011102	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285011103	WYL domain; Region: WYL; pfam13280
996285011104	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
996285011105	AAA domain; Region: AAA_30; pfam13604
996285011106	Family description; Region: UvrD_C_2; pfam13538
996285011107	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
996285011108	Family description; Region: UvrD_C_2; pfam13538
996285011109	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
996285011110	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
996285011111	Transposase; Region: HTH_Tnp_1; pfam01527
996285011112	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
996285011113	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
996285011114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285011115	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
996285011116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
996285011117	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
996285011118	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
996285011119	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
996285011120	WYL domain; Region: WYL; pfam13280
996285011121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
996285011122	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
996285011123	putative transposase OrfB; Reviewed; Region: PHA02517
996285011124	HTH-like domain; Region: HTH_21; pfam13276
996285011125	Integrase core domain; Region: rve; pfam00665
996285011126	Integrase core domain; Region: rve_3; pfam13683
996285011127	DEAD-like helicases superfamily; Region: DEXDc; smart00487
996285011128	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285011129	ATP binding site [chemical binding]; other site
996285011130	putative Mg++ binding site [ion binding]; other site
996285011131	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285011132	nucleotide binding region [chemical binding]; other site
996285011133	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
996285011134	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
996285011135	tellurite resistance protein terB; Region: terB; cd07176
996285011136	putative metal binding site [ion binding]; other site
996285011137	Transposase domain (DUF772); Region: DUF772; pfam05598
996285011138	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285011139	Protein of unknown function (DUF 659); Region: DUF659; pfam04937
996285011140	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285011141	putative transposase OrfB; Reviewed; Region: PHA02517
996285011142	HTH-like domain; Region: HTH_21; pfam13276
996285011143	Integrase core domain; Region: rve; pfam00665
996285011144	Integrase core domain; Region: rve_2; pfam13333
996285011145	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
996285011146	nudix motif; other site
996285011147	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285011148	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285011149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285011150	dimer interface [polypeptide binding]; other site
996285011151	phosphorylation site [posttranslational modification]
996285011152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011153	ATP binding site [chemical binding]; other site
996285011154	Mg2+ binding site [ion binding]; other site
996285011155	G-X-G motif; other site
996285011156	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285011157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285011158	active site
996285011159	phosphorylation site [posttranslational modification]
996285011160	intermolecular recognition site; other site
996285011161	dimerization interface [polypeptide binding]; other site
996285011162	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
996285011163	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
996285011164	Walker A/P-loop; other site
996285011165	ATP binding site [chemical binding]; other site
996285011166	Q-loop/lid; other site
996285011167	ABC transporter signature motif; other site
996285011168	Walker B; other site
996285011169	D-loop; other site
996285011170	H-loop/switch region; other site
996285011171	TOBE domain; Region: TOBE_2; pfam08402
996285011172	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
996285011173	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
996285011174	active site
996285011175	catalytic site [active]
996285011176	maltose O-acetyltransferase; Provisional; Region: PRK10092
996285011177	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
996285011178	active site
996285011179	substrate binding site [chemical binding]; other site
996285011180	trimer interface [polypeptide binding]; other site
996285011181	CoA binding site [chemical binding]; other site
996285011182	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
996285011183	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
996285011184	C-terminal domain interface [polypeptide binding]; other site
996285011185	GSH binding site (G-site) [chemical binding]; other site
996285011186	dimer interface [polypeptide binding]; other site
996285011187	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
996285011188	N-terminal domain interface [polypeptide binding]; other site
996285011189	dimer interface [polypeptide binding]; other site
996285011190	substrate binding pocket (H-site) [chemical binding]; other site
996285011191	transcriptional regulator MalT; Provisional; Region: PRK04841
996285011192	AAA ATPase domain; Region: AAA_16; pfam13191
996285011193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
996285011194	DNA binding residues [nucleotide binding]
996285011195	dimerization interface [polypeptide binding]; other site
996285011196	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
996285011197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285011198	dimer interface [polypeptide binding]; other site
996285011199	conserved gate region; other site
996285011200	putative PBP binding loops; other site
996285011201	ABC-ATPase subunit interface; other site
996285011202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285011203	dimer interface [polypeptide binding]; other site
996285011204	conserved gate region; other site
996285011205	putative PBP binding loops; other site
996285011206	ABC-ATPase subunit interface; other site
996285011207	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
996285011208	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
996285011209	alpha-amylase; Reviewed; Region: malS; PRK09505
996285011210	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
996285011211	active site
996285011212	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
996285011213	active site
996285011214	catalytic site [active]
996285011215	catalytic site [active]
996285011216	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
996285011217	active site
996285011218	substrate binding site [chemical binding]; other site
996285011219	ATP binding site [chemical binding]; other site
996285011220	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
996285011221	active site
996285011222	Ca binding site [ion binding]; other site
996285011223	catalytic site [active]
996285011224	Domain of unknown function (DUF1921); Region: DUF1921; pfam09081
996285011225	Glucan 1,4-alpha-maltotetraohydrolase (alpha-MTH), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from...; Region: CBM20_alpha_MTH; cd05810
996285011226	starch-binding site 2 [chemical binding]; other site
996285011227	starch-binding site 1 [chemical binding]; other site
996285011228	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
996285011229	trimer interface; other site
996285011230	sugar binding site [chemical binding]; other site
996285011231	Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148
996285011232	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
996285011233	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996285011234	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996285011235	active site
996285011236	catalytic tetrad [active]
996285011237	betaine aldehyde dehydrogenase; Region: PLN02467
996285011238	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
996285011239	tetrameric interface [polypeptide binding]; other site
996285011240	activator binding site; other site
996285011241	NADP binding site [chemical binding]; other site
996285011242	substrate binding site [chemical binding]; other site
996285011243	catalytic residues [active]
996285011244	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
996285011245	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
996285011246	active site
996285011247	intersubunit interface [polypeptide binding]; other site
996285011248	catalytic residue [active]
996285011249	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
996285011250	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
996285011251	putative active site [active]
996285011252	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
996285011253	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
996285011254	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
996285011255	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
996285011256	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
996285011257	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
996285011258	putative active site [active]
996285011259	glucokinase; Provisional; Region: glk; PRK00292
996285011260	glucokinase, proteobacterial type; Region: glk; TIGR00749
996285011261	phosphogluconate dehydratase; Validated; Region: PRK09054
996285011262	6-phosphogluconate dehydratase; Region: edd; TIGR01196
996285011263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285011264	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285011265	putative substrate translocation pore; other site
996285011266	Fe2+ transport protein; Region: Iron_transport; pfam10634
996285011267	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
996285011268	Iron permease FTR1 family; Region: FTR1; cl00475
996285011269	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
996285011270	4Fe-4S binding domain; Region: Fer4_5; pfam12801
996285011271	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
996285011272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285011273	FeS/SAM binding site; other site
996285011274	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
996285011275	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
996285011276	ATP cone domain; Region: ATP-cone; pfam03477
996285011277	Class III ribonucleotide reductase; Region: RNR_III; cd01675
996285011278	effector binding site; other site
996285011279	active site
996285011280	Zn binding site [ion binding]; other site
996285011281	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
996285011282	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285011283	ligand binding site [chemical binding]; other site
996285011284	flexible hinge region; other site
996285011285	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
996285011286	putative switch regulator; other site
996285011287	non-specific DNA interactions [nucleotide binding]; other site
996285011288	DNA binding site [nucleotide binding]
996285011289	sequence specific DNA binding site [nucleotide binding]; other site
996285011290	putative cAMP binding site [chemical binding]; other site
996285011291	DGC domain; Region: DGC; pfam08859
996285011292	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
996285011293	putative protease; Provisional; Region: PRK15447
996285011294	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
996285011295	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
996285011296	Peptidase family U32; Region: Peptidase_U32; pfam01136
996285011297	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
996285011298	GAF domain; Region: GAF; pfam01590
996285011299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011300	Walker A motif; other site
996285011301	ATP binding site [chemical binding]; other site
996285011302	Walker B motif; other site
996285011303	arginine finger; other site
996285011304	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
996285011305	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
996285011306	Hemerythrin-like domain; Region: Hr-like; cd12108
996285011307	Fe binding site [ion binding]; other site
996285011308	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
996285011309	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285011310	ligand binding site [chemical binding]; other site
996285011311	flexible hinge region; other site
996285011312	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
996285011313	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
996285011314	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
996285011315	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
996285011316	metal ion-dependent adhesion site (MIDAS); other site
996285011317	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
996285011318	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
996285011319	Low-spin heme binding site [chemical binding]; other site
996285011320	D-pathway; other site
996285011321	K-pathway; other site
996285011322	Binuclear center (active site) [active]
996285011323	Putative proton exit pathway; other site
996285011324	Putative water exit pathway; other site
996285011325	Cytochrome c; Region: Cytochrom_C; pfam00034
996285011326	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285011327	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285011328	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285011329	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285011330	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
996285011331	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
996285011332	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285011333	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285011334	Cytochrome c; Region: Cytochrom_C; cl11414
996285011335	Ethylbenzene dehydrogenase; Region: EB_dh; smart00887
996285011336	putative ligand binding site [chemical binding]; other site
996285011337	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
996285011338	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
996285011339	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285011340	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285011341	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
996285011342	MoxR-like ATPases [General function prediction only]; Region: COG0714
996285011343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011344	Walker A motif; other site
996285011345	ATP binding site [chemical binding]; other site
996285011346	Walker B motif; other site
996285011347	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
996285011348	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
996285011349	Subunit I/III interface [polypeptide binding]; other site
996285011350	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
996285011351	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285011352	FeS/SAM binding site; other site
996285011353	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
996285011354	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
996285011355	active site
996285011356	SAM binding site [chemical binding]; other site
996285011357	homodimer interface [polypeptide binding]; other site
996285011358	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285011359	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285011360	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
996285011361	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
996285011362	structural tetrad; other site
996285011363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285011364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285011365	LysR substrate binding domain; Region: LysR_substrate; pfam03466
996285011366	dimerization interface [polypeptide binding]; other site
996285011367	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
996285011368	HPP family; Region: HPP; pfam04982
996285011369	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
996285011370	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
996285011371	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
996285011372	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285011373	dimer interface [polypeptide binding]; other site
996285011374	putative CheW interface [polypeptide binding]; other site
996285011375	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
996285011376	short chain dehydrogenase; Provisional; Region: PRK06500
996285011377	classical (c) SDRs; Region: SDR_c; cd05233
996285011378	NAD(P) binding site [chemical binding]; other site
996285011379	active site
996285011380	NnrS protein; Region: NnrS; pfam05940
996285011381	twin arginine translocase protein A; Provisional; Region: tatA; PRK04598
996285011382	NosL; Region: NosL; pfam05573
996285011383	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
996285011384	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
996285011385	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996285011386	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996285011387	Walker A/P-loop; other site
996285011388	ATP binding site [chemical binding]; other site
996285011389	Q-loop/lid; other site
996285011390	ABC transporter signature motif; other site
996285011391	Walker B; other site
996285011392	D-loop; other site
996285011393	H-loop/switch region; other site
996285011394	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
996285011395	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
996285011396	nitrous-oxide reductase; Validated; Region: PRK02888
996285011397	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
996285011398	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
996285011399	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
996285011400	4Fe-4S binding domain; Region: Fer4_5; pfam12801
996285011401	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
996285011402	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285011403	active site
996285011404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399
996285011405	Protein of unknown function, DUF488; Region: DUF488; cl01246
996285011406	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285011407	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285011408	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285011409	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285011410	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
996285011411	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285011412	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
996285011413	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
996285011414	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
996285011415	CheB methylesterase; Region: CheB_methylest; pfam01339
996285011416	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
996285011417	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
996285011418	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
996285011419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285011420	PAS domain; Region: PAS_9; pfam13426
996285011421	putative active site [active]
996285011422	heme pocket [chemical binding]; other site
996285011423	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
996285011424	PAS domain; Region: PAS_10; pfam13596
996285011425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285011426	putative active site [active]
996285011427	heme pocket [chemical binding]; other site
996285011428	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996285011429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285011430	putative active site [active]
996285011431	heme pocket [chemical binding]; other site
996285011432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285011433	dimer interface [polypeptide binding]; other site
996285011434	phosphorylation site [posttranslational modification]
996285011435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011436	ATP binding site [chemical binding]; other site
996285011437	Mg2+ binding site [ion binding]; other site
996285011438	G-X-G motif; other site
996285011439	Response regulator receiver domain; Region: Response_reg; pfam00072
996285011440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285011441	active site
996285011442	phosphorylation site [posttranslational modification]
996285011443	intermolecular recognition site; other site
996285011444	dimerization interface [polypeptide binding]; other site
996285011445	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
996285011446	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
996285011447	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285011448	putative active site [active]
996285011449	heme pocket [chemical binding]; other site
996285011450	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011451	Walker A motif; other site
996285011452	ATP binding site [chemical binding]; other site
996285011453	Walker B motif; other site
996285011454	arginine finger; other site
996285011455	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
996285011456	cofactor binding site; other site
996285011457	metal binding site [ion binding]; metal-binding site
996285011458	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
996285011459	aromatic arch; other site
996285011460	DCoH dimer interaction site [polypeptide binding]; other site
996285011461	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
996285011462	DCoH tetramer interaction site [polypeptide binding]; other site
996285011463	substrate binding site [chemical binding]; other site
996285011464	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
996285011465	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285011466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285011467	homodimer interface [polypeptide binding]; other site
996285011468	catalytic residue [active]
996285011469	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
996285011470	cyanate hydratase; Validated; Region: PRK02866
996285011471	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
996285011472	oligomer interface [polypeptide binding]; other site
996285011473	active site
996285011474	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
996285011475	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
996285011476	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
996285011477	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
996285011478	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
996285011479	tetramer interface [polypeptide binding]; other site
996285011480	heme binding pocket [chemical binding]; other site
996285011481	cytosine permease; Provisional; Region: codB; PRK11017
996285011482	Na binding site [ion binding]; other site
996285011483	cytosine deaminase; Provisional; Region: PRK09230
996285011484	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
996285011485	active site
996285011486	Cytochrome c553 [Energy production and conversion]; Region: COG2863
996285011487	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285011488	Cytochrome c; Region: Cytochrom_C; cl11414
996285011489	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
996285011490	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
996285011491	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
996285011492	PhnA protein; Region: PhnA; pfam03831
996285011493	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
996285011494	DNA-binding site [nucleotide binding]; DNA binding site
996285011495	RNA-binding motif; other site
996285011496	Predicted membrane protein [Function unknown]; Region: COG3326
996285011497	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
996285011498	putative metal binding site [ion binding]; other site
996285011499	Uncharacterized conserved protein [Function unknown]; Region: COG1432
996285011500	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
996285011501	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285011502	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285011503	substrate binding pocket [chemical binding]; other site
996285011504	membrane-bound complex binding site; other site
996285011505	hinge residues; other site
996285011506	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285011507	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285011508	metal binding site [ion binding]; metal-binding site
996285011509	active site
996285011510	I-site; other site
996285011511	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285011512	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
996285011513	TM-ABC transporter signature motif; other site
996285011514	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285011515	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
996285011516	TM-ABC transporter signature motif; other site
996285011517	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
996285011518	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
996285011519	Walker A/P-loop; other site
996285011520	ATP binding site [chemical binding]; other site
996285011521	Q-loop/lid; other site
996285011522	ABC transporter signature motif; other site
996285011523	Walker B; other site
996285011524	D-loop; other site
996285011525	H-loop/switch region; other site
996285011526	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
996285011527	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
996285011528	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
996285011529	putative ligand binding site [chemical binding]; other site
996285011530	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285011531	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
996285011532	active site
996285011533	metal binding site [ion binding]; metal-binding site
996285011534	oxidase reductase; Provisional; Region: PTZ00273
996285011535	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
996285011536	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
996285011537	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
996285011538	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
996285011539	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
996285011540	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
996285011541	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285011542	putative metal binding site [ion binding]; other site
996285011543	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
996285011544	Uncharacterized conserved protein [Function unknown]; Region: COG2128
996285011545	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
996285011546	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285011547	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
996285011548	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
996285011549	conserved cys residue [active]
996285011550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285011551	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285011552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285011553	Major Facilitator Superfamily; Region: MFS_1; pfam07690
996285011554	putative substrate translocation pore; other site
996285011555	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
996285011556	active site
996285011557	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
996285011558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285011559	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
996285011560	pyrimidine utilization protein A; Region: RutA; TIGR03612
996285011561	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
996285011562	active site
996285011563	dimer interface [polypeptide binding]; other site
996285011564	non-prolyl cis peptide bond; other site
996285011565	insertion regions; other site
996285011566	Isochorismatase family; Region: Isochorismatase; pfam00857
996285011567	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
996285011568	catalytic triad [active]
996285011569	conserved cis-peptide bond; other site
996285011570	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
996285011571	homotrimer interaction site [polypeptide binding]; other site
996285011572	putative active site [active]
996285011573	pyrimidine utilization protein D; Region: RutD; TIGR03611
996285011574	Serine hydrolase (FSH1); Region: FSH1; pfam03959
996285011575	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
996285011576	putative FMN binding site [chemical binding]; other site
996285011577	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
996285011578	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
996285011579	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
996285011580	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
996285011581	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
996285011582	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
996285011583	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
996285011584	dimerization interface [polypeptide binding]; other site
996285011585	Uncharacterized conserved protein [Function unknown]; Region: COG1739
996285011586	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
996285011587	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
996285011588	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
996285011589	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
996285011590	active site
996285011591	purine riboside binding site [chemical binding]; other site
996285011592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285011593	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
996285011594	putative substrate translocation pore; other site
996285011595	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
996285011596	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285011597	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
996285011598	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285011599	metal-binding site [ion binding]
996285011600	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
996285011601	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285011602	metal-binding site [ion binding]
996285011603	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
996285011604	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285011605	metal-binding site [ion binding]
996285011606	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285011607	Soluble P-type ATPase [General function prediction only]; Region: COG4087
996285011608	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
996285011609	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
996285011610	DNA binding residues [nucleotide binding]
996285011611	dimer interface [polypeptide binding]; other site
996285011612	copper binding site [ion binding]; other site
996285011613	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
996285011614	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
996285011615	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285011616	dimerization interface [polypeptide binding]; other site
996285011617	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285011618	dimer interface [polypeptide binding]; other site
996285011619	putative CheW interface [polypeptide binding]; other site
996285011620	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
996285011621	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
996285011622	heme binding site [chemical binding]; other site
996285011623	ferroxidase pore; other site
996285011624	ferroxidase diiron center [ion binding]; other site
996285011625	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
996285011626	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285011627	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285011628	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
996285011629	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
996285011630	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
996285011631	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
996285011632	ATP binding site [chemical binding]; other site
996285011633	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
996285011634	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
996285011635	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285011636	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
996285011637	DNA binding site [nucleotide binding]
996285011638	active site
996285011639	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
996285011640	active site
996285011641	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285011642	dimerization interface [polypeptide binding]; other site
996285011643	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285011644	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285011645	dimer interface [polypeptide binding]; other site
996285011646	putative CheW interface [polypeptide binding]; other site
996285011647	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
996285011648	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
996285011649	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
996285011650	amidase catalytic site [active]
996285011651	Zn binding residues [ion binding]; other site
996285011652	substrate binding site [chemical binding]; other site
996285011653	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
996285011654	Active_site [active]
996285011655	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
996285011656	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
996285011657	conserved cys residue [active]
996285011658	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285011659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285011660	Predicted ATPase [General function prediction only]; Region: COG1485
996285011661	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
996285011662	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
996285011663	active site
996285011664	HIGH motif; other site
996285011665	dimer interface [polypeptide binding]; other site
996285011666	KMSKS motif; other site
996285011667	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
996285011668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
996285011669	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
996285011670	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
996285011671	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
996285011672	dimerization interface [polypeptide binding]; other site
996285011673	active site
996285011674	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
996285011675	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
996285011676	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
996285011677	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
996285011678	Clp amino terminal domain; Region: Clp_N; pfam02861
996285011679	Clp amino terminal domain; Region: Clp_N; pfam02861
996285011680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011681	Walker A motif; other site
996285011682	ATP binding site [chemical binding]; other site
996285011683	Walker B motif; other site
996285011684	arginine finger; other site
996285011685	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011686	Walker A motif; other site
996285011687	ATP binding site [chemical binding]; other site
996285011688	Walker B motif; other site
996285011689	arginine finger; other site
996285011690	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
996285011691	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
996285011692	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
996285011693	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
996285011694	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
996285011695	RNA binding surface [nucleotide binding]; other site
996285011696	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
996285011697	active site
996285011698	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
996285011699	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285011700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285011701	dimer interface [polypeptide binding]; other site
996285011702	phosphorylation site [posttranslational modification]
996285011703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011704	ATP binding site [chemical binding]; other site
996285011705	Mg2+ binding site [ion binding]; other site
996285011706	G-X-G motif; other site
996285011707	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285011708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285011709	active site
996285011710	phosphorylation site [posttranslational modification]
996285011711	intermolecular recognition site; other site
996285011712	dimerization interface [polypeptide binding]; other site
996285011713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011714	Walker A motif; other site
996285011715	ATP binding site [chemical binding]; other site
996285011716	Walker B motif; other site
996285011717	arginine finger; other site
996285011718	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285011719	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
996285011720	Response regulator receiver domain; Region: Response_reg; pfam00072
996285011721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285011722	active site
996285011723	phosphorylation site [posttranslational modification]
996285011724	intermolecular recognition site; other site
996285011725	dimerization interface [polypeptide binding]; other site
996285011726	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285011727	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285011728	metal binding site [ion binding]; metal-binding site
996285011729	active site
996285011730	I-site; other site
996285011731	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
996285011732	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285011733	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285011734	dimer interface [polypeptide binding]; other site
996285011735	putative CheW interface [polypeptide binding]; other site
996285011736	hypothetical protein; Provisional; Region: PRK01254
996285011737	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
996285011738	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
996285011739	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
996285011740	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
996285011741	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
996285011742	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285011743	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285011744	metal binding site [ion binding]; metal-binding site
996285011745	active site
996285011746	I-site; other site
996285011747	alanine racemase; Reviewed; Region: alr; PRK00053
996285011748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
996285011749	active site
996285011750	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996285011751	substrate binding site [chemical binding]; other site
996285011752	catalytic residues [active]
996285011753	dimer interface [polypeptide binding]; other site
996285011754	replicative DNA helicase; Provisional; Region: PRK05748
996285011755	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
996285011756	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
996285011757	Walker A motif; other site
996285011758	ATP binding site [chemical binding]; other site
996285011759	Walker B motif; other site
996285011760	DNA binding loops [nucleotide binding]
996285011761	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
996285011762	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
996285011763	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
996285011764	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
996285011765	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
996285011766	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
996285011767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285011768	putative active site [active]
996285011769	heme pocket [chemical binding]; other site
996285011770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285011771	dimer interface [polypeptide binding]; other site
996285011772	phosphorylation site [posttranslational modification]
996285011773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011774	ATP binding site [chemical binding]; other site
996285011775	Mg2+ binding site [ion binding]; other site
996285011776	G-X-G motif; other site
996285011777	Response regulator receiver domain; Region: Response_reg; pfam00072
996285011778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285011779	active site
996285011780	phosphorylation site [posttranslational modification]
996285011781	intermolecular recognition site; other site
996285011782	dimerization interface [polypeptide binding]; other site
996285011783	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
996285011784	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
996285011785	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
996285011786	ribonuclease R; Region: RNase_R; TIGR02063
996285011787	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
996285011788	RNB domain; Region: RNB; pfam00773
996285011789	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
996285011790	RNA binding site [nucleotide binding]; other site
996285011791	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
996285011792	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
996285011793	GDP-binding site [chemical binding]; other site
996285011794	ACT binding site; other site
996285011795	IMP binding site; other site
996285011796	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
996285011797	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
996285011798	dimer interface [polypeptide binding]; other site
996285011799	motif 1; other site
996285011800	active site
996285011801	motif 2; other site
996285011802	motif 3; other site
996285011803	FtsH protease regulator HflC; Provisional; Region: PRK11029
996285011804	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
996285011805	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
996285011806	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
996285011807	HflK protein; Region: hflK; TIGR01933
996285011808	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
996285011809	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
996285011810	HflX GTPase family; Region: HflX; cd01878
996285011811	G1 box; other site
996285011812	GTP/Mg2+ binding site [chemical binding]; other site
996285011813	Switch I region; other site
996285011814	G2 box; other site
996285011815	G3 box; other site
996285011816	Switch II region; other site
996285011817	G4 box; other site
996285011818	G5 box; other site
996285011819	bacterial Hfq-like; Region: Hfq; cd01716
996285011820	hexamer interface [polypeptide binding]; other site
996285011821	Sm1 motif; other site
996285011822	RNA binding site [nucleotide binding]; other site
996285011823	Sm2 motif; other site
996285011824	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
996285011825	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
996285011826	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
996285011827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285011828	ATP binding site [chemical binding]; other site
996285011829	Mg2+ binding site [ion binding]; other site
996285011830	G-X-G motif; other site
996285011831	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
996285011832	ATP binding site [chemical binding]; other site
996285011833	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
996285011834	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
996285011835	AMIN domain; Region: AMIN; pfam11741
996285011836	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
996285011837	active site
996285011838	metal binding site [ion binding]; metal-binding site
996285011839	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
996285011840	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
996285011841	putative carbohydrate kinase; Provisional; Region: PRK10565
996285011842	Uncharacterized conserved protein [Function unknown]; Region: COG0062
996285011843	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
996285011844	epoxyqueuosine reductase; Region: TIGR00276
996285011845	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
996285011846	FtsH Extracellular; Region: FtsH_ext; pfam06480
996285011847	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
996285011848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285011849	Walker A motif; other site
996285011850	ATP binding site [chemical binding]; other site
996285011851	Walker B motif; other site
996285011852	arginine finger; other site
996285011853	Peptidase family M41; Region: Peptidase_M41; pfam01434
996285011854	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
996285011855	aromatic acid decarboxylase; Validated; Region: PRK05920
996285011856	Flavoprotein; Region: Flavoprotein; pfam02441
996285011857	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
996285011858	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
996285011859	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
996285011860	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
996285011861	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
996285011862	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996285011863	NAD(P) binding site [chemical binding]; other site
996285011864	catalytic residues [active]
996285011865	ethanolamine permease; Region: 2A0305; TIGR00908
996285011866	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
996285011867	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
996285011868	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
996285011869	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
996285011870	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
996285011871	putative active site [active]
996285011872	putative metal binding site [ion binding]; other site
996285011873	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
996285011874	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
996285011875	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
996285011876	homotrimer interaction site [polypeptide binding]; other site
996285011877	putative active site [active]
996285011878	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
996285011879	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
996285011880	dimer interface [polypeptide binding]; other site
996285011881	substrate binding site [chemical binding]; other site
996285011882	metal binding sites [ion binding]; metal-binding site
996285011883	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285011884	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285011885	metal binding site [ion binding]; metal-binding site
996285011886	active site
996285011887	I-site; other site
996285011888	PAS fold; Region: PAS_4; pfam08448
996285011889	potential frameshift: common BLAST hit: gi|339495730|ref|YP_004716023.1| nitrate/sulfonate/bicarbonate ABC transporter periplasmic protein
996285011890	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285011891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
996285011892	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285011893	dimerization interface [polypeptide binding]; other site
996285011894	PAS domain S-box; Region: sensory_box; TIGR00229
996285011895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285011896	putative active site [active]
996285011897	heme pocket [chemical binding]; other site
996285011898	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285011899	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285011900	active site
996285011901	I-site; other site
996285011902	metal binding site [ion binding]; metal-binding site
996285011903	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285011904	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
996285011905	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285011906	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285011907	DNA binding residues [nucleotide binding]
996285011908	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
996285011909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285011910	catalytic residue [active]
996285011911	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
996285011912	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
996285011913	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
996285011914	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
996285011915	IucA / IucC family; Region: IucA_IucC; pfam04183
996285011916	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
996285011917	siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950
996285011918	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
996285011919	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
996285011920	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
996285011921	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
996285011922	substrate binding pocket [chemical binding]; other site
996285011923	chain length determination region; other site
996285011924	substrate-Mg2+ binding site; other site
996285011925	catalytic residues [active]
996285011926	aspartate-rich region 1; other site
996285011927	active site lid residues [active]
996285011928	aspartate-rich region 2; other site
996285011929	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
996285011930	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
996285011931	TPP-binding site; other site
996285011932	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
996285011933	PYR/PP interface [polypeptide binding]; other site
996285011934	dimer interface [polypeptide binding]; other site
996285011935	TPP binding site [chemical binding]; other site
996285011936	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
996285011937	Uncharacterized conserved protein [Function unknown]; Region: COG1432
996285011938	LabA_like proteins; Region: LabA; cd10911
996285011939	putative metal binding site [ion binding]; other site
996285011940	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
996285011941	short chain dehydrogenase; Provisional; Region: PRK06181
996285011942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285011943	NAD(P) binding site [chemical binding]; other site
996285011944	active site
996285011945	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285011946	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285011947	substrate binding pocket [chemical binding]; other site
996285011948	membrane-bound complex binding site; other site
996285011949	hinge residues; other site
996285011950	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
996285011951	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
996285011952	ATP binding site [chemical binding]; other site
996285011953	putative Mg++ binding site [ion binding]; other site
996285011954	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285011955	nucleotide binding region [chemical binding]; other site
996285011956	ATP-binding site [chemical binding]; other site
996285011957	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
996285011958	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
996285011959	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
996285011960	Cation efflux family; Region: Cation_efflux; cl00316
996285011961	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
996285011962	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285011963	putative DNA binding site [nucleotide binding]; other site
996285011964	putative Zn2+ binding site [ion binding]; other site
996285011965	AsnC family; Region: AsnC_trans_reg; pfam01037
996285011966	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
996285011967	heme-binding site [chemical binding]; other site
996285011968	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
996285011969	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
996285011970	pseudouridine synthase; Region: TIGR00093
996285011971	active site
996285011972	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
996285011973	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
996285011974	putative ligand binding site [chemical binding]; other site
996285011975	HEAT repeats; Region: HEAT_2; pfam13646
996285011976	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
996285011977	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
996285011978	TM-ABC transporter signature motif; other site
996285011979	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
996285011980	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
996285011981	TM-ABC transporter signature motif; other site
996285011982	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
996285011983	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
996285011984	Walker A/P-loop; other site
996285011985	ATP binding site [chemical binding]; other site
996285011986	Q-loop/lid; other site
996285011987	ABC transporter signature motif; other site
996285011988	Walker B; other site
996285011989	D-loop; other site
996285011990	H-loop/switch region; other site
996285011991	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
996285011992	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
996285011993	Walker A/P-loop; other site
996285011994	ATP binding site [chemical binding]; other site
996285011995	Q-loop/lid; other site
996285011996	ABC transporter signature motif; other site
996285011997	Walker B; other site
996285011998	D-loop; other site
996285011999	H-loop/switch region; other site
996285012000	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
996285012001	magnesium-transporting ATPase; Provisional; Region: PRK15122
996285012002	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
996285012003	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
996285012004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285012005	motif II; other site
996285012006	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
996285012007	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
996285012008	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
996285012009	alpha-gamma subunit interface [polypeptide binding]; other site
996285012010	beta-gamma subunit interface [polypeptide binding]; other site
996285012011	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
996285012012	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285012013	Coenzyme A binding pocket [chemical binding]; other site
996285012014	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
996285012015	gamma-beta subunit interface [polypeptide binding]; other site
996285012016	alpha-beta subunit interface [polypeptide binding]; other site
996285012017	urease subunit alpha; Reviewed; Region: ureC; PRK13207
996285012018	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
996285012019	subunit interactions [polypeptide binding]; other site
996285012020	active site
996285012021	flap region; other site
996285012022	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
996285012023	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
996285012024	Na binding site [ion binding]; other site
996285012025	putative substrate binding site [chemical binding]; other site
996285012026	GAF domain; Region: GAF; pfam01590
996285012027	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285012028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285012029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285012030	dimer interface [polypeptide binding]; other site
996285012031	phosphorylation site [posttranslational modification]
996285012032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012033	ATP binding site [chemical binding]; other site
996285012034	Mg2+ binding site [ion binding]; other site
996285012035	G-X-G motif; other site
996285012036	hypothetical protein; Provisional; Region: PRK11019
996285012037	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
996285012038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285012039	putative substrate translocation pore; other site
996285012040	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
996285012041	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
996285012042	tetramer interface [polypeptide binding]; other site
996285012043	active site
996285012044	Mg2+/Mn2+ binding site [ion binding]; other site
996285012045	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
996285012046	EamA-like transporter family; Region: EamA; pfam00892
996285012047	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
996285012048	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
996285012049	dimer interface [polypeptide binding]; other site
996285012050	catalytic residues [active]
996285012051	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
996285012052	UreF; Region: UreF; pfam01730
996285012053	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
996285012054	G1 box; other site
996285012055	GTP/Mg2+ binding site [chemical binding]; other site
996285012056	G2 box; other site
996285012057	Switch I region; other site
996285012058	G3 box; other site
996285012059	Switch II region; other site
996285012060	G4 box; other site
996285012061	G5 box; other site
996285012062	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
996285012063	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
996285012064	AMP nucleosidase; Provisional; Region: PRK08292
996285012065	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
996285012066	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
996285012067	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
996285012068	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285012069	DNA-binding site [nucleotide binding]; DNA binding site
996285012070	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
996285012071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285012072	homodimer interface [polypeptide binding]; other site
996285012073	catalytic residue [active]
996285012074	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
996285012075	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
996285012076	tetramer interface [polypeptide binding]; other site
996285012077	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285012078	catalytic residue [active]
996285012079	Ion transport protein; Region: Ion_trans; pfam00520
996285012080	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
996285012081	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285012082	active site
996285012083	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
996285012084	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
996285012085	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285012086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285012087	dimer interface [polypeptide binding]; other site
996285012088	phosphorylation site [posttranslational modification]
996285012089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012090	ATP binding site [chemical binding]; other site
996285012091	Mg2+ binding site [ion binding]; other site
996285012092	G-X-G motif; other site
996285012093	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
996285012094	dimer interface [polypeptide binding]; other site
996285012095	substrate binding site [chemical binding]; other site
996285012096	ATP binding site [chemical binding]; other site
996285012097	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
996285012098	thiamine phosphate binding site [chemical binding]; other site
996285012099	active site
996285012100	pyrophosphate binding site [ion binding]; other site
996285012101	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
996285012102	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285012103	inhibitor-cofactor binding pocket; inhibition site
996285012104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285012105	catalytic residue [active]
996285012106	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
996285012107	Sel1-like repeats; Region: SEL1; smart00671
996285012108	Sel1-like repeats; Region: SEL1; smart00671
996285012109	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
996285012110	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
996285012111	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285012112	FeS/SAM binding site; other site
996285012113	TRAM domain; Region: TRAM; pfam01938
996285012114	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
996285012115	PhoH-like protein; Region: PhoH; pfam02562
996285012116	metal-binding heat shock protein; Provisional; Region: PRK00016
996285012117	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
996285012118	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
996285012119	Transporter associated domain; Region: CorC_HlyC; smart01091
996285012120	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
996285012121	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
996285012122	putative active site [active]
996285012123	catalytic triad [active]
996285012124	putative dimer interface [polypeptide binding]; other site
996285012125	Uncharacterized conserved protein [Function unknown]; Region: COG1434
996285012126	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
996285012127	putative active site [active]
996285012128	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
996285012129	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
996285012130	HIGH motif; other site
996285012131	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
996285012132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996285012133	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
996285012134	active site
996285012135	KMSKS motif; other site
996285012136	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
996285012137	tRNA binding surface [nucleotide binding]; other site
996285012138	Lipopolysaccharide-assembly; Region: LptE; cl01125
996285012139	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
996285012140	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
996285012141	Domain of unknown function; Region: DUF331; cl01149
996285012142	Transglycosylase SLT domain; Region: SLT_2; pfam13406
996285012143	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285012144	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285012145	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
996285012146	lipoyl synthase; Provisional; Region: PRK05481
996285012147	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285012148	FeS/SAM binding site; other site
996285012149	lipoate-protein ligase B; Provisional; Region: PRK14342
996285012150	Protein of unknown function (DUF493); Region: DUF493; cl01102
996285012151	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
996285012152	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
996285012153	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
996285012154	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
996285012155	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
996285012156	Sporulation related domain; Region: SPOR; pfam05036
996285012157	Transglycosylase SLT domain; Region: SLT_2; pfam13406
996285012158	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
996285012159	N-acetyl-D-glucosamine binding site [chemical binding]; other site
996285012160	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
996285012161	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
996285012162	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
996285012163	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
996285012164	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
996285012165	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
996285012166	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
996285012167	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
996285012168	active site
996285012169	(T/H)XGH motif; other site
996285012170	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
996285012171	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
996285012172	putative catalytic cysteine [active]
996285012173	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
996285012174	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
996285012175	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
996285012176	active site
996285012177	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
996285012178	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
996285012179	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
996285012180	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
996285012181	putative active site [active]
996285012182	putative catalytic site [active]
996285012183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
996285012184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
996285012185	MORN repeat; Region: MORN; cl14787
996285012186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
996285012187	Peptidase C13 family; Region: Peptidase_C13; cl02159
996285012188	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
996285012189	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
996285012190	NAD binding site [chemical binding]; other site
996285012191	active site
996285012192	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
996285012193	catalytic site [active]
996285012194	putative active site [active]
996285012195	putative substrate binding site [chemical binding]; other site
996285012196	dimer interface [polypeptide binding]; other site
996285012197	Methyltransferase domain; Region: Methyltransf_18; pfam12847
996285012198	S-adenosylmethionine binding site [chemical binding]; other site
996285012199	GTPase RsgA; Reviewed; Region: PRK12288
996285012200	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
996285012201	RNA binding site [nucleotide binding]; other site
996285012202	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
996285012203	GTPase/Zn-binding domain interface [polypeptide binding]; other site
996285012204	GTP/Mg2+ binding site [chemical binding]; other site
996285012205	G4 box; other site
996285012206	G5 box; other site
996285012207	G1 box; other site
996285012208	Switch I region; other site
996285012209	G2 box; other site
996285012210	G3 box; other site
996285012211	Switch II region; other site
996285012212	flagellar motor protein MotB; Validated; Region: motB; PRK09041
996285012213	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
996285012214	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
996285012215	ligand binding site [chemical binding]; other site
996285012216	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
996285012217	flagellar motor protein MotA; Validated; Region: PRK09110
996285012218	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
996285012219	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
996285012220	active site residue [active]
996285012221	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
996285012222	active site residue [active]
996285012223	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
996285012224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012225	active site
996285012226	phosphorylation site [posttranslational modification]
996285012227	intermolecular recognition site; other site
996285012228	dimerization interface [polypeptide binding]; other site
996285012229	PAS domain; Region: PAS_8; pfam13188
996285012230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285012231	putative active site [active]
996285012232	heme pocket [chemical binding]; other site
996285012233	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285012234	metal binding site [ion binding]; metal-binding site
996285012235	active site
996285012236	I-site; other site
996285012237	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285012238	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
996285012239	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
996285012240	tetramer interface [polypeptide binding]; other site
996285012241	catalytic Zn binding site [ion binding]; other site
996285012242	NADP binding site [chemical binding]; other site
996285012243	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
996285012244	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
996285012245	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
996285012246	phosphoserine phosphatase SerB; Region: serB; TIGR00338
996285012247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
996285012248	motif II; other site
996285012249	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
996285012250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
996285012251	Protein of unknown function (DUF330); Region: DUF330; pfam03886
996285012252	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
996285012253	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
996285012254	CAP-like domain; other site
996285012255	active site
996285012256	primary dimer interface [polypeptide binding]; other site
996285012257	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
996285012258	catalytic motif [active]
996285012259	Catalytic residue [active]
996285012260	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
996285012261	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
996285012262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012263	ATP binding site [chemical binding]; other site
996285012264	Mg2+ binding site [ion binding]; other site
996285012265	G-X-G motif; other site
996285012266	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
996285012267	anchoring element; other site
996285012268	dimer interface [polypeptide binding]; other site
996285012269	ATP binding site [chemical binding]; other site
996285012270	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
996285012271	active site
996285012272	metal binding site [ion binding]; metal-binding site
996285012273	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
996285012274	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
996285012275	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
996285012276	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
996285012277	active site
996285012278	metal binding site [ion binding]; metal-binding site
996285012279	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
996285012280	hexamer interface [polypeptide binding]; other site
996285012281	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
996285012282	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
996285012283	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
996285012284	dimer interface [polypeptide binding]; other site
996285012285	ADP-ribose binding site [chemical binding]; other site
996285012286	active site
996285012287	nudix motif; other site
996285012288	metal binding site [ion binding]; metal-binding site
996285012289	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
996285012290	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
996285012291	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
996285012292	NAD(P) binding site [chemical binding]; other site
996285012293	homodimer interface [polypeptide binding]; other site
996285012294	substrate binding site [chemical binding]; other site
996285012295	active site
996285012296	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
996285012297	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
996285012298	Mg++ binding site [ion binding]; other site
996285012299	putative catalytic motif [active]
996285012300	putative substrate binding site [chemical binding]; other site
996285012301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285012302	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
996285012303	NAD(P) binding site [chemical binding]; other site
996285012304	active site
996285012305	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
996285012306	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
996285012307	ligand-binding site [chemical binding]; other site
996285012308	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
996285012309	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
996285012310	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
996285012311	Walker A motif; other site
996285012312	ATP binding site [chemical binding]; other site
996285012313	Walker B motif; other site
996285012314	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
996285012315	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
996285012316	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
996285012317	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
996285012318	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
996285012319	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
996285012320	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
996285012321	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
996285012322	type II secretion system protein D; Region: type_II_gspD; TIGR02517
996285012323	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
996285012324	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
996285012325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
996285012326	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
996285012327	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
996285012328	active site
996285012329	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
996285012330	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285012331	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
996285012332	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
996285012333	Walker A/P-loop; other site
996285012334	ATP binding site [chemical binding]; other site
996285012335	Q-loop/lid; other site
996285012336	ABC transporter signature motif; other site
996285012337	Walker B; other site
996285012338	D-loop; other site
996285012339	H-loop/switch region; other site
996285012340	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
996285012341	putative carbohydrate binding site [chemical binding]; other site
996285012342	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
996285012343	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
996285012344	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
996285012345	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
996285012346	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
996285012347	substrate binding site; other site
996285012348	tetramer interface; other site
996285012349	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
996285012350	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
996285012351	NADP binding site [chemical binding]; other site
996285012352	active site
996285012353	putative substrate binding site [chemical binding]; other site
996285012354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285012355	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
996285012356	ThiC-associated domain; Region: ThiC-associated; pfam13667
996285012357	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
996285012358	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
996285012359	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
996285012360	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
996285012361	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
996285012362	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
996285012363	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
996285012364	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
996285012365	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
996285012366	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
996285012367	active site
996285012368	catalytic tetrad [active]
996285012369	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
996285012370	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
996285012371	putative ribose interaction site [chemical binding]; other site
996285012372	putative ADP binding site [chemical binding]; other site
996285012373	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
996285012374	active site
996285012375	nucleotide binding site [chemical binding]; other site
996285012376	HIGH motif; other site
996285012377	KMSKS motif; other site
996285012378	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
996285012379	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
996285012380	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
996285012381	Walker A/P-loop; other site
996285012382	ATP binding site [chemical binding]; other site
996285012383	Q-loop/lid; other site
996285012384	ABC transporter signature motif; other site
996285012385	Walker B; other site
996285012386	D-loop; other site
996285012387	H-loop/switch region; other site
996285012388	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
996285012389	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285012390	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
996285012391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285012392	putative ADP-binding pocket [chemical binding]; other site
996285012393	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
996285012394	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
996285012395	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
996285012396	active site
996285012397	ATP binding site [chemical binding]; other site
996285012398	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
996285012399	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
996285012400	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
996285012401	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
996285012402	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
996285012403	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
996285012404	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
996285012405	putative active site [active]
996285012406	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
996285012407	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
996285012408	putative active site [active]
996285012409	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
996285012410	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
996285012411	homodimer interface [polypeptide binding]; other site
996285012412	substrate-cofactor binding pocket; other site
996285012413	catalytic residue [active]
996285012414	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
996285012415	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996285012416	metal binding triad; other site
996285012417	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
996285012418	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996285012419	metal binding triad; other site
996285012420	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
996285012421	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
996285012422	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
996285012423	dimer interface [polypeptide binding]; other site
996285012424	TPP-binding site [chemical binding]; other site
996285012425	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
996285012426	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285012427	E3 interaction surface; other site
996285012428	lipoyl attachment site [posttranslational modification]; other site
996285012429	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285012430	E3 interaction surface; other site
996285012431	lipoyl attachment site [posttranslational modification]; other site
996285012432	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
996285012433	E3 interaction surface; other site
996285012434	lipoyl attachment site [posttranslational modification]; other site
996285012435	e3 binding domain; Region: E3_binding; pfam02817
996285012436	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
996285012437	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285012438	GAF domain; Region: GAF; pfam01590
996285012439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285012440	PAS domain; Region: PAS_9; pfam13426
996285012441	putative active site [active]
996285012442	heme pocket [chemical binding]; other site
996285012443	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285012444	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285012445	metal binding site [ion binding]; metal-binding site
996285012446	active site
996285012447	I-site; other site
996285012448	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285012449	methionine sulfoxide reductase A; Provisional; Region: PRK00058
996285012450	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
996285012451	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
996285012452	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285012453	active site
996285012454	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
996285012455	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285012456	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285012457	metal binding site [ion binding]; metal-binding site
996285012458	active site
996285012459	I-site; other site
996285012460	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
996285012461	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
996285012462	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285012463	active site
996285012464	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
996285012465	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
996285012466	AAA domain; Region: AAA_26; pfam13500
996285012467	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
996285012468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285012469	S-adenosylmethionine binding site [chemical binding]; other site
996285012470	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
996285012471	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
996285012472	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
996285012473	substrate-cofactor binding pocket; other site
996285012474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285012475	catalytic residue [active]
996285012476	biotin synthase; Provisional; Region: PRK15108
996285012477	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285012478	FeS/SAM binding site; other site
996285012479	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
996285012480	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
996285012481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285012482	active site
996285012483	serine/threonine protein kinase; Provisional; Region: PRK11768
996285012484	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
996285012485	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
996285012486	Nitronate monooxygenase; Region: NMO; pfam03060
996285012487	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
996285012488	FMN binding site [chemical binding]; other site
996285012489	substrate binding site [chemical binding]; other site
996285012490	putative catalytic residue [active]
996285012491	beta-carotene hydroxylase; Region: PLN02601
996285012492	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
996285012493	active site lid residues [active]
996285012494	substrate binding pocket [chemical binding]; other site
996285012495	catalytic residues [active]
996285012496	substrate-Mg2+ binding site; other site
996285012497	aspartate-rich region 1; other site
996285012498	aspartate-rich region 2; other site
996285012499	phytoene desaturase; Region: crtI_fam; TIGR02734
996285012500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285012501	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
996285012502	lycopene cyclase; Region: lycopene_cycl; TIGR01789
996285012503	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
996285012504	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
996285012505	active site
996285012506	TDP-binding site; other site
996285012507	acceptor substrate-binding pocket; other site
996285012508	homodimer interface [polypeptide binding]; other site
996285012509	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
996285012510	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
996285012511	homotetramer interface [polypeptide binding]; other site
996285012512	FMN binding site [chemical binding]; other site
996285012513	homodimer contacts [polypeptide binding]; other site
996285012514	putative active site [active]
996285012515	putative substrate binding site [chemical binding]; other site
996285012516	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
996285012517	substrate binding pocket [chemical binding]; other site
996285012518	substrate-Mg2+ binding site; other site
996285012519	aspartate-rich region 1; other site
996285012520	aspartate-rich region 2; other site
996285012521	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
996285012522	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
996285012523	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
996285012524	active site
996285012525	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
996285012526	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
996285012527	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
996285012528	TrkA-C domain; Region: TrkA_C; pfam02080
996285012529	Transporter associated domain; Region: CorC_HlyC; smart01091
996285012530	hypothetical protein; Provisional; Region: PRK11281
996285012531	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
996285012532	Mechanosensitive ion channel; Region: MS_channel; pfam00924
996285012533	Uncharacterized conserved protein [Function unknown]; Region: COG0397
996285012534	hypothetical protein; Validated; Region: PRK00029
996285012535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012536	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012537	active site
996285012538	phosphorylation site [posttranslational modification]
996285012539	intermolecular recognition site; other site
996285012540	dimerization interface [polypeptide binding]; other site
996285012541	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285012542	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285012543	dimer interface [polypeptide binding]; other site
996285012544	phosphorylation site [posttranslational modification]
996285012545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012546	ATP binding site [chemical binding]; other site
996285012547	Mg2+ binding site [ion binding]; other site
996285012548	G-X-G motif; other site
996285012549	CheB methylesterase; Region: CheB_methylest; pfam01339
996285012550	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
996285012551	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
996285012552	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
996285012553	CHASE3 domain; Region: CHASE3; pfam05227
996285012554	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
996285012555	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
996285012556	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285012557	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285012558	dimer interface [polypeptide binding]; other site
996285012559	phosphorylation site [posttranslational modification]
996285012560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012561	ATP binding site [chemical binding]; other site
996285012562	Mg2+ binding site [ion binding]; other site
996285012563	G-X-G motif; other site
996285012564	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012566	active site
996285012567	phosphorylation site [posttranslational modification]
996285012568	intermolecular recognition site; other site
996285012569	dimerization interface [polypeptide binding]; other site
996285012570	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285012571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012572	active site
996285012573	phosphorylation site [posttranslational modification]
996285012574	intermolecular recognition site; other site
996285012575	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012577	active site
996285012578	phosphorylation site [posttranslational modification]
996285012579	intermolecular recognition site; other site
996285012580	dimerization interface [polypeptide binding]; other site
996285012581	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
996285012582	short chain dehydrogenase; Provisional; Region: PRK07109
996285012583	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
996285012584	putative NAD(P) binding site [chemical binding]; other site
996285012585	active site
996285012586	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
996285012587	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
996285012588	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
996285012589	dimer interface [polypeptide binding]; other site
996285012590	active site residues [active]
996285012591	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
996285012592	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
996285012593	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
996285012594	Water Stress and Hypersensitive response; Region: WHy; smart00769
996285012595	outer membrane porin, OprD family; Region: OprD; pfam03573
996285012596	outer membrane porin, OprD family; Region: OprD; pfam03573
996285012597	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
996285012598	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
996285012599	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
996285012600	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
996285012601	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
996285012602	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285012603	N-terminal plug; other site
996285012604	ligand-binding site [chemical binding]; other site
996285012605	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
996285012606	active site
996285012607	catalytic residues [active]
996285012608	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
996285012609	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
996285012610	putative ligand binding site [chemical binding]; other site
996285012611	NAD binding site [chemical binding]; other site
996285012612	catalytic site [active]
996285012613	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
996285012614	FAD binding domain; Region: FAD_binding_4; pfam01565
996285012615	galactarate dehydratase; Region: galactar-dH20; TIGR03248
996285012616	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
996285012617	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
996285012618	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
996285012619	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
996285012620	active site
996285012621	tetramer interface [polypeptide binding]; other site
996285012622	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
996285012623	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
996285012624	NAD(P) binding site [chemical binding]; other site
996285012625	catalytic residues [active]
996285012626	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
996285012627	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
996285012628	putative active site [active]
996285012629	catalytic residue [active]
996285012630	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
996285012631	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
996285012632	active site
996285012633	tetramer interface [polypeptide binding]; other site
996285012634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
996285012635	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
996285012636	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
996285012637	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
996285012638	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
996285012639	active site pocket [active]
996285012640	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
996285012641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285012642	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285012643	dimerization interface [polypeptide binding]; other site
996285012644	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
996285012645	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
996285012646	active site pocket [active]
996285012647	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
996285012648	active site
996285012649	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
996285012650	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
996285012651	conserved cys residue [active]
996285012652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
996285012653	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
996285012654	Transcriptional regulators [Transcription]; Region: PurR; COG1609
996285012655	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
996285012656	DNA binding site [nucleotide binding]
996285012657	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
996285012658	putative ligand binding site [chemical binding]; other site
996285012659	putative dimerization interface [polypeptide binding]; other site
996285012660	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
996285012661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285012662	active site
996285012663	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
996285012664	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
996285012665	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
996285012666	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
996285012667	DctM-like transporters; Region: DctM; pfam06808
996285012668	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
996285012669	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
996285012670	Transcriptional regulators [Transcription]; Region: FadR; COG2186
996285012671	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
996285012672	DNA-binding site [nucleotide binding]; DNA binding site
996285012673	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
996285012674	Trehalase; Region: Trehalase; cl17346
996285012675	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
996285012676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
996285012677	NAD(P) binding site [chemical binding]; other site
996285012678	active site
996285012679	Predicted permeases [General function prediction only]; Region: RarD; COG2962
996285012680	EamA-like transporter family; Region: EamA; pfam00892
996285012681	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
996285012682	ACT domain; Region: ACT_6; pfam13740
996285012683	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
996285012684	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
996285012685	active site
996285012686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285012687	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285012688	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
996285012689	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
996285012690	ligand binding site [chemical binding]; other site
996285012691	flexible hinge region; other site
996285012692	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
996285012693	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
996285012694	metal binding triad; other site
996285012695	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
996285012696	active site
996285012697	catalytic site [active]
996285012698	substrate binding site [chemical binding]; other site
996285012699	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
996285012700	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
996285012701	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
996285012702	Na binding site [ion binding]; other site
996285012703	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
996285012704	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
996285012705	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
996285012706	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996285012707	ATP binding site [chemical binding]; other site
996285012708	Mg++ binding site [ion binding]; other site
996285012709	motif III; other site
996285012710	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285012711	nucleotide binding region [chemical binding]; other site
996285012712	ATP-binding site [chemical binding]; other site
996285012713	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
996285012714	putative RNA binding site [nucleotide binding]; other site
996285012715	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
996285012716	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
996285012717	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
996285012718	multiple promoter invertase; Provisional; Region: mpi; PRK13413
996285012719	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
996285012720	catalytic residues [active]
996285012721	catalytic nucleophile [active]
996285012722	Presynaptic Site I dimer interface [polypeptide binding]; other site
996285012723	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
996285012724	Synaptic Flat tetramer interface [polypeptide binding]; other site
996285012725	Synaptic Site I dimer interface [polypeptide binding]; other site
996285012726	DNA binding site [nucleotide binding]
996285012727	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
996285012728	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285012729	Outer membrane efflux protein; Region: OEP; pfam02321
996285012730	Outer membrane efflux protein; Region: OEP; pfam02321
996285012731	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
996285012732	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
996285012733	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
996285012734	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285012735	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
996285012736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012737	active site
996285012738	phosphorylation site [posttranslational modification]
996285012739	intermolecular recognition site; other site
996285012740	dimerization interface [polypeptide binding]; other site
996285012741	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285012742	DNA binding site [nucleotide binding]
996285012743	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
996285012744	HAMP domain; Region: HAMP; pfam00672
996285012745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285012746	dimer interface [polypeptide binding]; other site
996285012747	phosphorylation site [posttranslational modification]
996285012748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012749	ATP binding site [chemical binding]; other site
996285012750	Mg2+ binding site [ion binding]; other site
996285012751	G-X-G motif; other site
996285012752	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
996285012753	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
996285012754	Chromate transporter; Region: Chromate_transp; pfam02417
996285012755	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
996285012756	H+ Antiporter protein; Region: 2A0121; TIGR00900
996285012757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
996285012758	putative substrate translocation pore; other site
996285012759	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
996285012760	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
996285012761	putative homodimer interface [polypeptide binding]; other site
996285012762	putative homotetramer interface [polypeptide binding]; other site
996285012763	putative metal binding site [ion binding]; other site
996285012764	putative homodimer-homodimer interface [polypeptide binding]; other site
996285012765	putative allosteric switch controlling residues; other site
996285012766	Predicted membrane protein [Function unknown]; Region: COG1238
996285012767	TraX protein; Region: TraX; cl05434
996285012768	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
996285012769	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
996285012770	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
996285012771	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
996285012772	metal-binding site [ion binding]
996285012773	MerT mercuric transport protein; Region: MerT; cl03578
996285012774	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
996285012775	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
996285012776	DNA binding residues [nucleotide binding]
996285012777	dimer interface [polypeptide binding]; other site
996285012778	mercury binding site [ion binding]; other site
996285012779	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285012780	substrate binding pocket [chemical binding]; other site
996285012781	membrane-bound complex binding site; other site
996285012782	hinge residues; other site
996285012783	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
996285012784	HI0933-like protein; Region: HI0933_like; pfam03486
996285012785	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
996285012786	heme-binding site [chemical binding]; other site
996285012787	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285012788	PAS fold; Region: PAS_3; pfam08447
996285012789	putative active site [active]
996285012790	heme pocket [chemical binding]; other site
996285012791	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285012792	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285012793	metal binding site [ion binding]; metal-binding site
996285012794	active site
996285012795	I-site; other site
996285012796	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285012797	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
996285012798	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
996285012799	Methyltransferase domain; Region: Methyltransf_23; pfam13489
996285012800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285012801	S-adenosylmethionine binding site [chemical binding]; other site
996285012802	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012804	active site
996285012805	phosphorylation site [posttranslational modification]
996285012806	intermolecular recognition site; other site
996285012807	dimerization interface [polypeptide binding]; other site
996285012808	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
996285012809	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
996285012810	intersubunit interface [polypeptide binding]; other site
996285012811	active site
996285012812	zinc binding site [ion binding]; other site
996285012813	Na+ binding site [ion binding]; other site
996285012814	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
996285012815	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
996285012816	Phosphoglycerate kinase; Region: PGK; pfam00162
996285012817	substrate binding site [chemical binding]; other site
996285012818	hinge regions; other site
996285012819	ADP binding site [chemical binding]; other site
996285012820	catalytic site [active]
996285012821	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
996285012822	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
996285012823	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
996285012824	transketolase; Reviewed; Region: PRK12753
996285012825	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
996285012826	TPP-binding site [chemical binding]; other site
996285012827	dimer interface [polypeptide binding]; other site
996285012828	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
996285012829	PYR/PP interface [polypeptide binding]; other site
996285012830	dimer interface [polypeptide binding]; other site
996285012831	TPP binding site [chemical binding]; other site
996285012832	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
996285012833	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
996285012834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285012835	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
996285012836	dimerization interface [polypeptide binding]; other site
996285012837	substrate binding pocket [chemical binding]; other site
996285012838	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
996285012839	substrate binding pocket [chemical binding]; other site
996285012840	active site
996285012841	iron coordination sites [ion binding]; other site
996285012842	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
996285012843	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285012844	putative DNA binding site [nucleotide binding]; other site
996285012845	putative Zn2+ binding site [ion binding]; other site
996285012846	Methyltransferase domain; Region: Methyltransf_31; pfam13847
996285012847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285012848	S-adenosylmethionine binding site [chemical binding]; other site
996285012849	S-adenosylmethionine synthetase; Validated; Region: PRK05250
996285012850	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
996285012851	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
996285012852	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
996285012853	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
996285012854	ABC-2 type transporter; Region: ABC2_membrane; cl17235
996285012855	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
996285012856	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
996285012857	Walker A/P-loop; other site
996285012858	ATP binding site [chemical binding]; other site
996285012859	Q-loop/lid; other site
996285012860	ABC transporter signature motif; other site
996285012861	Walker B; other site
996285012862	D-loop; other site
996285012863	H-loop/switch region; other site
996285012864	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
996285012865	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
996285012866	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
996285012867	FAD binding pocket [chemical binding]; other site
996285012868	FAD binding motif [chemical binding]; other site
996285012869	phosphate binding motif [ion binding]; other site
996285012870	beta-alpha-beta structure motif; other site
996285012871	NAD binding pocket [chemical binding]; other site
996285012872	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
996285012873	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
996285012874	nucleotide binding pocket [chemical binding]; other site
996285012875	K-X-D-G motif; other site
996285012876	catalytic site [active]
996285012877	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
996285012878	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
996285012879	Cytochrome C' Region: Cytochrom_C_2; pfam01322
996285012880	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
996285012881	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
996285012882	homotetramer interface [polypeptide binding]; other site
996285012883	ligand binding site [chemical binding]; other site
996285012884	catalytic site [active]
996285012885	NAD binding site [chemical binding]; other site
996285012886	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
996285012887	FAD binding site [chemical binding]; other site
996285012888	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
996285012889	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
996285012890	ATP binding site [chemical binding]; other site
996285012891	Mg++ binding site [ion binding]; other site
996285012892	motif III; other site
996285012893	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
996285012894	nucleotide binding region [chemical binding]; other site
996285012895	ATP-binding site [chemical binding]; other site
996285012896	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
996285012897	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
996285012898	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
996285012899	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
996285012900	HlyD family secretion protein; Region: HlyD_3; pfam13437
996285012901	hypothetical protein; Provisional; Region: PRK03757
996285012902	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
996285012903	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
996285012904	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
996285012905	inhibitor-cofactor binding pocket; inhibition site
996285012906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285012907	catalytic residue [active]
996285012908	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
996285012909	RNA methyltransferase, RsmE family; Region: TIGR00046
996285012910	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
996285012911	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
996285012912	CheB methylesterase; Region: CheB_methylest; pfam01339
996285012913	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285012914	putative binding surface; other site
996285012915	active site
996285012916	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285012917	putative binding surface; other site
996285012918	active site
996285012919	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285012920	putative binding surface; other site
996285012921	active site
996285012922	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285012923	putative binding surface; other site
996285012924	active site
996285012925	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
996285012926	putative binding surface; other site
996285012927	active site
996285012928	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
996285012929	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
996285012930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285012931	ATP binding site [chemical binding]; other site
996285012932	Mg2+ binding site [ion binding]; other site
996285012933	G-X-G motif; other site
996285012934	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
996285012935	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012937	active site
996285012938	phosphorylation site [posttranslational modification]
996285012939	intermolecular recognition site; other site
996285012940	dimerization interface [polypeptide binding]; other site
996285012941	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
996285012942	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
996285012943	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
996285012944	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
996285012945	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285012946	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285012947	dimer interface [polypeptide binding]; other site
996285012948	putative CheW interface [polypeptide binding]; other site
996285012949	Transposase domain (DUF772); Region: DUF772; pfam05598
996285012950	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
996285012951	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
996285012952	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
996285012953	putative CheA interaction surface; other site
996285012954	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012956	active site
996285012957	phosphorylation site [posttranslational modification]
996285012958	intermolecular recognition site; other site
996285012959	dimerization interface [polypeptide binding]; other site
996285012960	Response regulator receiver domain; Region: Response_reg; pfam00072
996285012961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285012962	active site
996285012963	phosphorylation site [posttranslational modification]
996285012964	intermolecular recognition site; other site
996285012965	dimerization interface [polypeptide binding]; other site
996285012966	glutathione synthetase; Provisional; Region: PRK05246
996285012967	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
996285012968	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
996285012969	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
996285012970	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
996285012971	hypothetical protein; Validated; Region: PRK00228
996285012972	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
996285012973	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
996285012974	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
996285012975	active site
996285012976	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
996285012977	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
996285012978	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
996285012979	dihydroorotase; Validated; Region: pyrC; PRK09357
996285012980	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
996285012981	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
996285012982	active site
996285012983	TM2 domain; Region: TM2; cl00984
996285012984	TM2 domain; Region: TM2; cl00984
996285012985	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
996285012986	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285012987	FeS/SAM binding site; other site
996285012988	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
996285012989	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
996285012990	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
996285012991	Walker A motif; other site
996285012992	ATP binding site [chemical binding]; other site
996285012993	Walker B motif; other site
996285012994	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
996285012995	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
996285012996	Walker A motif; other site
996285012997	ATP binding site [chemical binding]; other site
996285012998	Walker B motif; other site
996285012999	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
996285013000	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
996285013001	catalytic residue [active]
996285013002	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
996285013003	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
996285013004	YGGT family; Region: YGGT; pfam02325
996285013005	YGGT family; Region: YGGT; pfam02325
996285013006	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
996285013007	Dynamin family; Region: Dynamin_N; pfam00350
996285013008	G1 box; other site
996285013009	GTP/Mg2+ binding site [chemical binding]; other site
996285013010	G2 box; other site
996285013011	Switch I region; other site
996285013012	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
996285013013	G3 box; other site
996285013014	Switch II region; other site
996285013015	GTP/Mg2+ binding site [chemical binding]; other site
996285013016	G4 box; other site
996285013017	G5 box; other site
996285013018	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
996285013019	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
996285013020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285013021	S-adenosylmethionine binding site [chemical binding]; other site
996285013022	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
996285013023	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
996285013024	active site
996285013025	dimerization interface [polypeptide binding]; other site
996285013026	HemN family oxidoreductase; Provisional; Region: PRK05660
996285013027	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285013028	FeS/SAM binding site; other site
996285013029	HemN C-terminal domain; Region: HemN_C; pfam06969
996285013030	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
996285013031	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
996285013032	arginine deiminase; Provisional; Region: PRK01388
996285013033	ornithine carbamoyltransferase; Validated; Region: PRK02102
996285013034	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
996285013035	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
996285013036	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
996285013037	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
996285013038	putative substrate binding site [chemical binding]; other site
996285013039	nucleotide binding site [chemical binding]; other site
996285013040	nucleotide binding site [chemical binding]; other site
996285013041	homodimer interface [polypeptide binding]; other site
996285013042	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
996285013043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285013044	S-adenosylmethionine binding site [chemical binding]; other site
996285013045	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285013046	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285013047	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
996285013048	ThiS interaction site; other site
996285013049	putative active site [active]
996285013050	tetramer interface [polypeptide binding]; other site
996285013051	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
996285013052	thiS-thiF/thiG interaction site; other site
996285013053	Protein of unknown function (DUF423); Region: DUF423; pfam04241
996285013054	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
996285013055	Transglycosylase; Region: Transgly; cl17702
996285013056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013057	PAS domain; Region: PAS_9; pfam13426
996285013058	putative active site [active]
996285013059	heme pocket [chemical binding]; other site
996285013060	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285013061	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285013062	metal binding site [ion binding]; metal-binding site
996285013063	active site
996285013064	I-site; other site
996285013065	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
996285013066	CHASE domain; Region: CHASE; pfam03924
996285013067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013068	PAS fold; Region: PAS_3; pfam08447
996285013069	putative active site [active]
996285013070	heme pocket [chemical binding]; other site
996285013071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285013072	dimer interface [polypeptide binding]; other site
996285013073	phosphorylation site [posttranslational modification]
996285013074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285013075	ATP binding site [chemical binding]; other site
996285013076	Mg2+ binding site [ion binding]; other site
996285013077	G-X-G motif; other site
996285013078	Response regulator receiver domain; Region: Response_reg; pfam00072
996285013079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285013080	active site
996285013081	phosphorylation site [posttranslational modification]
996285013082	intermolecular recognition site; other site
996285013083	dimerization interface [polypeptide binding]; other site
996285013084	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
996285013085	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
996285013086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285013087	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285013088	DNA binding residues [nucleotide binding]
996285013089	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
996285013090	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
996285013091	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
996285013092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285013093	Walker A/P-loop; other site
996285013094	ATP binding site [chemical binding]; other site
996285013095	Q-loop/lid; other site
996285013096	ABC transporter signature motif; other site
996285013097	Walker B; other site
996285013098	D-loop; other site
996285013099	H-loop/switch region; other site
996285013100	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
996285013101	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
996285013102	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
996285013103	P loop; other site
996285013104	GTP binding site [chemical binding]; other site
996285013105	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
996285013106	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
996285013107	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
996285013108	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
996285013109	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
996285013110	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
996285013111	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
996285013112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285013113	S-adenosylmethionine binding site [chemical binding]; other site
996285013114	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
996285013115	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
996285013116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
996285013117	Bacterial transcriptional repressor; Region: TetR; pfam13972
996285013118	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
996285013119	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
996285013120	NAD(P) binding site [chemical binding]; other site
996285013121	catalytic residues [active]
996285013122	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
996285013123	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
996285013124	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
996285013125	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
996285013126	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
996285013127	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
996285013128	active site
996285013129	(T/H)XGH motif; other site
996285013130	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
996285013131	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
996285013132	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
996285013133	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
996285013134	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
996285013135	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
996285013136	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
996285013137	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
996285013138	DNA binding site [nucleotide binding]
996285013139	catalytic residue [active]
996285013140	H2TH interface [polypeptide binding]; other site
996285013141	putative catalytic residues [active]
996285013142	turnover-facilitating residue; other site
996285013143	intercalation triad [nucleotide binding]; other site
996285013144	8OG recognition residue [nucleotide binding]; other site
996285013145	putative reading head residues; other site
996285013146	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
996285013147	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
996285013148	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
996285013149	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
996285013150	intracellular protease, PfpI family; Region: PfpI; TIGR01382
996285013151	proposed catalytic triad [active]
996285013152	conserved cys residue [active]
996285013153	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
996285013154	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
996285013155	putative RNA binding site [nucleotide binding]; other site
996285013156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
996285013157	S-adenosylmethionine binding site [chemical binding]; other site
996285013158	chlorophyllase; Region: PLN00021
996285013159	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
996285013160	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
996285013161	Predicted dehydrogenase [General function prediction only]; Region: COG0579
996285013162	hydroxyglutarate oxidase; Provisional; Region: PRK11728
996285013163	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
996285013164	active site
996285013165	metal binding site [ion binding]; metal-binding site
996285013166	homotetramer interface [polypeptide binding]; other site
996285013167	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
996285013168	Uncharacterized conserved protein [Function unknown]; Region: COG1284
996285013169	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
996285013170	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
996285013171	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
996285013172	folate binding site [chemical binding]; other site
996285013173	NADP+ binding site [chemical binding]; other site
996285013174	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
996285013175	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
996285013176	putative active site [active]
996285013177	catalytic site [active]
996285013178	putative metal binding site [ion binding]; other site
996285013179	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
996285013180	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
996285013181	G1 box; other site
996285013182	GTP/Mg2+ binding site [chemical binding]; other site
996285013183	G2 box; other site
996285013184	Switch I region; other site
996285013185	G3 box; other site
996285013186	Switch II region; other site
996285013187	G4 box; other site
996285013188	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
996285013189	EamA-like transporter family; Region: EamA; pfam00892
996285013190	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
996285013191	EamA-like transporter family; Region: EamA; pfam00892
996285013192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285013193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285013194	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
996285013195	putative effector binding pocket; other site
996285013196	dimerization interface [polypeptide binding]; other site
996285013197	transcriptional regulator PhoU; Provisional; Region: PRK11115
996285013198	PhoU domain; Region: PhoU; pfam01895
996285013199	PhoU domain; Region: PhoU; pfam01895
996285013200	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
996285013201	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
996285013202	Walker A/P-loop; other site
996285013203	ATP binding site [chemical binding]; other site
996285013204	Q-loop/lid; other site
996285013205	ABC transporter signature motif; other site
996285013206	Walker B; other site
996285013207	D-loop; other site
996285013208	H-loop/switch region; other site
996285013209	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
996285013210	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
996285013211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285013212	dimer interface [polypeptide binding]; other site
996285013213	conserved gate region; other site
996285013214	putative PBP binding loops; other site
996285013215	ABC-ATPase subunit interface; other site
996285013216	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
996285013217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285013218	dimer interface [polypeptide binding]; other site
996285013219	conserved gate region; other site
996285013220	putative PBP binding loops; other site
996285013221	ABC-ATPase subunit interface; other site
996285013222	PBP superfamily domain; Region: PBP_like_2; cl17296
996285013223	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
996285013224	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
996285013225	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285013226	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285013227	metal binding site [ion binding]; metal-binding site
996285013228	active site
996285013229	I-site; other site
996285013230	Predicted permeases [General function prediction only]; Region: COG0679
996285013231	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
996285013232	AAA domain; Region: AAA_30; pfam13604
996285013233	Family description; Region: UvrD_C_2; pfam13538
996285013234	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
996285013235	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
996285013236	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
996285013237	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
996285013238	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
996285013239	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
996285013240	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
996285013241	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
996285013242	PhoU domain; Region: PhoU; pfam01895
996285013243	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
996285013244	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
996285013245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
996285013246	outer membrane porin, OprD family; Region: OprD; pfam03573
996285013247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
996285013248	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
996285013249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285013250	active site
996285013251	phosphorylation site [posttranslational modification]
996285013252	intermolecular recognition site; other site
996285013253	dimerization interface [polypeptide binding]; other site
996285013254	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
996285013255	DNA binding site [nucleotide binding]
996285013256	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
996285013257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285013258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
996285013259	dimerization interface [polypeptide binding]; other site
996285013260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285013261	dimer interface [polypeptide binding]; other site
996285013262	phosphorylation site [posttranslational modification]
996285013263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285013264	ATP binding site [chemical binding]; other site
996285013265	Mg2+ binding site [ion binding]; other site
996285013266	G-X-G motif; other site
996285013267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013268	PAS domain; Region: PAS_9; pfam13426
996285013269	putative active site [active]
996285013270	heme pocket [chemical binding]; other site
996285013271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
996285013272	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285013273	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285013274	dimer interface [polypeptide binding]; other site
996285013275	putative CheW interface [polypeptide binding]; other site
996285013276	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013277	PAS domain; Region: PAS_9; pfam13426
996285013278	putative active site [active]
996285013279	heme pocket [chemical binding]; other site
996285013280	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285013281	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285013282	dimer interface [polypeptide binding]; other site
996285013283	putative CheW interface [polypeptide binding]; other site
996285013284	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285013285	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285013286	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
996285013287	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
996285013288	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
996285013289	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
996285013290	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
996285013291	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
996285013292	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
996285013293	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
996285013294	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
996285013295	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
996285013296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285013297	active site
996285013298	phosphorylation site [posttranslational modification]
996285013299	intermolecular recognition site; other site
996285013300	dimerization interface [polypeptide binding]; other site
996285013301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
996285013302	Walker A motif; other site
996285013303	ATP binding site [chemical binding]; other site
996285013304	Walker B motif; other site
996285013305	arginine finger; other site
996285013306	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
996285013307	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285013308	dimerization interface [polypeptide binding]; other site
996285013309	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
996285013310	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013311	putative active site [active]
996285013312	heme pocket [chemical binding]; other site
996285013313	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285013314	dimer interface [polypeptide binding]; other site
996285013315	phosphorylation site [posttranslational modification]
996285013316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285013317	ATP binding site [chemical binding]; other site
996285013318	Mg2+ binding site [ion binding]; other site
996285013319	G-X-G motif; other site
996285013320	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
996285013321	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
996285013322	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
996285013323	amidase catalytic site [active]
996285013324	Zn binding residues [ion binding]; other site
996285013325	substrate binding site [chemical binding]; other site
996285013326	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
996285013327	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
996285013328	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
996285013329	metal binding site [ion binding]; metal-binding site
996285013330	active site
996285013331	I-site; other site
996285013332	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
996285013333	putative catalytic site [active]
996285013334	putative phosphate binding site [ion binding]; other site
996285013335	putative metal binding site [ion binding]; other site
996285013336	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
996285013337	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
996285013338	catalytic residues [active]
996285013339	hinge region; other site
996285013340	alpha helical domain; other site
996285013341	Cytochrome c553 [Energy production and conversion]; Region: COG2863
996285013342	Cytochrome c; Region: Cytochrom_C; cl11414
996285013343	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
996285013344	G1 box; other site
996285013345	GTP/Mg2+ binding site [chemical binding]; other site
996285013346	Switch I region; other site
996285013347	G2 box; other site
996285013348	G3 box; other site
996285013349	Switch II region; other site
996285013350	G4 box; other site
996285013351	G5 box; other site
996285013352	glycine dehydrogenase; Provisional; Region: PRK12566
996285013353	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
996285013354	tetramer interface [polypeptide binding]; other site
996285013355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285013356	catalytic residue [active]
996285013357	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
996285013358	tetramer interface [polypeptide binding]; other site
996285013359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
996285013360	catalytic residue [active]
996285013361	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
996285013362	lipoyl attachment site [posttranslational modification]; other site
996285013363	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
996285013364	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
996285013365	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
996285013366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285013367	dimer interface [polypeptide binding]; other site
996285013368	conserved gate region; other site
996285013369	putative PBP binding loops; other site
996285013370	ABC-ATPase subunit interface; other site
996285013371	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
996285013372	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
996285013373	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
996285013374	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
996285013375	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
996285013376	active site 2 [active]
996285013377	active site 1 [active]
996285013378	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
996285013379	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
996285013380	proline aminopeptidase P II; Provisional; Region: PRK10879
996285013381	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
996285013382	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
996285013383	active site
996285013384	hypothetical protein; Reviewed; Region: PRK02166
996285013385	TIGR02449 family protein; Region: TIGR02449
996285013386	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
996285013387	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
996285013388	Uncharacterized conserved protein [Function unknown]; Region: COG2947
996285013389	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
996285013390	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
996285013391	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
996285013392	NAD(P) binding site [chemical binding]; other site
996285013393	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
996285013394	SecA binding site; other site
996285013395	Preprotein binding site; other site
996285013396	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
996285013397	GSH binding site [chemical binding]; other site
996285013398	catalytic residues [active]
996285013399	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
996285013400	active site residue [active]
996285013401	phosphoglyceromutase; Provisional; Region: PRK05434
996285013402	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
996285013403	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
996285013404	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
996285013405	Peptidase family M23; Region: Peptidase_M23; pfam01551
996285013406	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
996285013407	C-terminal peptidase (prc); Region: prc; TIGR00225
996285013408	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
996285013409	protein binding site [polypeptide binding]; other site
996285013410	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
996285013411	Catalytic dyad [active]
996285013412	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
996285013413	NodB motif; other site
996285013414	putative active site [active]
996285013415	putative catalytic site [active]
996285013416	Zn binding site [ion binding]; other site
996285013417	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
996285013418	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285013419	substrate binding pocket [chemical binding]; other site
996285013420	membrane-bound complex binding site; other site
996285013421	hinge residues; other site
996285013422	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
996285013423	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285013424	substrate binding pocket [chemical binding]; other site
996285013425	membrane-bound complex binding site; other site
996285013426	hinge residues; other site
996285013427	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
996285013428	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
996285013429	substrate binding site [chemical binding]; other site
996285013430	glutamase interaction surface [polypeptide binding]; other site
996285013431	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
996285013432	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
996285013433	catalytic residues [active]
996285013434	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
996285013435	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
996285013436	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
996285013437	putative active site [active]
996285013438	oxyanion strand; other site
996285013439	catalytic triad [active]
996285013440	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
996285013441	putative active site pocket [active]
996285013442	4-fold oligomerization interface [polypeptide binding]; other site
996285013443	metal binding residues [ion binding]; metal-binding site
996285013444	3-fold/trimer interface [polypeptide binding]; other site
996285013445	Nitrate and nitrite sensing; Region: NIT; pfam08376
996285013446	ANTAR domain; Region: ANTAR; pfam03861
996285013447	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
996285013448	NMT1-like family; Region: NMT1_2; pfam13379
996285013449	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
996285013450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285013451	dimer interface [polypeptide binding]; other site
996285013452	conserved gate region; other site
996285013453	putative PBP binding loops; other site
996285013454	ABC-ATPase subunit interface; other site
996285013455	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
996285013456	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
996285013457	Walker A/P-loop; other site
996285013458	ATP binding site [chemical binding]; other site
996285013459	Q-loop/lid; other site
996285013460	ABC transporter signature motif; other site
996285013461	Walker B; other site
996285013462	D-loop; other site
996285013463	H-loop/switch region; other site
996285013464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
996285013465	Coenzyme A binding pocket [chemical binding]; other site
996285013466	AsmA family; Region: AsmA; pfam05170
996285013467	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
996285013468	adenine DNA glycosylase; Provisional; Region: PRK10880
996285013469	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
996285013470	minor groove reading motif; other site
996285013471	helix-hairpin-helix signature motif; other site
996285013472	substrate binding pocket [chemical binding]; other site
996285013473	active site
996285013474	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
996285013475	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
996285013476	DNA binding and oxoG recognition site [nucleotide binding]
996285013477	oxidative damage protection protein; Provisional; Region: PRK05408
996285013478	Staphylococcal nuclease homologues; Region: SNc; smart00318
996285013479	Catalytic site; other site
996285013480	Staphylococcal nuclease homologue; Region: SNase; pfam00565
996285013481	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285013482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285013483	substrate binding pocket [chemical binding]; other site
996285013484	membrane-bound complex binding site; other site
996285013485	hinge residues; other site
996285013486	BCCT family transporter; Region: BCCT; pfam02028
996285013487	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
996285013488	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
996285013489	Walker A/P-loop; other site
996285013490	ATP binding site [chemical binding]; other site
996285013491	Q-loop/lid; other site
996285013492	ABC transporter signature motif; other site
996285013493	Walker B; other site
996285013494	D-loop; other site
996285013495	H-loop/switch region; other site
996285013496	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
996285013497	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
996285013498	substrate binding pocket [chemical binding]; other site
996285013499	membrane-bound complex binding site; other site
996285013500	hinge residues; other site
996285013501	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996285013502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285013503	dimer interface [polypeptide binding]; other site
996285013504	conserved gate region; other site
996285013505	putative PBP binding loops; other site
996285013506	ABC-ATPase subunit interface; other site
996285013507	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
996285013508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
996285013509	dimer interface [polypeptide binding]; other site
996285013510	conserved gate region; other site
996285013511	putative PBP binding loops; other site
996285013512	ABC-ATPase subunit interface; other site
996285013513	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
996285013514	active site
996285013515	phosphate binding residues; other site
996285013516	catalytic residues [active]
996285013517	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285013518	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285013519	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
996285013520	putative dimerization interface [polypeptide binding]; other site
996285013521	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
996285013522	hydroxyglutarate oxidase; Provisional; Region: PRK11728
996285013523	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
996285013524	dimerization interface [polypeptide binding]; other site
996285013525	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
996285013526	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
996285013527	dimer interface [polypeptide binding]; other site
996285013528	putative CheW interface [polypeptide binding]; other site
996285013529	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
996285013530	Malonate transporter MadL subunit; Region: MadL; cl04273
996285013531	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
996285013532	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
996285013533	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
996285013534	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
996285013535	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
996285013536	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
996285013537	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
996285013538	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
996285013539	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
996285013540	Coenzyme A transferase; Region: CoA_trans; cl17247
996285013541	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
996285013542	malonic semialdehyde reductase; Provisional; Region: PRK10538
996285013543	putative NAD(P) binding site [chemical binding]; other site
996285013544	homotetramer interface [polypeptide binding]; other site
996285013545	homodimer interface [polypeptide binding]; other site
996285013546	active site
996285013547	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
996285013548	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
996285013549	active site
996285013550	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
996285013551	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
996285013552	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
996285013553	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
996285013554	DctM-like transporters; Region: DctM; pfam06808
996285013555	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
996285013556	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
996285013557	Transposase; Region: DDE_Tnp_ISL3; pfam01610
996285013558	Ferritin-like domain; Region: Ferritin; pfam00210
996285013559	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
996285013560	dinuclear metal binding motif [ion binding]; other site
996285013561	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
996285013562	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
996285013563	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
996285013564	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
996285013565	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
996285013566	Dodecin; Region: Dodecin; pfam07311
996285013567	putative S-transferase; Provisional; Region: PRK11752
996285013568	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
996285013569	C-terminal domain interface [polypeptide binding]; other site
996285013570	GSH binding site (G-site) [chemical binding]; other site
996285013571	dimer interface [polypeptide binding]; other site
996285013572	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
996285013573	dimer interface [polypeptide binding]; other site
996285013574	N-terminal domain interface [polypeptide binding]; other site
996285013575	active site
996285013576	Predicted membrane protein [Function unknown]; Region: COG3918
996285013577	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
996285013578	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
996285013579	putative active site [active]
996285013580	putative metal binding site [ion binding]; other site
996285013581	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
996285013582	Predicted acetyltransferase [General function prediction only]; Region: COG2388
996285013583	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
996285013584	catalytic triad [active]
996285013585	active site nucleophile [active]
996285013586	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
996285013587	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
996285013588	Walker A/P-loop; other site
996285013589	ATP binding site [chemical binding]; other site
996285013590	Q-loop/lid; other site
996285013591	ABC transporter signature motif; other site
996285013592	Walker B; other site
996285013593	D-loop; other site
996285013594	H-loop/switch region; other site
996285013595	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
996285013596	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
996285013597	active site
996285013598	nucleophile elbow; other site
996285013599	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
996285013600	Protein of unknown function (DUF421); Region: DUF421; pfam04239
996285013601	Transcriptional regulator [Transcription]; Region: LysR; COG0583
996285013602	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
996285013603	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
996285013604	dimerization interface [polypeptide binding]; other site
996285013605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
996285013606	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
996285013607	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
996285013608	phosphoglucomutase; Validated; Region: PRK07564
996285013609	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
996285013610	active site
996285013611	substrate binding site [chemical binding]; other site
996285013612	metal binding site [ion binding]; metal-binding site
996285013613	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
996285013614	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
996285013615	putative NAD(P) binding site [chemical binding]; other site
996285013616	putative substrate binding site [chemical binding]; other site
996285013617	catalytic Zn binding site [ion binding]; other site
996285013618	structural Zn binding site [ion binding]; other site
996285013619	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
996285013620	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
996285013621	putative metal binding site [ion binding]; other site
996285013622	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
996285013623	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
996285013624	trimer interface [polypeptide binding]; other site
996285013625	putative metal binding site [ion binding]; other site
996285013626	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
996285013627	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
996285013628	active site
996285013629	Zn binding site [ion binding]; other site
996285013630	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
996285013631	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
996285013632	Protein of unknown function; Region: DUF3658; pfam12395
996285013633	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
996285013634	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
996285013635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
996285013636	FeS/SAM binding site; other site
996285013637	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
996285013638	active site clefts [active]
996285013639	zinc binding site [ion binding]; other site
996285013640	dimer interface [polypeptide binding]; other site
996285013641	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
996285013642	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
996285013643	Sulfate transporter family; Region: Sulfate_transp; pfam00916
996285013644	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
996285013645	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
996285013646	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
996285013647	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
996285013648	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
996285013649	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
996285013650	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
996285013651	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
996285013652	Subunit I/III interface [polypeptide binding]; other site
996285013653	D-pathway; other site
996285013654	Subunit I/VIIc interface [polypeptide binding]; other site
996285013655	Subunit I/IV interface [polypeptide binding]; other site
996285013656	Subunit I/II interface [polypeptide binding]; other site
996285013657	Low-spin heme (heme a) binding site [chemical binding]; other site
996285013658	Subunit I/VIIa interface [polypeptide binding]; other site
996285013659	Subunit I/VIa interface [polypeptide binding]; other site
996285013660	Dimer interface; other site
996285013661	Putative water exit pathway; other site
996285013662	Binuclear center (heme a3/CuB) [ion binding]; other site
996285013663	K-pathway; other site
996285013664	Subunit I/Vb interface [polypeptide binding]; other site
996285013665	Putative proton exit pathway; other site
996285013666	Subunit I/VIb interface; other site
996285013667	Subunit I/VIc interface [polypeptide binding]; other site
996285013668	Electron transfer pathway; other site
996285013669	Subunit I/VIIIb interface [polypeptide binding]; other site
996285013670	Subunit I/VIIb interface [polypeptide binding]; other site
996285013671	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
996285013672	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
996285013673	Subunit III/VIIa interface [polypeptide binding]; other site
996285013674	Phospholipid binding site [chemical binding]; other site
996285013675	Subunit I/III interface [polypeptide binding]; other site
996285013676	Subunit III/VIb interface [polypeptide binding]; other site
996285013677	Subunit III/VIa interface; other site
996285013678	Subunit III/Vb interface [polypeptide binding]; other site
996285013679	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
996285013680	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
996285013681	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
996285013682	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
996285013683	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
996285013684	UbiA prenyltransferase family; Region: UbiA; pfam01040
996285013685	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
996285013686	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
996285013687	Cu(I) binding site [ion binding]; other site
996285013688	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
996285013689	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
996285013690	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
996285013691	Secretin and TonB N terminus short domain; Region: STN; smart00965
996285013692	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
996285013693	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
996285013694	N-terminal plug; other site
996285013695	ligand-binding site [chemical binding]; other site
996285013696	fec operon regulator FecR; Reviewed; Region: PRK09774
996285013697	FecR protein; Region: FecR; pfam04773
996285013698	RNA polymerase sigma factor; Provisional; Region: PRK12528
996285013699	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
996285013700	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
996285013701	DNA binding residues [nucleotide binding]
996285013702	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
996285013703	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
996285013704	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
996285013705	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
996285013706	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
996285013707	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
996285013708	potential frameshift: common BLAST hit: gi|146284493|ref|YP_001174646.1| phytochrome family protein
996285013709	PAS fold; Region: PAS_2; pfam08446
996285013710	GAF domain; Region: GAF; pfam01590
996285013711	Phytochrome region; Region: PHY; pfam00360
996285013712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285013713	dimer interface [polypeptide binding]; other site
996285013714	phosphorylation site [posttranslational modification]
996285013715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285013716	ATP binding site [chemical binding]; other site
996285013717	Mg2+ binding site [ion binding]; other site
996285013718	G-X-G motif; other site
996285013719	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285013720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285013721	active site
996285013722	phosphorylation site [posttranslational modification]
996285013723	intermolecular recognition site; other site
996285013724	dimerization interface [polypeptide binding]; other site
996285013725	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
996285013726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285013727	active site
996285013728	phosphorylation site [posttranslational modification]
996285013729	intermolecular recognition site; other site
996285013730	dimerization interface [polypeptide binding]; other site
996285013731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013732	PAS fold; Region: PAS_3; pfam08447
996285013733	putative active site [active]
996285013734	heme pocket [chemical binding]; other site
996285013735	PAS domain S-box; Region: sensory_box; TIGR00229
996285013736	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
996285013737	putative active site [active]
996285013738	heme pocket [chemical binding]; other site
996285013739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
996285013740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
996285013741	dimer interface [polypeptide binding]; other site
996285013742	phosphorylation site [posttranslational modification]
996285013743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
996285013744	ATP binding site [chemical binding]; other site
996285013745	Mg2+ binding site [ion binding]; other site
996285013746	G-X-G motif; other site
996285013747	Response regulator receiver domain; Region: Response_reg; pfam00072
996285013748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
996285013749	active site
996285013750	phosphorylation site [posttranslational modification]
996285013751	intermolecular recognition site; other site
996285013752	dimerization interface [polypeptide binding]; other site
996285013753	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
996285013754	heme ligand [chemical binding]; other site
996285013755	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
996285013756	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
996285013757	glutaminase active site [active]
996285013758	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
996285013759	dimer interface [polypeptide binding]; other site
996285013760	active site
996285013761	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
996285013762	dimer interface [polypeptide binding]; other site
996285013763	active site
996285013764	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
996285013765	putative DNA binding site [nucleotide binding]; other site
996285013766	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
996285013767	putative Zn2+ binding site [ion binding]; other site
996285013768	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
996285013769	LysE type translocator; Region: LysE; cl00565
996285013770	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
996285013771	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
996285013772	Substrate binding site; other site
996285013773	Mg++ binding site; other site
996285013774	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
996285013775	active site
996285013776	substrate binding site [chemical binding]; other site
996285013777	CoA binding site [chemical binding]; other site
996285013778	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
996285013779	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
996285013780	gamma subunit interface [polypeptide binding]; other site
996285013781	epsilon subunit interface [polypeptide binding]; other site
996285013782	LBP interface [polypeptide binding]; other site
996285013783	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
996285013784	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
996285013785	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
996285013786	alpha subunit interaction interface [polypeptide binding]; other site
996285013787	Walker A motif; other site
996285013788	ATP binding site [chemical binding]; other site
996285013789	Walker B motif; other site
996285013790	inhibitor binding site; inhibition site
996285013791	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
996285013792	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
996285013793	core domain interface [polypeptide binding]; other site
996285013794	delta subunit interface [polypeptide binding]; other site
996285013795	epsilon subunit interface [polypeptide binding]; other site
996285013796	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
996285013797	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
996285013798	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
996285013799	beta subunit interaction interface [polypeptide binding]; other site
996285013800	Walker A motif; other site
996285013801	ATP binding site [chemical binding]; other site
996285013802	Walker B motif; other site
996285013803	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
996285013804	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
996285013805	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
996285013806	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
996285013807	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
996285013808	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
996285013809	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
996285013810	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
996285013811	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
996285013812	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
996285013813	ParB-like nuclease domain; Region: ParBc; pfam02195
996285013814	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
996285013815	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285013816	P-loop; other site
996285013817	Magnesium ion binding site [ion binding]; other site
996285013818	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
996285013819	Magnesium ion binding site [ion binding]; other site
996285013820	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
996285013821	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
996285013822	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
996285013823	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
996285013824	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
996285013825	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
996285013826	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
996285013827	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
996285013828	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996285013829	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
996285013830	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996285013831	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
996285013832	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
996285013833	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
996285013834	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
996285013835	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
996285013836	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
996285013837	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
996285013838	trmE is a tRNA modification GTPase; Region: trmE; cd04164
996285013839	G1 box; other site
996285013840	GTP/Mg2+ binding site [chemical binding]; other site
996285013841	Switch I region; other site
996285013842	G2 box; other site
996285013843	Switch II region; other site
996285013844	G3 box; other site
996285013845	G4 box; other site
996285013846	G5 box; other site
996285013847	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
996285013848	membrane protein insertase; Provisional; Region: PRK01318
996285013849	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
996285013850	Haemolytic domain; Region: Haemolytic; cl00506
996285013851	Ribonuclease P; Region: Ribonuclease_P; cl00457
996285013852	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399