-- dump date   	20140620_005300
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
205922000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
205922000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922000003	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205922000004	Walker A motif; other site
205922000005	ATP binding site [chemical binding]; other site
205922000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
205922000007	Walker B motif; other site
205922000008	arginine finger; other site
205922000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
205922000010	DnaA box-binding interface [nucleotide binding]; other site
205922000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
205922000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
205922000013	putative DNA binding surface [nucleotide binding]; other site
205922000014	dimer interface [polypeptide binding]; other site
205922000015	beta-clamp/clamp loader binding surface; other site
205922000016	beta-clamp/translesion DNA polymerase binding surface; other site
205922000017	recombination protein F; Reviewed; Region: recF; PRK00064
205922000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922000019	Walker A/P-loop; other site
205922000020	ATP binding site [chemical binding]; other site
205922000021	Q-loop/lid; other site
205922000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922000023	ABC transporter signature motif; other site
205922000024	Walker B; other site
205922000025	D-loop; other site
205922000026	H-loop/switch region; other site
205922000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
205922000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922000029	Mg2+ binding site [ion binding]; other site
205922000030	G-X-G motif; other site
205922000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
205922000032	anchoring element; other site
205922000033	dimer interface [polypeptide binding]; other site
205922000034	ATP binding site [chemical binding]; other site
205922000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
205922000036	active site
205922000037	putative metal-binding site [ion binding]; other site
205922000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
205922000039	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922000040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922000041	active site
205922000042	phosphorylation site [posttranslational modification]
205922000043	intermolecular recognition site; other site
205922000044	dimerization interface [polypeptide binding]; other site
205922000045	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922000046	DNA binding site [nucleotide binding]
205922000047	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205922000048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922000049	dimer interface [polypeptide binding]; other site
205922000050	phosphorylation site [posttranslational modification]
205922000051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922000052	ATP binding site [chemical binding]; other site
205922000053	Mg2+ binding site [ion binding]; other site
205922000054	G-X-G motif; other site
205922000055	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922000056	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
205922000057	putative acyl-acceptor binding pocket; other site
205922000058	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
205922000059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922000060	active site
205922000061	motif I; other site
205922000062	motif II; other site
205922000063	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
205922000064	HD domain; Region: HD; pfam01966
205922000065	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
205922000066	dimer interface [polypeptide binding]; other site
205922000067	motif 1; other site
205922000068	active site
205922000069	motif 2; other site
205922000070	motif 3; other site
205922000071	DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624
205922000072	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
205922000073	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
205922000074	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
205922000075	putative acyl-acceptor binding pocket; other site
205922000076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922000077	TPR motif; other site
205922000078	TPR repeat; Region: TPR_11; pfam13414
205922000079	binding surface
205922000080	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
205922000081	TrkA-N domain; Region: TrkA_N; pfam02254
205922000082	TrkA-C domain; Region: TrkA_C; pfam02080
205922000083	TrkA-N domain; Region: TrkA_N; pfam02254
205922000084	TrkA-C domain; Region: TrkA_C; pfam02080
205922000085	16S rRNA methyltransferase B; Provisional; Region: PRK10901
205922000086	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
205922000087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922000088	S-adenosylmethionine binding site [chemical binding]; other site
205922000089	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
205922000090	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
205922000091	putative active site [active]
205922000092	substrate binding site [chemical binding]; other site
205922000093	putative cosubstrate binding site; other site
205922000094	catalytic site [active]
205922000095	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
205922000096	substrate binding site [chemical binding]; other site
205922000097	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
205922000098	active site
205922000099	catalytic residues [active]
205922000100	metal binding site [ion binding]; metal-binding site
205922000101	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
205922000102	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922000103	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
205922000104	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
205922000105	DNA protecting protein DprA; Region: dprA; TIGR00732
205922000106	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
205922000107	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
205922000108	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
205922000109	NADP binding site [chemical binding]; other site
205922000110	dimer interface [polypeptide binding]; other site
205922000111	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
205922000112	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
205922000113	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
205922000114	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
205922000115	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
205922000116	shikimate binding site; other site
205922000117	NAD(P) binding site [chemical binding]; other site
205922000118	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
205922000119	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
205922000120	Sulfate transporter family; Region: Sulfate_transp; pfam00916
205922000121	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
205922000122	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
205922000123	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922000124	Sulfatase; Region: Sulfatase; cl17466
205922000125	choline-sulfatase; Region: chol_sulfatase; TIGR03417
205922000126	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
205922000127	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
205922000128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000129	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
205922000130	dimerization interface [polypeptide binding]; other site
205922000131	substrate binding pocket [chemical binding]; other site
205922000132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922000133	NADH(P)-binding; Region: NAD_binding_10; pfam13460
205922000134	NAD(P) binding site [chemical binding]; other site
205922000135	active site
205922000136	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
205922000137	Uncharacterized conserved protein [Function unknown]; Region: COG3791
205922000138	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
205922000139	Citrate transporter; Region: CitMHS; pfam03600
205922000140	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
205922000141	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205922000142	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205922000143	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205922000144	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
205922000145	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
205922000146	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
205922000147	PhoU domain; Region: PhoU; pfam01895
205922000148	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
205922000149	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
205922000150	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205922000151	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
205922000152	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
205922000153	Permease; Region: Permease; pfam02405
205922000154	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
205922000155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922000156	Walker A/P-loop; other site
205922000157	ATP binding site [chemical binding]; other site
205922000158	Q-loop/lid; other site
205922000159	ABC transporter signature motif; other site
205922000160	Walker B; other site
205922000161	D-loop; other site
205922000162	H-loop/switch region; other site
205922000163	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
205922000164	mce related protein; Region: MCE; pfam02470
205922000165	Protein of unknown function (DUF330); Region: DUF330; cl01135
205922000166	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
205922000167	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
205922000168	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
205922000169	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922000170	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
205922000171	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922000172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922000173	active site
205922000174	phosphorylation site [posttranslational modification]
205922000175	intermolecular recognition site; other site
205922000176	dimerization interface [polypeptide binding]; other site
205922000177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922000178	Walker A motif; other site
205922000179	ATP binding site [chemical binding]; other site
205922000180	Walker B motif; other site
205922000181	arginine finger; other site
205922000182	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922000183	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922000184	dimerization interface [polypeptide binding]; other site
205922000185	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205922000186	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922000187	putative active site [active]
205922000188	heme pocket [chemical binding]; other site
205922000189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922000190	dimer interface [polypeptide binding]; other site
205922000191	phosphorylation site [posttranslational modification]
205922000192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922000193	ATP binding site [chemical binding]; other site
205922000194	Mg2+ binding site [ion binding]; other site
205922000195	G-X-G motif; other site
205922000196	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
205922000197	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
205922000198	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922000199	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
205922000200	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
205922000201	amidase catalytic site [active]
205922000202	Zn binding residues [ion binding]; other site
205922000203	substrate binding site [chemical binding]; other site
205922000204	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
205922000205	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922000206	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922000207	metal binding site [ion binding]; metal-binding site
205922000208	active site
205922000209	I-site; other site
205922000210	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
205922000211	putative catalytic site [active]
205922000212	putative metal binding site [ion binding]; other site
205922000213	putative phosphate binding site [ion binding]; other site
205922000214	putative catalytic site [active]
205922000215	putative phosphate binding site [ion binding]; other site
205922000216	putative metal binding site [ion binding]; other site
205922000217	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
205922000218	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
205922000219	catalytic residues [active]
205922000220	hinge region; other site
205922000221	alpha helical domain; other site
205922000222	Cytochrome c553 [Energy production and conversion]; Region: COG2863
205922000223	Cytochrome c; Region: Cytochrom_C; cl11414
205922000224	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
205922000225	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
205922000226	G1 box; other site
205922000227	GTP/Mg2+ binding site [chemical binding]; other site
205922000228	Switch I region; other site
205922000229	G2 box; other site
205922000230	G3 box; other site
205922000231	Switch II region; other site
205922000232	G4 box; other site
205922000233	G5 box; other site
205922000234	DNA polymerase I; Provisional; Region: PRK05755
205922000235	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
205922000236	active site
205922000237	metal binding site 1 [ion binding]; metal-binding site
205922000238	putative 5' ssDNA interaction site; other site
205922000239	metal binding site 3; metal-binding site
205922000240	metal binding site 2 [ion binding]; metal-binding site
205922000241	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
205922000242	putative DNA binding site [nucleotide binding]; other site
205922000243	putative metal binding site [ion binding]; other site
205922000244	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
205922000245	active site
205922000246	catalytic site [active]
205922000247	substrate binding site [chemical binding]; other site
205922000248	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
205922000249	active site
205922000250	DNA binding site [nucleotide binding]
205922000251	catalytic site [active]
205922000252	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
205922000253	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
205922000254	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
205922000255	putative active site [active]
205922000256	putative substrate binding site [chemical binding]; other site
205922000257	ATP binding site [chemical binding]; other site
205922000258	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
205922000259	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
205922000260	metal binding site [ion binding]; metal-binding site
205922000261	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
205922000262	metal binding site 2 [ion binding]; metal-binding site
205922000263	putative DNA binding helix; other site
205922000264	metal binding site 1 [ion binding]; metal-binding site
205922000265	dimer interface [polypeptide binding]; other site
205922000266	structural Zn2+ binding site [ion binding]; other site
205922000267	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
205922000268	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
205922000269	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
205922000270	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205922000271	dimer interface [polypeptide binding]; other site
205922000272	putative PBP binding regions; other site
205922000273	ABC-ATPase subunit  interface; other site
205922000274	hydroperoxidase II; Provisional; Region: katE; PRK11249
205922000275	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
205922000276	tetramer interface [polypeptide binding]; other site
205922000277	heme binding pocket [chemical binding]; other site
205922000278	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
205922000279	domain interactions; other site
205922000280	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
205922000281	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
205922000282	Walker A/P-loop; other site
205922000283	ATP binding site [chemical binding]; other site
205922000284	Q-loop/lid; other site
205922000285	ABC transporter signature motif; other site
205922000286	Walker B; other site
205922000287	D-loop; other site
205922000288	H-loop/switch region; other site
205922000289	NIL domain; Region: NIL; pfam09383
205922000290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000291	dimer interface [polypeptide binding]; other site
205922000292	conserved gate region; other site
205922000293	ABC-ATPase subunit interface; other site
205922000294	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
205922000295	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
205922000296	putative transposase OrfB; Reviewed; Region: PHA02517
205922000297	Integrase core domain; Region: rve; pfam00665
205922000298	Integrase core domain; Region: rve_3; pfam13683
205922000299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
205922000300	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
205922000301	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205922000302	Cu(I) binding site [ion binding]; other site
205922000303	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
205922000304	UbiA prenyltransferase family; Region: UbiA; pfam01040
205922000305	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
205922000306	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
205922000307	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
205922000308	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
205922000309	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
205922000310	Subunit III/VIIa interface [polypeptide binding]; other site
205922000311	Phospholipid binding site [chemical binding]; other site
205922000312	Subunit I/III interface [polypeptide binding]; other site
205922000313	Subunit III/VIb interface [polypeptide binding]; other site
205922000314	Subunit III/VIa interface; other site
205922000315	Subunit III/Vb interface [polypeptide binding]; other site
205922000316	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
205922000317	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
205922000318	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
205922000319	Subunit I/III interface [polypeptide binding]; other site
205922000320	D-pathway; other site
205922000321	Subunit I/VIIc interface [polypeptide binding]; other site
205922000322	Subunit I/IV interface [polypeptide binding]; other site
205922000323	Subunit I/II interface [polypeptide binding]; other site
205922000324	Low-spin heme (heme a) binding site [chemical binding]; other site
205922000325	Subunit I/VIIa interface [polypeptide binding]; other site
205922000326	Subunit I/VIa interface [polypeptide binding]; other site
205922000327	Dimer interface; other site
205922000328	Putative water exit pathway; other site
205922000329	Binuclear center (heme a3/CuB) [ion binding]; other site
205922000330	K-pathway; other site
205922000331	Subunit I/Vb interface [polypeptide binding]; other site
205922000332	Putative proton exit pathway; other site
205922000333	Subunit I/VIb interface; other site
205922000334	Subunit I/VIc interface [polypeptide binding]; other site
205922000335	Electron transfer pathway; other site
205922000336	Subunit I/VIIIb interface [polypeptide binding]; other site
205922000337	Subunit I/VIIb interface [polypeptide binding]; other site
205922000338	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
205922000339	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
205922000340	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
205922000341	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922000342	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922000343	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
205922000344	Sulfate transporter family; Region: Sulfate_transp; pfam00916
205922000345	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
205922000346	active site clefts [active]
205922000347	zinc binding site [ion binding]; other site
205922000348	dimer interface [polypeptide binding]; other site
205922000349	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
205922000350	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922000351	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922000352	Cytochrome c; Region: Cytochrom_C; pfam00034
205922000353	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
205922000354	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922000355	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
205922000356	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
205922000357	active site
205922000358	catalytic residues [active]
205922000359	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
205922000360	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
205922000361	Zn binding site [ion binding]; other site
205922000362	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
205922000363	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
205922000364	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
205922000365	active site
205922000366	Zn binding site [ion binding]; other site
205922000367	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
205922000368	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
205922000369	trimer interface [polypeptide binding]; other site
205922000370	putative metal binding site [ion binding]; other site
205922000371	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
205922000372	Eukaryotic phosphomannomutase; Region: PMM; cl17107
205922000373	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922000374	motif II; other site
205922000375	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
205922000376	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
205922000377	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
205922000378	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
205922000379	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
205922000380	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
205922000381	Dodecin; Region: Dodecin; pfam07311
205922000382	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
205922000383	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922000384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000385	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922000386	dimerization interface [polypeptide binding]; other site
205922000387	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
205922000388	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
205922000389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922000390	catalytic residue [active]
205922000391	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
205922000392	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
205922000393	substrate binding site [chemical binding]; other site
205922000394	active site
205922000395	catalytic residues [active]
205922000396	heterodimer interface [polypeptide binding]; other site
205922000397	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
205922000398	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
205922000399	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
205922000400	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
205922000401	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
205922000402	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
205922000403	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
205922000404	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
205922000405	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
205922000406	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
205922000407	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
205922000408	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
205922000409	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
205922000410	ligand binding site [chemical binding]; other site
205922000411	homodimer interface [polypeptide binding]; other site
205922000412	NAD(P) binding site [chemical binding]; other site
205922000413	trimer interface B [polypeptide binding]; other site
205922000414	trimer interface A [polypeptide binding]; other site
205922000415	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922000416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000417	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
205922000418	dimerization interface [polypeptide binding]; other site
205922000419	substrate binding pocket [chemical binding]; other site
205922000420	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
205922000421	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922000422	FAD binding site [chemical binding]; other site
205922000423	substrate binding pocket [chemical binding]; other site
205922000424	catalytic base [active]
205922000425	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
205922000426	CoA-transferase family III; Region: CoA_transf_3; pfam02515
205922000427	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
205922000428	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
205922000429	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
205922000430	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922000431	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
205922000432	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922000433	N-terminal plug; other site
205922000434	ligand-binding site [chemical binding]; other site
205922000435	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922000436	FecR protein; Region: FecR; pfam04773
205922000437	RNA polymerase sigma factor; Provisional; Region: PRK12528
205922000438	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922000439	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922000440	DNA binding residues [nucleotide binding]
205922000441	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
205922000442	Cache domain; Region: Cache_1; pfam02743
205922000443	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922000444	dimerization interface [polypeptide binding]; other site
205922000445	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922000446	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922000447	dimer interface [polypeptide binding]; other site
205922000448	putative CheW interface [polypeptide binding]; other site
205922000449	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
205922000450	putative hydrophobic ligand binding site [chemical binding]; other site
205922000451	protein interface [polypeptide binding]; other site
205922000452	gate; other site
205922000453	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922000454	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922000455	AMP binding site [chemical binding]; other site
205922000456	acyl-activating enzyme (AAE) consensus motif; other site
205922000457	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922000458	thioester reductase domain; Region: Thioester-redct; TIGR01746
205922000459	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
205922000460	putative NAD(P) binding site [chemical binding]; other site
205922000461	active site
205922000462	putative substrate binding site [chemical binding]; other site
205922000463	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
205922000464	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
205922000465	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
205922000466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922000467	DNA-binding site [nucleotide binding]; DNA binding site
205922000468	FCD domain; Region: FCD; pfam07729
205922000469	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
205922000470	biofilm formation regulator HmsP; Provisional; Region: PRK11829
205922000471	HAMP domain; Region: HAMP; pfam00672
205922000472	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922000473	metal binding site [ion binding]; metal-binding site
205922000474	active site
205922000475	I-site; other site
205922000476	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922000477	Calx-beta domain; Region: Calx-beta; cl02522
205922000478	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
205922000479	metal ion-dependent adhesion site (MIDAS); other site
205922000480	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922000481	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
205922000482	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
205922000483	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
205922000484	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
205922000485	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922000486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922000487	Walker A/P-loop; other site
205922000488	ATP binding site [chemical binding]; other site
205922000489	Q-loop/lid; other site
205922000490	ABC transporter signature motif; other site
205922000491	Walker B; other site
205922000492	D-loop; other site
205922000493	H-loop/switch region; other site
205922000494	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
205922000495	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922000496	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000497	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
205922000498	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
205922000499	active site
205922000500	iron coordination sites [ion binding]; other site
205922000501	substrate binding pocket [chemical binding]; other site
205922000502	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
205922000503	NMT1-like family; Region: NMT1_2; pfam13379
205922000504	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
205922000505	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922000506	Walker A/P-loop; other site
205922000507	ATP binding site [chemical binding]; other site
205922000508	Q-loop/lid; other site
205922000509	ABC transporter signature motif; other site
205922000510	Walker B; other site
205922000511	D-loop; other site
205922000512	H-loop/switch region; other site
205922000513	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922000514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000515	dimer interface [polypeptide binding]; other site
205922000516	conserved gate region; other site
205922000517	putative PBP binding loops; other site
205922000518	ABC-ATPase subunit interface; other site
205922000519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922000520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000521	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
205922000522	putative substrate binding pocket [chemical binding]; other site
205922000523	putative dimerization interface [polypeptide binding]; other site
205922000524	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
205922000525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922000526	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
205922000527	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000528	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922000529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922000530	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000531	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922000532	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000533	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
205922000534	active site
205922000535	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
205922000536	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922000537	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000538	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922000539	Coenzyme A binding pocket [chemical binding]; other site
205922000540	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
205922000541	active site flap/lid [active]
205922000542	nucleophilic elbow; other site
205922000543	catalytic triad [active]
205922000544	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
205922000545	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922000546	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922000547	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922000548	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
205922000549	Phage Tail Collar Domain; Region: Collar; pfam07484
205922000550	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
205922000551	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
205922000552	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
205922000553	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
205922000554	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
205922000555	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
205922000556	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
205922000557	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
205922000558	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
205922000559	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
205922000560	ligand-binding site [chemical binding]; other site
205922000561	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
205922000562	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
205922000563	Predicted permease [General function prediction only]; Region: COG2985
205922000564	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
205922000565	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
205922000566	putative deacylase active site [active]
205922000567	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
205922000568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922000569	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
205922000570	Fusaric acid resistance protein family; Region: FUSC; pfam04632
205922000571	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
205922000572	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
205922000573	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
205922000574	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922000575	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000576	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922000577	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
205922000578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
205922000579	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
205922000580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922000581	binding surface
205922000582	TPR motif; other site
205922000583	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
205922000584	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
205922000585	putative active site [active]
205922000586	putative metal binding site [ion binding]; other site
205922000587	N-glycosyltransferase; Provisional; Region: PRK11204
205922000588	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
205922000589	DXD motif; other site
205922000590	PgaD-like protein; Region: PgaD; pfam13994
205922000591	AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478
205922000592	[2Fe-2S] cluster binding site [ion binding]; other site
205922000593	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
205922000594	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922000595	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
205922000596	substrate binding site [chemical binding]; other site
205922000597	von Willebrand factor; Region: vWF_A; pfam12450
205922000598	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
205922000599	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
205922000600	metal ion-dependent adhesion site (MIDAS); other site
205922000601	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
205922000602	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
205922000603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922000604	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922000605	DNA binding residues [nucleotide binding]
205922000606	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
205922000607	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
205922000608	tetramerization interface [polypeptide binding]; other site
205922000609	NAD(P) binding site [chemical binding]; other site
205922000610	catalytic residues [active]
205922000611	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
205922000612	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922000613	inhibitor-cofactor binding pocket; inhibition site
205922000614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922000615	catalytic residue [active]
205922000616	Response regulator receiver domain; Region: Response_reg; pfam00072
205922000617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922000618	active site
205922000619	phosphorylation site [posttranslational modification]
205922000620	intermolecular recognition site; other site
205922000621	dimerization interface [polypeptide binding]; other site
205922000622	HDOD domain; Region: HDOD; pfam08668
205922000623	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
205922000624	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922000625	PAS fold; Region: PAS_3; pfam08447
205922000626	putative active site [active]
205922000627	heme pocket [chemical binding]; other site
205922000628	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922000629	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922000630	metal binding site [ion binding]; metal-binding site
205922000631	active site
205922000632	I-site; other site
205922000633	Fatty acid desaturase; Region: FA_desaturase; pfam00487
205922000634	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
205922000635	Di-iron ligands [ion binding]; other site
205922000636	Transposase; Region: DDE_Tnp_ISL3; pfam01610
205922000637	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922000638	PAS domain; Region: PAS_9; pfam13426
205922000639	putative active site [active]
205922000640	heme pocket [chemical binding]; other site
205922000641	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922000642	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922000643	metal binding site [ion binding]; metal-binding site
205922000644	active site
205922000645	I-site; other site
205922000646	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922000647	Uncharacterized small protein [Function unknown]; Region: COG5583
205922000648	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
205922000649	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205922000650	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
205922000651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000652	dimer interface [polypeptide binding]; other site
205922000653	conserved gate region; other site
205922000654	putative PBP binding loops; other site
205922000655	ABC-ATPase subunit interface; other site
205922000656	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
205922000657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000658	dimer interface [polypeptide binding]; other site
205922000659	conserved gate region; other site
205922000660	putative PBP binding loops; other site
205922000661	ABC-ATPase subunit interface; other site
205922000662	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
205922000663	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
205922000664	Walker A/P-loop; other site
205922000665	ATP binding site [chemical binding]; other site
205922000666	Q-loop/lid; other site
205922000667	ABC transporter signature motif; other site
205922000668	Walker B; other site
205922000669	D-loop; other site
205922000670	H-loop/switch region; other site
205922000671	TOBE-like domain; Region: TOBE_3; pfam12857
205922000672	Predicted membrane protein [Function unknown]; Region: COG4539
205922000673	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205922000674	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922000675	ligand binding site [chemical binding]; other site
205922000676	flexible hinge region; other site
205922000677	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
205922000678	non-specific DNA interactions [nucleotide binding]; other site
205922000679	DNA binding site [nucleotide binding]
205922000680	sequence specific DNA binding site [nucleotide binding]; other site
205922000681	putative cAMP binding site [chemical binding]; other site
205922000682	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
205922000683	active site
205922000684	homotetramer interface [polypeptide binding]; other site
205922000685	Domain of unknown function (DUF336); Region: DUF336; pfam03928
205922000686	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
205922000687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922000688	active site
205922000689	phosphorylation site [posttranslational modification]
205922000690	intermolecular recognition site; other site
205922000691	dimerization interface [polypeptide binding]; other site
205922000692	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922000693	DNA binding site [nucleotide binding]
205922000694	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
205922000695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922000696	dimer interface [polypeptide binding]; other site
205922000697	phosphorylation site [posttranslational modification]
205922000698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922000699	ATP binding site [chemical binding]; other site
205922000700	Mg2+ binding site [ion binding]; other site
205922000701	G-X-G motif; other site
205922000702	HipA N-terminal domain; Region: Couple_hipA; pfam13657
205922000703	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
205922000704	HipA-like N-terminal domain; Region: HipA_N; pfam07805
205922000705	HipA-like C-terminal domain; Region: HipA_C; pfam07804
205922000706	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922000707	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922000708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922000709	Fatty acid desaturase; Region: FA_desaturase; pfam00487
205922000710	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
205922000711	Sulfatase; Region: Sulfatase; pfam00884
205922000712	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
205922000713	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922000714	Walker A/P-loop; other site
205922000715	ATP binding site [chemical binding]; other site
205922000716	Q-loop/lid; other site
205922000717	ABC transporter signature motif; other site
205922000718	Walker B; other site
205922000719	D-loop; other site
205922000720	H-loop/switch region; other site
205922000721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
205922000722	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922000723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
205922000724	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
205922000725	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
205922000726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922000727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000728	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922000729	dimerization interface [polypeptide binding]; other site
205922000730	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
205922000731	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
205922000732	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
205922000733	Sulfatase; Region: Sulfatase; cl17466
205922000734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922000735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922000737	dimerization interface [polypeptide binding]; other site
205922000738	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
205922000739	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922000740	N-terminal plug; other site
205922000741	ligand-binding site [chemical binding]; other site
205922000742	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
205922000743	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
205922000744	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
205922000745	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
205922000746	TolR protein; Region: tolR; TIGR02801
205922000747	Serine hydrolase; Region: Ser_hydrolase; pfam06821
205922000748	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922000749	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922000750	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205922000751	Walker A motif; other site
205922000752	ATP binding site [chemical binding]; other site
205922000753	Walker B motif; other site
205922000754	arginine finger; other site
205922000755	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
205922000756	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
205922000757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000758	dimer interface [polypeptide binding]; other site
205922000759	conserved gate region; other site
205922000760	putative PBP binding loops; other site
205922000761	ABC-ATPase subunit interface; other site
205922000762	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922000763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000764	dimer interface [polypeptide binding]; other site
205922000765	conserved gate region; other site
205922000766	putative PBP binding loops; other site
205922000767	ABC-ATPase subunit interface; other site
205922000768	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922000769	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922000770	Walker A/P-loop; other site
205922000771	ATP binding site [chemical binding]; other site
205922000772	Q-loop/lid; other site
205922000773	ABC transporter signature motif; other site
205922000774	Walker B; other site
205922000775	D-loop; other site
205922000776	H-loop/switch region; other site
205922000777	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
205922000778	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922000779	substrate binding pocket [chemical binding]; other site
205922000780	membrane-bound complex binding site; other site
205922000781	hinge residues; other site
205922000782	Predicted ATPase [General function prediction only]; Region: COG4637
205922000783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922000784	Walker A/P-loop; other site
205922000785	ATP binding site [chemical binding]; other site
205922000786	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922000787	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922000788	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922000789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922000790	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
205922000791	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922000792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922000793	S-adenosylmethionine binding site [chemical binding]; other site
205922000794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000795	dimer interface [polypeptide binding]; other site
205922000796	conserved gate region; other site
205922000797	ABC-ATPase subunit interface; other site
205922000798	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
205922000799	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
205922000800	Walker A/P-loop; other site
205922000801	ATP binding site [chemical binding]; other site
205922000802	Q-loop/lid; other site
205922000803	ABC transporter signature motif; other site
205922000804	Walker B; other site
205922000805	D-loop; other site
205922000806	H-loop/switch region; other site
205922000807	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
205922000808	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
205922000809	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
205922000810	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
205922000811	active site
205922000812	non-prolyl cis peptide bond; other site
205922000813	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
205922000814	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
205922000815	Flavin binding site [chemical binding]; other site
205922000816	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
205922000817	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
205922000818	Flavin binding site [chemical binding]; other site
205922000819	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
205922000820	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922000821	Walker A/P-loop; other site
205922000822	ATP binding site [chemical binding]; other site
205922000823	Q-loop/lid; other site
205922000824	ABC transporter signature motif; other site
205922000825	Walker B; other site
205922000826	D-loop; other site
205922000827	H-loop/switch region; other site
205922000828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000829	dimer interface [polypeptide binding]; other site
205922000830	conserved gate region; other site
205922000831	putative PBP binding loops; other site
205922000832	ABC-ATPase subunit interface; other site
205922000833	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922000834	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922000835	substrate binding pocket [chemical binding]; other site
205922000836	membrane-bound complex binding site; other site
205922000837	hinge residues; other site
205922000838	D-cysteine desulfhydrase; Validated; Region: PRK03910
205922000839	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
205922000840	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922000841	catalytic residue [active]
205922000842	serine O-acetyltransferase; Region: cysE; TIGR01172
205922000843	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
205922000844	trimer interface [polypeptide binding]; other site
205922000845	active site
205922000846	substrate binding site [chemical binding]; other site
205922000847	CoA binding site [chemical binding]; other site
205922000848	BCCT family transporter; Region: BCCT; cl00569
205922000849	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205922000850	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205922000851	DNA binding site [nucleotide binding]
205922000852	domain linker motif; other site
205922000853	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
205922000854	putative ligand binding site [chemical binding]; other site
205922000855	putative dimerization interface [polypeptide binding]; other site
205922000856	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
205922000857	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922000858	N-terminal plug; other site
205922000859	ligand-binding site [chemical binding]; other site
205922000860	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
205922000861	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
205922000862	active site
205922000863	non-prolyl cis peptide bond; other site
205922000864	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922000865	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922000866	active site
205922000867	catalytic tetrad [active]
205922000868	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
205922000869	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
205922000870	active site
205922000871	iron coordination sites [ion binding]; other site
205922000872	substrate binding pocket [chemical binding]; other site
205922000873	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922000874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922000875	dimer interface [polypeptide binding]; other site
205922000876	conserved gate region; other site
205922000877	putative PBP binding loops; other site
205922000878	ABC-ATPase subunit interface; other site
205922000879	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
205922000880	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922000881	Walker A/P-loop; other site
205922000882	ATP binding site [chemical binding]; other site
205922000883	Q-loop/lid; other site
205922000884	ABC transporter signature motif; other site
205922000885	Walker B; other site
205922000886	D-loop; other site
205922000887	H-loop/switch region; other site
205922000888	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
205922000889	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922000890	substrate binding pocket [chemical binding]; other site
205922000891	membrane-bound complex binding site; other site
205922000892	hinge residues; other site
205922000893	glutamate--cysteine ligase; Provisional; Region: PRK02107
205922000894	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205922000895	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
205922000896	CoenzymeA binding site [chemical binding]; other site
205922000897	subunit interaction site [polypeptide binding]; other site
205922000898	PHB binding site; other site
205922000899	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
205922000900	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
205922000901	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
205922000902	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
205922000903	RNA binding site [nucleotide binding]; other site
205922000904	osmolarity response regulator; Provisional; Region: ompR; PRK09468
205922000905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922000906	active site
205922000907	phosphorylation site [posttranslational modification]
205922000908	intermolecular recognition site; other site
205922000909	dimerization interface [polypeptide binding]; other site
205922000910	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922000911	DNA binding site [nucleotide binding]
205922000912	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
205922000913	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922000914	dimerization interface [polypeptide binding]; other site
205922000915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922000916	ATP binding site [chemical binding]; other site
205922000917	Mg2+ binding site [ion binding]; other site
205922000918	G-X-G motif; other site
205922000919	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
205922000920	RimK-like ATP-grasp domain; Region: RimK; pfam08443
205922000921	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
205922000922	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922000923	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922000924	RNA binding surface [nucleotide binding]; other site
205922000925	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
205922000926	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
205922000927	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
205922000928	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
205922000929	dimerization interface [polypeptide binding]; other site
205922000930	domain crossover interface; other site
205922000931	redox-dependent activation switch; other site
205922000932	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
205922000933	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
205922000934	active site
205922000935	substrate-binding site [chemical binding]; other site
205922000936	metal-binding site [ion binding]
205922000937	ATP binding site [chemical binding]; other site
205922000938	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922000939	non-specific DNA binding site [nucleotide binding]; other site
205922000940	salt bridge; other site
205922000941	sequence-specific DNA binding site [nucleotide binding]; other site
205922000942	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
205922000943	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922000944	ATP binding site [chemical binding]; other site
205922000945	putative Mg++ binding site [ion binding]; other site
205922000946	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922000947	nucleotide binding region [chemical binding]; other site
205922000948	ATP-binding site [chemical binding]; other site
205922000949	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
205922000950	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922000951	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922000952	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922000953	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
205922000954	active site
205922000955	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
205922000956	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
205922000957	putative molybdopterin cofactor binding site [chemical binding]; other site
205922000958	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
205922000959	putative molybdopterin cofactor binding site; other site
205922000960	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
205922000961	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922000962	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922000963	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922000964	dimerization interface [polypeptide binding]; other site
205922000965	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
205922000966	BON domain; Region: BON; pfam04972
205922000967	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922000968	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
205922000969	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922000970	motif II; other site
205922000971	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
205922000972	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
205922000973	dimer interface [polypeptide binding]; other site
205922000974	ADP-ribose binding site [chemical binding]; other site
205922000975	active site
205922000976	nudix motif; other site
205922000977	metal binding site [ion binding]; metal-binding site
205922000978	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
205922000979	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
205922000980	active site
205922000981	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
205922000982	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922000983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922000984	active site
205922000985	phosphorylation site [posttranslational modification]
205922000986	intermolecular recognition site; other site
205922000987	dimerization interface [polypeptide binding]; other site
205922000988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922000989	Walker A motif; other site
205922000990	ATP binding site [chemical binding]; other site
205922000991	Walker B motif; other site
205922000992	arginine finger; other site
205922000993	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922000994	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
205922000995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922000996	dimer interface [polypeptide binding]; other site
205922000997	phosphorylation site [posttranslational modification]
205922000998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922000999	ATP binding site [chemical binding]; other site
205922001000	G-X-G motif; other site
205922001001	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
205922001002	hypothetical protein; Provisional; Region: PRK06149
205922001003	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
205922001004	active site
205922001005	ATP binding site [chemical binding]; other site
205922001006	substrate binding site [chemical binding]; other site
205922001007	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922001008	inhibitor-cofactor binding pocket; inhibition site
205922001009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922001010	catalytic residue [active]
205922001011	agmatine deiminase; Provisional; Region: PRK13551
205922001012	agmatine deiminase; Region: agmatine_aguA; TIGR03380
205922001013	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922001014	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922001015	N-terminal plug; other site
205922001016	ligand-binding site [chemical binding]; other site
205922001017	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
205922001018	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
205922001019	catalytic residues [active]
205922001020	outer membrane porin, OprD family; Region: OprD; pfam03573
205922001021	Biofilm formation and stress response factor; Region: BsmA; pfam10014
205922001022	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922001023	Coenzyme A binding pocket [chemical binding]; other site
205922001024	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
205922001025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922001026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922001027	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922001028	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
205922001029	active site 1 [active]
205922001030	dimer interface [polypeptide binding]; other site
205922001031	hexamer interface [polypeptide binding]; other site
205922001032	active site 2 [active]
205922001033	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
205922001034	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
205922001035	catalytic residues [active]
205922001036	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
205922001037	classical (c) SDRs; Region: SDR_c; cd05233
205922001038	NAD(P) binding site [chemical binding]; other site
205922001039	active site
205922001040	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
205922001041	YcfA-like protein; Region: YcfA; pfam07927
205922001042	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
205922001043	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
205922001044	DNA-binding interface [nucleotide binding]; DNA binding site
205922001045	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922001046	sequence-specific DNA binding site [nucleotide binding]; other site
205922001047	salt bridge; other site
205922001048	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
205922001049	Methyltransferase domain; Region: Methyltransf_32; pfam13679
205922001050	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922001051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922001052	dimer interface [polypeptide binding]; other site
205922001053	conserved gate region; other site
205922001054	putative PBP binding loops; other site
205922001055	ABC-ATPase subunit interface; other site
205922001056	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922001057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922001058	dimer interface [polypeptide binding]; other site
205922001059	conserved gate region; other site
205922001060	putative PBP binding loops; other site
205922001061	ABC-ATPase subunit interface; other site
205922001062	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922001063	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922001064	substrate binding pocket [chemical binding]; other site
205922001065	membrane-bound complex binding site; other site
205922001066	hinge residues; other site
205922001067	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
205922001068	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922001069	Walker A/P-loop; other site
205922001070	ATP binding site [chemical binding]; other site
205922001071	Q-loop/lid; other site
205922001072	ABC transporter signature motif; other site
205922001073	Walker B; other site
205922001074	D-loop; other site
205922001075	H-loop/switch region; other site
205922001076	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
205922001077	Spore germination protein; Region: Spore_permease; cl17796
205922001078	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
205922001079	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922001080	oxidative damage protection protein; Provisional; Region: PRK05408
205922001081	adenine DNA glycosylase; Provisional; Region: PRK10880
205922001082	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
205922001083	minor groove reading motif; other site
205922001084	helix-hairpin-helix signature motif; other site
205922001085	substrate binding pocket [chemical binding]; other site
205922001086	active site
205922001087	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
205922001088	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
205922001089	DNA binding and oxoG recognition site [nucleotide binding]
205922001090	AsmA family; Region: AsmA; pfam05170
205922001091	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
205922001092	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922001093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922001094	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
205922001095	putative active site pocket [active]
205922001096	4-fold oligomerization interface [polypeptide binding]; other site
205922001097	metal binding residues [ion binding]; metal-binding site
205922001098	3-fold/trimer interface [polypeptide binding]; other site
205922001099	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
205922001100	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
205922001101	putative active site [active]
205922001102	oxyanion strand; other site
205922001103	catalytic triad [active]
205922001104	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
205922001105	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
205922001106	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
205922001107	catalytic residues [active]
205922001108	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
205922001109	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
205922001110	substrate binding site [chemical binding]; other site
205922001111	glutamase interaction surface [polypeptide binding]; other site
205922001112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922001113	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922001114	substrate binding pocket [chemical binding]; other site
205922001115	membrane-bound complex binding site; other site
205922001116	hinge residues; other site
205922001117	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
205922001118	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
205922001119	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
205922001120	NodB motif; other site
205922001121	putative active site [active]
205922001122	putative catalytic site [active]
205922001123	Zn binding site [ion binding]; other site
205922001124	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
205922001125	C-terminal peptidase (prc); Region: prc; TIGR00225
205922001126	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
205922001127	protein binding site [polypeptide binding]; other site
205922001128	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
205922001129	Catalytic dyad [active]
205922001130	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
205922001131	Peptidase family M23; Region: Peptidase_M23; pfam01551
205922001132	phosphoglyceromutase; Provisional; Region: PRK05434
205922001133	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
205922001134	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
205922001135	active site residue [active]
205922001136	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
205922001137	GSH binding site [chemical binding]; other site
205922001138	catalytic residues [active]
205922001139	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
205922001140	SecA binding site; other site
205922001141	Preprotein binding site; other site
205922001142	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
205922001143	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
205922001144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922001145	active site
205922001146	phosphorylation site [posttranslational modification]
205922001147	intermolecular recognition site; other site
205922001148	dimerization interface [polypeptide binding]; other site
205922001149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922001150	Walker A motif; other site
205922001151	ATP binding site [chemical binding]; other site
205922001152	Walker B motif; other site
205922001153	arginine finger; other site
205922001154	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922001155	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
205922001156	PAS domain; Region: PAS; smart00091
205922001157	putative active site [active]
205922001158	heme pocket [chemical binding]; other site
205922001159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922001160	dimer interface [polypeptide binding]; other site
205922001161	phosphorylation site [posttranslational modification]
205922001162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922001163	ATP binding site [chemical binding]; other site
205922001164	Mg2+ binding site [ion binding]; other site
205922001165	G-X-G motif; other site
205922001166	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
205922001167	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
205922001168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
205922001169	glutamine synthetase; Provisional; Region: glnA; PRK09469
205922001170	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
205922001171	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922001172	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
205922001173	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
205922001174	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
205922001175	Ligand Binding Site [chemical binding]; other site
205922001176	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
205922001177	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
205922001178	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
205922001179	G1 box; other site
205922001180	putative GEF interaction site [polypeptide binding]; other site
205922001181	GTP/Mg2+ binding site [chemical binding]; other site
205922001182	Switch I region; other site
205922001183	G2 box; other site
205922001184	G3 box; other site
205922001185	Switch II region; other site
205922001186	G4 box; other site
205922001187	G5 box; other site
205922001188	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
205922001189	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
205922001190	Flagellin N-methylase; Region: FliB; pfam03692
205922001191	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
205922001192	homodimer interface [polypeptide binding]; other site
205922001193	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
205922001194	active site pocket [active]
205922001195	Predicted membrane protein [Function unknown]; Region: COG5373
205922001196	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
205922001197	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
205922001198	fructose-1,6-bisphosphatase family protein; Region: PLN02628
205922001199	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
205922001200	AMP binding site [chemical binding]; other site
205922001201	metal binding site [ion binding]; metal-binding site
205922001202	active site
205922001203	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
205922001204	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
205922001205	Cache domain; Region: Cache_1; pfam02743
205922001206	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922001207	dimerization interface [polypeptide binding]; other site
205922001208	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922001209	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922001210	dimer interface [polypeptide binding]; other site
205922001211	putative CheW interface [polypeptide binding]; other site
205922001212	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
205922001213	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
205922001214	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
205922001215	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
205922001216	active site
205922001217	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
205922001218	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922001219	DNA-binding site [nucleotide binding]; DNA binding site
205922001220	UTRA domain; Region: UTRA; pfam07702
205922001221	HutD; Region: HutD; pfam05962
205922001222	urocanate hydratase; Provisional; Region: PRK05414
205922001223	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
205922001224	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922001225	Na binding site [ion binding]; other site
205922001226	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922001227	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
205922001228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922001229	dimer interface [polypeptide binding]; other site
205922001230	conserved gate region; other site
205922001231	putative PBP binding loops; other site
205922001232	ABC-ATPase subunit interface; other site
205922001233	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922001234	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
205922001235	Walker A/P-loop; other site
205922001236	ATP binding site [chemical binding]; other site
205922001237	Q-loop/lid; other site
205922001238	ABC transporter signature motif; other site
205922001239	Walker B; other site
205922001240	D-loop; other site
205922001241	H-loop/switch region; other site
205922001242	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
205922001243	active sites [active]
205922001244	tetramer interface [polypeptide binding]; other site
205922001245	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
205922001246	active sites [active]
205922001247	tetramer interface [polypeptide binding]; other site
205922001248	imidazolonepropionase; Validated; Region: PRK09356
205922001249	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
205922001250	active site
205922001251	N-formylglutamate amidohydrolase; Region: FGase; cl01522
205922001252	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
205922001253	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922001254	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
205922001255	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
205922001256	TAP-like protein; Region: Abhydrolase_4; pfam08386
205922001257	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
205922001258	putative active site [active]
205922001259	dimerization interface [polypeptide binding]; other site
205922001260	putative tRNAtyr binding site [nucleotide binding]; other site
205922001261	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
205922001262	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
205922001263	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
205922001264	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922001265	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
205922001266	Ligand binding site; other site
205922001267	DXD motif; other site
205922001268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922001269	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922001270	substrate binding pocket [chemical binding]; other site
205922001271	membrane-bound complex binding site; other site
205922001272	hinge residues; other site
205922001273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922001274	dimer interface [polypeptide binding]; other site
205922001275	conserved gate region; other site
205922001276	putative PBP binding loops; other site
205922001277	ABC-ATPase subunit interface; other site
205922001278	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922001279	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922001280	Walker A/P-loop; other site
205922001281	ATP binding site [chemical binding]; other site
205922001282	Q-loop/lid; other site
205922001283	ABC transporter signature motif; other site
205922001284	Walker B; other site
205922001285	D-loop; other site
205922001286	H-loop/switch region; other site
205922001287	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922001288	dimerization interface [polypeptide binding]; other site
205922001289	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922001290	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922001291	dimer interface [polypeptide binding]; other site
205922001292	putative CheW interface [polypeptide binding]; other site
205922001293	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
205922001294	RNA methyltransferase, RsmE family; Region: TIGR00046
205922001295	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
205922001296	sec-independent translocase; Provisional; Region: tatB; PRK00404
205922001297	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
205922001298	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
205922001299	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
205922001300	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
205922001301	metal binding site [ion binding]; metal-binding site
205922001302	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
205922001303	ABC1 family; Region: ABC1; cl17513
205922001304	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
205922001305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
205922001306	SCP-2 sterol transfer family; Region: SCP2; pfam02036
205922001307	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
205922001308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922001309	S-adenosylmethionine binding site [chemical binding]; other site
205922001310	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
205922001311	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
205922001312	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
205922001313	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922001314	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922001315	Bacterial transcriptional repressor; Region: TetR; pfam13972
205922001316	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
205922001317	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
205922001318	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
205922001319	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
205922001320	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
205922001321	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
205922001322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
205922001323	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
205922001324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922001325	Walker A motif; other site
205922001326	ATP binding site [chemical binding]; other site
205922001327	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
205922001328	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
205922001329	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
205922001330	active site
205922001331	HslU subunit interaction site [polypeptide binding]; other site
205922001332	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
205922001333	Sporulation related domain; Region: SPOR; pfam05036
205922001334	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
205922001335	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
205922001336	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
205922001337	active site
205922001338	HIGH motif; other site
205922001339	KMSK motif region; other site
205922001340	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
205922001341	tRNA binding surface [nucleotide binding]; other site
205922001342	anticodon binding site; other site
205922001343	primosome assembly protein PriA; Validated; Region: PRK05580
205922001344	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922001345	ATP binding site [chemical binding]; other site
205922001346	putative Mg++ binding site [ion binding]; other site
205922001347	helicase superfamily c-terminal domain; Region: HELICc; smart00490
205922001348	ATP-binding site [chemical binding]; other site
205922001349	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
205922001350	Staphylococcal nuclease homologues; Region: SNc; smart00318
205922001351	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
205922001352	Catalytic site; other site
205922001353	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
205922001354	Malic enzyme, N-terminal domain; Region: malic; pfam00390
205922001355	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
205922001356	putative NAD(P) binding site [chemical binding]; other site
205922001357	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
205922001358	Transglycosylase; Region: Transgly; pfam00912
205922001359	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
205922001360	Competence protein A; Region: Competence_A; pfam11104
205922001361	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
205922001362	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
205922001363	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
205922001364	Pilus assembly protein, PilO; Region: PilO; pfam04350
205922001365	Pilus assembly protein, PilP; Region: PilP; pfam04351
205922001366	AMIN domain; Region: AMIN; pfam11741
205922001367	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
205922001368	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922001369	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
205922001370	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
205922001371	shikimate kinase; Reviewed; Region: aroK; PRK00131
205922001372	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
205922001373	ADP binding site [chemical binding]; other site
205922001374	magnesium binding site [ion binding]; other site
205922001375	putative shikimate binding site; other site
205922001376	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
205922001377	active site
205922001378	dimer interface [polypeptide binding]; other site
205922001379	metal binding site [ion binding]; metal-binding site
205922001380	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
205922001381	AAA ATPase domain; Region: AAA_16; pfam13191
205922001382	Sporulation related domain; Region: SPOR; pfam05036
205922001383	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
205922001384	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
205922001385	active site
205922001386	dimer interface [polypeptide binding]; other site
205922001387	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
205922001388	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
205922001389	active site
205922001390	FMN binding site [chemical binding]; other site
205922001391	substrate binding site [chemical binding]; other site
205922001392	3Fe-4S cluster binding site [ion binding]; other site
205922001393	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
205922001394	domain interface; other site
205922001395	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
205922001396	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
205922001397	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922001398	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
205922001399	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
205922001400	substrate binding site [chemical binding]; other site
205922001401	active site
205922001402	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
205922001403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922001404	putative substrate translocation pore; other site
205922001405	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
205922001406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922001407	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
205922001408	dimerization interface [polypeptide binding]; other site
205922001409	substrate binding pocket [chemical binding]; other site
205922001410	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
205922001411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922001412	non-specific DNA binding site [nucleotide binding]; other site
205922001413	salt bridge; other site
205922001414	sequence-specific DNA binding site [nucleotide binding]; other site
205922001415	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
205922001416	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205922001417	dimer interface [polypeptide binding]; other site
205922001418	active site
205922001419	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
205922001420	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
205922001421	NAD(P) binding site [chemical binding]; other site
205922001422	homotetramer interface [polypeptide binding]; other site
205922001423	homodimer interface [polypeptide binding]; other site
205922001424	active site
205922001425	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
205922001426	putative active site 1 [active]
205922001427	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
205922001428	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205922001429	dimer interface [polypeptide binding]; other site
205922001430	active site
205922001431	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922001432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922001433	S-adenosylmethionine binding site [chemical binding]; other site
205922001434	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
205922001435	Predicted exporter [General function prediction only]; Region: COG4258
205922001436	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
205922001437	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
205922001438	active site
205922001439	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
205922001440	active sites [active]
205922001441	tetramer interface [polypeptide binding]; other site
205922001442	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
205922001443	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
205922001444	putative acyl-acceptor binding pocket; other site
205922001445	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
205922001446	Ligand binding site; other site
205922001447	Putative Catalytic site; other site
205922001448	DXD motif; other site
205922001449	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922001450	AMP-binding enzyme; Region: AMP-binding; pfam00501
205922001451	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922001452	AMP binding site [chemical binding]; other site
205922001453	active site
205922001454	acyl-activating enzyme (AAE) consensus motif; other site
205922001455	acyl-activating enzyme (AAE) consensus motif; other site
205922001456	CoA binding site [chemical binding]; other site
205922001457	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
205922001458	active site 2 [active]
205922001459	dimer interface [polypeptide binding]; other site
205922001460	active site 1 [active]
205922001461	Predicted membrane protein [Function unknown]; Region: COG4648
205922001462	acyl carrier protein; Provisional; Region: PRK05350
205922001463	Phosphopantetheine attachment site; Region: PP-binding; cl09936
205922001464	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922001465	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
205922001466	putative acyl-acceptor binding pocket; other site
205922001467	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
205922001468	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
205922001469	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922001470	P-loop; other site
205922001471	Magnesium ion binding site [ion binding]; other site
205922001472	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922001473	Magnesium ion binding site [ion binding]; other site
205922001474	thioredoxin 2; Provisional; Region: PRK10996
205922001475	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205922001476	catalytic residues [active]
205922001477	Uncharacterized conserved protein [Function unknown]; Region: COG0397
205922001478	hypothetical protein; Validated; Region: PRK00029
205922001479	hypothetical protein; Provisional; Region: PRK11281
205922001480	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
205922001481	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922001482	potassium/proton antiporter; Reviewed; Region: PRK05326
205922001483	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
205922001484	TrkA-C domain; Region: TrkA_C; pfam02080
205922001485	Transporter associated domain; Region: CorC_HlyC; smart01091
205922001486	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922001487	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922001488	dimerization interface [polypeptide binding]; other site
205922001489	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922001490	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922001491	dimer interface [polypeptide binding]; other site
205922001492	putative CheW interface [polypeptide binding]; other site
205922001493	Cell division protein ZapA; Region: ZapA; pfam05164
205922001494	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922001495	dimerization interface [polypeptide binding]; other site
205922001496	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922001497	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922001498	dimer interface [polypeptide binding]; other site
205922001499	putative CheW interface [polypeptide binding]; other site
205922001500	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
205922001501	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
205922001502	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922001503	active site
205922001504	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
205922001505	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
205922001506	Predicted transcriptional regulator [Transcription]; Region: COG3905
205922001507	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
205922001508	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
205922001509	Glutamate binding site [chemical binding]; other site
205922001510	NAD binding site [chemical binding]; other site
205922001511	catalytic residues [active]
205922001512	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
205922001513	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
205922001514	Na binding site [ion binding]; other site
205922001515	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922001516	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922001517	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922001518	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
205922001519	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
205922001520	methionine sulfoxide reductase A; Provisional; Region: PRK00058
205922001521	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
205922001522	GAF domain; Region: GAF; pfam01590
205922001523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922001524	PAS domain; Region: PAS_9; pfam13426
205922001525	putative active site [active]
205922001526	heme pocket [chemical binding]; other site
205922001527	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922001528	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922001529	metal binding site [ion binding]; metal-binding site
205922001530	active site
205922001531	I-site; other site
205922001532	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922001533	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
205922001534	putative active site [active]
205922001535	putative metal binding site [ion binding]; other site
205922001536	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205922001537	E3 interaction surface; other site
205922001538	lipoyl attachment site [posttranslational modification]; other site
205922001539	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205922001540	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
205922001541	E3 interaction surface; other site
205922001542	lipoyl attachment site [posttranslational modification]; other site
205922001543	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205922001544	E3 interaction surface; other site
205922001545	lipoyl attachment site [posttranslational modification]; other site
205922001546	e3 binding domain; Region: E3_binding; pfam02817
205922001547	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
205922001548	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
205922001549	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
205922001550	dimer interface [polypeptide binding]; other site
205922001551	TPP-binding site [chemical binding]; other site
205922001552	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
205922001553	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
205922001554	metal binding triad; other site
205922001555	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
205922001556	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
205922001557	metal binding triad; other site
205922001558	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
205922001559	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
205922001560	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
205922001561	putative active site [active]
205922001562	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
205922001563	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
205922001564	putative active site [active]
205922001565	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922001566	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
205922001567	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
205922001568	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
205922001569	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
205922001570	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
205922001571	active site
205922001572	ATP binding site [chemical binding]; other site
205922001573	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
205922001574	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
205922001575	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
205922001576	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
205922001577	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
205922001578	putative ADP-binding pocket [chemical binding]; other site
205922001579	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922001580	Mig-14; Region: Mig-14; pfam07395
205922001581	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
205922001582	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
205922001583	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
205922001584	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922001585	putative ADP-binding pocket [chemical binding]; other site
205922001586	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922001587	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922001588	active site
205922001589	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922001590	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
205922001591	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
205922001592	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
205922001593	active site
205922001594	substrate binding site [chemical binding]; other site
205922001595	ATP binding site [chemical binding]; other site
205922001596	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
205922001597	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922001598	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
205922001599	Walker A/P-loop; other site
205922001600	ATP binding site [chemical binding]; other site
205922001601	Q-loop/lid; other site
205922001602	ABC transporter signature motif; other site
205922001603	Walker B; other site
205922001604	D-loop; other site
205922001605	H-loop/switch region; other site
205922001606	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
205922001607	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
205922001608	ligand-binding site [chemical binding]; other site
205922001609	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
205922001610	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
205922001611	putative ribose interaction site [chemical binding]; other site
205922001612	putative ADP binding site [chemical binding]; other site
205922001613	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
205922001614	active site
205922001615	nucleotide binding site [chemical binding]; other site
205922001616	HIGH motif; other site
205922001617	KMSKS motif; other site
205922001618	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922001619	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922001620	active site
205922001621	catalytic tetrad [active]
205922001622	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
205922001623	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922001624	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
205922001625	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922001626	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922001627	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922001628	dimerization interface [polypeptide binding]; other site
205922001629	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
205922001630	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
205922001631	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205922001632	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
205922001633	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
205922001634	ThiC-associated domain; Region: ThiC-associated; pfam13667
205922001635	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
205922001636	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
205922001637	Na binding site [ion binding]; other site
205922001638	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
205922001639	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
205922001640	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
205922001641	dimer interface [polypeptide binding]; other site
205922001642	ADP-ribose binding site [chemical binding]; other site
205922001643	active site
205922001644	nudix motif; other site
205922001645	metal binding site [ion binding]; metal-binding site
205922001646	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
205922001647	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
205922001648	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
205922001649	active site
205922001650	metal binding site [ion binding]; metal-binding site
205922001651	hexamer interface [polypeptide binding]; other site
205922001652	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
205922001653	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922001654	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
205922001655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922001656	ATP binding site [chemical binding]; other site
205922001657	Mg2+ binding site [ion binding]; other site
205922001658	G-X-G motif; other site
205922001659	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
205922001660	anchoring element; other site
205922001661	dimer interface [polypeptide binding]; other site
205922001662	ATP binding site [chemical binding]; other site
205922001663	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
205922001664	active site
205922001665	metal binding site [ion binding]; metal-binding site
205922001666	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
205922001667	SdiA-regulated; Region: SdiA-regulated; cd09971
205922001668	putative active site [active]
205922001669	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
205922001670	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
205922001671	catalytic motif [active]
205922001672	Catalytic residue [active]
205922001673	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
205922001674	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
205922001675	CAP-like domain; other site
205922001676	active site
205922001677	primary dimer interface [polypeptide binding]; other site
205922001678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
205922001679	Protein of unknown function (DUF330); Region: DUF330; pfam03886
205922001680	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
205922001681	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
205922001682	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
205922001683	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
205922001684	phosphoserine phosphatase SerB; Region: serB; TIGR00338
205922001685	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922001686	motif II; other site
205922001687	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
205922001688	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
205922001689	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
205922001690	active site residue [active]
205922001691	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
205922001692	active site residue [active]
205922001693	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
205922001694	flagellar motor protein MotA; Validated; Region: PRK09110
205922001695	flagellar motor protein MotB; Validated; Region: motB; PRK09041
205922001696	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
205922001697	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922001698	ligand binding site [chemical binding]; other site
205922001699	GTPase RsgA; Reviewed; Region: PRK12288
205922001700	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
205922001701	RNA binding site [nucleotide binding]; other site
205922001702	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
205922001703	GTPase/Zn-binding domain interface [polypeptide binding]; other site
205922001704	GTP/Mg2+ binding site [chemical binding]; other site
205922001705	G4 box; other site
205922001706	G5 box; other site
205922001707	G1 box; other site
205922001708	Switch I region; other site
205922001709	G2 box; other site
205922001710	G3 box; other site
205922001711	Switch II region; other site
205922001712	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
205922001713	catalytic site [active]
205922001714	putative active site [active]
205922001715	putative substrate binding site [chemical binding]; other site
205922001716	dimer interface [polypeptide binding]; other site
205922001717	Predicted membrane protein [Function unknown]; Region: COG2860
205922001718	UPF0126 domain; Region: UPF0126; pfam03458
205922001719	UPF0126 domain; Region: UPF0126; pfam03458
205922001720	epoxyqueuosine reductase; Region: TIGR00276
205922001721	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
205922001722	putative carbohydrate kinase; Provisional; Region: PRK10565
205922001723	Uncharacterized conserved protein [Function unknown]; Region: COG0062
205922001724	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
205922001725	putative substrate binding site [chemical binding]; other site
205922001726	putative ATP binding site [chemical binding]; other site
205922001727	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
205922001728	AMIN domain; Region: AMIN; pfam11741
205922001729	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
205922001730	active site
205922001731	metal binding site [ion binding]; metal-binding site
205922001732	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922001733	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
205922001734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922001735	ATP binding site [chemical binding]; other site
205922001736	Mg2+ binding site [ion binding]; other site
205922001737	G-X-G motif; other site
205922001738	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
205922001739	ATP binding site [chemical binding]; other site
205922001740	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
205922001741	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
205922001742	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
205922001743	bacterial Hfq-like; Region: Hfq; cd01716
205922001744	hexamer interface [polypeptide binding]; other site
205922001745	Sm1 motif; other site
205922001746	RNA binding site [nucleotide binding]; other site
205922001747	Sm2 motif; other site
205922001748	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
205922001749	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
205922001750	HflX GTPase family; Region: HflX; cd01878
205922001751	G1 box; other site
205922001752	GTP/Mg2+ binding site [chemical binding]; other site
205922001753	Switch I region; other site
205922001754	G2 box; other site
205922001755	G3 box; other site
205922001756	Switch II region; other site
205922001757	G4 box; other site
205922001758	G5 box; other site
205922001759	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
205922001760	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
205922001761	HflK protein; Region: hflK; TIGR01933
205922001762	HflC protein; Region: hflC; TIGR01932
205922001763	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
205922001764	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
205922001765	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
205922001766	dimer interface [polypeptide binding]; other site
205922001767	motif 1; other site
205922001768	active site
205922001769	motif 2; other site
205922001770	motif 3; other site
205922001771	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
205922001772	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
205922001773	GDP-binding site [chemical binding]; other site
205922001774	ACT binding site; other site
205922001775	IMP binding site; other site
205922001776	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922001777	dimerization interface [polypeptide binding]; other site
205922001778	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922001779	dimer interface [polypeptide binding]; other site
205922001780	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
205922001781	putative CheW interface [polypeptide binding]; other site
205922001782	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
205922001783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922001784	dimer interface [polypeptide binding]; other site
205922001785	conserved gate region; other site
205922001786	putative PBP binding loops; other site
205922001787	ABC-ATPase subunit interface; other site
205922001788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922001789	dimer interface [polypeptide binding]; other site
205922001790	conserved gate region; other site
205922001791	putative PBP binding loops; other site
205922001792	ABC-ATPase subunit interface; other site
205922001793	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205922001794	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205922001795	ribonuclease R; Region: RNase_R; TIGR02063
205922001796	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
205922001797	RNB domain; Region: RNB; pfam00773
205922001798	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
205922001799	RNA binding site [nucleotide binding]; other site
205922001800	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
205922001801	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
205922001802	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
205922001803	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
205922001804	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
205922001805	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
205922001806	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
205922001807	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
205922001808	replicative DNA helicase; Provisional; Region: PRK05748
205922001809	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
205922001810	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
205922001811	Walker A motif; other site
205922001812	ATP binding site [chemical binding]; other site
205922001813	Walker B motif; other site
205922001814	DNA binding loops [nucleotide binding]
205922001815	hypothetical protein; Provisional; Region: PRK01254
205922001816	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
205922001817	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
205922001818	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
205922001819	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
205922001820	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
205922001821	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
205922001822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
205922001823	Uncharacterized conserved protein [Function unknown]; Region: COG2308
205922001824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
205922001825	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
205922001826	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
205922001827	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
205922001828	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
205922001829	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
205922001830	azurin; Region: azurin; TIGR02695
205922001831	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
205922001832	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
205922001833	homodimer interface [polypeptide binding]; other site
205922001834	NAD binding pocket [chemical binding]; other site
205922001835	ATP binding pocket [chemical binding]; other site
205922001836	Mg binding site [ion binding]; other site
205922001837	active-site loop [active]
205922001838	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
205922001839	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
205922001840	active site
205922001841	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922001842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922001843	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922001844	dimerization interface [polypeptide binding]; other site
205922001845	aldehyde dehydrogenase family 7 member; Region: PLN02315
205922001846	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
205922001847	tetrameric interface [polypeptide binding]; other site
205922001848	NAD binding site [chemical binding]; other site
205922001849	catalytic residues [active]
205922001850	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922001851	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922001852	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
205922001853	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
205922001854	dimerization interface [polypeptide binding]; other site
205922001855	ligand binding site [chemical binding]; other site
205922001856	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922001857	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
205922001858	TM-ABC transporter signature motif; other site
205922001859	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
205922001860	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
205922001861	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
205922001862	TM-ABC transporter signature motif; other site
205922001863	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
205922001864	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
205922001865	Walker A/P-loop; other site
205922001866	ATP binding site [chemical binding]; other site
205922001867	Q-loop/lid; other site
205922001868	ABC transporter signature motif; other site
205922001869	Walker B; other site
205922001870	D-loop; other site
205922001871	H-loop/switch region; other site
205922001872	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
205922001873	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
205922001874	Walker A/P-loop; other site
205922001875	ATP binding site [chemical binding]; other site
205922001876	Q-loop/lid; other site
205922001877	ABC transporter signature motif; other site
205922001878	Walker B; other site
205922001879	D-loop; other site
205922001880	H-loop/switch region; other site
205922001881	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
205922001882	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
205922001883	putative NAD(P) binding site [chemical binding]; other site
205922001884	homotetramer interface [polypeptide binding]; other site
205922001885	homodimer interface [polypeptide binding]; other site
205922001886	active site
205922001887	Cation efflux family; Region: Cation_efflux; cl00316
205922001888	dimerization interface [polypeptide binding]; other site
205922001889	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
205922001890	putative active cleft [active]
205922001891	HupE / UreJ protein; Region: HupE_UreJ; cl01011
205922001892	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922001893	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
205922001894	UreF; Region: UreF; pfam01730
205922001895	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
205922001896	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
205922001897	dimer interface [polypeptide binding]; other site
205922001898	catalytic residues [active]
205922001899	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
205922001900	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922001901	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
205922001902	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
205922001903	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
205922001904	Ferritin-like domain; Region: Ferritin; pfam00210
205922001905	dinuclear metal binding motif [ion binding]; other site
205922001906	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922001907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922001908	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922001909	dimerization interface [polypeptide binding]; other site
205922001910	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
205922001911	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922001912	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
205922001913	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
205922001914	Lipase (class 2); Region: Lipase_2; pfam01674
205922001915	EamA-like transporter family; Region: EamA; pfam00892
205922001916	EamA-like transporter family; Region: EamA; pfam00892
205922001917	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922001918	Helix-turn-helix domain; Region: HTH_18; pfam12833
205922001919	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922001920	hypothetical protein; Provisional; Region: PRK11505
205922001921	psiF repeat; Region: PsiF_repeat; pfam07769
205922001922	psiF repeat; Region: PsiF_repeat; pfam07769
205922001923	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
205922001924	putative chaperone; Provisional; Region: PRK11678
205922001925	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
205922001926	nucleotide binding site [chemical binding]; other site
205922001927	putative NEF/HSP70 interaction site [polypeptide binding]; other site
205922001928	SBD interface [polypeptide binding]; other site
205922001929	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
205922001930	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205922001931	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
205922001932	substrate binding site [polypeptide binding]; other site
205922001933	dimer interface [polypeptide binding]; other site
205922001934	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
205922001935	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
205922001936	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922001937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922001938	dimer interface [polypeptide binding]; other site
205922001939	phosphorylation site [posttranslational modification]
205922001940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922001941	ATP binding site [chemical binding]; other site
205922001942	Mg2+ binding site [ion binding]; other site
205922001943	G-X-G motif; other site
205922001944	urease subunit alpha; Reviewed; Region: ureC; PRK13207
205922001945	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
205922001946	subunit interactions [polypeptide binding]; other site
205922001947	active site
205922001948	flap region; other site
205922001949	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
205922001950	gamma-beta subunit interface [polypeptide binding]; other site
205922001951	alpha-beta subunit interface [polypeptide binding]; other site
205922001952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922001953	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922001954	Coenzyme A binding pocket [chemical binding]; other site
205922001955	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
205922001956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922001957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922001958	Coenzyme A binding pocket [chemical binding]; other site
205922001959	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
205922001960	alpha-gamma subunit interface [polypeptide binding]; other site
205922001961	beta-gamma subunit interface [polypeptide binding]; other site
205922001962	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
205922001963	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
205922001964	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
205922001965	Walker A/P-loop; other site
205922001966	ATP binding site [chemical binding]; other site
205922001967	Q-loop/lid; other site
205922001968	ABC transporter signature motif; other site
205922001969	Walker B; other site
205922001970	D-loop; other site
205922001971	H-loop/switch region; other site
205922001972	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
205922001973	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
205922001974	Walker A/P-loop; other site
205922001975	ATP binding site [chemical binding]; other site
205922001976	Q-loop/lid; other site
205922001977	ABC transporter signature motif; other site
205922001978	Walker B; other site
205922001979	D-loop; other site
205922001980	H-loop/switch region; other site
205922001981	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
205922001982	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
205922001983	TM-ABC transporter signature motif; other site
205922001984	HEAT repeats; Region: HEAT_2; pfam13646
205922001985	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
205922001986	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922001987	TM-ABC transporter signature motif; other site
205922001988	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
205922001989	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
205922001990	putative ligand binding site [chemical binding]; other site
205922001991	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
205922001992	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205922001993	ABC-ATPase subunit  interface; other site
205922001994	dimer interface [polypeptide binding]; other site
205922001995	putative PBP binding regions; other site
205922001996	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
205922001997	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
205922001998	putative ligand binding residues [chemical binding]; other site
205922001999	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
205922002000	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
205922002001	Walker A/P-loop; other site
205922002002	ATP binding site [chemical binding]; other site
205922002003	Q-loop/lid; other site
205922002004	ABC transporter signature motif; other site
205922002005	Walker B; other site
205922002006	D-loop; other site
205922002007	H-loop/switch region; other site
205922002008	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922002009	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922002010	N-terminal plug; other site
205922002011	ligand-binding site [chemical binding]; other site
205922002012	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
205922002013	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
205922002014	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205922002015	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
205922002016	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205922002017	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
205922002018	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922002019	N-terminal plug; other site
205922002020	ligand-binding site [chemical binding]; other site
205922002021	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
205922002022	Protein of unknown function (DUF461); Region: DUF461; pfam04314
205922002023	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
205922002024	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
205922002025	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
205922002026	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
205922002027	active site
205922002028	putative homodimer interface [polypeptide binding]; other site
205922002029	SAM binding site [chemical binding]; other site
205922002030	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
205922002031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922002032	S-adenosylmethionine binding site [chemical binding]; other site
205922002033	precorrin-3B synthase; Region: CobG; TIGR02435
205922002034	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922002035	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922002036	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
205922002037	Precorrin-8X methylmutase; Region: CbiC; pfam02570
205922002038	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
205922002039	active site
205922002040	SAM binding site [chemical binding]; other site
205922002041	homodimer interface [polypeptide binding]; other site
205922002042	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
205922002043	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
205922002044	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
205922002045	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
205922002046	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
205922002047	active site
205922002048	SAM binding site [chemical binding]; other site
205922002049	homodimer interface [polypeptide binding]; other site
205922002050	TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918
205922002051	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
205922002052	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
205922002053	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
205922002054	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
205922002055	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
205922002056	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
205922002057	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
205922002058	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
205922002059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922002060	dimer interface [polypeptide binding]; other site
205922002061	phosphorylation site [posttranslational modification]
205922002062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922002063	ATP binding site [chemical binding]; other site
205922002064	Mg2+ binding site [ion binding]; other site
205922002065	G-X-G motif; other site
205922002066	Response regulator receiver domain; Region: Response_reg; pfam00072
205922002067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922002068	active site
205922002069	phosphorylation site [posttranslational modification]
205922002070	intermolecular recognition site; other site
205922002071	dimerization interface [polypeptide binding]; other site
205922002072	Response regulator receiver domain; Region: Response_reg; pfam00072
205922002073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922002074	active site
205922002075	phosphorylation site [posttranslational modification]
205922002076	intermolecular recognition site; other site
205922002077	dimerization interface [polypeptide binding]; other site
205922002078	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
205922002079	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
205922002080	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
205922002081	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
205922002082	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
205922002083	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
205922002084	purine monophosphate binding site [chemical binding]; other site
205922002085	dimer interface [polypeptide binding]; other site
205922002086	putative catalytic residues [active]
205922002087	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
205922002088	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
205922002089	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
205922002090	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
205922002091	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
205922002092	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
205922002093	FMN binding site [chemical binding]; other site
205922002094	active site
205922002095	catalytic residues [active]
205922002096	substrate binding site [chemical binding]; other site
205922002097	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
205922002098	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
205922002099	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
205922002100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922002101	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
205922002102	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922002103	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205922002104	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
205922002105	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
205922002106	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922002107	carboxyltransferase (CT) interaction site; other site
205922002108	biotinylation site [posttranslational modification]; other site
205922002109	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
205922002110	Dehydroquinase class II; Region: DHquinase_II; pfam01220
205922002111	active site
205922002112	trimer interface [polypeptide binding]; other site
205922002113	dimer interface [polypeptide binding]; other site
205922002114	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
205922002115	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
205922002116	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
205922002117	DsbD alpha interface [polypeptide binding]; other site
205922002118	catalytic residues [active]
205922002119	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922002120	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922002121	dimer interface [polypeptide binding]; other site
205922002122	putative CheW interface [polypeptide binding]; other site
205922002123	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
205922002124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922002125	active site
205922002126	phosphorylation site [posttranslational modification]
205922002127	intermolecular recognition site; other site
205922002128	dimerization interface [polypeptide binding]; other site
205922002129	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922002130	metal binding site [ion binding]; metal-binding site
205922002131	active site
205922002132	I-site; other site
205922002133	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
205922002134	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
205922002135	nudix motif; other site
205922002136	translation initiation factor Sui1; Validated; Region: PRK06824
205922002137	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
205922002138	putative rRNA binding site [nucleotide binding]; other site
205922002139	arginine decarboxylase; Provisional; Region: PRK05354
205922002140	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
205922002141	dimer interface [polypeptide binding]; other site
205922002142	active site
205922002143	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922002144	catalytic residues [active]
205922002145	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
205922002146	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922002147	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922002148	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
205922002149	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
205922002150	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
205922002151	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
205922002152	homodimer interface [polypeptide binding]; other site
205922002153	chemical substrate binding site [chemical binding]; other site
205922002154	oligomer interface [polypeptide binding]; other site
205922002155	metal binding site [ion binding]; metal-binding site
205922002156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922002157	S-adenosylmethionine binding site [chemical binding]; other site
205922002158	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
205922002159	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
205922002160	Predicted membrane protein [Function unknown]; Region: COG4655
205922002161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922002162	putative active site [active]
205922002163	heme pocket [chemical binding]; other site
205922002164	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922002165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922002166	putative active site [active]
205922002167	heme pocket [chemical binding]; other site
205922002168	PAS domain; Region: PAS; smart00091
205922002169	putative active site [active]
205922002170	heme pocket [chemical binding]; other site
205922002171	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922002172	dimer interface [polypeptide binding]; other site
205922002173	phosphorylation site [posttranslational modification]
205922002174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922002175	ATP binding site [chemical binding]; other site
205922002176	Mg2+ binding site [ion binding]; other site
205922002177	G-X-G motif; other site
205922002178	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922002179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922002180	active site
205922002181	phosphorylation site [posttranslational modification]
205922002182	intermolecular recognition site; other site
205922002183	dimerization interface [polypeptide binding]; other site
205922002184	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922002185	DNA binding residues [nucleotide binding]
205922002186	dimerization interface [polypeptide binding]; other site
205922002187	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
205922002188	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
205922002189	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
205922002190	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
205922002191	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922002192	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
205922002193	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
205922002194	ATP binding site [chemical binding]; other site
205922002195	Walker A motif; other site
205922002196	hexamer interface [polypeptide binding]; other site
205922002197	Walker B motif; other site
205922002198	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
205922002199	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
205922002200	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
205922002201	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
205922002202	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
205922002203	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
205922002204	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
205922002205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922002206	active site
205922002207	phosphorylation site [posttranslational modification]
205922002208	intermolecular recognition site; other site
205922002209	dimerization interface [polypeptide binding]; other site
205922002210	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
205922002211	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
205922002212	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
205922002213	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
205922002214	active site 2 [active]
205922002215	active site 1 [active]
205922002216	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
205922002217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922002218	NAD(P) binding site [chemical binding]; other site
205922002219	active site
205922002220	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
205922002221	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922002222	dimer interface [polypeptide binding]; other site
205922002223	active site
205922002224	Cache domain; Region: Cache_1; pfam02743
205922002225	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922002226	dimerization interface [polypeptide binding]; other site
205922002227	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922002228	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922002229	dimer interface [polypeptide binding]; other site
205922002230	putative CheW interface [polypeptide binding]; other site
205922002231	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
205922002232	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
205922002233	ATP binding site [chemical binding]; other site
205922002234	H+ Antiporter protein; Region: 2A0121; TIGR00900
205922002235	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
205922002236	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
205922002237	DNA binding residues [nucleotide binding]
205922002238	dimer interface [polypeptide binding]; other site
205922002239	copper binding site [ion binding]; other site
205922002240	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
205922002241	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
205922002242	metal-binding site [ion binding]
205922002243	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
205922002244	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
205922002245	metal-binding site [ion binding]
205922002246	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205922002247	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
205922002248	metal-binding site [ion binding]
205922002249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922002250	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
205922002251	putative substrate translocation pore; other site
205922002252	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
205922002253	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
205922002254	putative NAD(P) binding site [chemical binding]; other site
205922002255	dimer interface [polypeptide binding]; other site
205922002256	Uncharacterized conserved protein [Function unknown]; Region: COG1359
205922002257	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922002258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922002259	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922002260	putative effector binding pocket; other site
205922002261	dimerization interface [polypeptide binding]; other site
205922002262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922002263	putative DNA binding site [nucleotide binding]; other site
205922002264	putative Zn2+ binding site [ion binding]; other site
205922002265	benzoate transport; Region: 2A0115; TIGR00895
205922002266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922002267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922002268	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
205922002269	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
205922002270	active site
205922002271	purine riboside binding site [chemical binding]; other site
205922002272	oxidase reductase; Provisional; Region: PTZ00273
205922002273	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
205922002274	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
205922002275	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
205922002276	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
205922002277	putative ligand binding site [chemical binding]; other site
205922002278	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
205922002279	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
205922002280	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
205922002281	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
205922002282	active site
205922002283	putative substrate binding pocket [chemical binding]; other site
205922002284	C factor cell-cell signaling protein; Provisional; Region: PRK09009
205922002285	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
205922002286	NADP binding site [chemical binding]; other site
205922002287	homodimer interface [polypeptide binding]; other site
205922002288	active site
205922002289	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
205922002290	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
205922002291	DNA binding residues [nucleotide binding]
205922002292	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922002293	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
205922002294	TM-ABC transporter signature motif; other site
205922002295	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922002296	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
205922002297	TM-ABC transporter signature motif; other site
205922002298	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
205922002299	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205922002300	Walker A/P-loop; other site
205922002301	ATP binding site [chemical binding]; other site
205922002302	Q-loop/lid; other site
205922002303	ABC transporter signature motif; other site
205922002304	Walker B; other site
205922002305	D-loop; other site
205922002306	H-loop/switch region; other site
205922002307	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205922002308	Uncharacterized conserved protein [Function unknown]; Region: COG1739
205922002309	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
205922002310	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
205922002311	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
205922002312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922002313	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
205922002314	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922002315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922002316	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922002317	dimerization interface [polypeptide binding]; other site
205922002318	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
205922002319	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922002320	inhibitor-cofactor binding pocket; inhibition site
205922002321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922002322	catalytic residue [active]
205922002323	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
205922002324	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
205922002325	tetrameric interface [polypeptide binding]; other site
205922002326	NAD binding site [chemical binding]; other site
205922002327	catalytic residues [active]
205922002328	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
205922002329	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
205922002330	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
205922002331	Family description; Region: UvrD_C_2; pfam13538
205922002332	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
205922002333	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
205922002334	AAA domain; Region: AAA_30; pfam13604
205922002335	Family description; Region: UvrD_C_2; pfam13538
205922002336	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
205922002337	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
205922002338	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922002339	metal binding site [ion binding]; metal-binding site
205922002340	active site
205922002341	I-site; other site
205922002342	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922002343	ligand binding site [chemical binding]; other site
205922002344	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922002345	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922002346	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922002347	dimerization interface [polypeptide binding]; other site
205922002348	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
205922002349	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
205922002350	tetrameric interface [polypeptide binding]; other site
205922002351	NAD binding site [chemical binding]; other site
205922002352	catalytic residues [active]
205922002353	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
205922002354	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
205922002355	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
205922002356	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
205922002357	putative trimer interface [polypeptide binding]; other site
205922002358	putative CoA binding site [chemical binding]; other site
205922002359	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
205922002360	putative trimer interface [polypeptide binding]; other site
205922002361	putative CoA binding site [chemical binding]; other site
205922002362	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205922002363	Protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). The protein prenyltransferase family of lipid-modifying enzymes includes protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I...; Region: PTase; cd02890
205922002364	active site cavity [active]
205922002365	peptide binding pocket; other site
205922002366	lipid binding pocket [chemical binding]; lipid-binding site
205922002367	heterodimer interface [polypeptide binding]; other site
205922002368	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
205922002369	Zn2+ binding site [ion binding]; other site
205922002370	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
205922002371	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
205922002372	NAD binding site [chemical binding]; other site
205922002373	substrate binding site [chemical binding]; other site
205922002374	homodimer interface [polypeptide binding]; other site
205922002375	active site
205922002376	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
205922002377	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
205922002378	substrate binding site; other site
205922002379	tetramer interface; other site
205922002380	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
205922002381	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
205922002382	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
205922002383	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
205922002384	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922002385	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922002386	active site
205922002387	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922002388	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922002389	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
205922002390	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922002391	multidrug efflux protein; Reviewed; Region: PRK09579
205922002392	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922002393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922002394	dimerization interface [polypeptide binding]; other site
205922002395	putative DNA binding site [nucleotide binding]; other site
205922002396	Chorismate lyase; Region: Chor_lyase; cl01230
205922002397	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922002398	Flavin Reductases; Region: FlaRed; cl00801
205922002399	Helix-Turn-Helix DNA binding domain of MerR2-like transcription regulators; Region: HTH_MerR2; cd04769
205922002400	DNA binding residues [nucleotide binding]
205922002401	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205922002402	putative dimer interface [polypeptide binding]; other site
205922002403	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
205922002404	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922002405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922002406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922002407	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
205922002408	putative dimerization interface [polypeptide binding]; other site
205922002409	Uncharacterized conserved protein [Function unknown]; Region: COG1359
205922002410	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
205922002411	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922002412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922002413	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922002414	dimerization interface [polypeptide binding]; other site
205922002415	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922002416	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922002417	NAD(P) binding site [chemical binding]; other site
205922002418	active site
205922002419	fructuronate transporter; Provisional; Region: PRK10034; cl15264
205922002420	GntP family permease; Region: GntP_permease; pfam02447
205922002421	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
205922002422	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
205922002423	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
205922002424	putative active site [active]
205922002425	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
205922002426	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
205922002427	active site
205922002428	putative substrate binding pocket [chemical binding]; other site
205922002429	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
205922002430	dimer interface [polypeptide binding]; other site
205922002431	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922002432	ligand binding site [chemical binding]; other site
205922002433	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922002434	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922002435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922002436	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
205922002437	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922002438	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922002439	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922002440	dimerization interface [polypeptide binding]; other site
205922002441	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922002442	dimer interface [polypeptide binding]; other site
205922002443	putative CheW interface [polypeptide binding]; other site
205922002444	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
205922002445	catalytic core [active]
205922002446	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
205922002447	active site
205922002448	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
205922002449	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
205922002450	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
205922002451	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922002452	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922002453	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
205922002454	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922002455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922002456	S-adenosylmethionine binding site [chemical binding]; other site
205922002457	DNA sulfur modification protein DndB; Region: DNA_S_dndB; TIGR03233
205922002458	DGQHR domain; Region: DGQHR; TIGR03187
205922002459	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
205922002460	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
205922002461	Active Sites [active]
205922002462	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
205922002463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922002464	Walker A/P-loop; other site
205922002465	ATP binding site [chemical binding]; other site
205922002466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922002467	ABC transporter signature motif; other site
205922002468	Walker B; other site
205922002469	D-loop; other site
205922002470	H-loop/switch region; other site
205922002471	DNA sulfur modification protein DndE; Region: DNA_S_dndE; TIGR03184
205922002472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922002473	ATP binding site [chemical binding]; other site
205922002474	Mg2+ binding site [ion binding]; other site
205922002475	G-X-G motif; other site
205922002476	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
205922002477	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
205922002478	active site
205922002479	catalytic residues [active]
205922002480	Int/Topo IB signature motif; other site
205922002481	DNA binding site [nucleotide binding]
205922002482	integrase; Provisional; Region: PRK09692
205922002483	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
205922002484	active site
205922002485	Int/Topo IB signature motif; other site
205922002486	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
205922002487	FAD binding domain; Region: FAD_binding_4; pfam01565
205922002488	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
205922002489	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
205922002490	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
205922002491	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
205922002492	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
205922002493	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
205922002494	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
205922002495	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
205922002496	Cysteine-rich domain; Region: CCG; pfam02754
205922002497	Cysteine-rich domain; Region: CCG; pfam02754
205922002498	glycolate transporter; Provisional; Region: PRK09695
205922002499	L-lactate permease; Region: Lactate_perm; cl00701
205922002500	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
205922002501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922002502	DNA-binding site [nucleotide binding]; DNA binding site
205922002503	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
205922002504	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
205922002505	SmpB-tmRNA interface; other site
205922002506	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
205922002507	Na2 binding site [ion binding]; other site
205922002508	putative substrate binding site 1 [chemical binding]; other site
205922002509	Na binding site 1 [ion binding]; other site
205922002510	putative substrate binding site 2 [chemical binding]; other site
205922002511	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
205922002512	putative coenzyme Q binding site [chemical binding]; other site
205922002513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
205922002514	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
205922002515	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
205922002516	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
205922002517	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
205922002518	metal binding site 2 [ion binding]; metal-binding site
205922002519	putative DNA binding helix; other site
205922002520	metal binding site 1 [ion binding]; metal-binding site
205922002521	dimer interface [polypeptide binding]; other site
205922002522	structural Zn2+ binding site [ion binding]; other site
205922002523	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
205922002524	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
205922002525	Walker A/P-loop; other site
205922002526	ATP binding site [chemical binding]; other site
205922002527	Q-loop/lid; other site
205922002528	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
205922002529	Q-loop/lid; other site
205922002530	ABC transporter signature motif; other site
205922002531	Walker B; other site
205922002532	D-loop; other site
205922002533	H-loop/switch region; other site
205922002534	GrpE; Region: GrpE; pfam01025
205922002535	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
205922002536	dimer interface [polypeptide binding]; other site
205922002537	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
205922002538	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
205922002539	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
205922002540	nucleotide binding site [chemical binding]; other site
205922002541	NEF interaction site [polypeptide binding]; other site
205922002542	SBD interface [polypeptide binding]; other site
205922002543	chaperone protein DnaJ; Provisional; Region: PRK10767
205922002544	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205922002545	HSP70 interaction site [polypeptide binding]; other site
205922002546	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
205922002547	substrate binding site [polypeptide binding]; other site
205922002548	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
205922002549	Zn binding sites [ion binding]; other site
205922002550	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
205922002551	dimer interface [polypeptide binding]; other site
205922002552	dihydrodipicolinate reductase; Provisional; Region: PRK00048
205922002553	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
205922002554	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
205922002555	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
205922002556	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
205922002557	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
205922002558	catalytic site [active]
205922002559	subunit interface [polypeptide binding]; other site
205922002560	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
205922002561	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922002562	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205922002563	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
205922002564	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922002565	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205922002566	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
205922002567	IMP binding site; other site
205922002568	dimer interface [polypeptide binding]; other site
205922002569	interdomain contacts; other site
205922002570	partial ornithine binding site; other site
205922002571	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
205922002572	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
205922002573	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
205922002574	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
205922002575	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
205922002576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922002577	S-adenosylmethionine binding site [chemical binding]; other site
205922002578	FtsH Extracellular; Region: FtsH_ext; pfam06480
205922002579	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
205922002580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922002581	Walker A motif; other site
205922002582	ATP binding site [chemical binding]; other site
205922002583	Walker B motif; other site
205922002584	arginine finger; other site
205922002585	Peptidase family M41; Region: Peptidase_M41; pfam01434
205922002586	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
205922002587	dihydropteroate synthase; Region: DHPS; TIGR01496
205922002588	substrate binding pocket [chemical binding]; other site
205922002589	dimer interface [polypeptide binding]; other site
205922002590	inhibitor binding site; inhibition site
205922002591	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
205922002592	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
205922002593	active site
205922002594	substrate binding site [chemical binding]; other site
205922002595	metal binding site [ion binding]; metal-binding site
205922002596	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
205922002597	triosephosphate isomerase; Provisional; Region: PRK14567
205922002598	substrate binding site [chemical binding]; other site
205922002599	dimer interface [polypeptide binding]; other site
205922002600	catalytic triad [active]
205922002601	Preprotein translocase SecG subunit; Region: SecG; pfam03840
205922002602	ribosome maturation protein RimP; Reviewed; Region: PRK00092
205922002603	Sm and related proteins; Region: Sm_like; cl00259
205922002604	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
205922002605	putative oligomer interface [polypeptide binding]; other site
205922002606	putative RNA binding site [nucleotide binding]; other site
205922002607	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
205922002608	NusA N-terminal domain; Region: NusA_N; pfam08529
205922002609	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
205922002610	RNA binding site [nucleotide binding]; other site
205922002611	homodimer interface [polypeptide binding]; other site
205922002612	NusA-like KH domain; Region: KH_5; pfam13184
205922002613	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
205922002614	G-X-X-G motif; other site
205922002615	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
205922002616	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
205922002617	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
205922002618	translation initiation factor IF-2; Region: IF-2; TIGR00487
205922002619	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
205922002620	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
205922002621	G1 box; other site
205922002622	putative GEF interaction site [polypeptide binding]; other site
205922002623	GTP/Mg2+ binding site [chemical binding]; other site
205922002624	Switch I region; other site
205922002625	G2 box; other site
205922002626	G3 box; other site
205922002627	Switch II region; other site
205922002628	G4 box; other site
205922002629	G5 box; other site
205922002630	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
205922002631	Translation-initiation factor 2; Region: IF-2; pfam11987
205922002632	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
205922002633	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
205922002634	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
205922002635	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
205922002636	RNA binding site [nucleotide binding]; other site
205922002637	active site
205922002638	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
205922002639	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
205922002640	16S/18S rRNA binding site [nucleotide binding]; other site
205922002641	S13e-L30e interaction site [polypeptide binding]; other site
205922002642	25S rRNA binding site [nucleotide binding]; other site
205922002643	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
205922002644	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
205922002645	RNase E interface [polypeptide binding]; other site
205922002646	trimer interface [polypeptide binding]; other site
205922002647	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
205922002648	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
205922002649	RNase E interface [polypeptide binding]; other site
205922002650	trimer interface [polypeptide binding]; other site
205922002651	active site
205922002652	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
205922002653	putative nucleic acid binding region [nucleotide binding]; other site
205922002654	G-X-X-G motif; other site
205922002655	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
205922002656	RNA binding site [nucleotide binding]; other site
205922002657	domain interface; other site
205922002658	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
205922002659	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
205922002660	dimerization interface [polypeptide binding]; other site
205922002661	active site
205922002662	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
205922002663	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
205922002664	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
205922002665	amidase catalytic site [active]
205922002666	Zn binding residues [ion binding]; other site
205922002667	substrate binding site [chemical binding]; other site
205922002668	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
205922002669	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922002670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922002671	dimerization interface [polypeptide binding]; other site
205922002672	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922002673	dimer interface [polypeptide binding]; other site
205922002674	putative CheW interface [polypeptide binding]; other site
205922002675	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
205922002676	active site
205922002677	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
205922002678	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205922002679	DNA binding site [nucleotide binding]
205922002680	domain linker motif; other site
205922002681	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
205922002682	dimerization interface [polypeptide binding]; other site
205922002683	ligand binding site [chemical binding]; other site
205922002684	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205922002685	active site
205922002686	phosphorylation site [posttranslational modification]
205922002687	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
205922002688	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
205922002689	regulatory protein interface [polypeptide binding]; other site
205922002690	active site
205922002691	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
205922002692	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
205922002693	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205922002694	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
205922002695	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
205922002696	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
205922002697	putative substrate binding site [chemical binding]; other site
205922002698	putative ATP binding site [chemical binding]; other site
205922002699	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
205922002700	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
205922002701	active site
205922002702	P-loop; other site
205922002703	phosphorylation site [posttranslational modification]
205922002704	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
205922002705	active site
205922002706	P-loop; other site
205922002707	phosphorylation site [posttranslational modification]
205922002708	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
205922002709	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
205922002710	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
205922002711	putative active site [active]
205922002712	putative metal binding site [ion binding]; other site
205922002713	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
205922002714	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
205922002715	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
205922002716	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
205922002717	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
205922002718	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
205922002719	Flavodoxin; Region: Flavodoxin_1; pfam00258
205922002720	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
205922002721	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
205922002722	FAD binding pocket [chemical binding]; other site
205922002723	FAD binding motif [chemical binding]; other site
205922002724	catalytic residues [active]
205922002725	NAD binding pocket [chemical binding]; other site
205922002726	phosphate binding motif [ion binding]; other site
205922002727	beta-alpha-beta structure motif; other site
205922002728	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
205922002729	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922002730	N-terminal plug; other site
205922002731	ligand-binding site [chemical binding]; other site
205922002732	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
205922002733	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922002734	Sel1-like repeats; Region: SEL1; smart00671
205922002735	Sel1-like repeats; Region: SEL1; smart00671
205922002736	Sel1-like repeats; Region: SEL1; smart00671
205922002737	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
205922002738	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
205922002739	dimer interface [polypeptide binding]; other site
205922002740	active site
205922002741	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922002742	catalytic residues [active]
205922002743	substrate binding site [chemical binding]; other site
205922002744	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
205922002745	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
205922002746	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
205922002747	Walker A/P-loop; other site
205922002748	ATP binding site [chemical binding]; other site
205922002749	Q-loop/lid; other site
205922002750	ABC transporter signature motif; other site
205922002751	Walker B; other site
205922002752	D-loop; other site
205922002753	H-loop/switch region; other site
205922002754	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
205922002755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922002756	dimer interface [polypeptide binding]; other site
205922002757	conserved gate region; other site
205922002758	ABC-ATPase subunit interface; other site
205922002759	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
205922002760	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
205922002761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922002762	ABC-ATPase subunit interface; other site
205922002763	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
205922002764	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
205922002765	G1 box; other site
205922002766	putative GEF interaction site [polypeptide binding]; other site
205922002767	GTP/Mg2+ binding site [chemical binding]; other site
205922002768	Switch I region; other site
205922002769	G2 box; other site
205922002770	G3 box; other site
205922002771	Switch II region; other site
205922002772	G4 box; other site
205922002773	G5 box; other site
205922002774	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
205922002775	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
205922002776	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922002777	Walker A/P-loop; other site
205922002778	ATP binding site [chemical binding]; other site
205922002779	Q-loop/lid; other site
205922002780	ABC transporter signature motif; other site
205922002781	Walker B; other site
205922002782	D-loop; other site
205922002783	H-loop/switch region; other site
205922002784	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922002785	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
205922002786	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922002787	Walker A/P-loop; other site
205922002788	ATP binding site [chemical binding]; other site
205922002789	Q-loop/lid; other site
205922002790	ABC transporter signature motif; other site
205922002791	Walker B; other site
205922002792	D-loop; other site
205922002793	H-loop/switch region; other site
205922002794	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922002795	dipeptide transporter; Provisional; Region: PRK10913
205922002796	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
205922002797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922002798	dimer interface [polypeptide binding]; other site
205922002799	conserved gate region; other site
205922002800	putative PBP binding loops; other site
205922002801	ABC-ATPase subunit interface; other site
205922002802	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
205922002803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922002804	dimer interface [polypeptide binding]; other site
205922002805	conserved gate region; other site
205922002806	putative PBP binding loops; other site
205922002807	ABC-ATPase subunit interface; other site
205922002808	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
205922002809	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
205922002810	peptide binding site [polypeptide binding]; other site
205922002811	outer membrane porin, OprD family; Region: OprD; pfam03573
205922002812	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
205922002813	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
205922002814	peptide binding site [polypeptide binding]; other site
205922002815	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
205922002816	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
205922002817	peptide binding site [polypeptide binding]; other site
205922002818	Uncharacterized conserved protein [Function unknown]; Region: COG2968
205922002819	Protein of unknown function (DUF541); Region: SIMPL; cl01077
205922002820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922002821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922002822	ATP binding site [chemical binding]; other site
205922002823	G-X-G motif; other site
205922002824	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
205922002825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922002826	active site
205922002827	phosphorylation site [posttranslational modification]
205922002828	intermolecular recognition site; other site
205922002829	dimerization interface [polypeptide binding]; other site
205922002830	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922002831	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
205922002832	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
205922002833	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
205922002834	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922002835	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922002836	DNA-binding site [nucleotide binding]; DNA binding site
205922002837	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
205922002838	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
205922002839	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
205922002840	putative active site [active]
205922002841	catalytic residue [active]
205922002842	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
205922002843	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922002844	NAD(P) binding site [chemical binding]; other site
205922002845	catalytic residues [active]
205922002846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922002847	D-galactonate transporter; Region: 2A0114; TIGR00893
205922002848	putative substrate translocation pore; other site
205922002849	galactarate dehydratase; Region: galactar-dH20; TIGR03248
205922002850	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
205922002851	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
205922002852	Predicted permeases [General function prediction only]; Region: COG0679
205922002853	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
205922002854	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
205922002855	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
205922002856	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
205922002857	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
205922002858	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
205922002859	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
205922002860	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
205922002861	GatB domain; Region: GatB_Yqey; smart00845
205922002862	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
205922002863	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
205922002864	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
205922002865	rod shape-determining protein MreB; Provisional; Region: PRK13927
205922002866	MreB and similar proteins; Region: MreB_like; cd10225
205922002867	nucleotide binding site [chemical binding]; other site
205922002868	Mg binding site [ion binding]; other site
205922002869	putative protofilament interaction site [polypeptide binding]; other site
205922002870	RodZ interaction site [polypeptide binding]; other site
205922002871	rod shape-determining protein MreC; Provisional; Region: PRK13922
205922002872	rod shape-determining protein MreC; Region: MreC; pfam04085
205922002873	rod shape-determining protein MreD; Region: MreD; cl01087
205922002874	Maf-like protein; Region: Maf; pfam02545
205922002875	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
205922002876	active site
205922002877	dimer interface [polypeptide binding]; other site
205922002878	ribonuclease G; Provisional; Region: PRK11712
205922002879	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
205922002880	homodimer interface [polypeptide binding]; other site
205922002881	oligonucleotide binding site [chemical binding]; other site
205922002882	TIGR02099 family protein; Region: TIGR02099
205922002883	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
205922002884	nitrilase; Region: PLN02798
205922002885	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
205922002886	putative active site [active]
205922002887	catalytic triad [active]
205922002888	dimer interface [polypeptide binding]; other site
205922002889	protease TldD; Provisional; Region: tldD; PRK10735
205922002890	hypothetical protein; Provisional; Region: PRK05255
205922002891	peptidase PmbA; Provisional; Region: PRK11040
205922002892	fumarate hydratase; Reviewed; Region: fumC; PRK00485
205922002893	Class II fumarases; Region: Fumarase_classII; cd01362
205922002894	active site
205922002895	tetramer interface [polypeptide binding]; other site
205922002896	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
205922002897	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
205922002898	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
205922002899	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
205922002900	ZIP Zinc transporter; Region: Zip; pfam02535
205922002901	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
205922002902	dimerization domain swap beta strand [polypeptide binding]; other site
205922002903	regulatory protein interface [polypeptide binding]; other site
205922002904	active site
205922002905	regulatory phosphorylation site [posttranslational modification]; other site
205922002906	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
205922002907	AAA domain; Region: AAA_18; pfam13238
205922002908	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
205922002909	active site
205922002910	phosphorylation site [posttranslational modification]
205922002911	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
205922002912	30S subunit binding site; other site
205922002913	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
205922002914	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
205922002915	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
205922002916	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
205922002917	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
205922002918	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
205922002919	Walker A/P-loop; other site
205922002920	ATP binding site [chemical binding]; other site
205922002921	Q-loop/lid; other site
205922002922	ABC transporter signature motif; other site
205922002923	Walker B; other site
205922002924	D-loop; other site
205922002925	H-loop/switch region; other site
205922002926	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
205922002927	OstA-like protein; Region: OstA; pfam03968
205922002928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
205922002929	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
205922002930	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
205922002931	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922002932	active site
205922002933	motif I; other site
205922002934	motif II; other site
205922002935	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
205922002936	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
205922002937	putative active site [active]
205922002938	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
205922002939	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
205922002940	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
205922002941	Walker A/P-loop; other site
205922002942	ATP binding site [chemical binding]; other site
205922002943	Q-loop/lid; other site
205922002944	ABC transporter signature motif; other site
205922002945	Walker B; other site
205922002946	D-loop; other site
205922002947	H-loop/switch region; other site
205922002948	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
205922002949	Permease; Region: Permease; cl00510
205922002950	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
205922002951	mce related protein; Region: MCE; pfam02470
205922002952	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
205922002953	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
205922002954	anti sigma factor interaction site; other site
205922002955	regulatory phosphorylation site [posttranslational modification]; other site
205922002956	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
205922002957	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
205922002958	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
205922002959	hinge; other site
205922002960	active site
205922002961	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
205922002962	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
205922002963	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
205922002964	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
205922002965	NAD binding site [chemical binding]; other site
205922002966	dimerization interface [polypeptide binding]; other site
205922002967	product binding site; other site
205922002968	substrate binding site [chemical binding]; other site
205922002969	zinc binding site [ion binding]; other site
205922002970	catalytic residues [active]
205922002971	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
205922002972	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922002973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922002974	homodimer interface [polypeptide binding]; other site
205922002975	catalytic residue [active]
205922002976	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
205922002977	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922002978	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922002979	N-terminal plug; other site
205922002980	ligand-binding site [chemical binding]; other site
205922002981	serine endoprotease; Provisional; Region: PRK10898
205922002982	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
205922002983	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
205922002984	protein binding site [polypeptide binding]; other site
205922002985	Uncharacterized conserved protein [Function unknown]; Region: COG0327
205922002986	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
205922002987	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
205922002988	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
205922002989	Active Sites [active]
205922002990	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
205922002991	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
205922002992	CysD dimerization site [polypeptide binding]; other site
205922002993	G1 box; other site
205922002994	putative GEF interaction site [polypeptide binding]; other site
205922002995	GTP/Mg2+ binding site [chemical binding]; other site
205922002996	Switch I region; other site
205922002997	G2 box; other site
205922002998	G3 box; other site
205922002999	Switch II region; other site
205922003000	G4 box; other site
205922003001	G5 box; other site
205922003002	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
205922003003	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
205922003004	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
205922003005	ligand-binding site [chemical binding]; other site
205922003006	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922003007	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
205922003008	putative acyl-acceptor binding pocket; other site
205922003009	phosphate acetyltransferase; Reviewed; Region: PRK05632
205922003010	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922003011	DRTGG domain; Region: DRTGG; pfam07085
205922003012	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
205922003013	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
205922003014	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
205922003015	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205922003016	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
205922003017	catalytic residues [active]
205922003018	dimer interface [polypeptide binding]; other site
205922003019	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922003020	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
205922003021	putative active site [active]
205922003022	putative FMN binding site [chemical binding]; other site
205922003023	putative substrate binding site [chemical binding]; other site
205922003024	putative catalytic residue [active]
205922003025	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922003026	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
205922003027	putative sulfate transport protein CysZ; Validated; Region: PRK04949
205922003028	thioredoxin reductase; Provisional; Region: PRK10262
205922003029	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922003030	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922003031	HopJ type III effector protein; Region: HopJ; pfam08888
205922003032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
205922003033	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245
205922003034	active site
205922003035	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
205922003036	GTP cyclohydrolase I; Provisional; Region: PLN03044
205922003037	homodecamer interface [polypeptide binding]; other site
205922003038	active site
205922003039	putative catalytic site residues [active]
205922003040	zinc binding site [ion binding]; other site
205922003041	GTP-CH-I/GFRP interaction surface; other site
205922003042	dihydromonapterin reductase; Provisional; Region: PRK06483
205922003043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922003044	NAD(P) binding site [chemical binding]; other site
205922003045	active site
205922003046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
205922003047	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205922003048	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
205922003049	DNA binding residues [nucleotide binding]
205922003050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922003051	PAS domain; Region: PAS_9; pfam13426
205922003052	putative active site [active]
205922003053	heme pocket [chemical binding]; other site
205922003054	flavodoxin; Provisional; Region: PRK05723
205922003055	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922003056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922003058	dimerization interface [polypeptide binding]; other site
205922003059	LrgA family; Region: LrgA; pfam03788
205922003060	LrgB-like family; Region: LrgB; pfam04172
205922003061	aldolase II superfamily protein; Provisional; Region: PRK07044
205922003062	intersubunit interface [polypeptide binding]; other site
205922003063	active site
205922003064	Zn2+ binding site [ion binding]; other site
205922003065	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922003066	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
205922003067	homodimer interface [polypeptide binding]; other site
205922003068	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
205922003069	NAD binding site [chemical binding]; other site
205922003070	active site
205922003071	S-type Pyocin; Region: Pyocin_S; pfam06958
205922003072	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205922003073	active site
205922003074	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
205922003075	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
205922003076	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
205922003077	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922003078	DNA binding residues [nucleotide binding]
205922003079	dimerization interface [polypeptide binding]; other site
205922003080	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
205922003081	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922003082	Bacterial transcriptional regulator; Region: IclR; pfam01614
205922003083	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
205922003084	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
205922003085	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
205922003086	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
205922003087	maleylacetoacetate isomerase; Region: maiA; TIGR01262
205922003088	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
205922003089	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
205922003090	dimer interface [polypeptide binding]; other site
205922003091	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
205922003092	N-terminal domain interface [polypeptide binding]; other site
205922003093	benzoate transport; Region: 2A0115; TIGR00895
205922003094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922003095	putative substrate translocation pore; other site
205922003096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922003097	Uncharacterized conserved protein [Function unknown]; Region: COG2912
205922003098	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
205922003099	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
205922003100	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
205922003101	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
205922003102	NAD binding site [chemical binding]; other site
205922003103	Phe binding site; other site
205922003104	YebG protein; Region: YebG; pfam07130
205922003105	Predicted membrane protein [Function unknown]; Region: COG3223
205922003106	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
205922003107	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
205922003108	serine transporter; Region: stp; TIGR00814
205922003109	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
205922003110	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
205922003111	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
205922003112	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922003113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003114	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
205922003115	dimerization interface [polypeptide binding]; other site
205922003116	substrate binding pocket [chemical binding]; other site
205922003117	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
205922003118	30S subunit binding site; other site
205922003119	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
205922003120	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922003121	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922003122	N-terminal plug; other site
205922003123	ligand-binding site [chemical binding]; other site
205922003124	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922003125	FecR protein; Region: FecR; pfam04773
205922003126	RNA polymerase sigma factor; Provisional; Region: PRK12528
205922003127	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922003128	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922003129	DNA binding residues [nucleotide binding]
205922003130	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
205922003131	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
205922003132	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
205922003133	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
205922003134	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
205922003135	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922003136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922003137	DNA binding residues [nucleotide binding]
205922003138	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922003139	FecR protein; Region: FecR; pfam04773
205922003140	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922003141	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922003142	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922003143	N-terminal plug; other site
205922003144	ligand-binding site [chemical binding]; other site
205922003145	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922003146	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922003147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922003148	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
205922003149	EamA-like transporter family; Region: EamA; cl17759
205922003150	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
205922003151	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
205922003152	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
205922003153	dimerization interface [polypeptide binding]; other site
205922003154	ligand binding site [chemical binding]; other site
205922003155	NADP binding site [chemical binding]; other site
205922003156	catalytic site [active]
205922003157	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922003158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003159	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922003160	putative effector binding pocket; other site
205922003161	dimerization interface [polypeptide binding]; other site
205922003162	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922003163	Fusaric acid resistance protein family; Region: FUSC; pfam04632
205922003164	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
205922003165	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
205922003166	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
205922003167	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922003168	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922003169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
205922003170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922003171	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922003172	putative substrate translocation pore; other site
205922003173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922003174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922003175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003176	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922003177	putative effector binding pocket; other site
205922003178	dimerization interface [polypeptide binding]; other site
205922003179	short chain dehydrogenase; Provisional; Region: PRK05693
205922003180	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
205922003181	NADP binding site [chemical binding]; other site
205922003182	active site
205922003183	steroid binding site; other site
205922003184	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922003185	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922003186	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922003187	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922003188	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
205922003189	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
205922003190	Substrate binding site; other site
205922003191	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
205922003192	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
205922003193	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
205922003194	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244
205922003195	active site
205922003196	Right handed beta helix region; Region: Beta_helix; pfam13229
205922003197	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
205922003198	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922003199	PilZ domain; Region: PilZ; pfam07238
205922003200	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922003201	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922003202	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
205922003203	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
205922003204	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
205922003205	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
205922003206	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
205922003207	hypothetical protein; Validated; Region: PRK02101
205922003208	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
205922003209	NodB motif; other site
205922003210	active site
205922003211	catalytic site [active]
205922003212	metal binding site [ion binding]; metal-binding site
205922003213	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
205922003214	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
205922003215	putative active site [active]
205922003216	PhoH-like protein; Region: PhoH; pfam02562
205922003217	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
205922003218	trimer interface [polypeptide binding]; other site
205922003219	dimer interface [polypeptide binding]; other site
205922003220	putative active site [active]
205922003221	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
205922003222	MoaE interaction surface [polypeptide binding]; other site
205922003223	MoeB interaction surface [polypeptide binding]; other site
205922003224	thiocarboxylated glycine; other site
205922003225	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
205922003226	MoaE homodimer interface [polypeptide binding]; other site
205922003227	MoaD interaction [polypeptide binding]; other site
205922003228	active site residues [active]
205922003229	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
205922003230	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922003231	substrate binding pocket [chemical binding]; other site
205922003232	membrane-bound complex binding site; other site
205922003233	hinge residues; other site
205922003234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
205922003235	YheO-like PAS domain; Region: PAS_6; pfam08348
205922003236	HTH domain; Region: HTH_22; pfam13309
205922003237	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922003238	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922003239	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
205922003240	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
205922003241	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297
205922003242	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205922003243	ATP binding site [chemical binding]; other site
205922003244	Mg++ binding site [ion binding]; other site
205922003245	motif III; other site
205922003246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922003247	nucleotide binding region [chemical binding]; other site
205922003248	ATP-binding site [chemical binding]; other site
205922003249	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
205922003250	putative hydrolase; Provisional; Region: PRK11460
205922003251	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
205922003252	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922003253	substrate binding pocket [chemical binding]; other site
205922003254	membrane-bound complex binding site; other site
205922003255	hinge residues; other site
205922003256	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
205922003257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922003258	conserved gate region; other site
205922003259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922003260	dimer interface [polypeptide binding]; other site
205922003261	ABC-ATPase subunit interface; other site
205922003262	putative PBP binding loops; other site
205922003263	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922003264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922003265	dimer interface [polypeptide binding]; other site
205922003266	conserved gate region; other site
205922003267	putative PBP binding loops; other site
205922003268	ABC-ATPase subunit interface; other site
205922003269	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922003270	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922003271	Walker A/P-loop; other site
205922003272	ATP binding site [chemical binding]; other site
205922003273	Q-loop/lid; other site
205922003274	ABC transporter signature motif; other site
205922003275	Walker B; other site
205922003276	D-loop; other site
205922003277	H-loop/switch region; other site
205922003278	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922003279	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922003280	DNA-binding site [nucleotide binding]; DNA binding site
205922003281	FCD domain; Region: FCD; pfam07729
205922003282	cyanate transporter; Region: CynX; TIGR00896
205922003283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922003284	SnoaL-like domain; Region: SnoaL_3; pfam13474
205922003285	SnoaL-like domain; Region: SnoaL_2; pfam12680
205922003286	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
205922003287	GIY-YIG motif/motif A; other site
205922003288	putative active site [active]
205922003289	putative metal binding site [ion binding]; other site
205922003290	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922003291	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
205922003292	C-terminal domain interface [polypeptide binding]; other site
205922003293	GSH binding site (G-site) [chemical binding]; other site
205922003294	dimer interface [polypeptide binding]; other site
205922003295	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
205922003296	N-terminal domain interface [polypeptide binding]; other site
205922003297	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
205922003298	catalytic residues [active]
205922003299	Nucleoid-associated protein [General function prediction only]; Region: COG3081
205922003300	nucleoid-associated protein NdpA; Validated; Region: PRK00378
205922003301	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
205922003302	IHF dimer interface [polypeptide binding]; other site
205922003303	IHF - DNA interface [nucleotide binding]; other site
205922003304	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
205922003305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922003306	S-adenosylmethionine binding site [chemical binding]; other site
205922003307	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
205922003308	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
205922003309	HIGH motif; other site
205922003310	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
205922003311	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
205922003312	active site
205922003313	KMSKS motif; other site
205922003314	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
205922003315	tRNA binding surface [nucleotide binding]; other site
205922003316	anticodon binding site; other site
205922003317	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
205922003318	DNA polymerase III subunit chi; Validated; Region: PRK05728
205922003319	multifunctional aminopeptidase A; Provisional; Region: PRK00913
205922003320	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
205922003321	interface (dimer of trimers) [polypeptide binding]; other site
205922003322	Substrate-binding/catalytic site; other site
205922003323	Zn-binding sites [ion binding]; other site
205922003324	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
205922003325	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
205922003326	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
205922003327	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
205922003328	GTP-binding protein LepA; Provisional; Region: PRK05433
205922003329	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
205922003330	G1 box; other site
205922003331	putative GEF interaction site [polypeptide binding]; other site
205922003332	GTP/Mg2+ binding site [chemical binding]; other site
205922003333	Switch I region; other site
205922003334	G2 box; other site
205922003335	G3 box; other site
205922003336	Switch II region; other site
205922003337	G4 box; other site
205922003338	G5 box; other site
205922003339	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
205922003340	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
205922003341	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
205922003342	signal peptidase I; Provisional; Region: PRK10861
205922003343	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
205922003344	Catalytic site [active]
205922003345	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
205922003346	ribonuclease III; Reviewed; Region: rnc; PRK00102
205922003347	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
205922003348	dimerization interface [polypeptide binding]; other site
205922003349	active site
205922003350	metal binding site [ion binding]; metal-binding site
205922003351	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
205922003352	dsRNA binding site [nucleotide binding]; other site
205922003353	GTPase Era; Reviewed; Region: era; PRK00089
205922003354	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
205922003355	G1 box; other site
205922003356	GTP/Mg2+ binding site [chemical binding]; other site
205922003357	Switch I region; other site
205922003358	G2 box; other site
205922003359	Switch II region; other site
205922003360	G3 box; other site
205922003361	G4 box; other site
205922003362	G5 box; other site
205922003363	KH domain; Region: KH_2; pfam07650
205922003364	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
205922003365	Recombination protein O N terminal; Region: RecO_N; pfam11967
205922003366	Recombination protein O C terminal; Region: RecO_C; pfam02565
205922003367	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
205922003368	active site
205922003369	hydrophilic channel; other site
205922003370	dimerization interface [polypeptide binding]; other site
205922003371	catalytic residues [active]
205922003372	active site lid [active]
205922003373	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
205922003374	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922003375	substrate binding pocket [chemical binding]; other site
205922003376	membrane-bound complex binding site; other site
205922003377	hinge residues; other site
205922003378	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922003379	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922003380	catalytic residue [active]
205922003381	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
205922003382	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
205922003383	dimerization interface [polypeptide binding]; other site
205922003384	ATP binding site [chemical binding]; other site
205922003385	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
205922003386	dimerization interface [polypeptide binding]; other site
205922003387	ATP binding site [chemical binding]; other site
205922003388	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
205922003389	putative active site [active]
205922003390	catalytic triad [active]
205922003391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
205922003392	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
205922003393	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
205922003394	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
205922003395	active site turn [active]
205922003396	phosphorylation site [posttranslational modification]
205922003397	phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367
205922003398	active site turn [active]
205922003399	phosphorylation site [posttranslational modification]
205922003400	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
205922003401	HPr interaction site; other site
205922003402	glycerol kinase (GK) interaction site [polypeptide binding]; other site
205922003403	active site
205922003404	phosphorylation site [posttranslational modification]
205922003405	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
205922003406	dimerization domain swap beta strand [polypeptide binding]; other site
205922003407	regulatory protein interface [polypeptide binding]; other site
205922003408	active site
205922003409	regulatory phosphorylation site [posttranslational modification]; other site
205922003410	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
205922003411	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
205922003412	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205922003413	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
205922003414	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
205922003415	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
205922003416	dimer interface [polypeptide binding]; other site
205922003417	active site
205922003418	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
205922003419	dimer interface [polypeptide binding]; other site
205922003420	active site
205922003421	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
205922003422	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
205922003423	active site
205922003424	dimer interface [polypeptide binding]; other site
205922003425	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205922003426	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922003427	DNA-binding site [nucleotide binding]; DNA binding site
205922003428	UTRA domain; Region: UTRA; pfam07702
205922003429	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
205922003430	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
205922003431	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
205922003432	nudix motif; other site
205922003433	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
205922003434	putative active site [active]
205922003435	putative CoA binding site [chemical binding]; other site
205922003436	nudix motif; other site
205922003437	metal binding site [ion binding]; metal-binding site
205922003438	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
205922003439	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
205922003440	trimer interface [polypeptide binding]; other site
205922003441	putative metal binding site [ion binding]; other site
205922003442	Predicted Fe-S protein [General function prediction only]; Region: COG3313
205922003443	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
205922003444	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
205922003445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922003446	ATP-grasp domain; Region: ATP-grasp; pfam02222
205922003447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922003448	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922003449	putative substrate translocation pore; other site
205922003450	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
205922003451	Domain of unknown function DUF21; Region: DUF21; pfam01595
205922003452	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
205922003453	Transporter associated domain; Region: CorC_HlyC; smart01091
205922003454	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
205922003455	signal recognition particle protein; Provisional; Region: PRK10867
205922003456	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
205922003457	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
205922003458	P loop; other site
205922003459	GTP binding site [chemical binding]; other site
205922003460	Signal peptide binding domain; Region: SRP_SPB; pfam02978
205922003461	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
205922003462	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
205922003463	RimM N-terminal domain; Region: RimM; pfam01782
205922003464	PRC-barrel domain; Region: PRC; pfam05239
205922003465	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
205922003466	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
205922003467	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
205922003468	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
205922003469	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
205922003470	TrkA-N domain; Region: TrkA_N; pfam02254
205922003471	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
205922003472	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
205922003473	active site
205922003474	Int/Topo IB signature motif; other site
205922003475	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
205922003476	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
205922003477	dimerization domain [polypeptide binding]; other site
205922003478	dimer interface [polypeptide binding]; other site
205922003479	catalytic residues [active]
205922003480	homoserine dehydrogenase; Provisional; Region: PRK06349
205922003481	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
205922003482	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
205922003483	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
205922003484	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
205922003485	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
205922003486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922003487	catalytic residue [active]
205922003488	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922003489	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922003490	substrate binding pocket [chemical binding]; other site
205922003491	membrane-bound complex binding site; other site
205922003492	hinge residues; other site
205922003493	PAS fold; Region: PAS; pfam00989
205922003494	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922003495	putative active site [active]
205922003496	heme pocket [chemical binding]; other site
205922003497	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
205922003498	conserved hypothetical protein; Region: TIGR02285
205922003499	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
205922003500	CoA-transferase family III; Region: CoA_transf_3; pfam02515
205922003501	YaeQ protein; Region: YaeQ; pfam07152
205922003502	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
205922003503	DHH family; Region: DHH; pfam01368
205922003504	DHHA1 domain; Region: DHHA1; pfam02272
205922003505	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922003506	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
205922003507	active site
205922003508	FMN binding site [chemical binding]; other site
205922003509	substrate binding site [chemical binding]; other site
205922003510	homotetramer interface [polypeptide binding]; other site
205922003511	catalytic residue [active]
205922003512	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
205922003513	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
205922003514	BRO family, N-terminal domain; Region: Bro-N; smart01040
205922003515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922003516	AAA domain; Region: AAA_21; pfam13304
205922003517	Walker A/P-loop; other site
205922003518	ATP binding site [chemical binding]; other site
205922003519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922003520	Walker B; other site
205922003521	D-loop; other site
205922003522	H-loop/switch region; other site
205922003523	RloB-like protein; Region: RloB; pfam13707
205922003524	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
205922003525	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
205922003526	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
205922003527	tetrameric interface [polypeptide binding]; other site
205922003528	NAD binding site [chemical binding]; other site
205922003529	catalytic residues [active]
205922003530	substrate binding site [chemical binding]; other site
205922003531	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922003532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922003533	dimer interface [polypeptide binding]; other site
205922003534	conserved gate region; other site
205922003535	ABC-ATPase subunit interface; other site
205922003536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922003537	dimer interface [polypeptide binding]; other site
205922003538	putative PBP binding loops; other site
205922003539	ABC-ATPase subunit interface; other site
205922003540	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922003541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922003542	Walker A/P-loop; other site
205922003543	ATP binding site [chemical binding]; other site
205922003544	Q-loop/lid; other site
205922003545	ABC transporter signature motif; other site
205922003546	Walker B; other site
205922003547	D-loop; other site
205922003548	H-loop/switch region; other site
205922003549	TOBE domain; Region: TOBE_2; pfam08402
205922003550	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
205922003551	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922003552	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
205922003553	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
205922003554	tetrameric interface [polypeptide binding]; other site
205922003555	NAD binding site [chemical binding]; other site
205922003556	catalytic residues [active]
205922003557	substrate binding site [chemical binding]; other site
205922003558	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922003559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003560	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
205922003561	putative substrate binding pocket [chemical binding]; other site
205922003562	dimerization interface [polypeptide binding]; other site
205922003563	Protein of unknown function (DUF533); Region: DUF533; pfam04391
205922003564	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
205922003565	putative metal binding site [ion binding]; other site
205922003566	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922003567	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922003568	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922003569	dimerization interface [polypeptide binding]; other site
205922003570	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922003571	dimer interface [polypeptide binding]; other site
205922003572	putative CheW interface [polypeptide binding]; other site
205922003573	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
205922003574	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
205922003575	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
205922003576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922003577	S-adenosylmethionine binding site [chemical binding]; other site
205922003578	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
205922003579	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922003580	putative binding surface; other site
205922003581	active site
205922003582	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
205922003583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922003584	ATP binding site [chemical binding]; other site
205922003585	Mg2+ binding site [ion binding]; other site
205922003586	G-X-G motif; other site
205922003587	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
205922003588	Response regulator receiver domain; Region: Response_reg; pfam00072
205922003589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922003590	active site
205922003591	phosphorylation site [posttranslational modification]
205922003592	intermolecular recognition site; other site
205922003593	dimerization interface [polypeptide binding]; other site
205922003594	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
205922003595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922003596	active site
205922003597	phosphorylation site [posttranslational modification]
205922003598	intermolecular recognition site; other site
205922003599	CheB methylesterase; Region: CheB_methylest; pfam01339
205922003600	Response regulator receiver domain; Region: Response_reg; pfam00072
205922003601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922003602	active site
205922003603	phosphorylation site [posttranslational modification]
205922003604	intermolecular recognition site; other site
205922003605	dimerization interface [polypeptide binding]; other site
205922003606	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922003607	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922003608	metal binding site [ion binding]; metal-binding site
205922003609	active site
205922003610	I-site; other site
205922003611	This domain is found in peptide chain release factors; Region: PCRF; smart00937
205922003612	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
205922003613	RF-1 domain; Region: RF-1; pfam00472
205922003614	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
205922003615	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
205922003616	dimer interface [polypeptide binding]; other site
205922003617	putative anticodon binding site; other site
205922003618	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
205922003619	motif 1; other site
205922003620	active site
205922003621	motif 2; other site
205922003622	motif 3; other site
205922003623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
205922003624	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
205922003625	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922003626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922003627	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922003628	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922003629	ligand binding site [chemical binding]; other site
205922003630	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
205922003631	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
205922003632	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
205922003633	adenylate kinase; Reviewed; Region: adk; PRK00279
205922003634	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
205922003635	AMP-binding site [chemical binding]; other site
205922003636	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
205922003637	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
205922003638	Glycoprotease family; Region: Peptidase_M22; pfam00814
205922003639	Protein of unknown function DUF72; Region: DUF72; cl00777
205922003640	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
205922003641	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
205922003642	tetramer interface [polypeptide binding]; other site
205922003643	active site
205922003644	Mg2+/Mn2+ binding site [ion binding]; other site
205922003645	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
205922003646	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
205922003647	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922003648	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922003649	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
205922003650	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922003651	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922003652	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922003653	putative membrane fusion protein; Region: TIGR02828
205922003654	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
205922003655	Fic family protein [Function unknown]; Region: COG3177
205922003656	Fic/DOC family; Region: Fic; pfam02661
205922003657	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
205922003658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
205922003659	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
205922003660	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
205922003661	putative acyl-acceptor binding pocket; other site
205922003662	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205922003663	DNA-binding site [nucleotide binding]; DNA binding site
205922003664	RNA-binding motif; other site
205922003665	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
205922003666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922003667	S-adenosylmethionine binding site [chemical binding]; other site
205922003668	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
205922003669	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
205922003670	metal binding site [ion binding]; metal-binding site
205922003671	dimer interface [polypeptide binding]; other site
205922003672	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
205922003673	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922003674	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
205922003675	Ligand binding site; other site
205922003676	DXD motif; other site
205922003677	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
205922003678	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
205922003679	putative ATP binding site [chemical binding]; other site
205922003680	putative substrate interface [chemical binding]; other site
205922003681	Fe-S metabolism associated domain; Region: SufE; cl00951
205922003682	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
205922003683	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
205922003684	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922003685	catalytic residue [active]
205922003686	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
205922003687	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
205922003688	putative trimer interface [polypeptide binding]; other site
205922003689	putative CoA binding site [chemical binding]; other site
205922003690	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
205922003691	ArsC family; Region: ArsC; pfam03960
205922003692	putative catalytic residues [active]
205922003693	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
205922003694	Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327
205922003695	active site
205922003696	Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327
205922003697	active site
205922003698	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
205922003699	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922003700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922003701	homodimer interface [polypeptide binding]; other site
205922003702	catalytic residue [active]
205922003703	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
205922003704	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
205922003705	metal binding triad; other site
205922003706	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
205922003707	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922003708	Zn2+ binding site [ion binding]; other site
205922003709	Mg2+ binding site [ion binding]; other site
205922003710	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
205922003711	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
205922003712	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
205922003713	active site
205922003714	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
205922003715	rRNA interaction site [nucleotide binding]; other site
205922003716	S8 interaction site; other site
205922003717	putative laminin-1 binding site; other site
205922003718	elongation factor Ts; Provisional; Region: tsf; PRK09377
205922003719	UBA/TS-N domain; Region: UBA; pfam00627
205922003720	Elongation factor TS; Region: EF_TS; pfam00889
205922003721	Elongation factor TS; Region: EF_TS; pfam00889
205922003722	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
205922003723	putative nucleotide binding site [chemical binding]; other site
205922003724	uridine monophosphate binding site [chemical binding]; other site
205922003725	homohexameric interface [polypeptide binding]; other site
205922003726	ribosome recycling factor; Reviewed; Region: frr; PRK00083
205922003727	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
205922003728	hinge region; other site
205922003729	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
205922003730	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
205922003731	catalytic residue [active]
205922003732	putative FPP diphosphate  binding site; other site
205922003733	putative FPP binding hydrophobic cleft; other site
205922003734	dimer interface [polypeptide binding]; other site
205922003735	putative IPP diphosphate binding site; other site
205922003736	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
205922003737	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
205922003738	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
205922003739	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
205922003740	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
205922003741	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
205922003742	zinc metallopeptidase RseP; Provisional; Region: PRK10779
205922003743	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
205922003744	active site
205922003745	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
205922003746	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
205922003747	protein binding site [polypeptide binding]; other site
205922003748	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
205922003749	putative substrate binding region [chemical binding]; other site
205922003750	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
205922003751	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
205922003752	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
205922003753	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
205922003754	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
205922003755	Surface antigen; Region: Bac_surface_Ag; pfam01103
205922003756	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
205922003757	periplasmic chaperone; Provisional; Region: PRK10780
205922003758	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
205922003759	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
205922003760	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
205922003761	trimer interface [polypeptide binding]; other site
205922003762	active site
205922003763	UDP-GlcNAc binding site [chemical binding]; other site
205922003764	lipid binding site [chemical binding]; lipid-binding site
205922003765	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
205922003766	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
205922003767	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
205922003768	active site
205922003769	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
205922003770	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
205922003771	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
205922003772	RNA/DNA hybrid binding site [nucleotide binding]; other site
205922003773	active site
205922003774	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
205922003775	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
205922003776	putative active site [active]
205922003777	putative PHP Thumb interface [polypeptide binding]; other site
205922003778	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
205922003779	generic binding surface II; other site
205922003780	generic binding surface I; other site
205922003781	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
205922003782	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
205922003783	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
205922003784	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
205922003785	Ligand Binding Site [chemical binding]; other site
205922003786	TilS substrate binding domain; Region: TilS; pfam09179
205922003787	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
205922003788	CTP synthetase; Validated; Region: pyrG; PRK05380
205922003789	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
205922003790	Catalytic site [active]
205922003791	active site
205922003792	UTP binding site [chemical binding]; other site
205922003793	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
205922003794	active site
205922003795	putative oxyanion hole; other site
205922003796	catalytic triad [active]
205922003797	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
205922003798	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
205922003799	enolase; Provisional; Region: eno; PRK00077
205922003800	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
205922003801	dimer interface [polypeptide binding]; other site
205922003802	metal binding site [ion binding]; metal-binding site
205922003803	substrate binding pocket [chemical binding]; other site
205922003804	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
205922003805	Septum formation initiator; Region: DivIC; cl17659
205922003806	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
205922003807	substrate binding site; other site
205922003808	dimer interface; other site
205922003809	LysR family transcriptional regulator; Provisional; Region: PRK14997
205922003810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003811	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
205922003812	putative effector binding pocket; other site
205922003813	putative dimerization interface [polypeptide binding]; other site
205922003814	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
205922003815	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
205922003816	substrate binding site [chemical binding]; other site
205922003817	catalytic Zn binding site [ion binding]; other site
205922003818	NAD binding site [chemical binding]; other site
205922003819	structural Zn binding site [ion binding]; other site
205922003820	dimer interface [polypeptide binding]; other site
205922003821	S-formylglutathione hydrolase; Region: PLN02442
205922003822	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
205922003823	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
205922003824	homotrimer interaction site [polypeptide binding]; other site
205922003825	zinc binding site [ion binding]; other site
205922003826	CDP-binding sites; other site
205922003827	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
205922003828	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
205922003829	Permutation of conserved domain; other site
205922003830	active site
205922003831	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
205922003832	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
205922003833	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
205922003834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922003835	S-adenosylmethionine binding site [chemical binding]; other site
205922003836	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922003837	Peptidase family M23; Region: Peptidase_M23; pfam01551
205922003838	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
205922003839	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
205922003840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922003841	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
205922003842	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922003843	DNA binding residues [nucleotide binding]
205922003844	Ferredoxin [Energy production and conversion]; Region: COG1146
205922003845	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
205922003846	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
205922003847	MutS domain I; Region: MutS_I; pfam01624
205922003848	MutS domain II; Region: MutS_II; pfam05188
205922003849	MutS domain III; Region: MutS_III; pfam05192
205922003850	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
205922003851	Walker A/P-loop; other site
205922003852	ATP binding site [chemical binding]; other site
205922003853	Q-loop/lid; other site
205922003854	ABC transporter signature motif; other site
205922003855	Walker B; other site
205922003856	D-loop; other site
205922003857	H-loop/switch region; other site
205922003858	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205922003859	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922003860	non-specific DNA binding site [nucleotide binding]; other site
205922003861	salt bridge; other site
205922003862	sequence-specific DNA binding site [nucleotide binding]; other site
205922003863	Predicted transcriptional regulator [Transcription]; Region: COG2932
205922003864	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
205922003865	Catalytic site [active]
205922003866	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
205922003867	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
205922003868	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922003869	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
205922003870	Baseplate J-like protein; Region: Baseplate_J; cl01294
205922003871	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
205922003872	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
205922003873	Phage Tail Collar Domain; Region: Collar; pfam07484
205922003874	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
205922003875	Phage Tail Collar Domain; Region: Collar; pfam07484
205922003876	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
205922003877	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
205922003878	Phage tail tube protein FII; Region: Phage_tube; pfam04985
205922003879	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
205922003880	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
205922003881	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
205922003882	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
205922003883	Phage Tail Protein X; Region: Phage_tail_X; cl02088
205922003884	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
205922003885	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
205922003886	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
205922003887	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
205922003888	Phage tail tube protein; Region: Tail_tube; pfam10618
205922003889	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
205922003890	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
205922003891	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
205922003892	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
205922003893	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922003894	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
205922003895	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
205922003896	Phage protein GP46; Region: GP46; pfam07409
205922003897	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
205922003898	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
205922003899	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
205922003900	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
205922003901	Predicted chitinase [General function prediction only]; Region: COG3179
205922003902	catalytic residue [active]
205922003903	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
205922003904	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
205922003905	recombinase A; Provisional; Region: recA; PRK09354
205922003906	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
205922003907	hexamer interface [polypeptide binding]; other site
205922003908	Walker A motif; other site
205922003909	ATP binding site [chemical binding]; other site
205922003910	Walker B motif; other site
205922003911	recombination regulator RecX; Reviewed; Region: recX; PRK00117
205922003912	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
205922003913	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
205922003914	Uncharacterized conserved protein [Function unknown]; Region: COG3148
205922003915	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922003916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922003917	active site
205922003918	phosphorylation site [posttranslational modification]
205922003919	intermolecular recognition site; other site
205922003920	dimerization interface [polypeptide binding]; other site
205922003921	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922003922	DNA binding residues [nucleotide binding]
205922003923	dimerization interface [polypeptide binding]; other site
205922003924	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
205922003925	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
205922003926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922003927	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
205922003928	putative dimerization interface [polypeptide binding]; other site
205922003929	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
205922003930	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
205922003931	FAD binding pocket [chemical binding]; other site
205922003932	FAD binding motif [chemical binding]; other site
205922003933	phosphate binding motif [ion binding]; other site
205922003934	beta-alpha-beta structure motif; other site
205922003935	NAD binding pocket [chemical binding]; other site
205922003936	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
205922003937	homodimer interaction site [polypeptide binding]; other site
205922003938	cofactor binding site; other site
205922003939	RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942
205922003940	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
205922003941	NADP binding site [chemical binding]; other site
205922003942	active site
205922003943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
205922003944	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
205922003945	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
205922003946	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
205922003947	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922003948	RNA binding surface [nucleotide binding]; other site
205922003949	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
205922003950	active site
205922003951	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922003952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922003953	Coenzyme A binding pocket [chemical binding]; other site
205922003954	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
205922003955	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
205922003956	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922003957	FeS/SAM binding site; other site
205922003958	TRAM domain; Region: TRAM; cl01282
205922003959	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
205922003960	potassium uptake protein; Region: kup; TIGR00794
205922003961	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
205922003962	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
205922003963	Predicted integral membrane protein [Function unknown]; Region: COG0392
205922003964	Uncharacterized conserved protein [Function unknown]; Region: COG2898
205922003965	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
205922003966	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
205922003967	active site
205922003968	DNA polymerase IV; Validated; Region: PRK02406
205922003969	DNA binding site [nucleotide binding]
205922003970	prolyl-tRNA synthetase; Provisional; Region: PRK09194
205922003971	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
205922003972	dimer interface [polypeptide binding]; other site
205922003973	motif 1; other site
205922003974	active site
205922003975	motif 2; other site
205922003976	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
205922003977	putative deacylase active site [active]
205922003978	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
205922003979	active site
205922003980	motif 3; other site
205922003981	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
205922003982	anticodon binding site; other site
205922003983	muropeptide transporter; Validated; Region: ampG; cl17669
205922003984	muropeptide transporter; Validated; Region: ampG; cl17669
205922003985	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
205922003986	DNA binding site [nucleotide binding]
205922003987	active site
205922003988	Protein of unknown function, DUF481; Region: DUF481; pfam04338
205922003989	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205922003990	DNA-binding site [nucleotide binding]; DNA binding site
205922003991	RNA-binding motif; other site
205922003992	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
205922003993	trimer interface [polypeptide binding]; other site
205922003994	active site
205922003995	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
205922003996	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
205922003997	putative active site [active]
205922003998	putative metal binding site [ion binding]; other site
205922003999	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
205922004000	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922004001	ATP binding site [chemical binding]; other site
205922004002	putative Mg++ binding site [ion binding]; other site
205922004003	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922004004	nucleotide binding region [chemical binding]; other site
205922004005	ATP-binding site [chemical binding]; other site
205922004006	DEAD/H associated; Region: DEAD_assoc; pfam08494
205922004007	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
205922004008	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922004009	Walker A/P-loop; other site
205922004010	ATP binding site [chemical binding]; other site
205922004011	Q-loop/lid; other site
205922004012	ABC transporter signature motif; other site
205922004013	Walker B; other site
205922004014	D-loop; other site
205922004015	H-loop/switch region; other site
205922004016	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
205922004017	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
205922004018	active site
205922004019	Zn binding site [ion binding]; other site
205922004020	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922004021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922004022	dimer interface [polypeptide binding]; other site
205922004023	conserved gate region; other site
205922004024	putative PBP binding loops; other site
205922004025	ABC-ATPase subunit interface; other site
205922004026	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922004027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922004028	dimer interface [polypeptide binding]; other site
205922004029	conserved gate region; other site
205922004030	putative PBP binding loops; other site
205922004031	ABC-ATPase subunit interface; other site
205922004032	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
205922004033	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922004034	substrate binding pocket [chemical binding]; other site
205922004035	membrane-bound complex binding site; other site
205922004036	hinge residues; other site
205922004037	ATP-dependent DNA ligase; Validated; Region: PRK09247
205922004038	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
205922004039	active site
205922004040	DNA binding site [nucleotide binding]
205922004041	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
205922004042	DNA binding site [nucleotide binding]
205922004043	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
205922004044	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
205922004045	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
205922004046	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
205922004047	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
205922004048	active site
205922004049	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
205922004050	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
205922004051	C-terminal domain interface [polypeptide binding]; other site
205922004052	GSH binding site (G-site) [chemical binding]; other site
205922004053	dimer interface [polypeptide binding]; other site
205922004054	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
205922004055	N-terminal domain interface [polypeptide binding]; other site
205922004056	putative dimer interface [polypeptide binding]; other site
205922004057	active site
205922004058	Isochorismatase family; Region: Isochorismatase; pfam00857
205922004059	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
205922004060	catalytic triad [active]
205922004061	conserved cis-peptide bond; other site
205922004062	SEC-C motif; Region: SEC-C; pfam02810
205922004063	LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608
205922004064	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
205922004065	hypothetical protein; Provisional; Region: PRK00183
205922004066	SEC-C motif; Region: SEC-C; pfam02810
205922004067	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922004068	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922004069	ligand binding site [chemical binding]; other site
205922004070	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922004071	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922004072	ligand binding site [chemical binding]; other site
205922004073	Protein of unknown function (DUF1145); Region: DUF1145; cl11481
205922004074	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
205922004075	Predicted integral membrane protein [Function unknown]; Region: COG5615
205922004076	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
205922004077	DEAD/DEAH box helicase; Region: DEAD; pfam00270
205922004078	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
205922004079	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
205922004080	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
205922004081	Beta-lactamase; Region: Beta-lactamase; pfam00144
205922004082	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922004083	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922004084	ligand binding site [chemical binding]; other site
205922004085	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
205922004086	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
205922004087	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
205922004088	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
205922004089	EspA-like secreted protein; Region: EspA; cl04069
205922004090	S-type Pyocin; Region: Pyocin_S; pfam06958
205922004091	Cytotoxic; Region: Cytotoxic; pfam09000
205922004092	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
205922004093	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
205922004094	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
205922004095	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922004096	catalytic residue [active]
205922004097	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
205922004098	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922004099	Predicted membrane protein [Function unknown]; Region: COG3650
205922004100	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
205922004101	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
205922004102	putative NAD(P) binding site [chemical binding]; other site
205922004103	homodimer interface [polypeptide binding]; other site
205922004104	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004105	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004106	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922004107	putative effector binding pocket; other site
205922004108	dimerization interface [polypeptide binding]; other site
205922004109	Predicted membrane protein [Function unknown]; Region: COG2259
205922004110	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
205922004111	hypothetical protein; Provisional; Region: PRK05409
205922004112	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
205922004113	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
205922004114	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
205922004115	Walker A/P-loop; other site
205922004116	ATP binding site [chemical binding]; other site
205922004117	Q-loop/lid; other site
205922004118	ABC transporter signature motif; other site
205922004119	Walker B; other site
205922004120	D-loop; other site
205922004121	H-loop/switch region; other site
205922004122	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
205922004123	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
205922004124	Walker A/P-loop; other site
205922004125	ATP binding site [chemical binding]; other site
205922004126	Q-loop/lid; other site
205922004127	ABC transporter signature motif; other site
205922004128	Walker B; other site
205922004129	D-loop; other site
205922004130	H-loop/switch region; other site
205922004131	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
205922004132	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
205922004133	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
205922004134	TM-ABC transporter signature motif; other site
205922004135	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922004136	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
205922004137	TM-ABC transporter signature motif; other site
205922004138	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
205922004139	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
205922004140	dimerization interface [polypeptide binding]; other site
205922004141	ligand binding site [chemical binding]; other site
205922004142	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
205922004143	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
205922004144	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
205922004145	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
205922004146	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
205922004147	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
205922004148	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922004149	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922004150	metal binding site [ion binding]; metal-binding site
205922004151	active site
205922004152	I-site; other site
205922004153	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922004154	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
205922004155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004156	putative substrate translocation pore; other site
205922004157	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922004158	ATP-dependent helicase HepA; Validated; Region: PRK04914
205922004159	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922004160	ATP binding site [chemical binding]; other site
205922004161	putative Mg++ binding site [ion binding]; other site
205922004162	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922004163	nucleotide binding region [chemical binding]; other site
205922004164	ATP-binding site [chemical binding]; other site
205922004165	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
205922004166	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
205922004167	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922004168	catalytic residue [active]
205922004169	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
205922004170	homotrimer interaction site [polypeptide binding]; other site
205922004171	putative active site [active]
205922004172	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922004173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004174	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
205922004175	dimerization interface [polypeptide binding]; other site
205922004176	substrate binding pocket [chemical binding]; other site
205922004177	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
205922004178	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
205922004179	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
205922004180	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
205922004181	Bacterial transcriptional regulator; Region: IclR; pfam01614
205922004182	benzoate transport; Region: 2A0115; TIGR00895
205922004183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004184	putative substrate translocation pore; other site
205922004185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004186	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
205922004187	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
205922004188	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
205922004189	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922004190	dimer interface [polypeptide binding]; other site
205922004191	active site
205922004192	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
205922004193	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
205922004194	heterodimer interface [polypeptide binding]; other site
205922004195	multimer interface [polypeptide binding]; other site
205922004196	active site
205922004197	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
205922004198	heterodimer interface [polypeptide binding]; other site
205922004199	active site
205922004200	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
205922004201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004202	putative substrate translocation pore; other site
205922004203	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
205922004204	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
205922004205	tetramer interface [polypeptide binding]; other site
205922004206	active site
205922004207	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
205922004208	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
205922004209	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
205922004210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922004211	S-adenosylmethionine binding site [chemical binding]; other site
205922004212	outer membrane porin, OprD family; Region: OprD; pfam03573
205922004213	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922004214	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
205922004215	Protein export membrane protein; Region: SecD_SecF; cl14618
205922004216	Protein export membrane protein; Region: SecD_SecF; cl14618
205922004217	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922004218	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922004219	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922004220	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
205922004221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922004222	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
205922004223	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922004224	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
205922004225	FMN binding site [chemical binding]; other site
205922004226	active site
205922004227	substrate binding site [chemical binding]; other site
205922004228	catalytic residue [active]
205922004229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004230	putative substrate translocation pore; other site
205922004231	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922004232	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922004233	dimerization interface [polypeptide binding]; other site
205922004234	putative DNA binding site [nucleotide binding]; other site
205922004235	putative Zn2+ binding site [ion binding]; other site
205922004236	Protein of unknown function, DUF479; Region: DUF479; cl01203
205922004237	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922004238	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
205922004239	putative acyl-acceptor binding pocket; other site
205922004240	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
205922004241	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922004242	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922004243	Beta-lactamase; Region: Beta-lactamase; pfam00144
205922004244	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
205922004245	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
205922004246	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
205922004247	metal binding site [ion binding]; metal-binding site
205922004248	putative dimer interface [polypeptide binding]; other site
205922004249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004250	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922004251	putative substrate translocation pore; other site
205922004252	amidase; Provisional; Region: PRK07486
205922004253	Amidase; Region: Amidase; pfam01425
205922004254	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
205922004255	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922004256	YceI-like domain; Region: YceI; pfam04264
205922004257	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
205922004258	PLD-like domain; Region: PLDc_2; pfam13091
205922004259	putative active site [active]
205922004260	catalytic site [active]
205922004261	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
205922004262	PLD-like domain; Region: PLDc_2; pfam13091
205922004263	putative active site [active]
205922004264	catalytic site [active]
205922004265	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
205922004266	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
205922004267	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
205922004268	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
205922004269	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
205922004270	Repair protein; Region: Repair_PSII; pfam04536
205922004271	Repair protein; Region: Repair_PSII; cl01535
205922004272	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922004273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922004274	S-adenosylmethionine binding site [chemical binding]; other site
205922004275	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
205922004276	EamA-like transporter family; Region: EamA; cl17759
205922004277	EamA-like transporter family; Region: EamA; pfam00892
205922004278	intracellular protease, PfpI family; Region: PfpI; TIGR01382
205922004279	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
205922004280	conserved cys residue [active]
205922004281	Uncharacterized conserved protein [Function unknown]; Region: COG3422
205922004282	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
205922004283	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
205922004284	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
205922004285	inhibitor site; inhibition site
205922004286	active site
205922004287	dimer interface [polypeptide binding]; other site
205922004288	catalytic residue [active]
205922004289	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
205922004290	intersubunit interface [polypeptide binding]; other site
205922004291	active site
205922004292	Zn2+ binding site [ion binding]; other site
205922004293	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922004294	non-specific DNA binding site [nucleotide binding]; other site
205922004295	salt bridge; other site
205922004296	sequence-specific DNA binding site [nucleotide binding]; other site
205922004297	Cupin domain; Region: Cupin_2; pfam07883
205922004298	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
205922004299	putative alcohol dehydrogenase; Provisional; Region: PRK09860
205922004300	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
205922004301	dimer interface [polypeptide binding]; other site
205922004302	active site
205922004303	metal binding site [ion binding]; metal-binding site
205922004304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004305	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
205922004306	putative substrate translocation pore; other site
205922004307	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004308	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004309	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
205922004310	putative dimerization interface [polypeptide binding]; other site
205922004311	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
205922004312	CoA-transferase family III; Region: CoA_transf_3; pfam02515
205922004313	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
205922004314	active site
205922004315	catalytic residues [active]
205922004316	metal binding site [ion binding]; metal-binding site
205922004317	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
205922004318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004319	putative substrate translocation pore; other site
205922004320	Protein of unknown function, DUF606; Region: DUF606; pfam04657
205922004321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004323	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
205922004324	putative substrate binding pocket [chemical binding]; other site
205922004325	putative dimerization interface [polypeptide binding]; other site
205922004326	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
205922004327	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
205922004328	active site
205922004329	metal binding site [ion binding]; metal-binding site
205922004330	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922004331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922004332	PAS domain; Region: PAS_9; pfam13426
205922004333	putative active site [active]
205922004334	heme pocket [chemical binding]; other site
205922004335	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
205922004336	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
205922004337	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922004338	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922004339	metal binding site [ion binding]; metal-binding site
205922004340	active site
205922004341	I-site; other site
205922004342	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
205922004343	Low affinity iron permease; Region: Iron_permease; pfam04120
205922004344	Uncharacterized conserved protein [Function unknown]; Region: COG4748
205922004345	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
205922004346	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
205922004347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922004348	S-adenosylmethionine binding site [chemical binding]; other site
205922004349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922004350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922004351	S-adenosylmethionine binding site [chemical binding]; other site
205922004352	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
205922004353	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
205922004354	Zeta toxin; Region: Zeta_toxin; pfam06414
205922004355	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922004356	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
205922004357	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922004358	RNA binding surface [nucleotide binding]; other site
205922004359	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
205922004360	active site
205922004361	uracil binding [chemical binding]; other site
205922004362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922004363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922004364	metal binding site [ion binding]; metal-binding site
205922004365	active site
205922004366	I-site; other site
205922004367	allophanate hydrolase; Provisional; Region: PRK08186
205922004368	Amidase; Region: Amidase; cl11426
205922004369	urea carboxylase; Region: urea_carbox; TIGR02712
205922004370	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922004371	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205922004372	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
205922004373	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
205922004374	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
205922004375	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922004376	carboxyltransferase (CT) interaction site; other site
205922004377	biotinylation site [posttranslational modification]; other site
205922004378	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
205922004379	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
205922004380	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
205922004381	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
205922004382	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
205922004383	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922004384	Walker A/P-loop; other site
205922004385	ATP binding site [chemical binding]; other site
205922004386	Q-loop/lid; other site
205922004387	ABC transporter signature motif; other site
205922004388	Walker B; other site
205922004389	D-loop; other site
205922004390	H-loop/switch region; other site
205922004391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
205922004392	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
205922004393	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
205922004394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
205922004395	putative transposase OrfB; Reviewed; Region: PHA02517
205922004396	Integrase core domain; Region: rve; pfam00665
205922004397	Integrase core domain; Region: rve_3; pfam13683
205922004398	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
205922004399	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922004400	substrate binding site [chemical binding]; other site
205922004401	oxyanion hole (OAH) forming residues; other site
205922004402	trimer interface [polypeptide binding]; other site
205922004403	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
205922004404	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
205922004405	ligand binding site [chemical binding]; other site
205922004406	active site
205922004407	UGI interface [polypeptide binding]; other site
205922004408	catalytic site [active]
205922004409	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
205922004410	Putative ammonia monooxygenase; Region: AmoA; pfam05145
205922004411	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
205922004412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
205922004413	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
205922004414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
205922004415	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
205922004416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922004417	active site
205922004418	phosphorylation site [posttranslational modification]
205922004419	intermolecular recognition site; other site
205922004420	dimerization interface [polypeptide binding]; other site
205922004421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922004422	DNA binding site [nucleotide binding]
205922004423	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
205922004424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922004425	HAMP domain; Region: HAMP; pfam00672
205922004426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922004427	dimer interface [polypeptide binding]; other site
205922004428	phosphorylation site [posttranslational modification]
205922004429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922004430	ATP binding site [chemical binding]; other site
205922004431	Mg2+ binding site [ion binding]; other site
205922004432	G-X-G motif; other site
205922004433	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
205922004434	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
205922004435	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
205922004436	Uncharacterized conserved protein [Function unknown]; Region: COG2938
205922004437	L-aspartate oxidase; Provisional; Region: PRK09077
205922004438	L-aspartate oxidase; Provisional; Region: PRK06175
205922004439	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
205922004440	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
205922004441	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922004442	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922004443	DNA binding residues [nucleotide binding]
205922004444	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
205922004445	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
205922004446	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
205922004447	anti-sigma E factor; Provisional; Region: rseB; PRK09455
205922004448	MucB/RseB family; Region: MucB_RseB; pfam03888
205922004449	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
205922004450	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
205922004451	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
205922004452	protein binding site [polypeptide binding]; other site
205922004453	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
205922004454	protein binding site [polypeptide binding]; other site
205922004455	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
205922004456	Peptidase family M48; Region: Peptidase_M48; cl12018
205922004457	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922004458	TPR motif; other site
205922004459	binding surface
205922004460	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
205922004461	CPxP  motif; other site
205922004462	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
205922004463	Domain of unknown function DUF20; Region: UPF0118; pfam01594
205922004464	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
205922004465	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
205922004466	catalytic triad [active]
205922004467	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
205922004468	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
205922004469	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
205922004470	dihydrodipicolinate synthase; Region: dapA; TIGR00674
205922004471	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
205922004472	dimer interface [polypeptide binding]; other site
205922004473	active site
205922004474	catalytic residue [active]
205922004475	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
205922004476	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
205922004477	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
205922004478	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
205922004479	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
205922004480	ATP binding site [chemical binding]; other site
205922004481	active site
205922004482	substrate binding site [chemical binding]; other site
205922004483	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
205922004484	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
205922004485	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
205922004486	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
205922004487	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
205922004488	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
205922004489	Ligand binding site; other site
205922004490	Putative Catalytic site; other site
205922004491	DXD motif; other site
205922004492	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922004493	Predicted membrane protein [Function unknown]; Region: COG2246
205922004494	GtrA-like protein; Region: GtrA; pfam04138
205922004495	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004497	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
205922004498	putative substrate binding pocket [chemical binding]; other site
205922004499	putative dimerization interface [polypeptide binding]; other site
205922004500	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
205922004501	putative substrate binding pocket [chemical binding]; other site
205922004502	trimer interface [polypeptide binding]; other site
205922004503	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004505	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
205922004506	substrate binding pocket [chemical binding]; other site
205922004507	dimerization interface [polypeptide binding]; other site
205922004508	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
205922004509	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
205922004510	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
205922004511	Sulfatase; Region: Sulfatase; pfam00884
205922004512	ribonuclease D; Region: rnd; TIGR01388
205922004513	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
205922004514	catalytic site [active]
205922004515	putative active site [active]
205922004516	putative substrate binding site [chemical binding]; other site
205922004517	HRDC domain; Region: HRDC; pfam00570
205922004518	YcgL domain; Region: YcgL; pfam05166
205922004519	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
205922004520	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
205922004521	NAD binding site [chemical binding]; other site
205922004522	ligand binding site [chemical binding]; other site
205922004523	catalytic site [active]
205922004524	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
205922004525	putative FMN binding site [chemical binding]; other site
205922004526	hypothetical protein; Provisional; Region: PRK05170
205922004527	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
205922004528	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
205922004529	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
205922004530	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205922004531	active site
205922004532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922004533	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205922004534	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922004535	ligand binding site [chemical binding]; other site
205922004536	flexible hinge region; other site
205922004537	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
205922004538	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922004539	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
205922004540	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
205922004541	putative active site [active]
205922004542	putative dimer interface [polypeptide binding]; other site
205922004543	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
205922004544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004545	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
205922004546	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922004547	dimerization interface [polypeptide binding]; other site
205922004548	benzoate transport; Region: 2A0115; TIGR00895
205922004549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004550	putative substrate translocation pore; other site
205922004551	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
205922004552	putative active site [active]
205922004553	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
205922004554	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
205922004555	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
205922004556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
205922004557	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205922004558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922004559	Walker A motif; other site
205922004560	ATP binding site [chemical binding]; other site
205922004561	Walker B motif; other site
205922004562	arginine finger; other site
205922004563	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
205922004564	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
205922004565	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
205922004566	salt bridge; other site
205922004567	non-specific DNA binding site [nucleotide binding]; other site
205922004568	sequence-specific DNA binding site [nucleotide binding]; other site
205922004569	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
205922004570	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
205922004571	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
205922004572	dimer interface [polypeptide binding]; other site
205922004573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922004574	catalytic residue [active]
205922004575	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
205922004576	EamA-like transporter family; Region: EamA; pfam00892
205922004577	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
205922004578	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922004579	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922004580	dimerization interface [polypeptide binding]; other site
205922004581	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922004582	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922004583	dimer interface [polypeptide binding]; other site
205922004584	putative CheW interface [polypeptide binding]; other site
205922004585	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
205922004586	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
205922004587	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
205922004588	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922004589	ATP binding site [chemical binding]; other site
205922004590	putative Mg++ binding site [ion binding]; other site
205922004591	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922004592	nucleotide binding region [chemical binding]; other site
205922004593	ATP-binding site [chemical binding]; other site
205922004594	Helicase associated domain (HA2); Region: HA2; pfam04408
205922004595	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
205922004596	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
205922004597	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
205922004598	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
205922004599	dimer interface [polypeptide binding]; other site
205922004600	active site
205922004601	CoA binding pocket [chemical binding]; other site
205922004602	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
205922004603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922004604	Putative zinc-finger; Region: zf-HC2; pfam13490
205922004605	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
205922004606	Protein of unknown function, DUF482; Region: DUF482; pfam04339
205922004607	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
205922004608	amphipathic channel; other site
205922004609	Asn-Pro-Ala signature motifs; other site
205922004610	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205922004611	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922004612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922004613	Walker A/P-loop; other site
205922004614	ATP binding site [chemical binding]; other site
205922004615	Q-loop/lid; other site
205922004616	ABC transporter signature motif; other site
205922004617	Walker B; other site
205922004618	D-loop; other site
205922004619	H-loop/switch region; other site
205922004620	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
205922004621	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
205922004622	substrate binding site [chemical binding]; other site
205922004623	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
205922004624	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004626	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922004627	dimerization interface [polypeptide binding]; other site
205922004628	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
205922004629	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922004630	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
205922004631	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004632	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004633	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922004634	putative effector binding pocket; other site
205922004635	dimerization interface [polypeptide binding]; other site
205922004636	Isochorismatase family; Region: Isochorismatase; pfam00857
205922004637	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
205922004638	catalytic triad [active]
205922004639	dimer interface [polypeptide binding]; other site
205922004640	conserved cis-peptide bond; other site
205922004641	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922004642	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922004643	helicase 45; Provisional; Region: PTZ00424
205922004644	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205922004645	ATP binding site [chemical binding]; other site
205922004646	Mg++ binding site [ion binding]; other site
205922004647	motif III; other site
205922004648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922004649	nucleotide binding region [chemical binding]; other site
205922004650	ATP-binding site [chemical binding]; other site
205922004651	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
205922004652	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
205922004653	conserved hypothetical protein, proteobacterial; Region: gcw_chp; TIGR02001
205922004654	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
205922004655	S1 domain; Region: S1_2; pfam13509
205922004656	S1 domain; Region: S1_2; pfam13509
205922004657	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
205922004658	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
205922004659	EamA-like transporter family; Region: EamA; pfam00892
205922004660	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
205922004661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004663	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
205922004664	putative dimerization interface [polypeptide binding]; other site
205922004665	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
205922004666	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
205922004667	Na binding site [ion binding]; other site
205922004668	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
205922004669	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922004670	Na binding site [ion binding]; other site
205922004671	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
205922004672	SnoaL-like domain; Region: SnoaL_3; pfam13474
205922004673	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
205922004674	agmatinase; Region: agmatinase; TIGR01230
205922004675	oligomer interface [polypeptide binding]; other site
205922004676	putative active site [active]
205922004677	Mn binding site [ion binding]; other site
205922004678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922004679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922004680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922004681	dimerization interface [polypeptide binding]; other site
205922004682	Uncharacterized conserved protein [Function unknown]; Region: COG3148
205922004683	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
205922004684	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922004685	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922004686	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
205922004687	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
205922004688	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922004689	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922004690	Walker A/P-loop; other site
205922004691	ATP binding site [chemical binding]; other site
205922004692	Q-loop/lid; other site
205922004693	ABC transporter signature motif; other site
205922004694	Walker B; other site
205922004695	D-loop; other site
205922004696	H-loop/switch region; other site
205922004697	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
205922004698	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
205922004699	VCBS repeat; Region: VCBS_repeat; TIGR01965
205922004700	VCBS repeat; Region: VCBS_repeat; TIGR01965
205922004701	VCBS repeat; Region: VCBS_repeat; TIGR01965
205922004702	VCBS repeat; Region: VCBS_repeat; TIGR01965
205922004703	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
205922004704	VCBS repeat; Region: VCBS_repeat; TIGR01965
205922004705	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
205922004706	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
205922004707	metal ion-dependent adhesion site (MIDAS); other site
205922004708	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
205922004709	Protein of unknown function (DUF454); Region: DUF454; pfam04304
205922004710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
205922004711	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
205922004712	yecA family protein; Region: ygfB_yecA; TIGR02292
205922004713	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
205922004714	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922004715	ATP binding site [chemical binding]; other site
205922004716	putative Mg++ binding site [ion binding]; other site
205922004717	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922004718	nucleotide binding region [chemical binding]; other site
205922004719	ATP-binding site [chemical binding]; other site
205922004720	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
205922004721	HRDC domain; Region: HRDC; pfam00570
205922004722	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922004723	MarR family; Region: MarR_2; pfam12802
205922004724	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
205922004725	hypothetical protein; Provisional; Region: PRK10279
205922004726	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
205922004727	active site
205922004728	nucleophile elbow; other site
205922004729	Surface antigen; Region: Bac_surface_Ag; pfam01103
205922004730	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
205922004731	EamA-like transporter family; Region: EamA; pfam00892
205922004732	EamA-like transporter family; Region: EamA; pfam00892
205922004733	Cupin domain; Region: Cupin_2; pfam07883
205922004734	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922004735	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922004736	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
205922004737	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
205922004738	putative active site [active]
205922004739	putative metal binding site [ion binding]; other site
205922004740	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
205922004741	Protein of unknown function (DUF962); Region: DUF962; pfam06127
205922004742	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922004743	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922004744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922004745	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
205922004746	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
205922004747	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
205922004748	putative FMN binding site [chemical binding]; other site
205922004749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922004750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922004751	ATP binding site [chemical binding]; other site
205922004752	Mg2+ binding site [ion binding]; other site
205922004753	G-X-G motif; other site
205922004754	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
205922004755	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922004756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922004757	active site
205922004758	phosphorylation site [posttranslational modification]
205922004759	intermolecular recognition site; other site
205922004760	dimerization interface [polypeptide binding]; other site
205922004761	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922004762	DNA binding site [nucleotide binding]
205922004763	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
205922004764	YciI-like protein; Reviewed; Region: PRK11370
205922004765	intracellular septation protein A; Reviewed; Region: PRK00259
205922004766	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
205922004767	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
205922004768	active site
205922004769	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
205922004770	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
205922004771	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
205922004772	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
205922004773	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
205922004774	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
205922004775	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922004776	RNA binding surface [nucleotide binding]; other site
205922004777	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
205922004778	probable active site [active]
205922004779	aromatic amino acid transporter; Provisional; Region: PRK10238
205922004780	hypothetical protein; Provisional; Region: PRK09256
205922004781	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
205922004782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922004783	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922004784	putative substrate translocation pore; other site
205922004785	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
205922004786	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922004787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922004788	homodimer interface [polypeptide binding]; other site
205922004789	catalytic residue [active]
205922004790	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
205922004791	aromatic arch; other site
205922004792	DCoH dimer interaction site [polypeptide binding]; other site
205922004793	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
205922004794	DCoH tetramer interaction site [polypeptide binding]; other site
205922004795	substrate binding site [chemical binding]; other site
205922004796	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
205922004797	cofactor binding site; other site
205922004798	metal binding site [ion binding]; metal-binding site
205922004799	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
205922004800	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
205922004801	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922004802	putative active site [active]
205922004803	heme pocket [chemical binding]; other site
205922004804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922004805	Walker A motif; other site
205922004806	ATP binding site [chemical binding]; other site
205922004807	Walker B motif; other site
205922004808	arginine finger; other site
205922004809	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
205922004810	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
205922004811	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
205922004812	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
205922004813	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
205922004814	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
205922004815	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
205922004816	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
205922004817	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
205922004818	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
205922004819	Rod binding protein; Region: Rod-binding; cl01626
205922004820	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
205922004821	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
205922004822	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
205922004823	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
205922004824	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
205922004825	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
205922004826	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
205922004827	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922004828	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
205922004829	active site
205922004830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922004831	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
205922004832	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
205922004833	Probable Catalytic site; other site
205922004834	metal-binding site
205922004835	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922004836	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
205922004837	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922004838	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
205922004839	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
205922004840	substrate binding site; other site
205922004841	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
205922004842	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
205922004843	NAD binding site [chemical binding]; other site
205922004844	homotetramer interface [polypeptide binding]; other site
205922004845	homodimer interface [polypeptide binding]; other site
205922004846	substrate binding site [chemical binding]; other site
205922004847	active site
205922004848	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
205922004849	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
205922004850	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922004851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922004852	S-adenosylmethionine binding site [chemical binding]; other site
205922004853	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
205922004854	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
205922004855	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
205922004856	inhibitor-cofactor binding pocket; inhibition site
205922004857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922004858	catalytic residue [active]
205922004859	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
205922004860	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
205922004861	putative trimer interface [polypeptide binding]; other site
205922004862	putative CoA binding site [chemical binding]; other site
205922004863	Cephalosporin hydroxylase; Region: CmcI; pfam04989
205922004864	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922004865	active site
205922004866	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922004867	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922004868	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922004869	active site
205922004870	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
205922004871	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
205922004872	NAD(P) binding site [chemical binding]; other site
205922004873	homodimer interface [polypeptide binding]; other site
205922004874	substrate binding site [chemical binding]; other site
205922004875	active site
205922004876	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
205922004877	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
205922004878	inhibitor-cofactor binding pocket; inhibition site
205922004879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922004880	catalytic residue [active]
205922004881	pseudaminic acid biosynthesis-associated methylase; Region: Pse_Me-ase; TIGR03587
205922004882	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
205922004883	ligand binding site; other site
205922004884	tetramer interface; other site
205922004885	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
205922004886	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205922004887	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922004888	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
205922004889	pseudaminic acid synthase; Region: PseI; TIGR03586
205922004890	NeuB family; Region: NeuB; pfam03102
205922004891	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
205922004892	NeuB binding interface [polypeptide binding]; other site
205922004893	putative substrate binding site [chemical binding]; other site
205922004894	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
205922004895	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
205922004896	dimer interface [polypeptide binding]; other site
205922004897	active site
205922004898	CoA binding pocket [chemical binding]; other site
205922004899	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
205922004900	flagellin; Provisional; Region: PRK12802
205922004901	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
205922004902	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
205922004903	FlaG protein; Region: FlaG; pfam03646
205922004904	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
205922004905	flagellar capping protein; Reviewed; Region: fliD; PRK08032
205922004906	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
205922004907	flagellar protein FliS; Validated; Region: fliS; PRK05685
205922004908	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922004909	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
205922004910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922004911	Walker A motif; other site
205922004912	ATP binding site [chemical binding]; other site
205922004913	Walker B motif; other site
205922004914	arginine finger; other site
205922004915	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922004916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922004917	dimer interface [polypeptide binding]; other site
205922004918	phosphorylation site [posttranslational modification]
205922004919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922004920	ATP binding site [chemical binding]; other site
205922004921	Mg2+ binding site [ion binding]; other site
205922004922	G-X-G motif; other site
205922004923	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922004924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922004925	active site
205922004926	phosphorylation site [posttranslational modification]
205922004927	intermolecular recognition site; other site
205922004928	dimerization interface [polypeptide binding]; other site
205922004929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922004930	Walker A motif; other site
205922004931	ATP binding site [chemical binding]; other site
205922004932	Walker B motif; other site
205922004933	arginine finger; other site
205922004934	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922004935	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
205922004936	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
205922004937	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
205922004938	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
205922004939	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
205922004940	MgtE intracellular N domain; Region: MgtE_N; cl15244
205922004941	FliG C-terminal domain; Region: FliG_C; pfam01706
205922004942	flagellar assembly protein H; Validated; Region: fliH; PRK05687
205922004943	Flagellar assembly protein FliH; Region: FliH; pfam02108
205922004944	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
205922004945	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
205922004946	Walker A motif/ATP binding site; other site
205922004947	Walker B motif; other site
205922004948	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
205922004949	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
205922004950	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
205922004951	anti sigma factor interaction site; other site
205922004952	regulatory phosphorylation site [posttranslational modification]; other site
205922004953	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922004954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922004955	active site
205922004956	phosphorylation site [posttranslational modification]
205922004957	intermolecular recognition site; other site
205922004958	dimerization interface [polypeptide binding]; other site
205922004959	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
205922004960	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
205922004961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
205922004962	ATP binding site [chemical binding]; other site
205922004963	Mg2+ binding site [ion binding]; other site
205922004964	G-X-G motif; other site
205922004965	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922004966	putative binding surface; other site
205922004967	active site
205922004968	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
205922004969	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
205922004970	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
205922004971	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
205922004972	flagellar motor switch protein; Validated; Region: fliN; PRK05698
205922004973	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
205922004974	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
205922004975	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
205922004976	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
205922004977	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
205922004978	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
205922004979	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
205922004980	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
205922004981	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
205922004982	FHIPEP family; Region: FHIPEP; pfam00771
205922004983	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
205922004984	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922004985	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
205922004986	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922004987	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
205922004988	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
205922004989	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922004990	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
205922004991	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922004992	DNA binding residues [nucleotide binding]
205922004993	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
205922004994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922004995	active site
205922004996	phosphorylation site [posttranslational modification]
205922004997	intermolecular recognition site; other site
205922004998	dimerization interface [polypeptide binding]; other site
205922004999	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
205922005000	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922005001	putative binding surface; other site
205922005002	active site
205922005003	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
205922005004	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
205922005005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922005006	ATP binding site [chemical binding]; other site
205922005007	Mg2+ binding site [ion binding]; other site
205922005008	G-X-G motif; other site
205922005009	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
205922005010	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
205922005011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922005012	active site
205922005013	phosphorylation site [posttranslational modification]
205922005014	intermolecular recognition site; other site
205922005015	dimerization interface [polypeptide binding]; other site
205922005016	CheB methylesterase; Region: CheB_methylest; pfam01339
205922005017	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
205922005018	flagellar motor protein; Reviewed; Region: motC; PRK09109
205922005019	flagellar motor protein MotD; Reviewed; Region: PRK09038
205922005020	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
205922005021	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922005022	ligand binding site [chemical binding]; other site
205922005023	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
205922005024	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922005025	P-loop; other site
205922005026	Magnesium ion binding site [ion binding]; other site
205922005027	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922005028	Magnesium ion binding site [ion binding]; other site
205922005029	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
205922005030	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
205922005031	putative CheA interaction surface; other site
205922005032	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
205922005033	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
205922005034	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
205922005035	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
205922005036	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
205922005037	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
205922005038	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
205922005039	Walker A/P-loop; other site
205922005040	ATP binding site [chemical binding]; other site
205922005041	Q-loop/lid; other site
205922005042	ABC transporter signature motif; other site
205922005043	Walker B; other site
205922005044	D-loop; other site
205922005045	H-loop/switch region; other site
205922005046	CcmB protein; Region: CcmB; cl17444
205922005047	CcmB protein; Region: CcmB; cl17444
205922005048	heme exporter protein CcmC; Region: ccmC; TIGR01191
205922005049	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
205922005050	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
205922005051	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
205922005052	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
205922005053	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
205922005054	catalytic residues [active]
205922005055	central insert; other site
205922005056	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
205922005057	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
205922005058	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
205922005059	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922005060	binding surface
205922005061	TPR motif; other site
205922005062	YcfA-like protein; Region: YcfA; pfam07927
205922005063	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
205922005064	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
205922005065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922005066	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
205922005067	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205922005068	Ion transport protein; Region: Ion_trans; pfam00520
205922005069	Ion channel; Region: Ion_trans_2; pfam07885
205922005070	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
205922005071	Urea transporter; Region: UT; pfam03253
205922005072	pyruvate kinase; Provisional; Region: PRK06247
205922005073	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
205922005074	domain interfaces; other site
205922005075	active site
205922005076	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
205922005077	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
205922005078	MOFRL family; Region: MOFRL; pfam05161
205922005079	tartronate semialdehyde reductase; Provisional; Region: PRK15059
205922005080	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
205922005081	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
205922005082	glyoxylate carboligase; Provisional; Region: PRK11269
205922005083	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
205922005084	PYR/PP interface [polypeptide binding]; other site
205922005085	dimer interface [polypeptide binding]; other site
205922005086	TPP binding site [chemical binding]; other site
205922005087	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
205922005088	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
205922005089	TPP-binding site [chemical binding]; other site
205922005090	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
205922005091	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
205922005092	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922005093	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
205922005094	Protein of unknown function (DUF808); Region: DUF808; pfam05661
205922005095	VacJ like lipoprotein; Region: VacJ; cl01073
205922005096	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
205922005097	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922005098	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
205922005099	Predicted membrane protein [Function unknown]; Region: COG3162
205922005100	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
205922005101	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
205922005102	Na binding site [ion binding]; other site
205922005103	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
205922005104	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
205922005105	dimer interface [polypeptide binding]; other site
205922005106	active site
205922005107	citrylCoA binding site [chemical binding]; other site
205922005108	NADH binding [chemical binding]; other site
205922005109	cationic pore residues; other site
205922005110	oxalacetate/citrate binding site [chemical binding]; other site
205922005111	coenzyme A binding site [chemical binding]; other site
205922005112	catalytic triad [active]
205922005113	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
205922005114	Iron-sulfur protein interface; other site
205922005115	proximal quinone binding site [chemical binding]; other site
205922005116	SdhD (CybS) interface [polypeptide binding]; other site
205922005117	proximal heme binding site [chemical binding]; other site
205922005118	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
205922005119	SdhC subunit interface [polypeptide binding]; other site
205922005120	proximal heme binding site [chemical binding]; other site
205922005121	cardiolipin binding site; other site
205922005122	Iron-sulfur protein interface; other site
205922005123	proximal quinone binding site [chemical binding]; other site
205922005124	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
205922005125	L-aspartate oxidase; Provisional; Region: PRK06175
205922005126	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
205922005127	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
205922005128	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
205922005129	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
205922005130	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
205922005131	TPP-binding site [chemical binding]; other site
205922005132	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
205922005133	dimer interface [polypeptide binding]; other site
205922005134	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
205922005135	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205922005136	E3 interaction surface; other site
205922005137	lipoyl attachment site [posttranslational modification]; other site
205922005138	e3 binding domain; Region: E3_binding; pfam02817
205922005139	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
205922005140	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
205922005141	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
205922005142	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922005143	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205922005144	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
205922005145	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
205922005146	CoA-ligase; Region: Ligase_CoA; pfam00549
205922005147	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
205922005148	CoA binding domain; Region: CoA_binding; pfam02629
205922005149	CoA-ligase; Region: Ligase_CoA; pfam00549
205922005150	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
205922005151	Predicted membrane protein [Function unknown]; Region: COG3821
205922005152	Predicted membrane protein [Function unknown]; Region: COG3686
205922005153	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205922005154	CoenzymeA binding site [chemical binding]; other site
205922005155	subunit interaction site [polypeptide binding]; other site
205922005156	PHB binding site; other site
205922005157	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205922005158	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
205922005159	CoenzymeA binding site [chemical binding]; other site
205922005160	subunit interaction site [polypeptide binding]; other site
205922005161	PHB binding site; other site
205922005162	heat shock protein 90; Provisional; Region: PRK05218
205922005163	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922005164	ATP binding site [chemical binding]; other site
205922005165	Mg2+ binding site [ion binding]; other site
205922005166	G-X-G motif; other site
205922005167	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
205922005168	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922005169	Pirin; Region: Pirin; pfam02678
205922005170	Pirin-related protein [General function prediction only]; Region: COG1741
205922005171	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
205922005172	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
205922005173	Amidohydrolase; Region: Amidohydro_2; pfam04909
205922005174	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922005175	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
205922005176	dimerization interface [polypeptide binding]; other site
205922005177	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922005178	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922005179	dimer interface [polypeptide binding]; other site
205922005180	putative CheW interface [polypeptide binding]; other site
205922005181	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
205922005182	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
205922005183	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
205922005184	active site
205922005185	substrate binding site [chemical binding]; other site
205922005186	cosubstrate binding site; other site
205922005187	catalytic site [active]
205922005188	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
205922005189	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
205922005190	dimerization interface [polypeptide binding]; other site
205922005191	putative ATP binding site [chemical binding]; other site
205922005192	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
205922005193	Domain of unknown function DUF20; Region: UPF0118; pfam01594
205922005194	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
205922005195	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
205922005196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922005197	Walker A motif; other site
205922005198	ATP binding site [chemical binding]; other site
205922005199	Walker B motif; other site
205922005200	arginine finger; other site
205922005201	NlpC/P60 family; Region: NLPC_P60; pfam00877
205922005202	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
205922005203	NlpC/P60 family; Region: NLPC_P60; pfam00877
205922005204	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
205922005205	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
205922005206	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
205922005207	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
205922005208	Walker A motif; other site
205922005209	homodimer interface [polypeptide binding]; other site
205922005210	ATP binding site [chemical binding]; other site
205922005211	hydroxycobalamin binding site [chemical binding]; other site
205922005212	Walker B motif; other site
205922005213	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
205922005214	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
205922005215	catalytic triad [active]
205922005216	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
205922005217	putative FMN binding site [chemical binding]; other site
205922005218	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
205922005219	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
205922005220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922005221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922005222	homodimer interface [polypeptide binding]; other site
205922005223	catalytic residue [active]
205922005224	cobyric acid synthase; Provisional; Region: PRK00784
205922005225	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
205922005226	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
205922005227	catalytic triad [active]
205922005228	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
205922005229	homotrimer interface [polypeptide binding]; other site
205922005230	Walker A motif; other site
205922005231	GTP binding site [chemical binding]; other site
205922005232	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
205922005233	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
205922005234	putative dimer interface [polypeptide binding]; other site
205922005235	active site pocket [active]
205922005236	putative cataytic base [active]
205922005237	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205922005238	catalytic core [active]
205922005239	cobalamin synthase; Reviewed; Region: cobS; PRK00235
205922005240	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922005241	MarR family; Region: MarR_2; cl17246
205922005242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922005243	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922005244	putative substrate translocation pore; other site
205922005245	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
205922005246	catalytic residues [active]
205922005247	dimer interface [polypeptide binding]; other site
205922005248	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
205922005249	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
205922005250	RmuC family; Region: RmuC; pfam02646
205922005251	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
205922005252	Na binding site [ion binding]; other site
205922005253	PAS domain; Region: PAS; smart00091
205922005254	PAS fold; Region: PAS_7; pfam12860
205922005255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922005256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922005257	dimer interface [polypeptide binding]; other site
205922005258	phosphorylation site [posttranslational modification]
205922005259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922005260	ATP binding site [chemical binding]; other site
205922005261	Mg2+ binding site [ion binding]; other site
205922005262	G-X-G motif; other site
205922005263	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922005264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922005265	active site
205922005266	phosphorylation site [posttranslational modification]
205922005267	intermolecular recognition site; other site
205922005268	dimerization interface [polypeptide binding]; other site
205922005269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922005270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922005271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922005272	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922005273	Cupin domain; Region: Cupin_2; cl17218
205922005274	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
205922005275	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
205922005276	gating phenylalanine in ion channel; other site
205922005277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922005278	putative substrate translocation pore; other site
205922005279	H+ Antiporter protein; Region: 2A0121; TIGR00900
205922005280	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922005281	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
205922005282	putative acyl-acceptor binding pocket; other site
205922005283	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
205922005284	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
205922005285	Sodium Bile acid symporter family; Region: SBF; cl17470
205922005286	recombination associated protein; Reviewed; Region: rdgC; PRK00321
205922005287	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
205922005288	putative heme binding pocket [chemical binding]; other site
205922005289	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
205922005290	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
205922005291	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205922005292	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
205922005293	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922005294	non-specific DNA binding site [nucleotide binding]; other site
205922005295	salt bridge; other site
205922005296	sequence-specific DNA binding site [nucleotide binding]; other site
205922005297	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922005298	RHS Repeat; Region: RHS_repeat; pfam05593
205922005299	RHS Repeat; Region: RHS_repeat; pfam05593
205922005300	RHS Repeat; Region: RHS_repeat; cl11982
205922005301	RHS Repeat; Region: RHS_repeat; pfam05593
205922005302	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
205922005303	RHS Repeat; Region: RHS_repeat; pfam05593
205922005304	RHS Repeat; Region: RHS_repeat; pfam05593
205922005305	RHS Repeat; Region: RHS_repeat; pfam05593
205922005306	RHS protein; Region: RHS; pfam03527
205922005307	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922005308	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922005309	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
205922005310	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922005311	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922005312	metal binding site [ion binding]; metal-binding site
205922005313	active site
205922005314	I-site; other site
205922005315	carboxy-terminal protease; Provisional; Region: PRK11186
205922005316	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
205922005317	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
205922005318	protein binding site [polypeptide binding]; other site
205922005319	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
205922005320	Catalytic dyad [active]
205922005321	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
205922005322	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
205922005323	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
205922005324	NAD(P) binding site [chemical binding]; other site
205922005325	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
205922005326	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205922005327	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922005328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922005329	Walker A/P-loop; other site
205922005330	ATP binding site [chemical binding]; other site
205922005331	Q-loop/lid; other site
205922005332	ABC transporter signature motif; other site
205922005333	Walker B; other site
205922005334	D-loop; other site
205922005335	H-loop/switch region; other site
205922005336	TOBE domain; Region: TOBE_2; pfam08402
205922005337	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922005338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922005339	dimer interface [polypeptide binding]; other site
205922005340	conserved gate region; other site
205922005341	putative PBP binding loops; other site
205922005342	ABC-ATPase subunit interface; other site
205922005343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922005344	dimer interface [polypeptide binding]; other site
205922005345	conserved gate region; other site
205922005346	putative PBP binding loops; other site
205922005347	ABC-ATPase subunit interface; other site
205922005348	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
205922005349	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
205922005350	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
205922005351	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205922005352	transcriptional regulator protein; Region: phnR; TIGR03337
205922005353	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922005354	DNA-binding site [nucleotide binding]; DNA binding site
205922005355	UTRA domain; Region: UTRA; pfam07702
205922005356	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922005357	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922005358	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
205922005359	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
205922005360	active site
205922005361	metal binding site [ion binding]; metal-binding site
205922005362	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
205922005363	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
205922005364	active site
205922005365	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
205922005366	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
205922005367	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
205922005368	Switch I; other site
205922005369	Switch II; other site
205922005370	septum formation inhibitor; Reviewed; Region: minC; PRK00339
205922005371	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
205922005372	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
205922005373	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
205922005374	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
205922005375	putative acyl-acceptor binding pocket; other site
205922005376	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
205922005377	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
205922005378	active site
205922005379	nucleophile elbow; other site
205922005380	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
205922005381	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
205922005382	xanthine permease; Region: pbuX; TIGR03173
205922005383	Predicted membrane protein [Function unknown]; Region: COG3748
205922005384	Protein of unknown function (DUF989); Region: DUF989; pfam06181
205922005385	Cytochrome c; Region: Cytochrom_C; pfam00034
205922005386	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
205922005387	ureidoglycolate hydrolase; Provisional; Region: PRK03606
205922005388	allantoicase; Provisional; Region: PRK13257
205922005389	Allantoicase repeat; Region: Allantoicase; pfam03561
205922005390	Allantoicase repeat; Region: Allantoicase; pfam03561
205922005391	OHCU decarboxylase; Region: UHCUDC; TIGR03164
205922005392	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
205922005393	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
205922005394	active site
205922005395	catalytic site [active]
205922005396	tetramer interface [polypeptide binding]; other site
205922005397	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
205922005398	active site
205922005399	homotetramer interface [polypeptide binding]; other site
205922005400	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922005401	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
205922005402	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922005403	MarR family; Region: MarR_2; pfam12802
205922005404	aspartate aminotransferase; Provisional; Region: PRK05764
205922005405	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922005406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922005407	homodimer interface [polypeptide binding]; other site
205922005408	catalytic residue [active]
205922005409	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922005410	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
205922005411	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
205922005412	homodecamer interface [polypeptide binding]; other site
205922005413	GTP cyclohydrolase I; Provisional; Region: PLN03044
205922005414	active site
205922005415	putative catalytic site residues [active]
205922005416	zinc binding site [ion binding]; other site
205922005417	GTP-CH-I/GFRP interaction surface; other site
205922005418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
205922005419	Smr domain; Region: Smr; pfam01713
205922005420	Isochorismatase family; Region: Isochorismatase; pfam00857
205922005421	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
205922005422	catalytic triad [active]
205922005423	conserved cis-peptide bond; other site
205922005424	HemK family putative methylases; Region: hemK_fam; TIGR00536
205922005425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922005426	S-adenosylmethionine binding site [chemical binding]; other site
205922005427	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
205922005428	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
205922005429	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
205922005430	Tetramer interface [polypeptide binding]; other site
205922005431	active site
205922005432	FMN-binding site [chemical binding]; other site
205922005433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922005434	putative substrate translocation pore; other site
205922005435	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
205922005436	intersubunit interface [polypeptide binding]; other site
205922005437	active site
205922005438	Zn2+ binding site [ion binding]; other site
205922005439	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
205922005440	Cupin domain; Region: Cupin_2; pfam07883
205922005441	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
205922005442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922005443	motif II; other site
205922005444	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
205922005445	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
205922005446	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922005447	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
205922005448	acyl-activating enzyme (AAE) consensus motif; other site
205922005449	putative AMP binding site [chemical binding]; other site
205922005450	putative active site [active]
205922005451	putative CoA binding site [chemical binding]; other site
205922005452	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
205922005453	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
205922005454	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
205922005455	spermidine synthase; Provisional; Region: PRK00811
205922005456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922005457	S-adenosylmethionine binding site [chemical binding]; other site
205922005458	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
205922005459	Uncharacterized conserved protein [Function unknown]; Region: COG2308
205922005460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
205922005461	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
205922005462	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
205922005463	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
205922005464	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
205922005465	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922005466	Cytochrome c; Region: Cytochrom_C; pfam00034
205922005467	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
205922005468	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922005469	dimer interface [polypeptide binding]; other site
205922005470	active site
205922005471	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
205922005472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922005473	substrate binding site [chemical binding]; other site
205922005474	oxyanion hole (OAH) forming residues; other site
205922005475	trimer interface [polypeptide binding]; other site
205922005476	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922005477	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922005478	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
205922005479	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
205922005480	catalytic triad [active]
205922005481	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
205922005482	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
205922005483	oligomer interface [polypeptide binding]; other site
205922005484	metal binding site [ion binding]; metal-binding site
205922005485	metal binding site [ion binding]; metal-binding site
205922005486	putative Cl binding site [ion binding]; other site
205922005487	basic sphincter; other site
205922005488	hydrophobic gate; other site
205922005489	periplasmic entrance; other site
205922005490	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
205922005491	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
205922005492	putative acyl-acceptor binding pocket; other site
205922005493	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
205922005494	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922005495	substrate binding site [chemical binding]; other site
205922005496	oxyanion hole (OAH) forming residues; other site
205922005497	trimer interface [polypeptide binding]; other site
205922005498	Uncharacterized conserved protein [Function unknown]; Region: COG0393
205922005499	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922005500	RHS Repeat; Region: RHS_repeat; pfam05593
205922005501	RHS Repeat; Region: RHS_repeat; pfam05593
205922005502	RHS Repeat; Region: RHS_repeat; cl11982
205922005503	RHS Repeat; Region: RHS_repeat; pfam05593
205922005504	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
205922005505	RHS Repeat; Region: RHS_repeat; pfam05593
205922005506	RHS Repeat; Region: RHS_repeat; pfam05593
205922005507	RHS Repeat; Region: RHS_repeat; pfam05593
205922005508	RHS protein; Region: RHS; pfam03527
205922005509	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922005510	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205922005511	hydrolase; Region: PLN02811
205922005512	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922005513	motif II; other site
205922005514	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
205922005515	classical (c) SDRs; Region: SDR_c; cd05233
205922005516	NAD(P) binding site [chemical binding]; other site
205922005517	active site
205922005518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922005519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922005520	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922005521	putative effector binding pocket; other site
205922005522	dimerization interface [polypeptide binding]; other site
205922005523	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
205922005524	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
205922005525	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922005526	Na binding site [ion binding]; other site
205922005527	putative substrate binding site [chemical binding]; other site
205922005528	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
205922005529	Active Sites [active]
205922005530	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
205922005531	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
205922005532	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
205922005533	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
205922005534	chorismate binding enzyme; Region: Chorismate_bind; cl10555
205922005535	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
205922005536	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
205922005537	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
205922005538	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
205922005539	Transcriptional regulators [Transcription]; Region: GntR; COG1802
205922005540	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922005541	DNA-binding site [nucleotide binding]; DNA binding site
205922005542	FCD domain; Region: FCD; pfam07729
205922005543	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
205922005544	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
205922005545	tetramer interface [polypeptide binding]; other site
205922005546	active site
205922005547	Mg2+/Mn2+ binding site [ion binding]; other site
205922005548	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
205922005549	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
205922005550	dimer interface [polypeptide binding]; other site
205922005551	active site
205922005552	citrylCoA binding site [chemical binding]; other site
205922005553	oxalacetate/citrate binding site [chemical binding]; other site
205922005554	coenzyme A binding site [chemical binding]; other site
205922005555	catalytic triad [active]
205922005556	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
205922005557	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
205922005558	substrate binding site [chemical binding]; other site
205922005559	ligand binding site [chemical binding]; other site
205922005560	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
205922005561	substrate binding site [chemical binding]; other site
205922005562	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
205922005563	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
205922005564	2-methylcitrate dehydratase; Region: prpD; TIGR02330
205922005565	PEP synthetase regulatory protein; Provisional; Region: PRK05339
205922005566	phosphoenolpyruvate synthase; Validated; Region: PRK06464
205922005567	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
205922005568	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205922005569	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
205922005570	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
205922005571	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922005572	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
205922005573	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
205922005574	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
205922005575	Cl binding site [ion binding]; other site
205922005576	oligomer interface [polypeptide binding]; other site
205922005577	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
205922005578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922005579	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922005580	DNA binding residues [nucleotide binding]
205922005581	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
205922005582	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922005583	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922005584	ligand binding site [chemical binding]; other site
205922005585	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
205922005586	active site
205922005587	SAM binding site [chemical binding]; other site
205922005588	homodimer interface [polypeptide binding]; other site
205922005589	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
205922005590	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
205922005591	[4Fe-4S] binding site [ion binding]; other site
205922005592	molybdopterin cofactor binding site; other site
205922005593	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
205922005594	molybdopterin cofactor binding site; other site
205922005595	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
205922005596	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
205922005597	[2Fe-2S] cluster binding site [ion binding]; other site
205922005598	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
205922005599	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922005600	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922005601	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
205922005602	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
205922005603	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922005604	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
205922005605	active site
205922005606	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
205922005607	Catalytic domain of Protein Kinases; Region: PKc; cd00180
205922005608	active site
205922005609	ATP binding site [chemical binding]; other site
205922005610	substrate binding site [chemical binding]; other site
205922005611	activation loop (A-loop); other site
205922005612	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
205922005613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922005614	putative substrate translocation pore; other site
205922005615	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
205922005616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922005617	active site
205922005618	phosphorylation site [posttranslational modification]
205922005619	intermolecular recognition site; other site
205922005620	dimerization interface [polypeptide binding]; other site
205922005621	ANTAR domain; Region: ANTAR; pfam03861
205922005622	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
205922005623	NMT1-like family; Region: NMT1_2; pfam13379
205922005624	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
205922005625	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
205922005626	quinone interaction residues [chemical binding]; other site
205922005627	active site
205922005628	catalytic residues [active]
205922005629	FMN binding site [chemical binding]; other site
205922005630	substrate binding site [chemical binding]; other site
205922005631	Ribosome modulation factor; Region: RMF; pfam04957
205922005632	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
205922005633	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
205922005634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922005635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922005636	S-adenosylmethionine binding site [chemical binding]; other site
205922005637	CHASE domain; Region: CHASE; pfam03924
205922005638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922005639	PAS domain; Region: PAS_9; pfam13426
205922005640	putative active site [active]
205922005641	heme pocket [chemical binding]; other site
205922005642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922005643	PAS fold; Region: PAS_3; pfam08447
205922005644	putative active site [active]
205922005645	heme pocket [chemical binding]; other site
205922005646	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922005647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922005648	metal binding site [ion binding]; metal-binding site
205922005649	active site
205922005650	I-site; other site
205922005651	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
205922005652	hypothetical protein; Provisional; Region: PRK11702
205922005653	benzoate transporter; Region: benE; TIGR00843
205922005654	Benzoate membrane transport protein; Region: BenE; pfam03594
205922005655	Transcriptional regulators [Transcription]; Region: GntR; COG1802
205922005656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922005657	DNA-binding site [nucleotide binding]; DNA binding site
205922005658	FCD domain; Region: FCD; pfam07729
205922005659	guanine deaminase; Provisional; Region: PRK09228
205922005660	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
205922005661	active site
205922005662	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
205922005663	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
205922005664	XdhC Rossmann domain; Region: XdhC_C; pfam13478
205922005665	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
205922005666	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922005667	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922005668	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
205922005669	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922005670	catalytic loop [active]
205922005671	iron binding site [ion binding]; other site
205922005672	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922005673	FAD binding domain; Region: FAD_binding_4; pfam01565
205922005674	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
205922005675	Transcriptional regulators [Transcription]; Region: GntR; COG1802
205922005676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922005677	DNA-binding site [nucleotide binding]; DNA binding site
205922005678	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
205922005679	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
205922005680	Walker A/P-loop; other site
205922005681	ATP binding site [chemical binding]; other site
205922005682	Q-loop/lid; other site
205922005683	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
205922005684	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
205922005685	ABC transporter signature motif; other site
205922005686	Walker B; other site
205922005687	D-loop; other site
205922005688	H-loop/switch region; other site
205922005689	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
205922005690	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
205922005691	FtsZ protein binding site [polypeptide binding]; other site
205922005692	Ligase N family; Region: LIGANc; smart00532
205922005693	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
205922005694	nucleotide binding pocket [chemical binding]; other site
205922005695	K-X-D-G motif; other site
205922005696	catalytic site [active]
205922005697	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
205922005698	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
205922005699	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
205922005700	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
205922005701	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
205922005702	Dimer interface [polypeptide binding]; other site
205922005703	BRCT sequence motif; other site
205922005704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
205922005705	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
205922005706	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
205922005707	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922005708	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
205922005709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922005710	Walker A motif; other site
205922005711	ATP binding site [chemical binding]; other site
205922005712	Walker B motif; other site
205922005713	arginine finger; other site
205922005714	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
205922005715	hypothetical protein; Validated; Region: PRK00153
205922005716	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
205922005717	Prostaglandin dehydrogenases; Region: PGDH; cd05288
205922005718	NAD(P) binding site [chemical binding]; other site
205922005719	substrate binding site [chemical binding]; other site
205922005720	dimer interface [polypeptide binding]; other site
205922005721	recombination protein RecR; Reviewed; Region: recR; PRK00076
205922005722	RecR protein; Region: RecR; pfam02132
205922005723	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
205922005724	putative active site [active]
205922005725	putative metal-binding site [ion binding]; other site
205922005726	tetramer interface [polypeptide binding]; other site
205922005727	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922005728	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922005729	active site
205922005730	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922005731	active site
205922005732	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
205922005733	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922005734	ligand binding site [chemical binding]; other site
205922005735	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
205922005736	putative switch regulator; other site
205922005737	non-specific DNA interactions [nucleotide binding]; other site
205922005738	DNA binding site [nucleotide binding]
205922005739	sequence specific DNA binding site [nucleotide binding]; other site
205922005740	putative cAMP binding site [chemical binding]; other site
205922005741	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
205922005742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922005743	FeS/SAM binding site; other site
205922005744	HemN C-terminal domain; Region: HemN_C; pfam06969
205922005745	Uncharacterized conserved protein [Function unknown]; Region: COG2836
205922005746	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
205922005747	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
205922005748	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
205922005749	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
205922005750	metal-binding site [ion binding]
205922005751	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205922005752	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922005753	motif II; other site
205922005754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
205922005755	FixH; Region: FixH; pfam05751
205922005756	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
205922005757	4Fe-4S binding domain; Region: Fer4_5; pfam12801
205922005758	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
205922005759	Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555
205922005760	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
205922005761	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922005762	Cytochrome c; Region: Cytochrom_C; pfam00034
205922005763	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
205922005764	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
205922005765	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
205922005766	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
205922005767	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
205922005768	Low-spin heme binding site [chemical binding]; other site
205922005769	Putative water exit pathway; other site
205922005770	Binuclear center (active site) [active]
205922005771	Putative proton exit pathway; other site
205922005772	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
205922005773	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922005774	Cytochrome c; Region: Cytochrom_C; pfam00034
205922005775	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
205922005776	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
205922005777	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
205922005778	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
205922005779	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
205922005780	Low-spin heme binding site [chemical binding]; other site
205922005781	Putative water exit pathway; other site
205922005782	Binuclear center (active site) [active]
205922005783	Putative proton exit pathway; other site
205922005784	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
205922005785	26S proteasome subunit RPN7; Region: RPN7; pfam10602
205922005786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922005787	AAA domain; Region: AAA_23; pfam13476
205922005788	Walker A/P-loop; other site
205922005789	ATP binding site [chemical binding]; other site
205922005790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922005791	ABC transporter signature motif; other site
205922005792	Walker B; other site
205922005793	D-loop; other site
205922005794	H-loop/switch region; other site
205922005795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922005796	PAS domain; Region: PAS_9; pfam13426
205922005797	putative active site [active]
205922005798	heme pocket [chemical binding]; other site
205922005799	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922005800	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922005801	dimer interface [polypeptide binding]; other site
205922005802	putative CheW interface [polypeptide binding]; other site
205922005803	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
205922005804	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
205922005805	conserved cys residue [active]
205922005806	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922005807	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922005808	conserved cys residue [active]
205922005809	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922005810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922005811	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922005812	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922005813	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
205922005814	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
205922005815	glucose-1-dehydrogenase; Provisional; Region: PRK08936
205922005816	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
205922005817	NAD binding site [chemical binding]; other site
205922005818	homodimer interface [polypeptide binding]; other site
205922005819	active site
205922005820	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
205922005821	substrate binding pocket [chemical binding]; other site
205922005822	substrate-Mg2+ binding site; other site
205922005823	aspartate-rich region 1; other site
205922005824	active site lid residues [active]
205922005825	aspartate-rich region 2; other site
205922005826	SCP-2 sterol transfer family; Region: SCP2; pfam02036
205922005827	Cupin-like domain; Region: Cupin_8; pfam13621
205922005828	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
205922005829	Condensation domain; Region: Condensation; pfam00668
205922005830	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005831	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922005832	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
205922005833	acyl-activating enzyme (AAE) consensus motif; other site
205922005834	AMP binding site [chemical binding]; other site
205922005835	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005836	Condensation domain; Region: Condensation; pfam00668
205922005837	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005838	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
205922005839	Condensation domain; Region: Condensation; pfam00668
205922005840	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005841	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005842	acyl-activating enzyme (AAE) consensus motif; other site
205922005843	AMP binding site [chemical binding]; other site
205922005844	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005845	Condensation domain; Region: Condensation; pfam00668
205922005846	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005847	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
205922005848	Condensation domain; Region: Condensation; pfam00668
205922005849	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005850	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005851	acyl-activating enzyme (AAE) consensus motif; other site
205922005852	AMP binding site [chemical binding]; other site
205922005853	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005854	Condensation domain; Region: Condensation; pfam00668
205922005855	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005856	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
205922005857	Condensation domain; Region: Condensation; pfam00668
205922005858	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005859	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005860	acyl-activating enzyme (AAE) consensus motif; other site
205922005861	AMP binding site [chemical binding]; other site
205922005862	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005863	peptide synthase; Provisional; Region: PRK12467
205922005864	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922005865	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005866	acyl-activating enzyme (AAE) consensus motif; other site
205922005867	AMP binding site [chemical binding]; other site
205922005868	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005869	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922005870	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005871	acyl-activating enzyme (AAE) consensus motif; other site
205922005872	AMP binding site [chemical binding]; other site
205922005873	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005874	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
205922005875	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005876	acyl-activating enzyme (AAE) consensus motif; other site
205922005877	AMP binding site [chemical binding]; other site
205922005878	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005879	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922005880	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922005881	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
205922005882	Condensation domain; Region: Condensation; pfam00668
205922005883	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005884	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922005885	acyl-activating enzyme (AAE) consensus motif; other site
205922005886	AMP binding site [chemical binding]; other site
205922005887	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005888	Secretin and TonB N terminus short domain; Region: STN; pfam07660
205922005889	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
205922005890	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922005891	N-terminal plug; other site
205922005892	ligand-binding site [chemical binding]; other site
205922005893	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
205922005894	RNA polymerase II transcription mediator complex subunit 9; Region: Med9; pfam07544
205922005895	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922005896	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922005897	acyl-activating enzyme (AAE) consensus motif; other site
205922005898	AMP binding site [chemical binding]; other site
205922005899	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922005900	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
205922005901	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922005902	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
205922005903	Walker A/P-loop; other site
205922005904	ATP binding site [chemical binding]; other site
205922005905	Q-loop/lid; other site
205922005906	ABC transporter signature motif; other site
205922005907	Walker B; other site
205922005908	D-loop; other site
205922005909	H-loop/switch region; other site
205922005910	Uncharacterized conserved protein [Function unknown]; Region: COG1262
205922005911	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
205922005912	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
205922005913	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
205922005914	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922005915	catalytic residue [active]
205922005916	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922005917	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
205922005918	active site
205922005919	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922005920	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922005921	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
205922005922	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205922005923	Walker A/P-loop; other site
205922005924	ATP binding site [chemical binding]; other site
205922005925	Q-loop/lid; other site
205922005926	ABC transporter signature motif; other site
205922005927	Walker B; other site
205922005928	D-loop; other site
205922005929	H-loop/switch region; other site
205922005930	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205922005931	FtsX-like permease family; Region: FtsX; pfam02687
205922005932	macrolide transporter subunit MacA; Provisional; Region: PRK11578
205922005933	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922005934	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922005935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922005936	RNA polymerase sigma factor; Reviewed; Region: PRK12527
205922005937	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922005938	DNA binding residues [nucleotide binding]
205922005939	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
205922005940	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922005941	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
205922005942	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
205922005943	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205922005944	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
205922005945	Soluble P-type ATPase [General function prediction only]; Region: COG4087
205922005946	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
205922005947	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
205922005948	MgtC family; Region: MgtC; pfam02308
205922005949	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922005950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922005951	active site
205922005952	phosphorylation site [posttranslational modification]
205922005953	intermolecular recognition site; other site
205922005954	dimerization interface [polypeptide binding]; other site
205922005955	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922005956	DNA binding residues [nucleotide binding]
205922005957	dimerization interface [polypeptide binding]; other site
205922005958	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
205922005959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922005960	substrate binding pocket [chemical binding]; other site
205922005961	membrane-bound complex binding site; other site
205922005962	hinge residues; other site
205922005963	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922005964	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922005965	substrate binding pocket [chemical binding]; other site
205922005966	membrane-bound complex binding site; other site
205922005967	hinge residues; other site
205922005968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922005969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922005970	dimer interface [polypeptide binding]; other site
205922005971	phosphorylation site [posttranslational modification]
205922005972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922005973	ATP binding site [chemical binding]; other site
205922005974	Mg2+ binding site [ion binding]; other site
205922005975	G-X-G motif; other site
205922005976	Response regulator receiver domain; Region: Response_reg; pfam00072
205922005977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922005978	active site
205922005979	phosphorylation site [posttranslational modification]
205922005980	intermolecular recognition site; other site
205922005981	dimerization interface [polypeptide binding]; other site
205922005982	Hpt domain; Region: Hpt; pfam01627
205922005983	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922005984	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922005985	active site
205922005986	catalytic tetrad [active]
205922005987	Pirin-related protein [General function prediction only]; Region: COG1741
205922005988	Pirin; Region: Pirin; pfam02678
205922005989	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
205922005990	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922005991	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922005992	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205922005993	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922005994	ligand binding site [chemical binding]; other site
205922005995	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
205922005996	putative catalytic site [active]
205922005997	putative phosphate binding site [ion binding]; other site
205922005998	active site
205922005999	metal binding site A [ion binding]; metal-binding site
205922006000	DNA binding site [nucleotide binding]
205922006001	putative AP binding site [nucleotide binding]; other site
205922006002	putative metal binding site B [ion binding]; other site
205922006003	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
205922006004	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
205922006005	xanthine permease; Region: pbuX; TIGR03173
205922006006	Sulfate transporter family; Region: Sulfate_transp; pfam00916
205922006007	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
205922006008	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922006009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922006010	homodimer interface [polypeptide binding]; other site
205922006011	catalytic residue [active]
205922006012	excinuclease ABC subunit B; Provisional; Region: PRK05298
205922006013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922006014	ATP binding site [chemical binding]; other site
205922006015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922006016	nucleotide binding region [chemical binding]; other site
205922006017	ATP-binding site [chemical binding]; other site
205922006018	Ultra-violet resistance protein B; Region: UvrB; pfam12344
205922006019	UvrB/uvrC motif; Region: UVR; pfam02151
205922006020	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
205922006021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922006022	putative substrate translocation pore; other site
205922006023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922006024	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
205922006025	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922006026	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922006027	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
205922006028	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
205922006029	active site
205922006030	HIGH motif; other site
205922006031	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
205922006032	active site
205922006033	KMSKS motif; other site
205922006034	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922006035	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922006036	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922006037	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922006038	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
205922006039	active site
205922006040	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
205922006041	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
205922006042	FMN binding site [chemical binding]; other site
205922006043	active site
205922006044	catalytic residues [active]
205922006045	substrate binding site [chemical binding]; other site
205922006046	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
205922006047	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
205922006048	putative dimer interface [polypeptide binding]; other site
205922006049	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
205922006050	DnaJ domain; Region: DnaJ; pfam00226
205922006051	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
205922006052	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
205922006053	nucleotide binding site [chemical binding]; other site
205922006054	putative NEF/HSP70 interaction site [polypeptide binding]; other site
205922006055	SBD interface [polypeptide binding]; other site
205922006056	PAS fold; Region: PAS_3; pfam08447
205922006057	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922006058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922006059	putative active site [active]
205922006060	heme pocket [chemical binding]; other site
205922006061	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
205922006062	PAS domain S-box; Region: sensory_box; TIGR00229
205922006063	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922006064	putative active site [active]
205922006065	heme pocket [chemical binding]; other site
205922006066	PAS domain S-box; Region: sensory_box; TIGR00229
205922006067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922006068	putative active site [active]
205922006069	heme pocket [chemical binding]; other site
205922006070	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922006071	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922006072	metal binding site [ion binding]; metal-binding site
205922006073	active site
205922006074	I-site; other site
205922006075	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922006076	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922006077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006078	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922006079	dimerization interface [polypeptide binding]; other site
205922006080	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
205922006081	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
205922006082	substrate binding site [chemical binding]; other site
205922006083	ligand binding site [chemical binding]; other site
205922006084	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
205922006085	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
205922006086	substrate binding site [chemical binding]; other site
205922006087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922006088	S-adenosylmethionine binding site [chemical binding]; other site
205922006089	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
205922006090	tartrate dehydrogenase; Region: TTC; TIGR02089
205922006091	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
205922006092	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
205922006093	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
205922006094	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
205922006095	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
205922006096	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922006097	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
205922006098	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
205922006099	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
205922006100	dimerization interface 3.5A [polypeptide binding]; other site
205922006101	active site
205922006102	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
205922006103	active site
205922006104	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
205922006105	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
205922006106	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
205922006107	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205922006108	Sporulation related domain; Region: SPOR; pfam05036
205922006109	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
205922006110	Colicin V production protein; Region: Colicin_V; cl00567
205922006111	amidophosphoribosyltransferase; Provisional; Region: PRK09246
205922006112	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
205922006113	active site
205922006114	tetramer interface [polypeptide binding]; other site
205922006115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922006116	active site
205922006117	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
205922006118	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
205922006119	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
205922006120	homodimer interface [polypeptide binding]; other site
205922006121	substrate-cofactor binding pocket; other site
205922006122	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922006123	catalytic residue [active]
205922006124	oxidoreductase; Validated; Region: PRK05717
205922006125	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922006126	NAD(P) binding site [chemical binding]; other site
205922006127	active site
205922006128	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922006129	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
205922006130	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922006131	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922006132	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922006133	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
205922006134	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922006135	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922006136	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
205922006137	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922006138	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
205922006139	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
205922006140	XdhC Rossmann domain; Region: XdhC_C; pfam13478
205922006141	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922006142	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922006143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922006144	Coenzyme A binding pocket [chemical binding]; other site
205922006145	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
205922006146	carbon storage regulator; Provisional; Region: PRK01712
205922006147	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
205922006148	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
205922006149	FAD binding pocket [chemical binding]; other site
205922006150	FAD binding motif [chemical binding]; other site
205922006151	phosphate binding motif [ion binding]; other site
205922006152	NAD binding pocket [chemical binding]; other site
205922006153	DNA-specific endonuclease I; Provisional; Region: PRK15137
205922006154	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
205922006155	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
205922006156	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
205922006157	homodimer interface [polypeptide binding]; other site
205922006158	active site
205922006159	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
205922006160	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
205922006161	ligand binding site [chemical binding]; other site
205922006162	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
205922006163	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205922006164	Walker A/P-loop; other site
205922006165	ATP binding site [chemical binding]; other site
205922006166	Q-loop/lid; other site
205922006167	ABC transporter signature motif; other site
205922006168	Walker B; other site
205922006169	D-loop; other site
205922006170	H-loop/switch region; other site
205922006171	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205922006172	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922006173	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
205922006174	TM-ABC transporter signature motif; other site
205922006175	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205922006176	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205922006177	DNA binding site [nucleotide binding]
205922006178	domain linker motif; other site
205922006179	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
205922006180	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205922006181	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
205922006182	substrate binding site [chemical binding]; other site
205922006183	dimer interface [polypeptide binding]; other site
205922006184	ATP binding site [chemical binding]; other site
205922006185	D-ribose pyranase; Provisional; Region: PRK11797
205922006186	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
205922006187	active site
205922006188	tetramer interface [polypeptide binding]; other site
205922006189	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
205922006190	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205922006191	DNA-binding site [nucleotide binding]; DNA binding site
205922006192	RNA-binding motif; other site
205922006193	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
205922006194	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
205922006195	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
205922006196	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
205922006197	active site
205922006198	dimer interface [polypeptide binding]; other site
205922006199	motif 1; other site
205922006200	motif 2; other site
205922006201	motif 3; other site
205922006202	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
205922006203	anticodon binding site; other site
205922006204	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
205922006205	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
205922006206	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
205922006207	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
205922006208	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
205922006209	23S rRNA binding site [nucleotide binding]; other site
205922006210	L21 binding site [polypeptide binding]; other site
205922006211	L13 binding site [polypeptide binding]; other site
205922006212	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
205922006213	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
205922006214	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
205922006215	dimer interface [polypeptide binding]; other site
205922006216	motif 1; other site
205922006217	active site
205922006218	motif 2; other site
205922006219	motif 3; other site
205922006220	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
205922006221	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
205922006222	putative tRNA-binding site [nucleotide binding]; other site
205922006223	B3/4 domain; Region: B3_4; pfam03483
205922006224	tRNA synthetase B5 domain; Region: B5; smart00874
205922006225	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
205922006226	dimer interface [polypeptide binding]; other site
205922006227	motif 1; other site
205922006228	motif 3; other site
205922006229	motif 2; other site
205922006230	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
205922006231	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
205922006232	IHF dimer interface [polypeptide binding]; other site
205922006233	IHF - DNA interface [nucleotide binding]; other site
205922006234	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
205922006235	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205922006236	DNA binding residues [nucleotide binding]
205922006237	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
205922006238	Part of AAA domain; Region: AAA_19; pfam13245
205922006239	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
205922006240	AAA domain; Region: AAA_30; pfam13604
205922006241	AAA domain; Region: AAA_12; pfam13087
205922006242	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
205922006243	putative active site [active]
205922006244	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
205922006245	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
205922006246	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
205922006247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922006248	Walker A motif; other site
205922006249	ATP binding site [chemical binding]; other site
205922006250	Walker B motif; other site
205922006251	arginine finger; other site
205922006252	TROVE domain; Region: TROVE; pfam05731
205922006253	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
205922006254	metal ion-dependent adhesion site (MIDAS); other site
205922006255	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
205922006256	hypothetical protein; Reviewed; Region: PRK09588
205922006257	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
205922006258	active site
205922006259	NTP binding site [chemical binding]; other site
205922006260	metal binding triad [ion binding]; metal-binding site
205922006261	antibiotic binding site [chemical binding]; other site
205922006262	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
205922006263	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
205922006264	putative active site [active]
205922006265	adenylation catalytic residue [active]
205922006266	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922006267	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
205922006268	dimer interface [polypeptide binding]; other site
205922006269	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922006270	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
205922006271	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
205922006272	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
205922006273	NAD(P) binding site [chemical binding]; other site
205922006274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922006275	putative substrate translocation pore; other site
205922006276	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922006277	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006278	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922006279	dimerization interface [polypeptide binding]; other site
205922006280	Pirin-related protein [General function prediction only]; Region: COG1741
205922006281	Pirin; Region: Pirin; pfam02678
205922006282	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922006283	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922006284	conserved cys residue [active]
205922006285	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006287	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922006288	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922006289	DNA binding site [nucleotide binding]
205922006290	Predicted ATPase [General function prediction only]; Region: COG3903
205922006291	NTPase; Region: NTPase_1; cl17478
205922006292	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922006293	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922006294	DNA binding site [nucleotide binding]
205922006295	Predicted ATPase [General function prediction only]; Region: COG3903
205922006296	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
205922006297	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922006298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006299	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922006300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006301	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
205922006302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922006303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006304	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
205922006305	putative substrate binding pocket [chemical binding]; other site
205922006306	putative dimerization interface [polypeptide binding]; other site
205922006307	Predicted membrane protein [Function unknown]; Region: COG2259
205922006308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
205922006309	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
205922006310	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
205922006311	active site
205922006312	Isochorismatase family; Region: Isochorismatase; pfam00857
205922006313	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
205922006314	catalytic triad [active]
205922006315	dimer interface [polypeptide binding]; other site
205922006316	conserved cis-peptide bond; other site
205922006317	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922006318	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922006319	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205922006320	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922006321	ligand binding site [chemical binding]; other site
205922006322	flexible hinge region; other site
205922006323	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
205922006324	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922006325	LysR family transcriptional regulator; Provisional; Region: PRK14997
205922006326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006327	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922006328	putative effector binding pocket; other site
205922006329	dimerization interface [polypeptide binding]; other site
205922006330	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
205922006331	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922006332	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922006333	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
205922006334	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
205922006335	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
205922006336	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922006337	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922006338	catalytic residue [active]
205922006339	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
205922006340	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
205922006341	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
205922006342	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
205922006343	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
205922006344	Cu(I) binding site [ion binding]; other site
205922006345	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
205922006346	Cu(I) binding site [ion binding]; other site
205922006347	Cytochrome c; Region: Cytochrom_C; pfam00034
205922006348	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
205922006349	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
205922006350	SurA N-terminal domain; Region: SurA_N_3; cl07813
205922006351	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
205922006352	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922006353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922006354	active site
205922006355	phosphorylation site [posttranslational modification]
205922006356	intermolecular recognition site; other site
205922006357	dimerization interface [polypeptide binding]; other site
205922006358	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
205922006359	type II secretion system protein E; Region: type_II_gspE; TIGR02533
205922006360	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
205922006361	Walker A motif; other site
205922006362	ATP binding site [chemical binding]; other site
205922006363	Walker B motif; other site
205922006364	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
205922006365	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
205922006366	TPR repeat; Region: TPR_11; pfam13414
205922006367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
205922006368	binding surface
205922006369	TPR motif; other site
205922006370	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
205922006371	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
205922006372	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
205922006373	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
205922006374	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
205922006375	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
205922006376	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
205922006377	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
205922006378	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
205922006379	curli assembly protein CsgE; Provisional; Region: PRK10386
205922006380	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
205922006381	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
205922006382	major curlin subunit; Provisional; Region: csgA; PRK10051
205922006383	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
205922006384	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
205922006385	Curlin associated repeat; Region: Curlin_rpt; pfam07012
205922006386	sensor protein ZraS; Provisional; Region: PRK10364
205922006387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922006388	dimer interface [polypeptide binding]; other site
205922006389	phosphorylation site [posttranslational modification]
205922006390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922006391	ATP binding site [chemical binding]; other site
205922006392	Mg2+ binding site [ion binding]; other site
205922006393	G-X-G motif; other site
205922006394	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
205922006395	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
205922006396	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
205922006397	Cu(I) binding site [ion binding]; other site
205922006398	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922006399	Cytochrome c; Region: Cytochrom_C; pfam00034
205922006400	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922006401	dimer interface [polypeptide binding]; other site
205922006402	phosphorylation site [posttranslational modification]
205922006403	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
205922006404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922006405	ATP binding site [chemical binding]; other site
205922006406	Mg2+ binding site [ion binding]; other site
205922006407	G-X-G motif; other site
205922006408	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922006409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922006410	active site
205922006411	phosphorylation site [posttranslational modification]
205922006412	intermolecular recognition site; other site
205922006413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922006414	Walker A motif; other site
205922006415	ATP binding site [chemical binding]; other site
205922006416	Walker B motif; other site
205922006417	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922006418	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922006419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922006420	S-adenosylmethionine binding site [chemical binding]; other site
205922006421	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
205922006422	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
205922006423	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
205922006424	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
205922006425	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
205922006426	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
205922006427	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
205922006428	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
205922006429	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
205922006430	putative active site [active]
205922006431	putative metal binding site [ion binding]; other site
205922006432	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
205922006433	putative active site [active]
205922006434	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
205922006435	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922006436	DXD motif; other site
205922006437	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
205922006438	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922006439	active site
205922006440	O-Antigen ligase; Region: Wzy_C; pfam04932
205922006441	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
205922006442	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922006443	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
205922006444	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
205922006445	Chain length determinant protein; Region: Wzz; cl15801
205922006446	Chain length determinant protein; Region: Wzz; cl15801
205922006447	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
205922006448	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
205922006449	SLBB domain; Region: SLBB; pfam10531
205922006450	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
205922006451	Bacterial sugar transferase; Region: Bac_transf; pfam02397
205922006452	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
205922006453	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
205922006454	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
205922006455	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
205922006456	Sulfatase; Region: Sulfatase; cl17466
205922006457	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205922006458	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205922006459	Walker A/P-loop; other site
205922006460	ATP binding site [chemical binding]; other site
205922006461	Q-loop/lid; other site
205922006462	ABC transporter signature motif; other site
205922006463	Walker B; other site
205922006464	D-loop; other site
205922006465	H-loop/switch region; other site
205922006466	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205922006467	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
205922006468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
205922006469	putative transposase OrfB; Reviewed; Region: PHA02517
205922006470	Integrase core domain; Region: rve; pfam00665
205922006471	Integrase core domain; Region: rve_3; pfam13683
205922006472	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922006473	active site
205922006474	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
205922006475	VanW like protein; Region: VanW; pfam04294
205922006476	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
205922006477	RNAase interaction site [polypeptide binding]; other site
205922006478	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
205922006479	active site
205922006480	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922006481	RHS Repeat; Region: RHS_repeat; pfam05593
205922006482	RHS Repeat; Region: RHS_repeat; pfam05593
205922006483	RHS Repeat; Region: RHS_repeat; pfam05593
205922006484	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
205922006485	RHS Repeat; Region: RHS_repeat; pfam05593
205922006486	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
205922006487	RHS Repeat; Region: RHS_repeat; pfam05593
205922006488	RHS Repeat; Region: RHS_repeat; pfam05593
205922006489	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
205922006490	RHS protein; Region: RHS; pfam03527
205922006491	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922006492	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
205922006493	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922006494	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922006495	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922006496	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
205922006497	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
205922006498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
205922006499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922006500	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
205922006501	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
205922006502	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
205922006503	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
205922006504	MASE2 domain; Region: MASE2; pfam05230
205922006505	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922006506	metal binding site [ion binding]; metal-binding site
205922006507	active site
205922006508	I-site; other site
205922006509	glutamate carboxypeptidase; Reviewed; Region: PRK06133
205922006510	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
205922006511	metal binding site [ion binding]; metal-binding site
205922006512	dimer interface [polypeptide binding]; other site
205922006513	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
205922006514	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
205922006515	tetramer interface [polypeptide binding]; other site
205922006516	active site
205922006517	Mg2+/Mn2+ binding site [ion binding]; other site
205922006518	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
205922006519	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
205922006520	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
205922006521	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
205922006522	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
205922006523	N-formylglutamate amidohydrolase; Region: FGase; cl01522
205922006524	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922006525	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922006526	Isochorismatase family; Region: Isochorismatase; pfam00857
205922006527	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
205922006528	catalytic triad [active]
205922006529	conserved cis-peptide bond; other site
205922006530	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
205922006531	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
205922006532	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
205922006533	putative active site [active]
205922006534	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
205922006535	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
205922006536	active site
205922006537	SAM binding site [chemical binding]; other site
205922006538	homodimer interface [polypeptide binding]; other site
205922006539	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
205922006540	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922006541	conserved cys residue [active]
205922006542	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006544	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
205922006545	active site residue [active]
205922006546	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
205922006547	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922006548	substrate binding pocket [chemical binding]; other site
205922006549	membrane-bound complex binding site; other site
205922006550	hinge residues; other site
205922006551	Predicted deacylase [General function prediction only]; Region: COG3608
205922006552	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
205922006553	active site
205922006554	Zn binding site [ion binding]; other site
205922006555	putative hydrolase; Provisional; Region: PRK11460
205922006556	Predicted esterase [General function prediction only]; Region: COG0400
205922006557	manganese transport protein MntH; Reviewed; Region: PRK00701
205922006558	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
205922006559	LysR family transcriptional regulator; Provisional; Region: PRK14997
205922006560	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006561	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922006562	putative effector binding pocket; other site
205922006563	dimerization interface [polypeptide binding]; other site
205922006564	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
205922006565	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
205922006566	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
205922006567	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
205922006568	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922006569	dimer interface [polypeptide binding]; other site
205922006570	active site
205922006571	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
205922006572	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
205922006573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922006574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006575	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
205922006576	putative dimerization interface [polypeptide binding]; other site
205922006577	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
205922006578	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
205922006579	NAD+ binding site [chemical binding]; other site
205922006580	substrate binding site [chemical binding]; other site
205922006581	Zn binding site [ion binding]; other site
205922006582	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922006583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922006584	S-adenosylmethionine binding site [chemical binding]; other site
205922006585	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
205922006586	hypothetical protein; Provisional; Region: PRK05409
205922006587	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
205922006588	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
205922006589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922006590	HAMP domain; Region: HAMP; pfam00672
205922006591	dimerization interface [polypeptide binding]; other site
205922006592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
205922006593	dimer interface [polypeptide binding]; other site
205922006594	phosphorylation site [posttranslational modification]
205922006595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922006596	Mg2+ binding site [ion binding]; other site
205922006597	G-X-G motif; other site
205922006598	osmolarity response regulator; Provisional; Region: ompR; PRK09468
205922006599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922006600	active site
205922006601	phosphorylation site [posttranslational modification]
205922006602	intermolecular recognition site; other site
205922006603	dimerization interface [polypeptide binding]; other site
205922006604	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922006605	DNA binding site [nucleotide binding]
205922006606	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922006607	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
205922006608	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
205922006609	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
205922006610	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205922006611	catalytic residues [active]
205922006612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922006613	Coenzyme A binding pocket [chemical binding]; other site
205922006614	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
205922006615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922006616	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
205922006617	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
205922006618	Protein of unknown function (DUF533); Region: DUF533; pfam04391
205922006619	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
205922006620	putative metal binding site [ion binding]; other site
205922006621	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
205922006622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922006623	S-adenosylmethionine binding site [chemical binding]; other site
205922006624	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
205922006625	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
205922006626	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
205922006627	active site
205922006628	DNA binding site [nucleotide binding]
205922006629	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
205922006630	DNA binding site [nucleotide binding]
205922006631	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
205922006632	nucleotide binding site [chemical binding]; other site
205922006633	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
205922006634	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922006635	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922006636	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922006637	dimerization interface [polypeptide binding]; other site
205922006638	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922006639	dimer interface [polypeptide binding]; other site
205922006640	putative CheW interface [polypeptide binding]; other site
205922006641	malate:quinone oxidoreductase; Validated; Region: PRK05257
205922006642	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
205922006643	SnoaL-like domain; Region: SnoaL_2; pfam12680
205922006644	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
205922006645	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
205922006646	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
205922006647	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922006648	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922006649	active site
205922006650	catalytic tetrad [active]
205922006651	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922006652	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922006653	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922006654	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
205922006655	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
205922006656	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
205922006657	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922006658	catalytic loop [active]
205922006659	iron binding site [ion binding]; other site
205922006660	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922006661	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
205922006662	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
205922006663	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
205922006664	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
205922006665	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922006666	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922006667	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922006668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922006669	dimer interface [polypeptide binding]; other site
205922006670	conserved gate region; other site
205922006671	putative PBP binding loops; other site
205922006672	ABC-ATPase subunit interface; other site
205922006673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922006674	dimer interface [polypeptide binding]; other site
205922006675	conserved gate region; other site
205922006676	putative PBP binding loops; other site
205922006677	ABC-ATPase subunit interface; other site
205922006678	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
205922006679	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922006680	Walker A/P-loop; other site
205922006681	ATP binding site [chemical binding]; other site
205922006682	Q-loop/lid; other site
205922006683	ABC transporter signature motif; other site
205922006684	Walker B; other site
205922006685	D-loop; other site
205922006686	H-loop/switch region; other site
205922006687	TOBE domain; Region: TOBE_2; pfam08402
205922006688	Peptidase C26; Region: Peptidase_C26; pfam07722
205922006689	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
205922006690	catalytic triad [active]
205922006691	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922006692	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922006693	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
205922006694	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
205922006695	NAD(P) binding site [chemical binding]; other site
205922006696	catalytic residues [active]
205922006697	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922006698	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922006699	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
205922006700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922006701	non-specific DNA binding site [nucleotide binding]; other site
205922006702	salt bridge; other site
205922006703	sequence-specific DNA binding site [nucleotide binding]; other site
205922006704	Cupin domain; Region: Cupin_2; pfam07883
205922006705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
205922006706	putative transposase OrfB; Reviewed; Region: PHA02517
205922006707	Integrase core domain; Region: rve; pfam00665
205922006708	Integrase core domain; Region: rve_3; pfam13683
205922006709	HD domain; Region: HD_4; pfam13328
205922006710	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
205922006711	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
205922006712	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
205922006713	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
205922006714	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
205922006715	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
205922006716	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922006717	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922006718	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
205922006719	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
205922006720	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
205922006721	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
205922006722	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922006723	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922006724	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922006725	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922006726	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
205922006727	Chromate transporter; Region: Chromate_transp; pfam02417
205922006728	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
205922006729	MoaE homodimer interface [polypeptide binding]; other site
205922006730	MoaD interaction [polypeptide binding]; other site
205922006731	active site residues [active]
205922006732	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
205922006733	MoaE interaction surface [polypeptide binding]; other site
205922006734	MoeB interaction surface [polypeptide binding]; other site
205922006735	thiocarboxylated glycine; other site
205922006736	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
205922006737	trimer interface [polypeptide binding]; other site
205922006738	dimer interface [polypeptide binding]; other site
205922006739	putative active site [active]
205922006740	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
205922006741	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922006742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006743	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922006744	dimerization interface [polypeptide binding]; other site
205922006745	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
205922006746	MPT binding site; other site
205922006747	trimer interface [polypeptide binding]; other site
205922006748	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
205922006749	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
205922006750	dimer interface [polypeptide binding]; other site
205922006751	putative functional site; other site
205922006752	putative MPT binding site; other site
205922006753	Uncharacterized conserved protein [Function unknown]; Region: COG3791
205922006754	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922006755	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006756	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922006757	dimerization interface [polypeptide binding]; other site
205922006758	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
205922006759	agmatine deiminase; Region: agmatine_aguA; TIGR03380
205922006760	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922006761	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922006762	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
205922006763	endonuclease III; Region: ENDO3c; smart00478
205922006764	minor groove reading motif; other site
205922006765	helix-hairpin-helix signature motif; other site
205922006766	substrate binding pocket [chemical binding]; other site
205922006767	active site
205922006768	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
205922006769	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
205922006770	tetramer interface [polypeptide binding]; other site
205922006771	active site
205922006772	Mg2+/Mn2+ binding site [ion binding]; other site
205922006773	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
205922006774	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
205922006775	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
205922006776	DNA binding site [nucleotide binding]
205922006777	active site
205922006778	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
205922006779	dimer interface [polypeptide binding]; other site
205922006780	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922006781	metal binding site [ion binding]; metal-binding site
205922006782	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922006783	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
205922006784	heme binding pocket [chemical binding]; other site
205922006785	heme ligand [chemical binding]; other site
205922006786	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
205922006787	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
205922006788	putative active site [active]
205922006789	heme pocket [chemical binding]; other site
205922006790	GAF domain; Region: GAF; pfam01590
205922006791	Phytochrome region; Region: PHY; pfam00360
205922006792	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922006793	dimer interface [polypeptide binding]; other site
205922006794	phosphorylation site [posttranslational modification]
205922006795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922006796	ATP binding site [chemical binding]; other site
205922006797	Mg2+ binding site [ion binding]; other site
205922006798	G-X-G motif; other site
205922006799	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
205922006800	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
205922006801	conserved cys residue [active]
205922006802	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922006803	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922006804	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006805	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922006806	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922006807	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
205922006808	dimer interface [polypeptide binding]; other site
205922006809	NnrS protein; Region: NnrS; pfam05940
205922006810	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922006811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922006812	S-adenosylmethionine binding site [chemical binding]; other site
205922006813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922006814	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922006815	metal binding site [ion binding]; metal-binding site
205922006816	active site
205922006817	I-site; other site
205922006818	Uncharacterized conserved protein [Function unknown]; Region: COG3791
205922006819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922006820	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922006821	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922006822	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
205922006823	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922006824	catalytic loop [active]
205922006825	iron binding site [ion binding]; other site
205922006826	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922006827	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922006828	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922006829	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922006830	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922006831	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922006832	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
205922006833	GAF domain; Region: GAF; pfam01590
205922006834	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922006835	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922006836	metal binding site [ion binding]; metal-binding site
205922006837	active site
205922006838	I-site; other site
205922006839	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
205922006840	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
205922006841	NAD binding site [chemical binding]; other site
205922006842	homotetramer interface [polypeptide binding]; other site
205922006843	homodimer interface [polypeptide binding]; other site
205922006844	substrate binding site [chemical binding]; other site
205922006845	active site
205922006846	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
205922006847	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922006848	Walker A/P-loop; other site
205922006849	ATP binding site [chemical binding]; other site
205922006850	Q-loop/lid; other site
205922006851	ABC transporter signature motif; other site
205922006852	Walker B; other site
205922006853	D-loop; other site
205922006854	H-loop/switch region; other site
205922006855	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
205922006856	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922006857	Walker A/P-loop; other site
205922006858	ATP binding site [chemical binding]; other site
205922006859	Q-loop/lid; other site
205922006860	ABC transporter signature motif; other site
205922006861	Walker B; other site
205922006862	D-loop; other site
205922006863	H-loop/switch region; other site
205922006864	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922006865	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
205922006866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922006867	dimer interface [polypeptide binding]; other site
205922006868	conserved gate region; other site
205922006869	putative PBP binding loops; other site
205922006870	ABC-ATPase subunit interface; other site
205922006871	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
205922006872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922006873	dimer interface [polypeptide binding]; other site
205922006874	conserved gate region; other site
205922006875	putative PBP binding loops; other site
205922006876	ABC-ATPase subunit interface; other site
205922006877	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205922006878	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
205922006879	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205922006880	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
205922006881	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
205922006882	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922006883	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922006884	catalytic residue [active]
205922006885	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922006886	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
205922006887	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
205922006888	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922006889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922006890	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
205922006891	RNA/DNA hybrid binding site [nucleotide binding]; other site
205922006892	active site
205922006893	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
205922006894	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
205922006895	active site
205922006896	catalytic site [active]
205922006897	substrate binding site [chemical binding]; other site
205922006898	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
205922006899	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
205922006900	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
205922006901	homodimer interface [polypeptide binding]; other site
205922006902	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922006903	catalytic residue [active]
205922006904	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
205922006905	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
205922006906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922006907	Coenzyme A binding pocket [chemical binding]; other site
205922006908	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
205922006909	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922006910	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922006911	dimerization interface [polypeptide binding]; other site
205922006912	Predicted flavoprotein [General function prediction only]; Region: COG0431
205922006913	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922006914	arsenical pump membrane protein; Provisional; Region: PRK15445
205922006915	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
205922006916	transmembrane helices; other site
205922006917	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
205922006918	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
205922006919	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
205922006920	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
205922006921	active site
205922006922	metal binding site [ion binding]; metal-binding site
205922006923	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
205922006924	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
205922006925	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
205922006926	aminopeptidase N; Provisional; Region: pepN; PRK14015
205922006927	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
205922006928	active site
205922006929	Zn binding site [ion binding]; other site
205922006930	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
205922006931	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
205922006932	dimer interface [polypeptide binding]; other site
205922006933	active site
205922006934	heme binding site [chemical binding]; other site
205922006935	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
205922006936	Sulfatase; Region: Sulfatase; pfam00884
205922006937	NMT1-like family; Region: NMT1_2; pfam13379
205922006938	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
205922006939	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
205922006940	Protein of unknown function (DUF461); Region: DUF461; pfam04314
205922006941	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
205922006942	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
205922006943	Cu(I) binding site [ion binding]; other site
205922006944	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922006945	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
205922006946	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922006947	DNA binding residues [nucleotide binding]
205922006948	dimerization interface [polypeptide binding]; other site
205922006949	Condensation domain; Region: Condensation; pfam00668
205922006950	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006951	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922006952	acyl-activating enzyme (AAE) consensus motif; other site
205922006953	AMP binding site [chemical binding]; other site
205922006954	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006955	Condensation domain; Region: Condensation; pfam00668
205922006956	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006957	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922006958	acyl-activating enzyme (AAE) consensus motif; other site
205922006959	AMP binding site [chemical binding]; other site
205922006960	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006961	Condensation domain; Region: Condensation; pfam00668
205922006962	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922006963	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006964	acyl-activating enzyme (AAE) consensus motif; other site
205922006965	AMP binding site [chemical binding]; other site
205922006966	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006967	Condensation domain; Region: Condensation; pfam00668
205922006968	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
205922006969	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922006970	acyl-activating enzyme (AAE) consensus motif; other site
205922006971	AMP binding site [chemical binding]; other site
205922006972	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006973	Condensation domain; Region: Condensation; pfam00668
205922006974	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006975	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922006976	acyl-activating enzyme (AAE) consensus motif; other site
205922006977	AMP binding site [chemical binding]; other site
205922006978	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006979	Condensation domain; Region: Condensation; pfam00668
205922006980	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922006981	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006982	acyl-activating enzyme (AAE) consensus motif; other site
205922006983	AMP binding site [chemical binding]; other site
205922006984	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006985	Condensation domain; Region: Condensation; pfam00668
205922006986	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922006987	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006988	acyl-activating enzyme (AAE) consensus motif; other site
205922006989	AMP binding site [chemical binding]; other site
205922006990	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006991	Condensation domain; Region: Condensation; pfam00668
205922006992	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922006993	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922006994	acyl-activating enzyme (AAE) consensus motif; other site
205922006995	AMP binding site [chemical binding]; other site
205922006996	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922006997	Condensation domain; Region: Condensation; pfam00668
205922006998	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922006999	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922007000	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922007001	acyl-activating enzyme (AAE) consensus motif; other site
205922007002	AMP binding site [chemical binding]; other site
205922007003	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007004	Condensation domain; Region: Condensation; pfam00668
205922007005	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922007006	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922007007	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922007008	acyl-activating enzyme (AAE) consensus motif; other site
205922007009	AMP binding site [chemical binding]; other site
205922007010	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007011	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
205922007012	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
205922007013	acyl-activating enzyme (AAE) consensus motif; other site
205922007014	AMP binding site [chemical binding]; other site
205922007015	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007016	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
205922007017	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
205922007018	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922007019	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922007020	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
205922007021	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205922007022	Walker A/P-loop; other site
205922007023	ATP binding site [chemical binding]; other site
205922007024	Q-loop/lid; other site
205922007025	ABC transporter signature motif; other site
205922007026	Walker B; other site
205922007027	D-loop; other site
205922007028	H-loop/switch region; other site
205922007029	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205922007030	FtsX-like permease family; Region: FtsX; pfam02687
205922007031	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922007032	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
205922007033	DNA binding residues [nucleotide binding]
205922007034	dimerization interface [polypeptide binding]; other site
205922007035	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
205922007036	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
205922007037	Cysteine-rich domain; Region: CCG; pfam02754
205922007038	Cysteine-rich domain; Region: CCG; pfam02754
205922007039	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
205922007040	FAD binding domain; Region: FAD_binding_4; pfam01565
205922007041	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
205922007042	FAD binding domain; Region: FAD_binding_4; pfam01565
205922007043	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922007044	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
205922007045	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
205922007046	putative S-transferase; Provisional; Region: PRK11752
205922007047	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
205922007048	C-terminal domain interface [polypeptide binding]; other site
205922007049	GSH binding site (G-site) [chemical binding]; other site
205922007050	dimer interface [polypeptide binding]; other site
205922007051	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
205922007052	dimer interface [polypeptide binding]; other site
205922007053	N-terminal domain interface [polypeptide binding]; other site
205922007054	active site
205922007055	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922007056	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007058	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
205922007059	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
205922007060	tetramer interface [polypeptide binding]; other site
205922007061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922007062	catalytic residue [active]
205922007063	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922007064	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
205922007065	active site
205922007066	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
205922007067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922007068	S-adenosylmethionine binding site [chemical binding]; other site
205922007069	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
205922007070	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922007071	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
205922007072	FMN binding site [chemical binding]; other site
205922007073	active site
205922007074	substrate binding site [chemical binding]; other site
205922007075	catalytic residue [active]
205922007076	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
205922007077	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
205922007078	potential catalytic triad [active]
205922007079	conserved cys residue [active]
205922007080	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922007081	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922007082	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922007083	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922007084	N-terminal plug; other site
205922007085	ligand-binding site [chemical binding]; other site
205922007086	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205922007087	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
205922007088	putative ligand binding site [chemical binding]; other site
205922007089	NAD binding site [chemical binding]; other site
205922007090	catalytic site [active]
205922007091	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
205922007092	classical (c) SDRs; Region: SDR_c; cd05233
205922007093	NAD(P) binding site [chemical binding]; other site
205922007094	active site
205922007095	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
205922007096	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
205922007097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007098	D-galactonate transporter; Region: 2A0114; TIGR00893
205922007099	putative substrate translocation pore; other site
205922007100	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922007101	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007102	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
205922007103	NADP binding site [chemical binding]; other site
205922007104	active site
205922007105	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
205922007106	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
205922007107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007109	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
205922007110	putative dimerization interface [polypeptide binding]; other site
205922007111	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
205922007112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922007113	putative metal binding site [ion binding]; other site
205922007114	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
205922007115	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922007116	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922007117	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
205922007118	FMN binding site [chemical binding]; other site
205922007119	active site
205922007120	substrate binding site [chemical binding]; other site
205922007121	catalytic residue [active]
205922007122	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
205922007123	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205922007124	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922007125	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922007126	Walker A/P-loop; other site
205922007127	ATP binding site [chemical binding]; other site
205922007128	Q-loop/lid; other site
205922007129	ABC transporter signature motif; other site
205922007130	Walker B; other site
205922007131	D-loop; other site
205922007132	H-loop/switch region; other site
205922007133	chaperone protein HchA; Provisional; Region: PRK04155
205922007134	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
205922007135	conserved cys residue [active]
205922007136	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
205922007137	Autoinducer binding domain; Region: Autoind_bind; pfam03472
205922007138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922007139	DNA binding residues [nucleotide binding]
205922007140	dimerization interface [polypeptide binding]; other site
205922007141	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922007142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922007143	DNA binding site [nucleotide binding]
205922007144	Predicted ATPase [General function prediction only]; Region: COG3903
205922007145	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922007146	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
205922007147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922007148	active site
205922007149	phosphorylation site [posttranslational modification]
205922007150	intermolecular recognition site; other site
205922007151	dimerization interface [polypeptide binding]; other site
205922007152	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922007153	DNA binding residues [nucleotide binding]
205922007154	dimerization interface [polypeptide binding]; other site
205922007155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922007156	active site
205922007157	phosphorylation site [posttranslational modification]
205922007158	intermolecular recognition site; other site
205922007159	dimerization interface [polypeptide binding]; other site
205922007160	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922007161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922007162	putative active site [active]
205922007163	heme pocket [chemical binding]; other site
205922007164	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922007165	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922007166	putative active site [active]
205922007167	heme pocket [chemical binding]; other site
205922007168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922007169	putative active site [active]
205922007170	heme pocket [chemical binding]; other site
205922007171	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922007172	dimer interface [polypeptide binding]; other site
205922007173	phosphorylation site [posttranslational modification]
205922007174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922007175	ATP binding site [chemical binding]; other site
205922007176	Mg2+ binding site [ion binding]; other site
205922007177	G-X-G motif; other site
205922007178	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922007179	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
205922007180	NADP binding site [chemical binding]; other site
205922007181	dimer interface [polypeptide binding]; other site
205922007182	benzoate transport; Region: 2A0115; TIGR00895
205922007183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007184	Epoxide hydrolase N terminus; Region: EHN; pfam06441
205922007185	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922007186	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922007187	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
205922007188	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922007189	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
205922007190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007191	putative substrate translocation pore; other site
205922007192	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922007193	Helix-turn-helix domain; Region: HTH_18; pfam12833
205922007194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007195	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
205922007196	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
205922007197	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922007198	NAD binding site [chemical binding]; other site
205922007199	catalytic residues [active]
205922007200	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
205922007201	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
205922007202	tetramer interface [polypeptide binding]; other site
205922007203	heme binding pocket [chemical binding]; other site
205922007204	NADPH binding site [chemical binding]; other site
205922007205	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
205922007206	RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989
205922007207	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922007208	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922007209	acyl-activating enzyme (AAE) consensus motif; other site
205922007210	AMP binding site [chemical binding]; other site
205922007211	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007212	Condensation domain; Region: Condensation; pfam00668
205922007213	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922007214	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922007215	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922007216	acyl-activating enzyme (AAE) consensus motif; other site
205922007217	AMP binding site [chemical binding]; other site
205922007218	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007219	Condensation domain; Region: Condensation; pfam00668
205922007220	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922007221	Nonribosomal peptide synthase; Region: NRPS; pfam08415
205922007222	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
205922007223	acyl-activating enzyme (AAE) consensus motif; other site
205922007224	AMP binding site [chemical binding]; other site
205922007225	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
205922007226	putative FMN binding site [chemical binding]; other site
205922007227	NADPH bind site [chemical binding]; other site
205922007228	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
205922007229	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922007230	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922007231	acyl-activating enzyme (AAE) consensus motif; other site
205922007232	AMP binding site [chemical binding]; other site
205922007233	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007234	Thioesterase domain; Region: Thioesterase; pfam00975
205922007235	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
205922007236	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
205922007237	acyl-activating enzyme (AAE) consensus motif; other site
205922007238	AMP binding site [chemical binding]; other site
205922007239	Condensation domain; Region: Condensation; pfam00668
205922007240	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
205922007241	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922007242	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922007243	acyl-activating enzyme (AAE) consensus motif; other site
205922007244	AMP binding site [chemical binding]; other site
205922007245	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007246	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
205922007247	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
205922007248	active site
205922007249	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
205922007250	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
205922007251	putative NADP binding site [chemical binding]; other site
205922007252	active site
205922007253	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922007254	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
205922007255	MbtH-like protein; Region: MbtH; cl01279
205922007256	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
205922007257	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
205922007258	GSCFA family; Region: GSCFA; pfam08885
205922007259	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922007260	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
205922007261	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
205922007262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922007263	NADH(P)-binding; Region: NAD_binding_10; pfam13460
205922007264	NAD(P) binding site [chemical binding]; other site
205922007265	active site
205922007266	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922007267	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922007268	DNA binding site [nucleotide binding]
205922007269	Predicted integral membrane protein [Function unknown]; Region: COG5616
205922007270	TPR repeat; Region: TPR_11; pfam13414
205922007271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922007272	TPR motif; other site
205922007273	binding surface
205922007274	TPR repeat; Region: TPR_11; pfam13414
205922007275	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
205922007276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922007277	active site
205922007278	phosphorylation site [posttranslational modification]
205922007279	intermolecular recognition site; other site
205922007280	dimerization interface [polypeptide binding]; other site
205922007281	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922007282	DNA binding residues [nucleotide binding]
205922007283	dimerization interface [polypeptide binding]; other site
205922007284	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
205922007285	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
205922007286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007288	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922007289	dimerization interface [polypeptide binding]; other site
205922007290	S-type Pyocin; Region: Pyocin_S; pfam06958
205922007291	Cytotoxic; Region: Cytotoxic; pfam09000
205922007292	Cloacin immunity protein; Region: Cloacin_immun; pfam03513
205922007293	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
205922007294	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922007295	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922007296	AAA domain; Region: AAA_21; pfam13304
205922007297	Walker A/P-loop; other site
205922007298	ATP binding site [chemical binding]; other site
205922007299	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922007300	Walker B; other site
205922007301	D-loop; other site
205922007302	H-loop/switch region; other site
205922007303	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
205922007304	active site
205922007305	catalytic residues [active]
205922007306	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
205922007307	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
205922007308	Cache domain; Region: Cache_1; pfam02743
205922007309	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922007310	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922007311	metal binding site [ion binding]; metal-binding site
205922007312	active site
205922007313	I-site; other site
205922007314	methionine sulfoxide reductase A; Provisional; Region: PRK14054
205922007315	Cache domain; Region: Cache_1; pfam02743
205922007316	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922007317	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922007318	metal binding site [ion binding]; metal-binding site
205922007319	active site
205922007320	I-site; other site
205922007321	Isochorismatase family; Region: Isochorismatase; pfam00857
205922007322	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
205922007323	catalytic triad [active]
205922007324	dimer interface [polypeptide binding]; other site
205922007325	conserved cis-peptide bond; other site
205922007326	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
205922007327	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922007328	putative NAD(P) binding site [chemical binding]; other site
205922007329	Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172
205922007330	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
205922007331	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922007332	TM-ABC transporter signature motif; other site
205922007333	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
205922007334	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205922007335	Walker A/P-loop; other site
205922007336	ATP binding site [chemical binding]; other site
205922007337	Q-loop/lid; other site
205922007338	ABC transporter signature motif; other site
205922007339	Walker B; other site
205922007340	D-loop; other site
205922007341	H-loop/switch region; other site
205922007342	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205922007343	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
205922007344	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
205922007345	putative ligand binding site [chemical binding]; other site
205922007346	xylose isomerase; Provisional; Region: PRK05474
205922007347	xylose isomerase; Region: xylose_isom_A; TIGR02630
205922007348	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
205922007349	putative dimerization interface [polypeptide binding]; other site
205922007350	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205922007351	putative ligand binding site [chemical binding]; other site
205922007352	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922007353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007354	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
205922007355	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922007356	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
205922007357	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
205922007358	dimer interface [polypeptide binding]; other site
205922007359	NADP binding site [chemical binding]; other site
205922007360	catalytic residues [active]
205922007361	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
205922007362	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
205922007363	inhibitor site; inhibition site
205922007364	active site
205922007365	dimer interface [polypeptide binding]; other site
205922007366	catalytic residue [active]
205922007367	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
205922007368	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
205922007369	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
205922007370	PAS fold; Region: PAS_4; pfam08448
205922007371	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922007372	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007373	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
205922007374	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
205922007375	dimer interface [polypeptide binding]; other site
205922007376	active site
205922007377	glycine-pyridoxal phosphate binding site [chemical binding]; other site
205922007378	folate binding site [chemical binding]; other site
205922007379	threonine synthase; Validated; Region: PRK06260
205922007380	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
205922007381	homodimer interface [polypeptide binding]; other site
205922007382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922007383	catalytic residue [active]
205922007384	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
205922007385	homotrimer interaction site [polypeptide binding]; other site
205922007386	putative active site [active]
205922007387	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922007388	benzoate transporter; Region: benE; TIGR00843
205922007389	Benzoate membrane transport protein; Region: BenE; pfam03594
205922007390	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922007391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922007392	DNA-binding site [nucleotide binding]; DNA binding site
205922007393	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922007394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922007395	homodimer interface [polypeptide binding]; other site
205922007396	catalytic residue [active]
205922007397	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
205922007398	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
205922007399	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922007400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007401	Helix-turn-helix domain; Region: HTH_18; pfam12833
205922007402	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
205922007403	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
205922007404	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
205922007405	putative alpha subunit interface [polypeptide binding]; other site
205922007406	putative active site [active]
205922007407	putative substrate binding site [chemical binding]; other site
205922007408	Fe binding site [ion binding]; other site
205922007409	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
205922007410	inter-subunit interface; other site
205922007411	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
205922007412	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922007413	catalytic loop [active]
205922007414	iron binding site [ion binding]; other site
205922007415	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
205922007416	FAD binding pocket [chemical binding]; other site
205922007417	FAD binding motif [chemical binding]; other site
205922007418	phosphate binding motif [ion binding]; other site
205922007419	beta-alpha-beta structure motif; other site
205922007420	NAD binding pocket [chemical binding]; other site
205922007421	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
205922007422	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
205922007423	putative NAD(P) binding site [chemical binding]; other site
205922007424	active site
205922007425	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
205922007426	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
205922007427	octamer interface [polypeptide binding]; other site
205922007428	active site
205922007429	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
205922007430	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
205922007431	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
205922007432	dimer interface [polypeptide binding]; other site
205922007433	active site
205922007434	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
205922007435	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922007436	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922007437	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922007438	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
205922007439	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
205922007440	RHS Repeat; Region: RHS_repeat; pfam05593
205922007441	RHS Repeat; Region: RHS_repeat; pfam05593
205922007442	RHS Repeat; Region: RHS_repeat; pfam05593
205922007443	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922007444	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
205922007445	RHS Repeat; Region: RHS_repeat; cl11982
205922007446	RHS protein; Region: RHS; pfam03527
205922007447	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922007448	PAAR motif; Region: PAAR_motif; pfam05488
205922007449	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
205922007450	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
205922007451	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
205922007452	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
205922007453	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
205922007454	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922007455	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
205922007456	Walker A/P-loop; other site
205922007457	ATP binding site [chemical binding]; other site
205922007458	Q-loop/lid; other site
205922007459	ABC transporter signature motif; other site
205922007460	Walker B; other site
205922007461	D-loop; other site
205922007462	H-loop/switch region; other site
205922007463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922007464	dimer interface [polypeptide binding]; other site
205922007465	conserved gate region; other site
205922007466	ABC-ATPase subunit interface; other site
205922007467	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
205922007468	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205922007469	Walker A/P-loop; other site
205922007470	ATP binding site [chemical binding]; other site
205922007471	Q-loop/lid; other site
205922007472	ABC transporter signature motif; other site
205922007473	Walker B; other site
205922007474	D-loop; other site
205922007475	H-loop/switch region; other site
205922007476	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205922007477	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922007478	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
205922007479	TM-ABC transporter signature motif; other site
205922007480	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
205922007481	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
205922007482	putative ligand binding site [chemical binding]; other site
205922007483	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
205922007484	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
205922007485	Moco binding site; other site
205922007486	metal coordination site [ion binding]; other site
205922007487	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
205922007488	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922007489	N-terminal plug; other site
205922007490	ligand-binding site [chemical binding]; other site
205922007491	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
205922007492	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
205922007493	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205922007494	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922007495	non-specific DNA binding site [nucleotide binding]; other site
205922007496	salt bridge; other site
205922007497	sequence-specific DNA binding site [nucleotide binding]; other site
205922007498	Cupin domain; Region: Cupin_2; pfam07883
205922007499	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
205922007500	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
205922007501	putative NAD(P) binding site [chemical binding]; other site
205922007502	putative substrate binding site [chemical binding]; other site
205922007503	catalytic Zn binding site [ion binding]; other site
205922007504	structural Zn binding site [ion binding]; other site
205922007505	dimer interface [polypeptide binding]; other site
205922007506	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08412
205922007507	Uncharacterized conserved protein [Function unknown]; Region: COG5649
205922007508	Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913
205922007509	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922007510	FeS/SAM binding site; other site
205922007511	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
205922007512	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
205922007513	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
205922007514	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
205922007515	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
205922007516	Domain of unknown function (DUF1843); Region: DUF1843; pfam08898
205922007517	2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386
205922007518	transcriptional activator TtdR; Provisional; Region: PRK09801
205922007519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007520	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
205922007521	putative effector binding pocket; other site
205922007522	putative dimerization interface [polypeptide binding]; other site
205922007523	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
205922007524	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
205922007525	substrate binding site [chemical binding]; other site
205922007526	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
205922007527	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
205922007528	substrate binding site [chemical binding]; other site
205922007529	ligand binding site [chemical binding]; other site
205922007530	LysR family transcriptional regulator; Provisional; Region: PRK14997
205922007531	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007532	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
205922007533	putative effector binding pocket; other site
205922007534	putative dimerization interface [polypeptide binding]; other site
205922007535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007537	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922007538	putative effector binding pocket; other site
205922007539	dimerization interface [polypeptide binding]; other site
205922007540	choline dehydrogenase; Validated; Region: PRK02106
205922007541	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922007542	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922007543	Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120
205922007544	NAD(P) binding site [chemical binding]; other site
205922007545	catalytic residues [active]
205922007546	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
205922007547	putative heme binding pocket [chemical binding]; other site
205922007548	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922007549	non-specific DNA binding site [nucleotide binding]; other site
205922007550	salt bridge; other site
205922007551	sequence-specific DNA binding site [nucleotide binding]; other site
205922007552	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
205922007553	homotrimer interaction site [polypeptide binding]; other site
205922007554	putative active site [active]
205922007555	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007556	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007557	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
205922007558	putative effector binding pocket; other site
205922007559	putative dimerization interface [polypeptide binding]; other site
205922007560	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922007561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007562	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922007563	dimerization interface [polypeptide binding]; other site
205922007564	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
205922007565	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
205922007566	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
205922007567	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
205922007568	putative active site; other site
205922007569	catalytic triad [active]
205922007570	putative dimer interface [polypeptide binding]; other site
205922007571	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922007572	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922007573	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
205922007574	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
205922007575	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
205922007576	homotrimer interaction site [polypeptide binding]; other site
205922007577	putative active site [active]
205922007578	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205922007579	CoenzymeA binding site [chemical binding]; other site
205922007580	subunit interaction site [polypeptide binding]; other site
205922007581	PHB binding site; other site
205922007582	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922007583	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
205922007584	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
205922007585	Autotransporter beta-domain; Region: Autotransporter; smart00869
205922007586	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922007587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007589	putative substrate translocation pore; other site
205922007590	Protein of unknown function DUF72; Region: DUF72; pfam01904
205922007591	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
205922007592	homotrimer interaction site [polypeptide binding]; other site
205922007593	putative active site [active]
205922007594	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
205922007595	Peptidase family U32; Region: Peptidase_U32; pfam01136
205922007596	Collagenase; Region: DUF3656; pfam12392
205922007597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007598	putative substrate translocation pore; other site
205922007599	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922007600	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
205922007601	conserved cys residue [active]
205922007602	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007603	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922007604	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922007605	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922007606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007607	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922007608	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
205922007609	Family of unknown function (DUF633); Region: DUF633; pfam04816
205922007610	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
205922007611	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
205922007612	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
205922007613	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922007614	Outer membrane efflux protein; Region: OEP; pfam02321
205922007615	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922007616	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922007617	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
205922007618	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
205922007619	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922007620	Low molecular weight phosphatase family; Region: LMWPc; cd00115
205922007621	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
205922007622	active site
205922007623	arsenical pump membrane protein; Provisional; Region: PRK15445
205922007624	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
205922007625	transmembrane helices; other site
205922007626	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922007627	dimerization interface [polypeptide binding]; other site
205922007628	putative DNA binding site [nucleotide binding]; other site
205922007629	putative Zn2+ binding site [ion binding]; other site
205922007630	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922007631	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
205922007632	active site
205922007633	metal binding site [ion binding]; metal-binding site
205922007634	homotetramer interface [polypeptide binding]; other site
205922007635	Hemerythrin-like domain; Region: Hr-like; cd12108
205922007636	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
205922007637	NmrA-like family; Region: NmrA; pfam05368
205922007638	NAD(P) binding site [chemical binding]; other site
205922007639	active site lysine
205922007640	Predicted transcriptional regulators [Transcription]; Region: COG1733
205922007641	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
205922007642	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922007643	MarR family; Region: MarR_2; pfam12802
205922007644	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922007645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922007646	Coenzyme A binding pocket [chemical binding]; other site
205922007647	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
205922007648	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
205922007649	dimerization interface [polypeptide binding]; other site
205922007650	putative catalytic residue [active]
205922007651	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
205922007652	dimer interface [polypeptide binding]; other site
205922007653	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922007654	ligand binding site [chemical binding]; other site
205922007655	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
205922007656	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922007657	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922007658	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
205922007659	LabA_like proteins; Region: LabA_like; cd06167
205922007660	putative metal binding site [ion binding]; other site
205922007661	Uncharacterized conserved protein [Function unknown]; Region: COG1432
205922007662	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922007663	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007664	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007665	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922007666	putative effector binding pocket; other site
205922007667	dimerization interface [polypeptide binding]; other site
205922007668	glutathione S-transferase; Provisional; Region: PRK15113
205922007669	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
205922007670	C-terminal domain interface [polypeptide binding]; other site
205922007671	GSH binding site (G-site) [chemical binding]; other site
205922007672	dimer interface [polypeptide binding]; other site
205922007673	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
205922007674	N-terminal domain interface [polypeptide binding]; other site
205922007675	putative dimer interface [polypeptide binding]; other site
205922007676	putative substrate binding pocket (H-site) [chemical binding]; other site
205922007677	Inclusion body protein; Region: PixA; pfam12306
205922007678	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
205922007679	AAA domain; Region: AAA_23; pfam13476
205922007680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922007681	Walker A/P-loop; other site
205922007682	ATP binding site [chemical binding]; other site
205922007683	Q-loop/lid; other site
205922007684	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
205922007685	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
205922007686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922007687	dimer interface [polypeptide binding]; other site
205922007688	conserved gate region; other site
205922007689	putative PBP binding loops; other site
205922007690	ABC-ATPase subunit interface; other site
205922007691	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
205922007692	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
205922007693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922007694	Walker A/P-loop; other site
205922007695	ATP binding site [chemical binding]; other site
205922007696	Q-loop/lid; other site
205922007697	ABC transporter signature motif; other site
205922007698	Walker B; other site
205922007699	D-loop; other site
205922007700	H-loop/switch region; other site
205922007701	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
205922007702	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922007703	substrate binding pocket [chemical binding]; other site
205922007704	membrane-bound complex binding site; other site
205922007705	hinge residues; other site
205922007706	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
205922007707	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
205922007708	potential catalytic triad [active]
205922007709	conserved cys residue [active]
205922007710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007712	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922007713	putative effector binding pocket; other site
205922007714	dimerization interface [polypeptide binding]; other site
205922007715	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
205922007716	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922007717	putative NAD(P) binding site [chemical binding]; other site
205922007718	substrate binding site [chemical binding]; other site
205922007719	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007720	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007721	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
205922007722	putative effector binding pocket; other site
205922007723	putative dimerization interface [polypeptide binding]; other site
205922007724	short chain dehydrogenase; Provisional; Region: PRK06500
205922007725	classical (c) SDRs; Region: SDR_c; cd05233
205922007726	NAD(P) binding site [chemical binding]; other site
205922007727	active site
205922007728	Paraquat-inducible protein A; Region: PqiA; pfam04403
205922007729	Paraquat-inducible protein A; Region: PqiA; pfam04403
205922007730	glutathionine S-transferase; Provisional; Region: PRK10542
205922007731	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
205922007732	C-terminal domain interface [polypeptide binding]; other site
205922007733	GSH binding site (G-site) [chemical binding]; other site
205922007734	dimer interface [polypeptide binding]; other site
205922007735	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
205922007736	dimer interface [polypeptide binding]; other site
205922007737	N-terminal domain interface [polypeptide binding]; other site
205922007738	substrate binding pocket (H-site) [chemical binding]; other site
205922007739	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922007740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007741	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
205922007742	dimerization interface [polypeptide binding]; other site
205922007743	substrate binding pocket [chemical binding]; other site
205922007744	Cupin domain; Region: Cupin_2; pfam07883
205922007745	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922007746	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
205922007747	FMN binding site [chemical binding]; other site
205922007748	active site
205922007749	substrate binding site [chemical binding]; other site
205922007750	catalytic residue [active]
205922007751	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922007752	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922007753	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922007754	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922007755	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
205922007756	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922007757	catalytic loop [active]
205922007758	iron binding site [ion binding]; other site
205922007759	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922007760	Cytochrome c; Region: Cytochrom_C; pfam00034
205922007761	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922007762	Cytochrome c; Region: Cytochrom_C; pfam00034
205922007763	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922007764	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922007765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007766	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
205922007767	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007768	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007769	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922007770	putative effector binding pocket; other site
205922007771	dimerization interface [polypeptide binding]; other site
205922007772	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
205922007773	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922007774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922007775	Response regulator receiver domain; Region: Response_reg; pfam00072
205922007776	active site
205922007777	phosphorylation site [posttranslational modification]
205922007778	intermolecular recognition site; other site
205922007779	dimerization interface [polypeptide binding]; other site
205922007780	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922007781	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922007782	conserved cys residue [active]
205922007783	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007784	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
205922007785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922007786	active site
205922007787	phosphorylation site [posttranslational modification]
205922007788	intermolecular recognition site; other site
205922007789	dimerization interface [polypeptide binding]; other site
205922007790	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922007791	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
205922007792	conserved cys residue [active]
205922007793	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
205922007794	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922007795	putative active site [active]
205922007796	heme pocket [chemical binding]; other site
205922007797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922007798	dimer interface [polypeptide binding]; other site
205922007799	phosphorylation site [posttranslational modification]
205922007800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922007801	ATP binding site [chemical binding]; other site
205922007802	G-X-G motif; other site
205922007803	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
205922007804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922007805	active site
205922007806	phosphorylation site [posttranslational modification]
205922007807	intermolecular recognition site; other site
205922007808	dimerization interface [polypeptide binding]; other site
205922007809	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922007810	DNA binding residues [nucleotide binding]
205922007811	dimerization interface [polypeptide binding]; other site
205922007812	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
205922007813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922007814	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
205922007815	putative substrate binding pocket [chemical binding]; other site
205922007816	putative dimerization interface [polypeptide binding]; other site
205922007817	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922007818	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922007819	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922007820	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
205922007821	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922007822	N-terminal plug; other site
205922007823	ligand-binding site [chemical binding]; other site
205922007824	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
205922007825	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
205922007826	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922007827	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007828	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007829	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
205922007830	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
205922007831	classical (c) SDRs; Region: SDR_c; cd05233
205922007832	NAD(P) binding site [chemical binding]; other site
205922007833	active site
205922007834	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922007835	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922007836	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007837	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
205922007838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922007839	NAD(P) binding site [chemical binding]; other site
205922007840	active site
205922007841	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922007842	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922007843	Cytochrome c; Region: Cytochrom_C; pfam00034
205922007844	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922007845	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922007846	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922007847	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922007848	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
205922007849	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922007850	catalytic loop [active]
205922007851	iron binding site [ion binding]; other site
205922007852	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922007853	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
205922007854	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922007855	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007856	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922007857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922007858	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922007859	putative substrate translocation pore; other site
205922007860	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922007861	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
205922007862	putative NAD(P) binding site [chemical binding]; other site
205922007863	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922007864	TAP-like protein; Region: Abhydrolase_4; pfam08386
205922007865	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
205922007866	classical (c) SDRs; Region: SDR_c; cd05233
205922007867	NAD(P) binding site [chemical binding]; other site
205922007868	active site
205922007869	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922007870	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
205922007871	FMN binding site [chemical binding]; other site
205922007872	active site
205922007873	substrate binding site [chemical binding]; other site
205922007874	catalytic residue [active]
205922007875	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922007876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922007877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922007878	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
205922007879	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
205922007880	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922007881	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922007882	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
205922007883	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
205922007884	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
205922007885	YccA-like proteins; Region: YccA_like; cd10433
205922007886	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
205922007887	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
205922007888	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
205922007889	AsnC family; Region: AsnC_trans_reg; pfam01037
205922007890	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
205922007891	EamA-like transporter family; Region: EamA; pfam00892
205922007892	EamA-like transporter family; Region: EamA; cl17759
205922007893	Predicted membrane protein [Function unknown]; Region: COG1289
205922007894	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
205922007895	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
205922007896	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922007897	tetrameric interface [polypeptide binding]; other site
205922007898	activator binding site; other site
205922007899	NADP binding site [chemical binding]; other site
205922007900	substrate binding site [chemical binding]; other site
205922007901	catalytic residues [active]
205922007902	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
205922007903	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
205922007904	FAD binding domain; Region: FAD_binding_4; pfam01565
205922007905	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
205922007906	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
205922007907	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814
205922007908	dimer interface [polypeptide binding]; other site
205922007909	active site
205922007910	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922007911	substrate binding site [chemical binding]; other site
205922007912	catalytic residue [active]
205922007913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205922007914	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
205922007915	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
205922007916	Surface antigen; Region: Bac_surface_Ag; pfam01103
205922007917	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
205922007918	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
205922007919	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
205922007920	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
205922007921	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
205922007922	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
205922007923	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
205922007924	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
205922007925	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
205922007926	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
205922007927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922007928	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922007929	putative acetyltransferase YhhY; Provisional; Region: PRK10140
205922007930	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922007931	Coenzyme A binding pocket [chemical binding]; other site
205922007932	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
205922007933	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
205922007934	Low-spin heme binding site [chemical binding]; other site
205922007935	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
205922007936	D-pathway; other site
205922007937	Putative water exit pathway; other site
205922007938	Binuclear center (active site) [active]
205922007939	K-pathway; other site
205922007940	Putative proton exit pathway; other site
205922007941	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
205922007942	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922007943	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922007944	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
205922007945	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
205922007946	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
205922007947	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205922007948	HSP70 interaction site [polypeptide binding]; other site
205922007949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
205922007950	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
205922007951	dimer interface [polypeptide binding]; other site
205922007952	catalytic triad [active]
205922007953	peroxidatic and resolving cysteines [active]
205922007954	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
205922007955	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922007956	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922007957	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
205922007958	Protein export membrane protein; Region: SecD_SecF; cl14618
205922007959	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
205922007960	Protein export membrane protein; Region: SecD_SecF; cl14618
205922007961	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922007962	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
205922007963	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
205922007964	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
205922007965	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922007966	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922007967	metal binding site [ion binding]; metal-binding site
205922007968	active site
205922007969	I-site; other site
205922007970	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922007971	short chain dehydrogenase; Provisional; Region: PRK06123
205922007972	classical (c) SDRs; Region: SDR_c; cd05233
205922007973	NAD(P) binding site [chemical binding]; other site
205922007974	active site
205922007975	Galactose oxidase, central domain; Region: Kelch_3; cl02701
205922007976	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
205922007977	Kelch domain; Region: Kelch; smart00612
205922007978	Galactose oxidase, central domain; Region: Kelch_3; cl02701
205922007979	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
205922007980	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922007981	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922007982	DNA-binding site [nucleotide binding]; DNA binding site
205922007983	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922007984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922007985	homodimer interface [polypeptide binding]; other site
205922007986	catalytic residue [active]
205922007987	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
205922007988	4Fe-4S binding domain; Region: Fer4_5; pfam12801
205922007989	4Fe-4S binding domain; Region: Fer4_3; pfam12798
205922007990	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
205922007991	Protein of unknown function (DUF3203); Region: DUF3203; pfam11462
205922007992	MgtC family; Region: MgtC; pfam02308
205922007993	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
205922007994	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
205922007995	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
205922007996	active site
205922007997	homodimer interface [polypeptide binding]; other site
205922007998	catalytic site [active]
205922007999	acceptor binding site [chemical binding]; other site
205922008000	trehalose synthase; Region: treS_nterm; TIGR02456
205922008001	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
205922008002	active site
205922008003	catalytic site [active]
205922008004	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
205922008005	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
205922008006	glycogen branching enzyme; Provisional; Region: PRK05402
205922008007	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
205922008008	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
205922008009	active site
205922008010	catalytic site [active]
205922008011	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
205922008012	Autotransporter beta-domain; Region: Autotransporter; smart00869
205922008013	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
205922008014	putative catalytic site [active]
205922008015	putative metal binding site [ion binding]; other site
205922008016	putative phosphate binding site [ion binding]; other site
205922008017	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
205922008018	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922008019	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922008020	active site
205922008021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922008022	S-adenosylmethionine binding site [chemical binding]; other site
205922008023	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
205922008024	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922008025	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922008026	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
205922008027	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
205922008028	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
205922008029	active site
205922008030	catalytic site [active]
205922008031	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
205922008032	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
205922008033	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
205922008034	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
205922008035	active site
205922008036	catalytic site [active]
205922008037	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
205922008038	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
205922008039	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
205922008040	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
205922008041	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
205922008042	catalytic site [active]
205922008043	active site
205922008044	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
205922008045	glycogen synthase; Provisional; Region: glgA; PRK00654
205922008046	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
205922008047	ADP-binding pocket [chemical binding]; other site
205922008048	homodimer interface [polypeptide binding]; other site
205922008049	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
205922008050	dimerization interface [polypeptide binding]; other site
205922008051	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205922008052	NAD binding site [chemical binding]; other site
205922008053	ligand binding site [chemical binding]; other site
205922008054	catalytic site [active]
205922008055	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922008056	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
205922008057	Predicted membrane protein [Function unknown]; Region: COG1238
205922008058	Protein of unknown function, DUF; Region: DUF411; cl01142
205922008059	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
205922008060	dimerization interface [polypeptide binding]; other site
205922008061	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922008062	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922008063	dimer interface [polypeptide binding]; other site
205922008064	putative CheW interface [polypeptide binding]; other site
205922008065	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922008066	Coenzyme A binding pocket [chemical binding]; other site
205922008067	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922008068	active site
205922008069	CoA binding site [chemical binding]; other site
205922008070	AMP binding site [chemical binding]; other site
205922008071	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
205922008072	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
205922008073	putative catalytic cysteine [active]
205922008074	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922008075	active site
205922008076	AMP binding site [chemical binding]; other site
205922008077	acyl-activating enzyme (AAE) consensus motif; other site
205922008078	CoA binding site [chemical binding]; other site
205922008079	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
205922008080	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
205922008081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922008082	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
205922008083	Penicillin amidase; Region: Penicil_amidase; pfam01804
205922008084	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
205922008085	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
205922008086	active site
205922008087	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
205922008088	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922008089	FecR protein; Region: FecR; pfam04773
205922008090	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
205922008091	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
205922008092	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
205922008093	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008094	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008095	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
205922008096	putative substrate binding pocket [chemical binding]; other site
205922008097	putative dimerization interface [polypeptide binding]; other site
205922008098	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
205922008099	Predicted amidohydrolase [General function prediction only]; Region: COG0388
205922008100	putative active site [active]
205922008101	catalytic triad [active]
205922008102	putative dimer interface [polypeptide binding]; other site
205922008103	Water Stress and Hypersensitive response; Region: WHy; smart00769
205922008104	xanthine permease; Region: pbuX; TIGR03173
205922008105	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008106	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008107	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922008108	dimerization interface [polypeptide binding]; other site
205922008109	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922008110	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205922008111	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
205922008112	agmatinase; Region: agmatinase; TIGR01230
205922008113	oligomer interface [polypeptide binding]; other site
205922008114	putative active site [active]
205922008115	Mn binding site [ion binding]; other site
205922008116	HTH domain; Region: HTH_11; pfam08279
205922008117	Predicted transcriptional regulator [Transcription]; Region: COG2378
205922008118	WYL domain; Region: WYL; pfam13280
205922008119	SnoaL-like domain; Region: SnoaL_2; pfam12680
205922008120	Predicted ATPase [General function prediction only]; Region: COG1485
205922008121	DinB family; Region: DinB; cl17821
205922008122	DinB superfamily; Region: DinB_2; pfam12867
205922008123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922008124	Coenzyme A binding pocket [chemical binding]; other site
205922008125	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
205922008126	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922008127	N-terminal plug; other site
205922008128	ligand-binding site [chemical binding]; other site
205922008129	hypothetical protein; Provisional; Region: PRK10649
205922008130	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
205922008131	Sulfatase; Region: Sulfatase; pfam00884
205922008132	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
205922008133	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
205922008134	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
205922008135	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
205922008136	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
205922008137	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
205922008138	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922008139	active site
205922008140	motif I; other site
205922008141	motif II; other site
205922008142	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205922008143	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
205922008144	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
205922008145	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
205922008146	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
205922008147	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
205922008148	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922008149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922008150	Walker A motif; other site
205922008151	ATP binding site [chemical binding]; other site
205922008152	Walker B motif; other site
205922008153	arginine finger; other site
205922008154	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922008155	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
205922008156	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
205922008157	putative active site [active]
205922008158	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
205922008159	AAA domain; Region: AAA_28; pfam13521
205922008160	active site
205922008161	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
205922008162	Cache domain; Region: Cache_2; pfam08269
205922008163	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922008164	dimerization interface [polypeptide binding]; other site
205922008165	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922008166	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922008167	dimer interface [polypeptide binding]; other site
205922008168	putative CheW interface [polypeptide binding]; other site
205922008169	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
205922008170	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
205922008171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
205922008172	LysR family transcriptional regulator; Provisional; Region: PRK14997
205922008173	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922008174	dimerization interface [polypeptide binding]; other site
205922008175	azoreductase; Reviewed; Region: PRK00170
205922008176	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922008177	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
205922008178	major facilitator superfamily transporter; Provisional; Region: PRK05122
205922008179	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
205922008180	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922008181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922008182	Walker A/P-loop; other site
205922008183	ATP binding site [chemical binding]; other site
205922008184	ABC transporter signature motif; other site
205922008185	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922008186	Walker B; other site
205922008187	ABC transporter; Region: ABC_tran_2; pfam12848
205922008188	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922008189	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922008190	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
205922008191	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
205922008192	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
205922008193	putative DNA binding site [nucleotide binding]; other site
205922008194	putative homodimer interface [polypeptide binding]; other site
205922008195	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
205922008196	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
205922008197	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205922008198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922008199	Coenzyme A binding pocket [chemical binding]; other site
205922008200	Peptidase_C39 like family; Region: DUF3335; pfam11814
205922008201	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
205922008202	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
205922008203	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205922008204	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
205922008205	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
205922008206	oligomer interface [polypeptide binding]; other site
205922008207	Cl binding site [ion binding]; other site
205922008208	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
205922008209	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
205922008210	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
205922008211	tetramer interface [polypeptide binding]; other site
205922008212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922008213	catalytic residue [active]
205922008214	ecotin; Provisional; Region: PRK03719
205922008215	secondary substrate binding site; other site
205922008216	primary substrate binding site; other site
205922008217	inhibition loop; other site
205922008218	dimerization interface [polypeptide binding]; other site
205922008219	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
205922008220	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922008221	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922008222	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922008223	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922008224	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922008225	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
205922008226	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922008227	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922008228	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922008229	outer membrane porin, OprD family; Region: OprD; pfam03573
205922008230	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922008231	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922008232	catalytic residue [active]
205922008233	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
205922008234	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205922008235	putative substrate binding site [chemical binding]; other site
205922008236	putative ATP binding site [chemical binding]; other site
205922008237	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
205922008238	N- and C-terminal domain interface [polypeptide binding]; other site
205922008239	D-xylulose kinase; Region: XylB; TIGR01312
205922008240	active site
205922008241	MgATP binding site [chemical binding]; other site
205922008242	catalytic site [active]
205922008243	metal binding site [ion binding]; metal-binding site
205922008244	xylulose binding site [chemical binding]; other site
205922008245	putative homodimer interface [polypeptide binding]; other site
205922008246	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
205922008247	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
205922008248	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
205922008249	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
205922008250	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
205922008251	Walker A/P-loop; other site
205922008252	ATP binding site [chemical binding]; other site
205922008253	Q-loop/lid; other site
205922008254	ABC transporter signature motif; other site
205922008255	Walker B; other site
205922008256	D-loop; other site
205922008257	H-loop/switch region; other site
205922008258	TOBE domain; Region: TOBE_2; pfam08402
205922008259	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
205922008260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922008261	dimer interface [polypeptide binding]; other site
205922008262	conserved gate region; other site
205922008263	putative PBP binding loops; other site
205922008264	ABC-ATPase subunit interface; other site
205922008265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922008266	dimer interface [polypeptide binding]; other site
205922008267	conserved gate region; other site
205922008268	putative PBP binding loops; other site
205922008269	ABC-ATPase subunit interface; other site
205922008270	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
205922008271	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
205922008272	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922008273	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922008274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922008275	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922008276	Catalytic domain of bacterial phosphatidylinositol-specific phospholipase C and similar proteins; Region: PI-PLCc_bacteria_like; cd08557
205922008277	active site
205922008278	catalytic site [active]
205922008279	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922008280	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205922008281	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
205922008282	Response regulator receiver domain; Region: Response_reg; pfam00072
205922008283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008284	active site
205922008285	phosphorylation site [posttranslational modification]
205922008286	intermolecular recognition site; other site
205922008287	dimerization interface [polypeptide binding]; other site
205922008288	CHASE3 domain; Region: CHASE3; pfam05227
205922008289	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
205922008290	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
205922008291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008292	dimer interface [polypeptide binding]; other site
205922008293	phosphorylation site [posttranslational modification]
205922008294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008295	ATP binding site [chemical binding]; other site
205922008296	Mg2+ binding site [ion binding]; other site
205922008297	G-X-G motif; other site
205922008298	Response regulator receiver domain; Region: Response_reg; pfam00072
205922008299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008300	active site
205922008301	phosphorylation site [posttranslational modification]
205922008302	intermolecular recognition site; other site
205922008303	dimerization interface [polypeptide binding]; other site
205922008304	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922008305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008306	active site
205922008307	phosphorylation site [posttranslational modification]
205922008308	intermolecular recognition site; other site
205922008309	Response regulator receiver domain; Region: Response_reg; pfam00072
205922008310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008311	active site
205922008312	phosphorylation site [posttranslational modification]
205922008313	intermolecular recognition site; other site
205922008314	dimerization interface [polypeptide binding]; other site
205922008315	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
205922008316	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
205922008317	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
205922008318	CheB methylesterase; Region: CheB_methylest; pfam01339
205922008319	Response regulator receiver domain; Region: Response_reg; pfam00072
205922008320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008321	active site
205922008322	phosphorylation site [posttranslational modification]
205922008323	intermolecular recognition site; other site
205922008324	dimerization interface [polypeptide binding]; other site
205922008325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922008326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008327	dimer interface [polypeptide binding]; other site
205922008328	phosphorylation site [posttranslational modification]
205922008329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008330	ATP binding site [chemical binding]; other site
205922008331	Mg2+ binding site [ion binding]; other site
205922008332	G-X-G motif; other site
205922008333	Response regulator receiver domain; Region: Response_reg; pfam00072
205922008334	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008335	active site
205922008336	phosphorylation site [posttranslational modification]
205922008337	intermolecular recognition site; other site
205922008338	dimerization interface [polypeptide binding]; other site
205922008339	Protein of unknown function (DUF1168); Region: DUF1168; pfam06658
205922008340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008341	ATP binding site [chemical binding]; other site
205922008342	Mg2+ binding site [ion binding]; other site
205922008343	G-X-G motif; other site
205922008344	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922008345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008346	active site
205922008347	phosphorylation site [posttranslational modification]
205922008348	intermolecular recognition site; other site
205922008349	dimerization interface [polypeptide binding]; other site
205922008350	circadian clock protein KaiC; Reviewed; Region: PRK09302
205922008351	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205922008352	Walker A motif; other site
205922008353	ATP binding site [chemical binding]; other site
205922008354	Walker B motif; other site
205922008355	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205922008356	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205922008357	Walker A motif; other site
205922008358	Walker A motif; other site
205922008359	ATP binding site [chemical binding]; other site
205922008360	Walker B motif; other site
205922008361	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
205922008362	Fusaric acid resistance protein family; Region: FUSC; pfam04632
205922008363	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
205922008364	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
205922008365	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922008366	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922008367	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
205922008368	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
205922008369	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922008370	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922008371	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922008372	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
205922008373	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
205922008374	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
205922008375	G1 box; other site
205922008376	GTP/Mg2+ binding site [chemical binding]; other site
205922008377	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
205922008378	G2 box; other site
205922008379	Switch I region; other site
205922008380	G3 box; other site
205922008381	Switch II region; other site
205922008382	GTP/Mg2+ binding site [chemical binding]; other site
205922008383	G4 box; other site
205922008384	G5 box; other site
205922008385	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
205922008386	G1 box; other site
205922008387	GTP/Mg2+ binding site [chemical binding]; other site
205922008388	G2 box; other site
205922008389	Switch I region; other site
205922008390	G3 box; other site
205922008391	Switch II region; other site
205922008392	G4 box; other site
205922008393	G5 box; other site
205922008394	Protein of unknown function (DUF726); Region: DUF726; pfam05277
205922008395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008397	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
205922008398	putative substrate binding pocket [chemical binding]; other site
205922008399	putative dimerization interface [polypeptide binding]; other site
205922008400	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
205922008401	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922008402	putative NAD(P) binding site [chemical binding]; other site
205922008403	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922008404	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922008405	DNA-binding site [nucleotide binding]; DNA binding site
205922008406	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922008407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922008408	homodimer interface [polypeptide binding]; other site
205922008409	catalytic residue [active]
205922008410	phosphoglucomutase; Validated; Region: PRK07564
205922008411	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
205922008412	active site
205922008413	substrate binding site [chemical binding]; other site
205922008414	metal binding site [ion binding]; metal-binding site
205922008415	Pirin-related protein [General function prediction only]; Region: COG1741
205922008416	Pirin; Region: Pirin; pfam02678
205922008417	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
205922008418	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
205922008419	Family description; Region: UvrD_C_2; pfam13538
205922008420	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
205922008421	SnoaL-like domain; Region: SnoaL_2; pfam12680
205922008422	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922008423	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922008424	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922008425	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922008426	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
205922008427	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922008428	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922008429	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
205922008430	active site
205922008431	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922008432	Protease inhibitor Inh; Region: Inh; pfam02974
205922008433	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
205922008434	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
205922008435	Walker A/P-loop; other site
205922008436	ATP binding site [chemical binding]; other site
205922008437	Q-loop/lid; other site
205922008438	ABC transporter signature motif; other site
205922008439	Walker B; other site
205922008440	D-loop; other site
205922008441	H-loop/switch region; other site
205922008442	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
205922008443	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205922008444	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922008445	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
205922008446	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
205922008447	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
205922008448	catalytic triad [active]
205922008449	putative active site [active]
205922008450	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922008451	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
205922008452	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
205922008453	Autotransporter beta-domain; Region: Autotransporter; smart00869
205922008454	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
205922008455	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
205922008456	catalytic triad [active]
205922008457	putative active site [active]
205922008458	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922008459	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
205922008460	Autotransporter beta-domain; Region: Autotransporter; pfam03797
205922008461	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
205922008462	nucleophilic elbow; other site
205922008463	catalytic triad; other site
205922008464	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
205922008465	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
205922008466	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
205922008467	DEAD/DEAH box helicase; Region: DEAD; pfam00270
205922008468	ATP binding site [chemical binding]; other site
205922008469	DEAD_2; Region: DEAD_2; pfam06733
205922008470	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
205922008471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922008472	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922008473	putative active site [active]
205922008474	heme pocket [chemical binding]; other site
205922008475	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922008476	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
205922008477	putative active site [active]
205922008478	heme pocket [chemical binding]; other site
205922008479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008480	dimer interface [polypeptide binding]; other site
205922008481	phosphorylation site [posttranslational modification]
205922008482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008483	ATP binding site [chemical binding]; other site
205922008484	Mg2+ binding site [ion binding]; other site
205922008485	G-X-G motif; other site
205922008486	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922008487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008488	active site
205922008489	phosphorylation site [posttranslational modification]
205922008490	intermolecular recognition site; other site
205922008491	dimerization interface [polypeptide binding]; other site
205922008492	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
205922008493	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
205922008494	Yip1 domain; Region: Yip1; cl17815
205922008495	short chain dehydrogenase; Provisional; Region: PRK06701
205922008496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922008497	NAD(P) binding site [chemical binding]; other site
205922008498	active site
205922008499	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
205922008500	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922008501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922008502	homodimer interface [polypeptide binding]; other site
205922008503	catalytic residue [active]
205922008504	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
205922008505	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
205922008506	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
205922008507	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
205922008508	molybdopterin cofactor binding site; other site
205922008509	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
205922008510	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
205922008511	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
205922008512	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
205922008513	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
205922008514	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
205922008515	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922008516	dimerization interface [polypeptide binding]; other site
205922008517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008518	dimer interface [polypeptide binding]; other site
205922008519	phosphorylation site [posttranslational modification]
205922008520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008521	ATP binding site [chemical binding]; other site
205922008522	Mg2+ binding site [ion binding]; other site
205922008523	G-X-G motif; other site
205922008524	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922008525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008526	active site
205922008527	phosphorylation site [posttranslational modification]
205922008528	intermolecular recognition site; other site
205922008529	dimerization interface [polypeptide binding]; other site
205922008530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922008531	DNA binding site [nucleotide binding]
205922008532	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
205922008533	selenocysteine synthase; Provisional; Region: PRK04311
205922008534	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
205922008535	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
205922008536	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922008537	catalytic residue [active]
205922008538	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
205922008539	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
205922008540	G1 box; other site
205922008541	putative GEF interaction site [polypeptide binding]; other site
205922008542	GTP/Mg2+ binding site [chemical binding]; other site
205922008543	Switch I region; other site
205922008544	G2 box; other site
205922008545	G3 box; other site
205922008546	Switch II region; other site
205922008547	G4 box; other site
205922008548	G5 box; other site
205922008549	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
205922008550	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
205922008551	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
205922008552	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
205922008553	outer membrane porin, OprD family; Region: OprD; pfam03573
205922008554	CHASE4 domain; Region: CHASE4; pfam05228
205922008555	PAS domain S-box; Region: sensory_box; TIGR00229
205922008556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922008557	putative active site [active]
205922008558	heme pocket [chemical binding]; other site
205922008559	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922008560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922008561	metal binding site [ion binding]; metal-binding site
205922008562	active site
205922008563	I-site; other site
205922008564	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922008565	YcaO domain protein; Region: TIGR03549
205922008566	OsmC-like protein; Region: OsmC; pfam02566
205922008567	YcaO-like family; Region: YcaO; pfam02624
205922008568	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
205922008569	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
205922008570	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
205922008571	Trp docking motif [polypeptide binding]; other site
205922008572	putative active site [active]
205922008573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008575	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922008576	putative effector binding pocket; other site
205922008577	dimerization interface [polypeptide binding]; other site
205922008578	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
205922008579	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922008580	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
205922008581	NAD(P) binding site [chemical binding]; other site
205922008582	active site
205922008583	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
205922008584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922008585	NAD(P) binding site [chemical binding]; other site
205922008586	active site
205922008587	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922008588	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922008589	conserved cys residue [active]
205922008590	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922008591	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
205922008592	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
205922008593	PYR/PP interface [polypeptide binding]; other site
205922008594	dimer interface [polypeptide binding]; other site
205922008595	TPP binding site [chemical binding]; other site
205922008596	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205922008597	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
205922008598	TPP-binding site [chemical binding]; other site
205922008599	dimer interface [polypeptide binding]; other site
205922008600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922008601	D-galactonate transporter; Region: 2A0114; TIGR00893
205922008602	putative substrate translocation pore; other site
205922008603	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
205922008604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922008605	NAD(P) binding site [chemical binding]; other site
205922008606	active site
205922008607	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922008608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008609	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
205922008610	dimerization interface [polypeptide binding]; other site
205922008611	substrate binding pocket [chemical binding]; other site
205922008612	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
205922008613	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
205922008614	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008616	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922008617	dimerization interface [polypeptide binding]; other site
205922008618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922008619	putative substrate translocation pore; other site
205922008620	short chain dehydrogenase; Provisional; Region: PRK06500
205922008621	classical (c) SDRs; Region: SDR_c; cd05233
205922008622	NAD(P) binding site [chemical binding]; other site
205922008623	active site
205922008624	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008626	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922008627	dimerization interface [polypeptide binding]; other site
205922008628	xanthine permease; Region: pbuX; TIGR03173
205922008629	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
205922008630	nucleoside/Zn binding site; other site
205922008631	dimer interface [polypeptide binding]; other site
205922008632	catalytic motif [active]
205922008633	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
205922008634	active site clefts [active]
205922008635	zinc binding site [ion binding]; other site
205922008636	dimer interface [polypeptide binding]; other site
205922008637	thiamine pyrophosphate protein; Provisional; Region: PRK08273
205922008638	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
205922008639	PYR/PP interface [polypeptide binding]; other site
205922008640	dimer interface [polypeptide binding]; other site
205922008641	tetramer interface [polypeptide binding]; other site
205922008642	TPP binding site [chemical binding]; other site
205922008643	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
205922008644	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
205922008645	TPP-binding site [chemical binding]; other site
205922008646	Uncharacterized conserved protein [Function unknown]; Region: COG3542
205922008647	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922008648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008649	active site
205922008650	phosphorylation site [posttranslational modification]
205922008651	intermolecular recognition site; other site
205922008652	dimerization interface [polypeptide binding]; other site
205922008653	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922008654	DNA binding site [nucleotide binding]
205922008655	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
205922008656	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
205922008657	homotrimer interaction site [polypeptide binding]; other site
205922008658	putative active site [active]
205922008659	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
205922008660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922008661	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
205922008662	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
205922008663	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922008664	Cytochrome c; Region: Cytochrom_C; cl11414
205922008665	Cytochrome c; Region: Cytochrom_C; cl11414
205922008666	Cytochrome c; Region: Cytochrom_C; cl11414
205922008667	Cytochrome c; Region: Cytochrom_C; cl11414
205922008668	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
205922008669	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922008670	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922008671	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
205922008672	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
205922008673	active site
205922008674	acyl-CoA synthetase; Validated; Region: PRK06188
205922008675	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922008676	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
205922008677	acyl-activating enzyme (AAE) consensus motif; other site
205922008678	acyl-activating enzyme (AAE) consensus motif; other site
205922008679	putative AMP binding site [chemical binding]; other site
205922008680	putative active site [active]
205922008681	putative CoA binding site [chemical binding]; other site
205922008682	Uncharacterized conserved protein [Function unknown]; Region: COG3268
205922008683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922008684	NAD(P) binding site [chemical binding]; other site
205922008685	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922008686	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
205922008687	active site
205922008688	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
205922008689	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
205922008690	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
205922008691	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
205922008692	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922008693	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
205922008694	classical (c) SDRs; Region: SDR_c; cd05233
205922008695	NAD(P) binding site [chemical binding]; other site
205922008696	active site
205922008697	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922008698	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
205922008699	substrate binding site [chemical binding]; other site
205922008700	oxyanion hole (OAH) forming residues; other site
205922008701	trimer interface [polypeptide binding]; other site
205922008702	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922008703	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922008704	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922008705	HTH DNA binding domain; Region: HTH_10; pfam04967
205922008706	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922008707	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
205922008708	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
205922008709	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
205922008710	Protein export membrane protein; Region: SecD_SecF; cl14618
205922008711	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
205922008712	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922008713	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922008714	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
205922008715	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922008716	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922008717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922008718	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922008719	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922008720	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922008721	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
205922008722	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
205922008723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922008724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008725	dimer interface [polypeptide binding]; other site
205922008726	phosphorylation site [posttranslational modification]
205922008727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008728	ATP binding site [chemical binding]; other site
205922008729	Mg2+ binding site [ion binding]; other site
205922008730	G-X-G motif; other site
205922008731	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
205922008732	Helix-turn-helix domain; Region: HTH_38; pfam13936
205922008733	Homeodomain-like domain; Region: HTH_32; pfam13565
205922008734	Integrase core domain; Region: rve; pfam00665
205922008735	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
205922008736	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
205922008737	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
205922008738	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
205922008739	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922008740	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922008741	putative Zn2+ binding site [ion binding]; other site
205922008742	putative DNA binding site [nucleotide binding]; other site
205922008743	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
205922008744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922008745	NAD(P) binding site [chemical binding]; other site
205922008746	active site
205922008747	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922008748	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922008749	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205922008750	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
205922008751	dimerization interface [polypeptide binding]; other site
205922008752	ligand binding site [chemical binding]; other site
205922008753	NADP binding site [chemical binding]; other site
205922008754	catalytic site [active]
205922008755	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
205922008756	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
205922008757	tetramer interface [polypeptide binding]; other site
205922008758	active site
205922008759	Mg2+/Mn2+ binding site [ion binding]; other site
205922008760	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
205922008761	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922008762	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
205922008763	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
205922008764	putative active site pocket [active]
205922008765	metal binding site [ion binding]; metal-binding site
205922008766	cell density-dependent motility repressor; Provisional; Region: PRK10082
205922008767	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008768	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922008769	dimerization interface [polypeptide binding]; other site
205922008770	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
205922008771	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
205922008772	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
205922008773	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
205922008774	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
205922008775	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205922008776	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
205922008777	Walker A/P-loop; other site
205922008778	ATP binding site [chemical binding]; other site
205922008779	Q-loop/lid; other site
205922008780	ABC transporter signature motif; other site
205922008781	Walker B; other site
205922008782	D-loop; other site
205922008783	H-loop/switch region; other site
205922008784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922008785	dimer interface [polypeptide binding]; other site
205922008786	conserved gate region; other site
205922008787	ABC-ATPase subunit interface; other site
205922008788	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922008789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008790	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
205922008791	putative effector binding pocket; other site
205922008792	putative dimerization interface [polypeptide binding]; other site
205922008793	short chain dehydrogenase; Provisional; Region: PRK06197
205922008794	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
205922008795	putative NAD(P) binding site [chemical binding]; other site
205922008796	active site
205922008797	TLC ATP/ADP transporter; Region: TLC; cl03940
205922008798	TLC ATP/ADP transporter; Region: TLC; cl03940
205922008799	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
205922008800	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
205922008801	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
205922008802	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
205922008803	ZIP Zinc transporter; Region: Zip; pfam02535
205922008804	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
205922008805	dimanganese center [ion binding]; other site
205922008806	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
205922008807	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
205922008808	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
205922008809	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
205922008810	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
205922008811	GntP family permease; Region: GntP_permease; pfam02447
205922008812	fructuronate transporter; Provisional; Region: PRK10034; cl15264
205922008813	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
205922008814	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922008815	active site
205922008816	benzoate transport; Region: 2A0115; TIGR00895
205922008817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922008818	putative substrate translocation pore; other site
205922008819	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205922008820	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922008821	DNA-binding site [nucleotide binding]; DNA binding site
205922008822	UTRA domain; Region: UTRA; pfam07702
205922008823	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
205922008824	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
205922008825	active site
205922008826	non-prolyl cis peptide bond; other site
205922008827	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922008828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922008829	dimer interface [polypeptide binding]; other site
205922008830	conserved gate region; other site
205922008831	putative PBP binding loops; other site
205922008832	ABC-ATPase subunit interface; other site
205922008833	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922008834	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922008835	substrate binding pocket [chemical binding]; other site
205922008836	membrane-bound complex binding site; other site
205922008837	hinge residues; other site
205922008838	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
205922008839	transcriptional regulator; Provisional; Region: PRK10632
205922008840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922008841	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922008842	putative effector binding pocket; other site
205922008843	dimerization interface [polypeptide binding]; other site
205922008844	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922008845	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
205922008846	tetramerization interface [polypeptide binding]; other site
205922008847	NAD(P) binding site [chemical binding]; other site
205922008848	catalytic residues [active]
205922008849	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
205922008850	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
205922008851	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
205922008852	NAD(P) binding site [chemical binding]; other site
205922008853	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
205922008854	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
205922008855	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
205922008856	PAS domain S-box; Region: sensory_box; TIGR00229
205922008857	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922008858	putative active site [active]
205922008859	heme pocket [chemical binding]; other site
205922008860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922008861	PAS fold; Region: PAS_3; pfam08447
205922008862	putative active site [active]
205922008863	heme pocket [chemical binding]; other site
205922008864	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922008865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922008866	putative active site [active]
205922008867	heme pocket [chemical binding]; other site
205922008868	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922008869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008870	dimer interface [polypeptide binding]; other site
205922008871	phosphorylation site [posttranslational modification]
205922008872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008873	ATP binding site [chemical binding]; other site
205922008874	Mg2+ binding site [ion binding]; other site
205922008875	G-X-G motif; other site
205922008876	Response regulator receiver domain; Region: Response_reg; pfam00072
205922008877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922008878	active site
205922008879	phosphorylation site [posttranslational modification]
205922008880	intermolecular recognition site; other site
205922008881	dimerization interface [polypeptide binding]; other site
205922008882	TspO/MBR family; Region: TspO_MBR; pfam03073
205922008883	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
205922008884	transcriptional activator RfaH; Region: RfaH; TIGR01955
205922008885	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
205922008886	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
205922008887	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
205922008888	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
205922008889	SLBB domain; Region: SLBB; pfam10531
205922008890	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
205922008891	Chain length determinant protein; Region: Wzz; cl15801
205922008892	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
205922008893	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
205922008894	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922008895	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
205922008896	Bacterial sugar transferase; Region: Bac_transf; pfam02397
205922008897	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
205922008898	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
205922008899	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
205922008900	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
205922008901	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
205922008902	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922008903	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
205922008904	putative ADP-binding pocket [chemical binding]; other site
205922008905	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922008906	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
205922008907	putative ADP-binding pocket [chemical binding]; other site
205922008908	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
205922008909	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922008910	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
205922008911	active site
205922008912	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
205922008913	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
205922008914	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
205922008915	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
205922008916	NAD binding site [chemical binding]; other site
205922008917	homodimer interface [polypeptide binding]; other site
205922008918	active site
205922008919	substrate binding site [chemical binding]; other site
205922008920	Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178
205922008921	calcium binding site [ion binding]; other site
205922008922	active site
205922008923	catalytic residues [active]
205922008924	Acyltransferase family; Region: Acyl_transf_3; pfam01757
205922008925	Helix-turn-helix domain; Region: HTH_18; pfam12833
205922008926	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922008927	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922008928	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922008929	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922008930	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922008931	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922008932	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
205922008933	mce related protein; Region: MCE; pfam02470
205922008934	mce related protein; Region: MCE; pfam02470
205922008935	mce related protein; Region: MCE; pfam02470
205922008936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
205922008937	Protein of unknown function (DUF330); Region: DUF330; pfam03886
205922008938	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922008939	HAMP domain; Region: HAMP; pfam00672
205922008940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922008941	dimer interface [polypeptide binding]; other site
205922008942	phosphorylation site [posttranslational modification]
205922008943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922008944	ATP binding site [chemical binding]; other site
205922008945	Mg2+ binding site [ion binding]; other site
205922008946	G-X-G motif; other site
205922008947	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
205922008948	catalytic core [active]
205922008949	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
205922008950	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
205922008951	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
205922008952	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
205922008953	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205922008954	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205922008955	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
205922008956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922008957	dimer interface [polypeptide binding]; other site
205922008958	conserved gate region; other site
205922008959	ABC-ATPase subunit interface; other site
205922008960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922008961	dimer interface [polypeptide binding]; other site
205922008962	conserved gate region; other site
205922008963	putative PBP binding loops; other site
205922008964	ABC-ATPase subunit interface; other site
205922008965	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922008966	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
205922008967	Walker A/P-loop; other site
205922008968	ATP binding site [chemical binding]; other site
205922008969	Q-loop/lid; other site
205922008970	ABC transporter signature motif; other site
205922008971	Walker B; other site
205922008972	D-loop; other site
205922008973	H-loop/switch region; other site
205922008974	TOBE domain; Region: TOBE_2; pfam08402
205922008975	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
205922008976	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
205922008977	active site
205922008978	DNA binding site [nucleotide binding]
205922008979	Int/Topo IB signature motif; other site
205922008980	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
205922008981	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
205922008982	inhibitor-cofactor binding pocket; inhibition site
205922008983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922008984	catalytic residue [active]
205922008985	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
205922008986	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
205922008987	Ligand binding site; other site
205922008988	Putative Catalytic site; other site
205922008989	DXD motif; other site
205922008990	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
205922008991	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
205922008992	active site
205922008993	substrate binding site [chemical binding]; other site
205922008994	cosubstrate binding site; other site
205922008995	catalytic site [active]
205922008996	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
205922008997	active site
205922008998	hexamer interface [polypeptide binding]; other site
205922008999	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
205922009000	NAD binding site [chemical binding]; other site
205922009001	substrate binding site [chemical binding]; other site
205922009002	active site
205922009003	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
205922009004	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
205922009005	putative active site [active]
205922009006	putative catalytic site [active]
205922009007	putative Zn binding site [ion binding]; other site
205922009008	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
205922009009	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
205922009010	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
205922009011	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
205922009012	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
205922009013	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
205922009014	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
205922009015	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
205922009016	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
205922009017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922009018	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205922009019	Coenzyme A binding pocket [chemical binding]; other site
205922009020	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922009021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922009022	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922009023	dimerization interface [polypeptide binding]; other site
205922009024	argininosuccinate lyase; Provisional; Region: PRK00855
205922009025	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
205922009026	active sites [active]
205922009027	tetramer interface [polypeptide binding]; other site
205922009028	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922009029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009030	dimer interface [polypeptide binding]; other site
205922009031	conserved gate region; other site
205922009032	putative PBP binding loops; other site
205922009033	ABC-ATPase subunit interface; other site
205922009034	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922009035	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922009036	Walker A/P-loop; other site
205922009037	ATP binding site [chemical binding]; other site
205922009038	Q-loop/lid; other site
205922009039	ABC transporter signature motif; other site
205922009040	Walker B; other site
205922009041	D-loop; other site
205922009042	H-loop/switch region; other site
205922009043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922009044	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922009045	substrate binding pocket [chemical binding]; other site
205922009046	membrane-bound complex binding site; other site
205922009047	hinge residues; other site
205922009048	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
205922009049	active site
205922009050	catalytic site [active]
205922009051	Zn binding site [ion binding]; other site
205922009052	tetramer interface [polypeptide binding]; other site
205922009053	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
205922009054	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
205922009055	active site
205922009056	catalytic site [active]
205922009057	Zn binding site [ion binding]; other site
205922009058	tetramer interface [polypeptide binding]; other site
205922009059	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
205922009060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922009061	putative substrate translocation pore; other site
205922009062	HPP family; Region: HPP; pfam04982
205922009063	acyl-coenzyme A oxidase; Region: PLN02636
205922009064	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922009065	active site
205922009066	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
205922009067	Cytochrome P450; Region: p450; cl12078
205922009068	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
205922009069	homotrimer interaction site [polypeptide binding]; other site
205922009070	putative active site [active]
205922009071	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
205922009072	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
205922009073	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
205922009074	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922009075	substrate binding site [chemical binding]; other site
205922009076	oxyanion hole (OAH) forming residues; other site
205922009077	trimer interface [polypeptide binding]; other site
205922009078	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
205922009079	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922009080	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922009081	active site
205922009082	enoyl-CoA hydratase; Provisional; Region: PRK05862
205922009083	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922009084	substrate binding site [chemical binding]; other site
205922009085	oxyanion hole (OAH) forming residues; other site
205922009086	trimer interface [polypeptide binding]; other site
205922009087	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922009088	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922009089	active site
205922009090	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
205922009091	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922009092	dimer interface [polypeptide binding]; other site
205922009093	active site
205922009094	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
205922009095	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922009096	NAD(P) binding site [chemical binding]; other site
205922009097	active site
205922009098	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
205922009099	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922009100	acyl-activating enzyme (AAE) consensus motif; other site
205922009101	AMP binding site [chemical binding]; other site
205922009102	active site
205922009103	CoA binding site [chemical binding]; other site
205922009104	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922009105	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922009106	SurA N-terminal domain; Region: SurA_N; pfam09312
205922009107	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922009108	Iron permease FTR1 family; Region: FTR1; cl00475
205922009109	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
205922009110	Imelysin; Region: Peptidase_M75; pfam09375
205922009111	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
205922009112	Imelysin; Region: Peptidase_M75; pfam09375
205922009113	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
205922009114	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
205922009115	domain interface [polypeptide binding]; other site
205922009116	putative active site [active]
205922009117	catalytic site [active]
205922009118	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
205922009119	domain interface [polypeptide binding]; other site
205922009120	putative active site [active]
205922009121	catalytic site [active]
205922009122	putative transcriptional regulator; Provisional; Region: PRK11640
205922009123	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922009124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
205922009125	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
205922009126	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
205922009127	active site
205922009128	dimer interface [polypeptide binding]; other site
205922009129	non-prolyl cis peptide bond; other site
205922009130	insertion regions; other site
205922009131	hypothetical protein; Provisional; Region: PRK10621
205922009132	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922009133	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
205922009134	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
205922009135	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
205922009136	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
205922009137	putative NADH binding site [chemical binding]; other site
205922009138	putative active site [active]
205922009139	nudix motif; other site
205922009140	putative metal binding site [ion binding]; other site
205922009141	enoyl-CoA hydratase; Provisional; Region: PRK06142
205922009142	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922009143	substrate binding site [chemical binding]; other site
205922009144	oxyanion hole (OAH) forming residues; other site
205922009145	trimer interface [polypeptide binding]; other site
205922009146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922009147	S-adenosylmethionine binding site [chemical binding]; other site
205922009148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922009149	TPR motif; other site
205922009150	Tetratricopeptide repeat; Region: TPR_16; pfam13432
205922009151	binding surface
205922009152	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
205922009153	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922009154	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922009155	DNA binding residues [nucleotide binding]
205922009156	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
205922009157	Isochorismatase family; Region: Isochorismatase; pfam00857
205922009158	catalytic triad [active]
205922009159	metal binding site [ion binding]; metal-binding site
205922009160	conserved cis-peptide bond; other site
205922009161	putative acetyltransferase YhhY; Provisional; Region: PRK10140
205922009162	sensor protein RstB; Provisional; Region: PRK10604
205922009163	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
205922009164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922009165	dimer interface [polypeptide binding]; other site
205922009166	phosphorylation site [posttranslational modification]
205922009167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009168	ATP binding site [chemical binding]; other site
205922009169	Mg2+ binding site [ion binding]; other site
205922009170	G-X-G motif; other site
205922009171	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922009172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009173	active site
205922009174	phosphorylation site [posttranslational modification]
205922009175	intermolecular recognition site; other site
205922009176	dimerization interface [polypeptide binding]; other site
205922009177	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922009178	DNA binding site [nucleotide binding]
205922009179	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
205922009180	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922009181	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922009182	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
205922009183	Protein export membrane protein; Region: SecD_SecF; cl14618
205922009184	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
205922009185	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
205922009186	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
205922009187	Autotransporter beta-domain; Region: Autotransporter; pfam03797
205922009188	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205922009189	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205922009190	DNA binding site [nucleotide binding]
205922009191	domain linker motif; other site
205922009192	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
205922009193	putative dimerization interface [polypeptide binding]; other site
205922009194	putative ligand binding site [chemical binding]; other site
205922009195	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
205922009196	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205922009197	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
205922009198	substrate binding site [chemical binding]; other site
205922009199	ATP binding site [chemical binding]; other site
205922009200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922009201	D-galactonate transporter; Region: 2A0114; TIGR00893
205922009202	putative substrate translocation pore; other site
205922009203	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
205922009204	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
205922009205	dimerization interface [polypeptide binding]; other site
205922009206	ligand binding site [chemical binding]; other site
205922009207	NADP binding site [chemical binding]; other site
205922009208	catalytic site [active]
205922009209	aspartate aminotransferase; Provisional; Region: PRK05764
205922009210	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922009211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922009212	homodimer interface [polypeptide binding]; other site
205922009213	catalytic residue [active]
205922009214	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922009215	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922009216	dimerization interface [polypeptide binding]; other site
205922009217	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922009218	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922009219	dimer interface [polypeptide binding]; other site
205922009220	putative CheW interface [polypeptide binding]; other site
205922009221	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
205922009222	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
205922009223	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
205922009224	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
205922009225	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
205922009226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922009227	putative substrate translocation pore; other site
205922009228	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
205922009229	active site
205922009230	metal binding site [ion binding]; metal-binding site
205922009231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922009232	NAD(P) binding site [chemical binding]; other site
205922009233	active site
205922009234	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922009235	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922009236	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922009237	putative effector binding pocket; other site
205922009238	dimerization interface [polypeptide binding]; other site
205922009239	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922009240	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922009241	active site
205922009242	catalytic tetrad [active]
205922009243	Predicted permeases [General function prediction only]; Region: RarD; COG2962
205922009244	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
205922009245	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
205922009246	dimer interface [polypeptide binding]; other site
205922009247	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
205922009248	active site
205922009249	Fe binding site [ion binding]; other site
205922009250	EamA-like transporter family; Region: EamA; pfam00892
205922009251	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
205922009252	EamA-like transporter family; Region: EamA; pfam00892
205922009253	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922009254	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922009255	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922009256	dimerization interface [polypeptide binding]; other site
205922009257	phage resistance protein; Provisional; Region: PRK10551
205922009258	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
205922009259	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922009260	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
205922009261	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922009262	dimer interface [polypeptide binding]; other site
205922009263	active site
205922009264	metal binding site [ion binding]; metal-binding site
205922009265	glutathione binding site [chemical binding]; other site
205922009266	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
205922009267	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
205922009268	catalytic residue [active]
205922009269	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
205922009270	catalytic residues [active]
205922009271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922009272	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922009273	peroxiredoxin; Region: AhpC; TIGR03137
205922009274	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
205922009275	dimer interface [polypeptide binding]; other site
205922009276	decamer (pentamer of dimers) interface [polypeptide binding]; other site
205922009277	catalytic triad [active]
205922009278	peroxidatic and resolving cysteines [active]
205922009279	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
205922009280	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
205922009281	DNA binding site [nucleotide binding]
205922009282	dimer interface [polypeptide binding]; other site
205922009283	active site
205922009284	Int/Topo IB signature motif; other site
205922009285	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
205922009286	glutathione reductase; Validated; Region: PRK06116
205922009287	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922009288	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922009289	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205922009290	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
205922009291	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
205922009292	active site
205922009293	tetramer interface; other site
205922009294	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
205922009295	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
205922009296	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
205922009297	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
205922009298	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
205922009299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922009300	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
205922009301	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
205922009302	DNA binding site [nucleotide binding]
205922009303	active site
205922009304	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
205922009305	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
205922009306	NADP binding site [chemical binding]; other site
205922009307	dimer interface [polypeptide binding]; other site
205922009308	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
205922009309	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
205922009310	FMN binding site [chemical binding]; other site
205922009311	substrate binding site [chemical binding]; other site
205922009312	putative catalytic residue [active]
205922009313	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205922009314	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922009315	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
205922009316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009317	dimer interface [polypeptide binding]; other site
205922009318	conserved gate region; other site
205922009319	putative PBP binding loops; other site
205922009320	ABC-ATPase subunit interface; other site
205922009321	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
205922009322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922009323	Walker A/P-loop; other site
205922009324	ATP binding site [chemical binding]; other site
205922009325	Q-loop/lid; other site
205922009326	ABC transporter signature motif; other site
205922009327	Walker B; other site
205922009328	D-loop; other site
205922009329	H-loop/switch region; other site
205922009330	TOBE domain; Region: TOBE; cl01440
205922009331	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
205922009332	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
205922009333	active site
205922009334	DNA binding site [nucleotide binding]
205922009335	Int/Topo IB signature motif; other site
205922009336	catalytic residues [active]
205922009337	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
205922009338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922009339	Walker A/P-loop; other site
205922009340	ATP binding site [chemical binding]; other site
205922009341	Q-loop/lid; other site
205922009342	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922009343	ABC transporter signature motif; other site
205922009344	Walker B; other site
205922009345	D-loop; other site
205922009346	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922009347	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
205922009348	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
205922009349	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
205922009350	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
205922009351	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922009352	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922009353	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
205922009354	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
205922009355	active site
205922009356	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
205922009357	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
205922009358	heme exporter protein CcmC; Region: ccmC; TIGR01191
205922009359	Benzoate membrane transport protein; Region: BenE; pfam03594
205922009360	benzoate transporter; Region: benE; TIGR00843
205922009361	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
205922009362	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
205922009363	dimer interface [polypeptide binding]; other site
205922009364	active site
205922009365	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
205922009366	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
205922009367	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
205922009368	octamer interface [polypeptide binding]; other site
205922009369	active site
205922009370	benzoate transport; Region: 2A0115; TIGR00895
205922009371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922009372	putative substrate translocation pore; other site
205922009373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922009374	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
205922009375	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
205922009376	putative NAD(P) binding site [chemical binding]; other site
205922009377	active site
205922009378	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
205922009379	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922009380	catalytic loop [active]
205922009381	iron binding site [ion binding]; other site
205922009382	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
205922009383	FAD binding pocket [chemical binding]; other site
205922009384	FAD binding motif [chemical binding]; other site
205922009385	phosphate binding motif [ion binding]; other site
205922009386	beta-alpha-beta structure motif; other site
205922009387	NAD binding pocket [chemical binding]; other site
205922009388	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
205922009389	inter-subunit interface; other site
205922009390	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
205922009391	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
205922009392	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
205922009393	putative alpha subunit interface [polypeptide binding]; other site
205922009394	putative active site [active]
205922009395	putative substrate binding site [chemical binding]; other site
205922009396	Fe binding site [ion binding]; other site
205922009397	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922009398	Helix-turn-helix domain; Region: HTH_18; pfam12833
205922009399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922009400	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922009401	dimerization interface [polypeptide binding]; other site
205922009402	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922009403	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922009404	dimer interface [polypeptide binding]; other site
205922009405	putative CheW interface [polypeptide binding]; other site
205922009406	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
205922009407	active site
205922009408	catalytic residues [active]
205922009409	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
205922009410	Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992
205922009411	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
205922009412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922009413	FeS/SAM binding site; other site
205922009414	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
205922009415	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
205922009416	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922009417	Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098
205922009418	Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099
205922009419	Domain of unknown function (DUF1928); Region: DUF1928; pfam09100
205922009420	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
205922009421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922009422	Walker A motif; other site
205922009423	ATP binding site [chemical binding]; other site
205922009424	Walker B motif; other site
205922009425	arginine finger; other site
205922009426	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922009427	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922009428	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
205922009429	NAD(P) binding site [chemical binding]; other site
205922009430	catalytic residues [active]
205922009431	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
205922009432	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
205922009433	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205922009434	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922009435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922009436	Walker A/P-loop; other site
205922009437	ATP binding site [chemical binding]; other site
205922009438	Q-loop/lid; other site
205922009439	ABC transporter signature motif; other site
205922009440	Walker B; other site
205922009441	D-loop; other site
205922009442	H-loop/switch region; other site
205922009443	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
205922009444	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922009445	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
205922009446	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922009447	Bacterial transcriptional regulator; Region: IclR; pfam01614
205922009448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922009449	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922009450	putative substrate translocation pore; other site
205922009451	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205922009452	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
205922009453	ligand binding site [chemical binding]; other site
205922009454	NAD binding site [chemical binding]; other site
205922009455	dimerization interface [polypeptide binding]; other site
205922009456	catalytic site [active]
205922009457	hypothetical protein; Validated; Region: PRK06201
205922009458	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
205922009459	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922009460	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922009461	conserved cys residue [active]
205922009462	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922009463	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
205922009464	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
205922009465	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
205922009466	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922009467	Magnesium ion binding site [ion binding]; other site
205922009468	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
205922009469	ParB-like nuclease domain; Region: ParBc; pfam02195
205922009470	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
205922009471	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
205922009472	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
205922009473	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
205922009474	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
205922009475	dimer interface [polypeptide binding]; other site
205922009476	ssDNA binding site [nucleotide binding]; other site
205922009477	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205922009478	DNA topoisomerase III; Provisional; Region: PRK07726
205922009479	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
205922009480	active site
205922009481	putative interdomain interaction site [polypeptide binding]; other site
205922009482	putative metal-binding site [ion binding]; other site
205922009483	putative nucleotide binding site [chemical binding]; other site
205922009484	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
205922009485	domain I; other site
205922009486	DNA binding groove [nucleotide binding]
205922009487	phosphate binding site [ion binding]; other site
205922009488	domain II; other site
205922009489	domain III; other site
205922009490	nucleotide binding site [chemical binding]; other site
205922009491	catalytic site [active]
205922009492	domain IV; other site
205922009493	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
205922009494	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
205922009495	hypothetical protein; Reviewed; Region: PRK00024
205922009496	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
205922009497	MPN+ (JAMM) motif; other site
205922009498	Zinc-binding site [ion binding]; other site
205922009499	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
205922009500	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
205922009501	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
205922009502	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
205922009503	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
205922009504	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
205922009505	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
205922009506	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
205922009507	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
205922009508	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
205922009509	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
205922009510	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
205922009511	integrating conjugative element protein, PFL_4704 family; Region: conj_TIGR03749
205922009512	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
205922009513	Protein of unknown function (DUF904); Region: DUF904; pfam06005
205922009514	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
205922009515	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
205922009516	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
205922009517	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
205922009518	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922009519	non-specific DNA binding site [nucleotide binding]; other site
205922009520	salt bridge; other site
205922009521	sequence-specific DNA binding site [nucleotide binding]; other site
205922009522	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
205922009523	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
205922009524	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
205922009525	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
205922009526	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
205922009527	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
205922009528	Putative helicase; Region: TraI_2; pfam07514
205922009529	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
205922009530	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
205922009531	Low affinity iron permease; Region: Iron_permease; cl12096
205922009532	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
205922009533	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205922009534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922009535	dimer interface [polypeptide binding]; other site
205922009536	phosphorylation site [posttranslational modification]
205922009537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009538	ATP binding site [chemical binding]; other site
205922009539	Mg2+ binding site [ion binding]; other site
205922009540	G-X-G motif; other site
205922009541	Response regulator receiver domain; Region: Response_reg; pfam00072
205922009542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009543	active site
205922009544	phosphorylation site [posttranslational modification]
205922009545	intermolecular recognition site; other site
205922009546	dimerization interface [polypeptide binding]; other site
205922009547	Response regulator receiver domain; Region: Response_reg; pfam00072
205922009548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009549	active site
205922009550	phosphorylation site [posttranslational modification]
205922009551	intermolecular recognition site; other site
205922009552	dimerization interface [polypeptide binding]; other site
205922009553	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922009554	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205922009555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922009556	dimer interface [polypeptide binding]; other site
205922009557	phosphorylation site [posttranslational modification]
205922009558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009559	ATP binding site [chemical binding]; other site
205922009560	Mg2+ binding site [ion binding]; other site
205922009561	G-X-G motif; other site
205922009562	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922009563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009564	active site
205922009565	phosphorylation site [posttranslational modification]
205922009566	intermolecular recognition site; other site
205922009567	dimerization interface [polypeptide binding]; other site
205922009568	transcriptional regulator RcsB; Provisional; Region: PRK10840
205922009569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009570	active site
205922009571	phosphorylation site [posttranslational modification]
205922009572	intermolecular recognition site; other site
205922009573	dimerization interface [polypeptide binding]; other site
205922009574	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922009575	DNA binding residues [nucleotide binding]
205922009576	dimerization interface [polypeptide binding]; other site
205922009577	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
205922009578	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
205922009579	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
205922009580	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
205922009581	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
205922009582	PapC N-terminal domain; Region: PapC_N; pfam13954
205922009583	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
205922009584	PapC C-terminal domain; Region: PapC_C; pfam13953
205922009585	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
205922009586	Nucleoid-associated protein [General function prediction only]; Region: COG3081
205922009587	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
205922009588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922009589	S-adenosylmethionine binding site [chemical binding]; other site
205922009590	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922009591	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
205922009592	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
205922009593	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922009594	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922009595	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
205922009596	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
205922009597	Helix-turn-helix domain; Region: HTH_38; pfam13936
205922009598	Homeodomain-like domain; Region: HTH_32; pfam13565
205922009599	Integrase core domain; Region: rve; pfam00665
205922009600	Transposase domain (DUF772); Region: DUF772; pfam05598
205922009601	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
205922009602	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
205922009603	integrase; Provisional; Region: PRK09692
205922009604	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
205922009605	active site
205922009606	Int/Topo IB signature motif; other site
205922009607	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
205922009608	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
205922009609	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
205922009610	GIY-YIG motif/motif A; other site
205922009611	active site
205922009612	catalytic site [active]
205922009613	putative DNA binding site [nucleotide binding]; other site
205922009614	metal binding site [ion binding]; metal-binding site
205922009615	UvrB/uvrC motif; Region: UVR; pfam02151
205922009616	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
205922009617	response regulator; Provisional; Region: PRK09483
205922009618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009619	active site
205922009620	phosphorylation site [posttranslational modification]
205922009621	intermolecular recognition site; other site
205922009622	dimerization interface [polypeptide binding]; other site
205922009623	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922009624	DNA binding residues [nucleotide binding]
205922009625	dimerization interface [polypeptide binding]; other site
205922009626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922009627	Coenzyme A binding pocket [chemical binding]; other site
205922009628	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
205922009629	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
205922009630	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
205922009631	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
205922009632	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205922009633	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
205922009634	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
205922009635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009636	dimer interface [polypeptide binding]; other site
205922009637	conserved gate region; other site
205922009638	putative PBP binding loops; other site
205922009639	ABC-ATPase subunit interface; other site
205922009640	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
205922009641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009642	dimer interface [polypeptide binding]; other site
205922009643	conserved gate region; other site
205922009644	putative PBP binding loops; other site
205922009645	ABC-ATPase subunit interface; other site
205922009646	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
205922009647	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922009648	Walker A/P-loop; other site
205922009649	ATP binding site [chemical binding]; other site
205922009650	Q-loop/lid; other site
205922009651	ABC transporter signature motif; other site
205922009652	Walker B; other site
205922009653	D-loop; other site
205922009654	H-loop/switch region; other site
205922009655	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922009656	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922009657	Walker A/P-loop; other site
205922009658	ATP binding site [chemical binding]; other site
205922009659	Q-loop/lid; other site
205922009660	ABC transporter signature motif; other site
205922009661	Walker B; other site
205922009662	D-loop; other site
205922009663	H-loop/switch region; other site
205922009664	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922009665	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
205922009666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922009667	Walker A motif; other site
205922009668	ATP binding site [chemical binding]; other site
205922009669	Walker B motif; other site
205922009670	arginine finger; other site
205922009671	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922009672	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
205922009673	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
205922009674	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
205922009675	NAD binding site [chemical binding]; other site
205922009676	homotetramer interface [polypeptide binding]; other site
205922009677	homodimer interface [polypeptide binding]; other site
205922009678	substrate binding site [chemical binding]; other site
205922009679	active site
205922009680	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
205922009681	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
205922009682	acyl-activating enzyme (AAE) consensus motif; other site
205922009683	putative AMP binding site [chemical binding]; other site
205922009684	putative active site [active]
205922009685	putative CoA binding site [chemical binding]; other site
205922009686	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
205922009687	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205922009688	Walker A motif; other site
205922009689	ATP binding site [chemical binding]; other site
205922009690	Walker B motif; other site
205922009691	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922009692	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922009693	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922009694	heme pocket [chemical binding]; other site
205922009695	putative active site [active]
205922009696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922009697	putative active site [active]
205922009698	heme pocket [chemical binding]; other site
205922009699	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
205922009700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922009701	dimer interface [polypeptide binding]; other site
205922009702	phosphorylation site [posttranslational modification]
205922009703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009704	ATP binding site [chemical binding]; other site
205922009705	Mg2+ binding site [ion binding]; other site
205922009706	G-X-G motif; other site
205922009707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009708	Response regulator receiver domain; Region: Response_reg; pfam00072
205922009709	active site
205922009710	phosphorylation site [posttranslational modification]
205922009711	intermolecular recognition site; other site
205922009712	dimerization interface [polypeptide binding]; other site
205922009713	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
205922009714	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205922009715	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
205922009716	substrate binding site [chemical binding]; other site
205922009717	ATP binding site [chemical binding]; other site
205922009718	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
205922009719	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
205922009720	dimer interface [polypeptide binding]; other site
205922009721	active site
205922009722	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922009723	substrate binding site [chemical binding]; other site
205922009724	catalytic residue [active]
205922009725	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922009726	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
205922009727	Bacterial transcriptional regulator; Region: IclR; pfam01614
205922009728	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
205922009729	homotrimer interaction site [polypeptide binding]; other site
205922009730	putative active site [active]
205922009731	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922009732	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922009733	Walker A/P-loop; other site
205922009734	ATP binding site [chemical binding]; other site
205922009735	Q-loop/lid; other site
205922009736	ABC transporter signature motif; other site
205922009737	Walker B; other site
205922009738	D-loop; other site
205922009739	H-loop/switch region; other site
205922009740	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922009741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009742	dimer interface [polypeptide binding]; other site
205922009743	conserved gate region; other site
205922009744	putative PBP binding loops; other site
205922009745	ABC-ATPase subunit interface; other site
205922009746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009747	dimer interface [polypeptide binding]; other site
205922009748	conserved gate region; other site
205922009749	putative PBP binding loops; other site
205922009750	ABC-ATPase subunit interface; other site
205922009751	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922009752	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922009753	substrate binding pocket [chemical binding]; other site
205922009754	membrane-bound complex binding site; other site
205922009755	hinge residues; other site
205922009756	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205922009757	catalytic residues [active]
205922009758	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
205922009759	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
205922009760	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
205922009761	Transporter associated domain; Region: CorC_HlyC; smart01091
205922009762	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
205922009763	PLD-like domain; Region: PLDc_2; pfam13091
205922009764	putative active site [active]
205922009765	catalytic site [active]
205922009766	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
205922009767	PLD-like domain; Region: PLDc_2; pfam13091
205922009768	putative active site [active]
205922009769	catalytic site [active]
205922009770	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
205922009771	metal ion-dependent adhesion site (MIDAS); other site
205922009772	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
205922009773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922009774	Walker A motif; other site
205922009775	ATP binding site [chemical binding]; other site
205922009776	Walker B motif; other site
205922009777	arginine finger; other site
205922009778	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
205922009779	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
205922009780	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
205922009781	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
205922009782	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
205922009783	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
205922009784	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
205922009785	Predicted integral membrane protein [Function unknown]; Region: COG5446
205922009786	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
205922009787	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
205922009788	active site
205922009789	SAM binding site [chemical binding]; other site
205922009790	homodimer interface [polypeptide binding]; other site
205922009791	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
205922009792	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
205922009793	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
205922009794	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922009795	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
205922009796	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
205922009797	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
205922009798	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
205922009799	substrate binding pocket [chemical binding]; other site
205922009800	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
205922009801	B12 binding site [chemical binding]; other site
205922009802	cobalt ligand [ion binding]; other site
205922009803	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
205922009804	Leucine rich repeat; Region: LRR_8; pfam13855
205922009805	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
205922009806	Leucine rich repeat; Region: LRR_8; pfam13855
205922009807	Substrate binding site [chemical binding]; other site
205922009808	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
205922009809	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
205922009810	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
205922009811	putative ligand binding site [chemical binding]; other site
205922009812	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
205922009813	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922009814	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
205922009815	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
205922009816	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
205922009817	putative inner membrane peptidase; Provisional; Region: PRK11778
205922009818	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
205922009819	tandem repeat interface [polypeptide binding]; other site
205922009820	oligomer interface [polypeptide binding]; other site
205922009821	active site residues [active]
205922009822	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
205922009823	catalytic core [active]
205922009824	SCP-2 sterol transfer family; Region: SCP2; pfam02036
205922009825	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
205922009826	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922009827	Walker A/P-loop; other site
205922009828	ATP binding site [chemical binding]; other site
205922009829	Q-loop/lid; other site
205922009830	ABC transporter signature motif; other site
205922009831	Walker B; other site
205922009832	D-loop; other site
205922009833	H-loop/switch region; other site
205922009834	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922009835	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922009836	Walker A/P-loop; other site
205922009837	ATP binding site [chemical binding]; other site
205922009838	Q-loop/lid; other site
205922009839	ABC transporter signature motif; other site
205922009840	Walker B; other site
205922009841	D-loop; other site
205922009842	H-loop/switch region; other site
205922009843	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922009844	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
205922009845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009846	dimer interface [polypeptide binding]; other site
205922009847	conserved gate region; other site
205922009848	putative PBP binding loops; other site
205922009849	ABC-ATPase subunit interface; other site
205922009850	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
205922009851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009852	dimer interface [polypeptide binding]; other site
205922009853	conserved gate region; other site
205922009854	putative PBP binding loops; other site
205922009855	ABC-ATPase subunit interface; other site
205922009856	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205922009857	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
205922009858	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
205922009859	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
205922009860	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922009861	N-terminal plug; other site
205922009862	ligand-binding site [chemical binding]; other site
205922009863	RES domain; Region: RES; cl02411
205922009864	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
205922009865	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922009866	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
205922009867	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922009868	N-terminal plug; other site
205922009869	ligand-binding site [chemical binding]; other site
205922009870	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922009871	FecR protein; Region: FecR; pfam04773
205922009872	RNA polymerase sigma factor; Provisional; Region: PRK12525
205922009873	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922009874	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922009875	DNA binding residues [nucleotide binding]
205922009876	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
205922009877	putative active site [active]
205922009878	putative substrate binding site [chemical binding]; other site
205922009879	putative cosubstrate binding site; other site
205922009880	catalytic site [active]
205922009881	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
205922009882	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
205922009883	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922009884	substrate binding site [chemical binding]; other site
205922009885	oxyanion hole (OAH) forming residues; other site
205922009886	trimer interface [polypeptide binding]; other site
205922009887	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922009888	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922009889	LysR substrate binding domain; Region: LysR_substrate; pfam03466
205922009890	dimerization interface [polypeptide binding]; other site
205922009891	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
205922009892	hydrophobic ligand binding site; other site
205922009893	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
205922009894	Strictosidine synthase; Region: Str_synth; pfam03088
205922009895	Protein of unknown function (DUF465); Region: DUF465; cl01070
205922009896	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
205922009897	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
205922009898	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
205922009899	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
205922009900	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
205922009901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
205922009902	ATP binding site [chemical binding]; other site
205922009903	Mg2+ binding site [ion binding]; other site
205922009904	G-X-G motif; other site
205922009905	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
205922009906	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
205922009907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922009908	dimer interface [polypeptide binding]; other site
205922009909	phosphorylation site [posttranslational modification]
205922009910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009911	ATP binding site [chemical binding]; other site
205922009912	Mg2+ binding site [ion binding]; other site
205922009913	G-X-G motif; other site
205922009914	Response regulator receiver domain; Region: Response_reg; pfam00072
205922009915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009916	active site
205922009917	phosphorylation site [posttranslational modification]
205922009918	intermolecular recognition site; other site
205922009919	dimerization interface [polypeptide binding]; other site
205922009920	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
205922009921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
205922009922	dimer interface [polypeptide binding]; other site
205922009923	phosphorylation site [posttranslational modification]
205922009924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009925	ATP binding site [chemical binding]; other site
205922009926	Mg2+ binding site [ion binding]; other site
205922009927	G-X-G motif; other site
205922009928	Response regulator receiver domain; Region: Response_reg; pfam00072
205922009929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009930	active site
205922009931	phosphorylation site [posttranslational modification]
205922009932	intermolecular recognition site; other site
205922009933	dimerization interface [polypeptide binding]; other site
205922009934	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
205922009935	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
205922009936	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
205922009937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922009938	Walker A/P-loop; other site
205922009939	ATP binding site [chemical binding]; other site
205922009940	Q-loop/lid; other site
205922009941	ABC transporter signature motif; other site
205922009942	Walker B; other site
205922009943	D-loop; other site
205922009944	H-loop/switch region; other site
205922009945	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922009946	PAS fold; Region: PAS_3; pfam08447
205922009947	putative active site [active]
205922009948	heme pocket [chemical binding]; other site
205922009949	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922009950	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922009951	dimer interface [polypeptide binding]; other site
205922009952	phosphorylation site [posttranslational modification]
205922009953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922009954	ATP binding site [chemical binding]; other site
205922009955	Mg2+ binding site [ion binding]; other site
205922009956	G-X-G motif; other site
205922009957	Response regulator receiver domain; Region: Response_reg; pfam00072
205922009958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922009959	active site
205922009960	phosphorylation site [posttranslational modification]
205922009961	intermolecular recognition site; other site
205922009962	dimerization interface [polypeptide binding]; other site
205922009963	Transcriptional regulators [Transcription]; Region: GntR; COG1802
205922009964	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922009965	DNA-binding site [nucleotide binding]; DNA binding site
205922009966	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
205922009967	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922009968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922009969	Walker A/P-loop; other site
205922009970	ATP binding site [chemical binding]; other site
205922009971	Q-loop/lid; other site
205922009972	ABC transporter signature motif; other site
205922009973	Walker B; other site
205922009974	D-loop; other site
205922009975	H-loop/switch region; other site
205922009976	TOBE domain; Region: TOBE_2; pfam08402
205922009977	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
205922009978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009979	dimer interface [polypeptide binding]; other site
205922009980	conserved gate region; other site
205922009981	putative PBP binding loops; other site
205922009982	ABC-ATPase subunit interface; other site
205922009983	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922009984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922009985	dimer interface [polypeptide binding]; other site
205922009986	conserved gate region; other site
205922009987	putative PBP binding loops; other site
205922009988	ABC-ATPase subunit interface; other site
205922009989	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
205922009990	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205922009991	cytosine deaminase; Provisional; Region: PRK05985
205922009992	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
205922009993	active site
205922009994	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151
205922009995	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922009996	active site
205922009997	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
205922009998	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
205922009999	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
205922010000	putative active site [active]
205922010001	putative PHP Thumb interface [polypeptide binding]; other site
205922010002	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
205922010003	generic binding surface I; other site
205922010004	generic binding surface II; other site
205922010005	DNA Polymerase Y-family; Region: PolY_like; cd03468
205922010006	active site
205922010007	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
205922010008	DNA binding site [nucleotide binding]
205922010009	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
205922010010	Uncharacterized conserved protein [Function unknown]; Region: COG4544
205922010011	LexA repressor; Provisional; Region: PRK12423
205922010012	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
205922010013	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
205922010014	Catalytic site [active]
205922010015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922010016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010017	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922010018	putative effector binding pocket; other site
205922010019	dimerization interface [polypeptide binding]; other site
205922010020	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
205922010021	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
205922010022	active site
205922010023	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922010024	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
205922010025	putative metal dependent hydrolase; Provisional; Region: PRK11598
205922010026	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
205922010027	Sulfatase; Region: Sulfatase; pfam00884
205922010028	Protein of unknown function (DUF971); Region: DUF971; pfam06155
205922010029	HEAT repeats; Region: HEAT_2; pfam13646
205922010030	HEAT repeats; Region: HEAT_2; pfam13646
205922010031	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
205922010032	protein binding surface [polypeptide binding]; other site
205922010033	HEAT repeats; Region: HEAT_2; pfam13646
205922010034	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
205922010035	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922010036	Walker A/P-loop; other site
205922010037	ATP binding site [chemical binding]; other site
205922010038	Q-loop/lid; other site
205922010039	ABC transporter signature motif; other site
205922010040	Walker B; other site
205922010041	D-loop; other site
205922010042	H-loop/switch region; other site
205922010043	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922010044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922010045	dimer interface [polypeptide binding]; other site
205922010046	conserved gate region; other site
205922010047	putative PBP binding loops; other site
205922010048	ABC-ATPase subunit interface; other site
205922010049	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
205922010050	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922010051	substrate binding pocket [chemical binding]; other site
205922010052	membrane-bound complex binding site; other site
205922010053	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
205922010054	putative oxidoreductase; Provisional; Region: PRK08275
205922010055	L-aspartate oxidase; Provisional; Region: PRK06175
205922010056	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
205922010057	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205922010058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922010059	DNA-binding site [nucleotide binding]; DNA binding site
205922010060	UTRA domain; Region: UTRA; pfam07702
205922010061	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
205922010062	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
205922010063	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
205922010064	Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413
205922010065	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922010066	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922010067	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922010068	Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313
205922010069	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
205922010070	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
205922010071	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
205922010072	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
205922010073	type II secretion system protein F; Region: GspF; TIGR02120
205922010074	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922010075	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922010076	type II secretion system protein E; Region: type_II_gspE; TIGR02533
205922010077	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
205922010078	Walker A motif; other site
205922010079	ATP binding site [chemical binding]; other site
205922010080	Walker B motif; other site
205922010081	type II secretion system protein D; Region: type_II_gspD; TIGR02517
205922010082	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
205922010083	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
205922010084	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
205922010085	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
205922010086	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
205922010087	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
205922010088	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
205922010089	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
205922010090	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
205922010091	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
205922010092	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
205922010093	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
205922010094	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922010095	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922010096	Coenzyme A binding pocket [chemical binding]; other site
205922010097	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
205922010098	amidase catalytic site [active]
205922010099	Zn binding residues [ion binding]; other site
205922010100	substrate binding site [chemical binding]; other site
205922010101	PAAR motif; Region: PAAR_motif; pfam05488
205922010102	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
205922010103	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922010104	P-loop; other site
205922010105	Magnesium ion binding site [ion binding]; other site
205922010106	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922010107	Magnesium ion binding site [ion binding]; other site
205922010108	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
205922010109	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
205922010110	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
205922010111	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
205922010112	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
205922010113	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
205922010114	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922010115	FecR protein; Region: FecR; pfam04773
205922010116	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
205922010117	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922010118	Gram-negative bacterial tonB protein; Region: TonB; cl10048
205922010119	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
205922010120	Uncharacterized conserved protein [Function unknown]; Region: COG2128
205922010121	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922010122	DNA-binding site [nucleotide binding]; DNA binding site
205922010123	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922010124	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922010125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922010126	homodimer interface [polypeptide binding]; other site
205922010127	catalytic residue [active]
205922010128	Uncharacterized conserved protein [Function unknown]; Region: COG1359
205922010129	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
205922010130	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
205922010131	MoxR-like ATPases [General function prediction only]; Region: COG0714
205922010132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922010133	Walker A motif; other site
205922010134	ATP binding site [chemical binding]; other site
205922010135	Walker B motif; other site
205922010136	arginine finger; other site
205922010137	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
205922010138	Protein of unknown function DUF58; Region: DUF58; pfam01882
205922010139	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
205922010140	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
205922010141	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
205922010142	metal ion-dependent adhesion site (MIDAS); other site
205922010143	von Willebrand factor type A domain; Region: VWA_2; pfam13519
205922010144	metal ion-dependent adhesion site (MIDAS); other site
205922010145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922010146	Tetratricopeptide repeat; Region: TPR_16; pfam13432
205922010147	TPR motif; other site
205922010148	binding surface
205922010149	Oxygen tolerance; Region: BatD; pfam13584
205922010150	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
205922010151	exonuclease subunit SbcD; Provisional; Region: PRK10966
205922010152	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
205922010153	active site
205922010154	metal binding site [ion binding]; metal-binding site
205922010155	DNA binding site [nucleotide binding]
205922010156	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
205922010157	exonuclease SbcC; Region: sbcc; TIGR00618
205922010158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922010159	Walker A/P-loop; other site
205922010160	ATP binding site [chemical binding]; other site
205922010161	Q-loop/lid; other site
205922010162	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922010163	ABC transporter signature motif; other site
205922010164	Walker B; other site
205922010165	D-loop; other site
205922010166	H-loop/switch region; other site
205922010167	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922010168	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
205922010169	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
205922010170	putative N-terminal domain interface [polypeptide binding]; other site
205922010171	putative dimer interface [polypeptide binding]; other site
205922010172	putative substrate binding pocket (H-site) [chemical binding]; other site
205922010173	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
205922010174	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
205922010175	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
205922010176	dimer interface [polypeptide binding]; other site
205922010177	NADP binding site [chemical binding]; other site
205922010178	catalytic residues [active]
205922010179	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
205922010180	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
205922010181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010182	putative substrate translocation pore; other site
205922010183	dihydroxy-acid dehydratase; Validated; Region: PRK06131
205922010184	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922010185	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922010186	DNA-binding site [nucleotide binding]; DNA binding site
205922010187	FCD domain; Region: FCD; pfam07729
205922010188	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
205922010189	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
205922010190	Amino acid synthesis; Region: AA_synth; pfam06684
205922010191	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
205922010192	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
205922010193	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922010194	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
205922010195	NAD(P) binding site [chemical binding]; other site
205922010196	catalytic residues [active]
205922010197	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
205922010198	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
205922010199	Transcriptional regulators [Transcription]; Region: GntR; COG1802
205922010200	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922010201	DNA-binding site [nucleotide binding]; DNA binding site
205922010202	FCD domain; Region: FCD; pfam07729
205922010203	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
205922010204	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
205922010205	nudix motif; other site
205922010206	Uncharacterized conserved protein [Function unknown]; Region: COG5470
205922010207	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485
205922010208	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
205922010209	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
205922010210	dimerization interface [polypeptide binding]; other site
205922010211	active site
205922010212	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
205922010213	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
205922010214	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
205922010215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922010216	dimer interface [polypeptide binding]; other site
205922010217	conserved gate region; other site
205922010218	putative PBP binding loops; other site
205922010219	ABC-ATPase subunit interface; other site
205922010220	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922010221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922010222	dimer interface [polypeptide binding]; other site
205922010223	conserved gate region; other site
205922010224	putative PBP binding loops; other site
205922010225	ABC-ATPase subunit interface; other site
205922010226	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922010227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922010228	Walker A/P-loop; other site
205922010229	ATP binding site [chemical binding]; other site
205922010230	Q-loop/lid; other site
205922010231	ABC transporter signature motif; other site
205922010232	Walker B; other site
205922010233	D-loop; other site
205922010234	H-loop/switch region; other site
205922010235	TOBE domain; Region: TOBE_2; pfam08402
205922010236	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
205922010237	active site
205922010238	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
205922010239	exopolyphosphatase; Region: exo_poly_only; TIGR03706
205922010240	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
205922010241	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
205922010242	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
205922010243	dimer interface [polypeptide binding]; other site
205922010244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922010245	catalytic residue [active]
205922010246	FOG: CBS domain [General function prediction only]; Region: COG0517
205922010247	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
205922010248	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
205922010249	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
205922010250	homodimer interface [polypeptide binding]; other site
205922010251	substrate-cofactor binding pocket; other site
205922010252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922010253	catalytic residue [active]
205922010254	YecR-like lipoprotein; Region: YecR; pfam13992
205922010255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922010256	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
205922010257	dimer interface [polypeptide binding]; other site
205922010258	phosphorylation site [posttranslational modification]
205922010259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922010260	ATP binding site [chemical binding]; other site
205922010261	Mg2+ binding site [ion binding]; other site
205922010262	G-X-G motif; other site
205922010263	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922010264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010265	active site
205922010266	phosphorylation site [posttranslational modification]
205922010267	intermolecular recognition site; other site
205922010268	dimerization interface [polypeptide binding]; other site
205922010269	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922010270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010271	active site
205922010272	phosphorylation site [posttranslational modification]
205922010273	intermolecular recognition site; other site
205922010274	dimerization interface [polypeptide binding]; other site
205922010275	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922010276	DNA binding residues [nucleotide binding]
205922010277	dimerization interface [polypeptide binding]; other site
205922010278	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
205922010279	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
205922010280	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922010281	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922010282	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922010283	amidase; Validated; Region: PRK06565
205922010284	Amidase; Region: Amidase; cl11426
205922010285	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
205922010286	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
205922010287	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922010288	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922010289	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
205922010290	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922010291	Na binding site [ion binding]; other site
205922010292	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
205922010293	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
205922010294	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
205922010295	Predicted transcriptional regulators [Transcription]; Region: COG1733
205922010296	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
205922010297	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922010298	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922010299	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922010300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922010301	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
205922010302	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
205922010303	homotrimer interaction site [polypeptide binding]; other site
205922010304	putative active site [active]
205922010305	Uncharacterized conserved protein [Function unknown]; Region: COG3342
205922010306	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
205922010307	acetylornithine deacetylase; Provisional; Region: PRK07522
205922010308	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
205922010309	metal binding site [ion binding]; metal-binding site
205922010310	putative dimer interface [polypeptide binding]; other site
205922010311	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
205922010312	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922010313	Na binding site [ion binding]; other site
205922010314	Predicted transcriptional regulators [Transcription]; Region: COG1733
205922010315	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922010316	dimerization interface [polypeptide binding]; other site
205922010317	putative DNA binding site [nucleotide binding]; other site
205922010318	putative Zn2+ binding site [ion binding]; other site
205922010319	Isochorismatase family; Region: Isochorismatase; pfam00857
205922010320	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
205922010321	catalytic triad [active]
205922010322	conserved cis-peptide bond; other site
205922010323	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
205922010324	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
205922010325	dimer interface [polypeptide binding]; other site
205922010326	NADP binding site [chemical binding]; other site
205922010327	catalytic residues [active]
205922010328	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
205922010329	active site
205922010330	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922010331	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010332	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
205922010333	putative dimerization interface [polypeptide binding]; other site
205922010334	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
205922010335	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
205922010336	NAD(P) binding site [chemical binding]; other site
205922010337	catalytic residues [active]
205922010338	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922010339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010340	short chain dehydrogenase; Provisional; Region: PRK06180
205922010341	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
205922010342	NADP binding site [chemical binding]; other site
205922010343	active site
205922010344	steroid binding site; other site
205922010345	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922010346	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010347	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
205922010348	putative effector binding pocket; other site
205922010349	putative dimerization interface [polypeptide binding]; other site
205922010350	Predicted membrane protein [Function unknown]; Region: COG3503
205922010351	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
205922010352	FAD binding domain; Region: FAD_binding_4; pfam01565
205922010353	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
205922010354	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922010355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010356	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922010357	dimerization interface [polypeptide binding]; other site
205922010358	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
205922010359	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
205922010360	active site
205922010361	tetramer interface [polypeptide binding]; other site
205922010362	D-galactonate transporter; Region: 2A0114; TIGR00893
205922010363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010364	putative substrate translocation pore; other site
205922010365	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
205922010366	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010367	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
205922010368	putative dimerization interface [polypeptide binding]; other site
205922010369	putative substrate binding pocket [chemical binding]; other site
205922010370	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073
205922010371	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
205922010372	nudix motif; other site
205922010373	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
205922010374	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
205922010375	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
205922010376	NodB motif; other site
205922010377	active site
205922010378	catalytic site [active]
205922010379	metal binding site [ion binding]; metal-binding site
205922010380	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
205922010381	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922010382	membrane-bound complex binding site; other site
205922010383	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
205922010384	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922010385	substrate binding pocket [chemical binding]; other site
205922010386	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
205922010387	membrane-bound complex binding site; other site
205922010388	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922010389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922010390	dimer interface [polypeptide binding]; other site
205922010391	conserved gate region; other site
205922010392	putative PBP binding loops; other site
205922010393	ABC-ATPase subunit interface; other site
205922010394	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
205922010395	Predicted membrane protein [Function unknown]; Region: COG4392
205922010396	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
205922010397	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
205922010398	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
205922010399	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
205922010400	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
205922010401	osmolarity response regulator; Provisional; Region: ompR; PRK09468
205922010402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010403	active site
205922010404	phosphorylation site [posttranslational modification]
205922010405	intermolecular recognition site; other site
205922010406	dimerization interface [polypeptide binding]; other site
205922010407	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922010408	DNA binding site [nucleotide binding]
205922010409	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922010410	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922010411	substrate binding pocket [chemical binding]; other site
205922010412	membrane-bound complex binding site; other site
205922010413	hinge residues; other site
205922010414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
205922010415	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
205922010416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922010417	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
205922010418	non-specific DNA binding site [nucleotide binding]; other site
205922010419	salt bridge; other site
205922010420	sequence-specific DNA binding site [nucleotide binding]; other site
205922010421	Cupin domain; Region: Cupin_2; pfam07883
205922010422	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
205922010423	EamA-like transporter family; Region: EamA; pfam00892
205922010424	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
205922010425	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
205922010426	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
205922010427	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
205922010428	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
205922010429	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
205922010430	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
205922010431	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
205922010432	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
205922010433	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
205922010434	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
205922010435	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
205922010436	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
205922010437	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
205922010438	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922010439	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922010440	N-terminal plug; other site
205922010441	ligand-binding site [chemical binding]; other site
205922010442	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922010443	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
205922010444	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
205922010445	tetrahydrofolate dehydrogenase/cyclohydrolase, putative; Region: PLN02897
205922010446	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922010447	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922010448	dimer interface [polypeptide binding]; other site
205922010449	putative CheW interface [polypeptide binding]; other site
205922010450	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
205922010451	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922010452	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
205922010453	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
205922010454	dimer interface [polypeptide binding]; other site
205922010455	N-terminal domain interface [polypeptide binding]; other site
205922010456	putative substrate binding pocket (H-site) [chemical binding]; other site
205922010457	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
205922010458	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
205922010459	Protein of unknown function (DUF2931); Region: DUF2931; pfam11153
205922010460	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
205922010461	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
205922010462	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
205922010463	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922010464	putative NAD(P) binding site [chemical binding]; other site
205922010465	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922010466	dimerization interface [polypeptide binding]; other site
205922010467	putative DNA binding site [nucleotide binding]; other site
205922010468	putative Zn2+ binding site [ion binding]; other site
205922010469	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010470	Ligand Binding Site [chemical binding]; other site
205922010471	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010472	Ligand Binding Site [chemical binding]; other site
205922010473	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922010474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922010475	Coenzyme A binding pocket [chemical binding]; other site
205922010476	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010477	Ligand Binding Site [chemical binding]; other site
205922010478	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010479	Ligand Binding Site [chemical binding]; other site
205922010480	Predicted membrane protein [Function unknown]; Region: COG3174
205922010481	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
205922010482	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010483	Ligand Binding Site [chemical binding]; other site
205922010484	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010485	Ligand Binding Site [chemical binding]; other site
205922010486	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
205922010487	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922010488	ligand binding site [chemical binding]; other site
205922010489	flexible hinge region; other site
205922010490	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
205922010491	putative switch regulator; other site
205922010492	non-specific DNA interactions [nucleotide binding]; other site
205922010493	DNA binding site [nucleotide binding]
205922010494	sequence specific DNA binding site [nucleotide binding]; other site
205922010495	putative cAMP binding site [chemical binding]; other site
205922010496	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
205922010497	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
205922010498	tetramer interface [polypeptide binding]; other site
205922010499	catalytic Zn binding site [ion binding]; other site
205922010500	NADP binding site [chemical binding]; other site
205922010501	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010502	Ligand Binding Site [chemical binding]; other site
205922010503	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
205922010504	Thermostable hemolysin; Region: T_hemolysin; pfam12261
205922010505	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
205922010506	AMP-binding enzyme; Region: AMP-binding; pfam00501
205922010507	acyl-activating enzyme (AAE) consensus motif; other site
205922010508	putative AMP binding site [chemical binding]; other site
205922010509	putative active site [active]
205922010510	putative CoA binding site [chemical binding]; other site
205922010511	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
205922010512	heme binding pocket [chemical binding]; other site
205922010513	heme ligand [chemical binding]; other site
205922010514	short chain dehydrogenase; Provisional; Region: PRK09072
205922010515	classical (c) SDRs; Region: SDR_c; cd05233
205922010516	NAD(P) binding site [chemical binding]; other site
205922010517	active site
205922010518	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
205922010519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010520	active site
205922010521	phosphorylation site [posttranslational modification]
205922010522	intermolecular recognition site; other site
205922010523	dimerization interface [polypeptide binding]; other site
205922010524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922010525	DNA binding site [nucleotide binding]
205922010526	sensor protein QseC; Provisional; Region: PRK10337
205922010527	HAMP domain; Region: HAMP; pfam00672
205922010528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922010529	dimer interface [polypeptide binding]; other site
205922010530	phosphorylation site [posttranslational modification]
205922010531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922010532	ATP binding site [chemical binding]; other site
205922010533	G-X-G motif; other site
205922010534	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922010535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010536	putative substrate translocation pore; other site
205922010537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922010538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922010540	dimerization interface [polypeptide binding]; other site
205922010541	choline dehydrogenase; Validated; Region: PRK02106
205922010542	lycopene cyclase; Region: lycopene_cycl; TIGR01789
205922010543	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922010544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010545	putative substrate translocation pore; other site
205922010546	Domain of unknown function (DUF427); Region: DUF427; pfam04248
205922010547	H+ Antiporter protein; Region: 2A0121; TIGR00900
205922010548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010549	putative substrate translocation pore; other site
205922010550	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
205922010551	active site
205922010552	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922010553	DNA topoisomerase III; Provisional; Region: PRK07726
205922010554	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
205922010555	active site
205922010556	putative interdomain interaction site [polypeptide binding]; other site
205922010557	putative metal-binding site [ion binding]; other site
205922010558	putative nucleotide binding site [chemical binding]; other site
205922010559	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
205922010560	domain I; other site
205922010561	DNA binding groove [nucleotide binding]
205922010562	phosphate binding site [ion binding]; other site
205922010563	domain II; other site
205922010564	domain III; other site
205922010565	nucleotide binding site [chemical binding]; other site
205922010566	catalytic site [active]
205922010567	domain IV; other site
205922010568	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922010569	Coenzyme A binding pocket [chemical binding]; other site
205922010570	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
205922010571	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010572	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
205922010573	dimerization interface [polypeptide binding]; other site
205922010574	cyanate hydratase; Validated; Region: PRK02866
205922010575	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
205922010576	oligomer interface [polypeptide binding]; other site
205922010577	active site
205922010578	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922010579	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
205922010580	active site clefts [active]
205922010581	zinc binding site [ion binding]; other site
205922010582	dimer interface [polypeptide binding]; other site
205922010583	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
205922010584	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
205922010585	NAD(P) binding site [chemical binding]; other site
205922010586	catalytic residues [active]
205922010587	glutaminase; Provisional; Region: PRK00971
205922010588	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
205922010589	Predicted membrane protein [Function unknown]; Region: COG2259
205922010590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
205922010591	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
205922010592	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
205922010593	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
205922010594	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922010595	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
205922010596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010597	active site
205922010598	phosphorylation site [posttranslational modification]
205922010599	intermolecular recognition site; other site
205922010600	dimerization interface [polypeptide binding]; other site
205922010601	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922010602	DNA binding site [nucleotide binding]
205922010603	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
205922010604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
205922010605	dimerization interface [polypeptide binding]; other site
205922010606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922010607	dimer interface [polypeptide binding]; other site
205922010608	phosphorylation site [posttranslational modification]
205922010609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922010610	ATP binding site [chemical binding]; other site
205922010611	G-X-G motif; other site
205922010612	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
205922010613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010614	putative substrate translocation pore; other site
205922010615	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922010616	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010617	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
205922010618	putative substrate binding pocket [chemical binding]; other site
205922010619	putative dimerization interface [polypeptide binding]; other site
205922010620	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
205922010621	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
205922010622	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
205922010623	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
205922010624	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
205922010625	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
205922010626	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
205922010627	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
205922010628	putative molybdopterin cofactor binding site [chemical binding]; other site
205922010629	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
205922010630	putative molybdopterin cofactor binding site; other site
205922010631	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
205922010632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922010633	FeS/SAM binding site; other site
205922010634	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
205922010635	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
205922010636	sensor protein RstB; Provisional; Region: PRK10604
205922010637	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922010638	dimerization interface [polypeptide binding]; other site
205922010639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922010640	dimer interface [polypeptide binding]; other site
205922010641	phosphorylation site [posttranslational modification]
205922010642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922010643	ATP binding site [chemical binding]; other site
205922010644	Mg2+ binding site [ion binding]; other site
205922010645	G-X-G motif; other site
205922010646	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
205922010647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010648	active site
205922010649	phosphorylation site [posttranslational modification]
205922010650	intermolecular recognition site; other site
205922010651	dimerization interface [polypeptide binding]; other site
205922010652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922010653	DNA binding site [nucleotide binding]
205922010654	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
205922010655	active site
205922010656	dinuclear metal binding site [ion binding]; other site
205922010657	dimerization interface [polypeptide binding]; other site
205922010658	universal stress protein UspE; Provisional; Region: PRK11175
205922010659	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010660	Ligand Binding Site [chemical binding]; other site
205922010661	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922010662	Ligand Binding Site [chemical binding]; other site
205922010663	Predicted Fe-S protein [General function prediction only]; Region: COG3313
205922010664	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
205922010665	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
205922010666	substrate binding site [chemical binding]; other site
205922010667	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
205922010668	substrate binding site [chemical binding]; other site
205922010669	ligand binding site [chemical binding]; other site
205922010670	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
205922010671	serine transporter; Region: stp; TIGR00814
205922010672	active site 1 [active]
205922010673	dimer interface [polypeptide binding]; other site
205922010674	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
205922010675	hexamer interface [polypeptide binding]; other site
205922010676	active site 2 [active]
205922010677	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
205922010678	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205922010679	putative ligand binding site [chemical binding]; other site
205922010680	NAD binding site [chemical binding]; other site
205922010681	catalytic site [active]
205922010682	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
205922010683	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
205922010684	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
205922010685	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
205922010686	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
205922010687	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
205922010688	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
205922010689	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
205922010690	Protein of unknown function (DUF877); Region: DUF877; pfam05943
205922010691	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
205922010692	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
205922010693	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
205922010694	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
205922010695	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
205922010696	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
205922010697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922010698	Walker A motif; other site
205922010699	ATP binding site [chemical binding]; other site
205922010700	Walker B motif; other site
205922010701	arginine finger; other site
205922010702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922010703	Walker A motif; other site
205922010704	ATP binding site [chemical binding]; other site
205922010705	Walker B motif; other site
205922010706	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
205922010707	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922010708	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922010709	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922010710	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
205922010711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
205922010712	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
205922010713	Phosphotransferase enzyme family; Region: APH; pfam01636
205922010714	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
205922010715	putative active site [active]
205922010716	putative substrate binding site [chemical binding]; other site
205922010717	ATP binding site [chemical binding]; other site
205922010718	short chain dehydrogenase; Provisional; Region: PRK07035
205922010719	classical (c) SDRs; Region: SDR_c; cd05233
205922010720	NAD(P) binding site [chemical binding]; other site
205922010721	active site
205922010722	UPF0126 domain; Region: UPF0126; pfam03458
205922010723	Predicted membrane protein [Function unknown]; Region: COG2860
205922010724	UPF0126 domain; Region: UPF0126; pfam03458
205922010725	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
205922010726	PAS domain; Region: PAS_8; pfam13188
205922010727	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922010728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922010729	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922010730	putative active site [active]
205922010731	heme pocket [chemical binding]; other site
205922010732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922010733	putative active site [active]
205922010734	heme pocket [chemical binding]; other site
205922010735	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922010736	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922010737	DNA binding residues [nucleotide binding]
205922010738	dimerization interface [polypeptide binding]; other site
205922010739	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
205922010740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010741	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
205922010742	putative dimerization interface [polypeptide binding]; other site
205922010743	putative substrate binding pocket [chemical binding]; other site
205922010744	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922010745	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922010746	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922010747	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922010748	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922010749	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
205922010750	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
205922010751	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922010752	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922010753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010754	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922010755	dimerization interface [polypeptide binding]; other site
205922010756	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
205922010757	active site
205922010758	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
205922010759	active site
205922010760	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
205922010761	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
205922010762	Flavoprotein; Region: Flavoprotein; pfam02441
205922010763	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
205922010764	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
205922010765	P-loop, Walker A motif; other site
205922010766	Base recognition motif; other site
205922010767	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
205922010768	xanthine permease; Region: pbuX; TIGR03173
205922010769	amidohydrolase; Provisional; Region: PRK12393
205922010770	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
205922010771	active site
205922010772	putative substrate binding pocket [chemical binding]; other site
205922010773	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
205922010774	putative active site [active]
205922010775	putative metal binding site [ion binding]; other site
205922010776	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
205922010777	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922010778	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922010779	DNA binding residues [nucleotide binding]
205922010780	Uncharacterized conserved protein [Function unknown]; Region: COG2128
205922010781	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
205922010782	DHH family; Region: DHH; pfam01368
205922010783	allantoate amidohydrolase; Reviewed; Region: PRK12893
205922010784	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
205922010785	active site
205922010786	metal binding site [ion binding]; metal-binding site
205922010787	dimer interface [polypeptide binding]; other site
205922010788	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
205922010789	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922010790	Na binding site [ion binding]; other site
205922010791	putative substrate binding site [chemical binding]; other site
205922010792	phenylhydantoinase; Validated; Region: PRK08323
205922010793	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
205922010794	tetramer interface [polypeptide binding]; other site
205922010795	active site
205922010796	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
205922010797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922010798	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
205922010799	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
205922010800	homodimer interface [polypeptide binding]; other site
205922010801	active site
205922010802	FMN binding site [chemical binding]; other site
205922010803	substrate binding site [chemical binding]; other site
205922010804	4Fe-4S binding domain; Region: Fer4; cl02805
205922010805	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
205922010806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922010807	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
205922010808	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922010809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922010810	Coenzyme A binding pocket [chemical binding]; other site
205922010811	CopC domain; Region: CopC; pfam04234
205922010812	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
205922010813	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
205922010814	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922010815	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922010816	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
205922010817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010818	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
205922010819	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
205922010820	outer membrane porin, OprD family; Region: OprD; pfam03573
205922010821	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922010822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922010823	active site
205922010824	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
205922010825	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
205922010826	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
205922010827	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
205922010828	DctM-like transporters; Region: DctM; pfam06808
205922010829	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
205922010830	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922010831	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
205922010832	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922010833	putative DNA binding site [nucleotide binding]; other site
205922010834	dimerization interface [polypeptide binding]; other site
205922010835	putative Zn2+ binding site [ion binding]; other site
205922010836	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
205922010837	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
205922010838	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
205922010839	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922010840	putative DNA binding site [nucleotide binding]; other site
205922010841	putative Zn2+ binding site [ion binding]; other site
205922010842	AsnC family; Region: AsnC_trans_reg; pfam01037
205922010843	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
205922010844	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
205922010845	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
205922010846	tetramer interface [polypeptide binding]; other site
205922010847	TPP-binding site [chemical binding]; other site
205922010848	heterodimer interface [polypeptide binding]; other site
205922010849	phosphorylation loop region [posttranslational modification]
205922010850	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
205922010851	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
205922010852	alpha subunit interface [polypeptide binding]; other site
205922010853	TPP binding site [chemical binding]; other site
205922010854	heterodimer interface [polypeptide binding]; other site
205922010855	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205922010856	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
205922010857	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
205922010858	E3 interaction surface; other site
205922010859	lipoyl attachment site [posttranslational modification]; other site
205922010860	e3 binding domain; Region: E3_binding; pfam02817
205922010861	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
205922010862	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
205922010863	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922010864	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205922010865	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
205922010866	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
205922010867	homodimer interface [polypeptide binding]; other site
205922010868	substrate-cofactor binding pocket; other site
205922010869	catalytic residue [active]
205922010870	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
205922010871	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
205922010872	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922010873	FeS/SAM binding site; other site
205922010874	short chain dehydrogenase; Provisional; Region: PRK06500
205922010875	classical (c) SDRs; Region: SDR_c; cd05233
205922010876	NAD(P) binding site [chemical binding]; other site
205922010877	active site
205922010878	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922010879	dimerization interface [polypeptide binding]; other site
205922010880	putative DNA binding site [nucleotide binding]; other site
205922010881	putative Zn2+ binding site [ion binding]; other site
205922010882	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
205922010883	Cytochrome P450; Region: p450; cl12078
205922010884	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
205922010885	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
205922010886	putative metal binding site [ion binding]; other site
205922010887	putative homodimer interface [polypeptide binding]; other site
205922010888	putative homotetramer interface [polypeptide binding]; other site
205922010889	putative homodimer-homodimer interface [polypeptide binding]; other site
205922010890	putative allosteric switch controlling residues; other site
205922010891	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
205922010892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922010893	sequence-specific DNA binding site [nucleotide binding]; other site
205922010894	salt bridge; other site
205922010895	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
205922010896	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
205922010897	catalytic residues [active]
205922010898	catalytic nucleophile [active]
205922010899	Recombinase; Region: Recombinase; pfam07508
205922010900	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
205922010901	Photosystem II protein; Region: PSII; cl08223
205922010902	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
205922010903	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
205922010904	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
205922010905	catalytic residues [active]
205922010906	catalytic nucleophile [active]
205922010907	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922010908	PAS fold; Region: PAS_3; pfam08447
205922010909	putative active site [active]
205922010910	heme pocket [chemical binding]; other site
205922010911	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922010912	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922010913	metal binding site [ion binding]; metal-binding site
205922010914	active site
205922010915	I-site; other site
205922010916	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
205922010917	citrate-proton symporter; Provisional; Region: PRK15075
205922010918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922010919	putative substrate translocation pore; other site
205922010920	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
205922010921	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922010922	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922010923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010924	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
205922010925	putative dimerization interface [polypeptide binding]; other site
205922010926	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
205922010927	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
205922010928	TrkA-N domain; Region: TrkA_N; pfam02254
205922010929	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
205922010930	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922010931	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
205922010932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922010933	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
205922010934	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922010935	catalytic loop [active]
205922010936	iron binding site [ion binding]; other site
205922010937	hypothetical protein; Provisional; Region: PRK10040
205922010938	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922010939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010940	active site
205922010941	phosphorylation site [posttranslational modification]
205922010942	intermolecular recognition site; other site
205922010943	dimerization interface [polypeptide binding]; other site
205922010944	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922010945	DNA binding site [nucleotide binding]
205922010946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922010947	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922010948	dimerization interface [polypeptide binding]; other site
205922010949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922010950	dimer interface [polypeptide binding]; other site
205922010951	phosphorylation site [posttranslational modification]
205922010952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922010953	ATP binding site [chemical binding]; other site
205922010954	Mg2+ binding site [ion binding]; other site
205922010955	G-X-G motif; other site
205922010956	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
205922010957	putative hydrophobic ligand binding site [chemical binding]; other site
205922010958	protein interface [polypeptide binding]; other site
205922010959	gate; other site
205922010960	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
205922010961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922010962	NAD(P) binding site [chemical binding]; other site
205922010963	active site
205922010964	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922010965	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922010966	active site
205922010967	catalytic tetrad [active]
205922010968	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
205922010969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922010970	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
205922010971	dimerization interface [polypeptide binding]; other site
205922010972	substrate binding pocket [chemical binding]; other site
205922010973	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
205922010974	putative active site [active]
205922010975	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
205922010976	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
205922010977	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922010978	catalytic residue [active]
205922010979	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
205922010980	putative phosphatase; Provisional; Region: PRK11587
205922010981	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922010982	motif II; other site
205922010983	Response regulator receiver domain; Region: Response_reg; pfam00072
205922010984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922010985	active site
205922010986	phosphorylation site [posttranslational modification]
205922010987	intermolecular recognition site; other site
205922010988	dimerization interface [polypeptide binding]; other site
205922010989	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
205922010990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922010991	S-adenosylmethionine binding site [chemical binding]; other site
205922010992	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922010993	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922010994	DNA binding residues [nucleotide binding]
205922010995	dimerization interface [polypeptide binding]; other site
205922010996	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922010997	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922010998	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
205922010999	homodimer interface [polypeptide binding]; other site
205922011000	homotetramer interface [polypeptide binding]; other site
205922011001	active site pocket [active]
205922011002	cleavage site
205922011003	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
205922011004	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922011005	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922011006	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922011007	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922011008	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922011009	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205922011010	CoenzymeA binding site [chemical binding]; other site
205922011011	subunit interaction site [polypeptide binding]; other site
205922011012	PHB binding site; other site
205922011013	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922011014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922011015	Coenzyme A binding pocket [chemical binding]; other site
205922011016	YceI-like domain; Region: YceI; pfam04264
205922011017	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
205922011018	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
205922011019	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
205922011020	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
205922011021	active site
205922011022	chorismate mutase; Provisional; Region: PRK09269
205922011023	Chorismate mutase type II; Region: CM_2; cl00693
205922011024	Cache domain; Region: Cache_1; pfam02743
205922011025	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
205922011026	dimerization interface [polypeptide binding]; other site
205922011027	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922011028	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922011029	metal binding site [ion binding]; metal-binding site
205922011030	active site
205922011031	I-site; other site
205922011032	Cytochrome c2 [Energy production and conversion]; Region: COG3474
205922011033	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922011034	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922011035	DNA-binding site [nucleotide binding]; DNA binding site
205922011036	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922011037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922011038	homodimer interface [polypeptide binding]; other site
205922011039	catalytic residue [active]
205922011040	EamA-like transporter family; Region: EamA; pfam00892
205922011041	Cupin; Region: Cupin_6; pfam12852
205922011042	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922011043	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922011044	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922011045	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
205922011046	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
205922011047	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
205922011048	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
205922011049	Sulfate transporter family; Region: Sulfate_transp; pfam00916
205922011050	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
205922011051	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922011052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922011053	Coenzyme A binding pocket [chemical binding]; other site
205922011054	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
205922011055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922011056	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
205922011057	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
205922011058	Isochorismatase family; Region: Isochorismatase; pfam00857
205922011059	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
205922011060	catalytic triad [active]
205922011061	conserved cis-peptide bond; other site
205922011062	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
205922011063	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
205922011064	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
205922011065	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
205922011066	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
205922011067	DNA binding site [nucleotide binding]
205922011068	active site
205922011069	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
205922011070	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
205922011071	dimer interface [polypeptide binding]; other site
205922011072	ADP-ribose binding site [chemical binding]; other site
205922011073	active site
205922011074	nudix motif; other site
205922011075	metal binding site [ion binding]; metal-binding site
205922011076	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
205922011077	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
205922011078	putative active site [active]
205922011079	Chitin binding domain; Region: Chitin_bind_3; pfam03067
205922011080	Hemerythrin-like domain; Region: Hr-like; cd12108
205922011081	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922011082	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205922011083	Coenzyme A binding pocket [chemical binding]; other site
205922011084	Predicted membrane protein [Function unknown]; Region: COG3619
205922011085	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
205922011086	sulfur relay protein TusC; Validated; Region: PRK00211
205922011087	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
205922011088	DsrC like protein; Region: DsrC; cl01101
205922011089	hypothetical protein; Validated; Region: PRK09071
205922011090	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
205922011091	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
205922011092	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
205922011093	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
205922011094	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
205922011095	putative dimer interface [polypeptide binding]; other site
205922011096	N-terminal domain interface [polypeptide binding]; other site
205922011097	putative substrate binding pocket (H-site) [chemical binding]; other site
205922011098	siroheme synthase; Provisional; Region: cysG; PRK10637
205922011099	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
205922011100	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
205922011101	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
205922011102	active site
205922011103	SAM binding site [chemical binding]; other site
205922011104	homodimer interface [polypeptide binding]; other site
205922011105	seryl-tRNA synthetase; Provisional; Region: PRK05431
205922011106	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
205922011107	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
205922011108	dimer interface [polypeptide binding]; other site
205922011109	active site
205922011110	motif 1; other site
205922011111	motif 2; other site
205922011112	motif 3; other site
205922011113	camphor resistance protein CrcB; Provisional; Region: PRK14234
205922011114	recombination factor protein RarA; Reviewed; Region: PRK13342
205922011115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922011116	Walker A motif; other site
205922011117	ATP binding site [chemical binding]; other site
205922011118	Walker B motif; other site
205922011119	arginine finger; other site
205922011120	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
205922011121	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
205922011122	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
205922011123	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
205922011124	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
205922011125	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
205922011126	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
205922011127	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
205922011128	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
205922011129	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
205922011130	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
205922011131	rRNA binding site [nucleotide binding]; other site
205922011132	predicted 30S ribosome binding site; other site
205922011133	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
205922011134	Clp amino terminal domain; Region: Clp_N; pfam02861
205922011135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922011136	Walker A motif; other site
205922011137	ATP binding site [chemical binding]; other site
205922011138	Walker B motif; other site
205922011139	arginine finger; other site
205922011140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922011141	Walker A motif; other site
205922011142	ATP binding site [chemical binding]; other site
205922011143	Walker B motif; other site
205922011144	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
205922011145	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
205922011146	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205922011147	DNA-binding site [nucleotide binding]; DNA binding site
205922011148	RNA-binding motif; other site
205922011149	isocitrate dehydrogenase; Validated; Region: PRK07362
205922011150	isocitrate dehydrogenase; Reviewed; Region: PRK07006
205922011151	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
205922011152	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
205922011153	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
205922011154	nudix motif; other site
205922011155	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
205922011156	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
205922011157	putative lysogenization regulator; Reviewed; Region: PRK00218
205922011158	adenylosuccinate lyase; Provisional; Region: PRK09285
205922011159	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
205922011160	tetramer interface [polypeptide binding]; other site
205922011161	active site
205922011162	Uncharacterized conserved protein [Function unknown]; Region: COG2850
205922011163	Cupin domain; Region: Cupin_2; cl17218
205922011164	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922011165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922011166	Coenzyme A binding pocket [chemical binding]; other site
205922011167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922011168	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
205922011169	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
205922011170	isocitrate lyase; Provisional; Region: PRK15063
205922011171	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
205922011172	tetramer interface [polypeptide binding]; other site
205922011173	active site
205922011174	Mg2+/Mn2+ binding site [ion binding]; other site
205922011175	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
205922011176	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
205922011177	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
205922011178	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
205922011179	NADH dehydrogenase subunit D; Validated; Region: PRK06075
205922011180	NADH dehydrogenase subunit E; Validated; Region: PRK07539
205922011181	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
205922011182	putative dimer interface [polypeptide binding]; other site
205922011183	[2Fe-2S] cluster binding site [ion binding]; other site
205922011184	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
205922011185	SLBB domain; Region: SLBB; pfam10531
205922011186	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
205922011187	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922011188	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
205922011189	catalytic loop [active]
205922011190	iron binding site [ion binding]; other site
205922011191	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
205922011192	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
205922011193	[4Fe-4S] binding site [ion binding]; other site
205922011194	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
205922011195	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
205922011196	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
205922011197	4Fe-4S binding domain; Region: Fer4; pfam00037
205922011198	4Fe-4S binding domain; Region: Fer4; pfam00037
205922011199	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
205922011200	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
205922011201	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
205922011202	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
205922011203	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
205922011204	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
205922011205	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
205922011206	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
205922011207	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
205922011208	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
205922011209	outer membrane porin, OprD family; Region: OprD; pfam03573
205922011210	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922011211	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
205922011212	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
205922011213	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922011214	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
205922011215	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
205922011216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922011217	active site
205922011218	phosphorylation site [posttranslational modification]
205922011219	intermolecular recognition site; other site
205922011220	dimerization interface [polypeptide binding]; other site
205922011221	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922011222	DNA binding site [nucleotide binding]
205922011223	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
205922011224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922011225	dimerization interface [polypeptide binding]; other site
205922011226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922011227	dimer interface [polypeptide binding]; other site
205922011228	phosphorylation site [posttranslational modification]
205922011229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922011230	ATP binding site [chemical binding]; other site
205922011231	Mg2+ binding site [ion binding]; other site
205922011232	G-X-G motif; other site
205922011233	YcaO-like family; Region: YcaO; pfam02624
205922011234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922011235	S-adenosylmethionine binding site [chemical binding]; other site
205922011236	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922011237	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
205922011238	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
205922011239	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
205922011240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922011241	dimer interface [polypeptide binding]; other site
205922011242	conserved gate region; other site
205922011243	putative PBP binding loops; other site
205922011244	ABC-ATPase subunit interface; other site
205922011245	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
205922011246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922011247	putative PBP binding loops; other site
205922011248	dimer interface [polypeptide binding]; other site
205922011249	ABC-ATPase subunit interface; other site
205922011250	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
205922011251	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
205922011252	Walker A/P-loop; other site
205922011253	ATP binding site [chemical binding]; other site
205922011254	Q-loop/lid; other site
205922011255	ABC transporter signature motif; other site
205922011256	Walker B; other site
205922011257	D-loop; other site
205922011258	H-loop/switch region; other site
205922011259	TOBE domain; Region: TOBE_2; pfam08402
205922011260	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
205922011261	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
205922011262	Walker A/P-loop; other site
205922011263	ATP binding site [chemical binding]; other site
205922011264	Q-loop/lid; other site
205922011265	ABC transporter signature motif; other site
205922011266	Walker B; other site
205922011267	D-loop; other site
205922011268	H-loop/switch region; other site
205922011269	TOBE domain; Region: TOBE_2; pfam08402
205922011270	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
205922011271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922011272	Walker A motif; other site
205922011273	ATP binding site [chemical binding]; other site
205922011274	Walker B motif; other site
205922011275	arginine finger; other site
205922011276	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922011277	cation transport protein; Region: 2A0119; TIGR00898
205922011278	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
205922011279	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
205922011280	active site
205922011281	HIGH motif; other site
205922011282	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
205922011283	KMSKS motif; other site
205922011284	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
205922011285	tRNA binding surface [nucleotide binding]; other site
205922011286	anticodon binding site; other site
205922011287	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
205922011288	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205922011289	active site
205922011290	HIGH motif; other site
205922011291	nucleotide binding site [chemical binding]; other site
205922011292	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
205922011293	KMSKS motif; other site
205922011294	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
205922011295	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
205922011296	substrate binding site [chemical binding]; other site
205922011297	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
205922011298	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
205922011299	putative active site [active]
205922011300	putative metal binding site [ion binding]; other site
205922011301	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
205922011302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011303	putative substrate translocation pore; other site
205922011304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011305	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
205922011306	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922011307	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922011308	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
205922011309	MarR family; Region: MarR_2; cl17246
205922011310	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922011311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
205922011312	Family of unknown function (DUF490); Region: DUF490; pfam04357
205922011313	Family of unknown function (DUF490); Region: DUF490; pfam04357
205922011314	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
205922011315	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
205922011316	Surface antigen; Region: Bac_surface_Ag; pfam01103
205922011317	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
205922011318	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
205922011319	putative catalytic site [active]
205922011320	putative phosphate binding site [ion binding]; other site
205922011321	active site
205922011322	metal binding site A [ion binding]; metal-binding site
205922011323	DNA binding site [nucleotide binding]
205922011324	putative AP binding site [nucleotide binding]; other site
205922011325	putative metal binding site B [ion binding]; other site
205922011326	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
205922011327	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922011328	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922011329	ligand binding site [chemical binding]; other site
205922011330	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922011331	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
205922011332	FAD binding site [chemical binding]; other site
205922011333	substrate binding site [chemical binding]; other site
205922011334	catalytic base [active]
205922011335	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
205922011336	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011337	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
205922011338	substrate binding pocket [chemical binding]; other site
205922011339	dimerization interface [polypeptide binding]; other site
205922011340	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
205922011341	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
205922011342	DNA binding residues [nucleotide binding]
205922011343	putative dimer interface [polypeptide binding]; other site
205922011344	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
205922011345	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
205922011346	active site
205922011347	catalytic residues [active]
205922011348	metal binding site [ion binding]; metal-binding site
205922011349	AMP-binding domain protein; Validated; Region: PRK08315
205922011350	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922011351	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
205922011352	acyl-activating enzyme (AAE) consensus motif; other site
205922011353	putative AMP binding site [chemical binding]; other site
205922011354	putative active site [active]
205922011355	putative CoA binding site [chemical binding]; other site
205922011356	isovaleryl-CoA dehydrogenase; Region: PLN02519
205922011357	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
205922011358	substrate binding site [chemical binding]; other site
205922011359	FAD binding site [chemical binding]; other site
205922011360	catalytic base [active]
205922011361	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
205922011362	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
205922011363	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
205922011364	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
205922011365	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922011366	substrate binding site [chemical binding]; other site
205922011367	oxyanion hole (OAH) forming residues; other site
205922011368	trimer interface [polypeptide binding]; other site
205922011369	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
205922011370	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922011371	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205922011372	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
205922011373	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922011374	carboxyltransferase (CT) interaction site; other site
205922011375	biotinylation site [posttranslational modification]; other site
205922011376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922011377	non-specific DNA binding site [nucleotide binding]; other site
205922011378	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
205922011379	salt bridge; other site
205922011380	sequence-specific DNA binding site [nucleotide binding]; other site
205922011381	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
205922011382	Catalytic site [active]
205922011383	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
205922011384	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
205922011385	active site
205922011386	Zn binding site [ion binding]; other site
205922011387	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922011388	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
205922011389	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
205922011390	putative heme binding pocket [chemical binding]; other site
205922011391	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
205922011392	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922011393	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922011394	DNA binding residues [nucleotide binding]
205922011395	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
205922011396	Spore Coat Protein U domain; Region: SCPU; pfam05229
205922011397	Spore Coat Protein U domain; Region: SCPU; pfam05229
205922011398	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
205922011399	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
205922011400	PapC C-terminal domain; Region: PapC_C; pfam13953
205922011401	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
205922011402	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
205922011403	Spore Coat Protein U domain; Region: SCPU; pfam05229
205922011404	Spore Coat Protein U domain; Region: SCPU; pfam05229
205922011405	Spore Coat Protein U domain; Region: SCPU; pfam05229
205922011406	Spore Coat Protein U domain; Region: SCPU; pfam05229
205922011407	Predicted ATPase [General function prediction only]; Region: COG1485
205922011408	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
205922011409	Leucine rich repeat; Region: LRR_8; pfam13855
205922011410	Leucine rich repeat; Region: LRR_8; pfam13855
205922011411	Leucine rich repeat; Region: LRR_8; pfam13855
205922011412	Protein kinase domain; Region: Pkinase; pfam00069
205922011413	Catalytic domain of Protein Kinases; Region: PKc; cd00180
205922011414	active site
205922011415	ATP binding site [chemical binding]; other site
205922011416	substrate binding site [chemical binding]; other site
205922011417	activation loop (A-loop); other site
205922011418	hypothetical protein; Provisional; Region: PRK12378
205922011419	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922011420	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922011421	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922011422	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922011423	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
205922011424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011425	putative substrate translocation pore; other site
205922011426	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
205922011427	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011428	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922011429	dimerization interface [polypeptide binding]; other site
205922011430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011431	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
205922011432	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922011433	dimerization interface [polypeptide binding]; other site
205922011434	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
205922011435	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922011436	catalytic residue [active]
205922011437	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
205922011438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922011439	motif II; other site
205922011440	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
205922011441	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
205922011442	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
205922011443	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922011444	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
205922011445	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
205922011446	active site
205922011447	FMN binding site [chemical binding]; other site
205922011448	2,4-decadienoyl-CoA binding site; other site
205922011449	catalytic residue [active]
205922011450	4Fe-4S cluster binding site [ion binding]; other site
205922011451	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
205922011452	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922011453	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
205922011454	active site
205922011455	catalytic triad [active]
205922011456	Predicted amidohydrolase [General function prediction only]; Region: COG0388
205922011457	dimer interface [polypeptide binding]; other site
205922011458	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922011459	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922011460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922011461	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
205922011462	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922011463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011464	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
205922011465	putative effector binding pocket; other site
205922011466	putative dimerization interface [polypeptide binding]; other site
205922011467	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922011468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011469	putative substrate translocation pore; other site
205922011470	periplasmic folding chaperone; Provisional; Region: PRK10788
205922011471	SurA N-terminal domain; Region: SurA_N_3; pfam13624
205922011472	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
205922011473	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
205922011474	IHF - DNA interface [nucleotide binding]; other site
205922011475	IHF dimer interface [polypeptide binding]; other site
205922011476	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
205922011477	Found in ATP-dependent protease La (LON); Region: LON; smart00464
205922011478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922011479	Walker A motif; other site
205922011480	ATP binding site [chemical binding]; other site
205922011481	Walker B motif; other site
205922011482	arginine finger; other site
205922011483	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
205922011484	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
205922011485	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
205922011486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922011487	Walker A motif; other site
205922011488	ATP binding site [chemical binding]; other site
205922011489	Walker B motif; other site
205922011490	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
205922011491	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
205922011492	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
205922011493	oligomer interface [polypeptide binding]; other site
205922011494	active site residues [active]
205922011495	trigger factor; Provisional; Region: tig; PRK01490
205922011496	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205922011497	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
205922011498	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
205922011499	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
205922011500	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
205922011501	homodimer interface [polypeptide binding]; other site
205922011502	NADP binding site [chemical binding]; other site
205922011503	substrate binding site [chemical binding]; other site
205922011504	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
205922011505	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
205922011506	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
205922011507	putative active site [active]
205922011508	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
205922011509	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
205922011510	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011511	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
205922011512	putative dimerization interface [polypeptide binding]; other site
205922011513	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
205922011514	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011515	putative substrate translocation pore; other site
205922011516	serine/threonine transporter SstT; Provisional; Region: PRK13628
205922011517	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922011518	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
205922011519	Protein of unknown function, DUF480; Region: DUF480; pfam04337
205922011520	Cupin domain; Region: Cupin_2; cl17218
205922011521	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
205922011522	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
205922011523	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
205922011524	shikimate binding site; other site
205922011525	NAD(P) binding site [chemical binding]; other site
205922011526	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
205922011527	Domain of unknown function DUF20; Region: UPF0118; pfam01594
205922011528	putative protease; Provisional; Region: PRK15452
205922011529	Peptidase family U32; Region: Peptidase_U32; pfam01136
205922011530	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922011531	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922011532	DNA-binding site [nucleotide binding]; DNA binding site
205922011533	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
205922011534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011535	D-galactonate transporter; Region: 2A0114; TIGR00893
205922011536	putative substrate translocation pore; other site
205922011537	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
205922011538	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
205922011539	active site
205922011540	tetramer interface [polypeptide binding]; other site
205922011541	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922011542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011543	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
205922011544	putative dimerization interface [polypeptide binding]; other site
205922011545	putative substrate binding pocket [chemical binding]; other site
205922011546	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
205922011547	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
205922011548	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
205922011549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922011550	Walker A/P-loop; other site
205922011551	ATP binding site [chemical binding]; other site
205922011552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
205922011553	Q-loop/lid; other site
205922011554	ABC transporter signature motif; other site
205922011555	Walker B; other site
205922011556	D-loop; other site
205922011557	H-loop/switch region; other site
205922011558	TIGR02646 family protein; Region: TIGR02646
205922011559	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
205922011560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922011561	Coenzyme A binding pocket [chemical binding]; other site
205922011562	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922011563	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
205922011564	active site
205922011565	catalytic residues [active]
205922011566	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922011567	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922011568	active site
205922011569	catalytic tetrad [active]
205922011570	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
205922011571	DNA polymerase II; Reviewed; Region: PRK05762
205922011572	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
205922011573	active site
205922011574	catalytic site [active]
205922011575	substrate binding site [chemical binding]; other site
205922011576	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
205922011577	active site
205922011578	metal-binding site
205922011579	FOG: CBS domain [General function prediction only]; Region: COG0517
205922011580	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
205922011581	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922011582	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
205922011583	C-terminal domain interface [polypeptide binding]; other site
205922011584	GSH binding site (G-site) [chemical binding]; other site
205922011585	dimer interface [polypeptide binding]; other site
205922011586	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
205922011587	dimer interface [polypeptide binding]; other site
205922011588	N-terminal domain interface [polypeptide binding]; other site
205922011589	substrate binding pocket (H-site) [chemical binding]; other site
205922011590	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
205922011591	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
205922011592	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
205922011593	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
205922011594	TolR protein; Region: tolR; TIGR02801
205922011595	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
205922011596	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922011597	N-terminal plug; other site
205922011598	ligand-binding site [chemical binding]; other site
205922011599	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
205922011600	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
205922011601	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
205922011602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922011603	dimer interface [polypeptide binding]; other site
205922011604	conserved gate region; other site
205922011605	putative PBP binding loops; other site
205922011606	ABC-ATPase subunit interface; other site
205922011607	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
205922011608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922011609	dimer interface [polypeptide binding]; other site
205922011610	conserved gate region; other site
205922011611	putative PBP binding loops; other site
205922011612	ABC-ATPase subunit interface; other site
205922011613	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
205922011614	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922011615	Walker A/P-loop; other site
205922011616	ATP binding site [chemical binding]; other site
205922011617	Q-loop/lid; other site
205922011618	ABC transporter signature motif; other site
205922011619	Walker B; other site
205922011620	D-loop; other site
205922011621	H-loop/switch region; other site
205922011622	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
205922011623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
205922011624	Walker A/P-loop; other site
205922011625	ATP binding site [chemical binding]; other site
205922011626	Q-loop/lid; other site
205922011627	ABC transporter signature motif; other site
205922011628	Walker B; other site
205922011629	D-loop; other site
205922011630	H-loop/switch region; other site
205922011631	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
205922011632	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
205922011633	RNA polymerase sigma factor; Provisional; Region: PRK12537
205922011634	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922011635	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922011636	DNA binding residues [nucleotide binding]
205922011637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
205922011638	Anti-sigma-K factor rskA; Region: RskA; pfam10099
205922011639	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
205922011640	hypothetical protein; Provisional; Region: PRK06184
205922011641	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
205922011642	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
205922011643	dimer interface [polypeptide binding]; other site
205922011644	active site
205922011645	Schiff base residues; other site
205922011646	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
205922011647	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
205922011648	C-terminal domain interface [polypeptide binding]; other site
205922011649	GSH binding site (G-site) [chemical binding]; other site
205922011650	dimer interface [polypeptide binding]; other site
205922011651	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
205922011652	dimer interface [polypeptide binding]; other site
205922011653	N-terminal domain interface [polypeptide binding]; other site
205922011654	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
205922011655	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
205922011656	active site residue [active]
205922011657	selenophosphate synthetase; Provisional; Region: PRK00943
205922011658	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
205922011659	dimerization interface [polypeptide binding]; other site
205922011660	putative ATP binding site [chemical binding]; other site
205922011661	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922011662	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922011663	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922011664	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922011665	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
205922011666	Autotransporter beta-domain; Region: Autotransporter; pfam03797
205922011667	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
205922011668	Purine nucleoside permease (NUP); Region: NUP; pfam06516
205922011669	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922011670	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
205922011671	putative NAD(P) binding site [chemical binding]; other site
205922011672	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
205922011673	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922011674	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922011675	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922011676	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
205922011677	Protein of unknown function, DUF606; Region: DUF606; pfam04657
205922011678	Protein of unknown function, DUF606; Region: DUF606; pfam04657
205922011679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922011680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011681	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922011682	putative effector binding pocket; other site
205922011683	dimerization interface [polypeptide binding]; other site
205922011684	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
205922011685	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922011686	dimerization interface [polypeptide binding]; other site
205922011687	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922011688	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922011689	dimer interface [polypeptide binding]; other site
205922011690	putative CheW interface [polypeptide binding]; other site
205922011691	Predicted permease [General function prediction only]; Region: COG2056
205922011692	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
205922011693	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922011694	dimerization interface [polypeptide binding]; other site
205922011695	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922011696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922011697	dimer interface [polypeptide binding]; other site
205922011698	putative CheW interface [polypeptide binding]; other site
205922011699	sensor protein PhoQ; Provisional; Region: PRK10815
205922011700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922011701	ATP binding site [chemical binding]; other site
205922011702	G-X-G motif; other site
205922011703	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922011704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922011705	active site
205922011706	phosphorylation site [posttranslational modification]
205922011707	intermolecular recognition site; other site
205922011708	dimerization interface [polypeptide binding]; other site
205922011709	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922011710	DNA binding site [nucleotide binding]
205922011711	Predicted membrane protein [Function unknown]; Region: COG3212
205922011712	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205922011713	Predicted membrane protein [Function unknown]; Region: COG3212
205922011714	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205922011715	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
205922011716	active site
205922011717	cytosine permease; Provisional; Region: codB; PRK11017
205922011718	Na binding site [ion binding]; other site
205922011719	cytosine deaminase; Provisional; Region: PRK09230
205922011720	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
205922011721	active site
205922011722	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
205922011723	diaminopimelate epimerase; Provisional; Region: PRK13577
205922011724	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
205922011725	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922011726	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
205922011727	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922011728	N-terminal plug; other site
205922011729	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922011730	FecR protein; Region: FecR; pfam04773
205922011731	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922011732	RNA polymerase sigma factor; Reviewed; Region: PRK12527
205922011733	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922011734	DNA binding residues [nucleotide binding]
205922011735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922011736	S-adenosylmethionine binding site [chemical binding]; other site
205922011737	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
205922011738	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922011739	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
205922011740	haemagglutination activity domain; Region: Haemagg_act; pfam05860
205922011741	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
205922011742	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
205922011743	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
205922011744	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
205922011745	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
205922011746	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
205922011747	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
205922011748	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
205922011749	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
205922011750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922011751	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922011752	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
205922011753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011754	putative substrate translocation pore; other site
205922011755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011756	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
205922011757	Uncharacterized conserved protein [Function unknown]; Region: COG2128
205922011758	RNA polymerase sigma factor; Provisional; Region: PRK12528
205922011759	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922011760	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922011761	DNA binding residues [nucleotide binding]
205922011762	fec operon regulator FecR; Reviewed; Region: PRK09774
205922011763	FecR protein; Region: FecR; pfam04773
205922011764	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922011765	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
205922011766	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922011767	N-terminal plug; other site
205922011768	ligand-binding site [chemical binding]; other site
205922011769	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922011770	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922011771	metal binding site [ion binding]; metal-binding site
205922011772	active site
205922011773	I-site; other site
205922011774	hypothetical protein; Provisional; Region: PRK06486
205922011775	intersubunit interface [polypeptide binding]; other site
205922011776	active site
205922011777	Zn2+ binding site [ion binding]; other site
205922011778	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
205922011779	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922011780	motif II; other site
205922011781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922011782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922011783	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922011784	dimerization interface [polypeptide binding]; other site
205922011785	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922011786	PAAR motif; Region: PAAR_motif; pfam05488
205922011787	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
205922011788	B1 nucleotide binding pocket [chemical binding]; other site
205922011789	B2 nucleotide binding pocket [chemical binding]; other site
205922011790	CAS motifs; other site
205922011791	active site
205922011792	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
205922011793	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
205922011794	Multicopper oxidase; Region: Cu-oxidase; pfam00394
205922011795	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
205922011796	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
205922011797	CopC domain; Region: CopC; pfam04234
205922011798	Copper resistance protein D; Region: CopD; pfam05425
205922011799	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922011800	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922011801	substrate binding pocket [chemical binding]; other site
205922011802	membrane-bound complex binding site; other site
205922011803	hinge residues; other site
205922011804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
205922011805	Transposase; Region: DEDD_Tnp_IS110; pfam01548
205922011806	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
205922011807	PAAR motif; Region: PAAR_motif; pfam05488
205922011808	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
205922011809	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
205922011810	FMN binding site [chemical binding]; other site
205922011811	active site
205922011812	catalytic residues [active]
205922011813	substrate binding site [chemical binding]; other site
205922011814	Protein of unknown function (DUF2388); Region: DUF2388; cl09731
205922011815	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
205922011816	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922011817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922011818	DNA binding site [nucleotide binding]
205922011819	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922011820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
205922011821	DNA binding site [nucleotide binding]
205922011822	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
205922011823	Bacterial sugar transferase; Region: Bac_transf; pfam02397
205922011824	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
205922011825	SLBB domain; Region: SLBB; pfam10531
205922011826	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
205922011827	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
205922011828	polysaccharide export protein Wza; Provisional; Region: PRK15078
205922011829	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
205922011830	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
205922011831	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
205922011832	NAD binding site [chemical binding]; other site
205922011833	homodimer interface [polypeptide binding]; other site
205922011834	active site
205922011835	substrate binding site [chemical binding]; other site
205922011836	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
205922011837	active site
205922011838	tetramer interface; other site
205922011839	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
205922011840	active site
205922011841	oxyanion hole [active]
205922011842	catalytic triad [active]
205922011843	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
205922011844	Acyltransferase family; Region: Acyl_transf_3; pfam01757
205922011845	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126
205922011846	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
205922011847	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922011848	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
205922011849	putative ADP-binding pocket [chemical binding]; other site
205922011850	tyrosine kinase; Provisional; Region: PRK11519
205922011851	Chain length determinant protein; Region: Wzz; pfam02706
205922011852	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
205922011853	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
205922011854	P loop; other site
205922011855	Nucleotide binding site [chemical binding]; other site
205922011856	DTAP/Switch II; other site
205922011857	Switch I; other site
205922011858	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
205922011859	Low molecular weight phosphatase family; Region: LMWPc; cd00115
205922011860	active site
205922011861	transaldolase-like protein; Provisional; Region: PTZ00411
205922011862	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
205922011863	active site
205922011864	dimer interface [polypeptide binding]; other site
205922011865	catalytic residue [active]
205922011866	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
205922011867	anti sigma factor interaction site; other site
205922011868	regulatory phosphorylation site [posttranslational modification]; other site
205922011869	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922011870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922011871	active site
205922011872	phosphorylation site [posttranslational modification]
205922011873	intermolecular recognition site; other site
205922011874	dimerization interface [polypeptide binding]; other site
205922011875	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
205922011876	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
205922011877	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
205922011878	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
205922011879	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
205922011880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
205922011881	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
205922011882	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
205922011883	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
205922011884	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
205922011885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922011886	active site
205922011887	phosphorylation site [posttranslational modification]
205922011888	intermolecular recognition site; other site
205922011889	dimerization interface [polypeptide binding]; other site
205922011890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922011891	DNA binding site [nucleotide binding]
205922011892	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
205922011893	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922011894	dimerization interface [polypeptide binding]; other site
205922011895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922011896	dimer interface [polypeptide binding]; other site
205922011897	phosphorylation site [posttranslational modification]
205922011898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922011899	ATP binding site [chemical binding]; other site
205922011900	Mg2+ binding site [ion binding]; other site
205922011901	G-X-G motif; other site
205922011902	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
205922011903	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205922011904	FtsX-like permease family; Region: FtsX; pfam02687
205922011905	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
205922011906	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205922011907	Walker A/P-loop; other site
205922011908	ATP binding site [chemical binding]; other site
205922011909	Q-loop/lid; other site
205922011910	ABC transporter signature motif; other site
205922011911	Walker B; other site
205922011912	D-loop; other site
205922011913	H-loop/switch region; other site
205922011914	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
205922011915	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205922011916	FtsX-like permease family; Region: FtsX; pfam02687
205922011917	PilZ domain; Region: PilZ; pfam07238
205922011918	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
205922011919	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
205922011920	active site
205922011921	catalytic site [active]
205922011922	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
205922011923	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922011924	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205922011925	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
205922011926	ApbE family; Region: ApbE; pfam02424
205922011927	citrate-proton symporter; Provisional; Region: PRK15075
205922011928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922011929	putative substrate translocation pore; other site
205922011930	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
205922011931	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
205922011932	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
205922011933	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
205922011934	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
205922011935	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922011936	ATP binding site [chemical binding]; other site
205922011937	putative Mg++ binding site [ion binding]; other site
205922011938	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922011939	nucleotide binding region [chemical binding]; other site
205922011940	ATP-binding site [chemical binding]; other site
205922011941	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
205922011942	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
205922011943	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
205922011944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922011945	ATP binding site [chemical binding]; other site
205922011946	putative Mg++ binding site [ion binding]; other site
205922011947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922011948	nucleotide binding region [chemical binding]; other site
205922011949	ATP-binding site [chemical binding]; other site
205922011950	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
205922011951	beta-hexosaminidase; Provisional; Region: PRK05337
205922011952	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
205922011953	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922011954	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922011955	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
205922011956	LexA repressor; Validated; Region: PRK00215
205922011957	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
205922011958	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
205922011959	Catalytic site [active]
205922011960	Cell division inhibitor SulA; Region: SulA; cl01880
205922011961	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
205922011962	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
205922011963	active site
205922011964	interdomain interaction site; other site
205922011965	putative metal-binding site [ion binding]; other site
205922011966	nucleotide binding site [chemical binding]; other site
205922011967	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
205922011968	domain I; other site
205922011969	DNA binding groove [nucleotide binding]
205922011970	phosphate binding site [ion binding]; other site
205922011971	domain II; other site
205922011972	domain III; other site
205922011973	nucleotide binding site [chemical binding]; other site
205922011974	catalytic site [active]
205922011975	domain IV; other site
205922011976	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
205922011977	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
205922011978	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
205922011979	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
205922011980	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
205922011981	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
205922011982	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922011983	dimer interface [polypeptide binding]; other site
205922011984	active site
205922011985	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
205922011986	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922011987	substrate binding site [chemical binding]; other site
205922011988	oxyanion hole (OAH) forming residues; other site
205922011989	trimer interface [polypeptide binding]; other site
205922011990	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922011991	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922011992	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922011993	Ligand Binding Site [chemical binding]; other site
205922011994	ABC transporter ATPase component; Reviewed; Region: PRK11147
205922011995	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922011996	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922011997	ABC transporter; Region: ABC_tran_2; pfam12848
205922011998	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922011999	lytic murein transglycosylase; Provisional; Region: PRK11619
205922012000	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922012001	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922012002	catalytic residue [active]
205922012003	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
205922012004	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922012005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922012006	Walker A/P-loop; other site
205922012007	ATP binding site [chemical binding]; other site
205922012008	Q-loop/lid; other site
205922012009	ABC transporter signature motif; other site
205922012010	Walker B; other site
205922012011	D-loop; other site
205922012012	H-loop/switch region; other site
205922012013	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
205922012014	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
205922012015	ligand binding site [chemical binding]; other site
205922012016	NAD binding site [chemical binding]; other site
205922012017	catalytic site [active]
205922012018	homodimer interface [polypeptide binding]; other site
205922012019	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
205922012020	multidrug efflux protein; Reviewed; Region: PRK01766
205922012021	cation binding site [ion binding]; other site
205922012022	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
205922012023	CPxP  motif; other site
205922012024	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
205922012025	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
205922012026	aconitate hydratase; Validated; Region: PRK09277
205922012027	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
205922012028	substrate binding site [chemical binding]; other site
205922012029	ligand binding site [chemical binding]; other site
205922012030	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
205922012031	substrate binding site [chemical binding]; other site
205922012032	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
205922012033	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
205922012034	putative hydrophobic ligand binding site [chemical binding]; other site
205922012035	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
205922012036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
205922012037	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
205922012038	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
205922012039	active site
205922012040	Zn binding site [ion binding]; other site
205922012041	allantoate amidohydrolase; Reviewed; Region: PRK12893
205922012042	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
205922012043	active site
205922012044	metal binding site [ion binding]; metal-binding site
205922012045	dimer interface [polypeptide binding]; other site
205922012046	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922012047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922012048	putative substrate translocation pore; other site
205922012049	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922012050	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922012051	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922012052	dimerization interface [polypeptide binding]; other site
205922012053	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
205922012054	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
205922012055	putative ligand binding site [chemical binding]; other site
205922012056	NAD binding site [chemical binding]; other site
205922012057	dimerization interface [polypeptide binding]; other site
205922012058	catalytic site [active]
205922012059	aldolase II superfamily protein; Provisional; Region: PRK07044
205922012060	intersubunit interface [polypeptide binding]; other site
205922012061	active site
205922012062	Zn2+ binding site [ion binding]; other site
205922012063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922012064	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922012065	putative substrate translocation pore; other site
205922012066	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922012067	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922012068	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922012069	dimerization interface [polypeptide binding]; other site
205922012070	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
205922012071	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
205922012072	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
205922012073	threonine and homoserine efflux system; Provisional; Region: PRK10532
205922012074	EamA-like transporter family; Region: EamA; pfam00892
205922012075	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922012076	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922012077	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
205922012078	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
205922012079	putative NAD(P) binding site [chemical binding]; other site
205922012080	active site
205922012081	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
205922012082	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
205922012083	putative catalytic residue [active]
205922012084	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
205922012085	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922012086	putative NAD(P) binding site [chemical binding]; other site
205922012087	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922012088	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922012089	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922012090	putative effector binding pocket; other site
205922012091	dimerization interface [polypeptide binding]; other site
205922012092	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
205922012093	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
205922012094	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
205922012095	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
205922012096	active site
205922012097	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
205922012098	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
205922012099	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922012100	catalytic residue [active]
205922012101	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922012102	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922012103	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
205922012104	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
205922012105	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
205922012106	active site
205922012107	dimer interface [polypeptide binding]; other site
205922012108	non-prolyl cis peptide bond; other site
205922012109	insertion regions; other site
205922012110	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
205922012111	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
205922012112	Flavin binding site [chemical binding]; other site
205922012113	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
205922012114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922012115	Walker A motif; other site
205922012116	ATP binding site [chemical binding]; other site
205922012117	Walker B motif; other site
205922012118	arginine finger; other site
205922012119	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
205922012120	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
205922012121	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
205922012122	DNA binding residues [nucleotide binding]
205922012123	dimer interface [polypeptide binding]; other site
205922012124	[2Fe-2S] cluster binding site [ion binding]; other site
205922012125	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
205922012126	putative dimer interface [polypeptide binding]; other site
205922012127	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
205922012128	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
205922012129	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
205922012130	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
205922012131	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205922012132	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
205922012133	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
205922012134	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
205922012135	metal binding site [ion binding]; metal-binding site
205922012136	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
205922012137	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
205922012138	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
205922012139	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205922012140	ABC-ATPase subunit  interface; other site
205922012141	dimer interface [polypeptide binding]; other site
205922012142	putative PBP binding regions; other site
205922012143	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
205922012144	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
205922012145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
205922012146	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
205922012147	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922012148	inhibitor-cofactor binding pocket; inhibition site
205922012149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012150	catalytic residue [active]
205922012151	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922012152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922012153	Coenzyme A binding pocket [chemical binding]; other site
205922012154	sensor protein QseC; Provisional; Region: PRK10337
205922012155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922012156	dimer interface [polypeptide binding]; other site
205922012157	phosphorylation site [posttranslational modification]
205922012158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922012159	ATP binding site [chemical binding]; other site
205922012160	G-X-G motif; other site
205922012161	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
205922012162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012163	active site
205922012164	phosphorylation site [posttranslational modification]
205922012165	intermolecular recognition site; other site
205922012166	dimerization interface [polypeptide binding]; other site
205922012167	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922012168	DNA binding site [nucleotide binding]
205922012169	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
205922012170	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
205922012171	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
205922012172	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
205922012173	DsbD alpha interface [polypeptide binding]; other site
205922012174	catalytic residues [active]
205922012175	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
205922012176	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
205922012177	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205922012178	catalytic residues [active]
205922012179	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
205922012180	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
205922012181	dimerization domain [polypeptide binding]; other site
205922012182	dimer interface [polypeptide binding]; other site
205922012183	catalytic residues [active]
205922012184	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
205922012185	PGAP1-like protein; Region: PGAP1; pfam07819
205922012186	peptide synthase; Validated; Region: PRK05691
205922012187	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
205922012188	acyl-activating enzyme (AAE) consensus motif; other site
205922012189	active site
205922012190	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922012191	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922012192	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922012193	acyl-activating enzyme (AAE) consensus motif; other site
205922012194	AMP binding site [chemical binding]; other site
205922012195	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922012196	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922012197	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922012198	acyl-activating enzyme (AAE) consensus motif; other site
205922012199	AMP binding site [chemical binding]; other site
205922012200	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922012201	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
205922012202	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
205922012203	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
205922012204	acyl-activating enzyme (AAE) consensus motif; other site
205922012205	AMP binding site [chemical binding]; other site
205922012206	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
205922012207	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
205922012208	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922012209	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922012210	DNA binding residues [nucleotide binding]
205922012211	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
205922012212	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
205922012213	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922012214	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922012215	substrate binding pocket [chemical binding]; other site
205922012216	membrane-bound complex binding site; other site
205922012217	hinge residues; other site
205922012218	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922012219	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922012220	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
205922012221	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
205922012222	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
205922012223	NAD(P) binding site [chemical binding]; other site
205922012224	substrate binding site [chemical binding]; other site
205922012225	homotetramer interface [polypeptide binding]; other site
205922012226	active site
205922012227	homodimer interface [polypeptide binding]; other site
205922012228	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
205922012229	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
205922012230	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
205922012231	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922012232	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922012233	active site
205922012234	enoyl-CoA hydratase; Provisional; Region: PRK05995
205922012235	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922012236	substrate binding site [chemical binding]; other site
205922012237	oxyanion hole (OAH) forming residues; other site
205922012238	trimer interface [polypeptide binding]; other site
205922012239	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
205922012240	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922012241	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205922012242	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
205922012243	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922012244	carboxyltransferase (CT) interaction site; other site
205922012245	biotinylation site [posttranslational modification]; other site
205922012246	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
205922012247	active site
205922012248	catalytic site [active]
205922012249	substrate binding site [chemical binding]; other site
205922012250	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
205922012251	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
205922012252	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
205922012253	MOSC domain; Region: MOSC; pfam03473
205922012254	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
205922012255	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922012256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012257	active site
205922012258	phosphorylation site [posttranslational modification]
205922012259	intermolecular recognition site; other site
205922012260	dimerization interface [polypeptide binding]; other site
205922012261	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
205922012262	Histidine kinase; Region: HisKA_3; pfam07730
205922012263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922012264	ATP binding site [chemical binding]; other site
205922012265	Mg2+ binding site [ion binding]; other site
205922012266	G-X-G motif; other site
205922012267	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922012268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012269	active site
205922012270	phosphorylation site [posttranslational modification]
205922012271	intermolecular recognition site; other site
205922012272	dimerization interface [polypeptide binding]; other site
205922012273	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922012274	DNA binding residues [nucleotide binding]
205922012275	dimerization interface [polypeptide binding]; other site
205922012276	lipid kinase; Reviewed; Region: PRK13054
205922012277	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
205922012278	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
205922012279	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
205922012280	dimer interface [polypeptide binding]; other site
205922012281	putative functional site; other site
205922012282	putative MPT binding site; other site
205922012283	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
205922012284	MPT binding site; other site
205922012285	trimer interface [polypeptide binding]; other site
205922012286	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
205922012287	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
205922012288	GTP binding site; other site
205922012289	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
205922012290	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
205922012291	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
205922012292	probable active site [active]
205922012293	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
205922012294	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
205922012295	TrkA-N domain; Region: TrkA_N; pfam02254
205922012296	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
205922012297	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
205922012298	Predicted membrane protein [Function unknown]; Region: COG5393
205922012299	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922012300	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
205922012301	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
205922012302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
205922012303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922012304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012305	active site
205922012306	phosphorylation site [posttranslational modification]
205922012307	intermolecular recognition site; other site
205922012308	dimerization interface [polypeptide binding]; other site
205922012309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922012310	DNA binding residues [nucleotide binding]
205922012311	dimerization interface [polypeptide binding]; other site
205922012312	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
205922012313	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922012314	substrate binding pocket [chemical binding]; other site
205922012315	membrane-bound complex binding site; other site
205922012316	hinge residues; other site
205922012317	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922012318	substrate binding pocket [chemical binding]; other site
205922012319	membrane-bound complex binding site; other site
205922012320	hinge residues; other site
205922012321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922012322	putative active site [active]
205922012323	heme pocket [chemical binding]; other site
205922012324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922012325	dimer interface [polypeptide binding]; other site
205922012326	phosphorylation site [posttranslational modification]
205922012327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922012328	ATP binding site [chemical binding]; other site
205922012329	Mg2+ binding site [ion binding]; other site
205922012330	G-X-G motif; other site
205922012331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012332	active site
205922012333	phosphorylation site [posttranslational modification]
205922012334	intermolecular recognition site; other site
205922012335	dimerization interface [polypeptide binding]; other site
205922012336	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922012337	putative binding surface; other site
205922012338	active site
205922012339	GAF domain; Region: GAF_3; pfam13492
205922012340	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922012341	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
205922012342	GAF domain; Region: GAF_2; pfam13185
205922012343	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
205922012344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922012345	Walker A motif; other site
205922012346	ATP binding site [chemical binding]; other site
205922012347	Walker B motif; other site
205922012348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922012349	dimer interface [polypeptide binding]; other site
205922012350	phosphorylation site [posttranslational modification]
205922012351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922012352	ATP binding site [chemical binding]; other site
205922012353	Mg2+ binding site [ion binding]; other site
205922012354	G-X-G motif; other site
205922012355	Response regulator receiver domain; Region: Response_reg; pfam00072
205922012356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012357	active site
205922012358	phosphorylation site [posttranslational modification]
205922012359	intermolecular recognition site; other site
205922012360	dimerization interface [polypeptide binding]; other site
205922012361	Transcriptional regulators [Transcription]; Region: MarR; COG1846
205922012362	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
205922012363	catalytic residues [active]
205922012364	dimer interface [polypeptide binding]; other site
205922012365	methionine sulfoxide reductase B; Provisional; Region: PRK00222
205922012366	SelR domain; Region: SelR; pfam01641
205922012367	aminotransferase AlaT; Validated; Region: PRK09265
205922012368	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922012369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012370	homodimer interface [polypeptide binding]; other site
205922012371	catalytic residue [active]
205922012372	heat shock protein HtpX; Provisional; Region: PRK05457
205922012373	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
205922012374	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
205922012375	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
205922012376	putative active site [active]
205922012377	metal binding site [ion binding]; metal-binding site
205922012378	helicase 45; Provisional; Region: PTZ00424
205922012379	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205922012380	ATP binding site [chemical binding]; other site
205922012381	Mg++ binding site [ion binding]; other site
205922012382	motif III; other site
205922012383	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922012384	nucleotide binding region [chemical binding]; other site
205922012385	ATP-binding site [chemical binding]; other site
205922012386	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
205922012387	enoyl-CoA hydratase; Provisional; Region: PRK06563
205922012388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922012389	substrate binding site [chemical binding]; other site
205922012390	oxyanion hole (OAH) forming residues; other site
205922012391	trimer interface [polypeptide binding]; other site
205922012392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922012393	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
205922012394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
205922012395	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
205922012396	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
205922012397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922012398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922012399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922012400	dimerization interface [polypeptide binding]; other site
205922012401	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922012402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922012403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922012404	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922012405	putative effector binding pocket; other site
205922012406	dimerization interface [polypeptide binding]; other site
205922012407	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
205922012408	MarR family; Region: MarR; pfam01047
205922012409	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
205922012410	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
205922012411	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
205922012412	substrate binding pocket [chemical binding]; other site
205922012413	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922012414	elongation factor P; Validated; Region: PRK00529
205922012415	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
205922012416	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
205922012417	RNA binding site [nucleotide binding]; other site
205922012418	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
205922012419	RNA binding site [nucleotide binding]; other site
205922012420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
205922012421	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
205922012422	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
205922012423	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
205922012424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922012425	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
205922012426	substrate binding site [chemical binding]; other site
205922012427	dimerization interface [polypeptide binding]; other site
205922012428	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
205922012429	Ligand Binding Site [chemical binding]; other site
205922012430	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
205922012431	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
205922012432	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
205922012433	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
205922012434	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205922012435	catalytic residues [active]
205922012436	PilZ domain; Region: PilZ; cl01260
205922012437	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
205922012438	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
205922012439	Predicted acetyltransferase [General function prediction only]; Region: COG2388
205922012440	L,D-transpeptidase; Provisional; Region: PRK10260
205922012441	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
205922012442	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
205922012443	active site
205922012444	catalytic triad [active]
205922012445	oxyanion hole [active]
205922012446	switch loop; other site
205922012447	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
205922012448	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205922012449	Walker A/P-loop; other site
205922012450	ATP binding site [chemical binding]; other site
205922012451	Q-loop/lid; other site
205922012452	ABC transporter signature motif; other site
205922012453	Walker B; other site
205922012454	D-loop; other site
205922012455	H-loop/switch region; other site
205922012456	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
205922012457	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
205922012458	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
205922012459	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
205922012460	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
205922012461	Predicted membrane protein [Function unknown]; Region: COG2259
205922012462	Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623
205922012463	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922012464	substrate binding pocket [chemical binding]; other site
205922012465	membrane-bound complex binding site; other site
205922012466	hinge residues; other site
205922012467	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922012468	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922012469	catalytic residue [active]
205922012470	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
205922012471	active site
205922012472	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922012473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922012474	dimerization interface [polypeptide binding]; other site
205922012475	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922012476	dimer interface [polypeptide binding]; other site
205922012477	putative CheW interface [polypeptide binding]; other site
205922012478	Terminase small subunit; Region: Terminase_2; cl01513
205922012479	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
205922012480	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
205922012481	active site
205922012482	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
205922012483	active site 2 [active]
205922012484	active site 1 [active]
205922012485	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
205922012486	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
205922012487	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
205922012488	active site
205922012489	nucleophile elbow; other site
205922012490	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
205922012491	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
205922012492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922012493	active site
205922012494	phosphorylation site [posttranslational modification]
205922012495	intermolecular recognition site; other site
205922012496	dimerization interface [polypeptide binding]; other site
205922012497	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922012498	DNA binding site [nucleotide binding]
205922012499	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
205922012500	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
205922012501	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
205922012502	Ligand Binding Site [chemical binding]; other site
205922012503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922012504	dimer interface [polypeptide binding]; other site
205922012505	phosphorylation site [posttranslational modification]
205922012506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922012507	ATP binding site [chemical binding]; other site
205922012508	Mg2+ binding site [ion binding]; other site
205922012509	G-X-G motif; other site
205922012510	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
205922012511	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
205922012512	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205922012513	Soluble P-type ATPase [General function prediction only]; Region: COG4087
205922012514	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
205922012515	ethanolamine permease; Region: 2A0305; TIGR00908
205922012516	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
205922012517	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
205922012518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922012519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922012520	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205922012521	dimer interface [polypeptide binding]; other site
205922012522	active site
205922012523	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
205922012524	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
205922012525	classical (c) SDRs; Region: SDR_c; cd05233
205922012526	NAD(P) binding site [chemical binding]; other site
205922012527	active site
205922012528	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
205922012529	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922012530	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
205922012531	active site
205922012532	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922012533	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
205922012534	active site
205922012535	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
205922012536	dimer interaction site [polypeptide binding]; other site
205922012537	substrate-binding tunnel; other site
205922012538	active site
205922012539	catalytic site [active]
205922012540	substrate binding site [chemical binding]; other site
205922012541	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
205922012542	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
205922012543	putative trimer interface [polypeptide binding]; other site
205922012544	putative CoA binding site [chemical binding]; other site
205922012545	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
205922012546	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
205922012547	inhibitor-cofactor binding pocket; inhibition site
205922012548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012549	catalytic residue [active]
205922012550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922012551	S-adenosylmethionine binding site [chemical binding]; other site
205922012552	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
205922012553	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
205922012554	Walker A/P-loop; other site
205922012555	ATP binding site [chemical binding]; other site
205922012556	Q-loop/lid; other site
205922012557	ABC transporter signature motif; other site
205922012558	Walker B; other site
205922012559	D-loop; other site
205922012560	H-loop/switch region; other site
205922012561	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
205922012562	putative carbohydrate binding site [chemical binding]; other site
205922012563	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
205922012564	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
205922012565	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
205922012566	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
205922012567	NAD(P) binding site [chemical binding]; other site
205922012568	homodimer interface [polypeptide binding]; other site
205922012569	substrate binding site [chemical binding]; other site
205922012570	active site
205922012571	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922012572	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
205922012573	Probable Catalytic site; other site
205922012574	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
205922012575	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
205922012576	Mg++ binding site [ion binding]; other site
205922012577	putative catalytic motif [active]
205922012578	putative substrate binding site [chemical binding]; other site
205922012579	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922012580	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
205922012581	putative NAD(P) binding site [chemical binding]; other site
205922012582	active site
205922012583	putative substrate binding site [chemical binding]; other site
205922012584	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922012585	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
205922012586	Probable Catalytic site; other site
205922012587	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
205922012588	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
205922012589	substrate binding site; other site
205922012590	tetramer interface; other site
205922012591	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
205922012592	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
205922012593	NADP binding site [chemical binding]; other site
205922012594	active site
205922012595	putative substrate binding site [chemical binding]; other site
205922012596	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
205922012597	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
205922012598	NAD binding site [chemical binding]; other site
205922012599	substrate binding site [chemical binding]; other site
205922012600	homodimer interface [polypeptide binding]; other site
205922012601	active site
205922012602	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
205922012603	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
205922012604	IHF dimer interface [polypeptide binding]; other site
205922012605	IHF - DNA interface [nucleotide binding]; other site
205922012606	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
205922012607	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
205922012608	inhibitor-cofactor binding pocket; inhibition site
205922012609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012610	catalytic residue [active]
205922012611	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922012612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922012613	Coenzyme A binding pocket [chemical binding]; other site
205922012614	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
205922012615	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
205922012616	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
205922012617	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
205922012618	Walker A/P-loop; other site
205922012619	ATP binding site [chemical binding]; other site
205922012620	Q-loop/lid; other site
205922012621	ABC transporter signature motif; other site
205922012622	Walker B; other site
205922012623	D-loop; other site
205922012624	H-loop/switch region; other site
205922012625	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922012626	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
205922012627	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
205922012628	active site
205922012629	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
205922012630	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
205922012631	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922012632	Methyltransferase domain; Region: Methyltransf_11; pfam08241
205922012633	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922012634	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
205922012635	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
205922012636	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922012637	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
205922012638	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
205922012639	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922012640	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
205922012641	putative NAD(P) binding site [chemical binding]; other site
205922012642	active site
205922012643	putative substrate binding site [chemical binding]; other site
205922012644	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
205922012645	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
205922012646	RNA binding site [nucleotide binding]; other site
205922012647	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
205922012648	RNA binding site [nucleotide binding]; other site
205922012649	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
205922012650	RNA binding site [nucleotide binding]; other site
205922012651	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
205922012652	RNA binding site [nucleotide binding]; other site
205922012653	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
205922012654	RNA binding site [nucleotide binding]; other site
205922012655	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
205922012656	RNA binding site [nucleotide binding]; other site
205922012657	cytidylate kinase; Provisional; Region: cmk; PRK00023
205922012658	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
205922012659	CMP-binding site; other site
205922012660	The sites determining sugar specificity; other site
205922012661	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
205922012662	prephenate dehydrogenase; Validated; Region: PRK08507
205922012663	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
205922012664	hinge; other site
205922012665	active site
205922012666	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
205922012667	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922012668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012669	homodimer interface [polypeptide binding]; other site
205922012670	catalytic residue [active]
205922012671	Chorismate mutase type II; Region: CM_2; cl00693
205922012672	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
205922012673	Prephenate dehydratase; Region: PDT; pfam00800
205922012674	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
205922012675	putative L-Phe binding site [chemical binding]; other site
205922012676	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
205922012677	homodimer interface [polypeptide binding]; other site
205922012678	substrate-cofactor binding pocket; other site
205922012679	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012680	catalytic residue [active]
205922012681	DNA gyrase subunit A; Validated; Region: PRK05560
205922012682	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
205922012683	CAP-like domain; other site
205922012684	active site
205922012685	primary dimer interface [polypeptide binding]; other site
205922012686	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205922012687	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205922012688	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205922012689	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205922012690	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205922012691	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
205922012692	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
205922012693	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
205922012694	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
205922012695	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
205922012696	active site
205922012697	putative substrate binding pocket [chemical binding]; other site
205922012698	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
205922012699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922012700	S-adenosylmethionine binding site [chemical binding]; other site
205922012701	phosphoglycolate phosphatase; Provisional; Region: PRK13222
205922012702	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922012703	motif II; other site
205922012704	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
205922012705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922012706	NAD(P) binding site [chemical binding]; other site
205922012707	active site
205922012708	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922012709	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922012710	metal binding site [ion binding]; metal-binding site
205922012711	active site
205922012712	I-site; other site
205922012713	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
205922012714	PAS domain S-box; Region: sensory_box; TIGR00229
205922012715	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922012716	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922012717	metal binding site [ion binding]; metal-binding site
205922012718	active site
205922012719	I-site; other site
205922012720	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922012721	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
205922012722	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
205922012723	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
205922012724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922012725	Walker A/P-loop; other site
205922012726	ATP binding site [chemical binding]; other site
205922012727	Q-loop/lid; other site
205922012728	ABC transporter signature motif; other site
205922012729	Walker B; other site
205922012730	D-loop; other site
205922012731	H-loop/switch region; other site
205922012732	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
205922012733	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
205922012734	catalytic residues [active]
205922012735	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
205922012736	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
205922012737	active site residue [active]
205922012738	BolA-like protein; Region: BolA; pfam01722
205922012739	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
205922012740	fumarate hydratase; Provisional; Region: PRK12425
205922012741	Class II fumarases; Region: Fumarase_classII; cd01362
205922012742	active site
205922012743	tetramer interface [polypeptide binding]; other site
205922012744	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
205922012745	EamA-like transporter family; Region: EamA; pfam00892
205922012746	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
205922012747	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
205922012748	dimer interface [polypeptide binding]; other site
205922012749	active site
205922012750	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
205922012751	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
205922012752	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
205922012753	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
205922012754	Uncharacterized conserved protein [Function unknown]; Region: COG4121
205922012755	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
205922012756	Leucine-rich repeats; other site
205922012757	Substrate binding site [chemical binding]; other site
205922012758	Leucine rich repeat; Region: LRR_8; pfam13855
205922012759	Leucine rich repeat; Region: LRR_8; pfam13855
205922012760	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
205922012761	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
205922012762	active site
205922012763	dimer interface [polypeptide binding]; other site
205922012764	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
205922012765	Ligand Binding Site [chemical binding]; other site
205922012766	Molecular Tunnel; other site
205922012767	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
205922012768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922012769	Coenzyme A binding pocket [chemical binding]; other site
205922012770	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205922012771	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
205922012772	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
205922012773	putative oligomer interface [polypeptide binding]; other site
205922012774	putative active site [active]
205922012775	metal binding site [ion binding]; metal-binding site
205922012776	hypothetical protein; Provisional; Region: PRK00304
205922012777	Global regulator protein family; Region: CsrA; pfam02599
205922012778	hypothetical protein; Provisional; Region: PRK02237
205922012779	short chain dehydrogenase; Provisional; Region: PRK05650
205922012780	classical (c) SDRs; Region: SDR_c; cd05233
205922012781	NAD(P) binding site [chemical binding]; other site
205922012782	active site
205922012783	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
205922012784	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
205922012785	Sulfatase; Region: Sulfatase; pfam00884
205922012786	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
205922012787	putative lipid binding site [chemical binding]; other site
205922012788	Flagellin N-methylase; Region: FliB; cl00497
205922012789	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922012790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922012791	DNA-binding site [nucleotide binding]; DNA binding site
205922012792	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922012793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012794	homodimer interface [polypeptide binding]; other site
205922012795	catalytic residue [active]
205922012796	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922012797	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922012798	ligand binding site [chemical binding]; other site
205922012799	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
205922012800	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922012801	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922012802	substrate binding pocket [chemical binding]; other site
205922012803	membrane-bound complex binding site; other site
205922012804	hinge residues; other site
205922012805	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
205922012806	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
205922012807	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
205922012808	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
205922012809	Ligand binding site [chemical binding]; other site
205922012810	Electron transfer flavoprotein domain; Region: ETF; pfam01012
205922012811	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
205922012812	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922012813	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
205922012814	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
205922012815	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922012816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922012817	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922012818	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
205922012819	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
205922012820	putative NAD(P) binding site [chemical binding]; other site
205922012821	putative substrate binding site [chemical binding]; other site
205922012822	catalytic Zn binding site [ion binding]; other site
205922012823	structural Zn binding site [ion binding]; other site
205922012824	dimer interface [polypeptide binding]; other site
205922012825	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922012826	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
205922012827	Bacterial transcriptional regulator; Region: IclR; pfam01614
205922012828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922012829	D-galactonate transporter; Region: 2A0114; TIGR00893
205922012830	putative substrate translocation pore; other site
205922012831	galactonate dehydratase; Provisional; Region: PRK14017
205922012832	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
205922012833	putative active site pocket [active]
205922012834	putative metal binding site [ion binding]; other site
205922012835	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
205922012836	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
205922012837	active site
205922012838	intersubunit interface [polypeptide binding]; other site
205922012839	catalytic residue [active]
205922012840	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
205922012841	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
205922012842	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
205922012843	PAAR motif; Region: PAAR_motif; pfam05488
205922012844	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922012845	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922012846	Coenzyme A binding pocket [chemical binding]; other site
205922012847	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
205922012848	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922012849	Zn2+ binding site [ion binding]; other site
205922012850	Mg2+ binding site [ion binding]; other site
205922012851	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
205922012852	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
205922012853	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
205922012854	substrate binding site [chemical binding]; other site
205922012855	ATP binding site [chemical binding]; other site
205922012856	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
205922012857	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
205922012858	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
205922012859	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
205922012860	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922012861	DNA-binding site [nucleotide binding]; DNA binding site
205922012862	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
205922012863	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
205922012864	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
205922012865	TM-ABC transporter signature motif; other site
205922012866	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
205922012867	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
205922012868	Walker A/P-loop; other site
205922012869	ATP binding site [chemical binding]; other site
205922012870	Q-loop/lid; other site
205922012871	ABC transporter signature motif; other site
205922012872	Walker B; other site
205922012873	D-loop; other site
205922012874	H-loop/switch region; other site
205922012875	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
205922012876	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
205922012877	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
205922012878	ligand binding site [chemical binding]; other site
205922012879	short chain dehydrogenase; Provisional; Region: PRK07063
205922012880	classical (c) SDRs; Region: SDR_c; cd05233
205922012881	NAD(P) binding site [chemical binding]; other site
205922012882	active site
205922012883	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
205922012884	Strictosidine synthase; Region: Str_synth; pfam03088
205922012885	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922012886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922012887	DNA-binding site [nucleotide binding]; DNA binding site
205922012888	FCD domain; Region: FCD; pfam07729
205922012889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
205922012890	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
205922012891	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
205922012892	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922012893	FeS/SAM binding site; other site
205922012894	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
205922012895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922012896	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922012897	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
205922012898	active site
205922012899	PilZ domain; Region: PilZ; cl01260
205922012900	DNA polymerase III subunit delta'; Validated; Region: PRK05707
205922012901	DNA polymerase III subunit delta'; Validated; Region: PRK08485
205922012902	thymidylate kinase; Validated; Region: tmk; PRK00698
205922012903	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
205922012904	TMP-binding site; other site
205922012905	ATP-binding site [chemical binding]; other site
205922012906	YceG-like family; Region: YceG; pfam02618
205922012907	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
205922012908	dimerization interface [polypeptide binding]; other site
205922012909	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
205922012910	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
205922012911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922012912	catalytic residue [active]
205922012913	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
205922012914	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205922012915	dimer interface [polypeptide binding]; other site
205922012916	active site
205922012917	acyl carrier protein; Provisional; Region: acpP; PRK00982
205922012918	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
205922012919	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
205922012920	NAD(P) binding site [chemical binding]; other site
205922012921	homotetramer interface [polypeptide binding]; other site
205922012922	homodimer interface [polypeptide binding]; other site
205922012923	active site
205922012924	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
205922012925	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
205922012926	putative phosphate acyltransferase; Provisional; Region: PRK05331
205922012927	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
205922012928	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
205922012929	Maf-like protein; Region: Maf; pfam02545
205922012930	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
205922012931	active site
205922012932	dimer interface [polypeptide binding]; other site
205922012933	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
205922012934	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
205922012935	tandem repeat interface [polypeptide binding]; other site
205922012936	oligomer interface [polypeptide binding]; other site
205922012937	active site residues [active]
205922012938	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
205922012939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922012940	motif II; other site
205922012941	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
205922012942	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922012943	RNA binding surface [nucleotide binding]; other site
205922012944	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
205922012945	active site
205922012946	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
205922012947	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
205922012948	homodimer interface [polypeptide binding]; other site
205922012949	oligonucleotide binding site [chemical binding]; other site
205922012950	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
205922012951	Ligand binding site; other site
205922012952	metal-binding site
205922012953	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
205922012954	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
205922012955	XdhC Rossmann domain; Region: XdhC_C; pfam13478
205922012956	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
205922012957	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922012958	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
205922012959	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922012960	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
205922012961	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
205922012962	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922012963	catalytic loop [active]
205922012964	iron binding site [ion binding]; other site
205922012965	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
205922012966	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
205922012967	FAD binding domain; Region: FAD_binding_4; pfam01565
205922012968	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
205922012969	Low molecular weight phosphatase family; Region: LMWPc; cd00115
205922012970	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
205922012971	active site
205922012972	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
205922012973	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
205922012974	Ligand binding site; other site
205922012975	oligomer interface; other site
205922012976	Uncharacterized conserved protein [Function unknown]; Region: COG2835
205922012977	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
205922012978	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
205922012979	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
205922012980	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
205922012981	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
205922012982	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
205922012983	Competence protein; Region: Competence; pfam03772
205922012984	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
205922012985	inner membrane transport permease; Provisional; Region: PRK15066
205922012986	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
205922012987	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
205922012988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922012989	Walker A/P-loop; other site
205922012990	ATP binding site [chemical binding]; other site
205922012991	Q-loop/lid; other site
205922012992	ABC transporter signature motif; other site
205922012993	Walker B; other site
205922012994	D-loop; other site
205922012995	H-loop/switch region; other site
205922012996	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922012997	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
205922012998	putative C-terminal domain interface [polypeptide binding]; other site
205922012999	putative GSH binding site (G-site) [chemical binding]; other site
205922013000	putative dimer interface [polypeptide binding]; other site
205922013001	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
205922013002	putative N-terminal domain interface [polypeptide binding]; other site
205922013003	putative dimer interface [polypeptide binding]; other site
205922013004	putative substrate binding pocket (H-site) [chemical binding]; other site
205922013005	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
205922013006	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
205922013007	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
205922013008	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
205922013009	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
205922013010	active site
205922013011	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
205922013012	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922013013	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922013014	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922013015	putative effector binding pocket; other site
205922013016	dimerization interface [polypeptide binding]; other site
205922013017	alanine-tRNA ligase; Region: PLN02961
205922013018	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
205922013019	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
205922013020	LysE type translocator; Region: LysE; cl00565
205922013021	hypothetical protein; Provisional; Region: PRK06156
205922013022	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
205922013023	active site
205922013024	metal binding site [ion binding]; metal-binding site
205922013025	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922013026	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013027	dimerization interface [polypeptide binding]; other site
205922013028	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013029	dimer interface [polypeptide binding]; other site
205922013030	putative CheW interface [polypeptide binding]; other site
205922013031	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922013032	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922013033	DNA-binding site [nucleotide binding]; DNA binding site
205922013034	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922013035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013036	homodimer interface [polypeptide binding]; other site
205922013037	catalytic residue [active]
205922013038	short chain dehydrogenase; Provisional; Region: PRK06172
205922013039	classical (c) SDRs; Region: SDR_c; cd05233
205922013040	NAD(P) binding site [chemical binding]; other site
205922013041	active site
205922013042	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
205922013043	Prostaglandin dehydrogenases; Region: PGDH; cd05288
205922013044	NAD(P) binding site [chemical binding]; other site
205922013045	substrate binding site [chemical binding]; other site
205922013046	dimer interface [polypeptide binding]; other site
205922013047	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
205922013048	active site
205922013049	dimer interface [polypeptide binding]; other site
205922013050	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922013051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013052	active site
205922013053	phosphorylation site [posttranslational modification]
205922013054	intermolecular recognition site; other site
205922013055	dimerization interface [polypeptide binding]; other site
205922013056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922013057	DNA binding site [nucleotide binding]
205922013058	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013059	dimerization interface [polypeptide binding]; other site
205922013060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013061	dimer interface [polypeptide binding]; other site
205922013062	phosphorylation site [posttranslational modification]
205922013063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013064	ATP binding site [chemical binding]; other site
205922013065	Mg2+ binding site [ion binding]; other site
205922013066	G-X-G motif; other site
205922013067	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
205922013068	Ca2+ binding site [ion binding]; other site
205922013069	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
205922013070	Domain of unknown function DUF20; Region: UPF0118; pfam01594
205922013071	pyrimidine utilization protein D; Region: RutD; TIGR03611
205922013072	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922013073	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
205922013074	CoenzymeA binding site [chemical binding]; other site
205922013075	subunit interaction site [polypeptide binding]; other site
205922013076	PHB binding site; other site
205922013077	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
205922013078	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
205922013079	acyl-activating enzyme (AAE) consensus motif; other site
205922013080	putative AMP binding site [chemical binding]; other site
205922013081	putative active site [active]
205922013082	putative CoA binding site [chemical binding]; other site
205922013083	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
205922013084	catalytic core [active]
205922013085	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
205922013086	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
205922013087	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
205922013088	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
205922013089	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
205922013090	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
205922013091	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
205922013092	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922013093	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013094	dimerization interface [polypeptide binding]; other site
205922013095	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013096	dimer interface [polypeptide binding]; other site
205922013097	phosphorylation site [posttranslational modification]
205922013098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013099	ATP binding site [chemical binding]; other site
205922013100	Mg2+ binding site [ion binding]; other site
205922013101	G-X-G motif; other site
205922013102	Response regulator receiver domain; Region: Response_reg; pfam00072
205922013103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013104	active site
205922013105	phosphorylation site [posttranslational modification]
205922013106	intermolecular recognition site; other site
205922013107	dimerization interface [polypeptide binding]; other site
205922013108	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
205922013109	active site 1 [active]
205922013110	dimer interface [polypeptide binding]; other site
205922013111	active site 2 [active]
205922013112	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
205922013113	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
205922013114	dimer interface [polypeptide binding]; other site
205922013115	active site
205922013116	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
205922013117	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
205922013118	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
205922013119	homodimer interface [polypeptide binding]; other site
205922013120	metal binding site [ion binding]; metal-binding site
205922013121	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
205922013122	homodimer interface [polypeptide binding]; other site
205922013123	active site
205922013124	putative chemical substrate binding site [chemical binding]; other site
205922013125	metal binding site [ion binding]; metal-binding site
205922013126	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
205922013127	HD domain; Region: HD_4; pfam13328
205922013128	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
205922013129	synthetase active site [active]
205922013130	NTP binding site [chemical binding]; other site
205922013131	metal binding site [ion binding]; metal-binding site
205922013132	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
205922013133	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
205922013134	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
205922013135	TRAM domain; Region: TRAM; pfam01938
205922013136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922013137	S-adenosylmethionine binding site [chemical binding]; other site
205922013138	cysteine synthase B; Region: cysM; TIGR01138
205922013139	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
205922013140	dimer interface [polypeptide binding]; other site
205922013141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013142	catalytic residue [active]
205922013143	CopC domain; Region: CopC; cl01012
205922013144	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922013145	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013146	dimerization interface [polypeptide binding]; other site
205922013147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013148	dimer interface [polypeptide binding]; other site
205922013149	phosphorylation site [posttranslational modification]
205922013150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013151	ATP binding site [chemical binding]; other site
205922013152	Mg2+ binding site [ion binding]; other site
205922013153	G-X-G motif; other site
205922013154	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922013155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013156	active site
205922013157	phosphorylation site [posttranslational modification]
205922013158	intermolecular recognition site; other site
205922013159	dimerization interface [polypeptide binding]; other site
205922013160	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922013161	DNA binding site [nucleotide binding]
205922013162	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
205922013163	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013164	dimerization interface [polypeptide binding]; other site
205922013165	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013166	dimer interface [polypeptide binding]; other site
205922013167	phosphorylation site [posttranslational modification]
205922013168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013169	ATP binding site [chemical binding]; other site
205922013170	Mg2+ binding site [ion binding]; other site
205922013171	G-X-G motif; other site
205922013172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013173	active site
205922013174	phosphorylation site [posttranslational modification]
205922013175	intermolecular recognition site; other site
205922013176	dimerization interface [polypeptide binding]; other site
205922013177	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922013178	putative binding surface; other site
205922013179	active site
205922013180	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
205922013181	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
205922013182	putative ligand binding site [chemical binding]; other site
205922013183	putative NAD binding site [chemical binding]; other site
205922013184	catalytic site [active]
205922013185	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
205922013186	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
205922013187	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205922013188	catalytic residues [active]
205922013189	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
205922013190	ArsC family; Region: ArsC; pfam03960
205922013191	catalytic residues [active]
205922013192	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
205922013193	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922013194	Predicted membrane protein [Function unknown]; Region: COG3308
205922013195	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
205922013196	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
205922013197	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
205922013198	Ligand Binding Site [chemical binding]; other site
205922013199	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
205922013200	hypothetical protein; Provisional; Region: PRK04860
205922013201	SprT homologues; Region: SprT; cl01182
205922013202	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
205922013203	CoA-transferase family III; Region: CoA_transf_3; pfam02515
205922013204	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
205922013205	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922013206	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922013207	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922013208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922013209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
205922013210	dimer interface [polypeptide binding]; other site
205922013211	phosphorylation site [posttranslational modification]
205922013212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013213	ATP binding site [chemical binding]; other site
205922013214	Mg2+ binding site [ion binding]; other site
205922013215	G-X-G motif; other site
205922013216	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
205922013217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013218	active site
205922013219	phosphorylation site [posttranslational modification]
205922013220	intermolecular recognition site; other site
205922013221	dimerization interface [polypeptide binding]; other site
205922013222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922013223	DNA binding site [nucleotide binding]
205922013224	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
205922013225	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
205922013226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922013227	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922013228	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
205922013229	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
205922013230	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013231	dimerization interface [polypeptide binding]; other site
205922013232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013233	dimer interface [polypeptide binding]; other site
205922013234	phosphorylation site [posttranslational modification]
205922013235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013236	ATP binding site [chemical binding]; other site
205922013237	Mg2+ binding site [ion binding]; other site
205922013238	G-X-G motif; other site
205922013239	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
205922013240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013241	active site
205922013242	phosphorylation site [posttranslational modification]
205922013243	intermolecular recognition site; other site
205922013244	dimerization interface [polypeptide binding]; other site
205922013245	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922013246	DNA binding site [nucleotide binding]
205922013247	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
205922013248	ATP cone domain; Region: ATP-cone; pfam03477
205922013249	ATP cone domain; Region: ATP-cone; pfam03477
205922013250	Class I ribonucleotide reductase; Region: RNR_I; cd01679
205922013251	active site
205922013252	dimer interface [polypeptide binding]; other site
205922013253	catalytic residues [active]
205922013254	effector binding site; other site
205922013255	R2 peptide binding site; other site
205922013256	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922013257	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922013258	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922013259	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
205922013260	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
205922013261	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
205922013262	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
205922013263	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
205922013264	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
205922013265	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
205922013266	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
205922013267	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
205922013268	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
205922013269	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
205922013270	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
205922013271	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
205922013272	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
205922013273	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
205922013274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922013275	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
205922013276	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922013277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013278	active site
205922013279	phosphorylation site [posttranslational modification]
205922013280	intermolecular recognition site; other site
205922013281	dimerization interface [polypeptide binding]; other site
205922013282	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
205922013283	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
205922013284	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
205922013285	FlgN protein; Region: FlgN; pfam05130
205922013286	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
205922013287	PilZ domain; Region: PilZ; pfam07238
205922013288	putative MFS family transporter protein; Provisional; Region: PRK03633
205922013289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922013290	putative substrate translocation pore; other site
205922013291	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922013292	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922013293	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922013294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013295	ATP binding site [chemical binding]; other site
205922013296	Mg2+ binding site [ion binding]; other site
205922013297	G-X-G motif; other site
205922013298	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
205922013299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013300	active site
205922013301	phosphorylation site [posttranslational modification]
205922013302	intermolecular recognition site; other site
205922013303	dimerization interface [polypeptide binding]; other site
205922013304	TPR repeat; Region: TPR_11; pfam13414
205922013305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922013306	binding surface
205922013307	TPR motif; other site
205922013308	TPR repeat; Region: TPR_11; pfam13414
205922013309	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
205922013310	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
205922013311	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
205922013312	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922013313	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
205922013314	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922013315	Cytochrome c; Region: Cytochrom_C; pfam00034
205922013316	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922013317	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922013318	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013319	dimerization interface [polypeptide binding]; other site
205922013320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013321	dimer interface [polypeptide binding]; other site
205922013322	putative CheW interface [polypeptide binding]; other site
205922013323	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
205922013324	active site
205922013325	Arc-like DNA binding domain; Region: Arc; pfam03869
205922013326	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
205922013327	MgtE intracellular N domain; Region: MgtE_N; smart00924
205922013328	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
205922013329	Divalent cation transporter; Region: MgtE; pfam01769
205922013330	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
205922013331	carbon storage regulator; Provisional; Region: PRK01712
205922013332	aspartate kinase; Reviewed; Region: PRK06635
205922013333	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
205922013334	putative nucleotide binding site [chemical binding]; other site
205922013335	putative catalytic residues [active]
205922013336	putative Mg ion binding site [ion binding]; other site
205922013337	putative aspartate binding site [chemical binding]; other site
205922013338	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
205922013339	putative allosteric regulatory site; other site
205922013340	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
205922013341	putative allosteric regulatory residue; other site
205922013342	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
205922013343	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
205922013344	motif 1; other site
205922013345	active site
205922013346	motif 2; other site
205922013347	motif 3; other site
205922013348	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
205922013349	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
205922013350	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
205922013351	tetramer interface [polypeptide binding]; other site
205922013352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013353	catalytic residue [active]
205922013354	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
205922013355	active site
205922013356	homopentamer interface [polypeptide binding]; other site
205922013357	dimer interface [polypeptide binding]; other site
205922013358	succinylglutamate desuccinylase; Provisional; Region: PRK05324
205922013359	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
205922013360	active site
205922013361	Zn binding site [ion binding]; other site
205922013362	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
205922013363	succinylarginine dihydrolase; Provisional; Region: PRK13281
205922013364	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
205922013365	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
205922013366	NAD(P) binding site [chemical binding]; other site
205922013367	catalytic residues [active]
205922013368	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
205922013369	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
205922013370	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
205922013371	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
205922013372	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
205922013373	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922013374	inhibitor-cofactor binding pocket; inhibition site
205922013375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013376	catalytic residue [active]
205922013377	Leucine rich repeat; Region: LRR_8; pfam13855
205922013378	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
205922013379	Leucine rich repeat; Region: LRR_8; pfam13855
205922013380	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
205922013381	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
205922013382	Substrate binding site [chemical binding]; other site
205922013383	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
205922013384	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922013385	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
205922013386	conserved cys residue [active]
205922013387	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922013388	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922013389	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
205922013390	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922013391	Walker A/P-loop; other site
205922013392	ATP binding site [chemical binding]; other site
205922013393	Q-loop/lid; other site
205922013394	ABC transporter signature motif; other site
205922013395	Walker B; other site
205922013396	D-loop; other site
205922013397	H-loop/switch region; other site
205922013398	Predicted deacylase [General function prediction only]; Region: COG3608
205922013399	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
205922013400	active site
205922013401	Zn binding site [ion binding]; other site
205922013402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922013403	dimer interface [polypeptide binding]; other site
205922013404	conserved gate region; other site
205922013405	putative PBP binding loops; other site
205922013406	ABC-ATPase subunit interface; other site
205922013407	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922013408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922013409	dimer interface [polypeptide binding]; other site
205922013410	conserved gate region; other site
205922013411	putative PBP binding loops; other site
205922013412	ABC-ATPase subunit interface; other site
205922013413	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
205922013414	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922013415	substrate binding pocket [chemical binding]; other site
205922013416	membrane-bound complex binding site; other site
205922013417	hinge residues; other site
205922013418	acetyl-CoA synthetase; Provisional; Region: PRK00174
205922013419	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
205922013420	active site
205922013421	CoA binding site [chemical binding]; other site
205922013422	acyl-activating enzyme (AAE) consensus motif; other site
205922013423	AMP binding site [chemical binding]; other site
205922013424	acetate binding site [chemical binding]; other site
205922013425	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922013426	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
205922013427	dimer interface [polypeptide binding]; other site
205922013428	putative radical transfer pathway; other site
205922013429	diiron center [ion binding]; other site
205922013430	tyrosyl radical; other site
205922013431	BRO family, N-terminal domain; Region: Bro-N; smart01040
205922013432	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205922013433	active site
205922013434	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922013435	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922013436	Helix-turn-helix domain; Region: HTH_18; pfam12833
205922013437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922013438	Helix-turn-helix domain; Region: HTH_37; pfam13744
205922013439	non-specific DNA binding site [nucleotide binding]; other site
205922013440	salt bridge; other site
205922013441	sequence-specific DNA binding site [nucleotide binding]; other site
205922013442	amidase; Provisional; Region: PRK08137
205922013443	Amidase; Region: Amidase; cl11426
205922013444	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
205922013445	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
205922013446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922013447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922013448	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
205922013449	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
205922013450	MASE2 domain; Region: MASE2; pfam05230
205922013451	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922013452	metal binding site [ion binding]; metal-binding site
205922013453	active site
205922013454	I-site; other site
205922013455	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922013456	PAS domain; Region: PAS_9; pfam13426
205922013457	putative active site [active]
205922013458	heme pocket [chemical binding]; other site
205922013459	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922013460	PAS domain; Region: PAS_9; pfam13426
205922013461	putative active site [active]
205922013462	heme pocket [chemical binding]; other site
205922013463	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013464	dimer interface [polypeptide binding]; other site
205922013465	putative CheW interface [polypeptide binding]; other site
205922013466	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
205922013467	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922013468	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922013469	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922013470	dimerization interface [polypeptide binding]; other site
205922013471	hypothetical protein; Validated; Region: PRK06186
205922013472	conserved cys residue [active]
205922013473	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
205922013474	Protein of unknown function (DUF2025); Region: DUF2025; pfam09634
205922013475	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
205922013476	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
205922013477	active site
205922013478	catalytic site [active]
205922013479	metal binding site [ion binding]; metal-binding site
205922013480	Predicted membrane protein [Function unknown]; Region: COG3212
205922013481	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
205922013482	HAMP domain; Region: HAMP; pfam00672
205922013483	dimerization interface [polypeptide binding]; other site
205922013484	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922013485	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013486	dimer interface [polypeptide binding]; other site
205922013487	putative CheW interface [polypeptide binding]; other site
205922013488	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
205922013489	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
205922013490	Cl binding site [ion binding]; other site
205922013491	oligomer interface [polypeptide binding]; other site
205922013492	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
205922013493	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
205922013494	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922013495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922013496	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
205922013497	putative effector binding pocket; other site
205922013498	putative dimerization interface [polypeptide binding]; other site
205922013499	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
205922013500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922013501	NAD(P) binding site [chemical binding]; other site
205922013502	active site
205922013503	Predicted membrane protein [Function unknown]; Region: COG4125
205922013504	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
205922013505	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
205922013506	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922013507	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922013508	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922013509	dimerization interface [polypeptide binding]; other site
205922013510	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922013511	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922013512	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922013513	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
205922013514	classical (c) SDRs; Region: SDR_c; cd05233
205922013515	NAD(P) binding site [chemical binding]; other site
205922013516	active site
205922013517	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
205922013518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922013519	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
205922013520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
205922013521	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
205922013522	SnoaL-like domain; Region: SnoaL_3; pfam13474
205922013523	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
205922013524	Coenzyme A binding pocket [chemical binding]; other site
205922013525	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
205922013526	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922013527	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922013528	Coenzyme A binding pocket [chemical binding]; other site
205922013529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
205922013530	LysE type translocator; Region: LysE; cl00565
205922013531	aminotransferase; Validated; Region: PRK08175
205922013532	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922013533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013534	homodimer interface [polypeptide binding]; other site
205922013535	catalytic residue [active]
205922013536	fructuronate transporter; Provisional; Region: PRK10034; cl15264
205922013537	GntP family permease; Region: GntP_permease; pfam02447
205922013538	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
205922013539	AAA domain; Region: AAA_33; pfam13671
205922013540	ATP-binding site [chemical binding]; other site
205922013541	Gluconate-6-phosphate binding site [chemical binding]; other site
205922013542	Transcriptional regulators [Transcription]; Region: PurR; COG1609
205922013543	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
205922013544	DNA binding site [nucleotide binding]
205922013545	domain linker motif; other site
205922013546	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
205922013547	putative ligand binding site [chemical binding]; other site
205922013548	putative dimerization interface [polypeptide binding]; other site
205922013549	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922013550	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922013551	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922013552	dimerization interface [polypeptide binding]; other site
205922013553	Predicted membrane protein [Function unknown]; Region: COG4125
205922013554	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
205922013555	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
205922013556	benzoate transport; Region: 2A0115; TIGR00895
205922013557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922013558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922013559	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
205922013560	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922013561	PAS domain; Region: PAS_9; pfam13426
205922013562	putative active site [active]
205922013563	heme pocket [chemical binding]; other site
205922013564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922013565	PAS domain; Region: PAS_9; pfam13426
205922013566	putative active site [active]
205922013567	heme pocket [chemical binding]; other site
205922013568	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013569	dimer interface [polypeptide binding]; other site
205922013570	putative CheW interface [polypeptide binding]; other site
205922013571	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922013572	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
205922013573	RNA polymerase sigma factor; Provisional; Region: PRK12525
205922013574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922013575	DNA binding residues [nucleotide binding]
205922013576	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
205922013577	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
205922013578	putative di-iron ligands [ion binding]; other site
205922013579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922013580	Coenzyme A binding pocket [chemical binding]; other site
205922013581	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
205922013582	active site
205922013583	catalytic residues [active]
205922013584	metal binding site [ion binding]; metal-binding site
205922013585	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
205922013586	CsbD-like; Region: CsbD; pfam05532
205922013587	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
205922013588	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
205922013589	acyl-activating enzyme (AAE) consensus motif; other site
205922013590	putative AMP binding site [chemical binding]; other site
205922013591	putative active site [active]
205922013592	putative CoA binding site [chemical binding]; other site
205922013593	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
205922013594	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
205922013595	acyl-activating enzyme (AAE) consensus motif; other site
205922013596	putative AMP binding site [chemical binding]; other site
205922013597	putative active site [active]
205922013598	putative CoA binding site [chemical binding]; other site
205922013599	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
205922013600	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922013601	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922013602	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
205922013603	dimer interaction site [polypeptide binding]; other site
205922013604	substrate-binding tunnel; other site
205922013605	active site
205922013606	catalytic site [active]
205922013607	substrate binding site [chemical binding]; other site
205922013608	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
205922013609	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
205922013610	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
205922013611	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
205922013612	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922013613	catalytic residue [active]
205922013614	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
205922013615	putative active site [active]
205922013616	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
205922013617	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
205922013618	active site
205922013619	intersubunit interface [polypeptide binding]; other site
205922013620	catalytic residue [active]
205922013621	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
205922013622	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
205922013623	putative active site [active]
205922013624	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
205922013625	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
205922013626	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
205922013627	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
205922013628	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
205922013629	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
205922013630	putative active site [active]
205922013631	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
205922013632	active site
205922013633	phosphate binding residues; other site
205922013634	catalytic residues [active]
205922013635	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
205922013636	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
205922013637	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
205922013638	Walker A/P-loop; other site
205922013639	ATP binding site [chemical binding]; other site
205922013640	Q-loop/lid; other site
205922013641	ABC transporter signature motif; other site
205922013642	Walker B; other site
205922013643	D-loop; other site
205922013644	H-loop/switch region; other site
205922013645	TOBE domain; Region: TOBE; pfam03459
205922013646	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
205922013647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922013648	dimer interface [polypeptide binding]; other site
205922013649	conserved gate region; other site
205922013650	putative PBP binding loops; other site
205922013651	ABC-ATPase subunit interface; other site
205922013652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922013653	dimer interface [polypeptide binding]; other site
205922013654	conserved gate region; other site
205922013655	putative PBP binding loops; other site
205922013656	ABC-ATPase subunit interface; other site
205922013657	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
205922013658	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
205922013659	dimerization interface [polypeptide binding]; other site
205922013660	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
205922013661	putative active cleft [active]
205922013662	HAMP domain; Region: HAMP; pfam00672
205922013663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013664	ATP binding site [chemical binding]; other site
205922013665	Mg2+ binding site [ion binding]; other site
205922013666	G-X-G motif; other site
205922013667	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922013668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013669	active site
205922013670	phosphorylation site [posttranslational modification]
205922013671	intermolecular recognition site; other site
205922013672	dimerization interface [polypeptide binding]; other site
205922013673	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922013674	DNA binding site [nucleotide binding]
205922013675	glucokinase; Provisional; Region: glk; PRK00292
205922013676	glucokinase, proteobacterial type; Region: glk; TIGR00749
205922013677	phosphogluconate dehydratase; Validated; Region: PRK09054
205922013678	6-phosphogluconate dehydratase; Region: edd; TIGR01196
205922013679	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
205922013680	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
205922013681	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
205922013682	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
205922013683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922013684	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922013685	DNA binding residues [nucleotide binding]
205922013686	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922013687	FecR protein; Region: FecR; pfam04773
205922013688	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922013689	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
205922013690	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922013691	N-terminal plug; other site
205922013692	ligand-binding site [chemical binding]; other site
205922013693	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
205922013694	heme binding pocket [chemical binding]; other site
205922013695	heme ligand [chemical binding]; other site
205922013696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
205922013697	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013698	dimerization interface [polypeptide binding]; other site
205922013699	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922013700	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013701	dimer interface [polypeptide binding]; other site
205922013702	putative CheW interface [polypeptide binding]; other site
205922013703	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
205922013704	CoA-transferase family III; Region: CoA_transf_3; pfam02515
205922013705	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
205922013706	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
205922013707	arginine deiminase; Provisional; Region: PRK01388
205922013708	ornithine carbamoyltransferase; Validated; Region: PRK02102
205922013709	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
205922013710	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
205922013711	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
205922013712	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
205922013713	putative substrate binding site [chemical binding]; other site
205922013714	nucleotide binding site [chemical binding]; other site
205922013715	nucleotide binding site [chemical binding]; other site
205922013716	homodimer interface [polypeptide binding]; other site
205922013717	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
205922013718	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
205922013719	putative aromatic amino acid binding site; other site
205922013720	PAS domain; Region: PAS; smart00091
205922013721	putative active site [active]
205922013722	heme pocket [chemical binding]; other site
205922013723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922013724	Walker A motif; other site
205922013725	ATP binding site [chemical binding]; other site
205922013726	Walker B motif; other site
205922013727	arginine finger; other site
205922013728	glycine cleavage system protein H; Provisional; Region: PRK13380
205922013729	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
205922013730	lipoyl attachment site [posttranslational modification]; other site
205922013731	glycine dehydrogenase; Provisional; Region: PRK05367
205922013732	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
205922013733	tetramer interface [polypeptide binding]; other site
205922013734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013735	catalytic residue [active]
205922013736	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
205922013737	tetramer interface [polypeptide binding]; other site
205922013738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922013739	catalytic residue [active]
205922013740	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
205922013741	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
205922013742	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
205922013743	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
205922013744	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
205922013745	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205922013746	DNA-binding site [nucleotide binding]; DNA binding site
205922013747	RNA-binding motif; other site
205922013748	RDD family; Region: RDD; pfam06271
205922013749	quinolinate synthetase; Provisional; Region: PRK09375
205922013750	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
205922013751	Ligand Binding Site [chemical binding]; other site
205922013752	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
205922013753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922013754	FeS/SAM binding site; other site
205922013755	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
205922013756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
205922013757	binding surface
205922013758	TPR motif; other site
205922013759	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922013760	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922013761	ligand binding site [chemical binding]; other site
205922013762	translocation protein TolB; Provisional; Region: tolB; PRK00178
205922013763	TolB amino-terminal domain; Region: TolB_N; pfam04052
205922013764	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
205922013765	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
205922013766	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
205922013767	TolA protein; Region: tolA_full; TIGR02794
205922013768	TolA protein; Region: tolA_full; TIGR02794
205922013769	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
205922013770	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
205922013771	TolR protein; Region: tolR; TIGR02801
205922013772	TolQ protein; Region: tolQ; TIGR02796
205922013773	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
205922013774	active site
205922013775	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
205922013776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922013777	Walker A motif; other site
205922013778	ATP binding site [chemical binding]; other site
205922013779	Walker B motif; other site
205922013780	arginine finger; other site
205922013781	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
205922013782	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
205922013783	RuvA N terminal domain; Region: RuvA_N; pfam01330
205922013784	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
205922013785	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
205922013786	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
205922013787	active site
205922013788	putative DNA-binding cleft [nucleotide binding]; other site
205922013789	dimer interface [polypeptide binding]; other site
205922013790	hypothetical protein; Validated; Region: PRK00110
205922013791	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
205922013792	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
205922013793	dimer interface [polypeptide binding]; other site
205922013794	anticodon binding site; other site
205922013795	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
205922013796	homodimer interface [polypeptide binding]; other site
205922013797	motif 1; other site
205922013798	active site
205922013799	motif 2; other site
205922013800	GAD domain; Region: GAD; pfam02938
205922013801	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
205922013802	active site
205922013803	motif 3; other site
205922013804	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
205922013805	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
205922013806	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
205922013807	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
205922013808	dimerization interface [polypeptide binding]; other site
205922013809	DPS ferroxidase diiron center [ion binding]; other site
205922013810	ion pore; other site
205922013811	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
205922013812	DNA-binding site [nucleotide binding]; DNA binding site
205922013813	RNA-binding motif; other site
205922013814	hypothetical protein; Provisional; Region: PRK00295
205922013815	HIT domain; Region: HIT; pfam01230
205922013816	outer membrane porin, OprD family; Region: OprD; pfam03573
205922013817	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922013818	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922013819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
205922013820	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
205922013821	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
205922013822	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
205922013823	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
205922013824	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013825	dimerization interface [polypeptide binding]; other site
205922013826	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
205922013827	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922013828	putative active site [active]
205922013829	heme pocket [chemical binding]; other site
205922013830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013831	dimer interface [polypeptide binding]; other site
205922013832	phosphorylation site [posttranslational modification]
205922013833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013834	ATP binding site [chemical binding]; other site
205922013835	Mg2+ binding site [ion binding]; other site
205922013836	G-X-G motif; other site
205922013837	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
205922013838	hypothetical protein; Provisional; Region: PRK08999
205922013839	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
205922013840	active site
205922013841	8-oxo-dGMP binding site [chemical binding]; other site
205922013842	nudix motif; other site
205922013843	metal binding site [ion binding]; metal-binding site
205922013844	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
205922013845	thiamine phosphate binding site [chemical binding]; other site
205922013846	active site
205922013847	pyrophosphate binding site [ion binding]; other site
205922013848	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
205922013849	putative C-terminal domain interface [polypeptide binding]; other site
205922013850	putative GSH binding site (G-site) [chemical binding]; other site
205922013851	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922013852	putative dimer interface [polypeptide binding]; other site
205922013853	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
205922013854	putative substrate binding pocket (H-site) [chemical binding]; other site
205922013855	putative N-terminal domain interface [polypeptide binding]; other site
205922013856	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
205922013857	heterotetramer interface [polypeptide binding]; other site
205922013858	active site pocket [active]
205922013859	cleavage site
205922013860	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
205922013861	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
205922013862	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
205922013863	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
205922013864	nucleotide binding region [chemical binding]; other site
205922013865	ATP-binding site [chemical binding]; other site
205922013866	SEC-C motif; Region: SEC-C; pfam02810
205922013867	Protein of unknown function (DUF721); Region: DUF721; pfam05258
205922013868	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
205922013869	Cache domain; Region: Cache_1; pfam02743
205922013870	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922013871	dimerization interface [polypeptide binding]; other site
205922013872	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922013873	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922013874	dimer interface [polypeptide binding]; other site
205922013875	putative CheW interface [polypeptide binding]; other site
205922013876	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922013877	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
205922013878	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
205922013879	Predicted deacetylase [General function prediction only]; Region: COG3233
205922013880	putative active site [active]
205922013881	putative Zn binding site [ion binding]; other site
205922013882	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
205922013883	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
205922013884	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
205922013885	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
205922013886	putative active site [active]
205922013887	putative substrate binding site [chemical binding]; other site
205922013888	putative cosubstrate binding site; other site
205922013889	catalytic site [active]
205922013890	exonuclease I; Provisional; Region: sbcB; PRK11779
205922013891	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
205922013892	active site
205922013893	catalytic site [active]
205922013894	substrate binding site [chemical binding]; other site
205922013895	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
205922013896	Predicted membrane protein/domain [Function unknown]; Region: COG1714
205922013897	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
205922013898	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
205922013899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922013900	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
205922013901	Walker A motif; other site
205922013902	ATP binding site [chemical binding]; other site
205922013903	Walker B motif; other site
205922013904	arginine finger; other site
205922013905	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
205922013906	Protein of unknown function DUF58; Region: DUF58; pfam01882
205922013907	von Willebrand factor type A domain; Region: VWA_2; pfam13519
205922013908	metal ion-dependent adhesion site (MIDAS); other site
205922013909	PilZ domain; Region: PilZ; pfam07238
205922013910	pyruvate kinase; Provisional; Region: PRK05826
205922013911	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
205922013912	domain interfaces; other site
205922013913	active site
205922013914	enoyl-CoA hydratase; Provisional; Region: PRK06688
205922013915	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
205922013916	substrate binding site [chemical binding]; other site
205922013917	oxyanion hole (OAH) forming residues; other site
205922013918	trimer interface [polypeptide binding]; other site
205922013919	hypothetical protein; Provisional; Region: PRK05713
205922013920	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922013921	catalytic loop [active]
205922013922	iron binding site [ion binding]; other site
205922013923	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
205922013924	FAD binding pocket [chemical binding]; other site
205922013925	FAD binding motif [chemical binding]; other site
205922013926	phosphate binding motif [ion binding]; other site
205922013927	beta-alpha-beta structure motif; other site
205922013928	NAD binding pocket [chemical binding]; other site
205922013929	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922013930	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922013931	metal binding site [ion binding]; metal-binding site
205922013932	active site
205922013933	I-site; other site
205922013934	putative fumarate hydratase; Provisional; Region: PRK15392
205922013935	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
205922013936	Fumarase C-terminus; Region: Fumerase_C; pfam05683
205922013937	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
205922013938	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
205922013939	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
205922013940	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922013941	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922013942	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922013943	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922013944	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
205922013945	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
205922013946	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
205922013947	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
205922013948	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922013949	dimer interface [polypeptide binding]; other site
205922013950	phosphorylation site [posttranslational modification]
205922013951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922013952	ATP binding site [chemical binding]; other site
205922013953	Mg2+ binding site [ion binding]; other site
205922013954	G-X-G motif; other site
205922013955	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922013956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922013957	active site
205922013958	phosphorylation site [posttranslational modification]
205922013959	intermolecular recognition site; other site
205922013960	dimerization interface [polypeptide binding]; other site
205922013961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922013962	Walker A motif; other site
205922013963	ATP binding site [chemical binding]; other site
205922013964	Walker B motif; other site
205922013965	arginine finger; other site
205922013966	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
205922013967	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
205922013968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922013969	putative substrate translocation pore; other site
205922013970	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
205922013971	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
205922013972	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
205922013973	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
205922013974	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
205922013975	Uncharacterized conserved protein [Function unknown]; Region: COG1359
205922013976	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
205922013977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922013978	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922013979	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922013980	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922013981	Walker A/P-loop; other site
205922013982	ATP binding site [chemical binding]; other site
205922013983	Q-loop/lid; other site
205922013984	ABC transporter signature motif; other site
205922013985	Walker B; other site
205922013986	D-loop; other site
205922013987	H-loop/switch region; other site
205922013988	TOBE domain; Region: TOBE_2; pfam08402
205922013989	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922013990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922013991	dimer interface [polypeptide binding]; other site
205922013992	conserved gate region; other site
205922013993	putative PBP binding loops; other site
205922013994	ABC-ATPase subunit interface; other site
205922013995	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
205922013996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922013997	dimer interface [polypeptide binding]; other site
205922013998	putative PBP binding loops; other site
205922013999	ABC-ATPase subunit interface; other site
205922014000	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
205922014001	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922014002	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922014003	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
205922014004	NAD(P) binding site [chemical binding]; other site
205922014005	catalytic residues [active]
205922014006	catalytic residues [active]
205922014007	hypothetical protein; Provisional; Region: PRK07524
205922014008	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
205922014009	PYR/PP interface [polypeptide binding]; other site
205922014010	dimer interface [polypeptide binding]; other site
205922014011	TPP binding site [chemical binding]; other site
205922014012	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
205922014013	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
205922014014	TPP-binding site [chemical binding]; other site
205922014015	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922014016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922014017	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922014018	dimerization interface [polypeptide binding]; other site
205922014019	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
205922014020	NADH(P)-binding; Region: NAD_binding_10; pfam13460
205922014021	NAD binding site [chemical binding]; other site
205922014022	putative active site [active]
205922014023	substrate binding site [chemical binding]; other site
205922014024	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
205922014025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922014026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922014027	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922014028	putative effector binding pocket; other site
205922014029	dimerization interface [polypeptide binding]; other site
205922014030	Cupin domain; Region: Cupin_2; cl17218
205922014031	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922014032	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922014033	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
205922014034	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
205922014035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922014036	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922014037	putative substrate translocation pore; other site
205922014038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922014039	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
205922014040	Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506
205922014041	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922014042	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922014043	NAD(P) binding site [chemical binding]; other site
205922014044	active site
205922014045	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
205922014046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922014047	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922014048	dimerization interface [polypeptide binding]; other site
205922014049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
205922014050	ACT domain; Region: ACT_3; pfam10000
205922014051	Family description; Region: ACT_7; pfam13840
205922014052	Lysine efflux permease [General function prediction only]; Region: COG1279
205922014053	superoxide dismutase; Provisional; Region: PRK10543
205922014054	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
205922014055	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
205922014056	biofilm formation regulator HmsP; Provisional; Region: PRK11829
205922014057	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922014058	metal binding site [ion binding]; metal-binding site
205922014059	active site
205922014060	I-site; other site
205922014061	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922014062	Imelysin; Region: Peptidase_M75; cl09159
205922014063	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
205922014064	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
205922014065	Imelysin; Region: Peptidase_M75; cl09159
205922014066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
205922014067	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922014068	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922014069	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922014070	multidrug efflux protein; Reviewed; Region: PRK09579
205922014071	Protein export membrane protein; Region: SecD_SecF; cl14618
205922014072	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
205922014073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922014074	S-adenosylmethionine binding site [chemical binding]; other site
205922014075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922014076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922014077	dimer interface [polypeptide binding]; other site
205922014078	phosphorylation site [posttranslational modification]
205922014079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922014080	ATP binding site [chemical binding]; other site
205922014081	Mg2+ binding site [ion binding]; other site
205922014082	G-X-G motif; other site
205922014083	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922014084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014085	active site
205922014086	phosphorylation site [posttranslational modification]
205922014087	intermolecular recognition site; other site
205922014088	dimerization interface [polypeptide binding]; other site
205922014089	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922014090	DNA binding site [nucleotide binding]
205922014091	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
205922014092	Sulfatase; Region: Sulfatase; pfam00884
205922014093	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
205922014094	active site
205922014095	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
205922014096	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
205922014097	ring oligomerisation interface [polypeptide binding]; other site
205922014098	ATP/Mg binding site [chemical binding]; other site
205922014099	stacking interactions; other site
205922014100	hinge regions; other site
205922014101	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
205922014102	oligomerisation interface [polypeptide binding]; other site
205922014103	mobile loop; other site
205922014104	roof hairpin; other site
205922014105	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
205922014106	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
205922014107	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
205922014108	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
205922014109	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
205922014110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922014111	NAD(P) binding site [chemical binding]; other site
205922014112	active site
205922014113	antiporter inner membrane protein; Provisional; Region: PRK11670
205922014114	Domain of unknown function DUF59; Region: DUF59; pfam01883
205922014115	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
205922014116	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
205922014117	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
205922014118	active site
205922014119	HIGH motif; other site
205922014120	KMSKS motif; other site
205922014121	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
205922014122	tRNA binding surface [nucleotide binding]; other site
205922014123	anticodon binding site; other site
205922014124	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
205922014125	dimer interface [polypeptide binding]; other site
205922014126	putative tRNA-binding site [nucleotide binding]; other site
205922014127	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
205922014128	ferredoxin; Provisional; Region: PRK08764
205922014129	Putative Fe-S cluster; Region: FeS; pfam04060
205922014130	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
205922014131	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
205922014132	electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947
205922014133	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
205922014134	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
205922014135	minor groove reading motif; other site
205922014136	helix-hairpin-helix signature motif; other site
205922014137	substrate binding pocket [chemical binding]; other site
205922014138	active site
205922014139	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
205922014140	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922014141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014142	active site
205922014143	phosphorylation site [posttranslational modification]
205922014144	intermolecular recognition site; other site
205922014145	dimerization interface [polypeptide binding]; other site
205922014146	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922014147	DNA binding residues [nucleotide binding]
205922014148	dimerization interface [polypeptide binding]; other site
205922014149	argininosuccinate synthase; Provisional; Region: PRK13820
205922014150	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
205922014151	ANP binding site [chemical binding]; other site
205922014152	Substrate Binding Site II [chemical binding]; other site
205922014153	Substrate Binding Site I [chemical binding]; other site
205922014154	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922014155	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922014156	ligand binding site [chemical binding]; other site
205922014157	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
205922014158	active site
205922014159	substrate binding pocket [chemical binding]; other site
205922014160	dimer interface [polypeptide binding]; other site
205922014161	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
205922014162	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
205922014163	dimer interface [polypeptide binding]; other site
205922014164	catalytic site [active]
205922014165	putative active site [active]
205922014166	putative substrate binding site [chemical binding]; other site
205922014167	peroxidase; Provisional; Region: PRK15000
205922014168	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
205922014169	dimer interface [polypeptide binding]; other site
205922014170	decamer (pentamer of dimers) interface [polypeptide binding]; other site
205922014171	catalytic triad [active]
205922014172	peroxidatic and resolving cysteines [active]
205922014173	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
205922014174	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
205922014175	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
205922014176	heme binding site [chemical binding]; other site
205922014177	ferroxidase pore; other site
205922014178	ferroxidase diiron center [ion binding]; other site
205922014179	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
205922014180	putative GSH binding site [chemical binding]; other site
205922014181	catalytic residues [active]
205922014182	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
205922014183	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
205922014184	putative [Fe4-S4] binding site [ion binding]; other site
205922014185	putative molybdopterin cofactor binding site [chemical binding]; other site
205922014186	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
205922014187	putative molybdopterin cofactor binding site; other site
205922014188	ornithine carbamoyltransferase; Provisional; Region: PRK00779
205922014189	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
205922014190	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
205922014191	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922014192	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
205922014193	Walker A/P-loop; other site
205922014194	ATP binding site [chemical binding]; other site
205922014195	Q-loop/lid; other site
205922014196	ABC transporter signature motif; other site
205922014197	Walker B; other site
205922014198	D-loop; other site
205922014199	H-loop/switch region; other site
205922014200	TOBE domain; Region: TOBE_2; pfam08402
205922014201	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
205922014202	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
205922014203	putative deacylase active site [active]
205922014204	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
205922014205	amphipathic channel; other site
205922014206	Asn-Pro-Ala signature motifs; other site
205922014207	glycerol kinase; Provisional; Region: glpK; PRK00047
205922014208	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
205922014209	N- and C-terminal domain interface [polypeptide binding]; other site
205922014210	active site
205922014211	MgATP binding site [chemical binding]; other site
205922014212	catalytic site [active]
205922014213	metal binding site [ion binding]; metal-binding site
205922014214	glycerol binding site [chemical binding]; other site
205922014215	homotetramer interface [polypeptide binding]; other site
205922014216	homodimer interface [polypeptide binding]; other site
205922014217	protein IIAGlc interface [polypeptide binding]; other site
205922014218	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
205922014219	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
205922014220	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
205922014221	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
205922014222	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
205922014223	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922014224	substrate binding pocket [chemical binding]; other site
205922014225	membrane-bound complex binding site; other site
205922014226	hinge residues; other site
205922014227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922014228	dimer interface [polypeptide binding]; other site
205922014229	conserved gate region; other site
205922014230	putative PBP binding loops; other site
205922014231	ABC-ATPase subunit interface; other site
205922014232	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922014233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922014234	dimer interface [polypeptide binding]; other site
205922014235	conserved gate region; other site
205922014236	putative PBP binding loops; other site
205922014237	ABC-ATPase subunit interface; other site
205922014238	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922014239	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922014240	Walker A/P-loop; other site
205922014241	ATP binding site [chemical binding]; other site
205922014242	Q-loop/lid; other site
205922014243	ABC transporter signature motif; other site
205922014244	Walker B; other site
205922014245	D-loop; other site
205922014246	H-loop/switch region; other site
205922014247	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
205922014248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922014249	dimer interface [polypeptide binding]; other site
205922014250	phosphorylation site [posttranslational modification]
205922014251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922014252	ATP binding site [chemical binding]; other site
205922014253	Mg2+ binding site [ion binding]; other site
205922014254	G-X-G motif; other site
205922014255	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922014256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014257	active site
205922014258	phosphorylation site [posttranslational modification]
205922014259	intermolecular recognition site; other site
205922014260	dimerization interface [polypeptide binding]; other site
205922014261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922014262	Walker A motif; other site
205922014263	ATP binding site [chemical binding]; other site
205922014264	Walker B motif; other site
205922014265	arginine finger; other site
205922014266	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922014267	GlpM protein; Region: GlpM; pfam06942
205922014268	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922014269	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
205922014270	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
205922014271	THF binding site; other site
205922014272	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
205922014273	substrate binding site [chemical binding]; other site
205922014274	THF binding site; other site
205922014275	zinc-binding site [ion binding]; other site
205922014276	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
205922014277	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922014278	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
205922014279	putative dimerization interface [polypeptide binding]; other site
205922014280	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922014281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922014282	Coenzyme A binding pocket [chemical binding]; other site
205922014283	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922014284	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
205922014285	nudix motif; other site
205922014286	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
205922014287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014288	active site
205922014289	phosphorylation site [posttranslational modification]
205922014290	intermolecular recognition site; other site
205922014291	dimerization interface [polypeptide binding]; other site
205922014292	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922014293	Zn2+ binding site [ion binding]; other site
205922014294	Mg2+ binding site [ion binding]; other site
205922014295	Response regulator receiver domain; Region: Response_reg; pfam00072
205922014296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014297	active site
205922014298	phosphorylation site [posttranslational modification]
205922014299	intermolecular recognition site; other site
205922014300	dimerization interface [polypeptide binding]; other site
205922014301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922014302	PAS fold; Region: PAS_3; pfam08447
205922014303	putative active site [active]
205922014304	heme pocket [chemical binding]; other site
205922014305	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922014306	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922014307	metal binding site [ion binding]; metal-binding site
205922014308	active site
205922014309	I-site; other site
205922014310	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922014311	Response regulator receiver domain; Region: Response_reg; pfam00072
205922014312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014313	active site
205922014314	phosphorylation site [posttranslational modification]
205922014315	intermolecular recognition site; other site
205922014316	dimerization interface [polypeptide binding]; other site
205922014317	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922014318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922014319	metal binding site [ion binding]; metal-binding site
205922014320	active site
205922014321	I-site; other site
205922014322	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922014323	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
205922014324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922014325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922014326	ATP binding site [chemical binding]; other site
205922014327	G-X-G motif; other site
205922014328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014329	active site
205922014330	phosphorylation site [posttranslational modification]
205922014331	intermolecular recognition site; other site
205922014332	dimerization interface [polypeptide binding]; other site
205922014333	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
205922014334	dimer interface [polypeptide binding]; other site
205922014335	phosphorylation site [posttranslational modification]
205922014336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922014337	ATP binding site [chemical binding]; other site
205922014338	Mg2+ binding site [ion binding]; other site
205922014339	G-X-G motif; other site
205922014340	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
205922014341	Predicted amidohydrolase [General function prediction only]; Region: COG0388
205922014342	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
205922014343	putative active site [active]
205922014344	catalytic triad [active]
205922014345	putative dimer interface [polypeptide binding]; other site
205922014346	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922014347	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922014348	DNA binding residues [nucleotide binding]
205922014349	dimerization interface [polypeptide binding]; other site
205922014350	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
205922014351	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
205922014352	active site
205922014353	FMN binding site [chemical binding]; other site
205922014354	substrate binding site [chemical binding]; other site
205922014355	3Fe-4S cluster binding site [ion binding]; other site
205922014356	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
205922014357	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
205922014358	Spore germination protein; Region: Spore_permease; cl17796
205922014359	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
205922014360	Transglycosylase; Region: Transgly; cl17702
205922014361	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
205922014362	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
205922014363	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
205922014364	CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524
205922014365	putative fimbrial protein TcfA; Provisional; Region: PRK15308
205922014366	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
205922014367	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
205922014368	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
205922014369	Predicted transcriptional regulators [Transcription]; Region: COG1695
205922014370	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
205922014371	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
205922014372	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
205922014373	FAD binding pocket [chemical binding]; other site
205922014374	FAD binding motif [chemical binding]; other site
205922014375	phosphate binding motif [ion binding]; other site
205922014376	NAD binding pocket [chemical binding]; other site
205922014377	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
205922014378	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
205922014379	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
205922014380	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
205922014381	Trp docking motif [polypeptide binding]; other site
205922014382	putative active site [active]
205922014383	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
205922014384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922014385	Walker A motif; other site
205922014386	ATP binding site [chemical binding]; other site
205922014387	Walker B motif; other site
205922014388	arginine finger; other site
205922014389	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
205922014390	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
205922014391	YhhN-like protein; Region: YhhN; pfam07947
205922014392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922014393	S-adenosylmethionine binding site [chemical binding]; other site
205922014394	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922014395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922014396	S-adenosylmethionine binding site [chemical binding]; other site
205922014397	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
205922014398	nucleoside/Zn binding site; other site
205922014399	dimer interface [polypeptide binding]; other site
205922014400	catalytic motif [active]
205922014401	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
205922014402	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
205922014403	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
205922014404	C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647
205922014405	GMP synthase; Reviewed; Region: guaA; PRK00074
205922014406	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
205922014407	AMP/PPi binding site [chemical binding]; other site
205922014408	candidate oxyanion hole; other site
205922014409	catalytic triad [active]
205922014410	potential glutamine specificity residues [chemical binding]; other site
205922014411	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
205922014412	ATP Binding subdomain [chemical binding]; other site
205922014413	Ligand Binding sites [chemical binding]; other site
205922014414	Dimerization subdomain; other site
205922014415	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
205922014416	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
205922014417	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
205922014418	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
205922014419	active site
205922014420	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922014421	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
205922014422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922014423	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
205922014424	dimerization interface [polypeptide binding]; other site
205922014425	substrate binding pocket [chemical binding]; other site
205922014426	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
205922014427	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
205922014428	generic binding surface II; other site
205922014429	generic binding surface I; other site
205922014430	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
205922014431	Peptidase family M23; Region: Peptidase_M23; pfam01551
205922014432	2-isopropylmalate synthase; Validated; Region: PRK03739
205922014433	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
205922014434	active site
205922014435	catalytic residues [active]
205922014436	metal binding site [ion binding]; metal-binding site
205922014437	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
205922014438	C-N hydrolase family amidase; Provisional; Region: PRK10438
205922014439	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
205922014440	putative active site [active]
205922014441	catalytic triad [active]
205922014442	dimer interface [polypeptide binding]; other site
205922014443	multimer interface [polypeptide binding]; other site
205922014444	methionine aminotransferase; Validated; Region: PRK09082
205922014445	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922014446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922014447	homodimer interface [polypeptide binding]; other site
205922014448	catalytic residue [active]
205922014449	GTP-binding protein Der; Reviewed; Region: PRK00093
205922014450	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
205922014451	G1 box; other site
205922014452	GTP/Mg2+ binding site [chemical binding]; other site
205922014453	Switch I region; other site
205922014454	G2 box; other site
205922014455	Switch II region; other site
205922014456	G3 box; other site
205922014457	G4 box; other site
205922014458	G5 box; other site
205922014459	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
205922014460	G1 box; other site
205922014461	GTP/Mg2+ binding site [chemical binding]; other site
205922014462	Switch I region; other site
205922014463	G2 box; other site
205922014464	G3 box; other site
205922014465	Switch II region; other site
205922014466	G4 box; other site
205922014467	G5 box; other site
205922014468	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
205922014469	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
205922014470	Trp docking motif [polypeptide binding]; other site
205922014471	active site
205922014472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
205922014473	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
205922014474	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
205922014475	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
205922014476	dimer interface [polypeptide binding]; other site
205922014477	motif 1; other site
205922014478	active site
205922014479	motif 2; other site
205922014480	motif 3; other site
205922014481	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
205922014482	anticodon binding site; other site
205922014483	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
205922014484	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
205922014485	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
205922014486	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
205922014487	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922014488	non-specific DNA binding site [nucleotide binding]; other site
205922014489	salt bridge; other site
205922014490	sequence-specific DNA binding site [nucleotide binding]; other site
205922014491	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
205922014492	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
205922014493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922014494	binding surface
205922014495	TPR motif; other site
205922014496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922014497	binding surface
205922014498	TPR motif; other site
205922014499	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
205922014500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922014501	FeS/SAM binding site; other site
205922014502	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
205922014503	active site
205922014504	multimer interface [polypeptide binding]; other site
205922014505	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
205922014506	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
205922014507	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922014508	catalytic loop [active]
205922014509	iron binding site [ion binding]; other site
205922014510	chaperone protein HscA; Provisional; Region: hscA; PRK05183
205922014511	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
205922014512	nucleotide binding site [chemical binding]; other site
205922014513	putative NEF/HSP70 interaction site [polypeptide binding]; other site
205922014514	SBD interface [polypeptide binding]; other site
205922014515	co-chaperone HscB; Provisional; Region: hscB; PRK00294
205922014516	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205922014517	HSP70 interaction site [polypeptide binding]; other site
205922014518	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
205922014519	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
205922014520	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
205922014521	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
205922014522	trimerization site [polypeptide binding]; other site
205922014523	active site
205922014524	cysteine desulfurase; Provisional; Region: PRK14012
205922014525	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
205922014526	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
205922014527	catalytic residue [active]
205922014528	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
205922014529	Rrf2 family protein; Region: rrf2_super; TIGR00738
205922014530	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
205922014531	serine O-acetyltransferase; Region: cysE; TIGR01172
205922014532	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
205922014533	trimer interface [polypeptide binding]; other site
205922014534	active site
205922014535	substrate binding site [chemical binding]; other site
205922014536	CoA binding site [chemical binding]; other site
205922014537	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
205922014538	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
205922014539	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
205922014540	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
205922014541	active site
205922014542	dimerization interface [polypeptide binding]; other site
205922014543	hypothetical protein; Provisional; Region: PRK11280
205922014544	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
205922014545	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
205922014546	Protein export membrane protein; Region: SecD_SecF; pfam02355
205922014547	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
205922014548	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
205922014549	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
205922014550	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
205922014551	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
205922014552	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
205922014553	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
205922014554	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
205922014555	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
205922014556	Methyltransferase domain; Region: Methyltransf_26; pfam13659
205922014557	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
205922014558	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922014559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922014560	ATP binding site [chemical binding]; other site
205922014561	Mg2+ binding site [ion binding]; other site
205922014562	G-X-G motif; other site
205922014563	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205922014564	active site
205922014565	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
205922014566	active site
205922014567	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
205922014568	metal binding site [ion binding]; metal-binding site
205922014569	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
205922014570	putative active site [active]
205922014571	putative metal binding site [ion binding]; other site
205922014572	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
205922014573	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
205922014574	acetylornithine aminotransferase; Provisional; Region: PRK02627
205922014575	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922014576	inhibitor-cofactor binding pocket; inhibition site
205922014577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922014578	catalytic residue [active]
205922014579	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922014580	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922014581	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
205922014582	putative effector binding pocket; other site
205922014583	putative dimerization interface [polypeptide binding]; other site
205922014584	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922014585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922014586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922014587	Coenzyme A binding pocket [chemical binding]; other site
205922014588	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
205922014589	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
205922014590	homotrimer interaction site [polypeptide binding]; other site
205922014591	putative active site [active]
205922014592	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
205922014593	UbiA prenyltransferase family; Region: UbiA; pfam01040
205922014594	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
205922014595	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
205922014596	Subunit I/III interface [polypeptide binding]; other site
205922014597	Subunit III/IV interface [polypeptide binding]; other site
205922014598	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
205922014599	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
205922014600	D-pathway; other site
205922014601	Putative ubiquinol binding site [chemical binding]; other site
205922014602	Low-spin heme (heme b) binding site [chemical binding]; other site
205922014603	Putative water exit pathway; other site
205922014604	Binuclear center (heme o3/CuB) [ion binding]; other site
205922014605	K-pathway; other site
205922014606	Putative proton exit pathway; other site
205922014607	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
205922014608	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
205922014609	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
205922014610	disulfide bond formation protein B; Provisional; Region: PRK02110
205922014611	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
205922014612	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
205922014613	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
205922014614	heme-binding site [chemical binding]; other site
205922014615	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
205922014616	FAD binding pocket [chemical binding]; other site
205922014617	FAD binding motif [chemical binding]; other site
205922014618	phosphate binding motif [ion binding]; other site
205922014619	beta-alpha-beta structure motif; other site
205922014620	NAD binding pocket [chemical binding]; other site
205922014621	Heme binding  pocket [chemical binding]; other site
205922014622	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
205922014623	GAF domain; Region: GAF; pfam01590
205922014624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922014625	Walker A motif; other site
205922014626	ATP binding site [chemical binding]; other site
205922014627	Walker B motif; other site
205922014628	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
205922014629	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
205922014630	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
205922014631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014632	active site
205922014633	phosphorylation site [posttranslational modification]
205922014634	intermolecular recognition site; other site
205922014635	dimerization interface [polypeptide binding]; other site
205922014636	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922014637	Flagellin N-methylase; Region: FliB; pfam03692
205922014638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922014639	PAS fold; Region: PAS_3; pfam08447
205922014640	putative active site [active]
205922014641	heme pocket [chemical binding]; other site
205922014642	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922014643	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922014644	dimer interface [polypeptide binding]; other site
205922014645	putative CheW interface [polypeptide binding]; other site
205922014646	putative pectinesterase/pectinesterase inhibitor; Region: PLN02506
205922014647	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
205922014648	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922014649	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922014650	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
205922014651	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
205922014652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922014653	active site
205922014654	phosphorylation site [posttranslational modification]
205922014655	intermolecular recognition site; other site
205922014656	dimerization interface [polypeptide binding]; other site
205922014657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922014658	DNA binding site [nucleotide binding]
205922014659	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
205922014660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922014661	dimer interface [polypeptide binding]; other site
205922014662	phosphorylation site [posttranslational modification]
205922014663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922014664	ATP binding site [chemical binding]; other site
205922014665	Mg2+ binding site [ion binding]; other site
205922014666	G-X-G motif; other site
205922014667	outer membrane porin, OprD family; Region: OprD; pfam03573
205922014668	Cache domain; Region: Cache_1; pfam02743
205922014669	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922014670	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922014671	metal binding site [ion binding]; metal-binding site
205922014672	active site
205922014673	I-site; other site
205922014674	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
205922014675	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
205922014676	cell division protein FtsZ; Validated; Region: PRK09330
205922014677	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
205922014678	nucleotide binding site [chemical binding]; other site
205922014679	SulA interaction site; other site
205922014680	cell division protein FtsA; Region: ftsA; TIGR01174
205922014681	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
205922014682	nucleotide binding site [chemical binding]; other site
205922014683	Cell division protein FtsA; Region: FtsA; pfam14450
205922014684	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
205922014685	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
205922014686	Cell division protein FtsQ; Region: FtsQ; pfam03799
205922014687	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
205922014688	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
205922014689	ATP-grasp domain; Region: ATP-grasp_4; cl17255
205922014690	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
205922014691	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205922014692	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205922014693	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205922014694	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
205922014695	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
205922014696	active site
205922014697	homodimer interface [polypeptide binding]; other site
205922014698	cell division protein FtsW; Region: ftsW; TIGR02614
205922014699	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
205922014700	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205922014701	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
205922014702	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
205922014703	Mg++ binding site [ion binding]; other site
205922014704	putative catalytic motif [active]
205922014705	putative substrate binding site [chemical binding]; other site
205922014706	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205922014707	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
205922014708	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205922014709	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205922014710	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
205922014711	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205922014712	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205922014713	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205922014714	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
205922014715	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
205922014716	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
205922014717	Cell division protein FtsL; Region: FtsL; pfam04999
205922014718	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
205922014719	MraW methylase family; Region: Methyltransf_5; cl17771
205922014720	cell division protein MraZ; Reviewed; Region: PRK00326
205922014721	MraZ protein; Region: MraZ; pfam02381
205922014722	MraZ protein; Region: MraZ; pfam02381
205922014723	Predicted methyltransferases [General function prediction only]; Region: COG0313
205922014724	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
205922014725	putative SAM binding site [chemical binding]; other site
205922014726	putative homodimer interface [polypeptide binding]; other site
205922014727	LppC putative lipoprotein; Region: LppC; pfam04348
205922014728	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
205922014729	putative ligand binding site [chemical binding]; other site
205922014730	hypothetical protein; Reviewed; Region: PRK12497
205922014731	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
205922014732	dimer interface [polypeptide binding]; other site
205922014733	active site
205922014734	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
205922014735	BON domain; Region: BON; pfam04972
205922014736	BON domain; Region: BON; pfam04972
205922014737	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
205922014738	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
205922014739	stringent starvation protein A; Provisional; Region: sspA; PRK09481
205922014740	C-terminal domain interface [polypeptide binding]; other site
205922014741	putative GSH binding site (G-site) [chemical binding]; other site
205922014742	dimer interface [polypeptide binding]; other site
205922014743	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
205922014744	dimer interface [polypeptide binding]; other site
205922014745	N-terminal domain interface [polypeptide binding]; other site
205922014746	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
205922014747	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
205922014748	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
205922014749	Qi binding site; other site
205922014750	intrachain domain interface; other site
205922014751	interchain domain interface [polypeptide binding]; other site
205922014752	heme bH binding site [chemical binding]; other site
205922014753	heme bL binding site [chemical binding]; other site
205922014754	Qo binding site; other site
205922014755	interchain domain interface [polypeptide binding]; other site
205922014756	intrachain domain interface; other site
205922014757	Qi binding site; other site
205922014758	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
205922014759	Qo binding site; other site
205922014760	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
205922014761	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
205922014762	[2Fe-2S] cluster binding site [ion binding]; other site
205922014763	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
205922014764	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
205922014765	23S rRNA interface [nucleotide binding]; other site
205922014766	L3 interface [polypeptide binding]; other site
205922014767	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922014768	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922014769	active site
205922014770	catalytic tetrad [active]
205922014771	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
205922014772	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922014773	active site
205922014774	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922014775	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
205922014776	conserved cys residue [active]
205922014777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922014778	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922014779	Predicted ATPase [General function prediction only]; Region: COG1485
205922014780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
205922014781	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
205922014782	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
205922014783	active site
205922014784	HIGH motif; other site
205922014785	dimer interface [polypeptide binding]; other site
205922014786	KMSKS motif; other site
205922014787	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
205922014788	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
205922014789	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922014790	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
205922014791	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
205922014792	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
205922014793	ligand binding site [chemical binding]; other site
205922014794	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
205922014795	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
205922014796	active site
205922014797	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
205922014798	AAA ATPase domain; Region: AAA_16; pfam13191
205922014799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922014800	DNA binding residues [nucleotide binding]
205922014801	dimerization interface [polypeptide binding]; other site
205922014802	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
205922014803	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
205922014804	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
205922014805	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
205922014806	acyl-activating enzyme (AAE) consensus motif; other site
205922014807	AMP binding site [chemical binding]; other site
205922014808	active site
205922014809	CoA binding site [chemical binding]; other site
205922014810	LysE type translocator; Region: LysE; cl00565
205922014811	glycerate dehydrogenase; Provisional; Region: PRK06487
205922014812	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
205922014813	putative ligand binding site [chemical binding]; other site
205922014814	putative NAD binding site [chemical binding]; other site
205922014815	catalytic site [active]
205922014816	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
205922014817	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
205922014818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922014819	S-adenosylmethionine binding site [chemical binding]; other site
205922014820	Predicted membrane protein [Function unknown]; Region: COG2119
205922014821	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
205922014822	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
205922014823	Peptidase family M48; Region: Peptidase_M48; pfam01435
205922014824	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922014825	dimerization interface [polypeptide binding]; other site
205922014826	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922014827	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922014828	dimer interface [polypeptide binding]; other site
205922014829	putative CheW interface [polypeptide binding]; other site
205922014830	Uncharacterized conserved protein [Function unknown]; Region: COG2135
205922014831	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
205922014832	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
205922014833	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
205922014834	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922014835	putative acyl-acceptor binding pocket; other site
205922014836	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
205922014837	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
205922014838	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922014839	active site
205922014840	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922014841	active site
205922014842	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
205922014843	ferrochelatase; Reviewed; Region: hemH; PRK00035
205922014844	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
205922014845	C-terminal domain interface [polypeptide binding]; other site
205922014846	active site
205922014847	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
205922014848	active site
205922014849	N-terminal domain interface [polypeptide binding]; other site
205922014850	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
205922014851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922014852	NAD(P) binding site [chemical binding]; other site
205922014853	active site
205922014854	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
205922014855	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922014856	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
205922014857	Protein of unknown function (DUF523); Region: DUF523; pfam04463
205922014858	Uncharacterized conserved protein [Function unknown]; Region: COG3272
205922014859	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
205922014860	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
205922014861	DNA binding residues [nucleotide binding]
205922014862	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
205922014863	B12 binding domain; Region: B12-binding_2; pfam02607
205922014864	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
205922014865	DNA photolyase; Region: DNA_photolyase; pfam00875
205922014866	SnoaL-like domain; Region: SnoaL_2; pfam12680
205922014867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922014868	short chain dehydrogenase; Provisional; Region: PRK06101
205922014869	NAD(P) binding site [chemical binding]; other site
205922014870	active site
205922014871	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
205922014872	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922014873	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922014874	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
205922014875	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
205922014876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922014877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922014878	S-adenosylmethionine binding site [chemical binding]; other site
205922014879	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
205922014880	Flagellin N-methylase; Region: FliB; pfam03692
205922014881	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
205922014882	glutamate racemase; Provisional; Region: PRK00865
205922014883	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
205922014884	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
205922014885	ATP binding site [chemical binding]; other site
205922014886	substrate interface [chemical binding]; other site
205922014887	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
205922014888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922014889	S-adenosylmethionine binding site [chemical binding]; other site
205922014890	peptide chain release factor 1; Validated; Region: prfA; PRK00591
205922014891	This domain is found in peptide chain release factors; Region: PCRF; smart00937
205922014892	RF-1 domain; Region: RF-1; pfam00472
205922014893	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
205922014894	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
205922014895	tRNA; other site
205922014896	putative tRNA binding site [nucleotide binding]; other site
205922014897	putative NADP binding site [chemical binding]; other site
205922014898	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
205922014899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922014900	binding surface
205922014901	TPR motif; other site
205922014902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922014903	binding surface
205922014904	TPR motif; other site
205922014905	TPR repeat; Region: TPR_11; pfam13414
205922014906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922014907	binding surface
205922014908	TPR motif; other site
205922014909	TPR repeat; Region: TPR_11; pfam13414
205922014910	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
205922014911	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
205922014912	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
205922014913	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
205922014914	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
205922014915	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
205922014916	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922014917	active site
205922014918	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
205922014919	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
205922014920	5S rRNA interface [nucleotide binding]; other site
205922014921	CTC domain interface [polypeptide binding]; other site
205922014922	L16 interface [polypeptide binding]; other site
205922014923	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
205922014924	putative active site [active]
205922014925	catalytic residue [active]
205922014926	GTP-binding protein YchF; Reviewed; Region: PRK09601
205922014927	YchF GTPase; Region: YchF; cd01900
205922014928	G1 box; other site
205922014929	GTP/Mg2+ binding site [chemical binding]; other site
205922014930	Switch I region; other site
205922014931	G2 box; other site
205922014932	Switch II region; other site
205922014933	G3 box; other site
205922014934	G4 box; other site
205922014935	G5 box; other site
205922014936	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
205922014937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922014938	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922014939	putative substrate translocation pore; other site
205922014940	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922014941	dimer interface [polypeptide binding]; other site
205922014942	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
205922014943	putative CheW interface [polypeptide binding]; other site
205922014944	S-type Pyocin; Region: Pyocin_S; pfam06958
205922014945	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
205922014946	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
205922014947	S-type Pyocin; Region: Pyocin_S; pfam06958
205922014948	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
205922014949	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
205922014950	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
205922014951	putative active site [active]
205922014952	Zn binding site [ion binding]; other site
205922014953	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
205922014954	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
205922014955	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
205922014956	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922014957	PAS domain; Region: PAS_9; pfam13426
205922014958	putative active site [active]
205922014959	heme pocket [chemical binding]; other site
205922014960	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922014961	PAS domain; Region: PAS_9; pfam13426
205922014962	putative active site [active]
205922014963	heme pocket [chemical binding]; other site
205922014964	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922014965	dimer interface [polypeptide binding]; other site
205922014966	putative CheW interface [polypeptide binding]; other site
205922014967	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922014968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922014969	putative substrate translocation pore; other site
205922014970	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
205922014971	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
205922014972	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
205922014973	nucleotide binding site [chemical binding]; other site
205922014974	putative NEF/HSP70 interaction site [polypeptide binding]; other site
205922014975	SBD interface [polypeptide binding]; other site
205922014976	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205922014977	HSP70 interaction site [polypeptide binding]; other site
205922014978	SET domain; Region: SET; cl02566
205922014979	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
205922014980	active site clefts [active]
205922014981	zinc binding site [ion binding]; other site
205922014982	dimer interface [polypeptide binding]; other site
205922014983	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
205922014984	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922014985	Coenzyme A binding pocket [chemical binding]; other site
205922014986	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
205922014987	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
205922014988	mce related protein; Region: MCE; pfam02470
205922014989	mce related protein; Region: MCE; pfam02470
205922014990	mce related protein; Region: MCE; pfam02470
205922014991	mce related protein; Region: MCE; pfam02470
205922014992	mce related protein; Region: MCE; pfam02470
205922014993	mce related protein; Region: MCE; pfam02470
205922014994	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
205922014995	Paraquat-inducible protein A; Region: PqiA; pfam04403
205922014996	Paraquat-inducible protein A; Region: PqiA; pfam04403
205922014997	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
205922014998	TMAO/DMSO reductase; Reviewed; Region: PRK05363
205922014999	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
205922015000	Moco binding site; other site
205922015001	metal coordination site [ion binding]; other site
205922015002	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
205922015003	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
205922015004	ketol-acid reductoisomerase; Provisional; Region: PRK05479
205922015005	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
205922015006	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
205922015007	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
205922015008	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
205922015009	putative valine binding site [chemical binding]; other site
205922015010	dimer interface [polypeptide binding]; other site
205922015011	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
205922015012	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
205922015013	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
205922015014	PYR/PP interface [polypeptide binding]; other site
205922015015	dimer interface [polypeptide binding]; other site
205922015016	TPP binding site [chemical binding]; other site
205922015017	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
205922015018	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
205922015019	TPP-binding site [chemical binding]; other site
205922015020	dimer interface [polypeptide binding]; other site
205922015021	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
205922015022	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
205922015023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
205922015024	Tetratricopeptide repeat; Region: TPR_16; pfam13432
205922015025	TPR motif; other site
205922015026	binding surface
205922015027	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
205922015028	Transglycosylase; Region: Transgly; pfam00912
205922015029	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
205922015030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
205922015031	AAA domain; Region: AAA_33; pfam13671
205922015032	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
205922015033	ATP-binding site [chemical binding]; other site
205922015034	Gluconate-6-phosphate binding site [chemical binding]; other site
205922015035	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
205922015036	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
205922015037	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
205922015038	TfoX C-terminal domain; Region: TfoX_C; pfam04994
205922015039	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
205922015040	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922015041	ligand binding site [chemical binding]; other site
205922015042	flexible hinge region; other site
205922015043	Protein of unknown function, DUF399; Region: DUF399; cl01139
205922015044	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
205922015045	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
205922015046	Walker A/P-loop; other site
205922015047	ATP binding site [chemical binding]; other site
205922015048	Q-loop/lid; other site
205922015049	ABC transporter signature motif; other site
205922015050	Walker B; other site
205922015051	D-loop; other site
205922015052	H-loop/switch region; other site
205922015053	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205922015054	ABC-ATPase subunit  interface; other site
205922015055	dimer interface [polypeptide binding]; other site
205922015056	putative PBP binding regions; other site
205922015057	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
205922015058	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
205922015059	intersubunit interface [polypeptide binding]; other site
205922015060	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
205922015061	iron-sulfur cluster [ion binding]; other site
205922015062	[2Fe-2S] cluster binding site [ion binding]; other site
205922015063	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
205922015064	hypothetical protein; Provisional; Region: PRK08960
205922015065	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922015066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922015067	homodimer interface [polypeptide binding]; other site
205922015068	catalytic residue [active]
205922015069	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
205922015070	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
205922015071	active site
205922015072	nucleotide binding site [chemical binding]; other site
205922015073	HIGH motif; other site
205922015074	KMSKS motif; other site
205922015075	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
205922015076	Na binding site [ion binding]; other site
205922015077	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205922015078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922015079	putative active site [active]
205922015080	heme pocket [chemical binding]; other site
205922015081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922015082	dimer interface [polypeptide binding]; other site
205922015083	phosphorylation site [posttranslational modification]
205922015084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922015085	ATP binding site [chemical binding]; other site
205922015086	Mg2+ binding site [ion binding]; other site
205922015087	G-X-G motif; other site
205922015088	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922015089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922015090	active site
205922015091	phosphorylation site [posttranslational modification]
205922015092	intermolecular recognition site; other site
205922015093	dimerization interface [polypeptide binding]; other site
205922015094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922015095	Walker A motif; other site
205922015096	ATP binding site [chemical binding]; other site
205922015097	Walker B motif; other site
205922015098	arginine finger; other site
205922015099	poly(A) polymerase; Region: pcnB; TIGR01942
205922015100	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
205922015101	active site
205922015102	NTP binding site [chemical binding]; other site
205922015103	metal binding triad [ion binding]; metal-binding site
205922015104	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
205922015105	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
205922015106	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
205922015107	catalytic center binding site [active]
205922015108	ATP binding site [chemical binding]; other site
205922015109	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
205922015110	oligomerization interface [polypeptide binding]; other site
205922015111	active site
205922015112	metal binding site [ion binding]; metal-binding site
205922015113	Pantoate-beta-alanine ligase; Region: PanC; cd00560
205922015114	pantoate--beta-alanine ligase; Region: panC; TIGR00018
205922015115	active site
205922015116	ATP-binding site [chemical binding]; other site
205922015117	pantoate-binding site; other site
205922015118	HXXH motif; other site
205922015119	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
205922015120	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
205922015121	active site
205922015122	dimer interface [polypeptide binding]; other site
205922015123	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
205922015124	dimer interface [polypeptide binding]; other site
205922015125	active site
205922015126	acetyl-CoA synthetase; Provisional; Region: PRK00174
205922015127	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
205922015128	active site
205922015129	CoA binding site [chemical binding]; other site
205922015130	acyl-activating enzyme (AAE) consensus motif; other site
205922015131	AMP binding site [chemical binding]; other site
205922015132	acetate binding site [chemical binding]; other site
205922015133	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
205922015134	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
205922015135	putative RNA binding site [nucleotide binding]; other site
205922015136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922015137	S-adenosylmethionine binding site [chemical binding]; other site
205922015138	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
205922015139	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
205922015140	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
205922015141	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
205922015142	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
205922015143	BON domain; Region: BON; pfam04972
205922015144	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
205922015145	Pilin (bacterial filament); Region: Pilin; pfam00114
205922015146	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
205922015147	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
205922015148	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
205922015149	Walker A motif; other site
205922015150	ATP binding site [chemical binding]; other site
205922015151	Walker B motif; other site
205922015152	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
205922015153	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922015154	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
205922015155	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
205922015156	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
205922015157	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
205922015158	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
205922015159	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
205922015160	CoA-binding site [chemical binding]; other site
205922015161	ATP-binding [chemical binding]; other site
205922015162	DNA gyrase inhibitor; Reviewed; Region: PRK00418
205922015163	Predicted membrane protein [Function unknown]; Region: COG3235
205922015164	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
205922015165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
205922015166	MOSC domain; Region: MOSC; pfam03473
205922015167	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
205922015168	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
205922015169	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922015170	EF-hand domain pair; Region: EF_hand_5; pfam13499
205922015171	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
205922015172	Ca2+ binding site [ion binding]; other site
205922015173	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
205922015174	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922015175	dimerization interface [polypeptide binding]; other site
205922015176	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922015177	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922015178	dimer interface [polypeptide binding]; other site
205922015179	putative CheW interface [polypeptide binding]; other site
205922015180	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
205922015181	Clp amino terminal domain; Region: Clp_N; pfam02861
205922015182	Clp amino terminal domain; Region: Clp_N; pfam02861
205922015183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922015184	Walker A motif; other site
205922015185	ATP binding site [chemical binding]; other site
205922015186	Walker B motif; other site
205922015187	arginine finger; other site
205922015188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922015189	Walker A motif; other site
205922015190	ATP binding site [chemical binding]; other site
205922015191	Walker B motif; other site
205922015192	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
205922015193	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
205922015194	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
205922015195	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
205922015196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922015197	RNA binding surface [nucleotide binding]; other site
205922015198	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
205922015199	active site
205922015200	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
205922015201	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
205922015202	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
205922015203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922015204	dimer interface [polypeptide binding]; other site
205922015205	phosphorylation site [posttranslational modification]
205922015206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922015207	ATP binding site [chemical binding]; other site
205922015208	Mg2+ binding site [ion binding]; other site
205922015209	G-X-G motif; other site
205922015210	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
205922015211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922015212	active site
205922015213	phosphorylation site [posttranslational modification]
205922015214	intermolecular recognition site; other site
205922015215	dimerization interface [polypeptide binding]; other site
205922015216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922015217	Walker A motif; other site
205922015218	ATP binding site [chemical binding]; other site
205922015219	Walker B motif; other site
205922015220	arginine finger; other site
205922015221	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922015222	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
205922015223	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922015224	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
205922015225	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
205922015226	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
205922015227	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
205922015228	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
205922015229	Type II transport protein GspH; Region: GspH; pfam12019
205922015230	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
205922015231	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
205922015232	Type II transport protein GspH; Region: GspH; pfam12019
205922015233	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
205922015234	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
205922015235	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
205922015236	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205922015237	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
205922015238	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
205922015239	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205922015240	active site
205922015241	HIGH motif; other site
205922015242	nucleotide binding site [chemical binding]; other site
205922015243	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
205922015244	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
205922015245	active site
205922015246	KMSKS motif; other site
205922015247	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
205922015248	tRNA binding surface [nucleotide binding]; other site
205922015249	anticodon binding site; other site
205922015250	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
205922015251	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
205922015252	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
205922015253	active site
205922015254	Riboflavin kinase; Region: Flavokinase; smart00904
205922015255	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
205922015256	MviN-like protein; Region: MVIN; pfam03023
205922015257	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
205922015258	CreA protein; Region: CreA; pfam05981
205922015259	gamma-glutamyl kinase; Provisional; Region: PRK05429
205922015260	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
205922015261	nucleotide binding site [chemical binding]; other site
205922015262	homotetrameric interface [polypeptide binding]; other site
205922015263	putative phosphate binding site [ion binding]; other site
205922015264	putative allosteric binding site; other site
205922015265	PUA domain; Region: PUA; pfam01472
205922015266	GTPase CgtA; Reviewed; Region: obgE; PRK12298
205922015267	GTP1/OBG; Region: GTP1_OBG; pfam01018
205922015268	Obg GTPase; Region: Obg; cd01898
205922015269	G1 box; other site
205922015270	GTP/Mg2+ binding site [chemical binding]; other site
205922015271	Switch I region; other site
205922015272	G2 box; other site
205922015273	G3 box; other site
205922015274	Switch II region; other site
205922015275	G4 box; other site
205922015276	G5 box; other site
205922015277	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
205922015278	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
205922015279	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
205922015280	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
205922015281	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
205922015282	substrate binding pocket [chemical binding]; other site
205922015283	chain length determination region; other site
205922015284	substrate-Mg2+ binding site; other site
205922015285	catalytic residues [active]
205922015286	aspartate-rich region 1; other site
205922015287	active site lid residues [active]
205922015288	aspartate-rich region 2; other site
205922015289	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
205922015290	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
205922015291	PhnA protein; Region: PhnA; pfam03831
205922015292	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
205922015293	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
205922015294	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205922015295	hypothetical protein; Provisional; Region: PRK05208
205922015296	AAA domain; Region: AAA_32; pfam13654
205922015297	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
205922015298	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
205922015299	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
205922015300	transcription elongation factor regulatory protein; Validated; Region: PRK06342
205922015301	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
205922015302	glutamate dehydrogenase; Provisional; Region: PRK09414
205922015303	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
205922015304	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
205922015305	NAD(P) binding site [chemical binding]; other site
205922015306	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
205922015307	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922015308	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922015309	ABC transporter; Region: ABC_tran_2; pfam12848
205922015310	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922015311	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
205922015312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922015313	putative active site [active]
205922015314	heme pocket [chemical binding]; other site
205922015315	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
205922015316	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922015317	putative active site [active]
205922015318	heme pocket [chemical binding]; other site
205922015319	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922015320	metal binding site [ion binding]; metal-binding site
205922015321	active site
205922015322	I-site; other site
205922015323	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922015324	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
205922015325	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
205922015326	dimer interface [polypeptide binding]; other site
205922015327	active site
205922015328	glycine-pyridoxal phosphate binding site [chemical binding]; other site
205922015329	folate binding site [chemical binding]; other site
205922015330	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
205922015331	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922015332	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922015333	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922015334	DNA-binding site [nucleotide binding]; DNA binding site
205922015335	FCD domain; Region: FCD; pfam07729
205922015336	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
205922015337	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
205922015338	DNA-binding site [nucleotide binding]; DNA binding site
205922015339	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
205922015340	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
205922015341	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
205922015342	P-loop, Walker A motif; other site
205922015343	Base recognition motif; other site
205922015344	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
205922015345	Protein of unknown function (DUF466); Region: DUF466; pfam04328
205922015346	carbon starvation protein A; Provisional; Region: PRK15015
205922015347	Carbon starvation protein CstA; Region: CstA; pfam02554
205922015348	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
205922015349	PilZ domain; Region: PilZ; pfam07238
205922015350	DNA repair protein RadA; Provisional; Region: PRK11823
205922015351	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205922015352	Walker A motif; other site
205922015353	ATP binding site [chemical binding]; other site
205922015354	Walker B motif; other site
205922015355	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
205922015356	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
205922015357	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
205922015358	tetramer interface [polypeptide binding]; other site
205922015359	heme binding pocket [chemical binding]; other site
205922015360	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
205922015361	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
205922015362	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
205922015363	ferredoxin-NADP reductase; Provisional; Region: PRK10926
205922015364	FAD binding pocket [chemical binding]; other site
205922015365	FAD binding motif [chemical binding]; other site
205922015366	phosphate binding motif [ion binding]; other site
205922015367	beta-alpha-beta structure motif; other site
205922015368	NAD binding pocket [chemical binding]; other site
205922015369	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
205922015370	Autoinducer binding domain; Region: Autoind_bind; pfam03472
205922015371	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922015372	DNA binding residues [nucleotide binding]
205922015373	dimerization interface [polypeptide binding]; other site
205922015374	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
205922015375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922015376	S-adenosylmethionine binding site [chemical binding]; other site
205922015377	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
205922015378	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
205922015379	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
205922015380	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
205922015381	H+ Antiporter protein; Region: 2A0121; TIGR00900
205922015382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922015383	putative substrate translocation pore; other site
205922015384	DJ-1 family protein; Region: not_thiJ; TIGR01383
205922015385	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
205922015386	conserved cys residue [active]
205922015387	Vi polysaccharide export protein VexE; Provisional; Region: PRK15174
205922015388	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
205922015389	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
205922015390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922015391	S-adenosylmethionine binding site [chemical binding]; other site
205922015392	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
205922015393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922015394	LysR family transcriptional regulator; Provisional; Region: PRK14997
205922015395	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
205922015396	putative effector binding pocket; other site
205922015397	dimerization interface [polypeptide binding]; other site
205922015398	Dehydroquinase class II; Region: DHquinase_II; pfam01220
205922015399	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
205922015400	active site
205922015401	trimer interface [polypeptide binding]; other site
205922015402	dimer interface [polypeptide binding]; other site
205922015403	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
205922015404	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
205922015405	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
205922015406	shikimate binding site; other site
205922015407	NAD(P) binding site [chemical binding]; other site
205922015408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922015409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922015410	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
205922015411	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
205922015412	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
205922015413	dimer interface [polypeptide binding]; other site
205922015414	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
205922015415	active site
205922015416	Fe binding site [ion binding]; other site
205922015417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922015418	D-galactonate transporter; Region: 2A0114; TIGR00893
205922015419	putative substrate translocation pore; other site
205922015420	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
205922015421	EamA-like transporter family; Region: EamA; pfam00892
205922015422	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
205922015423	Transcriptional regulator [Transcription]; Region: IclR; COG1414
205922015424	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
205922015425	Bacterial transcriptional regulator; Region: IclR; pfam01614
205922015426	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
205922015427	Predicted oxidoreductase [General function prediction only]; Region: COG3573
205922015428	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
205922015429	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
205922015430	active site
205922015431	catalytic tetrad [active]
205922015432	Predicted metalloprotease [General function prediction only]; Region: COG2321
205922015433	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
205922015434	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
205922015435	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922015436	active site
205922015437	motif I; other site
205922015438	motif II; other site
205922015439	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
205922015440	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
205922015441	active site
205922015442	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
205922015443	catalytic triad [active]
205922015444	dimer interface [polypeptide binding]; other site
205922015445	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922015446	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
205922015447	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
205922015448	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
205922015449	putative active site [active]
205922015450	Zn binding site [ion binding]; other site
205922015451	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922015452	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
205922015453	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205922015454	DEAD-like helicases superfamily; Region: DEXDc; smart00487
205922015455	ATP binding site [chemical binding]; other site
205922015456	Mg++ binding site [ion binding]; other site
205922015457	motif III; other site
205922015458	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922015459	nucleotide binding region [chemical binding]; other site
205922015460	ATP-binding site [chemical binding]; other site
205922015461	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
205922015462	EamA-like transporter family; Region: EamA; pfam00892
205922015463	EamA-like transporter family; Region: EamA; pfam00892
205922015464	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
205922015465	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922015466	putative DNA binding site [nucleotide binding]; other site
205922015467	putative Zn2+ binding site [ion binding]; other site
205922015468	AsnC family; Region: AsnC_trans_reg; pfam01037
205922015469	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
205922015470	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
205922015471	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
205922015472	active site
205922015473	catalytic site [active]
205922015474	substrate binding site [chemical binding]; other site
205922015475	Uncharacterized conserved protein [Function unknown]; Region: COG1432
205922015476	LabA_like proteins; Region: LabA; cd10911
205922015477	putative metal binding site [ion binding]; other site
205922015478	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
205922015479	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
205922015480	putative catalytic site [active]
205922015481	putative metal binding site [ion binding]; other site
205922015482	putative phosphate binding site [ion binding]; other site
205922015483	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
205922015484	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922015485	Walker A/P-loop; other site
205922015486	ATP binding site [chemical binding]; other site
205922015487	Q-loop/lid; other site
205922015488	ABC transporter signature motif; other site
205922015489	Walker B; other site
205922015490	D-loop; other site
205922015491	H-loop/switch region; other site
205922015492	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922015493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922015494	dimer interface [polypeptide binding]; other site
205922015495	conserved gate region; other site
205922015496	putative PBP binding loops; other site
205922015497	ABC-ATPase subunit interface; other site
205922015498	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
205922015499	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922015500	membrane-bound complex binding site; other site
205922015501	hinge residues; other site
205922015502	putative aminotransferase; Provisional; Region: PRK12403
205922015503	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922015504	inhibitor-cofactor binding pocket; inhibition site
205922015505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922015506	catalytic residue [active]
205922015507	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
205922015508	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
205922015509	NAD(P) binding site [chemical binding]; other site
205922015510	catalytic residues [active]
205922015511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922015512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922015513	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
205922015514	putative substrate binding pocket [chemical binding]; other site
205922015515	dimerization interface [polypeptide binding]; other site
205922015516	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
205922015517	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922015518	ATP binding site [chemical binding]; other site
205922015519	putative Mg++ binding site [ion binding]; other site
205922015520	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922015521	nucleotide binding region [chemical binding]; other site
205922015522	ATP-binding site [chemical binding]; other site
205922015523	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
205922015524	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
205922015525	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
205922015526	Cation efflux family; Region: Cation_efflux; cl00316
205922015527	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
205922015528	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
205922015529	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922015530	putative DNA binding site [nucleotide binding]; other site
205922015531	putative Zn2+ binding site [ion binding]; other site
205922015532	AsnC family; Region: AsnC_trans_reg; pfam01037
205922015533	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
205922015534	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
205922015535	pseudouridine synthase; Region: TIGR00093
205922015536	active site
205922015537	AMP nucleosidase; Provisional; Region: PRK08292
205922015538	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
205922015539	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
205922015540	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
205922015541	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922015542	active site
205922015543	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
205922015544	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
205922015545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922015546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922015547	dimer interface [polypeptide binding]; other site
205922015548	phosphorylation site [posttranslational modification]
205922015549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922015550	ATP binding site [chemical binding]; other site
205922015551	Mg2+ binding site [ion binding]; other site
205922015552	G-X-G motif; other site
205922015553	Response regulator receiver domain; Region: Response_reg; pfam00072
205922015554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922015555	active site
205922015556	phosphorylation site [posttranslational modification]
205922015557	intermolecular recognition site; other site
205922015558	dimerization interface [polypeptide binding]; other site
205922015559	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
205922015560	dimer interface [polypeptide binding]; other site
205922015561	substrate binding site [chemical binding]; other site
205922015562	ATP binding site [chemical binding]; other site
205922015563	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
205922015564	thiamine phosphate binding site [chemical binding]; other site
205922015565	active site
205922015566	pyrophosphate binding site [ion binding]; other site
205922015567	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
205922015568	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922015569	inhibitor-cofactor binding pocket; inhibition site
205922015570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922015571	catalytic residue [active]
205922015572	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
205922015573	Sel1-like repeats; Region: SEL1; smart00671
205922015574	Sel1-like repeats; Region: SEL1; smart00671
205922015575	Domain of unknown function (DUF1820); Region: DUF1820; cl11545
205922015576	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
205922015577	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
205922015578	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922015579	FeS/SAM binding site; other site
205922015580	TRAM domain; Region: TRAM; pfam01938
205922015581	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
205922015582	PhoH-like protein; Region: PhoH; pfam02562
205922015583	metal-binding heat shock protein; Provisional; Region: PRK00016
205922015584	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
205922015585	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
205922015586	Transporter associated domain; Region: CorC_HlyC; smart01091
205922015587	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
205922015588	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
205922015589	putative active site [active]
205922015590	catalytic triad [active]
205922015591	putative dimer interface [polypeptide binding]; other site
205922015592	Uncharacterized conserved protein [Function unknown]; Region: COG1434
205922015593	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
205922015594	putative active site [active]
205922015595	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
205922015596	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
205922015597	HIGH motif; other site
205922015598	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
205922015599	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205922015600	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
205922015601	active site
205922015602	KMSKS motif; other site
205922015603	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
205922015604	tRNA binding surface [nucleotide binding]; other site
205922015605	Lipopolysaccharide-assembly; Region: LptE; cl01125
205922015606	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
205922015607	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
205922015608	Domain of unknown function; Region: DUF331; cl01149
205922015609	Transglycosylase SLT domain; Region: SLT_2; pfam13406
205922015610	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922015611	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922015612	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
205922015613	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
205922015614	dimer interface [polypeptide binding]; other site
205922015615	catalytic triad [active]
205922015616	lipoyl synthase; Provisional; Region: PRK05481
205922015617	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922015618	FeS/SAM binding site; other site
205922015619	lipoate-protein ligase B; Provisional; Region: PRK14342
205922015620	hypothetical protein; Provisional; Region: PRK00341
205922015621	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
205922015622	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
205922015623	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
205922015624	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
205922015625	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
205922015626	Sporulation related domain; Region: SPOR; pfam05036
205922015627	Transglycosylase SLT domain; Region: SLT_2; pfam13406
205922015628	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
205922015629	N-acetyl-D-glucosamine binding site [chemical binding]; other site
205922015630	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
205922015631	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
205922015632	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
205922015633	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
205922015634	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
205922015635	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
205922015636	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
205922015637	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
205922015638	active site
205922015639	(T/H)XGH motif; other site
205922015640	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
205922015641	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
205922015642	putative catalytic cysteine [active]
205922015643	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
205922015644	active site
205922015645	DNA binding site [nucleotide binding]
205922015646	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
205922015647	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
205922015648	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
205922015649	active site
205922015650	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
205922015651	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
205922015652	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
205922015653	LrgA family; Region: LrgA; cl00608
205922015654	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
205922015655	putative active site [active]
205922015656	putative catalytic site [active]
205922015657	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
205922015658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
205922015659	Peptidase C13 family; Region: Peptidase_C13; cl02159
205922015660	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
205922015661	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
205922015662	NAD binding site [chemical binding]; other site
205922015663	active site
205922015664	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
205922015665	aromatic acid decarboxylase; Validated; Region: PRK05920
205922015666	Flavoprotein; Region: Flavoprotein; pfam02441
205922015667	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
205922015668	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
205922015669	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
205922015670	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
205922015671	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
205922015672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922015673	Walker A motif; other site
205922015674	ATP binding site [chemical binding]; other site
205922015675	Walker B motif; other site
205922015676	arginine finger; other site
205922015677	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922015678	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
205922015679	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
205922015680	NAD(P) binding site [chemical binding]; other site
205922015681	catalytic residues [active]
205922015682	ethanolamine permease; Region: 2A0305; TIGR00908
205922015683	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
205922015684	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
205922015685	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
205922015686	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922015687	Coenzyme A binding pocket [chemical binding]; other site
205922015688	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
205922015689	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
205922015690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228
205922015691	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
205922015692	dimer interface [polypeptide binding]; other site
205922015693	substrate binding site [chemical binding]; other site
205922015694	metal binding sites [ion binding]; metal-binding site
205922015695	Predicted transcriptional regulator [Transcription]; Region: COG2932
205922015696	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
205922015697	Catalytic site [active]
205922015698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
205922015699	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
205922015700	Predicted secreted protein [Function unknown]; Region: COG5445
205922015701	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
205922015702	Predicted secreted protein [Function unknown]; Region: COG5445
205922015703	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
205922015704	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
205922015705	MG2 domain; Region: A2M_N; pfam01835
205922015706	Alpha-2-macroglobulin family; Region: A2M; pfam00207
205922015707	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
205922015708	surface patch; other site
205922015709	thioester region; other site
205922015710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234
205922015711	Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909
205922015712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
205922015713	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
205922015714	Fic family protein [Function unknown]; Region: COG3177
205922015715	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
205922015716	Fic/DOC family; Region: Fic; pfam02661
205922015717	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
205922015718	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
205922015719	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
205922015720	substrate binding pocket [chemical binding]; other site
205922015721	chain length determination region; other site
205922015722	substrate-Mg2+ binding site; other site
205922015723	catalytic residues [active]
205922015724	aspartate-rich region 1; other site
205922015725	active site lid residues [active]
205922015726	aspartate-rich region 2; other site
205922015727	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
205922015728	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
205922015729	TPP-binding site; other site
205922015730	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
205922015731	PYR/PP interface [polypeptide binding]; other site
205922015732	dimer interface [polypeptide binding]; other site
205922015733	TPP binding site [chemical binding]; other site
205922015734	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205922015735	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
205922015736	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922015737	N-terminal plug; other site
205922015738	ligand-binding site [chemical binding]; other site
205922015739	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
205922015740	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
205922015741	cobalamin binding residues [chemical binding]; other site
205922015742	putative BtuC binding residues; other site
205922015743	dimer interface [polypeptide binding]; other site
205922015744	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
205922015745	dimerization interface [polypeptide binding]; other site
205922015746	active site
205922015747	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922015748	substrate binding pocket [chemical binding]; other site
205922015749	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922015750	membrane-bound complex binding site; other site
205922015751	hinge residues; other site
205922015752	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
205922015753	tetramer interfaces [polypeptide binding]; other site
205922015754	binuclear metal-binding site [ion binding]; other site
205922015755	thiamine monophosphate kinase; Provisional; Region: PRK05731
205922015756	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
205922015757	ATP binding site [chemical binding]; other site
205922015758	dimerization interface [polypeptide binding]; other site
205922015759	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
205922015760	putative RNA binding site [nucleotide binding]; other site
205922015761	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
205922015762	homopentamer interface [polypeptide binding]; other site
205922015763	active site
205922015764	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
205922015765	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
205922015766	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
205922015767	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
205922015768	Lumazine binding domain; Region: Lum_binding; pfam00677
205922015769	Lumazine binding domain; Region: Lum_binding; pfam00677
205922015770	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
205922015771	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
205922015772	catalytic motif [active]
205922015773	Zn binding site [ion binding]; other site
205922015774	RibD C-terminal domain; Region: RibD_C; cl17279
205922015775	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
205922015776	ATP cone domain; Region: ATP-cone; pfam03477
205922015777	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
205922015778	Predicted methyltransferase [General function prediction only]; Region: COG3897
205922015779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
205922015780	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
205922015781	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
205922015782	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
205922015783	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
205922015784	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
205922015785	Walker A/P-loop; other site
205922015786	ATP binding site [chemical binding]; other site
205922015787	Q-loop/lid; other site
205922015788	ABC transporter signature motif; other site
205922015789	Walker B; other site
205922015790	D-loop; other site
205922015791	H-loop/switch region; other site
205922015792	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
205922015793	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
205922015794	FtsX-like permease family; Region: FtsX; pfam02687
205922015795	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
205922015796	OmpW family; Region: OmpW; cl17427
205922015797	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922015798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922015799	NAD(P) binding site [chemical binding]; other site
205922015800	active site
205922015801	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
205922015802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922015803	NAD(P) binding site [chemical binding]; other site
205922015804	active site
205922015805	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
205922015806	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922015807	ATP binding site [chemical binding]; other site
205922015808	putative Mg++ binding site [ion binding]; other site
205922015809	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922015810	nucleotide binding region [chemical binding]; other site
205922015811	ATP-binding site [chemical binding]; other site
205922015812	DEAD/H associated; Region: DEAD_assoc; pfam08494
205922015813	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922015814	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922015815	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
205922015816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922015817	putative substrate translocation pore; other site
205922015818	Protein of unknown function DUF72; Region: DUF72; pfam01904
205922015819	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
205922015820	putative catalytic site [active]
205922015821	putative metal binding site [ion binding]; other site
205922015822	putative phosphate binding site [ion binding]; other site
205922015823	cardiolipin synthase 2; Provisional; Region: PRK11263
205922015824	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
205922015825	putative active site [active]
205922015826	catalytic site [active]
205922015827	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
205922015828	putative active site [active]
205922015829	catalytic site [active]
205922015830	Predicted integral membrane protein [Function unknown]; Region: COG0392
205922015831	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
205922015832	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922015833	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
205922015834	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922015835	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
205922015836	conserved cys residue [active]
205922015837	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922015838	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922015839	Isochorismatase family; Region: Isochorismatase; pfam00857
205922015840	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
205922015841	catalytic triad [active]
205922015842	conserved cis-peptide bond; other site
205922015843	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
205922015844	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
205922015845	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
205922015846	Predicted membrane protein [Function unknown]; Region: COG3766
205922015847	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
205922015848	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
205922015849	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
205922015850	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
205922015851	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
205922015852	dimer interface [polypeptide binding]; other site
205922015853	ssDNA binding site [nucleotide binding]; other site
205922015854	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205922015855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922015856	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922015857	putative substrate translocation pore; other site
205922015858	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
205922015859	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
205922015860	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
205922015861	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
205922015862	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
205922015863	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
205922015864	heme binding site [chemical binding]; other site
205922015865	ferroxidase pore; other site
205922015866	ferroxidase diiron center [ion binding]; other site
205922015867	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
205922015868	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
205922015869	tetramer interface [polypeptide binding]; other site
205922015870	heme binding pocket [chemical binding]; other site
205922015871	NADPH binding site [chemical binding]; other site
205922015872	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
205922015873	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
205922015874	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
205922015875	alphaNTD homodimer interface [polypeptide binding]; other site
205922015876	alphaNTD - beta interaction site [polypeptide binding]; other site
205922015877	alphaNTD - beta' interaction site [polypeptide binding]; other site
205922015878	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
205922015879	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
205922015880	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
205922015881	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
205922015882	RNA binding surface [nucleotide binding]; other site
205922015883	30S ribosomal protein S11; Validated; Region: PRK05309
205922015884	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
205922015885	30S ribosomal protein S13; Region: bact_S13; TIGR03631
205922015886	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
205922015887	SecY translocase; Region: SecY; pfam00344
205922015888	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
205922015889	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
205922015890	23S rRNA binding site [nucleotide binding]; other site
205922015891	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
205922015892	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
205922015893	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
205922015894	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
205922015895	5S rRNA interface [nucleotide binding]; other site
205922015896	23S rRNA interface [nucleotide binding]; other site
205922015897	L5 interface [polypeptide binding]; other site
205922015898	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
205922015899	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
205922015900	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
205922015901	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
205922015902	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
205922015903	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
205922015904	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
205922015905	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
205922015906	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
205922015907	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
205922015908	RNA binding site [nucleotide binding]; other site
205922015909	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
205922015910	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
205922015911	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
205922015912	23S rRNA interface [nucleotide binding]; other site
205922015913	putative translocon interaction site; other site
205922015914	signal recognition particle (SRP54) interaction site; other site
205922015915	L23 interface [polypeptide binding]; other site
205922015916	trigger factor interaction site; other site
205922015917	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
205922015918	23S rRNA interface [nucleotide binding]; other site
205922015919	5S rRNA interface [nucleotide binding]; other site
205922015920	putative antibiotic binding site [chemical binding]; other site
205922015921	L25 interface [polypeptide binding]; other site
205922015922	L27 interface [polypeptide binding]; other site
205922015923	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
205922015924	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
205922015925	G-X-X-G motif; other site
205922015926	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
205922015927	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
205922015928	protein-rRNA interface [nucleotide binding]; other site
205922015929	putative translocon binding site; other site
205922015930	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
205922015931	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
205922015932	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
205922015933	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
205922015934	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
205922015935	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
205922015936	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
205922015937	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
205922015938	elongation factor Tu; Reviewed; Region: PRK00049
205922015939	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
205922015940	G1 box; other site
205922015941	GEF interaction site [polypeptide binding]; other site
205922015942	GTP/Mg2+ binding site [chemical binding]; other site
205922015943	Switch I region; other site
205922015944	G2 box; other site
205922015945	G3 box; other site
205922015946	Switch II region; other site
205922015947	G4 box; other site
205922015948	G5 box; other site
205922015949	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
205922015950	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
205922015951	Antibiotic Binding Site [chemical binding]; other site
205922015952	elongation factor G; Reviewed; Region: PRK00007
205922015953	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
205922015954	G1 box; other site
205922015955	putative GEF interaction site [polypeptide binding]; other site
205922015956	GTP/Mg2+ binding site [chemical binding]; other site
205922015957	Switch I region; other site
205922015958	G2 box; other site
205922015959	G3 box; other site
205922015960	Switch II region; other site
205922015961	G4 box; other site
205922015962	G5 box; other site
205922015963	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
205922015964	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
205922015965	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
205922015966	30S ribosomal protein S7; Validated; Region: PRK05302
205922015967	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
205922015968	S17 interaction site [polypeptide binding]; other site
205922015969	S8 interaction site; other site
205922015970	16S rRNA interaction site [nucleotide binding]; other site
205922015971	streptomycin interaction site [chemical binding]; other site
205922015972	23S rRNA interaction site [nucleotide binding]; other site
205922015973	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
205922015974	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
205922015975	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
205922015976	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
205922015977	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
205922015978	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
205922015979	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
205922015980	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
205922015981	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
205922015982	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
205922015983	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
205922015984	DNA binding site [nucleotide binding]
205922015985	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
205922015986	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
205922015987	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
205922015988	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
205922015989	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
205922015990	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
205922015991	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
205922015992	RPB3 interaction site [polypeptide binding]; other site
205922015993	RPB1 interaction site [polypeptide binding]; other site
205922015994	RPB11 interaction site [polypeptide binding]; other site
205922015995	RPB10 interaction site [polypeptide binding]; other site
205922015996	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
205922015997	core dimer interface [polypeptide binding]; other site
205922015998	peripheral dimer interface [polypeptide binding]; other site
205922015999	L10 interface [polypeptide binding]; other site
205922016000	L11 interface [polypeptide binding]; other site
205922016001	putative EF-Tu interaction site [polypeptide binding]; other site
205922016002	putative EF-G interaction site [polypeptide binding]; other site
205922016003	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
205922016004	23S rRNA interface [nucleotide binding]; other site
205922016005	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
205922016006	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
205922016007	mRNA/rRNA interface [nucleotide binding]; other site
205922016008	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
205922016009	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
205922016010	23S rRNA interface [nucleotide binding]; other site
205922016011	L7/L12 interface [polypeptide binding]; other site
205922016012	putative thiostrepton binding site; other site
205922016013	L25 interface [polypeptide binding]; other site
205922016014	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
205922016015	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
205922016016	putative homodimer interface [polypeptide binding]; other site
205922016017	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
205922016018	heterodimer interface [polypeptide binding]; other site
205922016019	homodimer interface [polypeptide binding]; other site
205922016020	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
205922016021	elongation factor Tu; Reviewed; Region: PRK00049
205922016022	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
205922016023	G1 box; other site
205922016024	GEF interaction site [polypeptide binding]; other site
205922016025	GTP/Mg2+ binding site [chemical binding]; other site
205922016026	Switch I region; other site
205922016027	G2 box; other site
205922016028	G3 box; other site
205922016029	Switch II region; other site
205922016030	G4 box; other site
205922016031	G5 box; other site
205922016032	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
205922016033	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
205922016034	Antibiotic Binding Site [chemical binding]; other site
205922016035	pantothenate kinase; Reviewed; Region: PRK13322
205922016036	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
205922016037	Biotin operon repressor [Transcription]; Region: BirA; COG1654
205922016038	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
205922016039	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
205922016040	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
205922016041	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
205922016042	active site
205922016043	HIGH motif; other site
205922016044	dimer interface [polypeptide binding]; other site
205922016045	KMSKS motif; other site
205922016046	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
205922016047	putative peptidase; Provisional; Region: PRK11649
205922016048	Peptidase family M23; Region: Peptidase_M23; pfam01551
205922016049	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
205922016050	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
205922016051	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
205922016052	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
205922016053	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
205922016054	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
205922016055	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
205922016056	FMN binding site [chemical binding]; other site
205922016057	substrate binding site [chemical binding]; other site
205922016058	putative catalytic residue [active]
205922016059	Protein of unknown function (DUF805); Region: DUF805; pfam05656
205922016060	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
205922016061	classical (c) SDRs; Region: SDR_c; cd05233
205922016062	NAD(P) binding site [chemical binding]; other site
205922016063	active site
205922016064	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
205922016065	nucleotide binding site/active site [active]
205922016066	HIT family signature motif; other site
205922016067	catalytic residue [active]
205922016068	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
205922016069	diiron binding motif [ion binding]; other site
205922016070	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
205922016071	OsmC-like protein; Region: OsmC; cl00767
205922016072	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
205922016073	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
205922016074	ligand binding site [chemical binding]; other site
205922016075	flexible hinge region; other site
205922016076	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
205922016077	putative switch regulator; other site
205922016078	non-specific DNA interactions [nucleotide binding]; other site
205922016079	DNA binding site [nucleotide binding]
205922016080	sequence specific DNA binding site [nucleotide binding]; other site
205922016081	putative cAMP binding site [chemical binding]; other site
205922016082	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
205922016083	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
205922016084	active site
205922016085	ribulose/triose binding site [chemical binding]; other site
205922016086	phosphate binding site [ion binding]; other site
205922016087	substrate (anthranilate) binding pocket [chemical binding]; other site
205922016088	product (indole) binding pocket [chemical binding]; other site
205922016089	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
205922016090	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
205922016091	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
205922016092	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
205922016093	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
205922016094	glutamine binding [chemical binding]; other site
205922016095	catalytic triad [active]
205922016096	phosphoglycolate phosphatase; Provisional; Region: PRK13223
205922016097	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
205922016098	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
205922016099	active site
205922016100	catalytic triad [active]
205922016101	oxyanion hole [active]
205922016102	Autotransporter beta-domain; Region: Autotransporter; pfam03797
205922016103	anthranilate synthase component I; Provisional; Region: PRK13565
205922016104	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
205922016105	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
205922016106	phosphoglycolate phosphatase; Provisional; Region: PRK13223
205922016107	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
205922016108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922016109	motif II; other site
205922016110	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
205922016111	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
205922016112	substrate binding site [chemical binding]; other site
205922016113	hexamer interface [polypeptide binding]; other site
205922016114	metal binding site [ion binding]; metal-binding site
205922016115	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
205922016116	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
205922016117	active site
205922016118	NAD binding site [chemical binding]; other site
205922016119	metal binding site [ion binding]; metal-binding site
205922016120	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922016121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922016122	dimer interface [polypeptide binding]; other site
205922016123	conserved gate region; other site
205922016124	putative PBP binding loops; other site
205922016125	ABC-ATPase subunit interface; other site
205922016126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922016127	dimer interface [polypeptide binding]; other site
205922016128	conserved gate region; other site
205922016129	putative PBP binding loops; other site
205922016130	ABC-ATPase subunit interface; other site
205922016131	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
205922016132	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922016133	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
205922016134	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
205922016135	Walker A/P-loop; other site
205922016136	ATP binding site [chemical binding]; other site
205922016137	Q-loop/lid; other site
205922016138	ABC transporter signature motif; other site
205922016139	Walker B; other site
205922016140	D-loop; other site
205922016141	H-loop/switch region; other site
205922016142	TOBE domain; Region: TOBE_2; pfam08402
205922016143	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
205922016144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016145	active site
205922016146	phosphorylation site [posttranslational modification]
205922016147	intermolecular recognition site; other site
205922016148	dimerization interface [polypeptide binding]; other site
205922016149	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922016150	DNA binding residues [nucleotide binding]
205922016151	dimerization interface [polypeptide binding]; other site
205922016152	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922016153	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922016154	substrate binding pocket [chemical binding]; other site
205922016155	membrane-bound complex binding site; other site
205922016156	hinge residues; other site
205922016157	PAS domain; Region: PAS_9; pfam13426
205922016158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922016159	putative active site [active]
205922016160	heme pocket [chemical binding]; other site
205922016161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922016162	PAS fold; Region: PAS_3; pfam08447
205922016163	putative active site [active]
205922016164	heme pocket [chemical binding]; other site
205922016165	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
205922016166	Histidine kinase; Region: HisKA_3; pfam07730
205922016167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922016168	ATP binding site [chemical binding]; other site
205922016169	Mg2+ binding site [ion binding]; other site
205922016170	G-X-G motif; other site
205922016171	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
205922016172	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
205922016173	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
205922016174	putative metal binding site [ion binding]; other site
205922016175	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
205922016176	HSP70 interaction site [polypeptide binding]; other site
205922016177	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
205922016178	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
205922016179	Substrate binding site; other site
205922016180	metal-binding site
205922016181	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
205922016182	Phosphotransferase enzyme family; Region: APH; pfam01636
205922016183	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
205922016184	OstA-like protein; Region: OstA; cl00844
205922016185	Organic solvent tolerance protein; Region: OstA_C; pfam04453
205922016186	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
205922016187	SurA N-terminal domain; Region: SurA_N; pfam09312
205922016188	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
205922016189	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
205922016190	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
205922016191	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
205922016192	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
205922016193	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
205922016194	S-adenosylmethionine binding site [chemical binding]; other site
205922016195	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
205922016196	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
205922016197	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
205922016198	active site
205922016199	metal binding site [ion binding]; metal-binding site
205922016200	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
205922016201	active site residue [active]
205922016202	PrkA family serine protein kinase; Provisional; Region: PRK15455
205922016203	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
205922016204	hypothetical protein; Provisional; Region: PRK05325
205922016205	SpoVR family protein; Provisional; Region: PRK11767
205922016206	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
205922016207	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
205922016208	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
205922016209	active site
205922016210	NTP binding site [chemical binding]; other site
205922016211	metal binding triad [ion binding]; metal-binding site
205922016212	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
205922016213	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922016214	Zn2+ binding site [ion binding]; other site
205922016215	Mg2+ binding site [ion binding]; other site
205922016216	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
205922016217	catalytic center binding site [active]
205922016218	ATP binding site [chemical binding]; other site
205922016219	Dihydroneopterin aldolase; Region: FolB; smart00905
205922016220	active site
205922016221	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
205922016222	UGMP family protein; Validated; Region: PRK09604
205922016223	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
205922016224	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
205922016225	DNA primase, catalytic core; Region: dnaG; TIGR01391
205922016226	CHC2 zinc finger; Region: zf-CHC2; pfam01807
205922016227	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
205922016228	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
205922016229	active site
205922016230	metal binding site [ion binding]; metal-binding site
205922016231	interdomain interaction site; other site
205922016232	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
205922016233	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
205922016234	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
205922016235	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
205922016236	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
205922016237	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
205922016238	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922016239	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
205922016240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922016241	DNA binding residues [nucleotide binding]
205922016242	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922016243	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922016244	substrate binding pocket [chemical binding]; other site
205922016245	membrane-bound complex binding site; other site
205922016246	hinge residues; other site
205922016247	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922016248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922016249	putative active site [active]
205922016250	heme pocket [chemical binding]; other site
205922016251	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922016252	putative active site [active]
205922016253	heme pocket [chemical binding]; other site
205922016254	PAS domain S-box; Region: sensory_box; TIGR00229
205922016255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922016256	PAS domain; Region: PAS_9; pfam13426
205922016257	putative active site [active]
205922016258	heme pocket [chemical binding]; other site
205922016259	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922016260	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922016261	metal binding site [ion binding]; metal-binding site
205922016262	active site
205922016263	I-site; other site
205922016264	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922016265	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
205922016266	ThiF family; Region: ThiF; pfam00899
205922016267	ATP binding site [chemical binding]; other site
205922016268	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
205922016269	nucleotide binding site/active site [active]
205922016270	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
205922016271	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922016272	putative DNA binding site [nucleotide binding]; other site
205922016273	putative Zn2+ binding site [ion binding]; other site
205922016274	AsnC family; Region: AsnC_trans_reg; pfam01037
205922016275	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
205922016276	Predicted amidohydrolase [General function prediction only]; Region: COG0388
205922016277	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
205922016278	putative active site [active]
205922016279	catalytic triad [active]
205922016280	putative dimer interface [polypeptide binding]; other site
205922016281	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
205922016282	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
205922016283	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205922016284	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205922016285	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
205922016286	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
205922016287	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
205922016288	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
205922016289	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
205922016290	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
205922016291	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922016292	FeS/SAM binding site; other site
205922016293	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
205922016294	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
205922016295	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
205922016296	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
205922016297	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
205922016298	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922016299	inhibitor-cofactor binding pocket; inhibition site
205922016300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922016301	catalytic residue [active]
205922016302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922016303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922016304	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922016305	dimerization interface [polypeptide binding]; other site
205922016306	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
205922016307	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
205922016308	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922016309	active site
205922016310	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
205922016311	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
205922016312	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
205922016313	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
205922016314	FAD binding site [chemical binding]; other site
205922016315	substrate binding site [chemical binding]; other site
205922016316	catalytic residues [active]
205922016317	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
205922016318	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922016319	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922016320	metal binding site [ion binding]; metal-binding site
205922016321	active site
205922016322	I-site; other site
205922016323	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
205922016324	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
205922016325	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
205922016326	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
205922016327	active site
205922016328	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
205922016329	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
205922016330	AAA domain; Region: AAA_26; pfam13500
205922016331	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
205922016332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922016333	S-adenosylmethionine binding site [chemical binding]; other site
205922016334	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
205922016335	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
205922016336	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
205922016337	substrate-cofactor binding pocket; other site
205922016338	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922016339	catalytic residue [active]
205922016340	biotin synthase; Provisional; Region: PRK15108
205922016341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922016342	FeS/SAM binding site; other site
205922016343	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
205922016344	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
205922016345	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922016346	active site
205922016347	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
205922016348	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
205922016349	TOBE domain; Region: TOBE; cl01440
205922016350	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
205922016351	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
205922016352	serine/threonine protein kinase; Provisional; Region: PRK11768
205922016353	Predicted permeases [General function prediction only]; Region: RarD; COG2962
205922016354	EamA-like transporter family; Region: EamA; pfam00892
205922016355	EamA-like transporter family; Region: EamA; cl17759
205922016356	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
205922016357	ACT domain; Region: ACT_6; pfam13740
205922016358	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
205922016359	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
205922016360	active site
205922016361	Response regulator receiver domain; Region: Response_reg; pfam00072
205922016362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016363	active site
205922016364	phosphorylation site [posttranslational modification]
205922016365	intermolecular recognition site; other site
205922016366	dimerization interface [polypeptide binding]; other site
205922016367	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
205922016368	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
205922016369	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
205922016370	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
205922016371	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
205922016372	metal binding triad; other site
205922016373	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
205922016374	active site
205922016375	catalytic site [active]
205922016376	substrate binding site [chemical binding]; other site
205922016377	RNA polymerase sigma factor; Reviewed; Region: PRK12523
205922016378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922016379	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922016380	DNA binding residues [nucleotide binding]
205922016381	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
205922016382	FecR protein; Region: FecR; pfam04773
205922016383	Secretin and TonB N terminus short domain; Region: STN; smart00965
205922016384	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
205922016385	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
205922016386	N-terminal plug; other site
205922016387	ligand-binding site [chemical binding]; other site
205922016388	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
205922016389	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
205922016390	putative glutathione S-transferase; Provisional; Region: PRK10357
205922016391	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
205922016392	putative C-terminal domain interface [polypeptide binding]; other site
205922016393	putative GSH binding site (G-site) [chemical binding]; other site
205922016394	putative dimer interface [polypeptide binding]; other site
205922016395	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
205922016396	dimer interface [polypeptide binding]; other site
205922016397	N-terminal domain interface [polypeptide binding]; other site
205922016398	putative substrate binding pocket (H-site) [chemical binding]; other site
205922016399	inner membrane protein; Provisional; Region: PRK11715
205922016400	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922016401	sensory histidine kinase CreC; Provisional; Region: PRK11100
205922016402	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922016403	dimerization interface [polypeptide binding]; other site
205922016404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922016405	dimer interface [polypeptide binding]; other site
205922016406	phosphorylation site [posttranslational modification]
205922016407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922016408	ATP binding site [chemical binding]; other site
205922016409	Mg2+ binding site [ion binding]; other site
205922016410	G-X-G motif; other site
205922016411	DNA-binding response regulator CreB; Provisional; Region: PRK11083
205922016412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016413	active site
205922016414	phosphorylation site [posttranslational modification]
205922016415	intermolecular recognition site; other site
205922016416	dimerization interface [polypeptide binding]; other site
205922016417	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922016418	DNA binding site [nucleotide binding]
205922016419	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
205922016420	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
205922016421	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
205922016422	putative acyl-acceptor binding pocket; other site
205922016423	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
205922016424	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922016425	Anti-sigma-K factor rskA; Region: RskA; pfam10099
205922016426	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
205922016427	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
205922016428	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
205922016429	NAD binding site [chemical binding]; other site
205922016430	catalytic Zn binding site [ion binding]; other site
205922016431	structural Zn binding site [ion binding]; other site
205922016432	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
205922016433	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
205922016434	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
205922016435	putative active site [active]
205922016436	putative substrate binding site [chemical binding]; other site
205922016437	putative cosubstrate binding site; other site
205922016438	catalytic site [active]
205922016439	Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268
205922016440	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
205922016441	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
205922016442	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
205922016443	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
205922016444	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
205922016445	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922016446	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
205922016447	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
205922016448	dimer interface [polypeptide binding]; other site
205922016449	active site
205922016450	glycine-pyridoxal phosphate binding site [chemical binding]; other site
205922016451	folate binding site [chemical binding]; other site
205922016452	TraX protein; Region: TraX; cl05434
205922016453	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
205922016454	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
205922016455	tetramer interface [polypeptide binding]; other site
205922016456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922016457	catalytic residue [active]
205922016458	short chain dehydrogenase; Provisional; Region: PRK08278
205922016459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922016460	NAD(P) binding site [chemical binding]; other site
205922016461	active site
205922016462	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
205922016463	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
205922016464	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
205922016465	FAD binding pocket [chemical binding]; other site
205922016466	FAD binding motif [chemical binding]; other site
205922016467	phosphate binding motif [ion binding]; other site
205922016468	beta-alpha-beta structure motif; other site
205922016469	NAD binding pocket [chemical binding]; other site
205922016470	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922016471	catalytic loop [active]
205922016472	iron binding site [ion binding]; other site
205922016473	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
205922016474	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
205922016475	[2Fe-2S] cluster binding site [ion binding]; other site
205922016476	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
205922016477	putative alpha subunit interface [polypeptide binding]; other site
205922016478	putative active site [active]
205922016479	putative substrate binding site [chemical binding]; other site
205922016480	Fe binding site [ion binding]; other site
205922016481	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
205922016482	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
205922016483	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922016484	triacylglycerol lipase; Region: PLN02872
205922016485	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
205922016486	Electron transfer flavoprotein domain; Region: ETF; pfam01012
205922016487	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
205922016488	Ligand binding site [chemical binding]; other site
205922016489	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
205922016490	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
205922016491	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
205922016492	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
205922016493	Cysteine-rich domain; Region: CCG; pfam02754
205922016494	Cysteine-rich domain; Region: CCG; pfam02754
205922016495	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
205922016496	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
205922016497	putative active site [active]
205922016498	putative FMN binding site [chemical binding]; other site
205922016499	putative substrate binding site [chemical binding]; other site
205922016500	putative catalytic residue [active]
205922016501	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922016502	V4R domain; Region: V4R; cl15268
205922016503	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
205922016504	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
205922016505	active site
205922016506	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
205922016507	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
205922016508	Archaeal ATPase; Region: Arch_ATPase; pfam01637
205922016509	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922016510	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
205922016511	conserved cys residue [active]
205922016512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922016513	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922016514	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
205922016515	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
205922016516	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
205922016517	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922016518	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
205922016519	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
205922016520	active site
205922016521	Protein of unknown function (DUF971); Region: DUF971; cl01414
205922016522	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
205922016523	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
205922016524	substrate binding pocket [chemical binding]; other site
205922016525	active site
205922016526	iron coordination sites [ion binding]; other site
205922016527	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922016528	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
205922016529	conserved cys residue [active]
205922016530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922016531	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
205922016532	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
205922016533	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
205922016534	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
205922016535	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
205922016536	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922016537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922016538	dimer interface [polypeptide binding]; other site
205922016539	conserved gate region; other site
205922016540	putative PBP binding loops; other site
205922016541	ABC-ATPase subunit interface; other site
205922016542	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
205922016543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922016544	Walker A/P-loop; other site
205922016545	ATP binding site [chemical binding]; other site
205922016546	Q-loop/lid; other site
205922016547	ABC transporter signature motif; other site
205922016548	Walker B; other site
205922016549	D-loop; other site
205922016550	H-loop/switch region; other site
205922016551	BCCT family transporter; Region: BCCT; cl00569
205922016552	transcriptional regulator BetI; Validated; Region: PRK00767
205922016553	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922016554	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
205922016555	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
205922016556	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
205922016557	tetrameric interface [polypeptide binding]; other site
205922016558	NAD binding site [chemical binding]; other site
205922016559	catalytic residues [active]
205922016560	choline dehydrogenase; Validated; Region: PRK02106
205922016561	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922016562	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
205922016563	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
205922016564	peptidase PmbA; Provisional; Region: PRK11040
205922016565	putative transporter; Provisional; Region: PRK10504
205922016566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922016567	putative substrate translocation pore; other site
205922016568	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
205922016569	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205922016570	ATP binding site [chemical binding]; other site
205922016571	Mg++ binding site [ion binding]; other site
205922016572	motif III; other site
205922016573	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922016574	nucleotide binding region [chemical binding]; other site
205922016575	ATP-binding site [chemical binding]; other site
205922016576	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
205922016577	putative RNA binding site [nucleotide binding]; other site
205922016578	HI0933-like protein; Region: HI0933_like; pfam03486
205922016579	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
205922016580	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
205922016581	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
205922016582	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
205922016583	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922016584	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922016585	substrate binding pocket [chemical binding]; other site
205922016586	membrane-bound complex binding site; other site
205922016587	hinge residues; other site
205922016588	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
205922016589	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922016590	Coenzyme A binding pocket [chemical binding]; other site
205922016591	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
205922016592	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
205922016593	Response regulator receiver domain; Region: Response_reg; pfam00072
205922016594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016595	active site
205922016596	phosphorylation site [posttranslational modification]
205922016597	intermolecular recognition site; other site
205922016598	dimerization interface [polypeptide binding]; other site
205922016599	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922016600	PAS domain; Region: PAS_9; pfam13426
205922016601	putative active site [active]
205922016602	heme pocket [chemical binding]; other site
205922016603	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922016604	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922016605	metal binding site [ion binding]; metal-binding site
205922016606	active site
205922016607	I-site; other site
205922016608	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922016609	Alginate lyase; Region: Alginate_lyase2; pfam08787
205922016610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922016611	non-specific DNA binding site [nucleotide binding]; other site
205922016612	salt bridge; other site
205922016613	sequence-specific DNA binding site [nucleotide binding]; other site
205922016614	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
205922016615	zinc binding site [ion binding]; other site
205922016616	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
205922016617	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
205922016618	intersubunit interface [polypeptide binding]; other site
205922016619	active site
205922016620	zinc binding site [ion binding]; other site
205922016621	Na+ binding site [ion binding]; other site
205922016622	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
205922016623	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
205922016624	Phosphoglycerate kinase; Region: PGK; pfam00162
205922016625	substrate binding site [chemical binding]; other site
205922016626	hinge regions; other site
205922016627	ADP binding site [chemical binding]; other site
205922016628	catalytic site [active]
205922016629	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
205922016630	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
205922016631	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
205922016632	transketolase; Reviewed; Region: PRK12753
205922016633	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
205922016634	TPP-binding site [chemical binding]; other site
205922016635	dimer interface [polypeptide binding]; other site
205922016636	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
205922016637	PYR/PP interface [polypeptide binding]; other site
205922016638	dimer interface [polypeptide binding]; other site
205922016639	TPP binding site [chemical binding]; other site
205922016640	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
205922016641	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922016642	putative DNA binding site [nucleotide binding]; other site
205922016643	putative Zn2+ binding site [ion binding]; other site
205922016644	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922016645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922016646	S-adenosylmethionine binding site [chemical binding]; other site
205922016647	S-adenosylmethionine synthetase; Validated; Region: PRK05250
205922016648	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
205922016649	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
205922016650	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
205922016651	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
205922016652	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
205922016653	nucleotide binding pocket [chemical binding]; other site
205922016654	K-X-D-G motif; other site
205922016655	catalytic site [active]
205922016656	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
205922016657	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
205922016658	Cytochrome C' Region: Cytochrom_C_2; pfam01322
205922016659	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
205922016660	MltA specific insert domain; Region: MltA; smart00925
205922016661	3D domain; Region: 3D; pfam06725
205922016662	Predicted membrane protein [Function unknown]; Region: COG3686
205922016663	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
205922016664	EamA-like transporter family; Region: EamA; pfam00892
205922016665	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
205922016666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922016667	putative substrate translocation pore; other site
205922016668	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
205922016669	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
205922016670	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
205922016671	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
205922016672	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
205922016673	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
205922016674	homotetramer interface [polypeptide binding]; other site
205922016675	ligand binding site [chemical binding]; other site
205922016676	catalytic site [active]
205922016677	NAD binding site [chemical binding]; other site
205922016678	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
205922016679	FAD binding site [chemical binding]; other site
205922016680	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922016681	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922016682	substrate binding pocket [chemical binding]; other site
205922016683	membrane-bound complex binding site; other site
205922016684	hinge residues; other site
205922016685	helicase 45; Provisional; Region: PTZ00424
205922016686	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
205922016687	ATP binding site [chemical binding]; other site
205922016688	Mg++ binding site [ion binding]; other site
205922016689	motif III; other site
205922016690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922016691	nucleotide binding region [chemical binding]; other site
205922016692	ATP-binding site [chemical binding]; other site
205922016693	hypothetical protein; Provisional; Region: PRK03757
205922016694	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
205922016695	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
205922016696	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
205922016697	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
205922016698	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922016699	inhibitor-cofactor binding pocket; inhibition site
205922016700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922016701	catalytic residue [active]
205922016702	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
205922016703	RNA methyltransferase, RsmE family; Region: TIGR00046
205922016704	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
205922016705	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922016706	substrate binding pocket [chemical binding]; other site
205922016707	membrane-bound complex binding site; other site
205922016708	hinge residues; other site
205922016709	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922016710	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
205922016711	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922016712	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
205922016713	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922016714	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
205922016715	dimerization interface [polypeptide binding]; other site
205922016716	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
205922016717	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
205922016718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922016719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922016720	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
205922016721	putative dimerization interface [polypeptide binding]; other site
205922016722	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
205922016723	Malonate transporter MadL subunit; Region: MadL; pfam03817
205922016724	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
205922016725	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
205922016726	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
205922016727	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
205922016728	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
205922016729	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
205922016730	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
205922016731	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
205922016732	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
205922016733	CheW-like domain; Region: CheW; pfam01584
205922016734	Hpt domain; Region: Hpt; pfam01627
205922016735	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922016736	putative binding surface; other site
205922016737	active site
205922016738	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922016739	putative binding surface; other site
205922016740	active site
205922016741	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
205922016742	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922016743	putative binding surface; other site
205922016744	active site
205922016745	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
205922016746	putative binding surface; other site
205922016747	active site
205922016748	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
205922016749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922016750	ATP binding site [chemical binding]; other site
205922016751	Mg2+ binding site [ion binding]; other site
205922016752	G-X-G motif; other site
205922016753	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
205922016754	Response regulator receiver domain; Region: Response_reg; pfam00072
205922016755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016756	active site
205922016757	phosphorylation site [posttranslational modification]
205922016758	intermolecular recognition site; other site
205922016759	dimerization interface [polypeptide binding]; other site
205922016760	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
205922016761	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
205922016762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922016763	dimer interface [polypeptide binding]; other site
205922016764	putative CheW interface [polypeptide binding]; other site
205922016765	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
205922016766	Response regulator receiver domain; Region: Response_reg; pfam00072
205922016767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016768	active site
205922016769	phosphorylation site [posttranslational modification]
205922016770	intermolecular recognition site; other site
205922016771	dimerization interface [polypeptide binding]; other site
205922016772	Response regulator receiver domain; Region: Response_reg; pfam00072
205922016773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922016774	active site
205922016775	phosphorylation site [posttranslational modification]
205922016776	intermolecular recognition site; other site
205922016777	dimerization interface [polypeptide binding]; other site
205922016778	glutathione synthetase; Provisional; Region: PRK05246
205922016779	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
205922016780	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
205922016781	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
205922016782	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
205922016783	hypothetical protein; Validated; Region: PRK00228
205922016784	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
205922016785	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
205922016786	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922016787	active site
205922016788	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
205922016789	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
205922016790	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
205922016791	dihydroorotase; Validated; Region: pyrC; PRK09357
205922016792	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922016793	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
205922016794	active site
205922016795	TM2 domain; Region: TM2; cl00984
205922016796	TM2 domain; Region: TM2; cl00984
205922016797	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
205922016798	NlpC/P60 family; Region: NLPC_P60; pfam00877
205922016799	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
205922016800	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
205922016801	Walker A motif; other site
205922016802	ATP binding site [chemical binding]; other site
205922016803	Walker B motif; other site
205922016804	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
205922016805	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922016806	catalytic residue [active]
205922016807	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
205922016808	pyrroline-5-carboxylate reductase; Region: PLN02688
205922016809	YGGT family; Region: YGGT; pfam02325
205922016810	YGGT family; Region: YGGT; pfam02325
205922016811	hypothetical protein; Validated; Region: PRK05090
205922016812	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
205922016813	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
205922016814	Methyltransferase domain; Region: Methyltransf_23; pfam13489
205922016815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922016816	S-adenosylmethionine binding site [chemical binding]; other site
205922016817	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
205922016818	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
205922016819	active site
205922016820	dimerization interface [polypeptide binding]; other site
205922016821	HemN family oxidoreductase; Provisional; Region: PRK05660
205922016822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
205922016823	FeS/SAM binding site; other site
205922016824	HemN C-terminal domain; Region: HemN_C; pfam06969
205922016825	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
205922016826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922016827	S-adenosylmethionine binding site [chemical binding]; other site
205922016828	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
205922016829	ThiS interaction site; other site
205922016830	putative active site [active]
205922016831	tetramer interface [polypeptide binding]; other site
205922016832	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
205922016833	thiS-thiF/thiG interaction site; other site
205922016834	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
205922016835	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
205922016836	Transglycosylase; Region: Transgly; cl17702
205922016837	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
205922016838	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
205922016839	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922016840	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
205922016841	DNA binding residues [nucleotide binding]
205922016842	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
205922016843	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
205922016844	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
205922016845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922016846	Walker A/P-loop; other site
205922016847	ATP binding site [chemical binding]; other site
205922016848	Q-loop/lid; other site
205922016849	ABC transporter signature motif; other site
205922016850	Walker B; other site
205922016851	D-loop; other site
205922016852	H-loop/switch region; other site
205922016853	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
205922016854	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
205922016855	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
205922016856	P loop; other site
205922016857	GTP binding site [chemical binding]; other site
205922016858	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
205922016859	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
205922016860	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205922016861	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
205922016862	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
205922016863	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
205922016864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922016865	S-adenosylmethionine binding site [chemical binding]; other site
205922016866	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
205922016867	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
205922016868	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922016869	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922016870	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922016871	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
205922016872	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
205922016873	active site residue [active]
205922016874	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
205922016875	active site residue [active]
205922016876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922016877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922016878	Bacterial transcriptional repressor; Region: TetR; pfam13972
205922016879	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
205922016880	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
205922016881	NAD(P) binding site [chemical binding]; other site
205922016882	catalytic residues [active]
205922016883	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
205922016884	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
205922016885	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
205922016886	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
205922016887	active site
205922016888	(T/H)XGH motif; other site
205922016889	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
205922016890	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
205922016891	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
205922016892	DNA binding site [nucleotide binding]
205922016893	catalytic residue [active]
205922016894	H2TH interface [polypeptide binding]; other site
205922016895	putative catalytic residues [active]
205922016896	turnover-facilitating residue; other site
205922016897	intercalation triad [nucleotide binding]; other site
205922016898	8OG recognition residue [nucleotide binding]; other site
205922016899	putative reading head residues; other site
205922016900	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
205922016901	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
205922016902	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
205922016903	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
205922016904	intracellular protease, PfpI family; Region: PfpI; TIGR01382
205922016905	proposed catalytic triad [active]
205922016906	conserved cys residue [active]
205922016907	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
205922016908	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
205922016909	putative RNA binding site [nucleotide binding]; other site
205922016910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922016911	S-adenosylmethionine binding site [chemical binding]; other site
205922016912	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
205922016913	putative FMN binding site [chemical binding]; other site
205922016914	NADPH bind site [chemical binding]; other site
205922016915	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
205922016916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922016917	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
205922016918	putative substrate translocation pore; other site
205922016919	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
205922016920	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
205922016921	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
205922016922	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
205922016923	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
205922016924	folate binding site [chemical binding]; other site
205922016925	NADP+ binding site [chemical binding]; other site
205922016926	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
205922016927	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
205922016928	G1 box; other site
205922016929	GTP/Mg2+ binding site [chemical binding]; other site
205922016930	G2 box; other site
205922016931	Switch I region; other site
205922016932	G3 box; other site
205922016933	Switch II region; other site
205922016934	G4 box; other site
205922016935	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
205922016936	G5 box; other site
205922016937	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922016938	Zn2+ binding site [ion binding]; other site
205922016939	Mg2+ binding site [ion binding]; other site
205922016940	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
205922016941	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922016942	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
205922016943	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922016944	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
205922016945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922016946	dimer interface [polypeptide binding]; other site
205922016947	conserved gate region; other site
205922016948	putative PBP binding loops; other site
205922016949	ABC-ATPase subunit interface; other site
205922016950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922016951	dimer interface [polypeptide binding]; other site
205922016952	conserved gate region; other site
205922016953	putative PBP binding loops; other site
205922016954	ABC-ATPase subunit interface; other site
205922016955	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
205922016956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922016957	Walker A/P-loop; other site
205922016958	ATP binding site [chemical binding]; other site
205922016959	Q-loop/lid; other site
205922016960	ABC transporter signature motif; other site
205922016961	Walker B; other site
205922016962	D-loop; other site
205922016963	H-loop/switch region; other site
205922016964	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
205922016965	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922016966	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922016967	dimerization interface [polypeptide binding]; other site
205922016968	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
205922016969	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
205922016970	metal-binding site [ion binding]
205922016971	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205922016972	Soluble P-type ATPase [General function prediction only]; Region: COG4087
205922016973	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
205922016974	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
205922016975	DNA binding residues [nucleotide binding]
205922016976	dimer interface [polypeptide binding]; other site
205922016977	putative metal binding site [ion binding]; other site
205922016978	thymidylate synthase; Provisional; Region: thyA; PRK13821
205922016979	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
205922016980	dimerization interface [polypeptide binding]; other site
205922016981	active site
205922016982	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
205922016983	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
205922016984	NRDE protein; Region: NRDE; cl01315
205922016985	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
205922016986	GAF domain; Region: GAF; pfam01590
205922016987	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
205922016988	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205922016989	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
205922016990	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
205922016991	putative active site [active]
205922016992	Ap4A binding site [chemical binding]; other site
205922016993	nudix motif; other site
205922016994	putative metal binding site [ion binding]; other site
205922016995	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
205922016996	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922016997	motif II; other site
205922016998	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
205922016999	threonine dehydratase; Reviewed; Region: PRK09224
205922017000	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
205922017001	tetramer interface [polypeptide binding]; other site
205922017002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922017003	catalytic residue [active]
205922017004	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
205922017005	putative Ile/Val binding site [chemical binding]; other site
205922017006	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
205922017007	putative Ile/Val binding site [chemical binding]; other site
205922017008	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
205922017009	tetramer (dimer of dimers) interface [polypeptide binding]; other site
205922017010	active site
205922017011	dimer interface [polypeptide binding]; other site
205922017012	SdiA-regulated; Region: SdiA-regulated; pfam06977
205922017013	SdiA-regulated; Region: SdiA-regulated; cd09971
205922017014	putative active site [active]
205922017015	SdiA-regulated; Region: SdiA-regulated; pfam06977
205922017016	SdiA-regulated; Region: SdiA-regulated; cd09971
205922017017	putative active site [active]
205922017018	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
205922017019	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
205922017020	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
205922017021	FAD binding domain; Region: FAD_binding_4; pfam01565
205922017022	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
205922017023	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
205922017024	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
205922017025	ligand binding site [chemical binding]; other site
205922017026	NAD binding site [chemical binding]; other site
205922017027	tetramer interface [polypeptide binding]; other site
205922017028	catalytic site [active]
205922017029	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
205922017030	L-serine binding site [chemical binding]; other site
205922017031	ACT domain interface; other site
205922017032	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
205922017033	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922017034	substrate binding pocket [chemical binding]; other site
205922017035	Uncharacterized conserved protein [Function unknown]; Region: COG1683
205922017036	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
205922017037	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
205922017038	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
205922017039	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
205922017040	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
205922017041	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
205922017042	S-type Pyocin; Region: Pyocin_S; pfam06958
205922017043	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
205922017044	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
205922017045	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
205922017046	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
205922017047	active site
205922017048	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
205922017049	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
205922017050	conserved cys residue [active]
205922017051	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922017052	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922017053	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
205922017054	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922017055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017056	dimer interface [polypeptide binding]; other site
205922017057	conserved gate region; other site
205922017058	putative PBP binding loops; other site
205922017059	ABC-ATPase subunit interface; other site
205922017060	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
205922017061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017062	dimer interface [polypeptide binding]; other site
205922017063	conserved gate region; other site
205922017064	putative PBP binding loops; other site
205922017065	ABC-ATPase subunit interface; other site
205922017066	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
205922017067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922017068	Walker A/P-loop; other site
205922017069	ATP binding site [chemical binding]; other site
205922017070	Q-loop/lid; other site
205922017071	ABC transporter signature motif; other site
205922017072	Walker B; other site
205922017073	D-loop; other site
205922017074	H-loop/switch region; other site
205922017075	TOBE domain; Region: TOBE_2; pfam08402
205922017076	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922017077	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922017078	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922017079	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922017080	putative aminotransferase; Validated; Region: PRK07480
205922017081	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
205922017082	inhibitor-cofactor binding pocket; inhibition site
205922017083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922017084	catalytic residue [active]
205922017085	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922017086	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922017087	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
205922017088	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
205922017089	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
205922017090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
205922017091	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
205922017092	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
205922017093	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
205922017094	Walker A/P-loop; other site
205922017095	ATP binding site [chemical binding]; other site
205922017096	Q-loop/lid; other site
205922017097	ABC transporter signature motif; other site
205922017098	Walker B; other site
205922017099	D-loop; other site
205922017100	H-loop/switch region; other site
205922017101	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
205922017102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017103	dimer interface [polypeptide binding]; other site
205922017104	conserved gate region; other site
205922017105	putative PBP binding loops; other site
205922017106	ABC-ATPase subunit interface; other site
205922017107	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
205922017108	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
205922017109	active site
205922017110	dimer interface [polypeptide binding]; other site
205922017111	non-prolyl cis peptide bond; other site
205922017112	insertion regions; other site
205922017113	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
205922017114	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922017115	substrate binding pocket [chemical binding]; other site
205922017116	membrane-bound complex binding site; other site
205922017117	hinge residues; other site
205922017118	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
205922017119	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
205922017120	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
205922017121	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
205922017122	dimer interface [polypeptide binding]; other site
205922017123	decamer (pentamer of dimers) interface [polypeptide binding]; other site
205922017124	catalytic triad [active]
205922017125	outer membrane porin, OprD family; Region: OprD; pfam03573
205922017126	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
205922017127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922017128	substrate binding pocket [chemical binding]; other site
205922017129	membrane-bound complex binding site; other site
205922017130	hinge residues; other site
205922017131	N-acetylglutamate synthase; Validated; Region: PRK05279
205922017132	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
205922017133	putative feedback inhibition sensing region; other site
205922017134	putative nucleotide binding site [chemical binding]; other site
205922017135	putative substrate binding site [chemical binding]; other site
205922017136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922017137	Coenzyme A binding pocket [chemical binding]; other site
205922017138	acetylornithine deacetylase; Provisional; Region: PRK05111
205922017139	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
205922017140	metal binding site [ion binding]; metal-binding site
205922017141	putative dimer interface [polypeptide binding]; other site
205922017142	Uncharacterized conserved protein [Function unknown]; Region: COG3025
205922017143	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
205922017144	putative active site [active]
205922017145	putative metal binding residues [ion binding]; other site
205922017146	signature motif; other site
205922017147	putative triphosphate binding site [ion binding]; other site
205922017148	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
205922017149	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922017150	putative DNA binding site [nucleotide binding]; other site
205922017151	putative Zn2+ binding site [ion binding]; other site
205922017152	AsnC family; Region: AsnC_trans_reg; pfam01037
205922017153	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
205922017154	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
205922017155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
205922017156	Walker A motif; other site
205922017157	ATP binding site [chemical binding]; other site
205922017158	Walker B motif; other site
205922017159	conserverd hypothetical protein; Region: TIGR02448
205922017160	glycine dehydrogenase; Provisional; Region: PRK12566
205922017161	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
205922017162	tetramer interface [polypeptide binding]; other site
205922017163	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922017164	catalytic residue [active]
205922017165	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
205922017166	tetramer interface [polypeptide binding]; other site
205922017167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922017168	catalytic residue [active]
205922017169	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
205922017170	lipoyl attachment site [posttranslational modification]; other site
205922017171	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
205922017172	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
205922017173	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
205922017174	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017175	dimer interface [polypeptide binding]; other site
205922017176	conserved gate region; other site
205922017177	putative PBP binding loops; other site
205922017178	ABC-ATPase subunit interface; other site
205922017179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017180	dimer interface [polypeptide binding]; other site
205922017181	conserved gate region; other site
205922017182	putative PBP binding loops; other site
205922017183	ABC-ATPase subunit interface; other site
205922017184	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
205922017185	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
205922017186	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
205922017187	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
205922017188	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
205922017189	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
205922017190	proline aminopeptidase P II; Provisional; Region: PRK10879
205922017191	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
205922017192	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
205922017193	active site
205922017194	hypothetical protein; Reviewed; Region: PRK02166
205922017195	TIGR02449 family protein; Region: TIGR02449
205922017196	Cell division protein ZapA; Region: ZapA; pfam05164
205922017197	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
205922017198	EVE domain; Region: EVE; cl00728
205922017199	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
205922017200	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
205922017201	HlyD family secretion protein; Region: HlyD_3; pfam13437
205922017202	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205922017203	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
205922017204	Walker A/P-loop; other site
205922017205	ATP binding site [chemical binding]; other site
205922017206	Q-loop/lid; other site
205922017207	ABC transporter signature motif; other site
205922017208	Walker B; other site
205922017209	D-loop; other site
205922017210	H-loop/switch region; other site
205922017211	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
205922017212	Walker A/P-loop; other site
205922017213	ATP binding site [chemical binding]; other site
205922017214	Q-loop/lid; other site
205922017215	ABC transporter signature motif; other site
205922017216	Walker B; other site
205922017217	D-loop; other site
205922017218	H-loop/switch region; other site
205922017219	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
205922017220	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
205922017221	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
205922017222	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
205922017223	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
205922017224	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
205922017225	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
205922017226	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
205922017227	NAD(P) binding site [chemical binding]; other site
205922017228	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
205922017229	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
205922017230	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
205922017231	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
205922017232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922017233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922017234	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
205922017235	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
205922017236	putative active site pocket [active]
205922017237	dimerization interface [polypeptide binding]; other site
205922017238	putative catalytic residue [active]
205922017239	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
205922017240	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922017241	catalytic loop [active]
205922017242	iron binding site [ion binding]; other site
205922017243	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
205922017244	FAD binding pocket [chemical binding]; other site
205922017245	FAD binding motif [chemical binding]; other site
205922017246	phosphate binding motif [ion binding]; other site
205922017247	beta-alpha-beta structure motif; other site
205922017248	NAD binding pocket [chemical binding]; other site
205922017249	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
205922017250	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922017251	transcription termination factor Rho; Provisional; Region: rho; PRK09376
205922017252	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
205922017253	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
205922017254	RNA binding site [nucleotide binding]; other site
205922017255	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
205922017256	multimer interface [polypeptide binding]; other site
205922017257	Walker A motif; other site
205922017258	ATP binding site [chemical binding]; other site
205922017259	Walker B motif; other site
205922017260	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
205922017261	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205922017262	catalytic residues [active]
205922017263	Transcriptional regulators [Transcription]; Region: FadR; COG2186
205922017264	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922017265	DNA-binding site [nucleotide binding]; DNA binding site
205922017266	FCD domain; Region: FCD; pfam07729
205922017267	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
205922017268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
205922017269	substrate binding pocket [chemical binding]; other site
205922017270	membrane-bound complex binding site; other site
205922017271	hinge residues; other site
205922017272	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922017273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017274	dimer interface [polypeptide binding]; other site
205922017275	conserved gate region; other site
205922017276	putative PBP binding loops; other site
205922017277	ABC-ATPase subunit interface; other site
205922017278	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
205922017279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017280	dimer interface [polypeptide binding]; other site
205922017281	conserved gate region; other site
205922017282	putative PBP binding loops; other site
205922017283	ABC-ATPase subunit interface; other site
205922017284	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
205922017285	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
205922017286	Walker A/P-loop; other site
205922017287	ATP binding site [chemical binding]; other site
205922017288	Q-loop/lid; other site
205922017289	ABC transporter signature motif; other site
205922017290	Walker B; other site
205922017291	D-loop; other site
205922017292	H-loop/switch region; other site
205922017293	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
205922017294	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
205922017295	polyphosphate kinase; Provisional; Region: PRK05443
205922017296	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
205922017297	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
205922017298	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
205922017299	putative active site [active]
205922017300	catalytic site [active]
205922017301	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
205922017302	putative domain interface [polypeptide binding]; other site
205922017303	putative active site [active]
205922017304	catalytic site [active]
205922017305	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
205922017306	dimer interface [polypeptide binding]; other site
205922017307	active site
205922017308	aspartate-rich active site metal binding site; other site
205922017309	allosteric magnesium binding site [ion binding]; other site
205922017310	Schiff base residues; other site
205922017311	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
205922017312	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
205922017313	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
205922017314	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
205922017315	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
205922017316	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
205922017317	conserved cys residue [active]
205922017318	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
205922017319	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
205922017320	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
205922017321	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
205922017322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
205922017323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
205922017324	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
205922017325	putative dimer interface [polypeptide binding]; other site
205922017326	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
205922017327	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
205922017328	LysE type translocator; Region: LysE; cl00565
205922017329	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
205922017330	Mechanosensitive ion channel; Region: MS_channel; pfam00924
205922017331	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
205922017332	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922017333	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922017334	ABC transporter; Region: ABC_tran_2; pfam12848
205922017335	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
205922017336	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
205922017337	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
205922017338	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
205922017339	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
205922017340	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
205922017341	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
205922017342	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
205922017343	HemY protein N-terminus; Region: HemY_N; pfam07219
205922017344	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
205922017345	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
205922017346	uroporphyrinogen-III synthase; Validated; Region: PRK05752
205922017347	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
205922017348	active site
205922017349	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
205922017350	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
205922017351	domain interfaces; other site
205922017352	active site
205922017353	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
205922017354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922017355	active site
205922017356	phosphorylation site [posttranslational modification]
205922017357	intermolecular recognition site; other site
205922017358	dimerization interface [polypeptide binding]; other site
205922017359	LytTr DNA-binding domain; Region: LytTR; pfam04397
205922017360	argininosuccinate lyase; Provisional; Region: PRK00855
205922017361	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
205922017362	active sites [active]
205922017363	tetramer interface [polypeptide binding]; other site
205922017364	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922017365	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
205922017366	C-terminal domain interface [polypeptide binding]; other site
205922017367	GSH binding site (G-site) [chemical binding]; other site
205922017368	dimer interface [polypeptide binding]; other site
205922017369	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
205922017370	putative N-terminal domain interface [polypeptide binding]; other site
205922017371	putative dimer interface [polypeptide binding]; other site
205922017372	putative substrate binding pocket (H-site) [chemical binding]; other site
205922017373	Phosphate-starvation-inducible E; Region: PsiE; cl01264
205922017374	adenylate cyclase; Provisional; Region: cyaA; PRK09450
205922017375	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
205922017376	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
205922017377	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
205922017378	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
205922017379	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
205922017380	frataxin-like protein; Provisional; Region: cyaY; PRK00446
205922017381	putative iron binding site [ion binding]; other site
205922017382	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
205922017383	diaminopimelate decarboxylase; Region: lysA; TIGR01048
205922017384	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
205922017385	active site
205922017386	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922017387	substrate binding site [chemical binding]; other site
205922017388	catalytic residues [active]
205922017389	dimer interface [polypeptide binding]; other site
205922017390	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
205922017391	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
205922017392	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
205922017393	Protein of unknown function, DUF484; Region: DUF484; cl17449
205922017394	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
205922017395	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
205922017396	active site
205922017397	DNA binding site [nucleotide binding]
205922017398	Int/Topo IB signature motif; other site
205922017399	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
205922017400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
205922017401	motif II; other site
205922017402	Uncharacterized conserved protein [Function unknown]; Region: COG0432
205922017403	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
205922017404	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
205922017405	Nitrogen regulatory protein P-II; Region: P-II; smart00938
205922017406	Membrane fusogenic activity; Region: BMFP; pfam04380
205922017407	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
205922017408	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
205922017409	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
205922017410	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
205922017411	adenylylsulfate kinase; Provisional; Region: PRK05541
205922017412	active site
205922017413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922017414	S-adenosylmethionine binding site [chemical binding]; other site
205922017415	hypothetical protein; Provisional; Region: PRK05849
205922017416	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
205922017417	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
205922017418	Peptidase C26; Region: Peptidase_C26; pfam07722
205922017419	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
205922017420	catalytic triad [active]
205922017421	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
205922017422	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
205922017423	active site
205922017424	metal-binding site
205922017425	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
205922017426	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
205922017427	dimerization interface [polypeptide binding]; other site
205922017428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
205922017429	dimer interface [polypeptide binding]; other site
205922017430	putative CheW interface [polypeptide binding]; other site
205922017431	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
205922017432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922017433	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
205922017434	dimerization interface [polypeptide binding]; other site
205922017435	substrate binding pocket [chemical binding]; other site
205922017436	multidrug efflux protein NorA; Provisional; Region: PRK00187
205922017437	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
205922017438	cation binding site [ion binding]; other site
205922017439	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922017440	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922017441	metal binding site [ion binding]; metal-binding site
205922017442	active site
205922017443	I-site; other site
205922017444	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922017445	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
205922017446	Part of AAA domain; Region: AAA_19; pfam13245
205922017447	Family description; Region: UvrD_C_2; pfam13538
205922017448	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922017449	active site
205922017450	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
205922017451	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
205922017452	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
205922017453	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
205922017454	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
205922017455	non-specific DNA binding site [nucleotide binding]; other site
205922017456	salt bridge; other site
205922017457	sequence-specific DNA binding site [nucleotide binding]; other site
205922017458	Cupin domain; Region: Cupin_2; pfam07883
205922017459	alanine racemase; Reviewed; Region: dadX; PRK03646
205922017460	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
205922017461	active site
205922017462	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
205922017463	substrate binding site [chemical binding]; other site
205922017464	catalytic residues [active]
205922017465	dimer interface [polypeptide binding]; other site
205922017466	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
205922017467	homotrimer interaction site [polypeptide binding]; other site
205922017468	putative active site [active]
205922017469	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
205922017470	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
205922017471	hydroxyglutarate oxidase; Provisional; Region: PRK11728
205922017472	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
205922017473	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922017474	putative DNA binding site [nucleotide binding]; other site
205922017475	putative Zn2+ binding site [ion binding]; other site
205922017476	AsnC family; Region: AsnC_trans_reg; pfam01037
205922017477	Flagellin N-methylase; Region: FliB; pfam03692
205922017478	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
205922017479	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
205922017480	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
205922017481	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922017482	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922017483	DNA-binding site [nucleotide binding]; DNA binding site
205922017484	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922017485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922017486	homodimer interface [polypeptide binding]; other site
205922017487	catalytic residue [active]
205922017488	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
205922017489	PLD-like domain; Region: PLDc_2; pfam13091
205922017490	putative active site [active]
205922017491	catalytic site [active]
205922017492	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
205922017493	PLD-like domain; Region: PLDc_2; pfam13091
205922017494	putative active site [active]
205922017495	catalytic site [active]
205922017496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922017497	putative substrate translocation pore; other site
205922017498	Major Facilitator Superfamily; Region: MFS_1; pfam07690
205922017499	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
205922017500	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
205922017501	NAD(P) binding site [chemical binding]; other site
205922017502	catalytic residues [active]
205922017503	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
205922017504	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
205922017505	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
205922017506	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
205922017507	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
205922017508	peptide binding site [polypeptide binding]; other site
205922017509	hypothetical protein; Reviewed; Region: PRK00024
205922017510	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
205922017511	MPN+ (JAMM) motif; other site
205922017512	Zinc-binding site [ion binding]; other site
205922017513	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
205922017514	Flavoprotein; Region: Flavoprotein; pfam02441
205922017515	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
205922017516	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
205922017517	trimer interface [polypeptide binding]; other site
205922017518	active site
205922017519	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
205922017520	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
205922017521	active site
205922017522	substrate binding site [chemical binding]; other site
205922017523	metal binding site [ion binding]; metal-binding site
205922017524	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
205922017525	feedback inhibition sensing region; other site
205922017526	homohexameric interface [polypeptide binding]; other site
205922017527	nucleotide binding site [chemical binding]; other site
205922017528	N-acetyl-L-glutamate binding site [chemical binding]; other site
205922017529	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
205922017530	active site
205922017531	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
205922017532	putative active site [active]
205922017533	putative catalytic site [active]
205922017534	putative DNA binding site [nucleotide binding]; other site
205922017535	putative phosphate binding site [ion binding]; other site
205922017536	metal binding site A [ion binding]; metal-binding site
205922017537	putative AP binding site [nucleotide binding]; other site
205922017538	putative metal binding site B [ion binding]; other site
205922017539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
205922017540	ribonuclease PH; Reviewed; Region: rph; PRK00173
205922017541	Ribonuclease PH; Region: RNase_PH_bact; cd11362
205922017542	hexamer interface [polypeptide binding]; other site
205922017543	active site
205922017544	hypothetical protein; Provisional; Region: PRK11820
205922017545	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
205922017546	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
205922017547	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
205922017548	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
205922017549	catalytic site [active]
205922017550	G-X2-G-X-G-K; other site
205922017551	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
205922017552	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
205922017553	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
205922017554	Zn2+ binding site [ion binding]; other site
205922017555	Mg2+ binding site [ion binding]; other site
205922017556	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
205922017557	synthetase active site [active]
205922017558	NTP binding site [chemical binding]; other site
205922017559	metal binding site [ion binding]; metal-binding site
205922017560	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
205922017561	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
205922017562	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
205922017563	homotrimer interaction site [polypeptide binding]; other site
205922017564	putative active site [active]
205922017565	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
205922017566	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922017567	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
205922017568	putative NAD(P) binding site [chemical binding]; other site
205922017569	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
205922017570	biopolymer transport protein ExbD; Provisional; Region: PRK11267
205922017571	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
205922017572	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
205922017573	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
205922017574	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
205922017575	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922017576	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
205922017577	dimerization interface [polypeptide binding]; other site
205922017578	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
205922017579	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
205922017580	generic binding surface II; other site
205922017581	ssDNA binding site; other site
205922017582	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
205922017583	ATP binding site [chemical binding]; other site
205922017584	putative Mg++ binding site [ion binding]; other site
205922017585	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
205922017586	nucleotide binding region [chemical binding]; other site
205922017587	ATP-binding site [chemical binding]; other site
205922017588	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
205922017589	putative deacylase active site [active]
205922017590	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
205922017591	SCP-2 sterol transfer family; Region: SCP2; pfam02036
205922017592	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
205922017593	TPR repeat; Region: TPR_11; pfam13414
205922017594	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
205922017595	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
205922017596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922017597	TIGR01777 family protein; Region: yfcH
205922017598	NAD(P) binding site [chemical binding]; other site
205922017599	active site
205922017600	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922017601	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922017602	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922017603	Protein kinase domain; Region: Pkinase; pfam00069
205922017604	Catalytic domain of Protein Kinases; Region: PKc; cd00180
205922017605	active site
205922017606	ATP binding site [chemical binding]; other site
205922017607	substrate binding site [chemical binding]; other site
205922017608	activation loop (A-loop); other site
205922017609	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
205922017610	Protein phosphatase 2C; Region: PP2C; pfam00481
205922017611	active site
205922017612	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
205922017613	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
205922017614	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
205922017615	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
205922017616	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
205922017617	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
205922017618	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
205922017619	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
205922017620	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
205922017621	phosphopeptide binding site; other site
205922017622	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
205922017623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922017624	Walker A motif; other site
205922017625	ATP binding site [chemical binding]; other site
205922017626	Walker B motif; other site
205922017627	arginine finger; other site
205922017628	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
205922017629	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
205922017630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922017631	Walker A motif; other site
205922017632	ATP binding site [chemical binding]; other site
205922017633	Walker B motif; other site
205922017634	arginine finger; other site
205922017635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922017636	Walker A motif; other site
205922017637	ATP binding site [chemical binding]; other site
205922017638	Walker B motif; other site
205922017639	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
205922017640	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
205922017641	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
205922017642	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
205922017643	Uncharacterized conserved protein [Function unknown]; Region: COG4104
205922017644	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
205922017645	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
205922017646	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
205922017647	Protein of unknown function (DUF877); Region: DUF877; pfam05943
205922017648	Protein of unknown function (DUF770); Region: DUF770; pfam05591
205922017649	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
205922017650	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
205922017651	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
205922017652	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
205922017653	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
205922017654	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
205922017655	Protein of unknown function (DUF2931); Region: DUF2931; pfam11153
205922017656	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
205922017657	IHF dimer interface [polypeptide binding]; other site
205922017658	IHF - DNA interface [nucleotide binding]; other site
205922017659	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
205922017660	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922017661	Rubredoxin [Energy production and conversion]; Region: COG1773
205922017662	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
205922017663	iron binding site [ion binding]; other site
205922017664	Chorismate lyase; Region: Chor_lyase; cl01230
205922017665	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
205922017666	UbiA prenyltransferase family; Region: UbiA; pfam01040
205922017667	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
205922017668	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
205922017669	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
205922017670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922017671	active site
205922017672	phosphorylation site [posttranslational modification]
205922017673	intermolecular recognition site; other site
205922017674	dimerization interface [polypeptide binding]; other site
205922017675	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922017676	DNA binding site [nucleotide binding]
205922017677	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
205922017678	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
205922017679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922017680	putative active site [active]
205922017681	heme pocket [chemical binding]; other site
205922017682	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922017683	dimer interface [polypeptide binding]; other site
205922017684	phosphorylation site [posttranslational modification]
205922017685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922017686	ATP binding site [chemical binding]; other site
205922017687	Mg2+ binding site [ion binding]; other site
205922017688	G-X-G motif; other site
205922017689	Domain of unknown function DUF21; Region: DUF21; pfam01595
205922017690	gliding motility-associated protein GldE; Region: GldE; TIGR03520
205922017691	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
205922017692	Transporter associated domain; Region: CorC_HlyC; pfam03471
205922017693	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
205922017694	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
205922017695	Peptidase family M23; Region: Peptidase_M23; pfam01551
205922017696	Response regulator receiver domain; Region: Response_reg; pfam00072
205922017697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922017698	active site
205922017699	phosphorylation site [posttranslational modification]
205922017700	intermolecular recognition site; other site
205922017701	dimerization interface [polypeptide binding]; other site
205922017702	transcriptional regulator PhoU; Provisional; Region: PRK11115
205922017703	PhoU domain; Region: PhoU; pfam01895
205922017704	PhoU domain; Region: PhoU; pfam01895
205922017705	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
205922017706	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
205922017707	Walker A/P-loop; other site
205922017708	ATP binding site [chemical binding]; other site
205922017709	Q-loop/lid; other site
205922017710	ABC transporter signature motif; other site
205922017711	Walker B; other site
205922017712	D-loop; other site
205922017713	H-loop/switch region; other site
205922017714	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
205922017715	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
205922017716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017717	dimer interface [polypeptide binding]; other site
205922017718	conserved gate region; other site
205922017719	putative PBP binding loops; other site
205922017720	ABC-ATPase subunit interface; other site
205922017721	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
205922017722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
205922017723	dimer interface [polypeptide binding]; other site
205922017724	conserved gate region; other site
205922017725	putative PBP binding loops; other site
205922017726	ABC-ATPase subunit interface; other site
205922017727	PBP superfamily domain; Region: PBP_like_2; cl17296
205922017728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922017729	metabolite-proton symporter; Region: 2A0106; TIGR00883
205922017730	putative substrate translocation pore; other site
205922017731	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
205922017732	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
205922017733	active site
205922017734	phosphate binding residues; other site
205922017735	catalytic residues [active]
205922017736	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
205922017737	Predicted membrane protein [Function unknown]; Region: COG2261
205922017738	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
205922017739	ATP-grasp domain; Region: ATP-grasp; pfam02222
205922017740	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
205922017741	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
205922017742	active site
205922017743	cell density-dependent motility repressor; Provisional; Region: PRK10082
205922017744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922017745	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
205922017746	dimerization interface [polypeptide binding]; other site
205922017747	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
205922017748	Aspartase; Region: Aspartase; cd01357
205922017749	active sites [active]
205922017750	tetramer interface [polypeptide binding]; other site
205922017751	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
205922017752	amino acid carrier protein; Region: agcS; TIGR00835
205922017753	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
205922017754	active site
205922017755	homodimer interface [polypeptide binding]; other site
205922017756	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
205922017757	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
205922017758	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
205922017759	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
205922017760	active site
205922017761	Zn binding site [ion binding]; other site
205922017762	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
205922017763	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
205922017764	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
205922017765	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
205922017766	DNA-binding site [nucleotide binding]; DNA binding site
205922017767	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
205922017768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
205922017769	homodimer interface [polypeptide binding]; other site
205922017770	catalytic residue [active]
205922017771	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
205922017772	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
205922017773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
205922017774	Coenzyme A binding pocket [chemical binding]; other site
205922017775	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
205922017776	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
205922017777	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
205922017778	Autotransporter beta-domain; Region: Autotransporter; smart00869
205922017779	Autotransporter beta-domain; Region: Autotransporter; smart00869
205922017780	pyruvate carboxylase subunit B; Validated; Region: PRK09282
205922017781	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
205922017782	active site
205922017783	catalytic residues [active]
205922017784	metal binding site [ion binding]; metal-binding site
205922017785	homodimer binding site [polypeptide binding]; other site
205922017786	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
205922017787	carboxyltransferase (CT) interaction site; other site
205922017788	biotinylation site [posttranslational modification]; other site
205922017789	pyruvate carboxylase subunit A; Validated; Region: PRK07178
205922017790	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
205922017791	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
205922017792	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
205922017793	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922017794	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922017795	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
205922017796	putative dimerization interface [polypeptide binding]; other site
205922017797	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
205922017798	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
205922017799	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
205922017800	putative active site [active]
205922017801	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922017802	PAS fold; Region: PAS_3; pfam08447
205922017803	putative active site [active]
205922017804	heme pocket [chemical binding]; other site
205922017805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922017806	PAS domain; Region: PAS_9; pfam13426
205922017807	putative active site [active]
205922017808	heme pocket [chemical binding]; other site
205922017809	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
205922017810	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
205922017811	metal binding site [ion binding]; metal-binding site
205922017812	active site
205922017813	I-site; other site
205922017814	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
205922017815	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
205922017816	Part of AAA domain; Region: AAA_19; pfam13245
205922017817	Family description; Region: UvrD_C_2; pfam13538
205922017818	Predicted membrane protein [Function unknown]; Region: COG2510
205922017819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
205922017820	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
205922017821	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
205922017822	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
205922017823	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
205922017824	pyridoxamine kinase; Validated; Region: PRK05756
205922017825	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
205922017826	pyridoxal binding site [chemical binding]; other site
205922017827	dimer interface [polypeptide binding]; other site
205922017828	ATP binding site [chemical binding]; other site
205922017829	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
205922017830	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
205922017831	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
205922017832	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
205922017833	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
205922017834	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
205922017835	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
205922017836	AMIN domain; Region: AMIN; pfam11741
205922017837	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
205922017838	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
205922017839	active site
205922017840	metal binding site [ion binding]; metal-binding site
205922017841	putative GTP cyclohydrolase; Provisional; Region: PRK13674
205922017842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
205922017843	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
205922017844	Walker A/P-loop; other site
205922017845	ATP binding site [chemical binding]; other site
205922017846	Q-loop/lid; other site
205922017847	ABC transporter signature motif; other site
205922017848	Walker B; other site
205922017849	D-loop; other site
205922017850	H-loop/switch region; other site
205922017851	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
205922017852	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
205922017853	ABC-ATPase subunit  interface; other site
205922017854	dimer interface [polypeptide binding]; other site
205922017855	putative PBP binding regions; other site
205922017856	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
205922017857	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
205922017858	metal binding site [ion binding]; metal-binding site
205922017859	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
205922017860	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
205922017861	trimer interface [polypeptide binding]; other site
205922017862	active site
205922017863	dihydroorotase; Reviewed; Region: PRK09236
205922017864	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
205922017865	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
205922017866	active site
205922017867	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
205922017868	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
205922017869	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
205922017870	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
205922017871	putative active site [active]
205922017872	catalytic site [active]
205922017873	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
205922017874	putative active site [active]
205922017875	catalytic site [active]
205922017876	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
205922017877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922017878	S-adenosylmethionine binding site [chemical binding]; other site
205922017879	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
205922017880	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
205922017881	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
205922017882	HflK protein; Region: hflK; TIGR01933
205922017883	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
205922017884	HflC protein; Region: hflC; TIGR01932
205922017885	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
205922017886	HflK protein; Region: hflK; TIGR01933
205922017887	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
205922017888	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
205922017889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
205922017890	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
205922017891	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
205922017892	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922017893	putative DNA binding site [nucleotide binding]; other site
205922017894	putative Zn2+ binding site [ion binding]; other site
205922017895	AsnC family; Region: AsnC_trans_reg; pfam01037
205922017896	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
205922017897	TPR repeat; Region: TPR_11; pfam13414
205922017898	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
205922017899	Methyltransferase domain; Region: Methyltransf_11; pfam08241
205922017900	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
205922017901	Methyltransferase domain; Region: Methyltransf_31; pfam13847
205922017902	Methyltransferase domain; Region: Methyltransf_11; pfam08241
205922017903	hydrogenase 2 large subunit; Provisional; Region: PRK10467
205922017904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922017905	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
205922017906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922017907	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
205922017908	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
205922017909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
205922017910	NAD(P) binding site [chemical binding]; other site
205922017911	active site
205922017912	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
205922017913	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
205922017914	NADP-binding site; other site
205922017915	homotetramer interface [polypeptide binding]; other site
205922017916	substrate binding site [chemical binding]; other site
205922017917	homodimer interface [polypeptide binding]; other site
205922017918	active site
205922017919	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
205922017920	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
205922017921	Substrate binding site; other site
205922017922	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
205922017923	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
205922017924	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
205922017925	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
205922017926	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
205922017927	Walker A/P-loop; other site
205922017928	ATP binding site [chemical binding]; other site
205922017929	Q-loop/lid; other site
205922017930	ABC transporter signature motif; other site
205922017931	Walker B; other site
205922017932	D-loop; other site
205922017933	H-loop/switch region; other site
205922017934	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
205922017935	putative carbohydrate binding site [chemical binding]; other site
205922017936	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
205922017937	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922017938	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922017939	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
205922017940	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
205922017941	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
205922017942	putative ADP-binding pocket [chemical binding]; other site
205922017943	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
205922017944	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
205922017945	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
205922017946	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
205922017947	FAD binding pocket [chemical binding]; other site
205922017948	FAD binding motif [chemical binding]; other site
205922017949	phosphate binding motif [ion binding]; other site
205922017950	beta-alpha-beta structure motif; other site
205922017951	NAD binding pocket [chemical binding]; other site
205922017952	Heme binding  pocket [chemical binding]; other site
205922017953	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
205922017954	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
205922017955	catalytic loop [active]
205922017956	iron binding site [ion binding]; other site
205922017957	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
205922017958	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
205922017959	putative C-terminal domain interface [polypeptide binding]; other site
205922017960	putative GSH binding site (G-site) [chemical binding]; other site
205922017961	putative dimer interface [polypeptide binding]; other site
205922017962	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
205922017963	putative N-terminal domain interface [polypeptide binding]; other site
205922017964	putative dimer interface [polypeptide binding]; other site
205922017965	putative substrate binding pocket (H-site) [chemical binding]; other site
205922017966	Transcriptional regulator [Transcription]; Region: LysR; COG0583
205922017967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
205922017968	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
205922017969	putative effector binding pocket; other site
205922017970	putative dimerization interface [polypeptide binding]; other site
205922017971	cyclase homology domain; Region: CHD; cd07302
205922017972	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
205922017973	nucleotidyl binding site; other site
205922017974	metal binding site [ion binding]; metal-binding site
205922017975	dimer interface [polypeptide binding]; other site
205922017976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
205922017977	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205922017978	Walker A motif; other site
205922017979	ATP binding site [chemical binding]; other site
205922017980	Walker B motif; other site
205922017981	arginine finger; other site
205922017982	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
205922017983	active site
205922017984	catalytic triad [active]
205922017985	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
205922017986	Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
205922017987	active site
205922017988	catalytic triad [active]
205922017989	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
205922017990	Epoxide hydrolase N terminus; Region: EHN; pfam06441
205922017991	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
205922017992	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
205922017993	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
205922017994	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
205922017995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
205922017996	dimer interface [polypeptide binding]; other site
205922017997	phosphorylation site [posttranslational modification]
205922017998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922017999	Mg2+ binding site [ion binding]; other site
205922018000	G-X-G motif; other site
205922018001	osmolarity response regulator; Provisional; Region: ompR; PRK09468
205922018002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922018003	active site
205922018004	phosphorylation site [posttranslational modification]
205922018005	intermolecular recognition site; other site
205922018006	dimerization interface [polypeptide binding]; other site
205922018007	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922018008	DNA binding site [nucleotide binding]
205922018009	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
205922018010	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
205922018011	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
205922018012	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
205922018013	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
205922018014	catalytic residues [active]
205922018015	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
205922018016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
205922018017	active site
205922018018	phosphorylation site [posttranslational modification]
205922018019	intermolecular recognition site; other site
205922018020	dimerization interface [polypeptide binding]; other site
205922018021	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
205922018022	DNA binding residues [nucleotide binding]
205922018023	dimerization interface [polypeptide binding]; other site
205922018024	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
205922018025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922018026	putative active site [active]
205922018027	heme pocket [chemical binding]; other site
205922018028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
205922018029	putative active site [active]
205922018030	heme pocket [chemical binding]; other site
205922018031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
205922018032	dimer interface [polypeptide binding]; other site
205922018033	phosphorylation site [posttranslational modification]
205922018034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
205922018035	ATP binding site [chemical binding]; other site
205922018036	Mg2+ binding site [ion binding]; other site
205922018037	G-X-G motif; other site
205922018038	benzoate transport; Region: 2A0115; TIGR00895
205922018039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
205922018040	putative substrate translocation pore; other site
205922018041	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
205922018042	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
205922018043	DNA binding site [nucleotide binding]
205922018044	Predicted ATPase [General function prediction only]; Region: COG3903
205922018045	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
205922018046	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
205922018047	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
205922018048	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
205922018049	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
205922018050	TniQ; Region: TniQ; pfam06527
205922018051	TniQ; Region: TniQ; pfam06527
205922018052	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
205922018053	Integrase core domain; Region: rve; pfam00665
205922018054	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
205922018055	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
205922018056	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
205922018057	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
205922018058	glutaminase active site [active]
205922018059	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
205922018060	dimer interface [polypeptide binding]; other site
205922018061	active site
205922018062	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
205922018063	dimer interface [polypeptide binding]; other site
205922018064	active site
205922018065	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
205922018066	putative DNA binding site [nucleotide binding]; other site
205922018067	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
205922018068	putative Zn2+ binding site [ion binding]; other site
205922018069	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
205922018070	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
205922018071	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
205922018072	Substrate binding site; other site
205922018073	Mg++ binding site; other site
205922018074	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
205922018075	active site
205922018076	substrate binding site [chemical binding]; other site
205922018077	CoA binding site [chemical binding]; other site
205922018078	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
205922018079	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
205922018080	gamma subunit interface [polypeptide binding]; other site
205922018081	epsilon subunit interface [polypeptide binding]; other site
205922018082	LBP interface [polypeptide binding]; other site
205922018083	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
205922018084	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
205922018085	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
205922018086	alpha subunit interaction interface [polypeptide binding]; other site
205922018087	Walker A motif; other site
205922018088	ATP binding site [chemical binding]; other site
205922018089	Walker B motif; other site
205922018090	inhibitor binding site; inhibition site
205922018091	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
205922018092	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
205922018093	core domain interface [polypeptide binding]; other site
205922018094	delta subunit interface [polypeptide binding]; other site
205922018095	epsilon subunit interface [polypeptide binding]; other site
205922018096	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
205922018097	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
205922018098	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
205922018099	beta subunit interaction interface [polypeptide binding]; other site
205922018100	Walker A motif; other site
205922018101	ATP binding site [chemical binding]; other site
205922018102	Walker B motif; other site
205922018103	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
205922018104	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
205922018105	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
205922018106	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
205922018107	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
205922018108	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
205922018109	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
205922018110	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
205922018111	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
205922018112	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
205922018113	ParB-like nuclease domain; Region: ParBc; pfam02195
205922018114	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
205922018115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922018116	P-loop; other site
205922018117	Magnesium ion binding site [ion binding]; other site
205922018118	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
205922018119	Magnesium ion binding site [ion binding]; other site
205922018120	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
205922018121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
205922018122	S-adenosylmethionine binding site [chemical binding]; other site
205922018123	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
205922018124	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
205922018125	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
205922018126	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
205922018127	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
205922018128	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
205922018129	trmE is a tRNA modification GTPase; Region: trmE; cd04164
205922018130	G1 box; other site
205922018131	GTP/Mg2+ binding site [chemical binding]; other site
205922018132	Switch I region; other site
205922018133	G2 box; other site
205922018134	Switch II region; other site
205922018135	G3 box; other site
205922018136	G4 box; other site
205922018137	G5 box; other site
205922018138	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
205922018139	membrane protein insertase; Provisional; Region: PRK01318
205922018140	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
205922018141	hypothetical protein; Provisional; Region: PRK14371
205922018142	ribonuclease P; Reviewed; Region: rnpA; PRK00396