-- dump date 20140620_001210 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_003686962.1 297625199 9282011 241..1707 1 NC_014215.1 DnaA, ATPase involved in DNA replication initiation; chromosomal replication initiator protein 1707 dnaA 9282011 dnaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chromosomal replication initiator protein YP_003686962.1 241 D 754252 CDS YP_003686963.1 297625200 9283507 complement(1682..3151) 1 NC_014215.1 Multidrug resistance transporter, MFS superfamily protein 3151 9283507 PFREUD_00020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Multidrug resistance transporter, MFS superfamily protein YP_003686963.1 1682 R 754252 CDS YP_003686964.1 297625201 9282012 3393..4010 1 NC_014215.1 transcriptional regulator 4010 9282012 PFREUD_00030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003686964.1 3393 D 754252 CDS YP_003686965.1 297625202 9282013 complement(4007..5188) 1 NC_014215.1 1,4-alpha-D-glucan <=> 1,4-alpha-D-glucan; glycosyltransferase family protein 5188 SqdX 9282013 SqdX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyltransferase family protein YP_003686965.1 4007 R 754252 CDS YP_003686966.1 297625203 9284297 complement(5202..6449) 1 NC_014215.1 UDP-glucose + HSO3- <=> UDP-6-sulfoquinovose + H2O; UDP-sulfoquinovose synthase 6449 sqdB 9284297 sqdB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-sulfoquinovose synthase YP_003686966.1 5202 R 754252 CDS YP_003686967.1 297625204 9284296 6930..7865 1 NC_014215.1 ABC transporter ATP-binding protein 7865 9284296 PFREUD_00060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003686967.1 6930 D 754252 CDS YP_003686968.1 297625205 9282014 7804..10425 1 NC_014215.1 ABC transporter 10425 9282014 PFREUD_00070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003686968.1 7804 D 754252 CDS YP_003686969.1 297625206 9282015 12301..13461 1 NC_014215.1 DNA polymerase III subunit beta 13461 dnaN 9282015 dnaN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase III subunit beta YP_003686969.1 12301 D 754252 CDS YP_003686970.1 297625207 9283518 13535..14836 1 NC_014215.1 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage; DNA replication and repair protein RecF 14836 recF 9283518 recF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA replication and repair protein RecF YP_003686970.1 13535 D 754252 CDS YP_003686971.1 297625208 9284165 14748..15611 1 NC_014215.1 hypothetical protein 15611 9284165 PFREUD_00100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686971.1 14748 D 754252 CDS YP_003686972.1 297625209 9282016 15864..17531 1 NC_014215.1 hypothetical protein 17531 9282016 PFREUD_00110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686972.1 15864 D 754252 CDS YP_003686973.1 297625210 9282017 17774..18334 1 NC_014215.1 hypothetical protein 18334 9282017 PFREUD_00120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686973.1 17774 D 754252 CDS YP_003686974.1 297625211 9282018 18375..18449 1 NC_014215.1 hypothetical protein 18449 9282018 PFREUD_00130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686974.1 18375 D 754252 CDS YP_003686975.1 297625212 9282019 18416..19723 1 NC_014215.1 transposase 19723 tnpA 9282019 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003686975.1 18416 D 754252 CDS YP_003686976.1 297625213 9284350 19746..20222 1 NC_014215.1 hypothetical protein 20222 9284350 PFREUD_00140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686976.1 19746 D 754252 CDS YP_003686977.1 297625214 9282020 20643..22685 1 NC_014215.1 DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. ATP-dependent breakage, passage and rejoining of double-stranded DNA. Belongs to the type II topoisomerase family; DNA gyrase subunit B 22685 gyrB2 9282020 gyrB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA gyrase subunit B YP_003686977.1 20643 D 754252 CDS YP_003686978.1 297625215 9283683 22732..25467 1 NC_014215.1 DNA gyrase subunit A 25467 gyrA 9283683 gyrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA gyrase subunit A YP_003686978.1 22732 D 754252 CDS YP_003686979.1 297625216 9283680 25689..26573 1 NC_014215.1 hypothetical protein 26573 9283680 PFREUD_00170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686979.1 25689 D 754252 CDS YP_003686980.1 297625217 9282021 complement(26704..26979) 1 NC_014215.1 hypothetical protein 26979 9282021 PFREUD_00180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686980.1 26704 R 754252 CDS YP_003686981.1 297625218 9282022 27220..28017 1 NC_014215.1 hypothetical protein 28017 9282022 PFREUD_00190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686981.1 27220 D 754252 CDS YP_003686982.1 297625219 9282023 28082..28654 1 NC_014215.1 hypothetical protein 28654 9282023 PFREUD_00200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686982.1 28082 D 754252 CDS YP_003686983.1 297625220 9282024 28651..29739 1 NC_014215.1 S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine <=> 5 prime-deoxyadenosine + L-methionine + Flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical; pyruvate-formate lyase-activating enzyme 29739 pflA 9282024 pflA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyruvate-formate lyase-activating enzyme YP_003686983.1 28651 D 754252 CDS YP_003686984.1 297625221 9284056 29896..30414 1 NC_014215.1 hypothetical protein 30414 9284056 PFREUD_00220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686984.1 29896 D 754252 CDS YP_003686985.1 297625222 9282026 30652..31098 1 NC_014215.1 hypothetical protein 31098 9282026 PFREUD_00240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686985.1 30652 D 754252 CDS YP_003686986.1 297625223 9282027 31113..31571 1 NC_014215.1 hypothetical protein 31571 9282027 PFREUD_00250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686986.1 31113 D 754252 CDS YP_003686987.1 297625224 9282028 complement(31608..32018) 1 NC_014215.1 hypothetical protein 32018 9282028 PFREUD_00260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686987.1 31608 R 754252 CDS YP_003686988.1 297625225 9283805 33208..33366 1 NC_014215.1 hypothetical protein 33366 9283805 PFREUD_00280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003686988.1 33208 D 754252 CDS YP_003686989.1 297625226 9282030 33744..34934 1 NC_014215.1 myo-inositol + NAD+ <=> 2,4,6/3,5-Pentahydroxycyclohexanone + NADH + H+; myo-inositol 2-dehydrogenase 34934 iol 9282030 iol Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol 2-dehydrogenase YP_003686989.1 33744 D 754252 CDS YP_003686990.1 297625227 9283782 34951..36603 1 NC_014215.1 myo-inositol transporter 36603 iolT2 9283782 iolT2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol transporter YP_003686990.1 34951 D 754252 CDS YP_003686991.1 297625228 9283791 complement(36839..37498) 1 NC_014215.1 two-component system response regulator 37498 9283791 PFREUD_00310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system response regulator YP_003686991.1 36839 R 754252 CDS YP_003686992.1 297625229 9282031 complement(37495..38997) 1 NC_014215.1 two-component system sensor kinase 38997 9282031 PFREUD_00320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system sensor kinase YP_003686992.1 37495 R 754252 CDS YP_003686993.1 297625230 9282032 complement(39199..40533) 1 NC_014215.1 transporter 40533 9282032 PFREUD_00330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transporter YP_003686993.1 39199 R 754252 CDS YP_003686994.1 297625231 9282033 complement(40552..41763) 1 NC_014215.1 carboxypeptidase activity; amidohydrolase 41763 9282033 PFREUD_00340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amidohydrolase YP_003686994.1 40552 R 754252 CDS YP_003686995.1 297625232 9282034 42453..44192 1 NC_014215.1 ABC transporter 44192 9282034 PFREUD_00350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003686995.1 42453 D 754252 CDS YP_003686996.1 297625233 9282035 44192..46159 1 NC_014215.1 ABC transporter 46159 9282035 PFREUD_00360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003686996.1 44192 D 754252 CDS YP_003686997.1 297625234 9282036 46374..47489 1 NC_014215.1 L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH; alanine dehydrogenase 47489 ald 9282036 ald Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alanine dehydrogenase YP_003686997.1 46374 D 754252 CDS YP_003686998.1 297625235 9283306 47857..49395 1 NC_014215.1 D-serine/D-alanine/glycine transporter 49395 cycA2 9283306 cycA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-serine/D-alanine/glycine transporter YP_003686998.1 47857 D 754252 CDS YP_003686999.1 297625236 9283452 complement(49612..50748) 1 NC_014215.1 Several members of this family contain peptidoglycan binding domains. So these proteins may use peptidoglycan or a precursor as a substrate.; ErfK/YbiS/YcfS/YnhG 50748 9283452 PFREUD_00390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ErfK/YbiS/YcfS/YnhG YP_003686999.1 49612 R 754252 CDS YP_003687000.1 297625237 9282037 51199..51486 1 NC_014215.1 acylphosphatase 51486 acyP 9282037 acyP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acylphosphatase YP_003687000.1 51199 D 754252 CDS YP_003687001.1 297625238 9283295 complement(51519..52202) 1 NC_014215.1 hypothetical protein 52202 9283295 PFREUD_00410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687001.1 51519 R 754252 CDS YP_003687002.1 297625239 9282038 52333..52842 1 NC_014215.1 A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor.; nitroreductase 52842 9282038 PFREUD_00420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nitroreductase YP_003687002.1 52333 D 754252 CDS YP_003687003.1 297625240 9282039 53037..54728 1 NC_014215.1 hypothetical protein 54728 9282039 PFREUD_00430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687003.1 53037 D 754252 CDS YP_003687004.1 297625241 9282040 complement(54766..55494) 1 NC_014215.1 hypothetical protein 55494 9282040 PFREUD_00440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687004.1 54766 R 754252 CDS YP_003687005.1 297625242 9282041 complement(55317..56333) 1 NC_014215.1 hypothetical protein 56333 9282041 PFREUD_00450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687005.1 55317 R 754252 CDS YP_003687006.1 297625243 9282042 complement(56330..58423) 1 NC_014215.1 hypothetical protein 58423 9282042 PFREUD_00460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687006.1 56330 R 754252 CDS YP_003687007.1 297625244 9282043 complement(58479..59348) 1 NC_014215.1 dTTP + D-glucose 1-phosphate <=> Pyrophosphate + dTDP-glucose; glucose-1-phosphate thymidylyltransferase 59348 rmlA 9282043 rmlA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glucose-1-phosphate thymidylyltransferase YP_003687007.1 58479 R 754252 CDS YP_003687008.1 297625245 9284185 59488..60258 1 NC_014215.1 transferase activity, transferring glycosyl groups; family 2 glycosyl transferase 60258 9284185 PFREUD_00480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 family 2 glycosyl transferase YP_003687008.1 59488 D 754252 CDS YP_003687009.1 297625246 9282044 60255..60680 1 NC_014215.1 hypothetical protein 60680 9282044 PFREUD_00490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687009.1 60255 D 754252 CDS YP_003687010.1 297625247 9282045 60819..61700 1 NC_014215.1 transferase activity, transferring glycosyl groups; family 2 glycosyl transferase 61700 9282045 PFREUD_00500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 family 2 glycosyl transferase YP_003687010.1 60819 D 754252 CDS YP_003687011.1 297625248 9282046 complement(61769..63013) 1 NC_014215.1 polysaccharide biosynthesis protein 63013 9282046 PFREUD_00510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polysaccharide biosynthesis protein YP_003687011.1 61769 R 754252 CDS YP_003687012.1 297625249 9282047 63182..64915 1 NC_014215.1 transferring glycosyl groups; family 2 glycosyl transferase 64915 9282047 PFREUD_00520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 family 2 glycosyl transferase YP_003687012.1 63182 D 754252 CDS YP_003687013.1 297625250 9282048 complement(64998..66530) 1 NC_014215.1 possible EPS polymerase; hypothetical protein 66530 9282048 PFREUD_00530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687013.1 64998 R 754252 CDS YP_003687014.1 297625251 9282049 complement(66685..68169) 1 NC_014215.1 dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-L-mannose / The enzyme occurs in a complex with EC 1.1.1.133 dTDP-4-dehydrorhamnose reductase/ dTDP-6-deoxy-L-mannose + NADP+ <=> dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+; dTDP-4-dehydrorhamnose reductase / dTDP-4-dehydrorhamnose 3,5-epimerase 68169 rmlC 9282049 rmlC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dTDP-4-dehydrorhamnose reductase / dTDP-4-dehydrorhamnose 3,5-epimerase YP_003687014.1 66685 R 754252 CDS YP_003687015.1 297625252 9284187 complement(68150..69148) 1 NC_014215.1 dTDP-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O / dTDP-glucose <=> 4,6-Dideoxy-4-oxo-dTDP-D-glucose + H2O; DTDP-glucose 4,6-dehydratase 69148 rmlB 9284187 rmlB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DTDP-glucose 4,6-dehydratase YP_003687015.1 68150 R 754252 CDS YP_003687016.1 297625253 9284186 complement(69279..73313) 1 NC_014215.1 extracted as s-layer proteins; large surface protein A 73313 lspA 9284186 lspA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 large surface protein A YP_003687016.1 69279 R 754252 CDS YP_003687017.1 297625254 9283836 73606..74793 1 NC_014215.1 Molecular function: UDP-galactopyranose mutase activity, Biological process: lipopolysaccharide biosynthetic process. UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.; UDP-galactopyranose mutase 74793 glf 9283836 glf Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-galactopyranose mutase YP_003687017.1 73606 D 754252 CDS YP_003687018.1 297625255 9283611 74790..76802 1 NC_014215.1 transfer of sugar; family 2 glycosyltransferase 76802 gtfA 9283611 gtfA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 family 2 glycosyltransferase YP_003687018.1 74790 D 754252 CDS YP_003687019.1 297625256 9283667 76771..77691 1 NC_014215.1 sugar ABC transporter permease 77691 tagG1 9283667 tagG1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar ABC transporter permease YP_003687019.1 76771 D 754252 CDS YP_003687020.1 297625257 9284310 77691..78461 1 NC_014215.1 sugar ABC transporter 78461 tagG2 9284310 tagG2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar ABC transporter YP_003687020.1 77691 D 754252 CDS YP_003687021.1 297625258 9284311 complement(78574..80982) 1 NC_014215.1 glycosyltransferase 80982 gtfB 9284311 gtfB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyltransferase YP_003687021.1 78574 R 754252 CDS YP_003687022.1 297625259 9283668 complement(81158..82015) 1 NC_014215.1 transferase activity transferring glycosyl groups; family 2 glycosyltransferase 82015 gtfC 9283668 gtfC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 family 2 glycosyltransferase YP_003687022.1 81158 R 754252 CDS YP_003687023.1 297625260 9283669 complement(82012..82974) 1 NC_014215.1 transferase activity transferring glycosyl groups; family 2 glycosyl transferase 82974 gtfD 9283669 gtfD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 family 2 glycosyl transferase YP_003687023.1 82012 R 754252 CDS YP_003687024.1 297625261 9283670 complement(83198..83584) 1 NC_014215.1 thioredoxin 83584 trxA2 9283670 trxA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin YP_003687024.1 83198 R 754252 CDS YP_003687025.1 297625262 9284436 complement(83619..84062) 1 NC_014215.1 signal peptid detected according to SignalP. 3 TM domains according to TMHMM; hypothetical protein 84062 9284436 PFREUD_00650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687025.1 83619 R 754252 CDS YP_003687026.1 297625263 9282050 84556..84666 1 NC_014215.1 hypothetical protein 84666 9282050 PFREUD_00660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687026.1 84556 D 754252 CDS YP_003687027.1 297625264 9282051 complement(85247..86044) 1 NC_014215.1 1-acyl-sn-glycerol-3-phosphate acyltransferase 86044 9282051 PFREUD_00670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_003687027.1 85247 R 754252 CDS YP_003687028.1 297625265 9282052 complement(86044..86850) 1 NC_014215.1 dehydrogenase 86850 9282052 PFREUD_00680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dehydrogenase YP_003687028.1 86044 R 754252 CDS YP_003687029.1 297625266 9282053 complement(86953..88143) 1 NC_014215.1 ATP + Propanoate <=> ADP + Propanoyl phosphate / ATP + acetate <=> ADP + acetyl phosphate; acetate kinase 88143 ackA 9282053 ackA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetate kinase YP_003687029.1 86953 R 754252 CDS YP_003687030.1 297625267 9283290 complement(88304..89836) 1 NC_014215.1 acetyl-CoA + Orthophosphate <=> CoA + acetyl phosphate / Propanoyl-CoA + Orthophosphate <=> Propanoyl phosphate + CoA; phosphate acetyltransferase 89836 pta 9283290 pta Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphate acetyltransferase YP_003687030.1 88304 R 754252 CDS YP_003687031.1 297625268 9284134 complement(90014..93412) 1 NC_014215.1 helicase 93412 hepA 9284134 hepA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 helicase YP_003687031.1 90014 R 754252 CDS YP_003687032.1 297625269 9283697 94210..94494 1 NC_014215.1 transposase IS3/IS911 94494 tnpA 9283697 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687032.1 94210 D 754252 CDS YP_003687033.1 297625270 9284351 94557..95360 1 NC_014215.1 integrase 95360 int 9284351 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687033.1 94557 D 754252 CDS YP_003687034.1 297625271 9283761 95357..96445 1 NC_014215.1 hypothetical protein 96445 9283761 PFREUD_00720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687034.1 95357 D 754252 CDS YP_003687035.1 297625272 9282054 complement(96463..97488) 1 NC_014215.1 hypothetical protein 97488 9282054 PFREUD_00730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687035.1 96463 R 754252 CDS YP_003687036.1 297625273 9282055 97697..97771 1 NC_014215.1 hypothetical protein 97771 9282055 PFREUD_00740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687036.1 97697 D 754252 CDS YP_003687037.1 297625274 9282056 97738..99045 1 NC_014215.1 transposase 99045 tnpA 9282056 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687037.1 97738 D 754252 CDS YP_003687038.1 297625275 9284352 99104..100267 1 NC_014215.1 phenol sulfate + H(2)O = a phenol + sulfate; arylsulfatase 100267 aslB 9284352 aslB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arylsulfatase YP_003687038.1 99104 D 754252 CDS YP_003687039.1 297625276 9283358 100696..102252 1 NC_014215.1 ATP + D-Xylulose <=> ADP + D-Xylulose 5-phosphate; xylulokinase 102252 xylB 9283358 xylB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 xylulokinase YP_003687039.1 100696 D 754252 CDS YP_003687040.1 297625277 9284482 102305..103357 1 NC_014215.1 sn-glycerol 3-phosphate + NAD+ <=> glycerone phosphate + NADH + H+ / sn-glycerol 3-phosphate + NADP+ <=> glycerone phosphate + NADPH + H+; glycerol-3-phosphate dehydrogenase [NAD(P)+] 103357 gpsA 9284482 gpsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerol-3-phosphate dehydrogenase [NAD(P)+] YP_003687040.1 102305 D 754252 CDS YP_003687041.1 297625278 9283657 103431..104207 1 NC_014215.1 transcriptional regulator 104207 deoR1 9283657 deoR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687041.1 103431 D 754252 CDS YP_003687042.1 297625279 9283487 104640..105638 1 NC_014215.1 3-methyladenine DNA glycosylase 105638 alkA 9283487 alkA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-methyladenine DNA glycosylase YP_003687042.1 104640 D 754252 CDS YP_003687043.1 297625280 9283309 105638..106897 1 NC_014215.1 MFS protein 106897 9283309 PFREUD_00800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MFS protein YP_003687043.1 105638 D 754252 CDS YP_003687044.1 297625281 9282057 complement(106926..108353) 1 NC_014215.1 ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.; histidine kinase sensor protein 108353 9282057 PFREUD_00810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 histidine kinase sensor protein YP_003687044.1 106926 R 754252 CDS YP_003687045.1 297625282 9282058 complement(108350..109045) 1 NC_014215.1 two-component response regulator 109045 9282058 PFREUD_00820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component response regulator YP_003687045.1 108350 R 754252 CDS YP_003687046.1 297625283 9282059 complement(109052..109966) 1 NC_014215.1 In bacteria peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly.; peptidase E 109966 9282059 PFREUD_00830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase E YP_003687046.1 109052 R 754252 CDS YP_003687047.1 297625284 9282060 complement(110022..110486) 1 NC_014215.1 protein tyrosine phosphate + H2O <=> protein tyrosine + Orthophosphate; protein-tyrosine-phosphatase 110486 ptpA 9282060 ptpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein-tyrosine-phosphatase YP_003687047.1 110022 R 754252 CDS YP_003687048.1 297625285 9284136 complement(110483..110863) 1 NC_014215.1 hypothetical protein 110863 9284136 PFREUD_00850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687048.1 110483 R 754252 CDS YP_003687049.1 297625286 9282061 111002..112006 1 NC_014215.1 carbamoyl phosphate + L-Ornithine <=> Orthophosphate + L-Citrulline; ornithine carbamoyltransferase 112006 argF 9282061 argF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ornithine carbamoyltransferase YP_003687049.1 111002 D 754252 CDS YP_003687050.1 297625287 9283331 112010..112609 1 NC_014215.1 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. Required for DNA damage lesion repair in stationary-phase cells; G/U mismatch-specific DNA glycosylase 112609 mug 9283331 mug Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 G/U mismatch-specific DNA glycosylase YP_003687050.1 112010 D 754252 CDS YP_003687051.1 297625288 9283915 112893..113681 1 NC_014215.1 oxidoreductase 113681 noxB 9283915 noxB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 oxidoreductase YP_003687051.1 112893 D 754252 CDS YP_003687052.1 297625289 9283956 113648..115003 1 NC_014215.1 transposase 115003 tnpA 9283956 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687052.1 113648 D 754252 CDS YP_003687053.1 297625290 9284353 114858..115205 1 NC_014215.1 hypothetical protein 115205 9284353 PFREUD_00890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687053.1 114858 D 754252 CDS YP_003687054.1 297625291 9282062 complement(115228..116322) 1 NC_014215.1 tRNA processing ribonuclease BN 116322 9282062 PFREUD_00900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA processing ribonuclease BN YP_003687054.1 115228 R 754252 CDS YP_003687055.1 297625292 9282063 complement(116385..116948) 1 NC_014215.1 hypothetical protein 116948 9282063 PFREUD_00910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687055.1 116385 R 754252 CDS YP_003687056.1 297625293 9282064 complement(116945..117106) 1 NC_014215.1 hypothetical protein 117106 9282064 PFREUD_00920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687056.1 116945 R 754252 CDS YP_003687057.1 297625294 9282065 117132..118241 1 NC_014215.1 hypothetical protein 118241 9282065 PFREUD_00930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687057.1 117132 D 754252 CDS YP_003687058.1 297625295 9282066 complement(118259..118624) 1 NC_014215.1 hypothetical protein 118624 9282066 PFREUD_00940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687058.1 118259 R 754252 CDS YP_003687059.1 297625296 9283649 complement(119045..119770) 1 NC_014215.1 stomatin/prohibitin 119770 hflC1 9283649 hflC1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 stomatin/prohibitin YP_003687059.1 119045 R 754252 CDS YP_003687060.1 297625297 9283698 complement(119944..120813) 1 NC_014215.1 no peptide signal, 3 TM domains according to TMHMM; hypothetical protein 120813 9283698 PFREUD_00970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687060.1 119944 R 754252 CDS YP_003687061.1 297625298 9282068 complement(120818..123085) 1 NC_014215.1 Reduced acceptor + 2 Nitric oxide <=> Nitrous oxide + Acceptor + H2O / Nitric oxide + NADH + H+ <=> Nitrous oxide + NAD+ + H2O; nitric-oxide reductase subunit B 123085 norB 9282068 norB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nitric-oxide reductase subunit B YP_003687061.1 120818 R 754252 CDS YP_003687062.1 297625299 9283955 complement(122947..123879) 1 NC_014215.1 L-Leucyl-tRNA + protein <=> tRNA + L-Leucyl-protein; leucyl/phenylalanyl-tRNA-protein transferase 123879 aatA 9283955 aatA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 leucyl/phenylalanyl-tRNA-protein transferase YP_003687062.1 122947 R 754252 CDS YP_003687064.1 297625301 9282069 complement(123962..124159) 1 NC_014215.1 hypothetical protein 124159 9282069 PFREUD_01010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687064.1 123962 R 754252 CDS YP_003687065.1 297625302 9282070 124247..124552 1 NC_014215.1 transposase IS3/IS911 124552 tnpC 9282070 tnpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687065.1 124247 D 754252 CDS YP_003687066.1 297625303 9284401 124549..125457 1 NC_014215.1 integrase 125457 int 9284401 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687066.1 124549 D 754252 CDS YP_003687068.1 297625305 9284355 complement(126139..127026) 1 NC_014215.1 transposase 127026 tnpB 9284355 tnpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687068.1 126139 R 754252 CDS YP_003687069.1 297625306 9284395 complement(127059..127403) 1 NC_014215.1 transposase IS3/IS911 127403 TnpD 9284395 TnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687069.1 127059 R 754252 CDS YP_003687070.1 297625307 9284406 complement(127442..128350) 1 NC_014215.1 integrase 128350 int 9284406 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687070.1 127442 R 754252 CDS YP_003687071.1 297625308 9283763 complement(128347..128652) 1 NC_014215.1 transposase IS3/IS911 128652 tnpC 9283763 tnpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687071.1 128347 R 754252 CDS YP_003687072.1 297625309 9284402 complement(129036..129842) 1 NC_014215.1 hypothetical protein 129842 9284402 PFREUD_01030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687072.1 129036 R 754252 CDS YP_003687073.1 297625310 9282072 complement(130020..131555) 1 NC_014215.1 ATP + D-gluconic acid <=> ADP + 6-phospho-D-gluconate; gluconate kinase 131555 gntK 9282072 gntK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 gluconate kinase YP_003687073.1 130020 R 754252 CDS YP_003687074.1 297625311 9283650 complement(131814..132677) 1 NC_014215.1 formamidopyrimidine-DNA glycosylase 132677 mutM1 9283650 mutM1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 formamidopyrimidine-DNA glycosylase YP_003687074.1 131814 R 754252 CDS YP_003687075.1 297625312 9283927 complement(132670..133395) 1 NC_014215.1 L-Leucyl-tRNA + protein <=> tRNA + L-Leucyl-protein; leucyl/phenylalanyl-tRNA-protein transferase 133395 aatB 9283927 aatB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 leucyl/phenylalanyl-tRNA-protein transferase YP_003687075.1 132670 R 754252 CDS YP_003687076.1 297625313 9283286 complement(133942..136128) 1 NC_014215.1 ATP + protein <=> ADP + phosphoprotein; serine/threonine protein kinase 136128 pkaA 9283286 pkaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 serine/threonine protein kinase YP_003687076.1 133942 R 754252 CDS YP_003687077.1 297625314 9284077 complement(136443..137051) 1 NC_014215.1 transglycosylase 137051 9284077 PFREUD_01080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transglycosylase YP_003687077.1 136443 R 754252 CDS YP_003687078.1 297625315 9282073 complement(137263..138567) 1 NC_014215.1 Citrate + CoA <=> acetyl-CoA + H2O + Oxaloacetate; citrate synthase 138567 gltA2 9282073 gltA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 citrate synthase YP_003687078.1 137263 R 754252 CDS YP_003687079.1 297625316 9283636 139026..139829 1 NC_014215.1 hypothetical protein 139829 9283636 PFREUD_01100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687079.1 139026 D 754252 CDS YP_003687080.1 297625317 9282074 complement(139940..140809) 1 NC_014215.1 hypothetical protein 140809 9282074 PFREUD_01110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687080.1 139940 R 754252 CDS YP_003687081.1 297625318 9282075 complement(140988..142493) 1 NC_014215.1 Subtilases are a family of serine proteases.; peptidase subtilase 142493 vpr 9282075 vpr Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase subtilase YP_003687081.1 140988 R 754252 CDS YP_003687082.1 297625319 9284472 complement(142614..143762) 1 NC_014215.1 L-alanine <=> D-alanine; alanine racemase 143762 alr 9284472 alr Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alanine racemase YP_003687082.1 142614 R 754252 CDS YP_003687083.1 297625320 9283310 complement(143935..145488) 1 NC_014215.1 hypothetical protein 145488 9283310 PFREUD_01140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687083.1 143935 R 754252 CDS YP_003687084.1 297625321 9282076 complement(145532..145876) 1 NC_014215.1 ArsR family transcriptional regulator 145876 arsR1 9282076 arsR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003687084.1 145532 R 754252 CDS YP_003687085.1 297625322 9283957 146609..146683 1 NC_014215.1 hypothetical protein 146683 9283957 PFREUD_01170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687085.1 146609 D 754252 CDS YP_003687086.1 297625323 9282077 146650..147957 1 NC_014215.1 transposase 147957 tnpA 9282077 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687086.1 146650 D 754252 CDS YP_003687087.1 297625324 9284358 complement(148571..149509) 1 NC_014215.1 restriction endonuclease PvuRts1 I 149509 9284358 PFREUD_01180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 restriction endonuclease PvuRts1 I YP_003687087.1 148571 R 754252 CDS YP_003687088.1 297625325 9282078 complement(149691..149897) 1 NC_014215.1 hypothetical protein 149897 9282078 PFREUD_01190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687088.1 149691 R 754252 CDS YP_003687089.1 297625326 9282079 complement(149916..150023) 1 NC_014215.1 hypothetical protein 150023 9282079 PFREUD_01200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687089.1 149916 R 754252 CDS YP_003687090.1 297625327 9284359 150653..150997 1 NC_014215.1 transposase IS3/IS911 150997 TnpD 9284359 TnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687090.1 150653 D 754252 CDS YP_003687091.1 297625328 9284407 151030..151917 1 NC_014215.1 transposase 151917 tnpB 9284407 tnpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687091.1 151030 D 754252 CDS YP_003687092.1 297625329 9284396 152007..152960 1 NC_014215.1 may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes.; ADP-ribose-1-monophosphate 152960 9284396 PFREUD_01210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ADP-ribose-1-monophosphate YP_003687092.1 152007 D 754252 CDS YP_003687093.1 297625330 9282081 complement(153075..154643) 1 NC_014215.1 DNA polymerase 154643 9282081 PFREUD_01220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase YP_003687093.1 153075 R 754252 CDS YP_003687094.1 297625331 9283722 complement(158339..158617) 1 NC_014215.1 methylase S, type I restriction enzyme 158617 9283722 PFREUD_01250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylase S, type I restriction enzyme YP_003687094.1 158339 R 754252 CDS YP_003687095.1 297625332 9282083 complement(159010..160578) 1 NC_014215.1 type I restriction-modification system DNA methylase 160578 hsdM1 9282083 hsdM1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 type I restriction-modification system DNA methylase YP_003687095.1 159010 R 754252 CDS YP_003687096.1 297625333 9283719 complement(160633..162456) 1 NC_014215.1 ABC transporter ATP-binding protein 162456 9283719 PFREUD_01270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687096.1 160633 R 754252 CDS YP_003687097.1 297625334 9282084 complement(162453..163652) 1 NC_014215.1 ABC transporter permease 163652 9282084 PFREUD_01280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687097.1 162453 R 754252 CDS YP_003687098.1 297625335 9282085 complement(163854..164843) 1 NC_014215.1 (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+; 2-dehydropantoate 2-reductase 164843 panE1 9282085 panE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-dehydropantoate 2-reductase YP_003687098.1 163854 R 754252 CDS YP_003687099.1 297625336 9283996 165075..166814 1 NC_014215.1 para-aminobenzoate synthase 166814 PPA1976 9283996 PPA1976 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 para-aminobenzoate synthase YP_003687099.1 165075 D 754252 CDS YP_003687100.1 297625337 9284103 166657..167760 1 NC_014215.1 hypothetical protein 167760 9284103 PFREUD_01310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687100.1 166657 D 754252 CDS YP_003687101.1 297625338 9282086 complement(168053..168733) 1 NC_014215.1 hypothetical protein 168733 9282086 PFREUD_01320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687101.1 168053 R 754252 CDS YP_003687102.1 297625339 9282087 169344..170330 1 NC_014215.1 L-Arogenate <=> L-Phenylalanine + H2O + CO2 and Prephenate <=> Phenylpyruvate + H2O + CO2; prephenate dehydratase 170330 pheA 9282087 pheA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 prephenate dehydratase YP_003687102.1 169344 D 754252 CDS YP_003687103.1 297625340 9284066 complement(170210..171814) 1 NC_014215.1 diacylglycerol kinase 171814 9284066 PFREUD_01340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 diacylglycerol kinase YP_003687103.1 170210 R 754252 CDS YP_003687104.1 297625341 9282088 171962..173236 1 NC_014215.1 ATP + L-serine + tRNA(Ser) <=> AMP + Pyrophosphate + L-Seryl-tRNA(Ser); seryl-tRNA synthetase 173236 serS1 9282088 serS1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 seryl-tRNA synthetase YP_003687104.1 171962 D 754252 CDS YP_003687105.1 297625342 9284279 173357..174037 1 NC_014215.1 hypothetical protein 174037 9284279 PFREUD_01360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687105.1 173357 D 754252 CDS YP_003687106.1 297625343 9282089 complement(174082..174180) 1 NC_014215.1 hypothetical protein 174180 9282089 PFREUD_01370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687106.1 174082 R 754252 CDS YP_003687107.1 297625344 9282090 complement(174177..177149) 1 NC_014215.1 PTS system mannose-specific EIIBCA component 177149 ptsG/ptsM 9282090 ptsG/ptsM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PTS system mannose-specific EIIBCA component YP_003687107.1 174177 R 754252 CDS YP_003687108.1 297625345 9284137 177399..178793 1 NC_014215.1 exonuclease 178793 9284137 PFREUD_01390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exonuclease YP_003687108.1 177399 D 754252 CDS YP_003687109.1 297625346 9282091 178790..179509 1 NC_014215.1 transcriptional regulator 179509 9282091 PFREUD_01400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687109.1 178790 D 754252 CDS YP_003687110.1 297625347 9282092 179674..180795 1 NC_014215.1 ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.; histidine kinase 180795 9282092 PFREUD_01410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 histidine kinase YP_003687110.1 179674 D 754252 CDS YP_003687111.1 297625348 9282093 complement(180857..181504) 1 NC_014215.1 hypothetical protein 181504 9282093 PFREUD_01420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687111.1 180857 R 754252 CDS YP_003687112.1 297625349 9282094 181865..182362 1 NC_014215.1 peroxydase. Has antioxidant activity. Could remove peroxides or H(2)O(2); thiol peroxidase 182362 tpx 9282094 tpx Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiol peroxidase YP_003687112.1 181865 D 754252 CDS YP_003687113.1 297625350 9284417 complement(182530..183276) 1 NC_014215.1 Modulates the activities of several enzymes which are inactive in their acetylated form. NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein; Silent information regulator protein Sir2 /NAD-dependent deacetylase 183276 npdA 9284417 npdA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Silent information regulator protein Sir2 /NAD-dependent deacetylase YP_003687113.1 182530 R 754252 CDS YP_003687114.1 297625351 9283958 183477..185186 1 NC_014215.1 transcriptional regulator 185186 cpsA1 9283958 cpsA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687114.1 183477 D 754252 CDS YP_003687115.1 297625352 9283445 complement(185841..187277) 1 NC_014215.1 ATP + L-Citrulline + L-aspartate <=> AMP + Pyrophosphate + N-(L-arginino)succinate; argininosuccinate synthase 187277 argG 9283445 argG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 argininosuccinate synthase YP_003687115.1 185841 R 754252 CDS YP_003687116.1 297625353 9283332 complement(187439..188410) 1 NC_014215.1 NADPH:quinone reductase 188410 9283332 PFREUD_01470 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADPH:quinone reductase YP_003687116.1 187439 R 754252 CDS YP_003687117.1 297625354 9282096 188660..189097 1 NC_014215.1 hypothetical protein 189097 9282096 PFREUD_01490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687117.1 188660 D 754252 CDS YP_003687118.1 297625355 9282097 complement(189479..192067) 1 NC_014215.1 transcriptional regulator 192067 9282097 PFREUD_01500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687118.1 189479 R 754252 CDS YP_003687119.1 297625356 9282098 189510..189719 1 NC_014215.1 hypothetical protein 189719 9282098 PFREUD_01510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687119.1 189510 D 754252 CDS YP_003687120.1 297625357 9282101 complement(193036..193290) 1 NC_014215.1 hypothetical protein 193290 9282101 PFREUD_01540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687120.1 193036 R 754252 CDS YP_003687121.1 297625358 9282102 complement(193244..194332) 1 NC_014215.1 confers low-level resistance to the glycopeptide antibiotic teicoplanin (Te)Arthur M, Depardieu F, Molinas C, Reynolds P, Courvalin P; , Gene 1995;154:87-92.: The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin.; VanZ 194332 vanZ 9282102 vanZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 VanZ YP_003687121.1 193244 R 754252 CDS YP_003687122.1 297625359 9284471 194524..195207 1 NC_014215.1 Short-subunit alcohol dehydrogenase of unknown specificity; short subunit dehydrogenase 195207 9284471 PFREUD_01560 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 short subunit dehydrogenase YP_003687122.1 194524 D 754252 CDS YP_003687123.1 297625360 9282103 195204..195923 1 NC_014215.1 glycerophosphodiester + H2O <=> Alcohol + sn-glycerol 3-phosphate; glycerophosphoryl diester phosphodiesterase 195923 ugpQ1 9282103 ugpQ1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerophosphoryl diester phosphodiesterase YP_003687123.1 195204 D 754252 CDS YP_003687124.1 297625361 9284452 complement(196022..196840) 1 NC_014215.1 Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ and Shikimate + NADP+ <=> 5-Dehydroshikimate + NADPH; shikimate 5-dehydrogenase 196840 aroE 9284452 aroE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 shikimate 5-dehydrogenase YP_003687124.1 196022 R 754252 CDS YP_003687125.1 297625362 9283341 196927..197976 1 NC_014215.1 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate Benzoate degradation via hydroxylation; 3-carboxymuconate cyclase 197976 9283341 PFREUD_01590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-carboxymuconate cyclase YP_003687125.1 196927 D 754252 CDS YP_003687126.1 297625363 9282104 198081..198923 1 NC_014215.1 involved in ascorbate production 2-Dehydro-D-gluconate + NADP+ <=> 2,5-Didehydro-D-gluconate + NADPH + H+; 2,5-diketo-D-gluconate reductase A 198923 dkgA 9282104 dkgA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2,5-diketo-D-gluconate reductase A YP_003687126.1 198081 D 754252 CDS YP_003687127.1 297625364 9283502 complement(199077..201533) 1 NC_014215.1 lipid transport ?; ABC transporter permease 201533 9283502 PFREUD_01610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687127.1 199077 R 754252 CDS YP_003687128.1 297625365 9282105 complement(201533..202411) 1 NC_014215.1 ABC transporter ATP-binding protein 202411 9282105 PFREUD_01620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687128.1 201533 R 754252 CDS YP_003687129.1 297625366 9282106 complement(202689..203399) 1 NC_014215.1 LuxR family transcriptional regulator 203399 9282106 PFREUD_01630 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LuxR family transcriptional regulator YP_003687129.1 202689 R 754252 CDS YP_003687130.1 297625367 9282107 complement(203365..204687) 1 NC_014215.1 two component sensor kinase 204687 9282107 PFREUD_01640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two component sensor kinase YP_003687130.1 203365 R 754252 CDS YP_003687131.1 297625368 9282108 complement(204833..205435) 1 NC_014215.1 hypothetical protein 205435 9282108 PFREUD_01650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687131.1 204833 R 754252 CDS YP_003687132.1 297625369 9282109 205658..206263 1 NC_014215.1 hypothetical protein 206263 9282109 PFREUD_01660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687132.1 205658 D 754252 CDS YP_003687133.1 297625370 9282110 206513..206740 1 NC_014215.1 acetyltransferase 206740 9282110 PFREUD_01670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003687133.1 206513 D 754252 CDS YP_003687134.1 297625371 9282111 206829..207062 1 NC_014215.1 hypothetical protein 207062 9282111 PFREUD_01680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687134.1 206829 D 754252 CDS YP_003687135.1 297625372 9282112 complement(207196..207570) 1 NC_014215.1 peptidyl-prolyl cis-trans isomerase 207570 fkbP 9282112 fkbP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidyl-prolyl cis-trans isomerase YP_003687135.1 207196 R 754252 CDS YP_003687136.1 297625373 9283563 complement(207567..208265) 1 NC_014215.1 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway.; pantothenate kinase 208265 CoA 9283563 CoA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pantothenate kinase YP_003687136.1 207567 R 754252 CDS YP_003687137.1 297625374 9283428 208418..209029 1 NC_014215.1 exonuclease 209029 9283428 PFREUD_01710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exonuclease YP_003687137.1 208418 D 754252 CDS YP_003687138.1 297625375 9282113 209381..210883 1 NC_014215.1 cytochrome d ubiquinol oxidase subunit I 210883 cydA 9282113 cydA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cytochrome d ubiquinol oxidase subunit I YP_003687138.1 209381 D 754252 CDS YP_003687139.1 297625376 9283453 210900..212033 1 NC_014215.1 cytochrome D ubiquinol oxidase subunit II 212033 cydB 9283453 cydB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cytochrome D ubiquinol oxidase subunit II YP_003687139.1 210900 D 754252 CDS YP_003687140.1 297625377 9283454 212057..215701 1 NC_014215.1 ABC transporter 215701 cydCD 9283454 cydCD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687140.1 212057 D 754252 CDS YP_003687141.1 297625378 9283455 complement(216139..217425) 1 NC_014215.1 N-Succinyl-LL-2,6-diaminoheptanedioate + H2O <=> succinate + LL-2,6-diaminoheptanedioate; acetylornithine deacetylase 217425 dapE1 9283455 dapE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetylornithine deacetylase YP_003687141.1 216139 R 754252 CDS YP_003687142.1 297625379 9283478 complement(216240..216365) 1 NC_014215.1 Pfam domain; peptidase 216365 9283478 PFREUD_01760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase YP_003687142.1 216240 R 754252 CDS YP_003687143.1 297625380 9282114 216412..216492 1 NC_014215.1 hypothetical protein 216492 9282114 PFREUD_01770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687143.1 216412 D 754252 CDS YP_003687144.1 297625381 9282115 complement(217560..219257) 1 NC_014215.1 ABC transporter permease 219257 9282115 PFREUD_01780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687144.1 217560 R 754252 CDS YP_003687145.1 297625382 9282116 complement(219711..219860) 1 NC_014215.1 hypothetical protein 219860 9282116 PFREUD_01790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687145.1 219711 R 754252 CDS YP_003687146.1 297625383 9282117 complement(219839..220333) 1 NC_014215.1 TetR family transcriptional regulator 220333 tetR2 9282117 tetR2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003687146.1 219839 R 754252 CDS YP_003687147.1 297625384 9284321 220537..220854 1 NC_014215.1 hypothetical protein 220854 9284321 PFREUD_01810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687147.1 220537 D 754252 CDS YP_003687149.1 297625386 9282119 221178..222809 1 NC_014215.1 FAD-dependent pyridine nucleotide-disulfide oxidoreductase 222809 9282119 PFREUD_01830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FAD-dependent pyridine nucleotide-disulfide oxidoreductase YP_003687149.1 221178 D 754252 CDS YP_003687150.1 297625387 9282120 222815..226582 1 NC_014215.1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase , pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin; pyruvate synthase/pyruvate-flavodoxin oxidoreductase 226582 nifJ1 9282120 nifJ1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyruvate synthase/pyruvate-flavodoxin oxidoreductase YP_003687150.1 222815 D 754252 CDS YP_003687151.1 297625388 9283949 226575..227732 1 NC_014215.1 (S)-dihydroorotate + Oxygen <=> Orotate + H2O2; dihydroorotate dehydrogenase 227732 9283949 PFREUD_01850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroorotate dehydrogenase YP_003687151.1 226575 D 754252 CDS YP_003687152.1 297625389 9282121 complement(227992..229416) 1 NC_014215.1 betaine-aldehyde dehydrogenase 229416 dha1 9282121 dha1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 betaine-aldehyde dehydrogenase YP_003687152.1 227992 R 754252 CDS YP_003687153.1 297625390 9283492 229967..230266 1 NC_014215.1 hypothetical protein 230266 9283492 PFREUD_01870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687153.1 229967 D 754252 CDS YP_003687155.1 297625392 9282123 230301..230510 1 NC_014215.1 hypothetical protein 230510 9282123 PFREUD_01890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687155.1 230301 D 754252 CDS YP_003687156.1 297625393 9282124 230582..230716 1 NC_014215.1 hypothetical protein 230716 9282124 PFREUD_01900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687156.1 230582 D 754252 CDS YP_003687157.1 297625394 9282125 230802..231002 1 NC_014215.1 hypothetical protein 231002 9282125 PFREUD_01910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687157.1 230802 D 754252 CDS YP_003687158.1 297625395 9282126 231284..231904 1 NC_014215.1 hypothetical protein 231904 9282126 PFREUD_01920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687158.1 231284 D 754252 CDS YP_003687159.1 297625396 9282127 231901..232857 1 NC_014215.1 hypothetical protein 232857 9282127 PFREUD_01930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687159.1 231901 D 754252 CDS YP_003687160.1 297625397 9282128 complement(233088..234377) 1 NC_014215.1 voir cd01189; site-specific recombinase 234377 int 9282128 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 site-specific recombinase YP_003687160.1 233088 R 754252 CDS YP_003687161.1 297625398 9283750 complement(234408..234902) 1 NC_014215.1 hypothetical protein 234902 9283750 PFREUD_01950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687161.1 234408 R 754252 CDS YP_003687162.1 297625399 9282129 235090..235200 1 NC_014215.1 hypothetical protein 235200 9282129 PFREUD_01960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687162.1 235090 D 754252 CDS YP_003687163.1 297625400 9282130 235383..236693 1 NC_014215.1 filamentation induced by cAMP protein . Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members.; Fic protein 236693 fic 9282130 fic Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fic protein YP_003687163.1 235383 D 754252 CDS YP_003687164.1 297625401 9283556 236707..237306 1 NC_014215.1 methyltransferase 237306 9283556 PFREUD_01980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003687164.1 236707 D 754252 CDS YP_003687165.1 297625402 9284419 240955..241347 1 NC_014215.1 hypothetical protein 241347 9284419 PFREUD_02010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687165.1 240955 D 754252 CDS YP_003687166.1 297625403 9282132 241388..241795 1 NC_014215.1 hypothetical protein 241795 9282132 PFREUD_02020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687166.1 241388 D 754252 CDS YP_003687167.1 297625404 9282133 complement(241799..242242) 1 NC_014215.1 hypothetical protein 242242 9282133 PFREUD_02030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687167.1 241799 R 754252 CDS YP_003687168.1 297625405 9282134 242316..242981 1 NC_014215.1 hypothetical protein 242981 9282134 PFREUD_02040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687168.1 242316 D 754252 CDS YP_003687169.1 297625406 9282135 242978..243550 1 NC_014215.1 RNA polymerase, sigma-24 subunit, ECF subfamily RpoE 243550 rpoD 9282135 rpoD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RNA polymerase, sigma-24 subunit, ECF subfamily RpoE YP_003687169.1 242978 D 754252 CDS YP_003687170.1 297625407 9284232 complement(243962..244417) 1 NC_014215.1 MarR family transcriptional regulator 244417 mar 9284232 mar Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MarR family transcriptional regulator YP_003687170.1 243962 R 754252 CDS YP_003687171.1 297625408 9283857 244513..245148 1 NC_014215.1 This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.; NAD-dependent epimerase/dehydratase 245148 9283857 PFREUD_02070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NAD-dependent epimerase/dehydratase YP_003687171.1 244513 D 754252 CDS YP_003687172.1 297625409 9282136 245166..246065 1 NC_014215.1 AraC family transcriptional regulator 246065 araC1 9282136 araC1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 AraC family transcriptional regulator YP_003687172.1 245166 D 754252 CDS YP_003687173.1 297625410 9283322 complement(246357..248420) 1 NC_014215.1 ABC transporter 248420 9283322 PFREUD_02090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687173.1 246357 R 754252 CDS YP_003687174.1 297625411 9282137 complement(248417..250150) 1 NC_014215.1 ABC transporter 250150 9282137 PFREUD_02100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687174.1 248417 R 754252 CDS YP_003687175.1 297625412 9282138 complement(250150..250842) 1 NC_014215.1 transcriptional regulator 250842 9282138 PFREUD_02110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687175.1 250150 R 754252 CDS YP_003687176.1 297625413 9282139 complement(250920..251810) 1 NC_014215.1 2-amino-4-hydroxy-6-hydroxymethyl-7, 8-dihydropteridine + 4-aminobenzoate <=> dihydropteroate + H2O / 2-amino-7, 8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-aminobenzoate <=> Pyrophosphate + dihydropteroate; dihydropteroate synthase 251810 folP1 9282139 folP1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydropteroate synthase YP_003687176.1 250920 R 754252 CDS YP_003687177.1 297625414 9283572 252063..253565 1 NC_014215.1 permease 253565 proY 9283572 proY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 permease YP_003687177.1 252063 D 754252 CDS YP_003687178.1 297625415 9284124 253702..254088 1 NC_014215.1 hypothetical protein 254088 9284124 PFREUD_02140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687178.1 253702 D 754252 CDS YP_003687179.1 297625416 9282140 254360..255019 1 NC_014215.1 methyltransferase 255019 9282140 PFREUD_02150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003687179.1 254360 D 754252 CDS YP_003687180.1 297625417 9282141 255309..257003 1 NC_014215.1 ABC transporter ATP-binding protein 257003 9282141 PFREUD_02160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687180.1 255309 D 754252 CDS YP_003687181.1 297625418 9282142 257147..258754 1 NC_014215.1 ATP + L-lysine + tRNA(Lys) <=> AMP + Pyrophosphate + L-Lysyl-tRNA; lysyl-tRNA synthetase 258754 lysS 9282142 lysS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lysyl-tRNA synthetase YP_003687181.1 257147 D 754252 CDS YP_003687182.1 297625419 9283845 complement(258940..259662) 1 NC_014215.1 methyltransferase 259662 9283845 PFREUD_02180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003687182.1 258940 R 754252 CDS YP_003687183.1 297625420 9282143 259807..260919 1 NC_014215.1 Similar to Swiss-Prot entries Q9I1M2 and P09060; 2-oxoisovalerate dehydrogenase subunit alpha 260919 bkdA1 9282143 bkdA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-oxoisovalerate dehydrogenase subunit alpha YP_003687183.1 259807 D 754252 CDS YP_003687184.1 297625421 9283379 260916..261890 1 NC_014215.1 44% identity with Swiss-Prot entry P09061; 2-oxoisovalerate dehydrogenase subunit beta 261890 bkdA2 9283379 bkdA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-oxoisovalerate dehydrogenase subunit beta YP_003687184.1 260916 D 754252 CDS YP_003687185.1 297625422 9283380 261901..263247 1 NC_014215.1 Similarity to Swiss-Prot entry Q9IMO; dihydrolipoamide branched-subunit transacylase 263247 bkdB 9283380 bkdB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrolipoamide branched-subunit transacylase YP_003687185.1 261901 D 754252 CDS YP_003687186.1 297625423 9283381 complement(263473..264507) 1 NC_014215.1 hypothetical protein 264507 9283381 PFREUD_02220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687186.1 263473 R 754252 CDS YP_003687187.1 297625424 9282144 complement(264823..265110) 1 NC_014215.1 hypothetical protein 265110 whiP 9282144 whiP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687187.1 264823 R 754252 CDS YP_003687188.1 297625425 9284476 265289..266023 1 NC_014215.1 hypothetical protein 266023 9284476 PFREUD_02240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687188.1 265289 D 754252 CDS YP_003687189.1 297625426 9282145 266136..266780 1 NC_014215.1 Chorismate + NH3 <=> Anthranilate + pyruvate + H2O Chorismate + L-glutamine <=> Anthranilate + pyruvate + L-glutamate; glutamine amidotransferase 266780 pabA 9282145 pabA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine amidotransferase YP_003687189.1 266136 D 754252 CDS YP_003687190.1 297625427 9283992 complement(266822..267676) 1 NC_014215.1 aldo/keto reductase 267676 9283992 PFREUD_02260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aldo/keto reductase YP_003687190.1 266822 R 754252 CDS YP_003687191.1 297625428 9282146 complement(267796..268317) 1 NC_014215.1 hypothetical protein 268317 9282146 PFREUD_02270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687191.1 267796 R 754252 CDS YP_003687192.1 297625429 9282147 complement(268513..268884) 1 NC_014215.1 hypothetical protein 268884 9282147 PFREUD_02280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687192.1 268513 R 754252 CDS YP_003687193.1 297625430 9282148 complement(269199..272594) 1 NC_014215.1 hypothetical protein 272594 9282148 PFREUD_02290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687193.1 269199 R 754252 CDS YP_003687194.1 297625431 9282149 272752..273492 1 NC_014215.1 hypothetical protein 273492 9282149 PFREUD_02300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687194.1 272752 D 754252 CDS YP_003687195.1 297625432 9282150 complement(273496..274938) 1 NC_014215.1 secreted serine protease, trypsin-like serine proteases 274938 htrA2 9282150 htrA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 secreted serine protease, trypsin-like serine proteases YP_003687195.1 273496 R 754252 CDS YP_003687196.1 297625433 9283730 complement(275491..276855) 1 NC_014215.1 Trypsin-like serine protease 276855 htrA3 9283730 htrA3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Trypsin-like serine protease YP_003687196.1 275491 R 754252 CDS YP_003687197.1 297625434 9283731 277112..277417 1 NC_014215.1 transposase IS3/IS911 277417 tnpC 9283731 tnpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687197.1 277112 D 754252 CDS YP_003687198.1 297625435 9284403 277414..278322 1 NC_014215.1 integrase 278322 int 9284403 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687198.1 277414 D 754252 CDS YP_003687199.1 297625436 9283764 complement(278836..280191) 1 NC_014215.1 Hg + NADP+ + H+ <=> Hg2+ + NADPH; pyridine nucleotide-disulfide oxidoreductase 280191 merA 9283764 merA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyridine nucleotide-disulfide oxidoreductase YP_003687199.1 278836 R 754252 CDS YP_003687200.1 297625437 9283871 complement(280341..281759) 1 NC_014215.1 integrase 281759 int 9283871 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687200.1 280341 R 754252 CDS YP_003687201.1 297625438 9283765 complement(281906..283213) 1 NC_014215.1 transposase 283213 tnpA 9283765 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687201.1 281906 R 754252 CDS YP_003687202.1 297625439 9284360 complement(283180..283254) 1 NC_014215.1 hypothetical protein 283254 9284360 PFREUD_02340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687202.1 283180 R 754252 CDS YP_003687203.1 297625440 9282151 complement(283456..284451) 1 NC_014215.1 UDP-glucose = UDP-galactose; UDP-glucose 4-epimerase 284451 galE1 9282151 galE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-glucose 4-epimerase YP_003687203.1 283456 R 754252 CDS YP_003687204.1 297625441 9283592 complement(284497..285885) 1 NC_014215.1 Sodium:galactoside symporter 285885 galP 9283592 galP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sodium:galactoside symporter YP_003687204.1 284497 R 754252 CDS YP_003687205.1 297625442 9283597 complement(285908..288976) 1 NC_014215.1 Lactose + H2O <=> alpha-D-glucose + D-Galactose; beta-galactosidase 288976 lacZ 9283597 lacZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-galactosidase YP_003687205.1 285908 R 754252 CDS YP_003687206.1 297625443 9283924 289289..290278 1 NC_014215.1 transcriptional regulator 290278 9283924 PFREUD_02390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687206.1 289289 D 754252 CDS YP_003687207.1 297625444 9282152 complement(290240..291073) 1 NC_014215.1 integrase core domain. integrase mediates integration of a DNA copy of the viral genome into the host chromosome.; integrase 291073 int 9282152 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687207.1 290240 R 754252 CDS YP_003687208.1 297625445 9283766 290327..290506 1 NC_014215.1 hypothetical protein 290506 9283766 PFREUD_02400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687208.1 290327 D 754252 CDS YP_003687209.1 297625446 9282153 290427..290513 1 NC_014215.1 hypothetical protein 290513 9282153 PFREUD_02410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687209.1 290427 D 754252 CDS YP_003687210.1 297625447 9282154 complement(291097..291420) 1 NC_014215.1 transposase IS3/IS911 291420 tnp 9282154 tnp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687210.1 291097 R 754252 CDS YP_003687211.1 297625448 9284346 291647..292783 1 NC_014215.1 fatty acid metabolism and xenobiotic degradation; crotonobetainyl-CoA dehydrogenase 292783 caiA 9284346 caiA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 crotonobetainyl-CoA dehydrogenase YP_003687211.1 291647 D 754252 CDS YP_003687212.1 297625449 9283388 292853..294079 1 NC_014215.1 Engemann et al. Cai locus and corresponding enzymes of Proteus sp.; crotonobetainyl-CoA:carnitine CoA-transferase 294079 caiB 9283388 caiB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 crotonobetainyl-CoA:carnitine CoA-transferase YP_003687212.1 292853 D 754252 CDS YP_003687213.1 297625450 9283389 294104..295705 1 NC_014215.1 Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the caiB reaction cycle; crotonobetaine/carnitine-CoA ligase 295705 caiC 9283389 caiC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 crotonobetaine/carnitine-CoA ligase YP_003687213.1 294104 D 754252 CDS YP_003687214.1 297625451 9283390 295702..296580 1 NC_014215.1 MaoC acyl dehydratase 296580 maoC 9283390 maoC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MaoC acyl dehydratase YP_003687214.1 295702 D 754252 CDS YP_003687215.1 297625452 9283854 296791..298149 1 NC_014215.1 Belongs to the major facilitator superfamily. Sugar transporter; metabolite transport protein YaaU 298149 yaaU 9283854 yaaU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metabolite transport protein YaaU YP_003687215.1 296791 D 754252 CDS YP_003687216.1 297625453 9284483 298154..298798 1 NC_014215.1 beta-lactamase-like protein 298798 9284483 PFREUD_02470 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-lactamase-like protein YP_003687216.1 298154 D 754252 CDS YP_003687217.1 297625454 9282155 298982..299737 1 NC_014215.1 Required for anaerobic carnitine reduction. May bring reductant to caiA; electron transfer flavoprotein FixA 299737 fixA 9282155 fixA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 electron transfer flavoprotein FixA YP_003687217.1 298982 D 754252 CDS YP_003687218.1 297625455 9283559 299774..300646 1 NC_014215.1 Required for anaerobic carnitine reduction. May bring reductant to caiA; electron transfer flavoprotein FixB 300646 fixB 9283559 fixB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 electron transfer flavoprotein FixB YP_003687218.1 299774 D 754252 CDS YP_003687219.1 297625456 9283560 300649..301953 1 NC_014215.1 electron transfer flavoprotein FixC 301953 fixC 9283560 fixC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 electron transfer flavoprotein FixC YP_003687219.1 300649 D 754252 CDS YP_003687220.1 297625457 9283561 301967..302260 1 NC_014215.1 Ferredoxin-like protein fixX 302260 fixX 9283561 fixX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ferredoxin-like protein fixX YP_003687220.1 301967 D 754252 CDS YP_003687221.1 297625458 9283562 304364..306136 1 NC_014215.1 DNA or RNA helicase 306136 9283562 PFREUD_02520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA or RNA helicase YP_003687221.1 304364 D 754252 CDS YP_003687222.1 297625459 9282156 306389..307060 1 NC_014215.1 hypothetical protein 307060 9282156 PFREUD_02530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687222.1 306389 D 754252 CDS YP_003687223.1 297625460 9282157 complement(307148..308566) 1 NC_014215.1 UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + H+; UDP-glucose 6-dehydrogenase 308566 udgA 9282157 udgA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-glucose 6-dehydrogenase YP_003687223.1 307148 R 754252 CDS YP_003687224.1 297625461 9284450 308658..310292 1 NC_014215.1 ATP + L-arginine + tRNA(Arg) <=> AMP + Pyrophosphate + L-arginyl-tRNA(Arg); arginyl-tRNA synthetase 310292 argS 9284450 argS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arginyl-tRNA synthetase YP_003687224.1 308658 D 754252 CDS YP_003687225.1 297625462 9283337 complement(310470..311360) 1 NC_014215.1 FepC 311360 fepC3 9283337 fepC3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FepC YP_003687225.1 310470 R 754252 CDS YP_003687226.1 297625463 9283550 complement(311357..312322) 1 NC_014215.1 ABC transporter permease 312322 9283550 PFREUD_02570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687226.1 311357 R 754252 CDS YP_003687227.1 297625464 9282158 complement(312436..313494) 1 NC_014215.1 ABC transporter permease 313494 9282158 PFREUD_02580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687227.1 312436 R 754252 CDS YP_003687228.1 297625465 9282159 313742..314737 1 NC_014215.1 ABC transporter 314737 9282159 PFREUD_02590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687228.1 313742 D 754252 CDS YP_003687229.1 297625466 9282160 complement(314916..315701) 1 NC_014215.1 (phosphate)n + D-glucose = (phosphate)n-1 + D-glucose 6-phosphate; polyphosphate glucokinase 315701 ppgK 9282160 ppgK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polyphosphate glucokinase YP_003687229.1 314916 R 754252 CDS YP_003687230.1 297625467 9284108 complement(315813..317210) 1 NC_014215.1 Sodium:sulfate symporter transmembrane 317210 9284108 PFREUD_02610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sodium:sulfate symporter transmembrane YP_003687230.1 315813 R 754252 CDS YP_003687231.1 297625468 9282161 317523..318497 1 NC_014215.1 # UDP-glucose <=> UDP-D-galactose dTDP-glucose <=> dTDP-galactose; UDP-glucose 4-epimerase 318497 galE2 9282161 galE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-glucose 4-epimerase YP_003687231.1 317523 D 754252 CDS YP_003687232.1 297625469 9283593 complement(318544..319236) 1 NC_014215.1 TetR family transcriptional regulator 319236 tetR3 9283593 tetR3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003687232.1 318544 R 754252 CDS YP_003687233.1 297625470 9284322 319561..321960 1 NC_014215.1 D-glucoside + H2O <=> ROH + alpha-D-glucose; beta-glucosidase 321960 9284322 PFREUD_02640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-glucosidase YP_003687233.1 319561 D 754252 CDS YP_003687234.1 297625471 9282162 322362..323750 1 NC_014215.1 sugar transporter 323750 9282162 PFREUD_02650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar transporter YP_003687234.1 322362 D 754252 CDS YP_003687235.1 297625472 9282163 323743..325419 1 NC_014215.1 metallophosphoesterase 325419 9282163 PFREUD_02660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metallophosphoesterase YP_003687235.1 323743 D 754252 CDS YP_003687236.1 297625473 9282164 325426..326154 1 NC_014215.1 MgtC, Mg2+ transporter protein 326154 9282164 PFREUD_02670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MgtC, Mg2+ transporter protein YP_003687236.1 325426 D 754252 CDS YP_003687237.1 297625474 9282165 complement(326224..327531) 1 NC_014215.1 transposase 327531 tnpA 9282165 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687237.1 326224 R 754252 CDS YP_003687238.1 297625475 9284361 complement(327498..327572) 1 NC_014215.1 hypothetical protein 327572 9284361 PFREUD_02680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687238.1 327498 R 754252 CDS YP_003687239.1 297625476 9282166 complement(327613..327705) 1 NC_014215.1 hypothetical protein 327705 9282166 PFREUD_02690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687239.1 327613 R 754252 CDS YP_003687240.1 297625477 9282167 327879..329297 1 NC_014215.1 glycerol-3-phosphate transporter 329297 glpT 9282167 glpT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerol-3-phosphate transporter YP_003687240.1 327879 D 754252 CDS YP_003687241.1 297625478 9283634 complement(329587..329790) 1 NC_014215.1 hypothetical protein 329790 9283634 PFREUD_02710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687241.1 329587 R 754252 CDS YP_003687242.1 297625479 9282168 complement(329883..330326) 1 NC_014215.1 NUDIX hydrolase 330326 9282168 PFREUD_02720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003687242.1 329883 R 754252 CDS YP_003687243.1 297625480 9282169 complement(330410..330844) 1 NC_014215.1 very short patch repair endonuclease NaeI 330844 naeIV 9282169 naeIV Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 very short patch repair endonuclease NaeI YP_003687243.1 330410 R 754252 CDS YP_003687244.1 297625481 9283940 complement(330828..336464) 1 NC_014215.1 hypothetical protein 336464 9283940 PFREUD_02740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687244.1 330828 R 754252 CDS YP_003687245.1 297625482 9282170 complement(336538..337989) 1 NC_014215.1 hypothetical protein 337989 9282170 PFREUD_02750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687245.1 336538 R 754252 CDS YP_003687246.1 297625483 9282171 complement(337979..340090) 1 NC_014215.1 hypothetical protein 340090 9282171 PFREUD_02760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687246.1 337979 R 754252 CDS YP_003687247.1 297625484 9282172 complement(340087..341745) 1 NC_014215.1 S-adenosyl-L-methionine + DNA <=> S-adenosyl-L-homocysteine + DNA 5-methylcytosine and S-adenosyl-L-methionine + DNA cytosine <=> S-adenosyl-L-homocysteine + DNA 5-methylcytosine; DNA (cytosine-5-)-methyltransferase 341745 dcm 9282172 dcm Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA (cytosine-5-)-methyltransferase YP_003687247.1 340087 R 754252 CDS YP_003687248.1 297625485 9283481 complement(341894..342898) 1 NC_014215.1 carbohydrate kinase PfkB 342898 pfkB 9283481 pfkB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbohydrate kinase PfkB YP_003687248.1 341894 R 754252 CDS YP_003687249.1 297625486 9284055 complement(342895..344415) 1 NC_014215.1 cytosine/purines uracil thiamine allantoin permease 344415 codB 9284055 codB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cytosine/purines uracil thiamine allantoin permease YP_003687249.1 342895 R 754252 CDS YP_003687250.1 297625487 9283439 complement(344593..345444) 1 NC_014215.1 inositol monophosphatase 345444 impA 9283439 impA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inositol monophosphatase YP_003687250.1 344593 R 754252 CDS YP_003687251.1 297625488 9283743 complement(345437..346885) 1 NC_014215.1 Major facilitator superfamily MFS_1 346885 9283743 PFREUD_02810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Major facilitator superfamily MFS_1 YP_003687251.1 345437 R 754252 CDS YP_003687252.1 297625489 9282173 complement(347265..348419) 1 NC_014215.1 2 acetyl-CoA <=> CoA + acetoacetyl-CoA and acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA; acetyl-CoA C-acetyltransferase 348419 mmgA 9282173 mmgA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyl-CoA C-acetyltransferase YP_003687252.1 347265 R 754252 CDS YP_003687253.1 297625490 9283891 complement(348416..349474) 1 NC_014215.1 ATP + 2-Succinylbenzoate + CoA <=> AMP + Pyrophosphate + 2-Succinylbenzoyl-CoA; o-succinylbenzoate--CoA ligase 349474 menE1 9283891 menE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 o-succinylbenzoate--CoA ligase YP_003687253.1 348416 R 754252 CDS YP_003687254.1 297625491 9283867 349644..349862 1 NC_014215.1 hypothetical protein 349862 9283867 PFREUD_02840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687254.1 349644 D 754252 CDS YP_003687255.1 297625492 9282174 349917..350732 1 NC_014215.1 hypothetical protein 350732 9282174 PFREUD_02850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687255.1 349917 D 754252 CDS YP_003687256.1 297625493 9282175 350666..350941 1 NC_014215.1 hypothetical protein 350941 9282175 PFREUD_02860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687256.1 350666 D 754252 CDS YP_003687257.1 297625494 9282176 351099..351626 1 NC_014215.1 Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation.; Starvation-inducible DNA-binding protein 351626 dps 9282176 dps Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Starvation-inducible DNA-binding protein YP_003687257.1 351099 D 754252 CDS YP_003687258.1 297625495 9283522 351918..351992 1 NC_014215.1 hypothetical protein 351992 9283522 PFREUD_02880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687258.1 351918 D 754252 CDS YP_003687259.1 297625496 9282177 351959..353077 1 NC_014215.1 transposase 353077 tnpA 9282177 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687259.1 351959 D 754252 CDS YP_003687260.1 297625497 9284362 complement(353065..354138) 1 NC_014215.1 transposase 354138 tnpA 9284362 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687260.1 353065 R 754252 CDS YP_003687262.1 297625499 9282178 354264..354548 1 NC_014215.1 transposase IS3/IS911 354548 tnpA 9282178 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687262.1 354264 D 754252 CDS YP_003687263.1 297625500 9284364 354611..355414 1 NC_014215.1 integrase 355414 int 9284364 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687263.1 354611 D 754252 CDS YP_003687264.1 297625501 9283767 355411..355800 1 NC_014215.1 hypothetical protein 355800 9283767 PFREUD_02900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687264.1 355411 D 754252 CDS YP_003687265.1 297625502 9282179 complement(355871..356287) 1 NC_014215.1 hypothetical protein 356287 9282179 PFREUD_02910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687265.1 355871 R 754252 CDS YP_003687266.1 297625503 9282180 complement(356341..358491) 1 NC_014215.1 peptidoglycan binding domain-containing protein 358491 9282180 PFREUD_02920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidoglycan binding domain-containing protein YP_003687266.1 356341 R 754252 CDS YP_003687267.1 297625504 9282181 359295..360410 1 NC_014215.1 transposase 360410 tnpA 9282181 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687267.1 359295 D 754252 CDS YP_003687268.1 297625505 9284365 360502..361074 1 NC_014215.1 hypothetical protein 361074 9284365 PFREUD_02930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687268.1 360502 D 754252 CDS YP_003687269.1 297625506 9282182 361288..361425 1 NC_014215.1 hypothetical protein 361425 9282182 PFREUD_02940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687269.1 361288 D 754252 CDS YP_003687270.1 297625507 9284367 complement(363331..368112) 1 NC_014215.1 helicase 368112 9284367 PFREUD_02950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 helicase YP_003687270.1 363331 R 754252 CDS YP_003687271.1 297625508 9282184 complement(368312..368791) 1 NC_014215.1 hypothetical protein 368791 9282184 PFREUD_02960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687271.1 368312 R 754252 CDS YP_003687272.1 297625509 9282185 complement(368791..369183) 1 NC_014215.1 proteins of Bacteriophage / transcription regulator 369183 9282185 PFREUD_02970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 proteins of Bacteriophage / transcription regulator YP_003687272.1 368791 R 754252 CDS YP_003687273.1 297625510 9282186 complement(369285..369641) 1 NC_014215.1 hypothetical protein 369641 9282186 PFREUD_02980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687273.1 369285 R 754252 CDS YP_003687274.1 297625511 9282187 complement(369793..369888) 1 NC_014215.1 hypothetical protein 369888 9282187 PFREUD_02990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687274.1 369793 R 754252 CDS YP_003687275.1 297625512 9282188 complement(369885..370958) 1 NC_014215.1 over representated in Mycobacterium smegmatis; transposase 370958 tnpA 9282188 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687275.1 369885 R 754252 CDS YP_003687276.1 297625513 9284368 370998..371243 1 NC_014215.1 hypothetical protein 371243 9284368 PFREUD_03000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687276.1 370998 D 754252 CDS YP_003687277.1 297625514 9282189 371245..371397 1 NC_014215.1 hypothetical protein 371397 9282189 PFREUD_03010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687277.1 371245 D 754252 CDS YP_003687278.1 297625515 9282190 371510..372490 1 NC_014215.1 hypothetical protein 372490 9282190 PFREUD_03020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687278.1 371510 D 754252 CDS YP_003687279.1 297625516 9284369 complement(373941..374738) 1 NC_014215.1 hypothetical protein 374738 9284369 PFREUD_03030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687279.1 373941 R 754252 CDS YP_003687280.1 297625517 9282192 complement(374854..376161) 1 NC_014215.1 transposase 376161 tnpA 9282192 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687280.1 374854 R 754252 CDS YP_003687281.1 297625518 9284370 complement(376128..376202) 1 NC_014215.1 hypothetical protein 376202 9284370 PFREUD_03040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687281.1 376128 R 754252 CDS YP_003687282.1 297625519 9282194 complement(376726..377421) 1 NC_014215.1 hypothetical protein 377421 9282194 PFREUD_03060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687282.1 376726 R 754252 CDS YP_003687283.1 297625520 9282195 complement(377606..379162) 1 NC_014215.1 hypothetical protein 379162 9282195 PFREUD_03070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687283.1 377606 R 754252 CDS YP_003687284.1 297625521 9282196 379670..380323 1 NC_014215.1 Pyrophosphate + H2O <=> 2 Orthophosphate; pyrophosphatase PpaX 380323 ppaX 9282196 ppaX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyrophosphatase PpaX YP_003687284.1 379670 D 754252 CDS YP_003687285.1 297625522 9284106 380402..381451 1 NC_014215.1 3-phosphoglycerate + NAD+ <=> 3-phosphonooxypyruvate + NADH + H+ glycine, serine, threonine metabolism; phosphoglycerate dehydrogenase 381451 serA 9284106 serA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate dehydrogenase YP_003687285.1 380402 D 754252 CDS YP_003687286.1 297625523 9284276 381491..382303 1 NC_014215.1 2-Dehydro-3-deoxy-D-gluconate + NAD+ <=> (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+ and 2-deoxy-D-gluconate + NAD+ <=> 3-Dehydro-2-deoxy-D-gluconate + NADH + H+; 2-deoxy-D-gluconate 3-dehydrogenase 382303 kduD 9284276 kduD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-deoxy-D-gluconate 3-dehydrogenase YP_003687286.1 381491 D 754252 CDS YP_003687287.1 297625524 9283801 complement(382531..384054) 1 NC_014215.1 acyl-CoA + acetate = a fatty acid anion + acetyl-CoA OR: succinate + acetyl-CoA = succinyl-CoA + acetate OR (in Pf): succinate + propionyl-CoA = succinyl-CoA + propionate; coenzyme A transferase 384054 cat 9283801 cat Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 coenzyme A transferase YP_003687287.1 382531 R 754252 CDS YP_003687288.1 297625525 9283395 complement(384178..385368) 1 NC_014215.1 hypothetical protein 385368 9283395 PFREUD_03120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687288.1 384178 R 754252 CDS YP_003687289.1 297625526 9282197 385681..387021 1 NC_014215.1 hypothetical protein 387021 9282197 PFREUD_03130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687289.1 385681 D 754252 CDS YP_003687290.1 297625527 9282198 complement(387159..387776) 1 NC_014215.1 Young IG, Gibson F. Biochim. Biophys. Acta. 177 (1969) 401-11. Isochorismate + H2O <=> 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate; isochorismatase hydrolase 387776 9282198 PFREUD_03140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 isochorismatase hydrolase YP_003687290.1 387159 R 754252 CDS YP_003687291.1 297625528 9282199 complement(387889..388497) 1 NC_014215.1 hypothetical protein 388497 9282199 PFREUD_03150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687291.1 387889 R 754252 CDS YP_003687292.1 297625529 9282200 complement(388626..389480) 1 NC_014215.1 aldo/keto reductase 389480 PF2369 9282200 PF2369 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aldo/keto reductase YP_003687292.1 388626 R 754252 CDS YP_003687293.1 297625530 9284040 complement(389583..390356) 1 NC_014215.1 hypothetical protein 390356 9284040 PFREUD_03170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687293.1 389583 R 754252 CDS YP_003687294.1 297625531 9282201 complement(390563..391552) 1 NC_014215.1 S-adenosyl-L-methionine + rRNA <=> S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine; rRNA (guanine-N2-)-methyltransferase 391552 rsmC 9282201 rsmC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 rRNA (guanine-N2-)-methyltransferase YP_003687294.1 390563 R 754252 CDS YP_003687295.1 297625532 9284254 391645..392967 1 NC_014215.1 These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs.; Multi antimicrobial extrusion protein MatE 392967 matE 9284254 matE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Multi antimicrobial extrusion protein MatE YP_003687295.1 391645 D 754252 CDS YP_003687296.1 297625533 9283861 complement(393183..394094) 1 NC_014215.1 Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA.; restriction system protein 394094 mrr 9283861 mrr Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 restriction system protein YP_003687296.1 393183 R 754252 CDS YP_003687297.1 297625534 9283910 394636..395529 1 NC_014215.1 hypothetical protein 395529 9283910 PFREUD_03210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687297.1 394636 D 754252 CDS YP_003687299.1 297625536 9282203 395738..398395 1 NC_014215.1 ATP + pyruvate + Orthophosphate <=> AMP + phosphoenolpyruvate + Pyrophosphate Cofactor : Magnesium. homodimer; pyruvate phosphate dikinase 398395 ppdk 9282203 ppdk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyruvate phosphate dikinase YP_003687299.1 395738 D 754252 CDS YP_003687300.1 297625537 9284107 398895..401711 1 NC_014215.1 hypothetical protein 401711 9284107 PFREUD_03240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687300.1 398895 D 754252 CDS YP_003687301.1 297625538 9282204 401947..402939 1 NC_014215.1 hypothetical protein 402939 rbsK 9282204 rbsK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687301.1 401947 D 754252 CDS YP_003687302.1 297625539 9284160 complement(403172..405037) 1 NC_014215.1 two component system regulator; sensor protein 405037 9284160 PFREUD_03260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sensor protein YP_003687302.1 403172 R 754252 CDS YP_003687303.1 297625540 9282205 complement(405018..405746) 1 NC_014215.1 highly similar to protein Q9ADN7_STRCO from Streptomyces coelicolor; two component system response regulator 405746 9282205 PFREUD_03270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two component system response regulator YP_003687303.1 405018 R 754252 CDS YP_003687304.1 297625541 9282206 406297..407262 1 NC_014215.1 ABC transporter periplasmic protein 407262 9282206 PFREUD_03280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter periplasmic protein YP_003687304.1 406297 D 754252 CDS YP_003687305.1 297625542 9282207 407259..408524 1 NC_014215.1 methionine import ATP-binding protein metN 408524 metN 9282207 metN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionine import ATP-binding protein metN YP_003687305.1 407259 D 754252 CDS YP_003687306.1 297625543 9283882 408521..409177 1 NC_014215.1 ABC transporter permease 409177 9283882 PFREUD_03300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687306.1 408521 D 754252 CDS YP_003687307.1 297625544 9282208 complement(409301..410917) 1 NC_014215.1 S-layer protein 410917 slh1 9282208 slh1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S-layer protein YP_003687307.1 409301 R 754252 CDS YP_003687308.1 297625545 9284283 complement(410990..411565) 1 NC_014215.1 hypothetical protein 411565 9284283 PFREUD_03320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687308.1 410990 R 754252 CDS YP_003687309.1 297625546 9282209 411947..412519 1 NC_014215.1 This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.; PadR family transcriptional regulator 412519 padR 9282209 padR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PadR family transcriptional regulator YP_003687309.1 411947 D 754252 CDS YP_003687310.1 297625547 9283994 412562..414259 1 NC_014215.1 ABC transporter 414259 9283994 PFREUD_03340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687310.1 412562 D 754252 CDS YP_003687311.1 297625548 9282210 complement(414347..415663) 1 NC_014215.1 Hydroxymethylpyrimidine transporter CytX 415663 cytX 9282210 cytX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Hydroxymethylpyrimidine transporter CytX YP_003687311.1 414347 R 754252 CDS YP_003687312.1 297625549 9283470 complement(415742..416608) 1 NC_014215.1 ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate; phosphomethylpyrimidine kinase/ hydroxymethylpyrimidine phosphokinase 416608 thiD1 9283470 thiD1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphomethylpyrimidine kinase/ hydroxymethylpyrimidine phosphokinase YP_003687312.1 415742 R 754252 CDS YP_003687313.1 297625550 9284329 complement(416605..417456) 1 NC_014215.1 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphoethyl)-thiazole <=> Pyrophosphate + Thiamin monophosphate; thiamine-phosphate pyrophosphorylase 417456 thiE1 9284329 thiE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine-phosphate pyrophosphorylase YP_003687313.1 416605 R 754252 CDS YP_003687314.1 297625551 9284331 complement(417453..418313) 1 NC_014215.1 ATP + 5-(2-Hydroxyethyl)-4-methylthiazole <=> ADP + 4-methyl-5-(2-phosphoethyl)-thiazole; Hydroxyethylthiazole kinase 418313 thiM 9284331 thiM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Hydroxyethylthiazole kinase YP_003687314.1 417453 R 754252 CDS YP_003687316.1 297625553 9282211 418741..420135 1 NC_014215.1 Aromatic amino acid transport protein aroP 420135 aroP 9282211 aroP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Aromatic amino acid transport protein aroP YP_003687316.1 418741 D 754252 CDS YP_003687317.1 297625554 9283344 420252..421202 1 NC_014215.1 Cation-efflux transport protein 421202 9283344 PFREUD_03410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cation-efflux transport protein YP_003687317.1 420252 D 754252 CDS YP_003687318.1 297625555 9282212 complement(421485..421649) 1 NC_014215.1 hypothetical protein 421649 9282212 PFREUD_03420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687318.1 421485 R 754252 CDS YP_003687319.1 297625556 9282213 421683..422237 1 NC_014215.1 hypothetical protein 422237 9282213 PFREUD_03430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687319.1 421683 D 754252 CDS YP_003687320.1 297625557 9282214 complement(422300..422413) 1 NC_014215.1 hypothetical protein 422413 9282214 PFREUD_03440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687320.1 422300 R 754252 CDS YP_003687321.1 297625558 9282215 complement(422463..423446) 1 NC_014215.1 Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.; Stomatin/prohibitin 423446 hflC2 9282215 hflC2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Stomatin/prohibitin YP_003687321.1 422463 R 754252 CDS YP_003687322.1 297625559 9283699 423831..424763 1 NC_014215.1 hypothetical protein 424763 9283699 PFREUD_03460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687322.1 423831 D 754252 CDS YP_003687323.1 297625560 9282216 complement(424804..424977) 1 NC_014215.1 hypothetical protein 424977 9282216 PFREUD_03470 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687323.1 424804 R 754252 CDS YP_003687324.1 297625561 9282217 complement(425207..425452) 1 NC_014215.1 hypothetical protein 425452 9282217 PFREUD_03480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687324.1 425207 R 754252 CDS YP_003687325.1 297625562 9282218 complement(425481..426788) 1 NC_014215.1 transposase 426788 tnpA 9282218 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687325.1 425481 R 754252 CDS YP_003687326.1 297625563 9284371 complement(426755..426829) 1 NC_014215.1 hypothetical protein 426829 9284371 PFREUD_03490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687326.1 426755 R 754252 CDS YP_003687327.1 297625564 9282219 complement(426870..426956) 1 NC_014215.1 hypothetical protein 426956 9282219 PFREUD_03500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687327.1 426870 R 754252 CDS YP_003687328.1 297625565 9282220 427126..427410 1 NC_014215.1 transposase IS3/IS911 427410 tnpA 9282220 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687328.1 427126 D 754252 CDS YP_003687329.1 297625566 9284372 427473..428276 1 NC_014215.1 integrase 428276 int 9284372 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687329.1 427473 D 754252 CDS YP_003687330.1 297625567 9283768 complement(428440..428616) 1 NC_014215.1 hypothetical protein 428616 9283768 PFREUD_03510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687330.1 428440 R 754252 CDS YP_003687331.1 297625568 9282221 429006..429428 1 NC_014215.1 hypothetical protein 429428 9282221 PFREUD_03520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687331.1 429006 D 754252 CDS YP_003687332.1 297625569 9282222 429343..429615 1 NC_014215.1 hypothetical protein 429615 9282222 PFREUD_03530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687332.1 429343 D 754252 CDS YP_003687333.1 297625570 9282223 429616..429738 1 NC_014215.1 hypothetical protein 429738 9282223 PFREUD_03540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687333.1 429616 D 754252 CDS YP_003687334.1 297625571 9282224 429796..430095 1 NC_014215.1 hypothetical protein 430095 9282224 PFREUD_03550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687334.1 429796 D 754252 CDS YP_003687335.1 297625572 9282225 complement(430096..433260) 1 NC_014215.1 carboxylic ester hydrolase 433260 pf1861 9282225 pf1861 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003687335.1 430096 R 754252 CDS YP_003687336.1 297625573 9284038 complement(433496..434812) 1 NC_014215.1 anaerobic C4-dicarboxylate transporter 434812 PPA1043 9284038 PPA1043 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic C4-dicarboxylate transporter YP_003687336.1 433496 R 754252 CDS YP_003687337.1 297625574 9284097 complement(435209..435484) 1 NC_014215.1 hypothetical protein 435484 9284097 PFREUD_03580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687337.1 435209 R 754252 CDS YP_003687338.1 297625575 9282226 435942..436691 1 NC_014215.1 hypothetical protein 436691 9282226 PFREUD_03590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687338.1 435942 D 754252 CDS YP_003687339.1 297625576 9282227 436781..437023 1 NC_014215.1 hypothetical protein 437023 9282227 PFREUD_03600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687339.1 436781 D 754252 CDS YP_003687340.1 297625577 9282228 437135..438190 1 NC_014215.1 zinc-containing alcohol dehydrogenase 438190 9282228 PFREUD_03610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 zinc-containing alcohol dehydrogenase YP_003687340.1 437135 D 754252 CDS YP_003687341.1 297625578 9282229 438209..439435 1 NC_014215.1 carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. Initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. heterodimer of a small and large subunit. The small subunit promotes the hydrolysis of glutamine to ammonia, which is used by the large subunit to synthesise carbamoyl phosphate.; carbamoylphosphate synthase 439435 9282229 PFREUD_03620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbamoylphosphate synthase YP_003687341.1 438209 D 754252 CDS YP_003687342.1 297625579 9282230 439606..440121 1 NC_014215.1 hypothetical protein 440121 9282230 PFREUD_03630 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687342.1 439606 D 754252 CDS YP_003687343.1 297625580 9282231 complement(440156..440662) 1 NC_014215.1 hypothetical protein 440662 9282231 PFREUD_03640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687343.1 440156 R 754252 CDS YP_003687344.1 297625581 9282232 441518..441631 1 NC_014215.1 hypothetical protein 441631 9282232 PFREUD_03650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687344.1 441518 D 754252 CDS YP_003687345.1 297625582 9282233 441628..441822 1 NC_014215.1 hypothetical protein 441822 9282233 PFREUD_03660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687345.1 441628 D 754252 CDS YP_003687346.1 297625583 9282234 443107..443229 1 NC_014215.1 hypothetical protein 443229 9282234 PFREUD_03670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687346.1 443107 D 754252 CDS YP_003687347.1 297625584 9282235 complement(443868..444170) 1 NC_014215.1 hypothetical protein 444170 9282235 PFREUD_03680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687347.1 443868 R 754252 CDS YP_003687348.1 297625585 9282236 complement(444167..445768) 1 NC_014215.1 CRISPR-associated protein Cas1/Cas4 445768 9282236 PFREUD_03690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CRISPR-associated protein Cas1/Cas4 YP_003687348.1 444167 R 754252 CDS YP_003687349.1 297625586 9282237 complement(445758..446759) 1 NC_014215.1 hypothetical protein 446759 9282237 PFREUD_03700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687349.1 445758 R 754252 CDS YP_003687350.1 297625587 9282238 complement(446756..449371) 1 NC_014215.1 CRISPR-associated HD domain-containing protein 449371 9282238 PFREUD_03710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CRISPR-associated HD domain-containing protein YP_003687350.1 446756 R 754252 CDS YP_003687351.1 297625588 9282239 complement(449368..450909) 1 NC_014215.1 hypothetical protein 450909 9282239 PFREUD_03720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687351.1 449368 R 754252 CDS YP_003687352.1 297625589 9282240 complement(450911..452110) 1 NC_014215.1 hypothetical protein 452110 9282240 PFREUD_03730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687352.1 450911 R 754252 CDS YP_003687353.1 297625590 9282242 452643..453917 1 NC_014215.1 Threonine dehydratase 453917 9282242 PFREUD_03750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Threonine dehydratase YP_003687353.1 452643 D 754252 CDS YP_003687354.1 297625591 9282243 454391..454678 1 NC_014215.1 hemerythrin is an oligomeric protein responsible for oxygen (O2) transportation. hemerythrin was discovered in methanotrophic bacterium methylococcus capsulatus.; Hemerythrin HHE cation binding region 454678 9282243 PFREUD_03760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Hemerythrin HHE cation binding region YP_003687354.1 454391 D 754252 CDS YP_003687355.1 297625592 9282244 454684..455694 1 NC_014215.1 ArsR family transcriptional regulator 455694 9282244 PFREUD_03770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003687355.1 454684 D 754252 CDS YP_003687356.1 297625593 9282245 455769..457046 1 NC_014215.1 hypothetical protein 457046 9282245 PFREUD_03780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687356.1 455769 D 754252 CDS YP_003687357.1 297625594 9282246 457043..459679 1 NC_014215.1 transmembrane and signal peptide (TM HMM and Signal P); copper-containing nitrite reductase 459679 aniA 9282246 aniA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 copper-containing nitrite reductase YP_003687357.1 457043 D 754252 CDS YP_003687358.1 297625595 9283312 459833..461212 1 NC_014215.1 signal peptide (SignalP), transmembranaire C term (TM HMM) (carboxypeptidase ?); hypothetical protein 461212 9283312 PFREUD_03800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687358.1 459833 D 754252 CDS YP_003687359.1 297625596 9282247 461308..462024 1 NC_014215.1 Sortase, Sortase domain; transpeptidase of Gram-positive bacteria, cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond; peptidase C60, sortase A and B 462024 9282247 PFREUD_03810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase C60, sortase A and B YP_003687359.1 461308 D 754252 CDS YP_003687360.1 297625597 9282248 462094..465498 1 NC_014215.1 hypothetical protein 465498 9282248 PFREUD_03820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687360.1 462094 D 754252 CDS YP_003687361.1 297625598 9282249 465749..466057 1 NC_014215.1 hypothetical protein 466057 9282249 PFREUD_03830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687361.1 465749 D 754252 CDS YP_003687362.1 297625599 9282250 466059..466685 1 NC_014215.1 May play a role in DNA repair. It seems to be involved in an recBC-independent recombinational process of DNA repair. It may act with recF and recO; Recombination protein recR 466685 recR 9282250 recR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Recombination protein recR YP_003687362.1 466059 D 754252 CDS YP_003687363.1 297625600 9284169 complement(466711..467520) 1 NC_014215.1 hypothetical protein 467520 9284169 PFREUD_03850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687363.1 466711 R 754252 CDS YP_003687364.1 297625601 9282251 467799..471059 1 NC_014215.1 ATP + L-Isoleucine + tRNA(Ile) <=> AMP + Pyrophosphate + L-Isoleucyl-tRNA(Ile); isoleucyl-tRNA synthetase 471059 ileS 9282251 ileS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 isoleucyl-tRNA synthetase YP_003687364.1 467799 D 754252 CDS YP_003687365.1 297625602 9283737 complement(471186..472172) 1 NC_014215.1 oxidoreductase 472172 9283737 PFREUD_03870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 oxidoreductase YP_003687365.1 471186 R 754252 CDS YP_003687366.1 297625603 9282252 472341..473615 1 NC_014215.1 ATP + L-aspartate <=> ADP + 4-phospho-L-aspartate; aspartokinase 473615 ask 9282252 ask Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartokinase YP_003687366.1 472341 D 754252 CDS YP_003687367.1 297625604 9283357 473702..475645 1 NC_014215.1 hypothetical protein 475645 mviN 9283357 mviN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687367.1 473702 D 754252 CDS YP_003687368.1 297625605 9283932 475709..477772 1 NC_014215.1 ATP + L-lysine + tRNA(Lys) <=> AMP + Pyrophosphate + L-Lysyl-tRNA; lysyl-tRNA synthetase 477772 lysX 9283932 lysX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lysyl-tRNA synthetase YP_003687368.1 475709 D 754252 CDS YP_003687369.1 297625606 9283846 complement(477769..478155) 1 NC_014215.1 hypothetical protein 478155 9283846 PFREUD_03910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687369.1 477769 R 754252 CDS YP_003687370.1 297625607 9282253 complement(478309..479274) 1 NC_014215.1 ATP + D-Fructose <=> ADP + D-Fructose 6-phosphate; fructokinase 479274 frk 9282253 frk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 fructokinase YP_003687370.1 478309 R 754252 CDS YP_003687371.1 297625608 9283574 479517..480995 1 NC_014215.1 aminoacid permease 480995 9283574 PFREUD_03930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminoacid permease YP_003687371.1 479517 D 754252 CDS YP_003687372.1 297625609 9282254 complement(481091..482809) 1 NC_014215.1 hypothetical protein 482809 9282254 PFREUD_03940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687372.1 481091 R 754252 CDS YP_003687373.1 297625610 9282255 483096..483500 1 NC_014215.1 hypothetical protein 483500 9282255 PFREUD_03950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687373.1 483096 D 754252 CDS YP_003687374.1 297625611 9282256 483461..483772 1 NC_014215.1 hypothetical protein 483772 9282256 PFREUD_03960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687374.1 483461 D 754252 CDS YP_003687375.1 297625612 9282257 483836..484600 1 NC_014215.1 hypothetical protein 484600 9282257 PFREUD_03970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687375.1 483836 D 754252 CDS YP_003687376.1 297625613 9282258 484649..485365 1 NC_014215.1 hypothetical protein 485365 9282258 PFREUD_03980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687376.1 484649 D 754252 CDS YP_003687377.1 297625614 9282259 complement(485889..487457) 1 NC_014215.1 transporter 487457 9282259 PFREUD_03990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transporter YP_003687377.1 485889 R 754252 CDS YP_003687378.1 297625615 9282260 487640..488971 1 NC_014215.1 ATP + 5-phosphoribosylamine + glycine <=> ADP + Orthophosphate + 5prime-phosphoribosylglycinamide; phosphoribosylamine-glycine ligase 488971 purD 9282260 purD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylamine-glycine ligase YP_003687378.1 487640 D 754252 CDS YP_003687379.1 297625616 9284141 489000..490433 1 NC_014215.1 N6-(1,2-Dicarboxyethyl)-AMP <=> Fumarate + AMP 1-(5prime-phosphoribosyl)-5-amino-4-(N- succinocarboxamide)-imidazole These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits; adenylosuccinate lyase 490433 purB 9284141 purB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 adenylosuccinate lyase YP_003687379.1 489000 D 754252 CDS YP_003687380.1 297625617 9284139 complement(490443..491549) 1 NC_014215.1 hypothetical protein 491549 9284139 PFREUD_04020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687380.1 490443 R 754252 CDS YP_003687381.1 297625618 9282261 491647..492525 1 NC_014215.1 catalyzes the seventh step of the de novo biosynthesis of purine nucleotides, the conversion of carboximideaminoimidazole ribonucleotide (CAIR) into succinoaminoimidazolecarboximide ribonucleotide (SAICAR). CAIR and aspartic acid react in the presence of ATP and magnesium to form SAICAR.; phosphoribosylaminoimidazole-succinocarboxamide synthase 492525 purC 9282261 purC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_003687381.1 491647 D 754252 CDS YP_003687382.1 297625619 9284140 492608..492853 1 NC_014215.1 ATP + 1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate + L-aspartate <=> ADP + Orthophosphate + 1-(5-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)- imidazole; phosphoribosylformylglycinamidine synthetase 492853 purS 9284140 purS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylformylglycinamidine synthetase YP_003687382.1 492608 D 754252 CDS YP_003687383.1 297625620 9284150 492855..493532 1 NC_014215.1 ATP + 5prime-phosphoribosyl-N-formylglycinamide + L-glutamine + H2O <=> ADP + Orthophosphate + 2-(formamido)-N1-(5prime-phosphoribosyl)acetamidine + L-glutamate; phosphoribosylformylglycinamidine synthase 1 493532 purL/purQ 9284150 purL/purQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylformylglycinamidine synthase 1 YP_003687383.1 492855 D 754252 CDS YP_003687384.1 297625621 9284147 complement(493611..494309) 1 NC_014215.1 hypothetical protein 494309 9284147 PFREUD_04060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687384.1 493611 R 754252 CDS YP_003687385.1 297625622 9282262 494661..495944 1 NC_014215.1 alpha-ketoglutarate permease 495944 csbX 9282262 csbX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alpha-ketoglutarate permease YP_003687385.1 494661 D 754252 CDS YP_003687386.1 297625623 9283447 complement(496030..496965) 1 NC_014215.1 hypothetical protein 496965 9283447 PFREUD_04080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687386.1 496030 R 754252 CDS YP_003687387.1 297625624 9282263 497393..498202 1 NC_014215.1 No signal peptide (signalP) and 2 TM domains; hypothetical protein 498202 9282263 PFREUD_04090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687387.1 497393 D 754252 CDS YP_003687388.1 297625625 9282264 498591..498875 1 NC_014215.1 transposase IS3/IS911 498875 tnpA 9282264 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687388.1 498591 D 754252 CDS YP_003687389.1 297625626 9284373 498938..499741 1 NC_014215.1 integrase 499741 int 9284373 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687389.1 498938 D 754252 CDS YP_003687390.1 297625627 9283769 499738..499902 1 NC_014215.1 hypothetical protein 499902 9283769 PFREUD_04100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687390.1 499738 D 754252 CDS YP_003687391.1 297625628 9282265 complement(501875..502762) 1 NC_014215.1 phage major capsid protein, HK97 family 502762 9282265 PFREUD_04110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage major capsid protein, HK97 family YP_003687391.1 501875 R 754252 CDS YP_003687392.1 297625629 9282266 complement(502934..503635) 1 NC_014215.1 hypothetical protein 503635 9282266 PFREUD_04120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687392.1 502934 R 754252 CDS YP_003687393.1 297625630 9282267 complement(503632..503868) 1 NC_014215.1 hypothetical protein 503868 9282267 PFREUD_04130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687393.1 503632 R 754252 CDS YP_003687394.1 297625631 9282268 complement(503998..506520) 1 NC_014215.1 hypothetical protein 506520 9282268 PFREUD_04140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687394.1 503998 R 754252 CDS YP_003687395.1 297625632 9282269 complement(506517..507035) 1 NC_014215.1 hypothetical protein 507035 9282269 PFREUD_04150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687395.1 506517 R 754252 CDS YP_003687396.1 297625633 9282270 complement(507032..507196) 1 NC_014215.1 hypothetical protein 507196 9282270 PFREUD_04160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687396.1 507032 R 754252 CDS YP_003687397.1 297625634 9282271 complement(507193..507432) 1 NC_014215.1 hypothetical protein 507432 9282271 PFREUD_04170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687397.1 507193 R 754252 CDS YP_003687398.1 297625635 9282272 complement(507576..507788) 1 NC_014215.1 hypothetical protein 507788 9282272 PFREUD_04180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687398.1 507576 R 754252 CDS YP_003687399.1 297625636 9282273 complement(507831..508019) 1 NC_014215.1 hypothetical protein 508019 9282273 PFREUD_04190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687399.1 507831 R 754252 CDS YP_003687400.1 297625637 9282274 complement(508290..508664) 1 NC_014215.1 hypothetical protein 508664 9282274 PFREUD_04200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687400.1 508290 R 754252 CDS YP_003687401.1 297625638 9282275 complement(508829..509977) 1 NC_014215.1 phage integrase 509977 int 9282275 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage integrase YP_003687401.1 508829 R 754252 CDS YP_003687402.1 297625639 9282276 510349..511029 1 NC_014215.1 hypothetical protein 511029 9282276 PFREUD_04230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687402.1 510349 D 754252 CDS YP_003687403.1 297625640 9282277 complement(511551..512789) 1 NC_014215.1 carboxylic ester hydrolase 512789 pf774 9282277 pf774 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003687403.1 511551 R 754252 CDS YP_003687404.1 297625641 9284052 complement(512935..513399) 1 NC_014215.1 phosphatidylethanolamine-binding protein 513399 pepB 9284052 pepB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphatidylethanolamine-binding protein YP_003687404.1 512935 R 754252 CDS YP_003687405.1 297625642 9284025 complement(513433..515985) 1 NC_014215.1 DEAD/DEAH box helicase 515985 9284025 PFREUD_04260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DEAD/DEAH box helicase YP_003687405.1 513433 R 754252 CDS YP_003687406.1 297625643 9282278 516122..516820 1 NC_014215.1 2-dehydro-3-deoxyphosphogluconate aldolase 516820 eda 9282278 eda Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-dehydro-3-deoxyphosphogluconate aldolase YP_003687406.1 516122 D 754252 CDS YP_003687407.1 297625644 9283531 517046..518050 1 NC_014215.1 hypothetical protein 518050 9283531 PFREUD_04280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687407.1 517046 D 754252 CDS YP_003687408.1 297625645 9282279 518242..519924 1 NC_014215.1 reversible isomerization of glucose-6-phosphate : D-glucose 6-phosphate = D-fructose 6-phosphate; glucose-6-phosphate isomerase 519924 pgi 9282279 pgi Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glucose-6-phosphate isomerase YP_003687408.1 518242 D 754252 CDS YP_003687409.1 297625646 9284058 519928..520713 1 NC_014215.1 hypothetical protein 520713 9284058 PFREUD_04300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687409.1 519928 D 754252 CDS YP_003687410.1 297625647 9282280 520713..521933 1 NC_014215.1 beta-lactamase 521933 9282280 PFREUD_04310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-lactamase YP_003687410.1 520713 D 754252 CDS YP_003687411.1 297625648 9282281 522315..525101 1 NC_014215.1 FAD-linked oxidase 525101 Arth_4141 9282281 Arth_4141 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FAD-linked oxidase YP_003687411.1 522315 D 754252 CDS YP_003687412.1 297625649 9283355 complement(525260..526408) 1 NC_014215.1 acyl-CoA dehydrogenase 526408 fad 9283355 fad Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acyl-CoA dehydrogenase YP_003687412.1 525260 R 754252 CDS YP_003687413.1 297625650 9283542 526794..528125 1 NC_014215.1 recombinant protein active on 1- naphthyl propionate, extracellular (see dherbecourt 2010, AEM); carboxylic ester hydrolase 528125 pf279 9283542 pf279 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003687413.1 526794 D 754252 CDS YP_003687414.1 297625651 9284044 528122..528622 1 NC_014215.1 hypothetical protein 528622 9284044 PFREUD_04350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687414.1 528122 D 754252 CDS YP_003687415.1 297625652 9282282 complement(528647..531811) 1 NC_014215.1 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3prime->5prime double strand exonuclease that can open hairpins. It also has a 5prim single-strand endonuclease activity; ATP-dependent dsDNA exonuclease SbcC 531811 sbcC 9282282 sbcC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent dsDNA exonuclease SbcC YP_003687415.1 528647 R 754252 CDS YP_003687416.1 297625653 9284260 complement(531811..533061) 1 NC_014215.1 SbcD, DNA repair exonuclease 533061 sbcD 9284260 sbcD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 SbcD, DNA repair exonuclease YP_003687416.1 531811 R 754252 CDS YP_003687417.1 297625654 9284261 complement(533042..534259) 1 NC_014215.1 adenosine + H2O <=> inosine + NH3 and deoxyadenosine + H2O <=> deoxyinosine + NH3 and Cyclic amidines + H2O <=> Cyclic amide + NH3; adenosine deaminase 534259 add 9284261 add Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 adenosine deaminase YP_003687417.1 533042 R 754252 CDS YP_003687418.1 297625655 9283298 534442..536241 1 NC_014215.1 hypothetical protein 536241 9283298 PFREUD_04390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687418.1 534442 D 754252 CDS YP_003687419.1 297625656 9282283 536479..536850 1 NC_014215.1 hypothetical protein 536850 9282283 PFREUD_04400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687419.1 536479 D 754252 CDS YP_003687420.1 297625657 9282284 complement(536865..537419) 1 NC_014215.1 hypothetical protein 537419 9282284 PFREUD_04410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687420.1 536865 R 754252 CDS YP_003687421.1 297625658 9282285 complement(537773..538261) 1 NC_014215.1 hypothetical protein 538261 9282285 PFREUD_04420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687421.1 537773 R 754252 CDS YP_003687422.1 297625659 9282286 complement(538598..540355) 1 NC_014215.1 thiamine pyrophosphate enzyme 540355 9282286 PFREUD_04430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine pyrophosphate enzyme YP_003687422.1 538598 R 754252 CDS YP_003687423.1 297625660 9282287 complement(540495..542351) 1 NC_014215.1 monovalent cation/proton antiporter 542351 nfa14140 9282287 nfa14140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 monovalent cation/proton antiporter YP_003687423.1 540495 R 754252 CDS YP_003687424.1 297625661 9283946 542470..542730 1 NC_014215.1 hypothetical protein 542730 9283946 PFREUD_04450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687424.1 542470 D 754252 CDS YP_003687425.1 297625662 9282288 542672..542845 1 NC_014215.1 hypothetical protein 542845 9282288 PFREUD_04460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687425.1 542672 D 754252 CDS YP_003687426.1 297625663 9282289 complement(542998..543447) 1 NC_014215.1 MarR family transcriptional regulator 543447 marR1 9282289 marR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MarR family transcriptional regulator YP_003687426.1 542998 R 754252 CDS YP_003687427.1 297625664 9283858 543843..544589 1 NC_014215.1 hypothetical protein 544589 9283858 PFREUD_04480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687427.1 543843 D 754252 CDS YP_003687428.1 297625665 9282290 544801..546072 1 NC_014215.1 low-affinity phosphate transport protein 546072 PPA2042 9282290 PPA2042 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 low-affinity phosphate transport protein YP_003687428.1 544801 D 754252 CDS YP_003687429.1 297625666 9284104 546069..546299 1 NC_014215.1 hypothetical protein 546299 9284104 PFREUD_04500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687429.1 546069 D 754252 CDS YP_003687430.1 297625667 9282291 546537..547148 1 NC_014215.1 Reduced riboflavin + NADP+ <=> riboflavin + NADPH + H+; NADH-flavin reductase 547148 9282291 PFREUD_04510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH-flavin reductase YP_003687430.1 546537 D 754252 CDS YP_003687431.1 297625668 9282292 547154..547765 1 NC_014215.1 NADH-flavin reductase 547765 9282292 PFREUD_04520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH-flavin reductase YP_003687431.1 547154 D 754252 CDS YP_003687432.1 297625669 9282293 complement(547818..549677) 1 NC_014215.1 hypothetical protein 549677 9282293 PFREUD_04530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687432.1 547818 R 754252 CDS YP_003687433.1 297625670 9282294 complement(549768..552359) 1 NC_014215.1 ATP-dependent helicase HrpA 552359 hrpA1 9282294 hrpA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent helicase HrpA YP_003687433.1 549768 R 754252 CDS YP_003687434.1 297625671 9283717 complement(552428..553201) 1 NC_014215.1 * 2 S-adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-adenosyl-L-homocysteine + Precorrin 2; CobA Uroporphyrinogen III methyltransferase 553201 cobA 9283717 cobA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CobA Uroporphyrinogen III methyltransferase YP_003687434.1 552428 R 754252 CDS YP_003687435.1 297625672 9283432 complement(553198..554091) 1 NC_014215.1 Part of the ABC transporter complex cbiONQ involved in cobalt import. Responsible for energy coupling to the transport system - The complex is composed of two ATP-binding proteins (cbiO), fused or not, two transmembrane proteins (cbiQ) and a solute-binding protein (cbiN); cobalt ABC transporter ATP-binding protein 554091 cbiO1 9283432 cbiO1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt ABC transporter ATP-binding protein YP_003687435.1 553198 R 754252 CDS YP_003687436.1 297625673 9283405 complement(554088..554882) 1 NC_014215.1 cobalt transport protein CbiQ 554882 cbiQ2 9283405 cbiQ2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt transport protein CbiQ YP_003687436.1 554088 R 754252 CDS YP_003687437.1 297625674 9283410 complement(554886..555386) 1 NC_014215.1 CbiN is part of the active cobalt transport system involved in uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12); cobalt transport protein CbiN 555386 cbiN 9283410 cbiN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt transport protein CbiN YP_003687437.1 554886 R 754252 CDS YP_003687438.1 297625675 9283404 complement(555379..556086) 1 NC_014215.1 cobalt transport protein CbiM 556086 cbiM 9283404 cbiM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt transport protein CbiM YP_003687438.1 555379 R 754252 CDS YP_003687439.1 297625676 9283403 complement(556396..557160) 1 NC_014215.1 transcriptional regulator 557160 gntR 9283403 gntR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687439.1 556396 R 754252 CDS YP_003687440.1 297625677 9283652 557509..558852 1 NC_014215.1 SignalP : Signal peptide probability: 0.976 Max cleavage site probability: 0.772 between pos. 39 and 40; gluconate permease 558852 gnuT 9283652 gnuT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 gluconate permease YP_003687440.1 557509 D 754252 CDS YP_003687441.1 297625678 9283653 559009..559869 1 NC_014215.1 6-phospho-D-gluconate + NADP+ <=> D-Ribulose 5-phosphate + CO2 + NADPH + H+; 6-phosphogluconate dehydrogenase 559869 gnd1 9283653 gnd1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 6-phosphogluconate dehydrogenase YP_003687441.1 559009 D 754252 CDS YP_003687442.1 297625679 9283647 560277..562151 1 NC_014215.1 Belongs to the heat shock protein 70 family. Acts as a chaperone. Several 70 to 75 kda Hsp70 chaperones are expressed as disctinct heat shock proteins; molecular chaperone DnaK 562151 dnaK2 9283647 dnaK2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone DnaK YP_003687442.1 560277 D 754252 CDS YP_003687443.1 297625680 9283517 562316..562966 1 NC_014215.1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK; molecular chaperone DnaK 562966 grpE2 9283517 grpE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone DnaK YP_003687443.1 562316 D 754252 CDS YP_003687444.1 297625681 9283665 563028..564200 1 NC_014215.1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins; molecular chaperone DnaJ 564200 dnaJ2 9283665 dnaJ2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone DnaJ YP_003687444.1 563028 D 754252 CDS YP_003687445.1 297625682 9283514 564293..564727 1 NC_014215.1 Binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon; heat shock protein transcriptional repressor HspR2 564727 hspr2 9283514 hspr2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 heat shock protein transcriptional repressor HspR2 YP_003687445.1 564293 D 754252 CDS YP_003687446.1 297625683 9283728 complement(564886..565842) 1 NC_014215.1 ATP + N-acetyl-D-glucosamine <=> ADP + N-acetyl-D-glucosamine 6-phosphate; BadF/BadG/BcrA/BcrD ATPase family protein 565842 9283728 PFREUD_04670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 BadF/BadG/BcrA/BcrD ATPase family protein YP_003687446.1 564886 R 754252 CDS YP_003687447.1 297625684 9282295 566142..568406 1 NC_014215.1 ATP + 5 prime-phosphoribosyl-N-formylglycinamide + L-glutamine + H2O <=> ADP + Orthophosphate + 2-(formamido)-N1-(5 prime-phosphoribosyl)acetamidine + L-glutamate; phosphoribosylformylglycinamidine synthase II 568406 purL 9282295 purL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylformylglycinamidine synthase II YP_003687447.1 566142 D 754252 CDS YP_003687448.1 297625685 9284146 568411..569757 1 NC_014215.1 Zinc metallopeptidase 569757 9284146 PFREUD_04690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Zinc metallopeptidase YP_003687448.1 568411 D 754252 CDS YP_003687449.1 297625686 9282296 569757..570233 1 NC_014215.1 hypothetical protein 570233 9282296 PFREUD_04700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687449.1 569757 D 754252 CDS YP_003687450.1 297625687 9282297 570133..570339 1 NC_014215.1 hypothetical protein 570339 9282297 PFREUD_04710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687450.1 570133 D 754252 CDS YP_003687451.1 297625688 9282298 570364..572040 1 NC_014215.1 ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate; formate--tetrahydrofolate ligase 572040 fhs 9282298 fhs Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 formate--tetrahydrofolate ligase YP_003687451.1 570364 D 754252 CDS YP_003687452.1 297625689 9283555 complement(572142..572768) 1 NC_014215.1 Kinase 572768 9283555 PFREUD_04730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Kinase YP_003687452.1 572142 R 754252 CDS YP_003687453.1 297625690 9282299 complement(572770..574119) 1 NC_014215.1 hypothetical protein 574119 9282299 PFREUD_04740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687453.1 572770 R 754252 CDS YP_003687454.1 297625691 9282300 complement(574123..574392) 1 NC_014215.1 hypothetical protein 574392 9282300 PFREUD_04750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687454.1 574123 R 754252 CDS YP_003687455.1 297625692 9282301 574662..575501 1 NC_014215.1 hypothetical protein 575501 9282301 PFREUD_04760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687455.1 574662 D 754252 CDS YP_003687456.1 297625693 9282302 575602..577143 1 NC_014215.1 5-phosphoribosylamine + Pyrophosphate + L-glutamate <=> L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O; amidophosphoribosyltransferase 577143 purF 9282302 purF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amidophosphoribosyltransferase YP_003687456.1 575602 D 754252 CDS YP_003687457.1 297625694 9284143 577140..578201 1 NC_014215.1 phosphoribosylformylglycinamidine cyclo-ligase 578201 purM 9284143 purM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylformylglycinamidine cyclo-ligase YP_003687457.1 577140 D 754252 CDS YP_003687458.1 297625695 9284148 complement(578289..578357) 1 NC_014215.1 hypothetical protein 578357 9284148 PFREUD_04790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687458.1 578289 R 754252 CDS YP_003687459.1 297625696 9282303 578435..578665 1 NC_014215.1 hypothetical protein 578665 9282303 PFREUD_04800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687459.1 578435 D 754252 CDS YP_003687460.1 297625697 9282304 578917..579999 1 NC_014215.1 recombinant protein active on 1- naphthyl actetate and 1- naphthyl propionate; carboxylic ester hydrolase 579999 pf962 9282304 pf962 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003687460.1 578917 D 754252 CDS YP_003687461.1 297625698 9282307 complement(580722..582440) 1 NC_014215.1 cell-wall peptidases, NlpC/P60 family secreted protein 582440 9282307 PFREUD_04850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell-wall peptidases, NlpC/P60 family secreted protein YP_003687461.1 580722 R 754252 CDS YP_003687462.1 297625699 9282308 complement(582880..583686) 1 NC_014215.1 ABC transporter permease 583686 9282308 PFREUD_04860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687462.1 582880 R 754252 CDS YP_003687463.1 297625700 9283954 complement(584354..584722) 1 NC_014215.1 ABC transporter 584722 9283954 PFREUD_04880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687463.1 584354 R 754252 CDS YP_003687464.1 297625701 9282310 584891..585658 1 NC_014215.1 TetR family transcriptional regulator 585658 tetR4 9282310 tetR4 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003687464.1 584891 D 754252 CDS YP_003687465.1 297625702 9282311 complement(586152..587357) 1 NC_014215.1 transposase for IS3514b 587357 9282311 PFREUD_24640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase for IS3514b YP_003687465.1 586152 R 754252 CDS YP_003687466.1 297625703 9283279 587567..587992 1 NC_014215.1 ArsR family transcriptional regulator 587992 arsR2 9283279 arsR2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003687466.1 587567 D 754252 CDS YP_003687467.1 297625704 9283349 587989..589860 1 NC_014215.1 SignalP : Signal anchor transmembrane according to TM HMM; ATPase P 589860 9283349 PFREUD_04920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase P YP_003687467.1 587989 D 754252 CDS YP_003687468.1 297625705 9282312 complement(589997..591163) 1 NC_014215.1 L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate; aspartate/tyrosine/aromatic aminotransferase 591163 aspB 9282312 aspB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate/tyrosine/aromatic aminotransferase YP_003687468.1 589997 R 754252 CDS YP_003687469.1 297625706 9283362 complement(591226..592191) 1 NC_014215.1 (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+; 2-dehydropantoate 2-reductase 592191 ApbA 9283362 ApbA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-dehydropantoate 2-reductase YP_003687469.1 591226 R 754252 CDS YP_003687470.1 297625707 9283314 complement(592188..593213) 1 NC_014215.1 zinc-containing alcohol dehydrogenase 593213 KradDRAFT_4229 9283314 KradDRAFT_4229 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 zinc-containing alcohol dehydrogenase YP_003687470.1 592188 R 754252 CDS YP_003687471.1 297625708 9283802 complement(593531..593875) 1 NC_014215.1 hypothetical protein 593875 9283802 PFREUD_04960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687471.1 593531 R 754252 CDS YP_003687472.1 297625709 9282313 complement(594428..595510) 1 NC_014215.1 Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.; transaldolase 595510 tal1 9282313 tal1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transaldolase YP_003687472.1 594428 R 754252 CDS YP_003687473.1 297625710 9284313 complement(595709..596308) 1 NC_014215.1 hypothetical protein 596308 9284313 PFREUD_04980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687473.1 595709 R 754252 CDS YP_003687474.1 297625711 9282314 complement(596489..596836) 1 NC_014215.1 PRC-barrel protein 596836 9282314 PFREUD_04990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PRC-barrel protein YP_003687474.1 596489 R 754252 CDS YP_003687475.1 297625712 9282315 complement(596958..597719) 1 NC_014215.1 hypothetical protein 597719 pf1420 9282315 pf1420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687475.1 596958 R 754252 CDS YP_003687476.1 297625713 9284031 complement(597716..598528) 1 NC_014215.1 hypothetical protein 598528 pf2416 9284031 pf2416 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687476.1 597716 R 754252 CDS YP_003687477.1 297625714 9284041 598718..599686 1 NC_014215.1 Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.; Co/Zn/Cd cation transporter CzcD 599686 czcD 9284041 czcD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Co/Zn/Cd cation transporter CzcD YP_003687477.1 598718 D 754252 CDS YP_003687478.1 297625715 9283471 599715..600179 1 NC_014215.1 dCMP + H2O <=> dUMP + NH3 deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP; deoxycytidylate deaminase 600179 9283471 PFREUD_05030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 deoxycytidylate deaminase YP_003687478.1 599715 D 754252 CDS YP_003687479.1 297625716 9282316 complement(600205..600603) 1 NC_014215.1 PRC-barrel protein 600603 9282316 PFREUD_05040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PRC-barrel protein YP_003687479.1 600205 R 754252 CDS YP_003687480.1 297625717 9282317 complement(600766..601194) 1 NC_014215.1 membrane efflux protein MFS 601194 9282317 PFREUD_05050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 membrane efflux protein MFS YP_003687480.1 600766 R 754252 CDS YP_003687481.1 297625718 9282318 complement(601228..602043) 1 NC_014215.1 membrane efflux protein MFS 602043 9282318 PFREUD_05060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 membrane efflux protein MFS YP_003687481.1 601228 R 754252 CDS YP_003687482.1 297625719 9282319 complement(602377..602631) 1 NC_014215.1 hypothetical protein 602631 9282319 PFREUD_05070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687482.1 602377 R 754252 CDS YP_003687483.1 297625720 9282320 602812..603693 1 NC_014215.1 Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side subunit to DHNA. The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2), the attachment of the isoprenoid side subunit, and a quinol-to-quinone oxidation, which is thought to be spontaneous; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 603693 menA 9282320 menA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_003687483.1 602812 D 754252 CDS YP_003687484.1 297625721 9283863 complement(603710..605479) 1 NC_014215.1 nuclease RecB 605479 9283863 PFREUD_05090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nuclease RecB YP_003687484.1 603710 R 754252 CDS YP_003687485.1 297625722 9282321 complement(605606..606301) 1 NC_014215.1 methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) / S-adenosyl-L-methionine + demethylmenaquinol = s-adenosyl-L-homocysteine + menaquinol / Cofactor biosynthesis; menaquinone biosynthesis; menaquinone from chorismate: step 7/7.; menaquinone biosynthesis methyltransferase 606301 ubiE 9282321 ubiE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 menaquinone biosynthesis methyltransferase YP_003687485.1 605606 R 754252 CDS YP_003687486.1 297625723 9284448 606498..607181 1 NC_014215.1 ABC transporter ATP-binding protein 607181 9284448 PFREUD_05110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687486.1 606498 D 754252 CDS YP_003687487.1 297625724 9282322 607178..608983 1 NC_014215.1 hypothetical protein 608983 9282322 PFREUD_05120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687487.1 607178 D 754252 CDS YP_003687488.1 297625725 9282323 complement(609029..610267) 1 NC_014215.1 Chorismate <=> Isochorismate; menaquinone-specific isochorismate synthase 610267 dhbC 9282323 dhbC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 menaquinone-specific isochorismate synthase YP_003687488.1 609029 R 754252 CDS YP_003687489.1 297625726 9283497 610613..611944 1 NC_014215.1 electron transfer oxidoreductase 611944 9283497 PFREUD_05140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 electron transfer oxidoreductase YP_003687489.1 610613 D 754252 CDS YP_003687491.1 297625728 9282325 612001..612366 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH-quinone oxidoreductase 612366 nuoA 9282325 nuoA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH-quinone oxidoreductase YP_003687491.1 612001 D 754252 CDS YP_003687492.1 297625729 9283963 612385..612942 1 NC_014215.1 # Ubiquinol + NAD+ <=> Ubiquinone + NADH + H+; NADH dehydrogenase I subunit B 612942 nuoB 9283963 nuoB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit B YP_003687492.1 612385 D 754252 CDS YP_003687493.1 297625730 9283964 612939..613706 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit C 613706 nuoC 9283964 nuoC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit C YP_003687493.1 612939 D 754252 CDS YP_003687494.1 297625731 9283965 613703..615076 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit D 615076 nuoD 9283965 nuoD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit D YP_003687494.1 613703 D 754252 CDS YP_003687495.1 297625732 9283966 615132..615863 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH-quinone oxidoreductase subunit E 615863 nuoE 9283966 nuoE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH-quinone oxidoreductase subunit E YP_003687495.1 615132 D 754252 CDS YP_003687496.1 297625733 9283967 615860..617200 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit F 617200 nuoF 9283967 nuoF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit F YP_003687496.1 615860 D 754252 CDS YP_003687497.1 297625734 9283968 617197..619608 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit G 619608 nuoG 9283968 nuoG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit G YP_003687497.1 617197 D 754252 CDS YP_003687498.1 297625735 9283969 619605..620975 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit H 620975 nuoH 9283969 nuoH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit H YP_003687498.1 619605 D 754252 CDS YP_003687499.1 297625736 9283970 620976..621548 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit I 621548 nuoI 9283970 nuoI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit I YP_003687499.1 620976 D 754252 CDS YP_003687500.1 297625737 9283971 621545..622414 1 NC_014215.1 Ubiquinol + NAD+ <=> Ubiquinone + NADH + H+ / Ubiquinol <=> Ubiquinone + 2 H+; NADH dehydrogenase I subunit J 622414 nuoJ 9283971 nuoJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit J YP_003687500.1 621545 D 754252 CDS YP_003687501.1 297625738 9283972 622411..622710 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase I subunit K 622710 nuoK 9283972 nuoK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit K YP_003687501.1 622411 D 754252 CDS YP_003687502.1 297625739 9283973 622721..624628 1 NC_014215.1 Acceptor + NADH + H+ <=> Reduced acceptor + NAD+; NADH dehydrogenase (quinone) 624628 nuoL 9283973 nuoL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase (quinone) YP_003687502.1 622721 D 754252 CDS YP_003687503.1 297625740 9283974 624643..626184 1 NC_014215.1 Ubiquinol + NAD+ <=> Ubiquinone + NADH + H+; NADH dehydrogenase I subunit M 626184 nuoM 9283974 nuoM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit M YP_003687503.1 624643 D 754252 CDS YP_003687504.1 297625741 9283975 626188..627744 1 NC_014215.1 Ubiquinol + NAD+ <=> Ubiquinone + NADH + H+ / Ubiquinol <=> Ubiquinone + 2 H+; NADH dehydrogenase I subunit N 627744 nuoN 9283975 nuoN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase I subunit N YP_003687504.1 626188 D 754252 CDS YP_003687505.1 297625742 9283976 627665..628735 1 NC_014215.1 all-trans-Hexaprenyl diphosphate + Isopentenyl diphosphate <=> all-trans-Heptaprenyl diphosphate + Pyrophosphate; Heptaprenyl diphosphate synthase component II 628735 idsA 9283976 idsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Heptaprenyl diphosphate synthase component II YP_003687505.1 627665 D 754252 CDS YP_003687506.1 297625743 9283736 complement(628865..629320) 1 NC_014215.1 hypothetical protein 629320 9283736 PFREUD_05310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687506.1 628865 R 754252 CDS YP_003687507.1 297625744 9282326 complement(629393..630598) 1 NC_014215.1 hypothetical protein 630598 9282326 PFREUD_05320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687507.1 629393 R 754252 CDS YP_003687508.1 297625745 9282327 complement(630686..632641) 1 NC_014215.1 In bacteria they may be used for digestion of milk. believed to be involved with milk protein cleavage.; peptidase M13 632641 9282327 PFREUD_05330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase M13 YP_003687508.1 630686 R 754252 CDS YP_003687509.1 297625746 9282328 complement(632789..633868) 1 NC_014215.1 thiamine pyrophosphate 633868 9282328 PFREUD_05340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine pyrophosphate YP_003687509.1 632789 R 754252 CDS YP_003687510.1 297625747 9282329 complement(633865..635754) 1 NC_014215.1 pyruvate flavodoxin/ferredoxin oxidoreductase 635754 9282329 PFREUD_05350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyruvate flavodoxin/ferredoxin oxidoreductase YP_003687510.1 633865 R 754252 CDS YP_003687511.1 297625748 9282330 635926..637515 1 NC_014215.1 hypothetical protein 637515 9282330 PFREUD_05360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687511.1 635926 D 754252 CDS YP_003687512.1 297625749 9282331 637682..638068 1 NC_014215.1 hypothetical protein 638068 9282331 PFREUD_05370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687512.1 637682 D 754252 CDS YP_003687513.1 297625750 9282332 complement(638127..639068) 1 NC_014215.1 Exonucleolytic cleavage in the 3 prime- to 5 prime -direction to yield nucleoside 5 prime-phosphates; exodeoxyribonuclease III/exonuclease III 639068 xthA 9282332 xthA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exodeoxyribonuclease III/exonuclease III YP_003687513.1 638127 R 754252 CDS YP_003687514.1 297625751 9284481 639168..639641 1 NC_014215.1 hypothetical protein 639641 9284481 PFREUD_05390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687514.1 639168 D 754252 CDS YP_003687515.1 297625752 9282334 640165..640728 1 NC_014215.1 2 RSH + ROOH <=> R-S-S-R + H2O + ROH; Peroxiredoxin/Alkyl hydroperoxide reductase subunit C 640728 ahpC 9282334 ahpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Peroxiredoxin/Alkyl hydroperoxide reductase subunit C YP_003687515.1 640165 D 754252 CDS YP_003687516.1 297625753 9283303 640907..642607 1 NC_014215.1 alkyl hydroperoxide reductase 642607 ahpF 9283303 ahpF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alkyl hydroperoxide reductase YP_003687516.1 640907 D 754252 CDS YP_003687517.1 297625754 9282336 643006..643176 1 NC_014215.1 50S ribosomal protein L33 643176 rpmG 9282336 rpmG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L33 YP_003687517.1 643006 D 754252 CDS YP_003687518.1 297625755 9284227 643324..643758 1 NC_014215.1 hypothetical protein 643758 9284227 PFREUD_05460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687518.1 643324 D 754252 CDS YP_003687519.1 297625756 9282337 643755..644186 1 NC_014215.1 Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel beta-sheet wrapped around a central alpha helix, referred to as a hot dog fold. The active site lies within a substrate-binding tunnel formed by the homodimer; hypothetical protein 644186 9282337 PFREUD_05470 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687519.1 643755 D 754252 CDS YP_003687520.1 297625757 9282338 644256..645389 1 NC_014215.1 UDP-N-acetylenolpyruvoylglucosamine reductase 645389 murB 9282338 murB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylenolpyruvoylglucosamine reductase YP_003687520.1 644256 D 754252 CDS YP_003687521.1 297625758 9283917 645411..646895 1 NC_014215.1 hypothetical protein 646895 9283917 PFREUD_05490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687521.1 645411 D 754252 CDS YP_003687522.1 297625759 9282340 647328..647915 1 NC_014215.1 SecE/Sec61-gamma subunit of protein translocation complex 647915 secE 9282340 secE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 SecE/Sec61-gamma subunit of protein translocation complex YP_003687522.1 647328 D 754252 CDS YP_003687523.1 297625760 9284272 647935..648822 1 NC_014215.1 transcription antitermination protein NusG 648822 nusG 9284272 nusG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription antitermination protein NusG YP_003687523.1 647935 D 754252 CDS YP_003687524.1 297625761 9283979 648932..649360 1 NC_014215.1 50S ribosomal protein L11 649360 rplK 9283979 rplK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L11 YP_003687524.1 648932 D 754252 CDS YP_003687525.1 297625762 9284207 649482..650192 1 NC_014215.1 50S ribosomal protein L1 650192 rplA 9284207 rplA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L1 YP_003687525.1 649482 D 754252 CDS YP_003687526.1 297625763 9284199 650368..651231 1 NC_014215.1 Catalyzes the transfer of the endogenously synthesized lipoate to apoproteins, creating an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoate-dependent enzymes. Utilizes lipoyl-acyl-carrier-protein as a source of lipoyl groups.; lipoyltransferase 651231 lipB 9284199 lipB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lipoyltransferase YP_003687526.1 650368 D 754252 CDS YP_003687527.1 297625764 9283828 651228..652178 1 NC_014215.1 Octanoyl-ACP + 2 sulfurs = lipoyl-ACP. Catalyzes the radical-mediated insertion of two sulfur atoms into an octanoyl group bound to acyl-carrier-protein (ACP) to produce a lipoyl group; lipoic acid synthetase 652178 lipA 9283828 lipA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lipoic acid synthetase YP_003687527.1 651228 D 754252 CDS YP_003687528.1 297625765 9283827 complement(652368..653255) 1 NC_014215.1 transposase 653255 tnpB 9283827 tnpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003687528.1 652368 R 754252 CDS YP_003687529.1 297625766 9284397 complement(653288..653632) 1 NC_014215.1 transposase IS3/IS911 653632 TnpD 9284397 TnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003687529.1 653288 R 754252 CDS YP_003687530.1 297625767 9284408 653935..654582 1 NC_014215.1 50S ribosomal protein L10 654582 rplJ 9284408 rplJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L10 YP_003687530.1 653935 D 754252 CDS YP_003687531.1 297625768 9284206 654599..654994 1 NC_014215.1 50S ribosomal protein L7/L12 654994 rplL 9284206 rplL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L7/L12 YP_003687531.1 654599 D 754252 CDS YP_003687532.1 297625769 9284208 655241..655891 1 NC_014215.1 hypothetical protein 655891 9284208 PFREUD_05590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687532.1 655241 D 754252 CDS YP_003687533.1 297625770 9282341 656217..659693 1 NC_014215.1 DNA-directed RNA polymerase subunit beta 659693 rpoB 9282341 rpoB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA-directed RNA polymerase subunit beta YP_003687533.1 656217 D 754252 CDS YP_003687534.1 297625771 9284230 659795..663685 1 NC_014215.1 RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase; DNA-directed RNA polymerase subunit beta 663685 rpoC 9284230 rpoC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA-directed RNA polymerase subunit beta YP_003687534.1 659795 D 754252 CDS YP_003687535.1 297625772 9284231 664145..664516 1 NC_014215.1 30S ribosomal protein S12 664516 rpsL 9284231 rpsL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S12 YP_003687535.1 664145 D 754252 CDS YP_003687536.1 297625773 9284245 664516..664986 1 NC_014215.1 30S ribosomal protein S7 664986 rpsG 9284245 rpsG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S7 YP_003687536.1 664516 D 754252 CDS YP_003687537.1 297625774 9284241 665157..667256 1 NC_014215.1 elongation factor G 667256 fusA 9284241 fusA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 elongation factor G YP_003687537.1 665157 D 754252 CDS YP_003687538.1 297625775 9283588 667491..668681 1 NC_014215.1 elongation factor Tu 668681 tuf 9283588 tuf Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 elongation factor Tu YP_003687538.1 667491 D 754252 CDS YP_003687539.1 297625776 9284443 complement(668875..670353) 1 NC_014215.1 hypothetical protein 670353 9284443 PFREUD_05660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687539.1 668875 R 754252 CDS YP_003687540.1 297625777 9282342 670434..671036 1 NC_014215.1 hypothetical protein 671036 9282342 PFREUD_05670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687540.1 670434 D 754252 CDS YP_003687541.1 297625778 9282343 671193..672656 1 NC_014215.1 glutamyl-tRNA synthetase 672656 gltX 9282343 gltX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamyl-tRNA synthetase YP_003687541.1 671193 D 754252 CDS YP_003687542.1 297625779 9283639 complement(672653..673648) 1 NC_014215.1 integrase core domain. integrase mediates integration of a DNA copy of the viral genome into the host chromosome.; integrase 673648 int 9283639 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687542.1 672653 R 754252 CDS YP_003687543.1 297625780 9283770 673798..674670 1 NC_014215.1 branched-chain amino acid aminotransferase 674670 pabC 9283770 pabC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 branched-chain amino acid aminotransferase YP_003687543.1 673798 D 754252 CDS YP_003687544.1 297625781 9283993 675105..675416 1 NC_014215.1 30S ribosomal protein S10 675416 rpsJ 9283993 rpsJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S10 YP_003687544.1 675105 D 754252 CDS YP_003687545.1 297625782 9284243 675413..676087 1 NC_014215.1 50S ribosomal protein L3 676087 rplC 9284243 rplC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L3 YP_003687545.1 675413 D 754252 CDS YP_003687546.1 297625783 9284201 676084..676785 1 NC_014215.1 50S ribosomal protein L4 676785 rplD 9284201 rplD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L4 YP_003687546.1 676084 D 754252 CDS YP_003687547.1 297625784 9284202 676782..677093 1 NC_014215.1 50S ribosomal protein L23 677093 rplW 9284202 rplW Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L23 YP_003687547.1 676782 D 754252 CDS YP_003687548.1 297625785 9284219 677132..677968 1 NC_014215.1 50S ribosomal protein L2 677968 rplB 9284219 rplB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L2 YP_003687548.1 677132 D 754252 CDS YP_003687549.1 297625786 9284200 677986..678267 1 NC_014215.1 30S ribosomal protein S19 678267 rpsS 9284200 rpsS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S19 YP_003687549.1 677986 D 754252 CDS YP_003687550.1 297625787 9284252 678293..678778 1 NC_014215.1 50S ribosomal protein L22 678778 rplV 9284252 rplV Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L22 YP_003687550.1 678293 D 754252 CDS YP_003687551.1 297625788 9284218 678781..679599 1 NC_014215.1 30S ribosomal protein S3 679599 rpsC 9284218 rpsC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S3 YP_003687551.1 678781 D 754252 CDS YP_003687552.1 297625789 9284237 679605..680024 1 NC_014215.1 highly similar to SwissProt entry RL16_PROAC from Propionibacterium acnes; 50S ribosomal protein L16 680024 rplP 9284237 rplP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L16 YP_003687552.1 679605 D 754252 CDS YP_003687553.1 297625790 9284212 680026..680274 1 NC_014215.1 50S ribosomal protein L29 680274 rpmC 9284212 rpmC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L29 YP_003687553.1 680026 D 754252 CDS YP_003687554.1 297625791 9284224 680271..680546 1 NC_014215.1 highly similar to Swissprot entry RS17_PROAC from Propionibacterium acnes; 30S ribosomal protein S17 680546 rpsQ 9284224 rpsQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S17 YP_003687554.1 680271 D 754252 CDS YP_003687555.1 297625792 9284250 680677..681048 1 NC_014215.1 50S ribosomal protein L14 681048 rplN 9284250 rplN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L14 YP_003687555.1 680677 D 754252 CDS YP_003687556.1 297625793 9284210 681050..681421 1 NC_014215.1 50S ribosomal protein L24 681421 rplX 9284210 rplX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L24 YP_003687556.1 681050 D 754252 CDS YP_003687557.1 297625794 9284220 681421..682083 1 NC_014215.1 50S ribosomal protein L5 682083 rplE 9284220 rplE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L5 YP_003687557.1 681421 D 754252 CDS YP_003687558.1 297625795 9284203 682092..682277 1 NC_014215.1 30S ribosomal protein S14 682277 rpsN1 9284203 rpsN1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S14 YP_003687558.1 682092 D 754252 CDS YP_003687559.1 297625796 9284247 682437..682844 1 NC_014215.1 30S ribosomal protein S8 682844 rpsH 9284247 rpsH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S8 YP_003687559.1 682437 D 754252 CDS YP_003687560.1 297625797 9284242 682875..683417 1 NC_014215.1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center, Part of the 50S ribosomal subunit, elongs to the ribosomal protein L6P family; 50S ribosomal protein L6 683417 rplF 9284242 rplF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L6 YP_003687560.1 682875 D 754252 CDS YP_003687561.1 297625798 9284204 683420..683803 1 NC_014215.1 50S ribosomal protein L18 683803 rplR 9284204 rplR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L18 YP_003687561.1 683420 D 754252 CDS YP_003687562.1 297625799 9284214 683757..684437 1 NC_014215.1 30S ribosomal protein S5 684437 rpsE 9284214 rpsE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S5 YP_003687562.1 683757 D 754252 CDS YP_003687563.1 297625800 9284239 684437..684619 1 NC_014215.1 50S ribosomal protein L30 684619 rpmD 9284239 rpmD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L30 YP_003687563.1 684437 D 754252 CDS YP_003687564.1 297625801 9284225 684621..685064 1 NC_014215.1 50S ribosomal protein L15 685064 rplO 9284225 rplO Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L15 YP_003687564.1 684621 D 754252 CDS YP_003687565.1 297625802 9284211 complement(685421..686068) 1 NC_014215.1 NAD(P)H-dependent FMN reductase 686068 9284211 PFREUD_05910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NAD(P)H-dependent FMN reductase YP_003687565.1 685421 R 754252 CDS YP_003687566.1 297625803 9282344 complement(686179..687375) 1 NC_014215.1 5,10-methylenetetrahydromethanopterin + Coenzyme F420 <=> 5,10-methenyltetrahydromethanopterin + Reduced coenzyme F420; coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase 687375 mer 9282344 mer Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase YP_003687566.1 686179 R 754252 CDS YP_003687567.1 297625804 9283870 complement(687626..689344) 1 NC_014215.1 ABC transporter substrate-binding protein 689344 bopA 9283870 bopA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter substrate-binding protein YP_003687567.1 687626 R 754252 CDS YP_003687568.1 297625805 9283383 complement(689415..691514) 1 NC_014215.1 ABC transporter ATPase 691514 9283383 PFREUD_05940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATPase YP_003687568.1 689415 R 754252 CDS YP_003687569.1 297625806 9282345 complement(691511..692497) 1 NC_014215.1 ABC transporter permease 692497 oppC 9282345 oppC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687569.1 691511 R 754252 CDS YP_003687570.1 297625807 9283983 complement(692499..693629) 1 NC_014215.1 ABC transporter 693629 9283983 PFREUD_05960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687570.1 692499 R 754252 CDS YP_003687571.1 297625808 9282346 693872..695185 1 NC_014215.1 Involved in protein export. Interacts with secA and secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel. One of seven secretory proteins (secA-F and secY) that comprise the prokaryotic protein translocation apparatus. cell membrane; Multi-pass membrane protein.; preprotein translocase subunit SecY 695185 secY 9282346 secY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 preprotein translocase subunit SecY YP_003687571.1 693872 D 754252 CDS YP_003687572.1 297625809 9284274 695182..695757 1 NC_014215.1 ATP + AMP = 2 ADP.; adenylate kinase 695757 adk 9284274 adk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 adenylate kinase YP_003687572.1 695182 D 754252 CDS YP_003687573.1 297625810 9283301 695754..696599 1 NC_014215.1 Removes the amino-terminal methionine from nascent proteins. Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. Binds 2 cobalt ions per subunit. Belongs to the peptidase M24A family; methionine aminopeptidase 696599 map 9283301 map Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionine aminopeptidase YP_003687573.1 695754 D 754252 CDS YP_003687574.1 297625811 9283855 696625..697011 1 NC_014215.1 hypothetical protein 697011 9283855 PFREUD_06000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687574.1 696625 D 754252 CDS YP_003687575.1 297625812 9282347 complement(697042..697326) 1 NC_014215.1 hypothetical protein 697326 9282347 PFREUD_06010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687575.1 697042 R 754252 CDS YP_003687576.1 297625813 9282348 697685..697906 1 NC_014215.1 translation initiation factor IF-1 697906 infA 9282348 infA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 translation initiation factor IF-1 YP_003687576.1 697685 D 754252 CDS YP_003687577.1 297625814 9283744 697999..698112 1 NC_014215.1 hypothetical protein 698112 9283744 PFREUD_06030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687577.1 697999 D 754252 CDS YP_003687578.1 297625815 9282349 698365..698739 1 NC_014215.1 highly similar to SwissProt entry RS13_BIFLO from Bifidobacterium longum; 30S ribosomal protein S13 698739 rpsM 9282349 rpsM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S13 YP_003687578.1 698365 D 754252 CDS YP_003687579.1 297625816 9284246 698785..699192 1 NC_014215.1 30S ribosomal protein S11 699192 rpsK 9284246 rpsK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S11 YP_003687579.1 698785 D 754252 CDS YP_003687580.1 297625817 9284244 699223..699828 1 NC_014215.1 30S ribosomal protein S4 699828 rpsD 9284244 rpsD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S4 YP_003687580.1 699223 D 754252 CDS YP_003687581.1 297625818 9284238 699953..700972 1 NC_014215.1 DNA-directed RNA polymerase subunit alpha 700972 rpoA 9284238 rpoA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA-directed RNA polymerase subunit alpha YP_003687581.1 699953 D 754252 CDS YP_003687582.1 297625819 9284229 701016..701603 1 NC_014215.1 50S ribosomal protein L17 701603 rplQ 9284229 rplQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L17 YP_003687582.1 701016 D 754252 CDS YP_003687583.1 297625820 9284213 701740..702885 1 NC_014215.1 transferase activity transferring glycosyl groups; glycosyltransferase 702885 gtfE 9284213 gtfE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyltransferase YP_003687583.1 701740 D 754252 CDS YP_003687584.1 297625821 9283671 complement(702981..704066) 1 NC_014215.1 Resuscitation-promoting factor RpfB 704066 9283671 PFREUD_06100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Resuscitation-promoting factor RpfB YP_003687584.1 702981 R 754252 CDS YP_003687585.1 297625822 9282350 complement(704360..704968) 1 NC_014215.1 superoxide dismutase 704968 sodA 9282350 sodA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 superoxide dismutase YP_003687585.1 704360 R 754252 CDS YP_003687586.1 297625823 9284289 705167..706207 1 NC_014215.1 ABC transporter ATP-binding protein 706207 9284289 PFREUD_06120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687586.1 705167 D 754252 CDS YP_003687587.1 297625824 9282351 706177..707769 1 NC_014215.1 ABC transporter 707769 9282351 PFREUD_06130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687587.1 706177 D 754252 CDS YP_003687588.1 297625825 9282352 complement(707784..708635) 1 NC_014215.1 ABC transporter permease 708635 pf2694 9282352 pf2694 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687588.1 707784 R 754252 CDS YP_003687589.1 297625826 9284043 complement(708632..710248) 1 NC_014215.1 cobalt ABC transporter ATP-binding protein 710248 cbiO2 9284043 cbiO2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt ABC transporter ATP-binding protein YP_003687589.1 708632 R 754252 CDS YP_003687590.1 297625827 9283406 complement(710245..711378) 1 NC_014215.1 ABC transporter permease 711378 9283406 PFREUD_06160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687590.1 710245 R 754252 CDS YP_003687591.1 297625828 9282353 complement(711391..711942) 1 NC_014215.1 hypothetical protein 711942 9282353 PFREUD_06170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687591.1 711391 R 754252 CDS YP_003687593.1 297625830 9282355 complement(712252..712881) 1 NC_014215.1 methyltransferase 712881 9282355 PFREUD_06190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003687593.1 712252 R 754252 CDS YP_003687594.1 297625831 9282356 complement(712889..713767) 1 NC_014215.1 tRNA uridine <=> tRNA pseudouridine; tRNA pseudouridine synthase A 713767 truA 9282356 truA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA pseudouridine synthase A YP_003687594.1 712889 R 754252 CDS YP_003687595.1 297625832 9284433 complement(713760..714614) 1 NC_014215.1 S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine; tRNA (guanine-N(7)-)-methyltransferase 714614 trmB 9284433 trmB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA (guanine-N(7)-)-methyltransferase YP_003687595.1 713760 R 754252 CDS YP_003687596.1 297625833 9284423 714824..715222 1 NC_014215.1 hypothetical protein 715222 9284423 PFREUD_06220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687596.1 714824 D 754252 CDS YP_003687597.1 297625834 9282357 complement(715354..717471) 1 NC_014215.1 GTP + H2O <=> GDP + Orthophosphate; GTP phosphohydrolase 717471 9282357 PFREUD_06230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP phosphohydrolase YP_003687597.1 715354 R 754252 CDS YP_003687598.1 297625835 9282358 717751..718194 1 NC_014215.1 50S ribosomal protein L13 718194 rplM 9282358 rplM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L13 YP_003687598.1 717751 D 754252 CDS YP_003687599.1 297625836 9284209 718191..718742 1 NC_014215.1 30S ribosomal protein S9 718742 rspI 9284209 rspI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S9 YP_003687599.1 718191 D 754252 CDS YP_003687600.1 297625837 9284255 718866..720236 1 NC_014215.1 alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate; phosphoglucosamine mutase 720236 glmM 9284255 glmM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglucosamine mutase YP_003687600.1 718866 D 754252 CDS YP_003687601.1 297625838 9283619 complement(720375..721457) 1 NC_014215.1 ATP + (R)-pantothenate = ADP + (R)-4-phosphopantothenate; pantothenate kinase 721457 coaA 9283619 coaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pantothenate kinase YP_003687601.1 720375 R 754252 CDS YP_003687602.1 297625839 9283429 721612..723456 1 NC_014215.1 * L-glutamine + D-Fructose 6-phosphate <=> L-glutamate + D-glucosamine 6-phosphate . Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 723456 glmS 9283429 glmS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glucosamine--fructose-6-phosphate aminotransferase YP_003687602.1 721612 D 754252 CDS YP_003687603.1 297625840 9283620 723497..723964 1 NC_014215.1 CoA + Apo-ACP <=> adenosine 3prime,5prime-bisphosphate + acyl-carrier protein; phosphopantethiene--protein transferase 723964 acpS 9283620 acpS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphopantethiene--protein transferase YP_003687603.1 723497 D 754252 CDS YP_003687604.1 297625841 9283293 723966..725384 1 NC_014215.1 carbohydrate kinase 725384 9283293 PFREUD_06300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbohydrate kinase YP_003687604.1 723966 D 754252 CDS YP_003687605.1 297625842 9282359 complement(725413..726558) 1 NC_014215.1 glycosyl transferases group 1; glycosyltransferase 726558 sqdX 9282359 sqdX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyltransferase YP_003687605.1 725413 R 754252 CDS YP_003687606.1 297625843 9284298 726836..729967 1 NC_014215.1 hypothetical protein 729967 9284298 PFREUD_06320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687606.1 726836 D 754252 CDS YP_003687607.1 297625844 9282360 730230..731225 1 NC_014215.1 hypothetical protein 731225 9282360 PFREUD_06330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687607.1 730230 D 754252 CDS YP_003687608.1 297625845 9282361 731222..731908 1 NC_014215.1 peptidase, family M22 731908 9282361 PFREUD_06340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase, family M22 YP_003687608.1 731222 D 754252 CDS YP_003687609.1 297625846 9282362 731905..732426 1 NC_014215.1 acetyl-CoA + ribosomal-protein L-alanine <=> CoA + ribosomal-protein N-acetyl-L-alanine; ribosomal-protein-alanine acetyltransferase 732426 rimI 9282362 rimI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribosomal-protein-alanine acetyltransferase YP_003687609.1 731905 D 754252 CDS YP_003687610.1 297625847 9284179 732423..733496 1 NC_014215.1 Could be a metalloprotease.Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. Belongs to the peptidase M22 family.; O-sialoglycoprotein endopeptidase 733496 gcp 9284179 gcp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 O-sialoglycoprotein endopeptidase YP_003687610.1 732423 D 754252 CDS YP_003687611.1 297625848 9283603 733570..735450 1 NC_014215.1 phosphoribosyltransferase/nitroreductase 735450 bluB/cobT2 9283603 bluB/cobT2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosyltransferase/nitroreductase YP_003687611.1 733570 D 754252 CDS YP_003687612.1 297625849 9283382 735634..737082 1 NC_014215.1 nactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred. Belongs to the peptidase C1 family.; aminopeptidase 737082 pepC 9283382 pepC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminopeptidase YP_003687612.1 735634 D 754252 CDS YP_003687613.1 297625850 9284026 737137..737622 1 NC_014215.1 8-dihydro-8-oxoguanine-triphosphatase 737622 mutT 9284026 mutT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 8-dihydro-8-oxoguanine-triphosphatase YP_003687613.1 737137 D 754252 CDS YP_003687614.1 297625851 9283930 737766..739061 1 NC_014215.1 major facilitator super family protein 739061 9283930 PFREUD_06400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 major facilitator super family protein YP_003687614.1 737766 D 754252 CDS YP_003687615.1 297625852 9282363 739086..740456 1 NC_014215.1 hypothetical protein 740456 9282363 PFREUD_06410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687615.1 739086 D 754252 CDS YP_003687616.1 297625853 9282364 740668..741309 1 NC_014215.1 ABC transporter permease 741309 opuCB 9282364 opuCB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687616.1 740668 D 754252 CDS YP_003687617.1 297625854 9283986 741306..742640 1 NC_014215.1 glycine betaine/carnitine/choline transport ATP-binding protein opuCA 742640 opuCA 9283986 opuCA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine betaine/carnitine/choline transport ATP-binding protein opuCA YP_003687617.1 741306 D 754252 CDS YP_003687618.1 297625855 9283985 742637..743374 1 NC_014215.1 permease membrane component ABC transporter OpuBB 743374 opuBB 9283985 opuBB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 permease membrane component ABC transporter OpuBB YP_003687618.1 742637 D 754252 CDS YP_003687619.1 297625856 9283984 743378..744409 1 NC_014215.1 ABC transporter permease 744409 9283984 PFREUD_06450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687619.1 743378 D 754252 CDS YP_003687620.1 297625857 9282365 744646..744942 1 NC_014215.1 heat shock protein 10 744942 groS1 9282365 groS1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 heat shock protein 10 YP_003687620.1 744646 D 754252 CDS YP_003687621.1 297625858 9283662 744964..746556 1 NC_014215.1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. groL1 and groL2 are expressed as 2 distinct heat shock proteins; molecular chaperone GroEL 746556 groL1 9283662 groL1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone GroEL YP_003687621.1 744964 D 754252 CDS YP_003687622.1 297625859 9283660 complement(746660..747700) 1 NC_014215.1 integrase 747700 int 9283660 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003687622.1 746660 R 754252 CDS YP_003687623.1 297625860 9283771 747801..749321 1 NC_014215.1 IMP + NAD+ + H2O <=> Xanthosine 5 prime-phosphate + NADH + H+; inosine-5'-monophosphate dehydrogenase 749321 guaB1 9283771 guaB1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inosine-5'-monophosphate dehydrogenase YP_003687623.1 747801 D 754252 CDS YP_003687624.1 297625861 9283675 749473..750576 1 NC_014215.1 inosine-5'-monophosphate dehydrogenase 750576 guaB2 9283675 guaB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inosine-5'-monophosphate dehydrogenase YP_003687624.1 749473 D 754252 CDS YP_003687625.1 297625862 9283676 750607..750936 1 NC_014215.1 Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine; chorismate mutase 750936 9283676 PFREUD_06500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chorismate mutase YP_003687625.1 750607 D 754252 CDS YP_003687626.1 297625863 9282366 751240..752556 1 NC_014215.1 transcription initiation factor 752556 9282366 PFREUD_06510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription initiation factor YP_003687626.1 751240 D 754252 CDS YP_003687627.1 297625864 9282367 752581..754284 1 NC_014215.1 hypothetical protein 754284 9282367 PFREUD_06520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687627.1 752581 D 754252 CDS YP_003687628.1 297625865 9282368 754297..755367 1 NC_014215.1 hypothetical protein 755367 9282368 PFREUD_06530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687628.1 754297 D 754252 CDS YP_003687629.1 297625866 9282369 755357..756274 1 NC_014215.1 N-acetylmuramoyl-L-alanine amidase 756274 amiC 9282369 amiC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 N-acetylmuramoyl-L-alanine amidase YP_003687629.1 755357 D 754252 CDS YP_003687630.1 297625867 9283311 complement(756309..756860) 1 NC_014215.1 L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA; serine acetyltransferase 756860 cysE 9283311 cysE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 serine acetyltransferase YP_003687630.1 756309 R 754252 CDS YP_003687631.1 297625868 9283461 complement(756857..757783) 1 NC_014215.1 cysteine synthase 757783 cys1 9283461 cys1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cysteine synthase YP_003687631.1 756857 R 754252 CDS YP_003687632.1 297625869 9283319 759751..760398 1 NC_014215.1 L-ribulose 5-phosphate = D-xylulose 5-phosphate. L-arabinose catabolism; third step. Belongs to the aldolase class II family. AraD/fucA subfamily. The Bacillus subtilis L-arabinose (ara) operon: nucleotide sequence, genetic organization and expression. Microbiology 143,957-969(1997).; L-ribulose-5-phosphate 4-epimerase 760398 araD1 9283319 araD1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-ribulose-5-phosphate 4-epimerase YP_003687632.1 759751 D 754252 CDS YP_003687633.1 297625870 9283325 760358..760456 1 NC_014215.1 hypothetical protein 760456 9283325 PFREUD_06600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687633.1 760358 D 754252 CDS YP_003687634.1 297625871 9282370 760526..762046 1 NC_014215.1 L-arabinose = L-ribulose. L-arabinose catabolism; first step. Belongs to the arabinose isomerase family. This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into L-ribulose by the L-arabinose isomerases enzyme.; L-arabinose isomerase 762046 araA 9282370 araA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-arabinose isomerase YP_003687634.1 760526 D 754252 CDS YP_003687635.1 297625872 9283317 762073..763110 1 NC_014215.1 arabinose operon repressor 763110 lacI1 9283317 lacI1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arabinose operon repressor YP_003687635.1 762073 D 754252 CDS YP_003687636.1 297625873 9283808 763354..764334 1 NC_014215.1 locus abc transport; ABC transporter 764334 biaA 9283808 biaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687636.1 763354 D 754252 CDS YP_003687637.1 297625874 9283376 764472..766004 1 NC_014215.1 Molecular function: ATP binding. Responsible for energy coupling to the transport system; ABC transporter 766004 9283376 PFREUD_06640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687637.1 764472 D 754252 CDS YP_003687638.1 297625875 9284493 766375..767058 1 NC_014215.1 sugar ABC transporter permease 767058 9284493 PFREUD_06660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar ABC transporter permease YP_003687638.1 766375 D 754252 CDS YP_003687639.1 297625876 9282372 767055..768083 1 NC_014215.1 locus abc transport.; sugar ABC transporter 768083 9282372 PFREUD_06670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar ABC transporter YP_003687639.1 767055 D 754252 CDS YP_003687640.1 297625877 9282373 768378..769931 1 NC_014215.1 glutamine amidotransferase 769931 guaA 9282373 guaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine amidotransferase YP_003687640.1 768378 D 754252 CDS YP_003687641.1 297625878 9283674 770136..771023 1 NC_014215.1 hypothetical protein 771023 9283674 PFREUD_06690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687641.1 770136 D 754252 CDS YP_003687642.1 297625879 9282374 complement(771074..772006) 1 NC_014215.1 Zn-dependent oxidoreductase 772006 9282374 PFREUD_06700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Zn-dependent oxidoreductase YP_003687642.1 771074 R 754252 CDS YP_003687643.1 297625880 9282375 complement(772315..772650) 1 NC_014215.1 transcriptional regulator 772650 pspC 9282375 pspC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687643.1 772315 R 754252 CDS YP_003687644.1 297625881 9284129 772847..774190 1 NC_014215.1 two-component system sensor kinase 774190 9284129 PFREUD_06720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system sensor kinase YP_003687644.1 772847 D 754252 CDS YP_003687645.1 297625882 9282376 774187..774885 1 NC_014215.1 LuxR family transcriptional regulator 774885 luxR 9282376 luxR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LuxR family transcriptional regulator YP_003687645.1 774187 D 754252 CDS YP_003687646.1 297625883 9283839 complement(775122..775373) 1 NC_014215.1 hypothetical protein 775373 9283839 PFREUD_06740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687646.1 775122 R 754252 CDS YP_003687647.1 297625884 9282377 775663..776679 1 NC_014215.1 iron ABC transporter substrate-binding protein 776679 feuS 9282377 feuS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 iron ABC transporter substrate-binding protein YP_003687647.1 775663 D 754252 CDS YP_003687648.1 297625885 9283553 776751..777692 1 NC_014215.1 iron ABC transporter permease 777692 9283553 PFREUD_06760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 iron ABC transporter permease YP_003687648.1 776751 D 754252 CDS YP_003687649.1 297625886 9282378 777762..778802 1 NC_014215.1 cobalamin/Fe3+-siderophore ABC transporter permease 778802 feuC 9282378 feuC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalamin/Fe3+-siderophore ABC transporter permease YP_003687649.1 777762 D 754252 CDS YP_003687650.1 297625887 9283552 778817..779554 1 NC_014215.1 highly similar to Q411B6_KINRA from Kineococcus radiotolerans SRS30216 and COG domain; ABC transporter 779554 9283552 PFREUD_06780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687650.1 778817 D 754252 CDS YP_003687651.1 297625888 9282379 complement(779627..780880) 1 NC_014215.1 phospholipase D/transphosphatidylase 780880 9282379 PFREUD_06790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phospholipase D/transphosphatidylase YP_003687651.1 779627 R 754252 CDS YP_003687652.1 297625889 9282380 781017..783506 1 NC_014215.1 ATP-dependent DNA helicase 783506 pcrA 9282380 pcrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent DNA helicase YP_003687652.1 781017 D 754252 CDS YP_003687653.1 297625890 9284004 783600..785078 1 NC_014215.1 hypothetical protein 785078 9284004 PFREUD_06810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687653.1 783600 D 754252 CDS YP_003687654.1 297625891 9282381 785089..785700 1 NC_014215.1 10-formyltetrahydrofolate + 5prim-phosphoribosylglycinamide <=> Tetrahydrofolate + 5prim-phosphoribosyl-N-formylglycinamide and 5prim-phosphoribosylglycinamide + 5,10-methenyltetrahydrofolate + H2O <=> 5prim-phosphoribosyl-N-formylglycinamide + Tetrahydrofolate; 5-phosphoribosylglycinamide formyltransferase 785700 purN 9282381 purN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 5-phosphoribosylglycinamide formyltransferase YP_003687654.1 785089 D 754252 CDS YP_003687655.1 297625892 9284149 785822..787375 1 NC_014215.1 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide and IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; phosphoribosylaminoimidazolecarboxamide formyltransferase 787375 purH 9284149 purH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylaminoimidazolecarboxamide formyltransferase YP_003687655.1 785822 D 754252 CDS YP_003687656.1 297625893 9284144 787449..788309 1 NC_014215.1 5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH + H+ / Tetrahydrofolate + formate + ATP <=> ADP + Orthophosphate + 10-formyltetrahydrofolate; methylenetetrahydrofolate dehydrogenase 788309 folD 9284144 folD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylenetetrahydrofolate dehydrogenase YP_003687656.1 787449 D 754252 CDS YP_003687657.1 297625894 9283569 788315..788638 1 NC_014215.1 hypothetical protein 788638 9283569 PFREUD_06850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687657.1 788315 D 754252 CDS YP_003687658.1 297625895 9282382 complement(788820..789806) 1 NC_014215.1 (S)-malate + NAD+ = oxaloacetate + NADH.; malate dehydrogenase 789806 mdh 9282382 mdh Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 malate dehydrogenase YP_003687658.1 788820 R 754252 CDS YP_003687659.1 297625896 9283862 789984..791201 1 NC_014215.1 Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+; isocitrate/isopropylmalate dehydrogenase 791201 icd 9283862 icd Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 isocitrate/isopropylmalate dehydrogenase YP_003687659.1 789984 D 754252 CDS YP_003687660.1 297625897 9283732 complement(791362..791673) 1 NC_014215.1 hypothetical protein 791673 9283732 PFREUD_06880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687660.1 791362 R 754252 CDS YP_003687661.1 297625898 9282383 complement(791670..792338) 1 NC_014215.1 amino acid ABC transporter permease 792338 azlC 9282383 azlC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003687661.1 791670 R 754252 CDS YP_003687662.1 297625899 9283373 792632..794152 1 NC_014215.1 hypothetical protein 794152 9283373 PFREUD_06900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687662.1 792632 D 754252 CDS YP_003687663.1 297625900 9282384 794233..795522 1 NC_014215.1 no signal peptid, no TM domain; hypothetical protein 795522 9282384 PFREUD_06910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687663.1 794233 D 754252 CDS YP_003687664.1 297625901 9282385 795652..796716 1 NC_014215.1 hypothetical protein 796716 9282385 PFREUD_06920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687664.1 795652 D 754252 CDS YP_003687665.1 297625902 9282386 796788..797819 1 NC_014215.1 Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; ribonuclease H 797819 rnhA 9282386 rnhA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease H YP_003687665.1 796788 D 754252 CDS YP_003687666.1 297625903 9284191 797896..798411 1 NC_014215.1 hypothetical protein 798411 9284191 PFREUD_06940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687666.1 797896 D 754252 CDS YP_003687667.1 297625904 9282387 complement(798488..799420) 1 NC_014215.1 enoyl-CoA hydratase/carnithine racemase 799420 caiD 9282387 caiD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 enoyl-CoA hydratase/carnithine racemase YP_003687667.1 798488 R 754252 CDS YP_003687668.1 297625905 9283391 799728..801407 1 NC_014215.1 methionyl-tRNA synthetase 801407 metG 9283391 metG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionyl-tRNA synthetase YP_003687668.1 799728 D 754252 CDS YP_003687669.1 297625906 9283879 801649..802572 1 NC_014215.1 atalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.; Silent information regulator protein Sir2 NAD-dependent deacetylase 802572 9283879 PFREUD_06970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Silent information regulator protein Sir2 NAD-dependent deacetylase YP_003687669.1 801649 D 754252 CDS YP_003687670.1 297625907 9282388 complement(802591..803235) 1 NC_014215.1 hypothetical protein 803235 9282388 PFREUD_06980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687670.1 802591 R 754252 CDS YP_003687671.1 297625908 9282389 complement(803232..803687) 1 NC_014215.1 hypothetical protein 803687 9282389 PFREUD_06990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687671.1 803232 R 754252 CDS YP_003687672.1 297625909 9282390 complement(803860..804225) 1 NC_014215.1 MerR family transcriptional regulator 804225 soxR 9282390 soxR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MerR family transcriptional regulator YP_003687672.1 803860 R 754252 CDS YP_003687673.1 297625910 9284290 804338..804745 1 NC_014215.1 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 2-Oxo-2,3-dihydrofuran-5-acetate + CO2; 4-carboxymuconolactone decarboxylase 804745 pcaC1 9284290 pcaC1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-carboxymuconolactone decarboxylase YP_003687673.1 804338 D 754252 CDS YP_003687674.1 297625911 9284000 804742..804912 1 NC_014215.1 hypothetical protein 804912 9284000 PFREUD_07020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687674.1 804742 D 754252 CDS YP_003687675.1 297625912 9282391 complement(806044..806664) 1 NC_014215.1 N-acetyltransferase GCN5 806664 9282391 PFREUD_07030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 N-acetyltransferase GCN5 YP_003687675.1 806044 R 754252 CDS YP_003687676.1 297625913 9282392 806985..807383 1 NC_014215.1 hypothetical protein 807383 9282392 PFREUD_07040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687676.1 806985 D 754252 CDS YP_003687677.1 297625914 9282393 complement(807515..808558) 1 NC_014215.1 zinc-binding dehydrogenase 808558 9282393 PFREUD_07050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 zinc-binding dehydrogenase YP_003687677.1 807515 R 754252 CDS YP_003687678.1 297625915 9282394 complement(808696..810483) 1 NC_014215.1 hypothetical protein 810483 9282394 PFREUD_07060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687678.1 808696 R 754252 CDS YP_003687679.1 297625916 9282395 810795..814514 1 NC_014215.1 pyruvate:ferredoxin (Flavodoxin) oxidoreductase 814514 nifJ2 9282395 nifJ2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyruvate:ferredoxin (Flavodoxin) oxidoreductase YP_003687679.1 810795 D 754252 CDS YP_003687680.1 297625917 9283950 814518..815525 1 NC_014215.1 (S)-dihydroorotate + Oxygen <=> Orotate + H2O2; dihydroorotate dehydrogenase 815525 9283950 PFREUD_07080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroorotate dehydrogenase YP_003687680.1 814518 D 754252 CDS YP_003687681.1 297625918 9282396 complement(815553..816095) 1 NC_014215.1 hypothetical protein 816095 9282396 PFREUD_07090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687681.1 815553 R 754252 CDS YP_003687682.1 297625919 9282397 complement(816148..817929) 1 NC_014215.1 ATP + acetyl-CoA + HCO(3)(-) <=> ADP + phosphate + malonyl-CoA; acetyl-CoA carboxylase 817929 accA 9282397 accA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyl-CoA carboxylase YP_003687682.1 816148 R 754252 CDS YP_003687683.1 297625920 9283288 complement(818085..818900) 1 NC_014215.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates; formamidopyrimidine-DNA glycosylase 818900 mutM2 9283288 mutM2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 formamidopyrimidine-DNA glycosylase YP_003687683.1 818085 R 754252 CDS YP_003687684.1 297625921 9283928 complement(819051..819164) 1 NC_014215.1 hypothetical protein 819164 9283928 PFREUD_07120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687684.1 819051 R 754252 CDS YP_003687685.1 297625922 9282398 819547..820026 1 NC_014215.1 hypothetical protein 820026 9282398 PFREUD_07130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687685.1 819547 D 754252 CDS YP_003687686.1 297625923 9282399 complement(820117..820617) 1 NC_014215.1 NUDIX hydrolase 820617 9282399 PFREUD_07140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003687686.1 820117 R 754252 CDS YP_003687687.1 297625924 9282400 complement(820621..821349) 1 NC_014215.1 implicated in inhibition of septum; Maf-like protein 821349 maf 9282400 maf Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Maf-like protein YP_003687687.1 820621 R 754252 CDS YP_003687688.1 297625925 9283847 complement(821400..821654) 1 NC_014215.1 hypothetical protein 821654 9283847 PFREUD_07160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687688.1 821400 R 754252 CDS YP_003687689.1 297625926 9282401 complement(821660..823234) 1 NC_014215.1 ATP + propanoyl-CoA + HCO(3)(-) <=> ADP + phosphate + (S)-methylmalonyl-CoA; propionyl-CoA carboxylase subunit beta 823234 pccB 9282401 pccB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propionyl-CoA carboxylase subunit beta YP_003687689.1 821660 R 754252 CDS YP_003687690.1 297625927 9284002 823366..824712 1 NC_014215.1 hypothetical protein 824712 9284002 PFREUD_07180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687690.1 823366 D 754252 CDS YP_003687691.1 297625928 9282403 complement(825374..826456) 1 NC_014215.1 tetronasin ABC transporter 826456 9282403 PFREUD_07200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tetronasin ABC transporter YP_003687691.1 825374 R 754252 CDS YP_003687692.1 297625929 9282404 complement(826453..827397) 1 NC_014215.1 ABC transporter ATP-binding protein 827397 9282404 PFREUD_07210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687692.1 826453 R 754252 CDS YP_003687693.1 297625930 9282405 827502..828020 1 NC_014215.1 hypothetical protein 828020 9282405 PFREUD_07220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687693.1 827502 D 754252 CDS YP_003687694.1 297625931 9282406 828135..828713 1 NC_014215.1 transcriptional regulator 828713 9282406 PFREUD_07230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687694.1 828135 D 754252 CDS YP_003687695.1 297625932 9282407 complement(828727..829320) 1 NC_014215.1 TetR family transcriptional regulator 829320 9282407 PFREUD_07240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003687695.1 828727 R 754252 CDS YP_003687696.1 297625933 9282408 829482..830273 1 NC_014215.1 biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. ATP + biotin + Apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] <=> AMP + Pyrophosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]; biotin-(acetyl-CoA carboxylase) ligase 830273 birA 9282408 birA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 biotin-(acetyl-CoA carboxylase) ligase YP_003687696.1 829482 D 754252 CDS YP_003687697.1 297625934 9283378 830307..830810 1 NC_014215.1 hypothetical protein 830810 9283378 PFREUD_07260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687697.1 830307 D 754252 CDS YP_003687699.1 297625936 9282410 830892..831476 1 NC_014215.1 TetR family transcriptional regulator 831476 9282410 PFREUD_07280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003687699.1 830892 D 754252 CDS YP_003687700.1 297625937 9282411 complement(831546..832262) 1 NC_014215.1 peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly. type 1 glutamine amidotransferase; peptidase S51 832262 9282411 PFREUD_07290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase S51 YP_003687700.1 831546 R 754252 CDS YP_003687701.1 297625938 9282412 832331..833512 1 NC_014215.1 phosphoribosylaminoimidazole carboxylase ATPase subunit 833512 purK 9282412 purK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_003687701.1 832331 D 754252 CDS YP_003687702.1 297625939 9284145 833505..834065 1 NC_014215.1 1-(5-phospho-D-ribosyl)-5-amino-4- imidazolecarboxylate <=> aminoimidazole ribotide + CO2; phosphoribosylaminoimidazole carboxylase catalytic subunit 834065 purE 9284145 purE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_003687702.1 833505 D 754252 CDS YP_003687703.1 297625940 9284142 complement(834103..835461) 1 NC_014215.1 transcriptional regulator 835461 9284142 PFREUD_07320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687703.1 834103 R 754252 CDS YP_003687704.1 297625941 9282413 835587..836666 1 NC_014215.1 mannose-1-phosphate guanylyltransferase 836666 manC 9282413 manC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 mannose-1-phosphate guanylyltransferase YP_003687704.1 835587 D 754252 CDS YP_003687705.1 297625942 9283852 836663..837745 1 NC_014215.1 hypothetical protein 837745 9283852 PFREUD_07340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687705.1 836663 D 754252 CDS YP_003687706.1 297625943 9282414 838078..838338 1 NC_014215.1 highly similar to A0LS21 from Acidothermus cellulolyticus (strain ATCC 43068 / 11B); transcription factor WhiB 838338 whiB1 9282414 whiB1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription factor WhiB YP_003687706.1 838078 D 754252 CDS YP_003687707.1 297625944 9284473 838535..841786 1 NC_014215.1 glycosyltransferase 841786 9284473 PFREUD_07360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyltransferase YP_003687707.1 838535 D 754252 CDS YP_003687708.1 297625945 9282415 841783..843135 1 NC_014215.1 hypothetical protein 843135 9282415 PFREUD_07370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687708.1 841783 D 754252 CDS YP_003687709.1 297625946 9282416 complement(843240..843680) 1 NC_014215.1 hypothetical protein 843680 9282416 PFREUD_07380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687709.1 843240 R 754252 CDS YP_003687710.1 297625947 9282417 843903..844247 1 NC_014215.1 hypothetical protein 844247 9282417 PFREUD_07390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687710.1 843903 D 754252 CDS YP_003687711.1 297625948 9282418 844363..845178 1 NC_014215.1 alpha-D-mannose 1-phosphate = D-mannose 6-phosphate; phosphomannomutase 845178 pmm 9282418 pmm Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphomannomutase YP_003687711.1 844363 D 754252 CDS YP_003687712.1 297625949 9284084 845239..845439 1 NC_014215.1 hypothetical protein 845439 9284084 PFREUD_07410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687712.1 845239 D 754252 CDS YP_003687713.1 297625950 9282419 845447..846463 1 NC_014215.1 hypothetical protein 846463 9282419 PFREUD_07420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687713.1 845447 D 754252 CDS YP_003687714.1 297625951 9282420 846536..847615 1 NC_014215.1 Cation transport protein 847615 9282420 PFREUD_07430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cation transport protein YP_003687714.1 846536 D 754252 CDS YP_003687715.1 297625952 9282421 complement(847771..848034) 1 NC_014215.1 hypothetical protein 848034 9282421 PFREUD_07440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687715.1 847771 R 754252 CDS YP_003687716.1 297625953 9282422 848165..849604 1 NC_014215.1 transmembrane transport protein 849604 9282422 PFREUD_07450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transmembrane transport protein YP_003687716.1 848165 D 754252 CDS YP_003687717.1 297625954 9282423 849778..850830 1 NC_014215.1 pfam06271, RDD family. This family of proteins contain 3 highly conserved amino acids: one arginine and two aspartates. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown but may be involved in transport of an as yet unknown set of ligands; hypothetical protein 850830 9282423 PFREUD_07460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687717.1 849778 D 754252 CDS YP_003687718.1 297625955 9282424 850960..853149 1 NC_014215.1 transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.; 4-alpha-glucanotransferase 853149 malQ1 9282424 malQ1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-alpha-glucanotransferase YP_003687718.1 850960 D 754252 CDS YP_003687719.1 297625956 9283848 853146..854144 1 NC_014215.1 1R,6R)-6-hydroxy-2-succinylcyclohexa-2, 4-diene-1-carboxylate = 2-succinylbenzoate + H2O.; O-succinylbenzoate-CoA synthase 854144 menC 9283848 menC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 O-succinylbenzoate-CoA synthase YP_003687719.1 853146 D 754252 CDS YP_003687720.1 297625957 9283865 854269..855924 1 NC_014215.1 2-Oxoglutarate + Isochorismate <=> 2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2 . Bifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; menaquinone biosynthesis protein 855924 menD 9283865 menD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 menaquinone biosynthesis protein YP_003687720.1 854269 D 754252 CDS YP_003687721.1 297625958 9283866 856032..858602 1 NC_014215.1 UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A). The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 858602 uvrA1 9283866 uvrA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 excinuclease ABC subunit A YP_003687721.1 856032 D 754252 CDS YP_003687722.1 297625959 9284463 858773..859249 1 NC_014215.1 hypothetical protein 859249 9284463 PFREUD_07510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687722.1 858773 D 754252 CDS YP_003687723.1 297625960 9282425 complement(859365..860633) 1 NC_014215.1 Chorismate <=> Isochorismate; isochorismate synthetase 860633 menF 9282425 menF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 isochorismate synthetase YP_003687723.1 859365 R 754252 CDS YP_003687724.1 297625961 9283869 complement(860699..861931) 1 NC_014215.1 ATP + 2-Succinylbenzoate + CoA <=> AMP + Pyrophosphate + 2-Succinylbenzoyl-CoA - Cofactor biosynthesis; menaquinone biosynthesis; menaquinone from chorismate: step 4/7.; O-succinylbenzoic acid--CoA ligase 861931 menE2 9283869 menE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 O-succinylbenzoic acid--CoA ligase YP_003687724.1 860699 R 754252 CDS YP_003687725.1 297625962 9283868 complement(862004..863008) 1 NC_014215.1 2-Succinylbenzoyl-CoA <=> 1,4-dihydroxy-2-naphthoate + CoA . Cofactor biosynthesis; menaquinone biosynthesis; menaquinone from chorismate: step 5/7; naphthoate synthase 863008 menB 9283868 menB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 naphthoate synthase YP_003687725.1 862004 R 754252 CDS YP_003687726.1 297625963 9283864 complement(863171..864526) 1 NC_014215.1 Nicotinate D-ribonucleotide + Pyrophosphate <=> Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate; Nicotinate phosphoribosyltransferase 864526 pncB 9283864 pncB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Nicotinate phosphoribosyltransferase YP_003687726.1 863171 R 754252 CDS YP_003687727.1 297625964 9284086 864635..864946 1 NC_014215.1 ATP-dependent Clp protease adaptor protein clpS 864946 clpS 9284086 clpS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease adaptor protein clpS YP_003687727.1 864635 D 754252 CDS YP_003687728.1 297625965 9283425 864946..865551 1 NC_014215.1 hypothetical protein 865551 9283425 PFREUD_07570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687728.1 864946 D 754252 CDS YP_003687729.1 297625966 9282426 865639..866457 1 NC_014215.1 L-glutamate <=> D-glutamate; glutamate racemase 866457 murI 9282426 murI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate racemase YP_003687729.1 865639 D 754252 CDS YP_003687730.1 297625967 9283923 866611..867372 1 NC_014215.1 3 prime exoribonuclease family, domain 1. This family includes 3 prime-5 prime exoribonucleases. ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA.; tRNA nucleotidyltransferase 867372 rph 9283923 rph Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA nucleotidyltransferase YP_003687730.1 866611 D 754252 CDS YP_003687731.1 297625968 9284195 867369..868175 1 NC_014215.1 HAM1, NTPase/HAM1 868175 9284195 PFREUD_07600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 HAM1, NTPase/HAM1 YP_003687731.1 867369 D 754252 CDS YP_003687732.1 297625969 9282427 868177..868989 1 NC_014215.1 Provides the sole de novo source of dTMP for DNA biosynthesis - dUMP + 5,10-methylenetetrahydrofolate <=> dihydrofolate + dTMP; Thymidylate synthase 868989 thyA 9282427 thyA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Thymidylate synthase YP_003687732.1 868177 D 754252 CDS YP_003687733.1 297625970 9284340 869077..869706 1 NC_014215.1 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH. tetrahydrofolate biosynthesis; tetrahydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 3/3.; dihydrofolate reductase 869706 folA 9284340 folA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrofolate reductase YP_003687733.1 869077 D 754252 CDS YP_003687734.1 297625971 9283566 869710..871161 1 NC_014215.1 deoxynucleoside triphosphate + DNA <=> Pyrophosphate + DNA; DNA polymerase IV 871161 dinB 9283566 dinB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase IV YP_003687734.1 869710 D 754252 CDS YP_003687735.1 297625972 9283498 complement(871365..872378) 1 NC_014215.1 kinase 872378 argK 9283498 argK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 kinase YP_003687735.1 871365 R 754252 CDS YP_003687736.1 297625973 9283335 complement(872371..874557) 1 NC_014215.1 methylmalonyl-CoA mutase catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Induced by heat and acid stresses.; methylmalonyl-CoA mutase subunit alpha 874557 mutB 9283335 mutB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylmalonyl-CoA mutase subunit alpha YP_003687736.1 872371 R 754252 CDS YP_003687737.1 297625974 9283926 complement(874554..876470) 1 NC_014215.1 methylmalonyl-CoA mutase catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. Induced by heat and acid stresses.; methylmalonyl-CoA mutase subunit beta 876470 mutA 9283926 mutA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylmalonyl-CoA mutase subunit beta YP_003687737.1 874554 R 754252 CDS YP_003687738.1 297625975 9283925 complement(876727..876888) 1 NC_014215.1 hypothetical protein 876888 9283925 PFREUD_07670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687738.1 876727 R 754252 CDS YP_003687739.1 297625976 9282428 877302..878075 1 NC_014215.1 cobalt-precorrin 2 + S-adenosyl-L-methionine <=> cobalt-precorrin 3 + S-adenosyl-L-homocysteine; CbiL Precorrin-2 C20-methyltransferase 878075 cbiL 9282428 cbiL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CbiL Precorrin-2 C20-methyltransferase YP_003687739.1 877302 D 754252 CDS YP_003687740.1 297625977 9283402 878105..879064 1 NC_014215.1 # S-adenosyl-L-methionine + Precorrin 4 <=> S-adenosyl-L-homocysteine + Precorrin 5; CbiF Precorrin-4 C11-methyltransferase 879064 cbiF 9283402 cbiF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CbiF Precorrin-4 C11-methyltransferase YP_003687740.1 878105 D 754252 CDS YP_003687741.1 297625978 9283400 879061..881721 1 NC_014215.1 S-adenosyl-L-methionine + Precorrin 3B <=> S-adenosyl-L-homocysteine + Precorrin 4 / cobalt-precorrin 3 + S-adenosyl-L-methionine <=> cobalt-precorrin 4 + S-adenosyl-L-homocysteine; precorrin methylase 881721 cobJ/cbiE/cbiG/cbiH 9283400 cobJ/cbiE/cbiG/cbiH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 precorrin methylase YP_003687741.1 879061 D 754252 CDS YP_003687742.1 297625979 9283435 881714..882955 1 NC_014215.1 cobalt fixation on precorrin 2; CysG/CbiX 882955 cysG/cbiX 9283435 cysG/cbiX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CysG/CbiX YP_003687742.1 881714 D 754252 CDS YP_003687743.1 297625980 9283462 complement(882987..884279) 1 NC_014215.1 cobalt-precorrin-6A synthase [deacetylating] CbiD 884279 cbiD 9283462 cbiD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt-precorrin-6A synthase [deacetylating] CbiD YP_003687743.1 882987 R 754252 CDS YP_003687744.1 297625981 9283399 complement(884276..884929) 1 NC_014215.1 * Precorrin 8X <=> Hydrogenobyrinate; Precorrin 8X methylmutase CbiC 884929 cbiC 9283399 cbiC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Precorrin 8X methylmutase CbiC YP_003687744.1 884276 R 754252 CDS YP_003687746.1 297625983 9282429 complement(885026..885616) 1 NC_014215.1 Precorrin 8 decarboxylase CbiT 885616 cbiT 9282429 cbiT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Precorrin 8 decarboxylase CbiT YP_003687746.1 885026 R 754252 CDS YP_003687747.1 297625984 9283411 complement(885689..886456) 1 NC_014215.1 # Precorrin 6Y + NADP+ <=> Precorrin 6X + NADPH + H+; precorrin-6x reductase 886456 CbiJ 9283411 CbiJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 precorrin-6x reductase YP_003687747.1 885689 R 754252 CDS YP_003687748.1 297625985 9283401 complement(886437..887129) 1 NC_014215.1 L-Ribulose 5-phosphate <=> D-Xylulose 5-phosphate; L-ribulose-5-phosphate 4-epimerase AraD 887129 araD 9283401 araD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-ribulose-5-phosphate 4-epimerase AraD YP_003687748.1 886437 R 754252 CDS YP_003687749.1 297625986 9282430 complement(887422..887910) 1 NC_014215.1 thioredoxin reductase 887910 bcp 9282430 bcp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin reductase YP_003687749.1 887422 R 754252 CDS YP_003687750.1 297625987 9283375 888084..888383 1 NC_014215.1 hypothetical protein 888383 9283375 PFREUD_07800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687750.1 888084 D 754252 CDS YP_003687751.1 297625988 9282431 888410..888859 1 NC_014215.1 molecular chaperone GroES 888859 groS2 9282431 groS2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone GroES YP_003687751.1 888410 D 754252 CDS YP_003687752.1 297625989 9282432 complement(889121..889894) 1 NC_014215.1 adenosyl cobyrinate a,c diamide + 4 L-glutamine + 4 ATP + 4 H2O <=> adenosyl cobyrinate hexaamide + 4 L-glutamate + 4 Orthophosphate + 4 ADP; glutamine amidotransferase 889894 cobB/cobQ 9282432 cobB/cobQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine amidotransferase YP_003687752.1 889121 R 754252 CDS YP_003687753.1 297625990 9283434 complement(889888..891201) 1 NC_014215.1 ATP + Long-subunit carboxylate + CoA <=> AMP + Pyrophosphate + acyl-CoA; UDP-N-acetylmuramyl tripeptide synthase 891201 9283434 PFREUD_07840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylmuramyl tripeptide synthase YP_003687753.1 889888 R 754252 CDS YP_003687754.1 297625991 9282433 complement(891314..892159) 1 NC_014215.1 protein tyrosine phosphate + H2O <=> protein tyrosine + Orthophosphate; protein-tyrosine-phosphatase 892159 9282433 PFREUD_07850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein-tyrosine-phosphatase YP_003687754.1 891314 R 754252 CDS YP_003687755.1 297625992 9282434 complement(892229..894562) 1 NC_014215.1 UvrA, Excinuclease ATPase subunit 894562 uvrA2 9282434 uvrA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UvrA, Excinuclease ATPase subunit YP_003687755.1 892229 R 754252 CDS YP_003687756.1 297625993 9284464 894637..895143 1 NC_014215.1 metal dependent phosphohydrolase 895143 9284464 PFREUD_07870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal dependent phosphohydrolase YP_003687756.1 894637 D 754252 CDS YP_003687757.1 297625994 9282436 complement(895881..896552) 1 NC_014215.1 oligoribonuclease 896552 orn 9282436 orn Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 oligoribonuclease YP_003687757.1 895881 R 754252 CDS YP_003687758.1 297625995 9283987 complement(896573..897838) 1 NC_014215.1 hypothetical protein 897838 9283987 PFREUD_07900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687758.1 896573 R 754252 CDS YP_003687759.1 297625996 9282438 898078..899580 1 NC_014215.1 hypothetical protein 899580 9282438 PFREUD_07920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687759.1 898078 D 754252 CDS YP_003687760.1 297625997 9282439 899650..901512 1 NC_014215.1 ABC transporter 901512 9282439 PFREUD_07930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687760.1 899650 D 754252 CDS YP_003687761.1 297625998 9282440 901509..903152 1 NC_014215.1 ABC transporter 903152 PPA1638 9282440 PPA1638 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003687761.1 901509 D 754252 CDS YP_003687762.1 297625999 9284102 903149..903811 1 NC_014215.1 hypothetical protein 903811 9284102 PFREUD_07950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687762.1 903149 D 754252 CDS YP_003687763.1 297626000 9282441 904028..904528 1 NC_014215.1 single-stranded DNA-binding protein 904528 ssb2 9282441 ssb2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 single-stranded DNA-binding protein YP_003687763.1 904028 D 754252 CDS YP_003687764.1 297626001 9284302 904724..906412 1 NC_014215.1 ABC transporter ATP-binding protein 906412 9284302 PFREUD_07970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687764.1 904724 D 754252 CDS YP_003687765.1 297626002 9282442 906584..907579 1 NC_014215.1 ATP + glycerone <=> ADP + glycerone phosphate; DhaK PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit 907579 dhaK 9282442 dhaK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DhaK PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit YP_003687765.1 906584 D 754252 CDS YP_003687766.1 297626003 9283494 907579..908208 1 NC_014215.1 Complexation with ADP increases the thermal unfolding temperature from 40 to 65 degrees Celsius ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from dhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of dhaR. DhaL-ATP is inactive.; PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL 908208 dhaL 9283494 dhaL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL YP_003687766.1 907579 D 754252 CDS YP_003687767.1 297626004 9283496 908221..909741 1 NC_014215.1 phosphoenolpyruvate-protein phosphoryltransferase PptE 909741 pptE 9283496 pptE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoenolpyruvate-protein phosphoryltransferase PptE YP_003687767.1 908221 D 754252 CDS YP_003687768.1 297626005 9284112 complement(909728..911098) 1 NC_014215.1 UDP-glucose + alpha-D-Galactose 1-phosphate <=> D-glucose 1-phosphate + UDP-D-galactose; galactose-1-phosphate uridylyltransferase 911098 galT 9284112 galT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 galactose-1-phosphate uridylyltransferase YP_003687768.1 909728 R 754252 CDS YP_003687770.1 297626007 9282443 911155..913191 1 NC_014215.1 Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides. Hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1 is Pro, or both P1 and P1 are Gly.; peptidyl-dipeptidase 913191 dcp 9282443 dcp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidyl-dipeptidase YP_003687770.1 911155 D 754252 CDS YP_003687771.1 297626008 9283482 complement(913312..916140) 1 NC_014215.1 oxidoreductase 916140 9283482 PFREUD_08040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 oxidoreductase YP_003687771.1 913312 R 754252 CDS YP_003687772.1 297626009 9282444 complement(916146..916604) 1 NC_014215.1 pfam01047, MarR, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system.; MarR family transcriptional regulator 916604 marR1 9282444 marR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MarR family transcriptional regulator YP_003687772.1 916146 R 754252 CDS YP_003687773.1 297626010 9283859 916781..918670 1 NC_014215.1 ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Pyrophosphate / ATP + Long-subunit carboxylate + CoA <=> AMP + Pyrophosphate + acyl-CoA; long-subunit fatty-acid CoA ligase 918670 9283859 PFREUD_08060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 long-subunit fatty-acid CoA ligase YP_003687773.1 916781 D 754252 CDS YP_003687774.1 297626011 9282445 918676..919557 1 NC_014215.1 hypothetical protein 919557 pf2652 9282445 pf2652 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687774.1 918676 D 754252 CDS YP_003687775.1 297626012 9284042 complement(919704..920525) 1 NC_014215.1 ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 920525 thiD2 9284042 thiD2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase YP_003687775.1 919704 R 754252 CDS YP_003687776.1 297626013 9284330 complement(920655..922112) 1 NC_014215.1 6-phospho-D-gluconate + NADP+ <=> D-Ribulose 5-phosphate + CO2 + NADPH + H+; 6-phosphogluconate dehydrogenase 922112 gnd2 9284330 gnd2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 6-phosphogluconate dehydrogenase YP_003687776.1 920655 R 754252 CDS YP_003687777.1 297626014 9283648 complement(922325..924928) 1 NC_014215.1 aminopeptidase with broad substrate specificity. Preference for leucine, cleaves also next to Arg and lysine. Release of an N-terminal aa, Xaa-|-Yaa-. Xaa is preferably Ala. Xaa-Pro may be released. peptidase M1 family. Monomer. Binds 1 zinc ion per subunit, Cytoplasmic.; aminopeptidase 924928 pepN 9283648 pepN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminopeptidase YP_003687777.1 922325 R 754252 CDS YP_003687778.1 297626015 9284029 925271..925885 1 NC_014215.1 DSBA-like thioredoxin 925885 9284029 PFREUD_08110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DSBA-like thioredoxin YP_003687778.1 925271 D 754252 CDS YP_003687779.1 297626016 9282446 926109..926903 1 NC_014215.1 hypothetical protein 926903 9282446 PFREUD_08120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687779.1 926109 D 754252 CDS YP_003687780.1 297626017 9282447 926980..929274 1 NC_014215.1 NAD+ + DNA <=> AMP + Nicotinamide D-ribonucleotide + DNA; DNA ligase 929274 ligA 9282447 ligA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA ligase YP_003687780.1 926980 D 754252 CDS YP_003687781.1 297626018 9283826 complement(929342..929908) 1 NC_014215.1 TetR family transcriptional regulator 929908 tetR5 9283826 tetR5 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003687781.1 929342 R 754252 CDS YP_003687782.1 297626019 9284324 930002..930859 1 NC_014215.1 hypothetical protein 930859 9284324 PFREUD_08150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687782.1 930002 D 754252 CDS YP_003687783.1 297626020 9284348 complement(931909..933480) 1 NC_014215.1 hypothetical protein 933480 9284348 PFREUD_08160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687783.1 931909 R 754252 CDS YP_003687784.1 297626021 9282449 933656..933904 1 NC_014215.1 hypothetical protein 933904 9282449 PFREUD_08170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687784.1 933656 D 754252 CDS YP_003687785.1 297626022 9282450 934004..934330 1 NC_014215.1 Belongs to the small multidrug resistance (SMR) protein family; Small multidrug resistance protein 934330 sugE 9282450 sugE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Small multidrug resistance protein YP_003687785.1 934004 D 754252 CDS YP_003687786.1 297626023 9282452 935066..936649 1 NC_014215.1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation; Trigger factor (TF) 936649 tig 9282452 tig Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Trigger factor (TF) YP_003687786.1 935066 D 754252 CDS YP_003687787.1 297626024 9284341 936874..938067 1 NC_014215.1 hypothetical protein 938067 9284341 PFREUD_08220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687787.1 936874 D 754252 CDS YP_003687788.1 297626025 9282453 938258..939532 1 NC_014215.1 hypothetical protein 939532 9282453 PFREUD_08230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687788.1 938258 D 754252 CDS YP_003687789.1 297626026 9282454 939619..940254 1 NC_014215.1 ATP-dependent Clp protease proteolytic subunit 1 940254 clpP1 9282454 clpP1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease proteolytic subunit 1 YP_003687789.1 939619 D 754252 CDS YP_003687790.1 297626027 9283423 940278..940967 1 NC_014215.1 ATP-dependent Clp protease proteolytic subunit 2 940967 clpP2 9283423 clpP2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease proteolytic subunit 2 YP_003687790.1 940278 D 754252 CDS YP_003687791.1 297626028 9283424 941089..942366 1 NC_014215.1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP; ATP-dependent Clp protease ATP-binding subunit ClpX 942366 clpX 9283424 clpX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease ATP-binding subunit ClpX YP_003687791.1 941089 D 754252 CDS YP_003687792.1 297626029 9283426 complement(942478..942792) 1 NC_014215.1 hypothetical protein 942792 9283426 PFREUD_08270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687792.1 942478 R 754252 CDS YP_003687793.1 297626030 9282455 942911..944353 1 NC_014215.1 O-phospho-L-homoserine + H2O <=> L-Threonine + Orthophosphate / O-phospho-4-hydroxy-L-threonine + H2O <=> 4-Hydroxy-L-threonine + Orthophosphate; threonine synthase 944353 thrC 9282455 thrC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 threonine synthase YP_003687793.1 942911 D 754252 CDS YP_003687794.1 297626031 9284338 944432..945553 1 NC_014215.1 ATP + D-Fructose 6-phosphate <=> ADP + D-Fructose 1,6-bisphosphate; 6-phosphofructokinase 945553 pfkA 9284338 pfkA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 6-phosphofructokinase YP_003687794.1 944432 D 754252 CDS YP_003687795.1 297626032 9284054 945638..946387 1 NC_014215.1 haloacid dehalogenase 946387 9284054 PFREUD_08300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 haloacid dehalogenase YP_003687795.1 945638 D 754252 CDS YP_003687796.1 297626033 9282456 complement(946495..949113) 1 NC_014215.1 valyl-tRNA synthetase 949113 valS 9282456 valS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 valyl-tRNA synthetase YP_003687796.1 946495 R 754252 CDS YP_003687797.1 297626034 9284470 complement(949212..950006) 1 NC_014215.1 hypothetical protein 950006 9284470 PFREUD_08320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687797.1 949212 R 754252 CDS YP_003687798.1 297626035 9282457 complement(950270..951064) 1 NC_014215.1 protein-disulfide isomerase; DSBA oxidoreductase 951064 dsbG 9282457 dsbG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DSBA oxidoreductase YP_003687798.1 950270 R 754252 CDS YP_003687799.1 297626036 9283524 complement(951100..951678) 1 NC_014215.1 hypothetical protein 951678 9283524 PFREUD_08340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687799.1 951100 R 754252 CDS YP_003687800.1 297626037 9282458 951826..953331 1 NC_014215.1 ATP + Tetrahydrofolate + L-glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2); folylpolyglutamate synthase 953331 folC 9282458 folC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 folylpolyglutamate synthase YP_003687800.1 951826 D 754252 CDS YP_003687801.1 297626038 9283568 953442..953918 1 NC_014215.1 nucleoside-diphosphate kinase 953918 ndk 9283568 ndk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nucleoside-diphosphate kinase YP_003687801.1 953442 D 754252 CDS YP_003687802.1 297626039 9283945 953915..955255 1 NC_014215.1 hypothetical protein 955255 9283945 PFREUD_08370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687802.1 953915 D 754252 CDS YP_003687803.1 297626040 9282459 955332..957275 1 NC_014215.1 Fe-S oxidoreductase 957275 9282459 PFREUD_08380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fe-S oxidoreductase YP_003687803.1 955332 D 754252 CDS YP_003687804.1 297626041 9282460 complement(957339..958439) 1 NC_014215.1 ionic transporter integral membrane protein 958439 chaA 9282460 chaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ionic transporter integral membrane protein YP_003687804.1 957339 R 754252 CDS YP_003687805.1 297626042 9283414 complement(958436..959692) 1 NC_014215.1 No signal peptide (signalP), membrane protein (TM HMM); hypothetical protein 959692 9283414 PFREUD_08400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687805.1 958436 R 754252 CDS YP_003687806.1 297626043 9282461 959907..960362 1 NC_014215.1 MarR family transcriptional regulator 960362 9282461 PFREUD_08410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MarR family transcriptional regulator YP_003687806.1 959907 D 754252 CDS YP_003687807.1 297626044 9282462 960426..961178 1 NC_014215.1 hypothetical protein 961178 9282462 PFREUD_08420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687807.1 960426 D 754252 CDS YP_003687809.1 297626046 9282464 961432..964218 1 NC_014215.1 ribonuclease, Rne/Rng family 964218 9282464 PFREUD_08440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease, Rne/Rng family YP_003687809.1 961432 D 754252 CDS YP_003687810.1 297626047 9282465 964454..964762 1 NC_014215.1 50S ribosomal protein L21 964762 rplU 9282465 rplU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L21 YP_003687810.1 964454 D 754252 CDS YP_003687811.1 297626048 9284217 964776..965039 1 NC_014215.1 50S ribosomal protein L27 965039 rpmA 9284217 rpmA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L27 YP_003687811.1 964776 D 754252 CDS YP_003687813.1 297626050 9282466 965188..966789 1 NC_014215.1 GTPase 966789 obg 9282466 obg Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTPase YP_003687813.1 965188 D 754252 CDS YP_003687814.1 297626051 9283980 966779..967951 1 NC_014215.1 ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate; glutamate 5-kinase 967951 proB 9283980 proB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate 5-kinase YP_003687814.1 966779 D 754252 CDS YP_003687815.1 297626052 9284119 967984..968610 1 NC_014215.1 hypothetical protein 968610 9284119 PFREUD_08500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687815.1 967984 D 754252 CDS YP_003687816.1 297626053 9282467 968663..969904 1 NC_014215.1 Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.; gamma-glutamyl phosphate reductase 969904 proA 9282467 proA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 gamma-glutamyl phosphate reductase YP_003687816.1 968663 D 754252 CDS YP_003687818.1 297626055 9282468 969978..970748 1 NC_014215.1 # ATP + Nicotinamide D-ribonucleotide <=> Pyrophosphate + NAD+; nicotinate-nucleotide adenylyltransferase 970748 nadD 9282468 nadD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nicotinate-nucleotide adenylyltransferase YP_003687818.1 969978 D 754252 CDS YP_003687819.1 297626056 9283938 970745..971128 1 NC_014215.1 hypothetical protein 971128 9283938 PFREUD_08540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687819.1 970745 D 754252 CDS YP_003687820.1 297626057 9282469 971128..971736 1 NC_014215.1 2-phospho-D-glycerate <=> 3-phospho-D-glycerate and 3-phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate; phosphoglycerate mutase 971736 gmpB 9282469 gmpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate mutase YP_003687820.1 971128 D 754252 CDS YP_003687821.1 297626058 9283646 971796..972233 1 NC_014215.1 hypothetical protein 972233 9283646 PFREUD_08560 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687821.1 971796 D 754252 CDS YP_003687822.1 297626059 9282470 972348..973268 1 NC_014215.1 NAD-dependent epimerase/dehydratase 973268 9282470 PFREUD_08570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NAD-dependent epimerase/dehydratase YP_003687822.1 972348 D 754252 CDS YP_003687823.1 297626060 9282472 complement(973571..974311) 1 NC_014215.1 hypothetical protein 974311 9282472 PFREUD_08590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687823.1 973571 R 754252 CDS YP_003687824.1 297626061 9282473 974529..975539 1 NC_014215.1 hypothetical protein 975539 9282473 PFREUD_08600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687824.1 974529 D 754252 CDS YP_003687825.1 297626062 9282474 975856..978384 1 NC_014215.1 leucyl-tRNA synthetase 978384 leuS 9282474 leuS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 leucyl-tRNA synthetase YP_003687825.1 975856 D 754252 CDS YP_003687826.1 297626063 9283823 978441..979733 1 NC_014215.1 (S)-dihydroorotate + H2O <=> N-carbamoyl-L-aspartate; dihydroorotase 979733 pyrC 9283823 pyrC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroorotase YP_003687826.1 978441 D 754252 CDS YP_003687827.1 297626064 9284153 979751..981505 1 NC_014215.1 The protein has been identified by proteomics as a 70 kDa / PI 5.9 protein induced by various stresses including starvation; malate dehydrogenase 981505 PPA0888 9284153 PPA0888 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 malate dehydrogenase YP_003687827.1 979751 D 754252 CDS YP_003687828.1 297626065 9284096 981624..982601 1 NC_014215.1 hypothetical protein 982601 9284096 PFREUD_08640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687828.1 981624 D 754252 CDS YP_003687829.1 297626066 9282475 982720..985041 1 NC_014215.1 ComE operon protein 3 985041 comEC 9282475 comEC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ComE operon protein 3 YP_003687829.1 982720 D 754252 CDS YP_003687830.1 297626067 9283442 985097..986122 1 NC_014215.1 DNA polymerase III subunit delta 986122 holA 9283442 holA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase III subunit delta YP_003687830.1 985097 D 754252 CDS YP_003687831.1 297626068 9283711 complement(986136..986798) 1 NC_014215.1 hypothetical protein 986798 9283711 PFREUD_08670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687831.1 986136 R 754252 CDS YP_003687832.1 297626069 9282476 complement(986932..987192) 1 NC_014215.1 Binds directly to 16S ribosomal RNA; 30S ribosomal protein S20 987192 rpsT 9282476 rpsT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S20 YP_003687832.1 986932 R 754252 CDS YP_003687833.1 297626070 9284253 987447..988067 1 NC_014215.1 hypothetical protein 988067 9284253 PFREUD_08690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687833.1 987447 D 754252 CDS YP_003687834.1 297626071 9282477 988006..988134 1 NC_014215.1 hypothetical protein 988134 9282477 PFREUD_08700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687834.1 988006 D 754252 CDS YP_003687835.1 297626072 9282478 988368..990197 1 NC_014215.1 GTP-binding protein LepA 990197 lepA 9282478 lepA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP-binding protein LepA YP_003687835.1 988368 D 754252 CDS YP_003687836.1 297626073 9283816 990200..991399 1 NC_014215.1 Coproporphyrinogen III + Oxygen <=> Protoporphyrinogen IX + 2 CO2 + 2 H2O; Coproporphyrinogen oxidase / Oxygen-independent coproporphyrinogen III oxidase 991399 hemM 9283816 hemM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Coproporphyrinogen oxidase / Oxygen-independent coproporphyrinogen III oxidase YP_003687836.1 990200 D 754252 CDS YP_003687837.1 297626074 9283693 991494..992375 1 NC_014215.1 hypothetical protein 992375 9283693 PFREUD_08730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687837.1 991494 D 754252 CDS YP_003687838.1 297626075 9282479 992447..993229 1 NC_014215.1 inositol-phosphate phosphatase 993229 9282479 PFREUD_08740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inositol-phosphate phosphatase YP_003687838.1 992447 D 754252 CDS YP_003687839.1 297626076 9282480 993487..994497 1 NC_014215.1 Heat-inducible transcription repressor hrcA 994497 hrcA 9282480 hrcA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Heat-inducible transcription repressor hrcA YP_003687839.1 993487 D 754252 CDS YP_003687840.1 297626077 9283713 994510..995718 1 NC_014215.1 3 pralogs of dnaj exist in P.freudenreichii, comprised in the 3 operons dnaK1, dnaK2 and hrcA.; molecular chaperone DnaJ 995718 dnaJ3 9283713 dnaJ3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone DnaJ YP_003687840.1 994510 D 754252 CDS YP_003687841.1 297626078 9283515 995715..996464 1 NC_014215.1 hypothetical protein 996464 9283515 PFREUD_08770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687841.1 995715 D 754252 CDS YP_003687842.1 297626079 9282481 complement(996453..997760) 1 NC_014215.1 metallophosphoesterase 997760 9282481 PFREUD_08780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metallophosphoesterase YP_003687842.1 996453 R 754252 CDS YP_003687843.1 297626080 9282482 997901..999169 1 NC_014215.1 queuine tRNA-ribosyltransferase 999169 9282482 PFREUD_08790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 queuine tRNA-ribosyltransferase YP_003687843.1 997901 D 754252 CDS YP_003687844.1 297626081 9282483 999282..999833 1 NC_014215.1 hypothetical protein 999833 9282483 PFREUD_08800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687844.1 999282 D 754252 CDS YP_003687845.1 297626082 9282484 999915..1000973 1 NC_014215.1 Specifically catalyzes the removal of N-terminal proline residues from peptides, Release of N-terminal proline from a peptide, Belongs to the peptidase S33 family, cytoplasmic; proline iminopeptidase 1000973 pip2 9282484 pip2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 proline iminopeptidase YP_003687845.1 999915 D 754252 CDS YP_003687846.1 297626083 9284076 1001029..1001520 1 NC_014215.1 hypothetical protein 1001520 9284076 PFREUD_08820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687846.1 1001029 D 754252 CDS YP_003687847.1 297626084 9282485 1001614..1003071 1 NC_014215.1 transporter, MFS superfamily protein 1003071 9282485 PFREUD_08830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transporter, MFS superfamily protein YP_003687847.1 1001614 D 754252 CDS YP_003687848.1 297626085 9282486 1003203..1004210 1 NC_014215.1 phosphate starvation-inducible protein PhoH-like protein 1004210 phoH 9282486 phoH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphate starvation-inducible protein PhoH-like protein YP_003687848.1 1003203 D 754252 CDS YP_003687849.1 297626086 9284070 1004257..1004715 1 NC_014215.1 hypothetical protein 1004715 9284070 PFREUD_08850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687849.1 1004257 D 754252 CDS YP_003687850.1 297626087 9282487 1004869..1006173 1 NC_014215.1 hypothetical protein 1006173 9282487 PFREUD_08860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687850.1 1004869 D 754252 CDS YP_003687851.1 297626088 9282488 1006160..1007110 1 NC_014215.1 Binds both GDP and GTP, has an intrinsic GTPase activity and is essential for cell growth; GTP-binding protein 1007110 era 9282488 era Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP-binding protein YP_003687851.1 1006160 D 754252 CDS YP_003687852.1 297626089 9283537 1007160..1007627 1 NC_014215.1 hypothetical protein 1007627 9283537 PFREUD_08880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687852.1 1007160 D 754252 CDS YP_003687853.1 297626090 9282489 1007624..1007767 1 NC_014215.1 hypothetical protein 1007767 9282489 PFREUD_08890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687853.1 1007624 D 754252 CDS YP_003687854.1 297626091 9282490 1007878..1008012 1 NC_014215.1 hypothetical protein 1008012 9282490 PFREUD_08900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687854.1 1007878 D 754252 CDS YP_003687855.1 297626092 9282491 complement(1008141..1009637) 1 NC_014215.1 metal-dependent hydrolase 1009637 9282491 PFREUD_08910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal-dependent hydrolase YP_003687855.1 1008141 R 754252 CDS YP_003687856.1 297626093 9282492 1009878..1011644 1 NC_014215.1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. (2S)-2-Isopropylmalate + CoA <=> acetyl-CoA + 3-methyl-2-oxobutanoic acid + H2O; 2-isopropylmalate synthase 1011644 leuA1 9282492 leuA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-isopropylmalate synthase YP_003687856.1 1009878 D 754252 CDS YP_003687857.1 297626094 9283818 complement(1011759..1012121) 1 NC_014215.1 hypothetical protein 1012121 9283818 PFREUD_08930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687857.1 1011759 R 754252 CDS YP_003687858.1 297626095 9282493 complement(1012182..1012982) 1 NC_014215.1 Generates UDP pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. trans,trans,cis-Geranylgeranyl diphosphate + 7 Isopentenyl diphosphate <=> di-trans,poly-cis-UDP diphosphate + 7 Pyrophosphate; UDP diphosphate synthase 1012982 uppS2 9282493 uppS2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP diphosphate synthase YP_003687858.1 1012182 R 754252 CDS YP_003687859.1 297626096 9284460 1013055..1013798 1 NC_014215.1 Involved in DNA repair and recF pathway recombination; DNA repair protein RecO 1013798 recO 9284460 recO Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA repair protein RecO YP_003687859.1 1013055 D 754252 CDS YP_003687860.1 297626097 9284168 1013962..1015155 1 NC_014215.1 Positive regulatory protein of pdu and cob operons.; transcriptional regulator 1015155 pocR 9284168 pocR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003687860.1 1013962 D 754252 CDS YP_003687861.1 297626098 9284090 1015339..1016469 1 NC_014215.1 Fe-dependent alcohol dehydrogenase 1016469 adh1 9284090 adh1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fe-dependent alcohol dehydrogenase YP_003687861.1 1015339 D 754252 CDS YP_003687862.1 297626099 9283300 complement(1016522..1016947) 1 NC_014215.1 glycerol metabolism; propanediol utilization protein PduV 1016947 pduV 9283300 pduV Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduV YP_003687862.1 1016522 R 754252 CDS YP_003687863.1 297626100 9284020 complement(1016944..1017285) 1 NC_014215.1 cobalamin-dependent degradation of ethanolamine; propanediol utilization protein PduU 1017285 pdU 9284020 pdU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduU YP_003687863.1 1016944 R 754252 CDS YP_003687864.1 297626101 9284007 1017612..1017896 1 NC_014215.1 glycerol metabolism; propanediol utilization protein PduA 1017896 pduA 9284007 pduA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduA YP_003687864.1 1017612 D 754252 CDS YP_003687865.1 297626102 9284009 1017911..1018720 1 NC_014215.1 glycerol degradation; propanediol utilization protein PduB 1018720 pduB 9284009 pduB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduB YP_003687865.1 1017911 D 754252 CDS YP_003687866.1 297626103 9284010 1018735..1020396 1 NC_014215.1 glycerol dehydratase large subunit 1020396 pduC 9284010 pduC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerol dehydratase large subunit YP_003687866.1 1018735 D 754252 CDS YP_003687867.1 297626104 9284011 1020401..1021090 1 NC_014215.1 propanediol utilization protein PduD 1021090 pduD 9284011 pduD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduD YP_003687867.1 1020401 D 754252 CDS YP_003687868.1 297626105 9284012 1021099..1021632 1 NC_014215.1 glycerol degradation; propanediol utilization protein PduE 1021632 pduE 9284012 pduE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduE YP_003687868.1 1021099 D 754252 CDS YP_003687869.1 297626106 9284013 1021668..1023482 1 NC_014215.1 glycerol degradation; propanediol utilization diol dehydratase reactivation protein PduG 1023482 pduG 9284013 pduG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization diol dehydratase reactivation protein PduG YP_003687869.1 1021668 D 754252 CDS YP_003687870.1 297626107 9284014 1023479..1023823 1 NC_014215.1 glycerol metabolism; glycerol dehydratase reactivation factor DhaG 1023823 DhaG 9284014 DhaG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerol dehydratase reactivation factor DhaG YP_003687870.1 1023479 D 754252 CDS YP_003687871.1 297626108 9283493 1023840..1024457 1 NC_014215.1 propanediol utilization protein PduK 1024457 pduK 9283493 pduK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduK YP_003687871.1 1023840 D 754252 CDS YP_003687872.1 297626109 9284016 1024502..1024780 1 NC_014215.1 propanediol utilization protein PduJ 1024780 pduJ 9284016 pduJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduJ YP_003687872.1 1024502 D 754252 CDS YP_003687873.1 297626110 9284015 1024927..1025784 1 NC_014215.1 Ethanolamine utilization protein EutJ 1025784 eutJ 9284015 eutJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ethanolamine utilization protein EutJ YP_003687873.1 1024927 D 754252 CDS YP_003687874.1 297626111 9283538 1025781..1026665 1 NC_014215.1 Ethanolamine utilization flavoprotein 1026665 pdu 9283538 pdu Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ethanolamine utilization flavoprotein YP_003687874.1 1025781 D 754252 CDS YP_003687875.1 297626112 9284008 1026667..1026939 1 NC_014215.1 glycerol metabolism; propanediol utilization protein PduN 1026939 pduN 9284008 pduN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduN YP_003687875.1 1026667 D 754252 CDS YP_003687876.1 297626113 9284017 1026942..1028027 1 NC_014215.1 glycerol metabolism; propanediol utilization protein PduO 1028027 pduO 9284017 pduO Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 propanediol utilization protein PduO YP_003687876.1 1026942 D 754252 CDS YP_003687877.1 297626114 9284018 1028024..1029433 1 NC_014215.1 glycerol metabolism; CoA-dependent propionaldehyde dehydrogenase PduP 1029433 pduP 9284018 pduP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CoA-dependent propionaldehyde dehydrogenase PduP YP_003687877.1 1028024 D 754252 CDS YP_003687878.1 297626115 9284019 complement(1029647..1030321) 1 NC_014215.1 phage integrase 1030321 int 9284019 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage integrase YP_003687878.1 1029647 R 754252 CDS YP_003687879.1 297626116 9283752 complement(1030574..1031086) 1 NC_014215.1 pfam01475, Ferric uptake regulator family. This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes.; Ferric-uptake regulator 1031086 fur 9283752 fur Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ferric-uptake regulator YP_003687879.1 1030574 R 754252 CDS YP_003687880.1 297626117 9283587 complement(1031052..1032059) 1 NC_014215.1 metal transport system ABC transporter permease 1032059 9283587 PFREUD_09160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal transport system ABC transporter permease YP_003687880.1 1031052 R 754252 CDS YP_003687881.1 297626118 9282494 complement(1032061..1032849) 1 NC_014215.1 Manganese/zinc transport system ABC transporter ATP-binding protein 1032849 mntB 9282494 mntB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Manganese/zinc transport system ABC transporter ATP-binding protein YP_003687881.1 1032061 R 754252 CDS YP_003687882.1 297626119 9283893 complement(1032944..1033891) 1 NC_014215.1 metal ABC transporter substrate-binding protein 1033891 9283893 PFREUD_09180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal ABC transporter substrate-binding protein YP_003687882.1 1032944 R 754252 CDS YP_003687883.1 297626120 9282495 1034124..1035512 1 NC_014215.1 glycyl-tRNA synthetase 1035512 glyQS 9282495 glyQS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycyl-tRNA synthetase YP_003687883.1 1034124 D 754252 CDS YP_003687884.1 297626121 9283644 complement(1035637..1036557) 1 NC_014215.1 Nicotinate D-ribonucleotide + Pyrophosphate + CO2 <=> Pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate; nicotinate-nucleotide pyrophosphorylase 1036557 nadC 9283644 nadC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nicotinate-nucleotide pyrophosphorylase YP_003687884.1 1035637 R 754252 CDS YP_003687885.1 297626122 9283937 complement(1036554..1038236) 1 NC_014215.1 Catalyzes the oxidation of L-aspartate to iminoaspartate. L-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2.; L-aspartate oxidase 1038236 nadB1 9283937 nadB1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-aspartate oxidase YP_003687885.1 1036554 R 754252 CDS YP_003687886.1 297626123 9283935 complement(1038233..1039213) 1 NC_014215.1 Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from iminoaspartate: step 1/1.; Quinolinate synthetase A 1039213 nadA 9283935 nadA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Quinolinate synthetase A YP_003687886.1 1038233 R 754252 CDS YP_003687887.1 297626124 9283934 1039280..1040032 1 NC_014215.1 NUDIX hydrolase 1040032 9283934 PFREUD_09230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003687887.1 1039280 D 754252 CDS YP_003687888.1 297626125 9282496 1040280..1041035 1 NC_014215.1 succinate + FAD <=> FADH2 + Fumarate and succinate + Acceptor <=> Fumarate + Reduced acceptor; succinate dehydrogenase subunit C 1041035 sdhC1 9282496 sdhC1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 succinate dehydrogenase subunit C YP_003687888.1 1040280 D 754252 CDS YP_003687889.1 297626126 9284269 1041032..1043116 1 NC_014215.1 # succinate + FAD <=> FADH2 + Fumarate , A flavoprotein (FAD) containing iron-sulfur centres. A component of EC 1.3.5.1 succinate dehydrogenase (ubiquinone); nitrate/sulfonate/bicarbonate ABC transporter substrate-binding protein 1043116 sdhA 9284269 sdhA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nitrate/sulfonate/bicarbonate ABC transporter substrate-binding protein YP_003687889.1 1041032 D 754252 CDS YP_003687890.1 297626127 9284265 1043113..1043871 1 NC_014215.1 # succinate + FAD <=> FADH2 + Fumarate; succinate dehydrogenase subunit B 1043871 sdhB 9284265 sdhB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 succinate dehydrogenase subunit B YP_003687890.1 1043113 D 754252 CDS YP_003687891.1 297626128 9284267 1043972..1045135 1 NC_014215.1 Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.; TIM-barrel enzyme, dihydrouridine synthase 1045135 dus 9284267 dus Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TIM-barrel enzyme, dihydrouridine synthase YP_003687891.1 1043972 D 754252 CDS YP_003687892.1 297626129 9283528 1045186..1046331 1 NC_014215.1 dGTP + H2O <=> deoxyguanosine + Triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 1046331 dgt 9283528 dgt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 deoxyguanosinetriphosphate triphosphohydrolase YP_003687892.1 1045186 D 754252 CDS YP_003687893.1 297626130 9283491 complement(1046348..1047106) 1 NC_014215.1 Signal peptide; ABC transporter permease 1047106 9283491 PFREUD_09290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687893.1 1046348 R 754252 CDS YP_003687894.1 297626131 9282497 complement(1047114..1047755) 1 NC_014215.1 hypothetical protein 1047755 9282497 PFREUD_09300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687894.1 1047114 R 754252 CDS YP_003687895.1 297626132 9282498 1048164..1049594 1 NC_014215.1 In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes pyruvate + CoA + NAD+ <=> acetyl-CoA + CO2 + NADH; dihydrolipoamide dehydrogenase 1049594 lpdB 9282498 lpdB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrolipoamide dehydrogenase YP_003687895.1 1048164 D 754252 CDS YP_003687896.1 297626133 9283834 complement(1049615..1050457) 1 NC_014215.1 Predicted hydrolases of the HAD superfamily; cof family hydrolase 1050457 cof 9283834 cof Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cof family hydrolase YP_003687896.1 1049615 R 754252 CDS YP_003687897.1 297626134 9283440 complement(1050465..1051391) 1 NC_014215.1 hypothetical protein 1051391 9283440 PFREUD_09330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687897.1 1050465 R 754252 CDS YP_003687898.1 297626135 9282499 1051636..1052688 1 NC_014215.1 ATPases MoxR family 1052688 moxR 9282499 moxR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPases MoxR family YP_003687898.1 1051636 D 754252 CDS YP_003687899.1 297626136 9283904 1052685..1053749 1 NC_014215.1 hypothetical protein 1053749 9283904 PFREUD_09350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687899.1 1052685 D 754252 CDS YP_003687900.1 297626137 9282500 1053749..1054723 1 NC_014215.1 ChlD, Mg-chelatase subunit ChlD 1054723 chlD 9282500 chlD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ChlD, Mg-chelatase subunit ChlD YP_003687900.1 1053749 D 754252 CDS YP_003687901.1 297626138 9283415 1054723..1055688 1 NC_014215.1 von Willebrand factor A 1055688 9283415 PFREUD_09370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 von Willebrand factor A YP_003687901.1 1054723 D 754252 CDS YP_003687902.1 297626139 9282501 1055685..1056437 1 NC_014215.1 alanine racemase 1056437 9282501 PFREUD_09380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alanine racemase YP_003687902.1 1055685 D 754252 CDS YP_003687903.1 297626140 9282502 complement(1056486..1058465) 1 NC_014215.1 peptidase S9C 1058465 pf435 9282502 pf435 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase S9C YP_003687903.1 1056486 R 754252 CDS YP_003687904.1 297626141 9284048 1058616..1059110 1 NC_014215.1 hypothetical protein 1059110 9284048 PFREUD_09400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687904.1 1058616 D 754252 CDS YP_003687905.1 297626142 9282503 complement(1059294..1060553) 1 NC_014215.1 acetyl-CoA + acyl-carrier protein <=> CoA + acetyl-ACP; 3-oxoacyl-ACP synthase 1060553 fabF 9282503 fabF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-oxoacyl-ACP synthase YP_003687905.1 1059294 R 754252 CDS YP_003687906.1 297626143 9283539 complement(1060605..1060856) 1 NC_014215.1 4 prime-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.; acyl carrier protein 1060856 acpP 9283539 acpP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acyl carrier protein YP_003687906.1 1060605 R 754252 CDS YP_003687907.1 297626144 9283292 complement(1060918..1061820) 1 NC_014215.1 acetyl-CoA + malonyl-ACP = acetoacyl-ACP + CoA + CO2; 3-oxoacyl-ACP synthase 1061820 fabH 9283292 fabH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-oxoacyl-ACP synthase YP_003687907.1 1060918 R 754252 CDS YP_003687908.1 297626145 9283541 complement(1061926..1062882) 1 NC_014215.1 recombinant protein active on 1- naphthyl actetate and 1- naphthyl propionate; carboxylic ester hydrolase 1062882 pf3004 9283541 pf3004 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003687908.1 1061926 R 754252 CDS YP_003687909.1 297626146 9284045 complement(1063072..1064253) 1 NC_014215.1 hypothetical protein 1064253 9284045 PFREUD_09450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687909.1 1063072 R 754252 CDS YP_003687910.1 297626147 9282504 complement(1064339..1065535) 1 NC_014215.1 L-aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-glutamate; aspartate transaminase 1065535 tyrB 9282504 tyrB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate transaminase YP_003687910.1 1064339 R 754252 CDS YP_003687911.1 297626148 9284446 1065790..1068537 1 NC_014215.1 pyruvate + Enzyme N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue acetyltransferase]S-acetyldihydrolipoyllysine + CO2 , The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); 2-oxo-acid dehydrogenase subunit E1 1068537 aceE 9284446 aceE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-oxo-acid dehydrogenase subunit E1 YP_003687911.1 1065790 D 754252 CDS YP_003687912.1 297626149 9283289 1068639..1069064 1 NC_014215.1 hypothetical protein 1069064 9283289 PFREUD_09480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687912.1 1068639 D 754252 CDS YP_003687913.1 297626150 9282505 complement(1069099..1070892) 1 NC_014215.1 ABC transporter ATP-binding protein 1070892 9282505 PFREUD_09490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687913.1 1069099 R 754252 CDS YP_003687914.1 297626151 9282506 1071142..1071594 1 NC_014215.1 Belongs to the small heat shock protein (HSP20) family.These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterized by the presence of a conserved C-terminal domain of about 100 residues.; molecular chaperone Hsp20 1071594 hsp20 9282506 hsp20 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone Hsp20 YP_003687914.1 1071142 D 754252 CDS YP_003687915.1 297626152 9283725 1071867..1073258 1 NC_014215.1 amino acid ABC transporter permease 1073258 9283725 PFREUD_09510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003687915.1 1071867 D 754252 CDS YP_003687916.1 297626153 9282507 1073255..1074115 1 NC_014215.1 carbon-nitrogen hydrolase 1074115 9282507 PFREUD_09520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbon-nitrogen hydrolase YP_003687916.1 1073255 D 754252 CDS YP_003687918.1 297626155 9282509 complement(1074294..1075631) 1 NC_014215.1 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde +; 4-aminobutyrate aminotransferase 1075631 gabT 9282509 gabT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-aminobutyrate aminotransferase YP_003687918.1 1074294 R 754252 CDS YP_003687919.1 297626156 9283590 1075935..1076741 1 NC_014215.1 FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins (Delpierre et al., 2000).; fructosamine kinase 1076741 fnk 9283590 fnk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 fructosamine kinase YP_003687919.1 1075935 D 754252 CDS YP_003687920.1 297626157 9282510 complement(1076930..1077391) 1 NC_014215.1 It does however suggest that Yqey and its relatives have a role in tRNA metabolism.; hypothetical protein 1077391 9282510 PFREUD_09570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687920.1 1076930 R 754252 CDS YP_003687921.1 297626158 9282511 1077486..1078595 1 NC_014215.1 voir aussi #2872 (RF-1); peptide chain release factor 2 1078595 prfB 9282511 prfB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptide chain release factor 2 YP_003687921.1 1077486 D 754252 CDS YP_003687922.1 297626159 9284116 1078747..1079433 1 NC_014215.1 ABC transporter ATP-binding protein 1079433 ftsE 9284116 ftsE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687922.1 1078747 D 754252 CDS YP_003687923.1 297626160 9283577 1079472..1080389 1 NC_014215.1 cell division protein 1080389 ftsX 9283577 ftsX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell division protein YP_003687923.1 1079472 D 754252 CDS YP_003687924.1 297626161 9283583 1080393..1081775 1 NC_014215.1 hypothetical protein 1081775 9283583 PFREUD_09610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687924.1 1080393 D 754252 CDS YP_003687925.1 297626162 9282512 1081959..1083911 1 NC_014215.1 hypothetical protein 1083911 9282512 PFREUD_09620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687925.1 1081959 D 754252 CDS YP_003687926.1 297626163 9282513 1084062..1084544 1 NC_014215.1 SmpB SsrA-binding protein 1084544 smpB 9282513 smpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 SmpB SsrA-binding protein YP_003687926.1 1084062 D 754252 CDS YP_003687927.1 297626164 9284287 1084628..1085275 1 NC_014215.1 hypothetical protein 1085275 9284287 PFREUD_09640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687927.1 1084628 D 754252 CDS YP_003687928.1 297626165 9282514 1085981..1086547 1 NC_014215.1 hypothetical protein 1086547 9282514 PFREUD_09650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687928.1 1085981 D 754252 CDS YP_003687929.1 297626166 9282515 1086683..1087423 1 NC_014215.1 two-component system response regulator 1087423 9282515 PFREUD_09660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system response regulator YP_003687929.1 1086683 D 754252 CDS YP_003687930.1 297626167 9282516 1087505..1088314 1 NC_014215.1 Members of phosphoribosyltransferase (PRT) are catalytic and are regulatory proteins involved in nucleotide synthesis and salvage. Not all PRT proteins are enzymes. For example, in some bacteria PRT proteins regulate the expression of purine and pyrimidine synthetic genes.; phosphoribosyltransferase 1088314 prt 9282516 prt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosyltransferase YP_003687930.1 1087505 D 754252 CDS YP_003687931.1 297626168 9284127 1088470..1089066 1 NC_014215.1 ribosomal S30AE, sigma 54 modulation protein 1089066 9284127 PFREUD_09680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribosomal S30AE, sigma 54 modulation protein YP_003687931.1 1088470 D 754252 CDS YP_003687932.1 297626169 9282517 1089311..1092160 1 NC_014215.1 SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner. SecA possesses the ATPase activity.; preprotein translocase subunit SecA 1092160 9282517 PFREUD_09690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 preprotein translocase subunit SecA YP_003687932.1 1089311 D 754252 CDS YP_003687933.1 297626170 9282518 complement(1092200..1092583) 1 NC_014215.1 hypothetical protein 1092583 9282518 PFREUD_09700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687933.1 1092200 R 754252 CDS YP_003687934.1 297626171 9282519 1092823..1093332 1 NC_014215.1 hypothetical protein 1093332 9282519 PFREUD_09710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687934.1 1092823 D 754252 CDS YP_003687935.1 297626172 9282520 1093334..1093537 1 NC_014215.1 hypothetical protein 1093537 9282520 PFREUD_09720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687935.1 1093334 D 754252 CDS YP_003687936.1 297626173 9282521 complement(1093596..1094072) 1 NC_014215.1 hypothetical protein 1094072 9282521 PFREUD_09730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687936.1 1093596 R 754252 CDS YP_003687937.1 297626174 9282522 1094204..1095085 1 NC_014215.1 metal-dependent phosphoesterase 1095085 PPA1328 9282522 PPA1328 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal-dependent phosphoesterase YP_003687937.1 1094204 D 754252 CDS YP_003687938.1 297626175 9284099 1095096..1096226 1 NC_014215.1 ATP + L-tryptophan + tRNA(Trp) <=> AMP + Pyrophosphate + L-tryptophanyl-tRNA(Trp); tryptophanyl-tRNA synthetase 1096226 trpS 9284099 trpS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tryptophanyl-tRNA synthetase YP_003687938.1 1095096 D 754252 CDS YP_003687939.1 297626176 9284432 complement(1096364..1097869) 1 NC_014215.1 DEAD/DEAH box helicase 1097869 9284432 PFREUD_09760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DEAD/DEAH box helicase YP_003687939.1 1096364 R 754252 CDS YP_003687940.1 297626177 9282523 1098145..1098900 1 NC_014215.1 hypothetical protein 1098900 9282523 PFREUD_09770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687940.1 1098145 D 754252 CDS YP_003687941.1 297626178 9282524 complement(1099087..1099311) 1 NC_014215.1 hypothetical protein 1099311 9282524 PFREUD_09780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687941.1 1099087 R 754252 CDS YP_003687942.1 297626179 9282525 complement(1099428..1100300) 1 NC_014215.1 PP2Cc, serine/threonine phosphatases 1100300 9282525 PFREUD_09790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PP2Cc, serine/threonine phosphatases YP_003687942.1 1099428 R 754252 CDS YP_003687943.1 297626180 9282526 complement(1100466..1100672) 1 NC_014215.1 Cold shock-like protein CspA 1100672 cspA 9282526 cspA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cold shock-like protein CspA YP_003687943.1 1100466 R 754252 CDS YP_003687944.1 297626181 9283448 1101012..1104383 1 NC_014215.1 REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA.; ATP-dependent DNA helicase 1104383 9283448 PFREUD_09810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent DNA helicase YP_003687944.1 1101012 D 754252 CDS YP_003687945.1 297626182 9282527 1104380..1107736 1 NC_014215.1 UvrD/REP helicase 1107736 urvD 9282527 urvD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UvrD/REP helicase YP_003687945.1 1104380 D 754252 CDS YP_003687946.1 297626183 9284461 1107746..1108636 1 NC_014215.1 NUDIX protein 1108636 9284461 PFREUD_09830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX protein YP_003687946.1 1107746 D 754252 CDS YP_003687947.1 297626184 9282528 complement(1108688..1110541) 1 NC_014215.1 exodeoxyribonuclease V subunit alpha 1110541 recD 9282528 recD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exodeoxyribonuclease V subunit alpha YP_003687947.1 1108688 R 754252 CDS YP_003687948.1 297626185 9284164 complement(1110528..1113890) 1 NC_014215.1 exodeoxyribonuclease V subunit beta 1113890 recB 9284164 recB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exodeoxyribonuclease V subunit beta YP_003687948.1 1110528 R 754252 CDS YP_003687949.1 297626186 9284162 complement(1113887..1117231) 1 NC_014215.1 Exonuc_V_gamma, exodeoxyribonuclease V, gamma subunit. The exodeoxyribonuclease V enzyme is a multi-subunit enzyme comprised of the proteins RecB, RecC (this family) and RecD. This enzyme plays an important role in homologous genetic recombination, repair of double strand DNA breaks resistance to UV irradiation and chemical DNA-damage.; exodeoxyribonuclease V subunit gamma 1117231 recC 9284162 recC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exodeoxyribonuclease V subunit gamma YP_003687949.1 1113887 R 754252 CDS YP_003687950.1 297626187 9284163 1117318..1117386 1 NC_014215.1 hypothetical protein 1117386 9284163 PFREUD_09870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687950.1 1117318 D 754252 CDS YP_003687951.1 297626188 9282529 1117364..1119520 1 NC_014215.1 DNA helicase 1119520 uvrD 9282529 uvrD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA helicase YP_003687951.1 1117364 D 754252 CDS YP_003687952.1 297626189 9284469 complement(1119577..1120602) 1 NC_014215.1 hypothetical protein 1120602 9284469 PFREUD_09890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687952.1 1119577 R 754252 CDS YP_003687953.1 297626190 9282530 complement(1120861..1121022) 1 NC_014215.1 hypothetical protein 1121022 9282530 PFREUD_09900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687953.1 1120861 R 754252 CDS YP_003687954.1 297626191 9282531 1121459..1122106 1 NC_014215.1 metal dependent hydrolase 1122106 9282531 PFREUD_09910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal dependent hydrolase YP_003687954.1 1121459 D 754252 CDS YP_003687955.1 297626192 9282532 complement(1122138..1123580) 1 NC_014215.1 hypothetical protein 1123580 9282532 PFREUD_09920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687955.1 1122138 R 754252 CDS YP_003687957.1 297626194 9282534 1123782..1124825 1 NC_014215.1 Secreted protease with a PDZ domain 1124825 9282534 PFREUD_09940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Secreted protease with a PDZ domain YP_003687957.1 1123782 D 754252 CDS YP_003687958.1 297626195 9282535 1124944..1125543 1 NC_014215.1 hypothetical protein 1125543 9282535 PFREUD_09950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687958.1 1124944 D 754252 CDS YP_003687959.1 297626196 9282536 1125540..1128479 1 NC_014215.1 hypothetical protein 1128479 9282536 PFREUD_09960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687959.1 1125540 D 754252 CDS YP_003687960.1 297626197 9282537 complement(1128563..1129927) 1 NC_014215.1 Zn dependent peptidase 1129927 9282537 PFREUD_09970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Zn dependent peptidase YP_003687960.1 1128563 R 754252 CDS YP_003687961.1 297626198 9282538 complement(1129927..1131198) 1 NC_014215.1 Zn-dependent peptidase 1131198 9282538 PFREUD_09980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Zn-dependent peptidase YP_003687961.1 1129927 R 754252 CDS YP_003687962.1 297626199 9282539 1131313..1132557 1 NC_014215.1 peptide + H2O <=> L-proline + peptide; proline iminopeptidase 1132557 pip1 9282539 pip1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 proline iminopeptidase YP_003687962.1 1131313 D 754252 CDS YP_003687963.1 297626200 9284075 1132724..1133014 1 NC_014215.1 acetyltransferase 1133014 9284075 PFREUD_10000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003687963.1 1132724 D 754252 CDS YP_003687964.1 297626201 9282540 1133177..1134322 1 NC_014215.1 Dethiobiotin + Sulfur + 2 S-adenosyl-L-methionine <=> biotin + 2 L-methionine + 2 5prim-deoxyadenosine; biotin synthase 1134322 bioB 9282540 bioB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 biotin synthase YP_003687964.1 1133177 D 754252 CDS YP_003687965.1 297626202 9282541 1134690..1136213 1 NC_014215.1 ABC transporter substrate-binding protein 1136213 9282541 PFREUD_10030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter substrate-binding protein YP_003687965.1 1134690 D 754252 CDS YP_003687966.1 297626203 9282542 1136235..1137188 1 NC_014215.1 ABC transporter permease 1137188 9282542 PFREUD_10040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003687966.1 1136235 D 754252 CDS YP_003687967.1 297626204 9282543 1137185..1138000 1 NC_014215.1 peptide ABC transporter permease 1138000 9282543 PFREUD_10050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptide ABC transporter permease YP_003687967.1 1137185 D 754252 CDS YP_003687968.1 297626205 9282544 1138002..1138859 1 NC_014215.1 ABC transporter ATP-binding protein 1138859 9282544 PFREUD_10060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687968.1 1138002 D 754252 CDS YP_003687969.1 297626206 9282545 1138852..1139679 1 NC_014215.1 ABC transporter ATP-binding protein 1139679 9282545 PFREUD_10070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003687969.1 1138852 D 754252 CDS YP_003687970.1 297626207 9282546 1139740..1140933 1 NC_014215.1 erythronate-4-phosphate + NAD+ = 2-oxo-3-hydroxy-4-phosphobutanoate + NADH and 3-phosphoglycerate + NAD+ = 3-phospho-hydroxypyruvate + NADH; D-3-phosphoglycerate dehydrogenase 1140933 9282546 PFREUD_10080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-3-phosphoglycerate dehydrogenase YP_003687970.1 1139740 D 754252 CDS YP_003687972.1 297626209 9282550 complement(1142091..1143038) 1 NC_014215.1 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; exopolysaccharide biosynthesis protein 1143038 9282550 PFREUD_10120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exopolysaccharide biosynthesis protein YP_003687972.1 1142091 R 754252 CDS YP_003687973.1 297626210 9282551 1143195..1143830 1 NC_014215.1 hypothetical protein 1143830 9282551 PFREUD_10130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687973.1 1143195 D 754252 CDS YP_003687974.1 297626211 9282552 1143827..1144639 1 NC_014215.1 hypothetical protein 1144639 9282552 PFREUD_10140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687974.1 1143827 D 754252 CDS YP_003687975.1 297626212 9282553 1144636..1146369 1 NC_014215.1 hypothetical protein 1146369 9282553 PFREUD_10150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687975.1 1144636 D 754252 CDS YP_003687976.1 297626213 9282554 complement(1146423..1147238) 1 NC_014215.1 monophosphatase 1147238 9282554 PFREUD_10160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 monophosphatase YP_003687976.1 1146423 R 754252 CDS YP_003687977.1 297626214 9282555 complement(1147292..1148362) 1 NC_014215.1 The engC protein is an unusual, circularly permuted GTPase that catalyzes rapid hydrolysis of GTP with comparatively slow catalytic turnover.; GTPase 1148362 engC 9282555 engC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTPase YP_003687977.1 1147292 R 754252 CDS YP_003687978.1 297626215 9283534 complement(1148359..1149711) 1 NC_014215.1 phosphoenolpyruvate + Shikimate 3-phosphate <=> Orthophosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate; 3-phosphoshikimate 1-carboxyvinyltransferase 1149711 aroA 9283534 aroA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-phosphoshikimate 1-carboxyvinyltransferase YP_003687978.1 1148359 R 754252 CDS YP_003687979.1 297626216 9283338 1149859..1150611 1 NC_014215.1 hypothetical protein 1150611 9283338 PFREUD_10190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687979.1 1149859 D 754252 CDS YP_003687980.1 297626217 9282556 1150686..1151339 1 NC_014215.1 RNA polymerase sigma-70 factor, sigma-E factor 1151339 rpoE 9282556 rpoE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RNA polymerase sigma-70 factor, sigma-E factor YP_003687980.1 1150686 D 754252 CDS YP_003687981.1 297626218 9284233 1151341..1151643 1 NC_014215.1 anti-sigma factor 1151643 9284233 PFREUD_10210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anti-sigma factor YP_003687981.1 1151341 D 754252 CDS YP_003687982.1 297626219 9282557 complement(1151811..1151885) 1 NC_014215.1 hypothetical protein 1151885 9282557 PFREUD_10220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687982.1 1151811 R 754252 CDS YP_003687983.1 297626220 9282558 1152129..1153637 1 NC_014215.1 Sensory transduction histidine kinase 1153637 9282558 PFREUD_10230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sensory transduction histidine kinase YP_003687983.1 1152129 D 754252 CDS YP_003687984.1 297626221 9282559 complement(1153742..1153990) 1 NC_014215.1 transcription factor WhiB 1153990 whiB2 9282559 whiB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription factor WhiB YP_003687984.1 1153742 R 754252 CDS YP_003687985.1 297626222 9284474 complement(1154235..1158020) 1 NC_014215.1 Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2); 2-oxoglutarate dehydrogenase, E1 and E2 components 1158020 odhA 9284474 odhA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-oxoglutarate dehydrogenase, E1 and E2 components YP_003687985.1 1154235 R 754252 CDS YP_003687986.1 297626223 9283981 complement(1158090..1159496) 1 NC_014215.1 hypothetical protein 1159496 9283981 PFREUD_10260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687986.1 1158090 R 754252 CDS YP_003687987.1 297626224 9282560 complement(1159489..1160784) 1 NC_014215.1 hypothetical protein 1160784 9282560 PFREUD_10270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687987.1 1159489 R 754252 CDS YP_003687988.1 297626225 9282561 complement(1160925..1162322) 1 NC_014215.1 hypothetical protein 1162322 9282561 PFREUD_10280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687988.1 1160925 R 754252 CDS YP_003687989.1 297626226 9282562 1162566..1163768 1 NC_014215.1 hypothetical protein 1163768 9282562 PFREUD_10290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003687989.1 1162566 D 754252 CDS YP_003687990.1 297626227 9282563 1163371..1165002 1 NC_014215.1 lysine metabolism meso-2,6-diaminoheptanedioate <=> L-lysine + CO2; diaminopimelate decarboxylase 1165002 lysA 9282563 lysA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 diaminopimelate decarboxylase YP_003687990.1 1163371 D 754252 CDS YP_003687991.1 297626228 9282564 1165013..1166338 1 NC_014215.1 L-Homoserine + NAD+ <=> L-aspartate 4-semialdehyde + NADH + H+ and L-Homoserine + NADP+ <=> L-aspartate 4-semialdehyde + NADPH + H+; Homoserine dehydrogenase 1166338 thrA/hom 9282564 thrA/hom Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Homoserine dehydrogenase YP_003687991.1 1165013 D 754252 CDS YP_003687992.1 297626229 9284337 1166347..1166970 1 NC_014215.1 O-phospho-L-serine + H2O <=> L-serine + Orthophosphate and D-O-phosphoserine + H2O <=> D-serine + Orthophosphate; bifunctional phosphoserine phosphatase/homoserine phosphotransferase 1166970 serB/thrH 9284337 serB/thrH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 bifunctional phosphoserine phosphatase/homoserine phosphotransferase YP_003687992.1 1166347 D 754252 CDS YP_003687993.1 297626230 9284277 1167364..1169334 1 NC_014215.1 transcription termination factor Rho 1169334 9284277 PFREUD_10340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription termination factor Rho YP_003687993.1 1167364 D 754252 CDS YP_003687994.1 297626231 9282565 1169471..1169695 1 NC_014215.1 50S ribosomal protein L31 1169695 rpmE 9282565 rpmE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L31 YP_003687994.1 1169471 D 754252 CDS YP_003687995.1 297626232 9284226 1169803..1170882 1 NC_014215.1 voir aussi #2872; peptide chain release factor 1 1170882 prfA 9284226 prfA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptide chain release factor 1 YP_003687995.1 1169803 D 754252 CDS YP_003687996.1 297626233 9284115 1170879..1171757 1 NC_014215.1 methylase 1171757 hemK 9284115 hemK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylase YP_003687996.1 1170879 D 754252 CDS YP_003687997.1 297626234 9283690 1171754..1172632 1 NC_014215.1 Sua5_yciO_yrdC, yrdC domain. This domain has been shown to preferentially bind to dsRNA. The domain is found in SUA5 as well as HypF and YrdC; Sua5/YciO/YrdC/YwlC 1172632 9283690 PFREUD_10380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sua5/YciO/YrdC/YwlC YP_003687997.1 1171754 D 754252 CDS YP_003687998.1 297626235 9282566 1172641..1173777 1 NC_014215.1 Catalyzes the formation of UDP-PP-N-acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to the peptidoglycan of B.subtilis. UDP-N-acetyl-D-glucosamine + UDP phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-undecaprenol; UDP-phosphate alpha-N-acetylglucosaminyltransferase 1173777 tagO 9282566 tagO Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-phosphate alpha-N-acetylglucosaminyltransferase YP_003687998.1 1172641 D 754252 CDS YP_003688000.1 297626237 9282567 1173855..1174292 1 NC_014215.1 hypothetical protein 1174292 9282567 PFREUD_10410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688000.1 1173855 D 754252 CDS YP_003688001.1 297626238 9282568 1174289..1174513 1 NC_014215.1 hypothetical protein 1174513 9282568 PFREUD_10420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688001.1 1174289 D 754252 CDS YP_003688002.1 297626239 9282569 1174506..1175387 1 NC_014215.1 Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane [H]. ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out); ATP synthase F1F0 subunit A 1175387 atpB 9282569 atpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase F1F0 subunit A YP_003688002.1 1174506 D 754252 CDS YP_003688003.1 297626240 9283366 1175433..1175651 1 NC_014215.1 This is one of the three subunits of the nonenzymatic component (CF(0) subunit) of the ATPase complex [H]; ATP synthase F1F0 subunit C 1175651 atpE 9283366 atpE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase F1F0 subunit C YP_003688003.1 1175433 D 754252 CDS YP_003688004.1 297626241 9283369 1175662..1176216 1 NC_014215.1 ATP synthase F0F1 subunit B 1176216 atpF 9283369 atpF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase F0F1 subunit B YP_003688004.1 1175662 D 754252 CDS YP_003688005.1 297626242 9283370 1176213..1176992 1 NC_014215.1 This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction [H]. ATP + H2O + H+(In) = ADP + phosphate + H+(Out); ATP synthase subunit delta 1176992 atpH 9283370 atpH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase subunit delta YP_003688005.1 1176213 D 754252 CDS YP_003688006.1 297626243 9283372 1176998..1178704 1 NC_014215.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha subunit is a regulatory subunit; ATP synthase subunit alpha 1178704 atpA 9283372 atpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase subunit alpha YP_003688006.1 1176998 D 754252 CDS YP_003688007.1 297626244 9283365 1178707..1179642 1 NC_014215.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma subunit is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.; ATP synthase subunit gamma 1179642 atpG 9283365 atpG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase subunit gamma YP_003688007.1 1178707 D 754252 CDS YP_003688008.1 297626245 9283371 1179643..1181094 1 NC_014215.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; ATP synthase subunit beta 1181094 atpD 9283371 atpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase subunit beta YP_003688008.1 1179643 D 754252 CDS YP_003688009.1 297626246 9283368 1181094..1181561 1 NC_014215.1 Produces ATP from ADP in the presence of a proton gradient across the membrane.; ATP synthase subunit epsilon 1181561 atpC 9283368 atpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP synthase subunit epsilon YP_003688009.1 1181094 D 754252 CDS YP_003688010.1 297626247 9283367 1181603..1182061 1 NC_014215.1 hypothetical protein 1182061 9283367 PFREUD_10510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688010.1 1181603 D 754252 CDS YP_003688011.1 297626248 9282570 1182085..1183149 1 NC_014215.1 lipoate-protein ligase A 1183149 lplA 9282570 lplA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lipoate-protein ligase A YP_003688011.1 1182085 D 754252 CDS YP_003688012.1 297626249 9283835 complement(1183324..1183932) 1 NC_014215.1 This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase converting CNB12 to AdoB12.; cobalamin adenosyltransferase 1183932 9283835 PFREUD_10530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalamin adenosyltransferase YP_003688012.1 1183324 R 754252 CDS YP_003688013.1 297626250 9282571 complement(1184011..1184841) 1 NC_014215.1 carboxylic ester hydrolase 1184841 pf1509 9282571 pf1509 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003688013.1 1184011 R 754252 CDS YP_003688014.1 297626251 9284032 complement(1184838..1185116) 1 NC_014215.1 hypothetical protein 1185116 9284032 PFREUD_10550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688014.1 1184838 R 754252 CDS YP_003688015.1 297626252 9282572 1185210..1185920 1 NC_014215.1 nuclease of the RecB family 1185920 9282572 PFREUD_10560 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nuclease of the RecB family YP_003688015.1 1185210 D 754252 CDS YP_003688016.1 297626253 9282573 complement(1185961..1187754) 1 NC_014215.1 hypothetical protein 1187754 9282573 PFREUD_10570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688016.1 1185961 R 754252 CDS YP_003688017.1 297626254 9282574 complement(1187913..1188488) 1 NC_014215.1 PlsC, phosphate acyltransferases 1188488 plsC2 9282574 plsC2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PlsC, phosphate acyltransferases YP_003688017.1 1187913 R 754252 CDS YP_003688018.1 297626255 9284082 complement(1188644..1189090) 1 NC_014215.1 (R)-2-methyl-3-oxopropanoyl-CoA <=> (S)-2-methyl-3-oxopropanoyl-CoA; methylmalonyl-CoA epimerase 1189090 9284082 PFREUD_10590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylmalonyl-CoA epimerase YP_003688018.1 1188644 R 754252 CDS YP_003688019.1 297626256 9282575 complement(1189322..1190314) 1 NC_014215.1 thioredoxin 1190314 trxA3 9282575 trxA3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin YP_003688019.1 1189322 R 754252 CDS YP_003688020.1 297626257 9284437 1190447..1192078 1 NC_014215.1 D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate; phosphoglucomutase 1192078 pgm1 9284437 pgm1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglucomutase YP_003688020.1 1190447 D 754252 CDS YP_003688021.1 297626258 9284062 complement(1192193..1192978) 1 NC_014215.1 NUDIX hydrolase 1192978 9284062 PFREUD_10620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003688021.1 1192193 R 754252 CDS YP_003688022.1 297626259 9282576 complement(1193014..1194918) 1 NC_014215.1 1,4-alpha-D-glucan <=> glycogen; 1,4-alpha-glucan-branching protein 1194918 glgB 9282576 glgB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1,4-alpha-glucan-branching protein YP_003688022.1 1193014 R 754252 CDS YP_003688023.1 297626260 9283613 complement(1194911..1196248) 1 NC_014215.1 trehalose biosynthesis protein 1196248 PPA1112 9283613 PPA1112 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 trehalose biosynthesis protein YP_003688023.1 1194911 R 754252 CDS YP_003688024.1 297626261 9284098 complement(1196264..1198063) 1 NC_014215.1 Catalyzes the conversion of maltose into alpha,alpha-trehalose by transglucosylation. Annotated from blastp from sequence of (Cardoso et al, 2007 PubMed 17185556); trehalose synthase 1198063 treS 9284098 treS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 trehalose synthase YP_003688024.1 1196264 R 754252 CDS YP_003688025.1 297626262 9284420 complement(1198149..1200263) 1 NC_014215.1 glycosyl hydrolase family protein 1200263 glgE 9284420 glgE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyl hydrolase family protein YP_003688025.1 1198149 R 754252 CDS YP_003688026.1 297626263 9283615 1200410..1202980 1 NC_014215.1 (1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.; alpha-glucan phosphorylase 1202980 glgP 9283615 glgP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alpha-glucan phosphorylase YP_003688026.1 1200410 D 754252 CDS YP_003688027.1 297626264 9283616 complement(1203143..1204036) 1 NC_014215.1 hypothetical protein 1204036 9283616 PFREUD_10680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688027.1 1203143 R 754252 CDS YP_003688028.1 297626265 9282577 complement(1203997..1204569) 1 NC_014215.1 hypothetical protein 1204569 9282577 PFREUD_10690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688028.1 1203997 R 754252 CDS YP_003688029.1 297626266 9282578 complement(1204802..1207093) 1 NC_014215.1 glycogen debranching protein 1207093 glgX/treX 9282578 glgX/treX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycogen debranching protein YP_003688029.1 1204802 R 754252 CDS YP_003688030.1 297626267 9283618 1207251..1208324 1 NC_014215.1 S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1208324 trmU 9283618 trmU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase YP_003688030.1 1207251 D 754252 CDS YP_003688031.1 297626268 9284425 1208370..1209356 1 NC_014215.1 5-methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-methionine; methionine synthase, vitamin-B12 independent 1209356 metE 9284425 metE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionine synthase, vitamin-B12 independent YP_003688031.1 1208370 D 754252 CDS YP_003688032.1 297626269 9283877 1209425..1209628 1 NC_014215.1 hypothetical protein 1209628 9283877 PFREUD_10730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688032.1 1209425 D 754252 CDS YP_003688033.1 297626270 9282579 complement(1209648..1210274) 1 NC_014215.1 his family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.; amino acid-binding protein 1210274 9282579 PFREUD_10740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid-binding protein YP_003688033.1 1209648 R 754252 CDS YP_003688034.1 297626271 9282580 1210495..1210797 1 NC_014215.1 ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.; glutamyl-tRNA(Gln) amidotransferase subunit C 1210797 gatC 9282580 gatC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamyl-tRNA(Gln) amidotransferase subunit C YP_003688034.1 1210495 D 754252 CDS YP_003688035.1 297626272 9283602 1210805..1212337 1 NC_014215.1 Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln); glutamyl-tRNA(Gln) amidotransferase subunit A 1212337 gatA 9283602 gatA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamyl-tRNA(Gln) amidotransferase subunit A YP_003688035.1 1210805 D 754252 CDS YP_003688036.1 297626273 9283600 1212334..1213845 1 NC_014215.1 ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.; aspartyl/glutamyl-tRNA amidotransferase subunit B 1213845 gatB 9283600 gatB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_003688036.1 1212334 D 754252 CDS YP_003688037.1 297626274 9283601 1214346..1216475 1 NC_014215.1 hypothetical protein 1216475 9283601 PFREUD_10780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688037.1 1214346 D 754252 CDS YP_003688038.1 297626275 9284037 complement(1217819..1218952) 1 NC_014215.1 Belongs to the peptidase M24B family, cell membrane; multi-pass membrane protein potential, potentially binds 2 manganese ions per subunit; dipeptidase pepE 1218952 pepE 9284037 pepE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dipeptidase pepE YP_003688038.1 1217819 R 754252 CDS YP_003688039.1 297626276 9284028 1219425..1219847 1 NC_014215.1 PTS system, mannose/fructose/sorbose family, IIA component subfamily 1219847 9284028 PFREUD_10820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PTS system, mannose/fructose/sorbose family, IIA component subfamily YP_003688039.1 1219425 D 754252 CDS YP_003688040.1 297626277 9282582 complement(1219879..1220529) 1 NC_014215.1 contains C-terminal CBS domain; transcriptional regulator 1220529 9282582 PFREUD_10830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688040.1 1219879 R 754252 CDS YP_003688041.1 297626278 9282583 complement(1220531..1221235) 1 NC_014215.1 highly similar to Swiss-Prot entry P0A192; branched-chain amino acid ABC transporter ATP-binding protein 1221235 livF 9282583 livF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 branched-chain amino acid ABC transporter ATP-binding protein YP_003688041.1 1220531 R 754252 CDS YP_003688042.1 297626279 9283829 complement(1221228..1222019) 1 NC_014215.1 highly similar with Swiss-Prot entries P0A194 and P0A958, COG; branched-chain amino acid ABC transporter ATP-binding protein 1222019 livG 9283829 livG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 branched-chain amino acid ABC transporter ATP-binding protein YP_003688042.1 1221228 R 754252 CDS YP_003688043.1 297626280 9283830 complement(1222016..1223029) 1 NC_014215.1 31% identity with Swiss-Prot entry P30296 and P22729. Part of the binding-protein-dependent transport system for branched-subunit amino acids. Probably responsible for the translocation of the substrates across the membrane.; branched-chain amino acid ABC transporter permease 1223029 braE 9283830 braE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 branched-chain amino acid ABC transporter permease YP_003688043.1 1222016 R 754252 CDS YP_003688044.1 297626281 9283386 complement(1223032..1223916) 1 NC_014215.1 Annotated from similarity Swiss-Prot entry P21627. Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I).; branched-chain amino acid ABC transporter permease 1223916 braD 9283386 braD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 branched-chain amino acid ABC transporter permease YP_003688044.1 1223032 R 754252 CDS YP_003688045.1 297626282 9283385 complement(1224013..1225176) 1 NC_014215.1 amino acid-binding protein 1225176 braC 9283385 braC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid-binding protein YP_003688045.1 1224013 R 754252 CDS YP_003688046.1 297626283 9283384 complement(1225372..1226772) 1 NC_014215.1 In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes. Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.; dihydrolipoamide dehydrogenase 1226772 lpd 9283384 lpd Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrolipoamide dehydrogenase YP_003688046.1 1225372 R 754252 CDS YP_003688047.1 297626284 9283833 1226919..1228454 1 NC_014215.1 cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1228454 MurA 9283833 MurA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_003688047.1 1226919 D 754252 CDS YP_003688048.1 297626285 9283916 complement(1228545..1229414) 1 NC_014215.1 # ATP + Pyridoxal <=> ADP + Pyridoxal phosphate; Pyridoxal kinase 1229414 pdxY 9283916 pdxY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Pyridoxal kinase YP_003688048.1 1228545 R 754252 CDS YP_003688049.1 297626286 9284024 1229561..1230076 1 NC_014215.1 hypothetical protein 1230076 9284024 PFREUD_10920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688049.1 1229561 D 754252 CDS YP_003688050.1 297626287 9282584 1230124..1230918 1 NC_014215.1 glycerophosphodiester + H2O <=> Alcohol + sn-glycerol 3-phosphate; glycerophosphoryl diester phosphodiesterase 1230918 glpQ 9282584 glpQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerophosphoryl diester phosphodiesterase YP_003688050.1 1230124 D 754252 CDS YP_003688051.1 297626288 9283633 1231025..1231363 1 NC_014215.1 hypothetical protein 1231363 9283633 PFREUD_10940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688051.1 1231025 D 754252 CDS YP_003688052.1 297626289 9282585 complement(1231459..1232316) 1 NC_014215.1 GDP-mannose + Dolichyl phosphate <=> GDP + Dolichyl phosphate D-mannose; dolichyl-phosphate beta-D-mannosyltransferase 1232316 dpm 9282585 dpm Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dolichyl-phosphate beta-D-mannosyltransferase YP_003688052.1 1231459 R 754252 CDS YP_003688053.1 297626290 9283520 complement(1232288..1232371) 1 NC_014215.1 hypothetical protein 1232371 9283520 PFREUD_10960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688053.1 1232288 R 754252 CDS YP_003688054.1 297626291 9282586 complement(1232352..1233986) 1 NC_014215.1 hypothetical protein 1233986 9282586 PFREUD_10970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688054.1 1232352 R 754252 CDS YP_003688055.1 297626292 9282587 complement(1234080..1234544) 1 NC_014215.1 AsnC family transcriptional regulator 1234544 9282587 PFREUD_10980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 AsnC family transcriptional regulator YP_003688055.1 1234080 R 754252 CDS YP_003688056.1 297626293 9282588 complement(1234629..1235315) 1 NC_014215.1 methionine biosynthesis protein MetW 1235315 RED65_15082 9282588 RED65_15082 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionine biosynthesis protein MetW YP_003688056.1 1234629 R 754252 CDS YP_003688057.1 297626294 9284171 complement(1235312..1236508) 1 NC_014215.1 acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine; homoserine O-acetyltransferase 1236508 pf3022 9284171 pf3022 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 homoserine O-acetyltransferase YP_003688057.1 1235312 R 754252 CDS YP_003688058.1 297626295 9284046 complement(1236505..1236666) 1 NC_014215.1 hypothetical protein 1236666 9284046 PFREUD_11010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688058.1 1236505 R 754252 CDS YP_003688059.1 297626296 9282589 complement(1236747..1237754) 1 NC_014215.1 transporter 1237754 9282589 PFREUD_11020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transporter YP_003688059.1 1236747 R 754252 CDS YP_003688060.1 297626297 9282590 complement(1237751..1238641) 1 NC_014215.1 Binding-protein-dependent transport systems inner membrane component 1238641 9282590 PFREUD_11030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Binding-protein-dependent transport systems inner membrane component YP_003688060.1 1237751 R 754252 CDS YP_003688061.1 297626298 9282591 complement(1238949..1240529) 1 NC_014215.1 Integral membrane transport protein 1240529 9282591 PFREUD_11040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Integral membrane transport protein YP_003688061.1 1238949 R 754252 CDS YP_003688062.1 297626299 9282592 complement(1240721..1241185) 1 NC_014215.1 S-ribosylhomocysteine lyase 1241185 luxS 9282592 luxS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S-ribosylhomocysteine lyase YP_003688062.1 1240721 R 754252 CDS YP_003688063.1 297626300 9282593 complement(1241746..1242936) 1 NC_014215.1 Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment; phage integrase 1242936 int 9282593 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage integrase YP_003688063.1 1241746 R 754252 CDS YP_003688064.1 297626301 9283753 complement(1242929..1243144) 1 NC_014215.1 hypothetical protein 1243144 9283753 PFREUD_11080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688064.1 1242929 R 754252 CDS YP_003688065.1 297626302 9282594 complement(1243125..1243706) 1 NC_014215.1 hypothetical protein 1243706 9282594 PFREUD_11090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688065.1 1243125 R 754252 CDS YP_003688066.1 297626303 9282595 complement(1243717..1244199) 1 NC_014215.1 ssDNA-binding protein 1244199 9282595 PFREUD_11100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ssDNA-binding protein YP_003688066.1 1243717 R 754252 CDS YP_003688067.1 297626304 9282598 1247876..1248430 1 NC_014215.1 hypothetical protein 1248430 9282598 PFREUD_11130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688067.1 1247876 D 754252 CDS YP_003688068.1 297626305 9282599 1248527..1249483 1 NC_014215.1 ATPase AAA 1249483 9282599 PFREUD_11140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase AAA YP_003688068.1 1248527 D 754252 CDS YP_003688069.1 297626306 9282600 1249480..1252092 1 NC_014215.1 hypothetical protein 1252092 9282600 PFREUD_11150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688069.1 1249480 D 754252 CDS YP_003688070.1 297626307 9282601 1252145..1253644 1 NC_014215.1 hypothetical protein 1253644 9282601 PFREUD_11160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688070.1 1252145 D 754252 CDS YP_003688071.1 297626308 9282602 1254242..1255915 1 NC_014215.1 hypothetical protein 1255915 9282602 PFREUD_11170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688071.1 1254242 D 754252 CDS YP_003688072.1 297626309 9282603 complement(1256255..1256560) 1 NC_014215.1 ArsR family transcriptional regulator 1256560 arsR3 9282603 arsR3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003688072.1 1256255 R 754252 CDS YP_003688073.1 297626310 9283350 complement(1256553..1257074) 1 NC_014215.1 hypothetical protein 1257074 9283350 PFREUD_11190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688073.1 1256553 R 754252 CDS YP_003688074.1 297626311 9282604 1257245..1258120 1 NC_014215.1 multidrug DMT transporter permease 1258120 9282604 PFREUD_11200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 multidrug DMT transporter permease YP_003688074.1 1257245 D 754252 CDS YP_003688075.1 297626312 9282605 1258229..1259179 1 NC_014215.1 zinc-containing alcohol dehydrogenase 1259179 9282605 PFREUD_11210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 zinc-containing alcohol dehydrogenase YP_003688075.1 1258229 D 754252 CDS YP_003688076.1 297626313 9282606 complement(1259225..1259803) 1 NC_014215.1 TetR family transcriptional regulator 1259803 tetR6 9282606 tetR6 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003688076.1 1259225 R 754252 CDS YP_003688077.1 297626314 9282608 1261454..1261963 1 NC_014215.1 hypothetical protein 1261963 9282608 PFREUD_11250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688077.1 1261454 D 754252 CDS YP_003688078.1 297626315 9282609 complement(1261998..1263347) 1 NC_014215.1 GTP binding protein 1263347 engA 9282609 engA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP binding protein YP_003688078.1 1261998 R 754252 CDS YP_003688079.1 297626316 9283533 complement(1263462..1264133) 1 NC_014215.1 Cytidylate kinase EC:2.7.4.14 catalyses the phosphorylation of cytidine 5prime-monophosphate (dCMP) to cytidine 5prime-diphosphate (dCDP) in the presence of ATP or GTP; cytidylate kinase 1264133 cmk 9283533 cmk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cytidylate kinase YP_003688079.1 1263462 R 754252 CDS YP_003688080.1 297626317 9283427 complement(1264173..1265267) 1 NC_014215.1 Prephenate + NAD+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH + H+; prephenate dehydrogenase 1265267 tyrA 9283427 tyrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 prephenate dehydrogenase YP_003688080.1 1264173 R 754252 CDS YP_003688081.1 297626318 9284445 complement(1265269..1265994) 1 NC_014215.1 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Cleavage of peptide bonds with very broad specificity.; 20S proteasome subunit alpha 1265994 prcA 9284445 prcA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 20S proteasome subunit alpha YP_003688081.1 1265269 R 754252 CDS YP_003688082.1 297626319 9284114 complement(1265991..1266857) 1 NC_014215.1 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; 20S proteasome subunit beta 1266857 pcrB 9284114 pcrB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 20S proteasome subunit beta YP_003688082.1 1265991 R 754252 CDS YP_003688083.1 297626320 9284005 complement(1266850..1267920) 1 NC_014215.1 S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine; tRNA (adenine-N1-)-methyltransferase 1267920 9284005 PFREUD_11310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA (adenine-N1-)-methyltransferase YP_003688083.1 1266850 R 754252 CDS YP_003688084.1 297626321 9282610 complement(1267917..1268642) 1 NC_014215.1 HAD-superfamily hydrolase 1268642 9282610 PFREUD_11320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 HAD-superfamily hydrolase YP_003688084.1 1267917 R 754252 CDS YP_003688085.1 297626322 9282611 1268826..1270082 1 NC_014215.1 SppA, Periplasmic serine proteases 1270082 sppA 9282611 sppA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 SppA, Periplasmic serine proteases YP_003688085.1 1268826 D 754252 CDS YP_003688086.1 297626323 9284295 complement(1270340..1273831) 1 NC_014215.1 5-methyltetrahydrofolate + L-Homocysteine <=> Tetrahydrofolate + L-methionine; methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase) 1273831 metH 9284295 metH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase) YP_003688086.1 1270340 R 754252 CDS YP_003688087.1 297626324 9283880 1273959..1274789 1 NC_014215.1 hypothetical protein 1274789 9283880 PFREUD_11350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688087.1 1273959 D 754252 CDS YP_003688088.1 297626325 9282612 complement(1274890..1276221) 1 NC_014215.1 Paralogue with PF#2086 . Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.; aminopeptidase 1276221 pepC 9282612 pepC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminopeptidase YP_003688088.1 1274890 R 754252 CDS YP_003688089.1 297626326 9284027 complement(1276281..1276949) 1 NC_014215.1 D-ribulose 5-phosphate = D-xylulose 5-phosphate; Ribulose-phosphate 3-epimerase 1276949 rpe 9284027 rpe Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ribulose-phosphate 3-epimerase YP_003688089.1 1276281 R 754252 CDS YP_003688090.1 297626327 9284194 complement(1276978..1278297) 1 NC_014215.1 Sun, tRNA and rRNA cytosine-C5-methylases 1278297 9284194 PFREUD_11380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sun, tRNA and rRNA cytosine-C5-methylases YP_003688090.1 1276978 R 754252 CDS YP_003688091.1 297626328 9282613 complement(1278440..1279387) 1 NC_014215.1 L-methionyl-tRNA + 10-formyltetrahydrofolate <=> Tetrahydrofolate + N-formylmethionyl-tRNA; methionyl-tRNA formyltransferase 1279387 fmt 9282613 fmt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionyl-tRNA formyltransferase YP_003688091.1 1278440 R 754252 CDS YP_003688092.1 297626329 9283564 complement(1279465..1281486) 1 NC_014215.1 Recognizes a specific hairpin sequence on phiX ssDNA. This structure is then recognized and bound by proteins priB and priC. formation of the primosome proceeds with the subsequent actions of dnaB, dnaC, dnaT and primase. PriA then functions as a helicase within the primosome; Primosomal protein N 1281486 priA 9283564 priA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Primosomal protein N YP_003688092.1 1279465 R 754252 CDS YP_003688093.1 297626330 9284117 complement(1281597..1282787) 1 NC_014215.1 # Orthophosphate + Pyrophosphate + S-adenosyl-L-methionine <=> ATP + L-methionine + H2O / ATP + Selenomethionine + H2O <=> Orthophosphate + Pyrophosphate + Se-adenosylselenomethionine; S-adenosylmethionine synthetase 1282787 metK 9284117 metK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S-adenosylmethionine synthetase YP_003688093.1 1281597 R 754252 CDS YP_003688094.1 297626331 9283881 complement(1282853..1283209) 1 NC_014215.1 DNA-directed RNA polymerase subunit omega 1283209 rpoZ 9283881 rpoZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA-directed RNA polymerase subunit omega YP_003688094.1 1282853 R 754252 CDS YP_003688095.1 297626332 9284234 complement(1283281..1283901) 1 NC_014215.1 ATP + GMP <=> ADP + GDP; guanylate kinase 1283901 gmk 9284234 gmk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 guanylate kinase YP_003688095.1 1283281 R 754252 CDS YP_003688096.1 297626333 9283645 complement(1283905..1284216) 1 NC_014215.1 Integration host factor MihF 1284216 mihF 9283645 mihF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Integration host factor MihF YP_003688096.1 1283905 R 754252 CDS YP_003688097.1 297626334 9283888 complement(1284379..1285188) 1 NC_014215.1 Orotidine 5 prime-phosphate <=> UMP + CO2; orotidine 5-phosphate decarboxylase 1285188 pyrF 9283888 pyrF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 orotidine 5-phosphate decarboxylase YP_003688097.1 1284379 R 754252 CDS YP_003688098.1 297626335 9284156 complement(1285185..1286285) 1 NC_014215.1 dihydroorotate dehydrogenase 1286285 pyrD 9284156 pyrD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroorotate dehydrogenase YP_003688098.1 1285185 R 754252 CDS YP_003688099.1 297626336 9284154 complement(1286367..1289708) 1 NC_014215.1 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate ; Binds 3 manganese ions per subunit; carbamoyl-phosphate synthase large subunit 1289708 carb 9284154 carb Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbamoyl-phosphate synthase large subunit YP_003688099.1 1286367 R 754252 CDS YP_003688100.1 297626337 9283393 complement(1289708..1290892) 1 NC_014215.1 The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides; carbamoyl-phosphate synthase small subunit 1290892 carA 9283393 carA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbamoyl-phosphate synthase small subunit YP_003688100.1 1289708 R 754252 CDS YP_003688101.1 297626338 9283392 complement(1290889..1291074) 1 NC_014215.1 hypothetical protein 1291074 9283392 PFREUD_11490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688101.1 1290889 R 754252 CDS YP_003688102.1 297626339 9282614 complement(1291071..1291697) 1 NC_014215.1 NusB family. The NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination.; transcription antitermination factor NusB 1291697 nusB 9282614 nusB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription antitermination factor NusB YP_003688102.1 1291071 R 754252 CDS YP_003688103.1 297626340 9283978 complement(1291697..1292260) 1 NC_014215.1 elongation factor P 1292260 efp 9283978 efp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 elongation factor P YP_003688103.1 1291697 R 754252 CDS YP_003688104.1 297626341 9283532 complement(1292437..1294086) 1 NC_014215.1 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate <=> 3-Dehydroquinate + Orthophosphate; 3-dehydroquinate synthase 1294086 aroB 9283532 aroB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-dehydroquinate synthase YP_003688104.1 1292437 R 754252 CDS YP_003688105.1 297626342 9283339 complement(1294083..1295285) 1 NC_014215.1 5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> Chorismate + Orthophosphate; chorismate synthase 1295285 aroF 9283339 aroF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chorismate synthase YP_003688105.1 1294083 R 754252 CDS YP_003688106.1 297626343 9283342 complement(1295440..1296672) 1 NC_014215.1 4-amino-4-deoxychorismate <=> 4-aminobenzoate + pyruvate; aminodeoxychorismate lyase 1296672 9283342 PFREUD_11540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminodeoxychorismate lyase YP_003688106.1 1295440 R 754252 CDS YP_003688107.1 297626344 9282615 complement(1296647..1297192) 1 NC_014215.1 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination.; Holliday junction resolvase 1297192 9282615 PFREUD_11550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Holliday junction resolvase YP_003688107.1 1296647 R 754252 CDS YP_003688108.1 297626345 9282616 complement(1297176..1299863) 1 NC_014215.1 ATP + L-alanine + tRNA(Ala) <=> AMP + Pyrophosphate + L-Alanyl-tRNA; alanyl-tRNA synthetase 1299863 alaS 9282616 alaS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alanyl-tRNA synthetase YP_003688108.1 1297176 R 754252 CDS YP_003688109.1 297626346 9283305 complement(1300028..1301008) 1 NC_014215.1 (S)-Lactate + NAD+ <=> pyruvate + NADH + H+; L-Lactate dehydrogenase 1301008 ldh1 9283305 ldh1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-Lactate dehydrogenase YP_003688109.1 1300028 R 754252 CDS YP_003688110.1 297626347 9283813 complement(1301063..1302487) 1 NC_014215.1 ATPase 1302487 9283813 PFREUD_11580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase YP_003688110.1 1301063 R 754252 CDS YP_003688111.1 297626348 9282617 complement(1302612..1304459) 1 NC_014215.1 aspartyl-tRNA synthetase 1304459 aspS 9282617 aspS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartyl-tRNA synthetase YP_003688111.1 1302612 R 754252 CDS YP_003688112.1 297626349 9283364 complement(1304659..1305732) 1 NC_014215.1 hypothetical protein 1305732 9283364 PFREUD_11600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688112.1 1304659 R 754252 CDS YP_003688113.1 297626350 9282618 complement(1305941..1306756) 1 NC_014215.1 2-acetolactate <=> (R)-acetoin + CO2 - (S)-2-acetolactate <=> (R)-acetoin + CO2; alpha-acetolactate decarboxylase 1306756 aldC 9282618 aldC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alpha-acetolactate decarboxylase YP_003688113.1 1305941 R 754252 CDS YP_003688114.1 297626351 9283308 complement(1306870..1308201) 1 NC_014215.1 histidyl-tRNA synthetase 1308201 hisS 9283308 hisS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 histidyl-tRNA synthetase YP_003688114.1 1306870 R 754252 CDS YP_003688115.1 297626352 9283709 complement(1308201..1308887) 1 NC_014215.1 beta-lactamase 1308887 9283709 PFREUD_11630 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-lactamase YP_003688115.1 1308201 R 754252 CDS YP_003688116.1 297626353 9282619 1308919..1310163 1 NC_014215.1 hypothetical protein 1310163 9282619 PFREUD_11640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688116.1 1308919 D 754252 CDS YP_003688117.1 297626354 9282620 complement(1310244..1312595) 1 NC_014215.1 ATP + GTP <=> AMP + Guanosine 3 prime -diphosphate 5 prime -triphosphate; GTP pyrophosphokinase 1312595 relA 9282620 relA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP pyrophosphokinase YP_003688117.1 1310244 R 754252 CDS YP_003688118.1 297626355 9284173 complement(1312658..1313197) 1 NC_014215.1 AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.; adenine phosphoribosyltransferase 1313197 apt 9284173 apt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 adenine phosphoribosyltransferase YP_003688118.1 1312658 R 754252 CDS YP_003688119.1 297626356 9283316 complement(1313200..1314447) 1 NC_014215.1 multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC.; protein-export membrane protein SecF 1314447 secF 9283316 secF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein-export membrane protein SecF YP_003688119.1 1313200 R 754252 CDS YP_003688120.1 297626357 9284273 complement(1314447..1316165) 1 NC_014215.1 protein-export membrane protein secD 1316165 secD 9284273 secD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein-export membrane protein secD YP_003688120.1 1314447 R 754252 CDS YP_003688121.1 297626358 9284271 complement(1316193..1316696) 1 NC_014215.1 transmembrane domain in N-term; Preprotein translocase subunit YajC 1316696 yajC 9284271 yajC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Preprotein translocase subunit YajC YP_003688121.1 1316193 R 754252 CDS YP_003688122.1 297626359 9284484 complement(1316807..1317832) 1 NC_014215.1 The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing; Holliday junction ATP-dependent DNA helicase 1317832 ruvB 9284484 ruvB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Holliday junction ATP-dependent DNA helicase YP_003688122.1 1316807 R 754252 CDS YP_003688123.1 297626360 9284258 complement(1317896..1318507) 1 NC_014215.1 The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB; Holliday junction ATP-dependent DNA helicase 1318507 ruvA 9284258 ruvA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Holliday junction ATP-dependent DNA helicase YP_003688123.1 1317896 R 754252 CDS YP_003688124.1 297626361 9284257 complement(1318504..1319115) 1 NC_014215.1 # nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5terminal phosphate and a 3terminal hydroxyl group; Holliday junction resolvase 1319115 ruvC 9284257 ruvC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Holliday junction resolvase YP_003688124.1 1318504 R 754252 CDS YP_003688125.1 297626362 9284259 complement(1319367..1320167) 1 NC_014215.1 hypothetical protein 1320167 9284259 PFREUD_11730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688125.1 1319367 R 754252 CDS YP_003688126.1 297626363 9282621 complement(1320331..1321368) 1 NC_014215.1 N-acetyltransferase GCN5 1321368 9282621 PFREUD_11740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 N-acetyltransferase GCN5 YP_003688126.1 1320331 R 754252 CDS YP_003688127.1 297626364 9282622 complement(1321365..1322090) 1 NC_014215.1 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)- 1-(5-phosphoribosyl)imidazole-4-carboxamide.; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1322090 hisA 9282622 hisA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_003688127.1 1321365 R 754252 CDS YP_003688128.1 297626365 9283700 complement(1322159..1322836) 1 NC_014215.1 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.; imidazole glycerol phosphate synthase subunit HisH 1322836 hisH 9283700 hisH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 imidazole glycerol phosphate synthase subunit HisH YP_003688128.1 1322159 R 754252 CDS YP_003688129.1 297626366 9283707 complement(1322833..1323441) 1 NC_014215.1 imidazoleglycerol-phosphate dehydratase 1323441 hisB 9283707 hisB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 imidazoleglycerol-phosphate dehydratase YP_003688129.1 1322833 R 754252 CDS YP_003688130.1 297626367 9283701 complement(1323438..1324661) 1 NC_014215.1 L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.; histidinol-phosphate aminotransferase 1324661 hisC 9283701 hisC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 histidinol-phosphate aminotransferase YP_003688130.1 1323438 R 754252 CDS YP_003688131.1 297626368 9283702 complement(1324658..1325971) 1 NC_014215.1 L-histidinol + 2 NAD+ = L-histidine + 2 NADH; histidinol dehydrogenase 1325971 hisD 9283702 hisD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 histidinol dehydrogenase YP_003688131.1 1324658 R 754252 CDS YP_003688132.1 297626369 9283703 1326085..1326849 1 NC_014215.1 hypothetical protein 1326849 9283703 PFREUD_11800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688132.1 1326085 D 754252 CDS YP_003688133.1 297626370 9282623 1326895..1327413 1 NC_014215.1 YbaC/EbsC protein 1327413 ybaK/EbsC 9282623 ybaK/EbsC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 YbaC/EbsC protein YP_003688133.1 1326895 D 754252 CDS YP_003688134.1 297626371 9284486 complement(1327450..1328175) 1 NC_014215.1 hypothetical protein 1328175 9284486 PFREUD_11820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688134.1 1327450 R 754252 CDS YP_003688135.1 297626372 9282624 complement(1328248..1331820) 1 NC_014215.1 DNA polymerase III subunit alpha 1331820 dnaE1 9282624 dnaE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase III subunit alpha YP_003688135.1 1328248 R 754252 CDS YP_003688136.1 297626373 9283509 1332046..1332717 1 NC_014215.1 hypothetical protein 1332717 9283509 PFREUD_11840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688136.1 1332046 D 754252 CDS YP_003688137.1 297626374 9282625 complement(1332738..1334207) 1 NC_014215.1 2 L-glutamate + NADP+ <=> L-glutamine + 2-Oxoglutarate + NADPH + H+; glutamate synthase small subunit 1334207 gltD 9282625 gltD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate synthase small subunit YP_003688137.1 1332738 R 754252 CDS YP_003688138.1 297626375 9283638 complement(1334200..1338708) 1 NC_014215.1 2 L-glutamate + 2 Oxidized ferredoxin <=> L-glutamine + 2-Oxoglutarate + 2 Reduced ferredoxin; glutamate synthase large subunit 1338708 gltB 9283638 gltB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate synthase large subunit YP_003688138.1 1334200 R 754252 CDS YP_003688139.1 297626376 9283637 complement(1338852..1339823) 1 NC_014215.1 transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins; prolipoprotein diacylglyceryl transferase 1339823 lgt 9283637 lgt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 prolipoprotein diacylglyceryl transferase YP_003688139.1 1338852 R 754252 CDS YP_003688140.1 297626377 9283825 complement(1339820..1340716) 1 NC_014215.1 tryptophan synthase subunit alpha 1340716 trpA 9283825 trpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tryptophan synthase subunit alpha YP_003688140.1 1339820 R 754252 CDS YP_003688141.1 297626378 9284426 complement(1340713..1341966) 1 NC_014215.1 L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O; tryptophan synthase subunit beta 1341966 trpB 9284426 trpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tryptophan synthase subunit beta YP_003688141.1 1340713 R 754252 CDS YP_003688142.1 297626379 9284427 complement(1341959..1342819) 1 NC_014215.1 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.; indole-3-glycerol phosphate synthase 1342819 trpC 9284427 trpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 indole-3-glycerol phosphate synthase YP_003688142.1 1341959 R 754252 CDS YP_003688143.1 297626380 9284429 complement(1342816..1344348) 1 NC_014215.1 Chorismate + NH3 <=> Anthranilate + pyruvate + H2O and Chorismate + L-glutamine <=> Anthranilate + pyruvate + L-glutamate; anthranilate synthase component I 1344348 trpE 9284429 trpE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anthranilate synthase component I YP_003688143.1 1342816 R 754252 CDS YP_003688144.1 297626381 9284431 complement(1344345..1344779) 1 NC_014215.1 phosphoribosyl-AMP + H2O <=> 5-(5-phospho-D-ribosylaminoformimino)-1-(5- phosphoribosyl)-imidazole-4-carboxamide; phosphoribosyl-AMP cyclohydrolase 1344779 hisI2 9284431 hisI2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosyl-AMP cyclohydrolase YP_003688144.1 1344345 R 754252 CDS YP_003688145.1 297626382 9283708 1344867..1345559 1 NC_014215.1 hypothetical protein 1345559 9283708 PFREUD_11930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688145.1 1344867 D 754252 CDS YP_003688146.1 297626383 9282626 complement(1345604..1347316) 1 NC_014215.1 glutaminyl-tRNA synthetase 1347316 glnS 9282626 glnS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutaminyl-tRNA synthetase YP_003688146.1 1345604 R 754252 CDS YP_003688147.1 297626384 9283626 complement(1347338..1347961) 1 NC_014215.1 2-phospho-D-glycerate <=> 3-phospho-D-glycerate and 3-phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate; phosphoglycerate mutase 1347961 pgm2 9283626 pgm2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate mutase YP_003688147.1 1347338 R 754252 CDS YP_003688148.1 297626385 9284063 1348150..1349130 1 NC_014215.1 ABC transporter substrate-binding protein 1349130 9284063 PFREUD_11960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter substrate-binding protein YP_003688148.1 1348150 D 754252 CDS YP_003688149.1 297626386 9282627 1349137..1350090 1 NC_014215.1 ABC transporter permease 1350090 9282627 PFREUD_11970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003688149.1 1349137 D 754252 CDS YP_003688150.1 297626387 9282628 1350092..1350883 1 NC_014215.1 ABC transporter ATP-binding protein 1350883 9282628 PFREUD_11980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688150.1 1350092 D 754252 CDS YP_003688151.1 297626388 9282629 1351049..1352086 1 NC_014215.1 hypothetical protein 1352086 9282629 PFREUD_11990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688151.1 1351049 D 754252 CDS YP_003688152.1 297626389 9282630 complement(1352225..1353025) 1 NC_014215.1 LMBE-related protein 1353025 9282630 PFREUD_12000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LMBE-related protein YP_003688152.1 1352225 R 754252 CDS YP_003688153.1 297626390 9282631 1353473..1354090 1 NC_014215.1 hypothetical protein 1354090 9282631 PFREUD_12010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688153.1 1353473 D 754252 CDS YP_003688154.1 297626391 9282632 complement(1354140..1354757) 1 NC_014215.1 SUA5/yciO/yrdC family protein 1354757 9282632 PFREUD_12020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 SUA5/yciO/yrdC family protein YP_003688154.1 1354140 R 754252 CDS YP_003688155.1 297626392 9282633 complement(1354826..1355248) 1 NC_014215.1 hypothetical protein 1355248 9282633 PFREUD_12030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688155.1 1354826 R 754252 CDS YP_003688156.1 297626393 9282634 1355472..1356686 1 NC_014215.1 glycolyse : catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. PPi-PFKs are dimeric and nonallosteric . evidenced as a heat stress protein in P.freudenreichii.; pyrophosphate phosphofructokinase 1356686 pfp 9282634 pfp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyrophosphate phosphofructokinase YP_003688156.1 1355472 D 754252 CDS YP_003688157.1 297626394 9282635 complement(1357017..1357565) 1 NC_014215.1 hypothetical protein 1357565 9282635 PFREUD_12060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688157.1 1357017 R 754252 CDS YP_003688158.1 297626395 9282636 complement(1357663..1358481) 1 NC_014215.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase principal sigma factor HrdD 1358481 hrdD1 9282636 hrdD1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RNA polymerase principal sigma factor HrdD YP_003688158.1 1357663 R 754252 CDS YP_003688159.1 297626396 9283715 complement(1358590..1360458) 1 NC_014215.1 DNA primase 1360458 dnaG1 9283715 dnaG1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA primase YP_003688159.1 1358590 R 754252 CDS YP_003688160.1 297626397 9283511 1360625..1361323 1 NC_014215.1 ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine <=> ADP + 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate; phosphomethylpyrimidine kinase 1361323 tenA 9283511 tenA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphomethylpyrimidine kinase YP_003688160.1 1360625 D 754252 CDS YP_003688161.1 297626398 9284318 1361397..1361693 1 NC_014215.1 hypothetical protein 1361693 9284318 PFREUD_12100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688161.1 1361397 D 754252 CDS YP_003688162.1 297626399 9282637 1361963..1363396 1 NC_014215.1 hypothetical protein 1363396 9282637 PFREUD_12110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688162.1 1361963 D 754252 CDS YP_003688163.1 297626400 9282638 1363501..1364457 1 NC_014215.1 ADP-D-ribosyl-[dinitrogen reductase] + H2O <=> [Dinitrogen reductase] + ADP-D-ribose; ADP-ribosyl-[dinitrogen reductase] hydrolase 1364457 9282638 PFREUD_12120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ADP-ribosyl-[dinitrogen reductase] hydrolase YP_003688163.1 1363501 D 754252 CDS YP_003688164.1 297626401 9282639 1364608..1364754 1 NC_014215.1 hypothetical protein 1364754 9282639 PFREUD_12130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688164.1 1364608 D 754252 CDS YP_003688165.1 297626402 9282640 1365089..1365196 1 NC_014215.1 hypothetical protein 1365196 9282640 PFREUD_12140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688165.1 1365089 D 754252 CDS YP_003688166.1 297626403 9282642 complement(1365508..1366365) 1 NC_014215.1 Catalytic activity: trehalose 6-phosphate + H2O = trehalose + phosphate. Annotated from work of Cardoso et al, 2007 (PubMed 17185556); trehalose-phosphatase 1366365 otsB 9282642 otsB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 trehalose-phosphatase YP_003688166.1 1365508 R 754252 CDS YP_003688167.1 297626404 9283990 1366527..1368008 1 NC_014215.1 Annotated from work of Cardoso et al, 2007 (PubMed 17185556) Molecular function: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity.; trehalose-6-phosphate synthase 1368008 otsA 9283990 otsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 trehalose-6-phosphate synthase YP_003688167.1 1366527 D 754252 CDS YP_003688168.1 297626405 9283989 complement(1368267..1368776) 1 NC_014215.1 2-phospho-D-glycerate <=> 3-phospho-D-glycerate and 3-phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate; phosphoglycerate mutase 1368776 pgm 9283989 pgm Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate mutase YP_003688168.1 1368267 R 754252 CDS YP_003688169.1 297626406 9284060 1368807..1369880 1 NC_014215.1 responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate.; CbiB/CobD 1369880 cbiB/cobD 9284060 cbiB/cobD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CbiB/CobD YP_003688169.1 1368807 D 754252 CDS YP_003688170.1 297626407 9283397 1369877..1371322 1 NC_014215.1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; Cobyric acid synthase CbiP/CobQ 1371322 cbiP/cobQ 9283397 cbiP/cobQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cobyric acid synthase CbiP/CobQ YP_003688170.1 1369877 D 754252 CDS YP_003688171.1 297626408 9283408 1371319..1371921 1 NC_014215.1 Cob(I)yrinate a,c diamide + ATP <=> adenosyl cobyrinate a,c diamide + Triphosphate; cob(I)alamin adenosyltransferase 1371921 cobA2 9283408 cobA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cob(I)alamin adenosyltransferase YP_003688171.1 1371319 D 754252 CDS YP_003688172.1 297626409 9283433 1371918..1374500 1 NC_014215.1 Cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O <=> Cob(II)yrinate a,c diamide + 2 L-glutamate + 2 ADP + 2 Orthophosphate; cobyrinic acid A,C-diamide synthase CbiA 1374500 cbiA 9283433 cbiA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobyrinic acid A,C-diamide synthase CbiA YP_003688172.1 1371918 D 754252 CDS YP_003688173.1 297626410 9283396 1374497..1375168 1 NC_014215.1 adenosyl cobinamide phosphate + GTP <=> adenosine-GDP-cobinamide + Pyrophosphate; CobU Bifunctional cobalamin biosynthesis pyrophosphate enzyme 1375168 cobU 9283396 cobU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CobU Bifunctional cobalamin biosynthesis pyrophosphate enzyme YP_003688173.1 1374497 D 754252 CDS YP_003688174.1 297626411 9283438 1375128..1375949 1 NC_014215.1 Cobamide coenzyme + GMP <=> adenosine-GDP-cobinamide + alpha-Ribazole; cobalamin 5-phosphate synthase 1375949 cobS 9283438 cobS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalamin 5-phosphate synthase YP_003688174.1 1375128 D 754252 CDS YP_003688175.1 297626412 9283437 1376043..1376657 1 NC_014215.1 transcriptional regulator 1376657 cobR 9283437 cobR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688175.1 1376043 D 754252 CDS YP_003688176.1 297626413 9283436 1376654..1377466 1 NC_014215.1 hypothetical protein 1377466 9283436 PFREUD_12260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688176.1 1376654 D 754252 CDS YP_003688177.1 297626414 9282643 1377471..1379678 1 NC_014215.1 transporter 1379678 9282643 PFREUD_12270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transporter YP_003688177.1 1377471 D 754252 CDS YP_003688178.1 297626415 9282644 complement(1379651..1381081) 1 NC_014215.1 involved in tRNA maturation; ribonuclease_BN 1381081 9282644 PFREUD_12280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease_BN YP_003688178.1 1379651 R 754252 CDS YP_003688179.1 297626416 9282645 1380150..1380722 1 NC_014215.1 hypothetical protein 1380722 9282645 PFREUD_12290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688179.1 1380150 D 754252 CDS YP_003688180.1 297626417 9282646 complement(1381117..1384032) 1 NC_014215.1 glycine + Lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2 . The glycine cleavage system is composed of four proteins: P, T, L and H; glycine cleavage system protein P 1384032 gcvP 9282646 gcvP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine cleavage system protein P YP_003688180.1 1381117 R 754252 CDS YP_003688181.1 297626418 9283605 complement(1384184..1384759) 1 NC_014215.1 The MERR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporters genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements.; MerR family transcriptional regulator 1384759 9283605 PFREUD_12310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MerR family transcriptional regulator YP_003688181.1 1384184 R 754252 CDS YP_003688182.1 297626419 9282647 complement(1384940..1385401) 1 NC_014215.1 hypothetical protein 1385401 9282647 PFREUD_12320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688182.1 1384940 R 754252 CDS YP_003688183.1 297626420 9282648 complement(1385403..1386137) 1 NC_014215.1 MerR, which is found in many bacterial species mediates the mercuric-dependent induction of the mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly, as a dimer, to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site; MerR family transcriptional regulator 1386137 merR1 9282648 merR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MerR family transcriptional regulator YP_003688183.1 1385403 R 754252 CDS YP_003688184.1 297626421 9283873 complement(1386137..1386625) 1 NC_014215.1 involved in signal transduction mechanisms; forkhead-associated protein 1386625 9283873 PFREUD_12340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 forkhead-associated protein YP_003688184.1 1386137 R 754252 CDS YP_003688185.1 297626422 9282649 complement(1386791..1387174) 1 NC_014215.1 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; glycine cleavage system protein H 1387174 gcvH 9282649 gcvH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine cleavage system protein H YP_003688185.1 1386791 R 754252 CDS YP_003688186.1 297626423 9283604 complement(1387286..1388020) 1 NC_014215.1 hypothetical protein 1388020 9283604 PFREUD_12360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688186.1 1387286 R 754252 CDS YP_003688187.1 297626424 9282650 complement(1388013..1388345) 1 NC_014215.1 This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.; hypothetical protein 1388345 9282650 PFREUD_12370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688187.1 1388013 R 754252 CDS YP_003688188.1 297626425 9282651 complement(1388373..1389224) 1 NC_014215.1 hypothetical protein 1389224 9282651 PFREUD_12380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688188.1 1388373 R 754252 CDS YP_003688189.1 297626426 9282652 complement(1389221..1389898) 1 NC_014215.1 CDP-diacylglycerol + sn-glycerol 3-phosphate <=> CMP + phosphatidylglycerophosphate; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1389898 pgs1 9282652 pgs1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_003688189.1 1389221 R 754252 CDS YP_003688190.1 297626427 9284064 complement(1389938..1391083) 1 NC_014215.1 transfers one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol. transferase activity. Belongs to the glycosyltransferase 1 family.; phosphatidylinositol alpha-mannosyltransferase 1391083 pimA 9284064 pimA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphatidylinositol alpha-mannosyltransferase YP_003688190.1 1389938 R 754252 CDS YP_003688191.1 297626428 9284073 complement(1391080..1391922) 1 NC_014215.1 lipopolysaccharide core region biosynthetic process; acyltransferase 1391922 9284073 PFREUD_12410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acyltransferase YP_003688191.1 1391080 R 754252 CDS YP_003688192.1 297626429 9282653 complement(1391955..1392584) 1 NC_014215.1 CDP-diacylglycerol + sn-glycerol 3-phosphate <=> CMP + phosphatidylglycerophosphate; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1392584 pgs2 9282653 pgs2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_003688192.1 1391955 R 754252 CDS YP_003688193.1 297626430 9284065 complement(1392577..1393182) 1 NC_014215.1 HIT family protein 1393182 9284065 PFREUD_12430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 HIT family protein YP_003688193.1 1392577 R 754252 CDS YP_003688194.1 297626431 9282654 complement(1393175..1395217) 1 NC_014215.1 ATP + L-Threonine + tRNA(Thr) <=> AMP + Pyrophosphate + L-Threonyl-tRNA(Thr); threonyl-tRNA synthetase 1395217 thrS 9282654 thrS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 threonyl-tRNA synthetase YP_003688194.1 1393175 R 754252 CDS YP_003688195.1 297626432 9282655 complement(1395570..1395803) 1 NC_014215.1 hypothetical protein 1395803 9282655 PFREUD_12460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688195.1 1395570 R 754252 CDS YP_003688196.1 297626433 9282659 1396945..1397787 1 NC_014215.1 hypothetical protein 1397787 9282659 PFREUD_12500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688196.1 1396945 D 754252 CDS YP_003688197.1 297626434 9282660 complement(1397913..1398788) 1 NC_014215.1 hypothetical protein 1398788 9282660 PFREUD_12510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688197.1 1397913 R 754252 CDS YP_003688198.1 297626435 9282661 1398936..1399388 1 NC_014215.1 L-methionine + thioredoxin disulfide + H(2)O <=> L-methionine (S)-S-oxide + thioredoxin # The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress.; L-methionine (S)-S-oxide reductase 1399388 msrB 9282661 msrB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-methionine (S)-S-oxide reductase YP_003688198.1 1398936 D 754252 CDS YP_003688199.1 297626436 9283914 1399412..1399936 1 NC_014215.1 thought to be involved in oligo-nucleotide binding, with possible roles in recognition/discrimination or editing of prolyl-tRNA.; prolyl-tRNA synthetase 1399936 ybaK 9283914 ybaK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 prolyl-tRNA synthetase YP_003688199.1 1399412 D 754252 CDS YP_003688200.1 297626437 9284485 1400022..1400621 1 NC_014215.1 hypothetical protein 1400621 9284485 PFREUD_12540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688200.1 1400022 D 754252 CDS YP_003688201.1 297626438 9282662 1400618..1401955 1 NC_014215.1 This is an endoribonuclease that cleaves double-stranded RNA molecules; ribonuclease D (3-5 exonuclease) 1401955 rnd 9282662 rnd Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease D (3-5 exonuclease) YP_003688201.1 1400618 D 754252 CDS YP_003688202.1 297626439 9284190 complement(1402007..1403986) 1 NC_014215.1 pyruvate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> 1-deoxy-D-xylulose 5-phosphate + CO2; deoxyxylulose-5-phosphate synthase 1403986 dxs 9284190 dxs Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 deoxyxylulose-5-phosphate synthase YP_003688202.1 1402007 R 754252 CDS YP_003688203.1 297626440 9283530 complement(1404073..1404591) 1 NC_014215.1 hypothetical protein 1404591 9283530 PFREUD_12570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688203.1 1404073 R 754252 CDS YP_003688204.1 297626441 9282663 complement(1404753..1405055) 1 NC_014215.1 hypothetical protein 1405055 9282663 PFREUD_12580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688204.1 1404753 R 754252 CDS YP_003688205.1 297626442 9282664 complement(1405167..1407839) 1 NC_014215.1 Citrate = isocitrate. Binds 1 4Fe-4S cluster per subunit. Repressed by acnR; aconitase 1407839 acn 9282664 acn Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aconitase YP_003688205.1 1405167 R 754252 CDS YP_003688206.1 297626443 9283291 complement(1408178..1409524) 1 NC_014215.1 sugar transporter, major facilitator superfamily 1409524 9283291 PFREUD_12600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar transporter, major facilitator superfamily YP_003688206.1 1408178 R 754252 CDS YP_003688207.1 297626444 9282665 complement(1409632..1410660) 1 NC_014215.1 glutathione S-transferase 1410660 Gst 9282665 Gst Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutathione S-transferase YP_003688207.1 1409632 R 754252 CDS YP_003688208.1 297626445 9283666 1410966..1411061 1 NC_014215.1 hypothetical protein 1411061 9283666 PFREUD_12620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688208.1 1410966 D 754252 CDS YP_003688209.1 297626446 9282666 1411152..1412126 1 NC_014215.1 O3-acetyl-L-serine + H2S = L-cysteine + acetate. COFACTOR: Pyridoxal phosphate Belongs to the cysteine synthase/cystathionine beta-synthase family; cysteine synthase 1412126 cysK 9282666 cysK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cysteine synthase YP_003688209.1 1411152 D 754252 CDS YP_003688210.1 297626447 9283464 1412123..1412773 1 NC_014215.1 acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions.; acetyltransferase 1412773 9283464 PFREUD_12640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688210.1 1412123 D 754252 CDS YP_003688211.1 297626448 9284491 complement(1413865..1414125) 1 NC_014215.1 hypothetical protein 1414125 9284491 PFREUD_12670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688211.1 1413865 R 754252 CDS YP_003688212.1 297626449 9282668 complement(1414122..1415300) 1 NC_014215.1 S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing thymine; tRNA (uracil-5-)-methyltransferase 1415300 9282668 PFREUD_12680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA (uracil-5-)-methyltransferase YP_003688212.1 1414122 R 754252 CDS YP_003688213.1 297626450 9282669 complement(1415297..1417291) 1 NC_014215.1 cellular component: membrane, amino acid transporter activity; amino acid ABC transporter permease 1417291 ydaO 9282669 ydaO Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003688213.1 1415297 R 754252 CDS YP_003688214.1 297626451 9284488 1417464..1418126 1 NC_014215.1 Trk system potassium uptake protein TrkA 1418126 TrkA 9284488 TrkA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Trk system potassium uptake protein TrkA YP_003688214.1 1417464 D 754252 CDS YP_003688215.1 297626452 9284421 1418140..1418808 1 NC_014215.1 Trk system potassium uptake protein TrkA 1418808 trkA 9284421 trkA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Trk system potassium uptake protein TrkA YP_003688215.1 1418140 D 754252 CDS YP_003688216.1 297626453 9284422 complement(1418815..1419195) 1 NC_014215.1 nucleic acid-binding protein 1419195 9284422 PFREUD_12720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nucleic acid-binding protein YP_003688216.1 1418815 R 754252 CDS YP_003688217.1 297626454 9282670 complement(1419192..1420013) 1 NC_014215.1 hypothetical protein 1420013 9282670 PFREUD_12730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688217.1 1419192 R 754252 CDS YP_003688218.1 297626455 9282671 1420303..1420623 1 NC_014215.1 hypothetical protein 1420623 9282671 PFREUD_12740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688218.1 1420303 D 754252 CDS YP_003688219.1 297626456 9282672 complement(1420735..1421109) 1 NC_014215.1 hypothetical protein 1421109 9282672 PFREUD_12750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688219.1 1420735 R 754252 CDS YP_003688220.1 297626457 9282673 1421325..1422653 1 NC_014215.1 hypothetical protein 1422653 9282673 PFREUD_12760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688220.1 1421325 D 754252 CDS YP_003688221.1 297626458 9282674 complement(1422756..1423907) 1 NC_014215.1 These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars; type I phosphodiesterase / nucleotide pyrophosphatase 1423907 9282674 PFREUD_12770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 type I phosphodiesterase / nucleotide pyrophosphatase YP_003688221.1 1422756 R 754252 CDS YP_003688222.1 297626459 9282675 complement(1423911..1424504) 1 NC_014215.1 hypothetical protein 1424504 9282675 PFREUD_12780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688222.1 1423911 R 754252 CDS YP_003688223.1 297626460 9282676 1424560..1425645 1 NC_014215.1 hypothetical protein 1425645 9282676 PFREUD_12790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688223.1 1424560 D 754252 CDS YP_003688224.1 297626461 9282677 1425771..1428233 1 NC_014215.1 DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.; DNA gyrase subunit A 1428233 gyrA2 9282677 gyrA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA gyrase subunit A YP_003688224.1 1425771 D 754252 CDS YP_003688225.1 297626462 9283681 1428339..1429256 1 NC_014215.1 (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+; 2-dehydropantoate 2-reductase 1429256 panE 9283681 panE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-dehydropantoate 2-reductase YP_003688225.1 1428339 D 754252 CDS YP_003688226.1 297626463 9283995 complement(1429281..1431401) 1 NC_014215.1 DNA gyrase subunit B 1431401 gyrB1 9283995 gyrB1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA gyrase subunit B YP_003688226.1 1429281 R 754252 CDS YP_003688227.1 297626464 9283682 1431558..1431755 1 NC_014215.1 hypothetical protein 1431755 9283682 PFREUD_12830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688227.1 1431558 D 754252 CDS YP_003688228.1 297626465 9282678 1431901..1432866 1 NC_014215.1 (S)-Lactate + NAD+ <=> pyruvate + NADH + H+; L-lactate dehydrogenase 1432866 ldh2 9282678 ldh2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-lactate dehydrogenase YP_003688228.1 1431901 D 754252 CDS YP_003688229.1 297626466 9283814 complement(1432954..1434483) 1 NC_014215.1 RNA polymerase principal sigma factor HrdB 1434483 hrdB 9283814 hrdB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RNA polymerase principal sigma factor HrdB YP_003688229.1 1432954 R 754252 CDS YP_003688230.1 297626467 9283714 1434842..1435771 1 NC_014215.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.; RNA polymerase principal sigma factor HrdD 1435771 hrdD2 9283714 hrdD2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RNA polymerase principal sigma factor HrdD YP_003688230.1 1434842 D 754252 CDS YP_003688231.1 297626468 9283807 1437161..1437640 1 NC_014215.1 ABC transporter 1437640 9283807 PFREUD_12890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003688231.1 1437161 D 754252 CDS YP_003688232.1 297626469 9282679 1437510..1438502 1 NC_014215.1 ABC transporter 1438502 9282679 PFREUD_12900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003688232.1 1437510 D 754252 CDS YP_003688233.1 297626470 9282680 complement(1438515..1439390) 1 NC_014215.1 carboxylic ester hydrolase 1439390 pf1637 9282680 pf1637 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003688233.1 1438515 R 754252 CDS YP_003688234.1 297626471 9284033 complement(1439498..1443466) 1 NC_014215.1 ATP-dependent helicase HrpA 1443466 hrpA2 9284033 hrpA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent helicase HrpA YP_003688234.1 1439498 R 754252 CDS YP_003688235.1 297626472 9283718 complement(1443529..1444416) 1 NC_014215.1 transposase 1444416 tnpB 9283718 tnpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688235.1 1443529 R 754252 CDS YP_003688236.1 297626473 9284398 complement(1444449..1444793) 1 NC_014215.1 transposase IS3/IS911 1444793 TnpD 9284398 TnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003688236.1 1444449 R 754252 CDS YP_003688237.1 297626474 9284409 complement(1444957..1447587) 1 NC_014215.1 phosphoketolase pyrophosphate 1447587 phk 9284409 phk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoketolase pyrophosphate YP_003688237.1 1444957 R 754252 CDS YP_003688238.1 297626475 9284069 complement(1447647..1448582) 1 NC_014215.1 permease 1448582 9284069 PFREUD_12940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 permease YP_003688238.1 1447647 R 754252 CDS YP_003688240.1 297626477 9282682 1448785..1449738 1 NC_014215.1 Zeng X., Saxild H.H.; dentification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis J. Bacteriol. 181:1719-1727(1999).; DeoR family transcriptional regulator 1449738 deoR2 9282682 deoR2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DeoR family transcriptional regulator YP_003688240.1 1448785 D 754252 CDS YP_003688241.1 297626478 9283488 complement(1449821..1451212) 1 NC_014215.1 Composed of a catalytic glpA/B dimer and of glpC. electron transfer protein; may also function as the membrane anchor for the glpAB dimer; anaerobic glycerol-3-phosphate dehydrogenase subunit C 1451212 glpC 9283488 glpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic glycerol-3-phosphate dehydrogenase subunit C YP_003688241.1 1449821 R 754252 CDS YP_003688242.1 297626479 9283629 complement(1451209..1452519) 1 NC_014215.1 Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor.; anaerobic glycerol-3-phosphate dehydrogenase subunit B 1452519 glpB 9283629 glpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_003688242.1 1451209 R 754252 CDS YP_003688243.1 297626480 9283628 complement(1452516..1454144) 1 NC_014215.1 anaerobic glycerol-3-phosphate dehydrogenase subunit A 1454144 glpA 9283628 glpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic glycerol-3-phosphate dehydrogenase subunit A YP_003688243.1 1452516 R 754252 CDS YP_003688244.1 297626481 9283627 1454354..1455277 1 NC_014215.1 carboxylic ester hydrolase 1455277 pf379 9283627 pf379 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003688244.1 1454354 D 754252 CDS YP_003688245.1 297626482 9284047 complement(1455386..1458277) 1 NC_014215.1 2 prime-deoxyribonucleoside diphosphate + Oxidized thioredoxin + H2O <=> ribonucleoside diphosphate + thioredoxin; vitamin B12-dependent ribonucleotide reductase 1458277 nrdJ 9284047 nrdJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 vitamin B12-dependent ribonucleotide reductase YP_003688245.1 1455386 R 754252 CDS YP_003688246.1 297626483 9283959 complement(1458463..1458960) 1 NC_014215.1 repress transcription of PF # 2791; NrdR family transcriptional regulator 1458960 nrdR 9283959 nrdR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NrdR family transcriptional regulator YP_003688246.1 1458463 R 754252 CDS YP_003688247.1 297626484 9283960 complement(1459295..1460026) 1 NC_014215.1 hypothetical protein 1460026 9283960 PFREUD_13030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688247.1 1459295 R 754252 CDS YP_003688248.1 297626485 9282683 1460350..1461192 1 NC_014215.1 Represses genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of ss DNA, recA interacts with lexA causing autocatalytic cleavage which disrupts the DNA-binding part of lexA, leading to derepression of the SOS regulon and eventually DNA repair. Hydrolysis of Ala-|-Gly bond in repressor lexA. Belongs to the peptidase S24 family. Homodimer.; peptidase S24 1461192 lexA 9282683 lexA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase S24 YP_003688248.1 1460350 D 754252 CDS YP_003688249.1 297626486 9283824 complement(1461196..1463313) 1 NC_014215.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent helicase 1463313 dinG 9283824 dinG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent helicase YP_003688249.1 1461196 R 754252 CDS YP_003688250.1 297626487 9283499 complement(1463426..1464847) 1 NC_014215.1 . Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane. Iron transport may be ATP dependent; FeoB, Ferrous iron transport protein B 1464847 9283499 PFREUD_13060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FeoB, Ferrous iron transport protein B YP_003688250.1 1463426 R 754252 CDS YP_003688251.1 297626488 9282684 complement(1464906..1465739) 1 NC_014215.1 LL-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate; diaminopimelate epimerase 1465739 dapF 9282684 dapF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 diaminopimelate epimerase YP_003688251.1 1464906 R 754252 CDS YP_003688252.1 297626489 9283480 complement(1465763..1466749) 1 NC_014215.1 Isopentenyl diphosphate + tRNA <=> Pyrophosphate + tRNA containing 6-isopentenyladenosine; tRNA isopentenyltransferase 1466749 miaA 9283480 miaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA isopentenyltransferase YP_003688252.1 1465763 R 754252 CDS YP_003688253.1 297626490 9283885 complement(1466746..1468260) 1 NC_014215.1 2-methylthioadenine synthetase 1468260 miaB1 9283885 miaB1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-methylthioadenine synthetase YP_003688253.1 1466746 R 754252 CDS YP_003688254.1 297626491 9283886 1468364..1469179 1 NC_014215.1 ATP-binding protein of ABC transporter for glutamate 1469179 gluA 9283886 gluA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-binding protein of ABC transporter for glutamate YP_003688254.1 1468364 D 754252 CDS YP_003688255.1 297626492 9283640 complement(1469189..1470724) 1 NC_014215.1 metal dependent phosphohydrolase 1470724 9283640 PFREUD_13110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal dependent phosphohydrolase YP_003688255.1 1469189 R 754252 CDS YP_003688256.1 297626493 9282685 complement(1470886..1471500) 1 NC_014215.1 RecX is a putative bacterial regulatory protein. The gene encoding RecX is found downstream of recA, and is thought to interact with the RecA protein.; RecX family transcriptional regulator 1471500 recX 9282685 recX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RecX family transcriptional regulator YP_003688256.1 1470886 R 754252 CDS YP_003688257.1 297626494 9284170 complement(1471503..1472621) 1 NC_014215.1 recombinase A 1472621 recA 9284170 recA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 recombinase A YP_003688257.1 1471503 R 754252 CDS YP_003688258.1 297626495 9284161 1472903..1473097 1 NC_014215.1 hypothetical protein 1473097 9284161 PFREUD_13140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688258.1 1472903 D 754252 CDS YP_003688259.1 297626496 9282686 1473201..1477880 1 NC_014215.1 ATP-dependent helicase 1477880 9282686 PFREUD_13150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent helicase YP_003688259.1 1473201 D 754252 CDS YP_003688260.1 297626497 9282687 complement(1478102..1478395) 1 NC_014215.1 Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.; XRE family transcriptional regulator 1478395 9282687 PFREUD_13160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 XRE family transcriptional regulator YP_003688260.1 1478102 R 754252 CDS YP_003688261.1 297626498 9282688 complement(1478346..1478465) 1 NC_014215.1 hypothetical protein 1478465 9282688 PFREUD_13170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688261.1 1478346 R 754252 CDS YP_003688262.1 297626499 9282689 complement(1478575..1479078) 1 NC_014215.1 CinA, Competence-damaged protein 1479078 cinA 9282689 cinA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CinA, Competence-damaged protein YP_003688262.1 1478575 R 754252 CDS YP_003688263.1 297626500 9283417 complement(1479071..1479724) 1 NC_014215.1 CDP-diacylglycerol + sn-glycerol 3-phosphate <=> CMP + phosphatidylglycerophosphate; phosphatidylglycerophosphate synthase 1479724 9283417 PFREUD_13190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphatidylglycerophosphate synthase YP_003688263.1 1479071 R 754252 CDS YP_003688264.1 297626501 9282690 complement(1479729..1481162) 1 NC_014215.1 2-methylthioadenine synthetase 1481162 miaB2 9282690 miaB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-methylthioadenine synthetase YP_003688264.1 1479729 R 754252 CDS YP_003688265.1 297626502 9283887 complement(1481242..1483725) 1 NC_014215.1 DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it. protein located at the septum; DNA translocase FtsK 1483725 ftsK 9283887 ftsK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA translocase FtsK YP_003688265.1 1481242 R 754252 CDS YP_003688266.1 297626503 9283579 complement(1483797..1484780) 1 NC_014215.1 ATP + Thiamin monophosphate <=> ADP + Thiamin diphosphate; thiamine monophosphate kinase 1484780 thiL 9283579 thiL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine monophosphate kinase YP_003688266.1 1483797 R 754252 CDS YP_003688267.1 297626504 9284334 complement(1484791..1485525) 1 NC_014215.1 transcriptional regulator 1485525 9284334 PFREUD_13230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688267.1 1484791 R 754252 CDS YP_003688268.1 297626505 9282691 1485629..1486630 1 NC_014215.1 hypothetical protein 1486630 9282691 PFREUD_13240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688268.1 1485629 D 754252 CDS YP_003688269.1 297626506 9282692 complement(1486669..1487796) 1 NC_014215.1 Involvedin the synthesis of a cell-wall peptide . ATP + 2 D-alanine <=> ADP + Orthophosphate + D-Alanyl-D-alanine; D-alanine--D-alanine ligase 1487796 ddlA 9282692 ddlA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-alanine--D-alanine ligase YP_003688269.1 1486669 R 754252 CDS YP_003688270.1 297626507 9283484 complement(1487870..1488664) 1 NC_014215.1 1-acylglycerol-3-phosphate O-acyltransferase 1488664 plsC1 9283484 plsC1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1-acylglycerol-3-phosphate O-acyltransferase YP_003688270.1 1487870 R 754252 CDS YP_003688271.1 297626508 9284081 complement(1488805..1489401) 1 NC_014215.1 * (2S)-2-Isopropylmalate <=> 2-Isopropylmaleate + H2O; 3-isopropylmalate dehydratase small subunit 1489401 leuD 9284081 leuD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-isopropylmalate dehydratase small subunit YP_003688271.1 1488805 R 754252 CDS YP_003688272.1 297626509 9283822 complement(1489415..1490815) 1 NC_014215.1 (2S)-2-Isopropylmalate <=> 2-Isopropylmaleate + H2O; 3-isopropylmalate dehydratase large subunit 1490815 leuC 9283822 leuC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-isopropylmalate dehydratase large subunit YP_003688272.1 1489415 R 754252 CDS YP_003688273.1 297626510 9283821 1490868..1491596 1 NC_014215.1 This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family.; IclR family transcriptional regulator 1491596 iclR 9283821 iclR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 IclR family transcriptional regulator YP_003688273.1 1490868 D 754252 CDS YP_003688274.1 297626511 9282694 complement(1491998..1493092) 1 NC_014215.1 membrane protease 1493092 9282694 PFREUD_13320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 membrane protease YP_003688274.1 1491998 R 754252 CDS YP_003688275.1 297626512 9282695 complement(1493100..1493945) 1 NC_014215.1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 1493945 PPA1366 9282695 PPA1366 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_003688275.1 1493100 R 754252 CDS YP_003688276.1 297626513 9284100 complement(1494005..1495603) 1 NC_014215.1 (2S)-2-Isopropylmalate + CoA <=> acetyl-CoA + 3-methyl-2-oxobutanoic acid + H2O; 2-isopropylmalate synthase 1495603 leuA2 9284100 leuA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-isopropylmalate synthase YP_003688276.1 1494005 R 754252 CDS YP_003688277.1 297626514 9283819 complement(1495635..1496720) 1 NC_014215.1 Catalyzes the first reaction in the catabolism of the branched subunit amino acids leucine, isoleucine, and valine. pyridoxal-phosphate dependent enzymes; branched-subunit amino acid aminotransferase 1496720 ilvE 9283819 ilvE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 branched-subunit amino acid aminotransferase YP_003688277.1 1495635 R 754252 CDS YP_003688278.1 297626515 9283741 1496886..1497950 1 NC_014215.1 (2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+; 3-isopropylmalate dehydrogenase 1497950 leuB 9283741 leuB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-isopropylmalate dehydrogenase YP_003688278.1 1496886 D 754252 CDS YP_003688279.1 297626516 9283820 1498238..1498825 1 NC_014215.1 hypothetical protein 1498825 9283820 PFREUD_13370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688279.1 1498238 D 754252 CDS YP_003688280.1 297626517 9282696 1498807..1499670 1 NC_014215.1 hypothetical protein 1499670 9282696 PFREUD_13380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688280.1 1498807 D 754252 CDS YP_003688281.1 297626518 9282697 complement(1499829..1500860) 1 NC_014215.1 2-acetolactate + NADPH + H+ <=> 2,3-dihydroxy-3-methylbutanoate + NADP+; ketol-acid reductoisomerase 1500860 ilvC 9282697 ilvC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ketol-acid reductoisomerase YP_003688281.1 1499829 R 754252 CDS YP_003688282.1 297626519 9283739 complement(1500905..1501411) 1 NC_014215.1 2-acetolactate + CO2 <=> 2 pyruvate - amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.; acetolactate synthase small subunit 1501411 ilvN 9283739 ilvN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetolactate synthase small subunit YP_003688282.1 1500905 R 754252 CDS YP_003688283.1 297626520 9283742 complement(1501429..1503189) 1 NC_014215.1 2-acetolactate + CO2 <=> 2 pyruvate - amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.; acetolactate synthase large subunit 1503189 ilvB 9283742 ilvB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetolactate synthase large subunit YP_003688283.1 1501429 R 754252 CDS YP_003688284.1 297626521 9283738 complement(1503488..1504690) 1 NC_014215.1 hypothetical protein 1504690 9283738 PFREUD_13420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688284.1 1503488 R 754252 CDS YP_003688285.1 297626522 9282698 complement(1504698..1505462) 1 NC_014215.1 imidazole glycerol phosphate synthase subunit HisF 1505462 hisF 9282698 hisF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 imidazole glycerol phosphate synthase subunit HisF YP_003688285.1 1504698 R 754252 CDS YP_003688286.1 297626523 9283705 1505547..1506563 1 NC_014215.1 aldo/keto reductase 1506563 9283705 PFREUD_13440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aldo/keto reductase YP_003688286.1 1505547 D 754252 CDS YP_003688287.1 297626524 9282699 complement(1506678..1507007) 1 NC_014215.1 antibiotic biosynthesis monooxygenase 1507007 9282699 PFREUD_13450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 antibiotic biosynthesis monooxygenase YP_003688287.1 1506678 R 754252 CDS YP_003688288.1 297626525 9282700 complement(1507067..1509868) 1 NC_014215.1 Superfamily II RNA helicase 1509868 9282700 PFREUD_13460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Superfamily II RNA helicase YP_003688288.1 1507067 R 754252 CDS YP_003688289.1 297626526 9282701 1510004..1510861 1 NC_014215.1 Cof protein:HAD-superfamily hydrolase subfamily IIB 1510861 cof2 9282701 cof2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cof protein:HAD-superfamily hydrolase subfamily IIB YP_003688289.1 1510004 D 754252 CDS YP_003688290.1 297626527 9283441 complement(1510902..1511081) 1 NC_014215.1 hypothetical protein 1511081 9283441 PFREUD_13480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688290.1 1510902 R 754252 CDS YP_003688291.1 297626528 9282702 complement(1511118..1512083) 1 NC_014215.1 transposase 1512083 tnpA 9282702 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688291.1 1511118 R 754252 CDS YP_003688292.1 297626529 9284374 complement(1512484..1513359) 1 NC_014215.1 hypothetical protein 1513359 9284374 PFREUD_13490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688292.1 1512484 R 754252 CDS YP_003688294.1 297626531 9282704 complement(1513375..1514247) 1 NC_014215.1 Required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. This sec-independent pathway is termed TAT for twin-arginine translocation system. This system mainly transports proteins with bound cofactors that require folding prior to export; Sec-independent protein translocase protein TatC 1514247 tatC 9282704 tatC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sec-independent protein translocase protein TatC YP_003688294.1 1513375 R 754252 CDS YP_003688295.1 297626532 9284316 complement(1514266..1514574) 1 NC_014215.1 transmembran, Members of this family in E.coli are involved in export of redox proteins with a twin arginin leader motif.; Redox protein export 1514574 9284316 PFREUD_13520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Redox protein export YP_003688295.1 1514266 R 754252 CDS YP_003688296.1 297626533 9282705 complement(1514676..1515635) 1 NC_014215.1 Regulatory protein 1515635 9282705 PFREUD_13530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Regulatory protein YP_003688296.1 1514676 R 754252 CDS YP_003688297.1 297626534 9282706 complement(1515622..1516590) 1 NC_014215.1 DeoR family transcriptional regulator 1516590 9282706 PFREUD_13540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DeoR family transcriptional regulator YP_003688297.1 1515622 R 754252 CDS YP_003688298.1 297626535 9282707 1516659..1517618 1 NC_014215.1 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; glutamyl-Q tRNA(Asp) synthetase 1517618 gluQ 9282707 gluQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamyl-Q tRNA(Asp) synthetase YP_003688298.1 1516659 D 754252 CDS YP_003688299.1 297626536 9283641 complement(1517761..1518825) 1 NC_014215.1 Molecular function: peptidyl-prolyl cis-trans isomerase activity, Biological process: protein folding; peptidyl-prolyl cis-trans isomerase 1518825 9283641 PFREUD_13560 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidyl-prolyl cis-trans isomerase YP_003688299.1 1517761 R 754252 CDS YP_003688300.1 297626537 9282708 complement(1518905..1519552) 1 NC_014215.1 Molecular function: isomerase activity, Biological process: protein folding; FKBP-type peptidylprolyl isomerase 1519552 9282708 PFREUD_13570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FKBP-type peptidylprolyl isomerase YP_003688300.1 1518905 R 754252 CDS YP_003688301.1 297626538 9282709 complement(1519612..1520439) 1 NC_014215.1 RNA uridine = RNA pseudouridine.; pseudouridine synthase 1520439 rluB 9282709 rluB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pseudouridine synthase YP_003688301.1 1519612 R 754252 CDS YP_003688302.1 297626539 9284184 complement(1520387..1521064) 1 NC_014215.1 This family of conserved bacterial proteins are thought to possibly be helix-turn-helix type transcriptional regulators; transcriptional regulator 1521064 9284184 PFREUD_13590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688302.1 1520387 R 754252 CDS YP_003688303.1 297626540 9282710 complement(1521139..1522068) 1 NC_014215.1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing smc and scpB that pull DNA away from mid-cell into both cell halves; segregation and condensation protein A 1522068 scpA 9282710 scpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 segregation and condensation protein A YP_003688303.1 1521139 R 754252 CDS YP_003688304.1 297626541 9284262 complement(1522034..1522309) 1 NC_014215.1 hypothetical protein 1522309 9284262 PFREUD_13610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688304.1 1522034 R 754252 CDS YP_003688305.1 297626542 9282711 complement(1522294..1523190) 1 NC_014215.1 ATPase 1523190 9282711 PFREUD_13620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase YP_003688305.1 1522294 R 754252 CDS YP_003688306.1 297626543 9282712 complement(1523311..1524306) 1 NC_014215.1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids; site-specific recombinase 1524306 xerD 9282712 xerD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 site-specific recombinase YP_003688306.1 1523311 R 754252 CDS YP_003688307.1 297626544 9284478 complement(1524299..1524961) 1 NC_014215.1 ADP-ribose + H2O <=> AMP + D-ribose 5-phosphate; ADP-ribose pyrophosphatase 1524961 nudF 9284478 nudF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ADP-ribose pyrophosphatase YP_003688307.1 1524299 R 754252 CDS YP_003688308.1 297626545 9283962 complement(1524954..1526708) 1 NC_014215.1 ATP + UTP + NH3 <=> ADP + Orthophosphate + CTP ATP + UTP + L-glutamine + H2O <=> ADP + Orthophosphate + CTP + L-glutamate; CTP synthase 1526708 pyrG 9283962 pyrG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CTP synthase YP_003688308.1 1524954 R 754252 CDS YP_003688309.1 297626546 9284157 complement(1526795..1528486) 1 NC_014215.1 ABC_RecN, RecN ATPase involved in DNA repair; DNA repair protein 1528486 recN 9284157 recN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA repair protein YP_003688309.1 1526795 R 754252 CDS YP_003688310.1 297626547 9284167 complement(1528480..1529403) 1 NC_014215.1 inorganic polyphosphate/ATP-NAD kinase 1529403 ppnK 9284167 ppnK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inorganic polyphosphate/ATP-NAD kinase YP_003688310.1 1528480 R 754252 CDS YP_003688311.1 297626548 9284111 complement(1529468..1529707) 1 NC_014215.1 hypothetical protein 1529707 9284111 PFREUD_13680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688311.1 1529468 R 754252 CDS YP_003688312.1 297626549 9282713 complement(1529780..1530340) 1 NC_014215.1 cobalt permease 1530340 9282713 PFREUD_13690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt permease YP_003688312.1 1529780 R 754252 CDS YP_003688314.1 297626551 9282715 complement(1530384..1531112) 1 NC_014215.1 ABC transporter ATPase 1531112 9282715 PFREUD_13710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATPase YP_003688314.1 1530384 R 754252 CDS YP_003688315.1 297626552 9282716 complement(1531126..1531755) 1 NC_014215.1 BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is involved in this process, however the exact function of the protein is unknown.; BioY family protein. membrane protein 1531755 9282716 PFREUD_13720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 BioY family protein. membrane protein YP_003688315.1 1531126 R 754252 CDS YP_003688316.1 297626553 9282717 complement(1531944..1532975) 1 NC_014215.1 sugar phosphatases of the HAD superfamily; phosphatase 1532975 nagD 9282717 nagD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphatase YP_003688316.1 1531944 R 754252 CDS YP_003688317.1 297626554 9283941 complement(1532972..1533997) 1 NC_014215.1 hypothetical protein 1533997 9283941 PFREUD_13740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688317.1 1532972 R 754252 CDS YP_003688318.1 297626555 9282718 complement(1534072..1534812) 1 NC_014215.1 hypothetical protein 1534812 9282718 PFREUD_13760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688318.1 1534072 R 754252 CDS YP_003688319.1 297626556 9282719 complement(1541011..1542279) 1 NC_014215.1 tyrosyl-tRNA synthetase 1542279 tyrS 9282719 tyrS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tyrosyl-tRNA synthetase YP_003688319.1 1541011 R 754252 CDS YP_003688320.1 297626557 9284447 complement(1542407..1543765) 1 NC_014215.1 N-(L-arginino)succinate <=> Fumarate + L-arginine; argininosuccinate lyase 1543765 argH 9284447 argH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 argininosuccinate lyase YP_003688320.1 1542407 R 754252 CDS YP_003688321.1 297626558 9283333 complement(1543832..1544386) 1 NC_014215.1 arginine repressor ArgR 1544386 argR 9283333 argR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arginine repressor ArgR YP_003688321.1 1543832 R 754252 CDS YP_003688322.1 297626559 9283336 complement(1544383..1545606) 1 NC_014215.1 N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. cofactor : Pyridoxal phosphate; acetylornithine aminotransferase 1545606 argD 9283336 argD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetylornithine aminotransferase YP_003688322.1 1544383 R 754252 CDS YP_003688323.1 297626560 9283330 complement(1545599..1546510) 1 NC_014215.1 ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1546510 argB 9283330 argB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetylglutamate kinase YP_003688323.1 1545599 R 754252 CDS YP_003688324.1 297626561 9283328 complement(1546507..1547658) 1 NC_014215.1 glutamate N-acetyltransferase 1547658 ArgJ 9283328 ArgJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate N-acetyltransferase YP_003688324.1 1546507 R 754252 CDS YP_003688325.1 297626562 9283334 complement(1547655..1548686) 1 NC_014215.1 N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.; N-acetyl-gamma-glutamyl-phosphate reductase 1548686 argC 9283334 argC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 N-acetyl-gamma-glutamyl-phosphate reductase YP_003688325.1 1547655 R 754252 CDS YP_003688326.1 297626563 9283329 1548851..1550065 1 NC_014215.1 aspartate aminotransferase 1550065 got 9283329 got Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate aminotransferase YP_003688326.1 1548851 D 754252 CDS YP_003688327.1 297626564 9283654 complement(1550193..1552721) 1 NC_014215.1 ATP + L-Phenylalanine + tRNA(Phe) <=> AMP + Pyrophosphate + L-Phenylalanyl-tRNA(Phe); phenylalanyl-tRNA synthetase subunit beta 1552721 pheT 9283654 pheT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phenylalanyl-tRNA synthetase subunit beta YP_003688327.1 1550193 R 754252 CDS YP_003688328.1 297626565 9284068 complement(1552718..1553812) 1 NC_014215.1 phenylalanyl-tRNA synthetase subunit alpha 1553812 pheS 9284068 pheS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phenylalanyl-tRNA synthetase subunit alpha YP_003688328.1 1552718 R 754252 CDS YP_003688329.1 297626566 9284067 complement(1553968..1554144) 1 NC_014215.1 hypothetical protein 1554144 9284067 PFREUD_14030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688329.1 1553968 R 754252 CDS YP_003688330.1 297626567 9282720 complement(1554144..1555004) 1 NC_014215.1 rRNA methylase 1555004 spoU1 9282720 spoU1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 rRNA methylase YP_003688330.1 1554144 R 754252 CDS YP_003688331.1 297626568 9284292 complement(1555015..1555386) 1 NC_014215.1 50S ribosomal protein L20 1555386 rplT 9284292 rplT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L20 YP_003688331.1 1555015 R 754252 CDS YP_003688332.1 297626569 9284216 complement(1555432..1555626) 1 NC_014215.1 50S ribosomal protein L35 1555626 rpmI 9284216 rpmI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L35 YP_003688332.1 1555432 R 754252 CDS YP_003688333.1 297626570 9284228 complement(1555694..1556407) 1 NC_014215.1 translation initiation factor IF-3 1556407 infC 9284228 infC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 translation initiation factor IF-3 YP_003688333.1 1555694 R 754252 CDS YP_003688334.1 297626571 9283746 complement(1556453..1556614) 1 NC_014215.1 hypothetical protein 1556614 9283746 PFREUD_14080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688334.1 1556453 R 754252 CDS YP_003688335.1 297626572 9282721 1556728..1557210 1 NC_014215.1 hypothetical protein 1557210 9282721 PFREUD_14090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688335.1 1556728 D 754252 CDS YP_003688336.1 297626573 9282722 complement(1557274..1558137) 1 NC_014215.1 phosphoribosyl-ATP + Pyrophosphate <=> ATP + 5-phospho-alpha-D-ribose 1-diphosphate; ATP phosphoribosyltransferase 1558137 hisG 9282722 hisG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP phosphoribosyltransferase YP_003688336.1 1557274 R 754252 CDS YP_003688337.1 297626574 9283706 complement(1558204..1558470) 1 NC_014215.1 phosphoribosyl-ATP + H2O <=> phosphoribosyl-AMP + Pyrophosphate; phosphoribosyl-ATP pyrophosphohydrolase 1558470 hisE 9283706 hisE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoribosyl-ATP pyrophosphohydrolase YP_003688337.1 1558204 R 754252 CDS YP_003688338.1 297626575 9283704 1558643..1560793 1 NC_014215.1 FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes. It only efficiently degrades proteins that have a low thermodynamic stability In Oenococcus oeni FtsH is involved in protection against environmental stress, and shows increased expression under heat or osmotic stress.; protein FtsH 1560793 9283704 PFREUD_14120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein FtsH YP_003688338.1 1558643 D 754252 CDS YP_003688339.1 297626576 9282723 complement(1560903..1562159) 1 NC_014215.1 ATP + L-cysteine + tRNA(Cys) <=> AMP + Pyrophosphate + L-Cysteinyl-tRNA(Cys); cysteinyl-tRNA synthetase 1562159 cysS1 9282723 cysS1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cysteinyl-tRNA synthetase YP_003688339.1 1560903 R 754252 CDS YP_003688340.1 297626577 9283466 1562226..1563215 1 NC_014215.1 oxidoreductase 1563215 9283466 PFREUD_14140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 oxidoreductase YP_003688340.1 1562226 D 754252 CDS YP_003688341.1 297626578 9282724 complement(1563233..1563484) 1 NC_014215.1 hypothetical protein 1563484 9282724 PFREUD_14150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688341.1 1563233 R 754252 CDS YP_003688342.1 297626579 9282726 1564163..1564327 1 NC_014215.1 hypothetical protein 1564327 9282726 PFREUD_14170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688342.1 1564163 D 754252 CDS YP_003688343.1 297626580 9282727 1564389..1564709 1 NC_014215.1 hypothetical protein 1564709 9282727 PFREUD_14180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688343.1 1564389 D 754252 CDS YP_003688344.1 297626581 9282728 1564756..1565253 1 NC_014215.1 hypothetical protein 1565253 9282728 PFREUD_14190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688344.1 1564756 D 754252 CDS YP_003688345.1 297626582 9282729 1565768..1566604 1 NC_014215.1 UDP diphosphate + H2O <=> UDP phosphate + Orthophosphate; UDP-diphosphatase 1566604 uppP 9282729 uppP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-diphosphatase YP_003688345.1 1565768 D 754252 CDS YP_003688346.1 297626583 9284458 complement(1566675..1567061) 1 NC_014215.1 hypothetical protein 1567061 9284458 PFREUD_14210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688346.1 1566675 R 754252 CDS YP_003688347.1 297626584 9282730 complement(1567064..1568554) 1 NC_014215.1 L-serine + Indoleglycerol phosphate <=> L-tryptophan + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal + H2O. The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.; tryptophan synthase subunit beta 1568554 trpB2 9282730 trpB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tryptophan synthase subunit beta YP_003688347.1 1567064 R 754252 CDS YP_003688348.1 297626585 9284428 complement(1568547..1569707) 1 NC_014215.1 DNA mediated transformation; DNA processing / uptake protein 1569707 dprA 9284428 dprA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA processing / uptake protein YP_003688348.1 1568547 R 754252 CDS YP_003688349.1 297626586 9283521 complement(1569704..1571218) 1 NC_014215.1 Magnesium-chelatase is a three-component enzyme that catalyses the insertion of Mg2+ into protoporphyrin IX; Magnesium chelatase, subunit ChlI 1571218 chlI 9283521 chlI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Magnesium chelatase, subunit ChlI YP_003688349.1 1569704 R 754252 CDS YP_003688350.1 297626587 9283416 complement(1571239..1571601) 1 NC_014215.1 endonuclease 1571601 9283416 PFREUD_14250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 endonuclease YP_003688350.1 1571239 R 754252 CDS YP_003688351.1 297626588 9282731 complement(1571755..1572069) 1 NC_014215.1 hypothetical protein 1572069 9282731 PFREUD_14260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688351.1 1571755 R 754252 CDS YP_003688352.1 297626589 9282732 complement(1572066..1572701) 1 NC_014215.1 Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Endonucleolytic cleavage to 5-phosphomonoester. Manganese or magnesium as cofactor; ribonuclease HII 1572701 rnhB 9282732 rnhB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease HII YP_003688352.1 1572066 R 754252 CDS YP_003688353.1 297626590 9284192 complement(1572707..1573456) 1 NC_014215.1 Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; Signal peptidase I 1573456 lepB 9284192 lepB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Signal peptidase I YP_003688353.1 1572707 R 754252 CDS YP_003688354.1 297626591 9283817 complement(1573543..1573899) 1 NC_014215.1 highly similar to SwissProt entry RL19_PROAC from Propionibacterium acnes; 50S ribosomal protein L19 1573899 rplS 9283817 rplS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L19 YP_003688354.1 1573543 R 754252 CDS YP_003688355.1 297626592 9284215 complement(1574173..1574937) 1 NC_014215.1 succinate + acceptor <=> fumarate + reduced acceptor; succinate dehydrogenase 1574937 sdhB3 9284215 sdhB3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 succinate dehydrogenase YP_003688355.1 1574173 R 754252 CDS YP_003688356.1 297626593 9284268 complement(1574934..1576955) 1 NC_014215.1 succinate + FAD <=> FADH2 + Fumarate; succinate dehydrogenase flavoprotein subunit 1576955 sdhA3 9284268 sdhA3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 succinate dehydrogenase flavoprotein subunit YP_003688356.1 1574934 R 754252 CDS YP_003688357.1 297626594 9284266 complement(1576952..1577695) 1 NC_014215.1 succinate + Acceptor <=> Fumarate + Reduced acceptor; succinate dehydrogenase cytochrome B-558 subunit 1577695 sdhC2 9284266 sdhC2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 succinate dehydrogenase cytochrome B-558 subunit YP_003688357.1 1576952 R 754252 CDS YP_003688358.1 297626595 9284270 1577811..1578509 1 NC_014215.1 recombinant protein active on 1- naphthyl actetate and 1- naphthyl propionate; carboxylic ester hydrolase 1578509 pf169 9284270 pf169 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003688358.1 1577811 D 754252 CDS YP_003688359.1 297626596 9284035 complement(1578517..1579311) 1 NC_014215.1 S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine; tRNA (guanine-N1-)-methyltransferase / S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase 1579311 trmD 9284035 trmD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA (guanine-N1-)-methyltransferase / S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase YP_003688359.1 1578517 R 754252 CDS YP_003688360.1 297626597 9284424 complement(1579308..1579859) 1 NC_014215.1 16S rRNA processing protein 1579859 rimM 9284424 rimM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 16S rRNA processing protein YP_003688360.1 1579308 R 754252 CDS YP_003688361.1 297626598 9284182 complement(1579868..1580122) 1 NC_014215.1 hypothetical protein 1580122 9284182 PFREUD_14360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688361.1 1579868 R 754252 CDS YP_003688362.1 297626599 9282733 complement(1580125..1580616) 1 NC_014215.1 30S ribosomal protein S16 1580616 rpsP 9282733 rpsP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S16 YP_003688362.1 1580125 R 754252 CDS YP_003688363.1 297626600 9284249 complement(1580794..1581903) 1 NC_014215.1 metallo-dependent hydrolases, subgroup A 1581903 9284249 PFREUD_14380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metallo-dependent hydrolases, subgroup A YP_003688363.1 1580794 R 754252 CDS YP_003688364.1 297626601 9282734 complement(1581917..1583488) 1 NC_014215.1 SRP, The signal recognition particle (SRP) mediates the transport to or across the plasma membrane. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR).; GTP binding signal recognition particle protein 1583488 ffh 9282734 ffh Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP binding signal recognition particle protein YP_003688364.1 1581917 R 754252 CDS YP_003688365.1 297626602 9283554 complement(1583615..1584769) 1 NC_014215.1 signal recognition particle receptor alpha subunit (docking protein), an integral membrane GTP-binding protein which ensures, in conjunction with SRP, the correct targeting of nascent secretory proteins; Signal recognition particle receptor 1584769 ftsY 9283554 ftsY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Signal recognition particle receptor YP_003688365.1 1583615 R 754252 CDS YP_003688366.1 297626603 9283584 complement(1584861..1585058) 1 NC_014215.1 hypothetical protein 1585058 9283584 PFREUD_14410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688366.1 1584861 R 754252 CDS YP_003688367.1 297626604 9282735 complement(1585140..1588685) 1 NC_014215.1 Plays an important role in chromosome structure and partitioning. Essential for chromosome partition; chromosome partition protein Smc 1588685 smc 9282735 smc Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chromosome partition protein Smc YP_003688367.1 1585140 R 754252 CDS YP_003688368.1 297626605 9284286 complement(1588723..1589337) 1 NC_014215.1 hypothetical protein 1589337 9284286 PFREUD_14430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688368.1 1588723 R 754252 CDS YP_003688369.1 297626606 9282736 complement(1589349..1590254) 1 NC_014215.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Hydrolysis of DNA containing ring-opened 7-methylguanine residues; formamidopyrimidine-DNA glycosylase 1590254 mutM3 9282736 mutM3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 formamidopyrimidine-DNA glycosylase YP_003688369.1 1589349 R 754252 CDS YP_003688371.1 297626608 9282737 complement(1590254..1590976) 1 NC_014215.1 This is an endoribonuclease that cleaves double-stranded RNA molecules. The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site; ribonuclease III 1590976 rnc 9282737 rnc Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease III YP_003688371.1 1590254 R 754252 CDS YP_003688372.1 297626609 9284189 complement(1591326..1591886) 1 NC_014215.1 hypothetical protein 1591886 9284189 PFREUD_14470 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688372.1 1591326 R 754252 CDS YP_003688373.1 297626610 9282738 complement(1591974..1592459) 1 NC_014215.1 ATP + Pantetheine 4prime-phosphate <=> Pyrophosphate + Dephospho-CoA; phosphopantetheine adenylyltransferase 1592459 coaD 9282738 coaD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphopantetheine adenylyltransferase YP_003688373.1 1591974 R 754252 CDS YP_003688374.1 297626611 9283430 complement(1592452..1593051) 1 NC_014215.1 N6-adenine-specific methylase; methylase 1593051 9283430 PFREUD_14490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylase YP_003688374.1 1592452 R 754252 CDS YP_003688375.1 297626612 9282739 1593127..1593549 1 NC_014215.1 hypothetical protein 1593549 9282739 PFREUD_14500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688375.1 1593127 D 754252 CDS YP_003688376.1 297626613 9282740 complement(1593656..1595863) 1 NC_014215.1 Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3prime to 5prime polarity. RecG unwind branched duplex DNA (Y-DNA); ATP-dependent DNA helicase RecG 1595863 recG 9282740 recG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent DNA helicase RecG YP_003688376.1 1593656 R 754252 CDS YP_003688377.1 297626614 9284166 complement(1596065..1596250) 1 NC_014215.1 50S ribosomal protein L28 1596250 rpmB 9284166 rpmB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L28 YP_003688377.1 1596065 R 754252 CDS YP_003688378.1 297626615 9284223 complement(1596385..1598070) 1 NC_014215.1 beta-lactamase-like:RNA-metabolising metallo-beta-lactamase 1598070 9284223 PFREUD_14530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-lactamase-like:RNA-metabolising metallo-beta-lactamase YP_003688378.1 1596385 R 754252 CDS YP_003688379.1 297626616 9282741 1598182..1598712 1 NC_014215.1 acetyltransferase 1598712 9282741 PFREUD_14540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688379.1 1598182 D 754252 CDS YP_003688380.1 297626617 9282742 complement(1598725..1599420) 1 NC_014215.1 hypothetical protein 1599420 9282742 PFREUD_14550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688380.1 1598725 R 754252 CDS YP_003688381.1 297626618 9282743 complement(1599456..1600196) 1 NC_014215.1 2,3,4,5-Tetrahydrodipicolinate + NAD+ <=> L-2,3-dihydrodipicolinate + NADH + H+; dihydrodipicolinate reductase 1600196 dapB 9282743 dapB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrodipicolinate reductase YP_003688381.1 1599456 R 754252 CDS YP_003688382.1 297626619 9283476 complement(1600401..1602611) 1 NC_014215.1 Induced by several stresses and by starvation.; polyribonucleotide nucleotidyltransferase 1602611 pnpA 9283476 pnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polyribonucleotide nucleotidyltransferase YP_003688382.1 1600401 R 754252 CDS YP_003688383.1 297626620 9284087 complement(1602936..1603199) 1 NC_014215.1 30S ribosomal protein S15 1603199 rpsO 9284087 rpsO Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S15 YP_003688383.1 1602936 R 754252 CDS YP_003688384.1 297626621 9284248 complement(1603303..1604280) 1 NC_014215.1 ATP + FMN <=> Pyrophosphate + FAD / ATP + riboflavin <=> ADP + FMN; riboflavin biosynthesis protein 1604280 ribF 9284248 ribF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 riboflavin biosynthesis protein YP_003688384.1 1603303 R 754252 CDS YP_003688385.1 297626622 9284177 complement(1604606..1606132) 1 NC_014215.1 Key enzyme in the regulation of glycerol uptake and metabolism, glycerol utilization; first (rate-limiting) step, ATP + glycerol = ADP + sn-glycerol 3-phosphate; glycerol kinase 1606132 glpK 9284177 glpK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerol kinase YP_003688385.1 1604606 R 754252 CDS YP_003688386.1 297626623 9283632 complement(1606190..1606981) 1 NC_014215.1 FUNCTION: glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). # DOMAIN: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).; glycerol uptake facilitator protein 1606981 glpF 9283632 glpF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerol uptake facilitator protein YP_003688386.1 1606190 R 754252 CDS YP_003688387.1 297626624 9283631 complement(1607226..1608122) 1 NC_014215.1 Uracil + D-ribose 5-phosphate <=> pseudouridine 5prime-phosphate + H2O; tRNA pseudouridine synthase B 1608122 truB 9283631 truB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA pseudouridine synthase B YP_003688387.1 1607226 R 754252 CDS YP_003688388.1 297626625 9284434 complement(1608119..1608559) 1 NC_014215.1 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5 prime-terminal helix region of 16S rRNA; ribosome-binding factor A 1608559 rbfA 9284434 rbfA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribosome-binding factor A YP_003688388.1 1608119 R 754252 CDS YP_003688389.1 297626626 9284159 complement(1608559..1611480) 1 NC_014215.1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1611480 infB 9284159 infB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 translation initiation factor IF-2 YP_003688389.1 1608559 R 754252 CDS YP_003688390.1 297626627 9283745 complement(1611676..1611873) 1 NC_014215.1 hypothetical protein 1611873 9283745 PFREUD_14650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688390.1 1611676 R 754252 CDS YP_003688391.1 297626628 9282744 complement(1612020..1613078) 1 NC_014215.1 transcription termination/ antitermination factor NusA 1613078 nusA 9282744 nusA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription termination/ antitermination factor NusA YP_003688391.1 1612020 R 754252 CDS YP_003688392.1 297626629 9283977 complement(1613080..1613553) 1 NC_014215.1 hypothetical protein 1613553 9283977 PFREUD_14670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688392.1 1613080 R 754252 CDS YP_003688393.1 297626630 9282745 1613823..1614809 1 NC_014215.1 hypothetical protein 1614809 9282745 PFREUD_14680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688393.1 1613823 D 754252 CDS YP_003688394.1 297626631 9282746 complement(1614868..1616634) 1 NC_014215.1 prolyl-tRNA synthetase 1616634 proS 9282746 proS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 prolyl-tRNA synthetase YP_003688394.1 1614868 R 754252 CDS YP_003688395.1 297626632 9284121 complement(1616773..1617603) 1 NC_014215.1 acetyltransferase 1617603 9284121 PFREUD_14700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688395.1 1616773 R 754252 CDS YP_003688396.1 297626633 9282747 complement(1617755..1618921) 1 NC_014215.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein dithiol <=> 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + H2O + protein disulfide; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1618921 ispG 9282747 ispG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_003688396.1 1617755 R 754252 CDS YP_003688397.1 297626634 9283796 complement(1618994..1620169) 1 NC_014215.1 2-C-methyl-D-erythritol 4-phosphate + NADP+ <=> 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1620169 dxr 9283796 dxr Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_003688397.1 1618994 R 754252 CDS YP_003688398.1 297626635 9283529 complement(1620258..1621385) 1 NC_014215.1 hypothetical protein 1621385 9283529 PFREUD_14730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688398.1 1620258 R 754252 CDS YP_003688399.1 297626636 9282748 complement(1621391..1622236) 1 NC_014215.1 CTP + phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; phosphatidate cytidylyltransferase 1622236 cdsA 9282748 cdsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphatidate cytidylyltransferase YP_003688399.1 1621391 R 754252 CDS YP_003688400.1 297626637 9283412 complement(1622245..1622802) 1 NC_014215.1 ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.; ribosome recycling factor 1622802 frr 9283412 frr Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribosome recycling factor YP_003688400.1 1622245 R 754252 CDS YP_003688401.1 297626638 9283576 complement(1622875..1623624) 1 NC_014215.1 uridylate kinase 1623624 pyrH 9283576 pyrH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 uridylate kinase YP_003688401.1 1622875 R 754252 CDS YP_003688402.1 297626639 9284158 complement(1623761..1624573) 1 NC_014215.1 elongation factor Ts 1624573 tsf 9284158 tsf Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 elongation factor Ts YP_003688402.1 1623761 R 754252 CDS YP_003688403.1 297626640 9284442 complement(1624612..1625589) 1 NC_014215.1 30S ribosomal protein S2 1625589 rpsB 9284442 rpsB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S2 YP_003688403.1 1624612 R 754252 CDS YP_003688404.1 297626641 9284236 1625883..1627067 1 NC_014215.1 hypothetical protein 1627067 9284236 PFREUD_14790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688404.1 1625883 D 754252 CDS YP_003688405.1 297626642 9282749 complement(1627111..1628037) 1 NC_014215.1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids; integrase/recombinase 1628037 xerC 9282749 xerC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase/recombinase YP_003688405.1 1627111 R 754252 CDS YP_003688406.1 297626643 9284477 1628186..1628806 1 NC_014215.1 formyl-L-methionyl peptide + H2O <=> methionyl peptide + formate; polypeptide deformylase 1628806 def 9284477 def Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polypeptide deformylase YP_003688406.1 1628186 D 754252 CDS YP_003688407.1 297626644 9283486 complement(1628840..1629649) 1 NC_014215.1 Belongs to the RNA methyltransferase trmH family. RNA processing; tRNA/rRNA methyltransferase 1629649 spoU2 9283486 spoU2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA/rRNA methyltransferase YP_003688407.1 1628840 R 754252 CDS YP_003688408.1 297626645 9284293 1629790..1630833 1 NC_014215.1 transporter, sodium/bile acid symporter family 1630833 9284293 PFREUD_14830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transporter, sodium/bile acid symporter family YP_003688408.1 1629790 D 754252 CDS YP_003688409.1 297626646 9282750 complement(1630915..1631709) 1 NC_014215.1 ABC transporter ATP-binding protein 1631709 PPA1530 9282750 PPA1530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688409.1 1630915 R 754252 CDS YP_003688410.1 297626647 9284101 1631862..1632611 1 NC_014215.1 hypothetical protein 1632611 9284101 PFREUD_14850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688410.1 1631862 D 754252 CDS YP_003688411.1 297626648 9282751 complement(1632686..1633459) 1 NC_014215.1 enoyl-ACP reductase (NADH) 1633459 inhA 9282751 inhA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 enoyl-ACP reductase (NADH) YP_003688411.1 1632686 R 754252 CDS YP_003688412.1 297626649 9283747 complement(1633549..1634283) 1 NC_014215.1 (3R)-3-Hydroxyacyl-ACP + NADP+ <=> 3-Oxoacyl-ACP + NADPH + H+; 3-oxoacyl-ACP reductase 1634283 fabG 9283747 fabG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-oxoacyl-ACP reductase YP_003688412.1 1633549 R 754252 CDS YP_003688413.1 297626650 9283540 1634353..1635099 1 NC_014215.1 dehydrogenase 1635099 9283540 PFREUD_14880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dehydrogenase YP_003688413.1 1634353 D 754252 CDS YP_003688414.1 297626651 9282752 1635107..1635940 1 NC_014215.1 Confers strong resistance to mycinamicin (MM) and tylosin (TY).; resistance protein 1635940 myrA 9282752 myrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 resistance protein YP_003688414.1 1635107 D 754252 CDS YP_003688416.1 297626653 9282753 complement(1636091..1637689) 1 NC_014215.1 ABC transporter ATP-binding protein 1637689 9282753 PFREUD_14910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688416.1 1636091 R 754252 CDS YP_003688417.1 297626654 9282754 complement(1637963..1638412) 1 NC_014215.1 hypothetical protein 1638412 9282754 PFREUD_14920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688417.1 1637963 R 754252 CDS YP_003688418.1 297626655 9282755 complement(1638409..1638861) 1 NC_014215.1 The nif genes are responsible for nitrogen fixation. However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation.; Nitrogen-fixing NifU-like 1638861 nifU1 9282755 nifU1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Nitrogen-fixing NifU-like YP_003688418.1 1638409 R 754252 CDS YP_003688419.1 297626656 9283951 complement(1638858..1640114) 1 NC_014215.1 cysteine desulfurase 1640114 sufS 9283951 sufS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cysteine desulfurase YP_003688419.1 1638858 R 754252 CDS YP_003688420.1 297626657 9284307 complement(1640104..1640853) 1 NC_014215.1 The SUF system of Escherichia coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; ABC transporter ATPase 1640853 sufC 9284307 sufC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATPase YP_003688420.1 1640104 R 754252 CDS YP_003688421.1 297626658 9284305 complement(1640858..1641205) 1 NC_014215.1 dioxygenase 1641205 9284305 PFREUD_14960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dioxygenase YP_003688421.1 1640858 R 754252 CDS YP_003688422.1 297626659 9282756 complement(1641202..1642419) 1 NC_014215.1 FeS assembly protein SufD 1642419 sufD 9282756 sufD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FeS assembly protein SufD YP_003688422.1 1641202 R 754252 CDS YP_003688423.1 297626660 9284306 complement(1642419..1643876) 1 NC_014215.1 FeS assembly protein SufB 1643876 sufB 9284306 sufB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 FeS assembly protein SufB YP_003688423.1 1642419 R 754252 CDS YP_003688424.1 297626661 9284304 complement(1643873..1644637) 1 NC_014215.1 ArsR family transcriptional regulator 1644637 arsR4 9284304 arsR4 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003688424.1 1643873 R 754252 CDS YP_003688425.1 297626662 9283351 1644906..1645280 1 NC_014215.1 transcriptional regulator 1645280 9283351 PFREUD_15000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688425.1 1644906 D 754252 CDS YP_003688426.1 297626663 9282757 1645277..1645975 1 NC_014215.1 ABC transporter ATP-binding protein 1645975 9282757 PFREUD_15010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688426.1 1645277 D 754252 CDS YP_003688427.1 297626664 9282758 1645972..1646787 1 NC_014215.1 hypothetical protein 1646787 9282758 PFREUD_15020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688427.1 1645972 D 754252 CDS YP_003688428.1 297626665 9282759 complement(1646939..1647559) 1 NC_014215.1 Molecular function: transferase activity, Biological process: glutamine catabolic process and pyridoxal phosphate biosynthetic process; glutamine amidotransferase subunit PdxT 1647559 pdxT 9282759 pdxT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine amidotransferase subunit PdxT YP_003688428.1 1646939 R 754252 CDS YP_003688429.1 297626666 9284023 complement(1647564..1648454) 1 NC_014215.1 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring. Cofactor biosynthesis, pyridoxal 5_phosphate biosynthesis-forms a complex with pdxT, induction by indole. Belongs to the pdxS/SNZ family; pyridoxal biosynthesis lyase PdxS 1648454 pdxS 9284023 pdxS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyridoxal biosynthesis lyase PdxS YP_003688429.1 1647564 R 754252 CDS YP_003688430.1 297626667 9284022 1648550..1649980 1 NC_014215.1 transcriptional regulator 1649980 9284022 PFREUD_15050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688430.1 1648550 D 754252 CDS YP_003688431.1 297626668 9282760 1650133..1651752 1 NC_014215.1 D-glucose 6-phosphate + NADP+ <=> D-glucono-1,5-lactone 6-phosphate + NADPH + H+; glucose-6-phosphate 1-dehydrogenase 1651752 zwf 9282760 zwf Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glucose-6-phosphate 1-dehydrogenase YP_003688431.1 1650133 D 754252 CDS YP_003688432.1 297626669 9284494 1651763..1652665 1 NC_014215.1 allosteric effector of glucose-6-phosphate dehydrogenase; glucose 6-phosphate dehydrogenase effector OpcA 1652665 opcA 9284494 opcA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glucose 6-phosphate dehydrogenase effector OpcA YP_003688432.1 1651763 D 754252 CDS YP_003688433.1 297626670 9283982 1652677..1653420 1 NC_014215.1 D-glucono-1,5-lactone 6-phosphate + H2O <=> 6-phospho-D-gluconate; 6-phosphogluconolactonase 1653420 devB 9283982 devB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 6-phosphogluconolactonase YP_003688433.1 1652677 D 754252 CDS YP_003688434.1 297626671 9283490 complement(1653737..1654093) 1 NC_014215.1 electron transport protein 1654093 9283490 PFREUD_15090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 electron transport protein YP_003688434.1 1653737 R 754252 CDS YP_003688435.1 297626672 9282761 complement(1654166..1654411) 1 NC_014215.1 hypothetical protein 1654411 9282761 PFREUD_15100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688435.1 1654166 R 754252 CDS YP_003688436.1 297626673 9282762 complement(1654549..1655337) 1 NC_014215.1 D-glyceraldehyde 3-phosphate = glycerone phosphate, homodimer; triosephosphate isomerase 1 1655337 tpi1 9282762 tpi1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 triosephosphate isomerase 1 YP_003688436.1 1654549 R 754252 CDS YP_003688437.1 297626674 9284415 complement(1655340..1656551) 1 NC_014215.1 phosphoglycerate kinase 1656551 pgk 9284415 pgk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate kinase YP_003688437.1 1655340 R 754252 CDS YP_003688438.1 297626675 9284059 complement(1656715..1657719) 1 NC_014215.1 D-glyceraldehyde-3-phosphate + phosphate + NAD+ = 1,3-diphosphateglycerate + NADH // D-Erythrose 4-phosphate + NAD+ + H2O <=> 4-phospho-D-erythronate + NADH + H+ et; glyceraldehyde-3-phosphate dehydrogenase 1657719 gap 9284059 gap Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glyceraldehyde-3-phosphate dehydrogenase YP_003688438.1 1656715 R 754252 CDS YP_003688439.1 297626676 9283599 complement(1657833..1658405) 1 NC_014215.1 hypothetical protein 1658405 9283599 PFREUD_15140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688439.1 1657833 R 754252 CDS YP_003688440.1 297626677 9282763 complement(1658372..1659211) 1 NC_014215.1 hypothetical protein 1659211 9282763 PFREUD_15150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688440.1 1658372 R 754252 CDS YP_003688441.1 297626678 9282765 complement(1659997..1661034) 1 NC_014215.1 hypothetical protein 1661034 9282765 PFREUD_15170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688441.1 1659997 R 754252 CDS YP_003688442.1 297626679 9282766 complement(1661024..1661992) 1 NC_014215.1 hypothetical protein 1661992 9282766 PFREUD_15180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688442.1 1661024 R 754252 CDS YP_003688443.1 297626680 9282767 complement(1661989..1662873) 1 NC_014215.1 This family contains an ATP-binding site and could be an ATPase; ATPase 1662873 9282767 PFREUD_15190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase YP_003688443.1 1661989 R 754252 CDS YP_003688444.1 297626681 9282768 complement(1663042..1665036) 1 NC_014215.1 excinuclease ABC subunit C 1665036 uvrC 9282768 uvrC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 excinuclease ABC subunit C YP_003688444.1 1663042 R 754252 CDS YP_003688445.1 297626682 9284468 1665156..1666523 1 NC_014215.1 signal transduction histidine kinase 1666523 9284468 PFREUD_15210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 signal transduction histidine kinase YP_003688445.1 1665156 D 754252 CDS YP_003688446.1 297626683 9282769 1666498..1667151 1 NC_014215.1 two-component response regulator 1667151 9282769 PFREUD_15220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component response regulator YP_003688446.1 1666498 D 754252 CDS YP_003688447.1 297626684 9282770 1667254..1668135 1 NC_014215.1 ABC transporter ATP-binding protein 1668135 9282770 PFREUD_15230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688447.1 1667254 D 754252 CDS YP_003688448.1 297626685 9282771 1668132..1669298 1 NC_014215.1 sodium ABC transporter permease 1669298 9282771 PFREUD_15240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sodium ABC transporter permease YP_003688448.1 1668132 D 754252 CDS YP_003688449.1 297626686 9282772 1669440..1669976 1 NC_014215.1 acetyltransferase 1669976 9282772 PFREUD_15250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688449.1 1669440 D 754252 CDS YP_003688450.1 297626687 9282773 complement(1669991..1673047) 1 NC_014215.1 excinuclease ABC subunit A 1673047 uvrA3 9282773 uvrA3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 excinuclease ABC subunit A YP_003688450.1 1669991 R 754252 CDS YP_003688451.1 297626688 9284465 1673268..1674014 1 NC_014215.1 hypothetical protein 1674014 9284465 PFREUD_15270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688451.1 1673268 D 754252 CDS YP_003688452.1 297626689 9282774 1674016..1674609 1 NC_014215.1 beta-lactamase-like protein 1674609 9282774 PFREUD_15280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-lactamase-like protein YP_003688452.1 1674016 D 754252 CDS YP_003688453.1 297626690 9282775 complement(1674644..1675678) 1 NC_014215.1 TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions.s; membrane protein TerC 1675678 terC 9282775 terC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 membrane protein TerC YP_003688453.1 1674644 R 754252 CDS YP_003688454.1 297626691 9284319 complement(1675869..1677953) 1 NC_014215.1 excinuclease ABC subunit B 1677953 uvrB 9284319 uvrB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 excinuclease ABC subunit B YP_003688454.1 1675869 R 754252 CDS YP_003688455.1 297626692 9284467 complement(1678028..1678696) 1 NC_014215.1 ATP + Dephospho-CoA <=> ADP + CoA; dephospho-CoA kinase 1678696 coaE 9284467 coaE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dephospho-CoA kinase YP_003688455.1 1678028 R 754252 CDS YP_003688456.1 297626693 9283431 complement(1678700..1679476) 1 NC_014215.1 uridine phosphorylase 1679476 9283431 PFREUD_15320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 uridine phosphorylase YP_003688456.1 1678700 R 754252 CDS YP_003688457.1 297626694 9282776 complement(1679593..1681047) 1 NC_014215.1 30S ribosomal protein S1 1681047 rpsA 9282776 rpsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S1 YP_003688457.1 1679593 R 754252 CDS YP_003688458.1 297626695 9284235 complement(1681410..1682876) 1 NC_014215.1 aldehyde dehydrogenase 1682876 gab 9284235 gab Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aldehyde dehydrogenase YP_003688458.1 1681410 R 754252 CDS YP_003688459.1 297626696 9283589 1683096..1683809 1 NC_014215.1 hypothetical protein 1683809 9283589 PFREUD_15350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688459.1 1683096 D 754252 CDS YP_003688460.1 297626697 9282777 complement(1683829..1686507) 1 NC_014215.1 deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).; DNA polymerase I 1686507 polA 9282777 polA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase I YP_003688460.1 1683829 R 754252 CDS YP_003688461.1 297626698 9284091 complement(1686614..1687237) 1 NC_014215.1 two-component system response regulator 1687237 9284091 PFREUD_15370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system response regulator YP_003688461.1 1686614 R 754252 CDS YP_003688462.1 297626699 9282779 complement(1687773..1689272) 1 NC_014215.1 ATP + pyruvate <=> ADP + phosphoenolpyruvate; pyruvate kinase 1 1689272 pyk1 9282779 pyk1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyruvate kinase 1 YP_003688462.1 1687773 R 754252 CDS YP_003688463.1 297626700 9284151 complement(1689522..1690442) 1 NC_014215.1 RNA uridine = RNA pseudouridine.; pseudouridylate synthase 1690442 rluA 9284151 rluA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pseudouridylate synthase YP_003688463.1 1689522 R 754252 CDS YP_003688464.1 297626701 9284183 complement(1690439..1690984) 1 NC_014215.1 This protein specifically catalyzes the removal of signal peptides from prolipoproteins. Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side subunits.; lipoprotein signal peptidase 1690984 LspA 9284183 LspA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lipoprotein signal peptidase YP_003688464.1 1690439 R 754252 CDS YP_003688465.1 297626702 9283837 complement(1691041..1691469) 1 NC_014215.1 TraR/DksA family transcriptional regulator 1691469 dskA 9283837 dskA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TraR/DksA family transcriptional regulator YP_003688465.1 1691041 R 754252 CDS YP_003688466.1 297626703 9283525 complement(1691544..1692542) 1 NC_014215.1 hypothetical protein 1692542 9283525 PFREUD_15430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688466.1 1691544 R 754252 CDS YP_003688467.1 297626704 9282780 complement(1692679..1692972) 1 NC_014215.1 hypothetical protein 1692972 9282780 PFREUD_15440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688467.1 1692679 R 754252 CDS YP_003688468.1 297626705 9282781 complement(1692976..1693497) 1 NC_014215.1 hypothetical protein 1693497 9282781 PFREUD_15450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688468.1 1692976 R 754252 CDS YP_003688469.1 297626706 9282782 complement(1693649..1694437) 1 NC_014215.1 hypothetical protein 1694437 9282782 PFREUD_15460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688469.1 1693649 R 754252 CDS YP_003688470.1 297626707 9282783 complement(1694447..1695688) 1 NC_014215.1 The protein forms a ring at the leading edge of the cell division site; cell division protein FtsZ 1695688 ftsZ 9282783 ftsZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell division protein FtsZ YP_003688470.1 1694447 R 754252 CDS YP_003688471.1 297626708 9283585 complement(1695906..1696637) 1 NC_014215.1 FtsQ is one of several cell division proteins. FtsQ interacts with other Fts proteins. The precise function of FtsQ is unknown.; cell division protein FtsQ 1696637 ftsQ 9283585 ftsQ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell division protein FtsQ YP_003688471.1 1695906 R 754252 CDS YP_003688472.1 297626709 9283580 complement(1696634..1698076) 1 NC_014215.1 cell wall formation- ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.; UDP-N-acetylmuramate--L-alanine ligase 1698076 murC 9283580 murC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylmuramate--L-alanine ligase YP_003688472.1 1696634 R 754252 CDS YP_003688473.1 297626710 9283918 complement(1698073..1699173) 1 NC_014215.1 UDP-N-acetylglucosamine +Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol = UDP +GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)-diphosphoundecaprenol; UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-UDP N-acetylglucosamine transferase 1699173 murG 9283918 murG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-UDP N-acetylglucosamine transferase YP_003688473.1 1698073 R 754252 CDS YP_003688474.1 297626711 9283922 complement(1699173..1700438) 1 NC_014215.1 cell division protein FtsW 1700438 ftsW1 9283922 ftsW1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell division protein FtsW YP_003688474.1 1699173 R 754252 CDS YP_003688475.1 297626712 9283581 complement(1700631..1702115) 1 NC_014215.1 ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate; UDP-N-acetylmuramoylalanine--D-glutamate ligase 1702115 murD 9283581 murD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_003688475.1 1700631 R 754252 CDS YP_003688476.1 297626713 9283919 complement(1702112..1703188) 1 NC_014215.1 phospho-N-acetylmuramoyl-pentapeptide- transferase 1703188 mraY 9283919 mraY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_003688476.1 1702112 R 754252 CDS YP_003688477.1 297626714 9283907 complement(1703185..1704717) 1 NC_014215.1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D- alanyl-D-alanine. Belongs to the murCDEF family.; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 1704717 murF 9283907 murF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_003688477.1 1703185 R 754252 CDS YP_003688478.1 297626715 9283921 complement(1704671..1706260) 1 NC_014215.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1706260 murE 9283921 murE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_003688478.1 1704671 R 754252 CDS YP_003688479.1 297626716 9283920 complement(1706260..1708134) 1 NC_014215.1 transpeptidase activity involved in the biosynthesis of septal peptidoglycan; cell division protein FtsI 1708134 ftsI 9283920 ftsI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell division protein FtsI YP_003688479.1 1706260 R 754252 CDS YP_003688480.1 297626717 9283578 complement(1708320..1708838) 1 NC_014215.1 hypothetical protein 1708838 9283578 PFREUD_15570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688480.1 1708320 R 754252 CDS YP_003688481.1 297626718 9282784 complement(1708835..1709863) 1 NC_014215.1 S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; S-adenosyl-L-methionine-dependent methyltransferase mraW 1709863 mraW 9282784 mraW Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S-adenosyl-L-methionine-dependent methyltransferase mraW YP_003688481.1 1708835 R 754252 CDS YP_003688482.1 297626719 9283906 complement(1710042..1710479) 1 NC_014215.1 belongs to the mra (murein region A) gene cluster, involved in cell wall biosynthesis and cell division; protein mraZ 1710479 mraZ 9283906 mraZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein mraZ YP_003688482.1 1710042 R 754252 CDS YP_003688484.1 297626721 9282785 complement(1710702..1711085) 1 NC_014215.1 hypothetical protein 1711085 9282785 PFREUD_15610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688484.1 1710702 R 754252 CDS YP_003688485.1 297626722 9282786 complement(1711125..1712357) 1 NC_014215.1 Catalyses DNA-template-directed extension of the 3prime- end of a DNA strand by one nucleotide at a time. Cannot initiate a subunit de novo. Requires a primer, which may be DNA or RNA.; DNA-directed DNA polymerase 1712357 dinP 9282786 dinP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA-directed DNA polymerase YP_003688485.1 1711125 R 754252 CDS YP_003688487.1 297626724 9282787 complement(1712393..1715938) 1 NC_014215.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).; DNA polymerase III subunit alpha 1715938 dnaE2 9282787 dnaE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase III subunit alpha YP_003688487.1 1712393 R 754252 CDS YP_003688488.1 297626725 9283510 complement(1716025..1716426) 1 NC_014215.1 hypothetical protein 1716426 9283510 PFREUD_15650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688488.1 1716025 R 754252 CDS YP_003688489.1 297626726 9282788 1716640..1718850 1 NC_014215.1 ATP-dependent DNA helicase activity; Helicase protein 1718850 9282788 PFREUD_15660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Helicase protein YP_003688489.1 1716640 D 754252 CDS YP_003688490.1 297626727 9282789 complement(1718804..1719745) 1 NC_014215.1 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.; 5,10-methylenetetrahydrofolate reductase 1719745 metF 9282789 metF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 5,10-methylenetetrahydrofolate reductase YP_003688490.1 1718804 R 754252 CDS YP_003688491.1 297626728 9283878 1719785..1720861 1 NC_014215.1 trans,trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; farnesyltranstransferase/geranylgeranyl pyrophosphate synthase 1720861 9283878 PFREUD_15680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 farnesyltranstransferase/geranylgeranyl pyrophosphate synthase YP_003688491.1 1719785 D 754252 CDS YP_003688492.1 297626729 9282790 1721012..1723255 1 NC_014215.1 hypothetical protein 1723255 9282790 PFREUD_15690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688492.1 1721012 D 754252 CDS YP_003688493.1 297626730 9282791 1723298..1724221 1 NC_014215.1 hypothetical protein 1724221 9282791 PFREUD_15700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688493.1 1723298 D 754252 CDS YP_003688494.1 297626731 9282792 complement(1724234..1724890) 1 NC_014215.1 Zn-dependent hydrolase, beta-lactamase fold 1724890 9282792 PFREUD_15710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Zn-dependent hydrolase, beta-lactamase fold YP_003688494.1 1724234 R 754252 CDS YP_003688495.1 297626732 9282793 complement(1725008..1726393) 1 NC_014215.1 phosphoenolpyruvate + D-Erythrose 4-phosphate + H2O <=> 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Orthophosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1726393 aroH 9282793 aroH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phospho-2-dehydro-3-deoxyheptonate aldolase YP_003688495.1 1725008 R 754252 CDS YP_003688496.1 297626733 9283343 complement(1726505..1727455) 1 NC_014215.1 phosphatidate + CoA <=> 1-acyl-sn-glycerol 3-phosphate + acyl-CoA and 2,3-Dehydroacyl-CoA + 1-acyl-sn-glycerol 3-phosphate <=> CoA + phosphatidate and acyl-CoA + 1-Alkyl-sn-glycero-3-phosphate <=> CoA + 2-acyl-1-alkyl-sn-glycero-3-phosphate; 1-acylglycerol-3-phosphate O-acyltransferase 1727455 pls 9283343 pls Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 1-acylglycerol-3-phosphate O-acyltransferase YP_003688496.1 1726505 R 754252 CDS YP_003688497.1 297626734 9284080 complement(1727439..1728284) 1 NC_014215.1 smart00563, phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities.; acyltransferase 1728284 plsC3 9284080 plsC3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acyltransferase YP_003688497.1 1727439 R 754252 CDS YP_003688498.1 297626735 9284083 complement(1728401..1729522) 1 NC_014215.1 membrane proteins related to metalloendopeptidases; peptidase M23B 1729522 9284083 PFREUD_15750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase M23B YP_003688498.1 1728401 R 754252 CDS YP_003688499.1 297626736 9282794 1729782..1730051 1 NC_014215.1 AsnC family transcriptional regulator 1730051 9282794 PFREUD_15760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 AsnC family transcriptional regulator YP_003688499.1 1729782 D 754252 CDS YP_003688500.1 297626737 9282795 complement(1730182..1730694) 1 NC_014215.1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Belongs to the cyclophilin-type PPIase family.; peptidyl-prolyl cis-trans isomerase A 1730694 ppiA 9282795 ppiA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidyl-prolyl cis-trans isomerase A YP_003688500.1 1730182 R 754252 CDS YP_003688501.1 297626738 9284109 1731021..1732037 1 NC_014215.1 hypothetical protein 1732037 9284109 PFREUD_15780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688501.1 1731021 D 754252 CDS YP_003688502.1 297626739 9282796 1732226..1733323 1 NC_014215.1 acetyltransferases, including N-acetylases of ribosomal proteins; acetyltransferase 1733323 rimL 9282796 rimL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688502.1 1732226 D 754252 CDS YP_003688503.1 297626740 9284181 1733415..1734083 1 NC_014215.1 hypothetical protein 1734083 9284181 PFREUD_15800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688503.1 1733415 D 754252 CDS YP_003688504.1 297626741 9282797 1734109..1734792 1 NC_014215.1 hypothetical protein 1734792 9282797 PFREUD_15810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688504.1 1734109 D 754252 CDS YP_003688505.1 297626742 9282798 1734932..1735357 1 NC_014215.1 hypothetical protein 1735357 9282798 PFREUD_15820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688505.1 1734932 D 754252 CDS YP_003688506.1 297626743 9282799 complement(1735398..1736447) 1 NC_014215.1 N-(5-phospho-D-ribosyl)anthranilate + Pyrophosphate <=> Anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1736447 trpD 9282799 trpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anthranilate phosphoribosyltransferase YP_003688506.1 1735398 R 754252 CDS YP_003688507.1 297626744 9284430 complement(1736447..1736971) 1 NC_014215.1 Response regulator receiver protein 1736971 9284430 PFREUD_15840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Response regulator receiver protein YP_003688507.1 1736447 R 754252 CDS YP_003688508.1 297626745 9282800 1737184..1738647 1 NC_014215.1 IMP + NAD+ + H2O <=> Xanthosine 5prime-phosphate + NADH + H+; inosine-5'-monophosphate dehydrogenase 1738647 guaB3 9282800 guaB3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inosine-5'-monophosphate dehydrogenase YP_003688508.1 1737184 D 754252 CDS YP_003688509.1 297626746 9283677 complement(1738786..1739136) 1 NC_014215.1 HesB. may be involved in nitrogen fixation; the hesB gene is expressed only under nitrogen fixation conditions. Other members of this family include various hypothetical proteins of which some also contain NifU-like domains pfam01106 which is also involved in nitrogen fixation. In the gram-negative soil bacterium Rhizobium etli, the hesB-like gene iscN is required for nitrogen fixation.; HesB protein 1739136 9283677 PFREUD_15860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 HesB protein YP_003688509.1 1738786 R 754252 CDS YP_003688510.1 297626747 9282801 complement(1739294..1740226) 1 NC_014215.1 hypothetical protein 1740226 9282801 PFREUD_15870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688510.1 1739294 R 754252 CDS YP_003688511.1 297626748 9282802 complement(1740230..1740520) 1 NC_014215.1 hypothetical protein 1740520 9282802 PFREUD_15880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688511.1 1740230 R 754252 CDS YP_003688512.1 297626749 9282803 complement(1740517..1741311) 1 NC_014215.1 Repressor of p54 sigma factor. t has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.; phage shock protein A 1741311 pspA 9282803 pspA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage shock protein A YP_003688512.1 1740517 R 754252 CDS YP_003688514.1 297626751 9282804 1741611..1742165 1 NC_014215.1 hypothetical protein 1742165 9282804 PFREUD_15910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688514.1 1741611 D 754252 CDS YP_003688515.1 297626752 9282805 1742165..1742380 1 NC_014215.1 hypothetical protein 1742380 9282805 PFREUD_15920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688515.1 1742165 D 754252 CDS YP_003688516.1 297626753 9282806 complement(1742535..1743692) 1 NC_014215.1 S-aminomethyldihydrolipoylprotein + Tetrahydrofolate <=> dihydrolipoylprotein + 5,10-methylenetetrahydrofolate + NH3; glycine cleavage system protein T 1743692 gcvT1 9282806 gcvT1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine cleavage system protein T YP_003688516.1 1742535 R 754252 CDS YP_003688517.1 297626754 9283606 1743957..1745726 1 NC_014215.1 Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine , glutaryl-CoA + dihydrolipoamide <=> CoA + S-glutaryldihydrolipoamide; dihydrolipoamide acyltransferase 1745726 pdhB 9283606 pdhB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrolipoamide acyltransferase YP_003688517.1 1743957 D 754252 CDS YP_003688518.1 297626755 9284006 1746010..1746780 1 NC_014215.1 hypothetical protein 1746780 9284006 PFREUD_15950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688518.1 1746010 D 754252 CDS YP_003688519.1 297626756 9282807 1746813..1748624 1 NC_014215.1 ABC transporter 1748624 9282807 PFREUD_15960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003688519.1 1746813 D 754252 CDS YP_003688520.1 297626757 9282808 1748800..1750239 1 NC_014215.1 glutamate metabolism : ATP + L-glutamate + NH3 <=> ADP + Orthophosphate + L-glutamine , peptidoglycan biosynthesis; glutamine synthetase 1750239 9282808 PFREUD_15970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine synthetase YP_003688520.1 1748800 D 754252 CDS YP_003688521.1 297626758 9282809 1750532..1751074 1 NC_014215.1 hypothetical protein 1751074 9282809 PFREUD_15980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688521.1 1750532 D 754252 CDS YP_003688522.1 297626759 9282810 1751165..1751749 1 NC_014215.1 Biological process: regulation of transcription, DNA-dependent , response to antibiotic; TetR family transcriptional regulator 1751749 9282810 PFREUD_15990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003688522.1 1751165 D 754252 CDS YP_003688523.1 297626760 9282811 complement(1751769..1752584) 1 NC_014215.1 Short-subunit dehydrogenases of various substrate specificities; dehydrogenase 1752584 9282811 PFREUD_16000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dehydrogenase YP_003688523.1 1751769 R 754252 CDS YP_003688524.1 297626761 9282812 complement(1752581..1755547) 1 NC_014215.1 ATP + [L-glutamate:ammonia ligase (ADP-forming)] <=> Pyrophosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]; glutamate-ammonia-ligase adenylyltransferase 1755547 glnE 9282812 glnE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate-ammonia-ligase adenylyltransferase YP_003688524.1 1752581 R 754252 CDS YP_003688525.1 297626762 9283624 1755789..1756526 1 NC_014215.1 hypothetical protein 1756526 9283624 PFREUD_16020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688525.1 1755789 D 754252 CDS YP_003688526.1 297626763 9282813 complement(1756582..1757916) 1 NC_014215.1 # ATP + L-glutamate + NH3 <=> ADP + Orthophosphate + L-glutamine; glutamine synthetase 1757916 glnA 9282813 glnA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine synthetase YP_003688526.1 1756582 R 754252 CDS YP_003688527.1 297626764 9283622 1758123..1759004 1 NC_014215.1 hypothetical protein 1759004 9283622 PFREUD_16040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688527.1 1758123 D 754252 CDS YP_003688528.1 297626765 9282814 1759089..1760036 1 NC_014215.1 hypothetical protein 1760036 9282814 PFREUD_16050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688528.1 1759089 D 754252 CDS YP_003688529.1 297626766 9282815 1760116..1761024 1 NC_014215.1 Removes the amino-terminal methionine from nascent proteins. Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. Binds 2 cobalt ions per subunit. Belongs to the peptidase M24A family; methionine aminopeptidase 1761024 map 9282815 map Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methionine aminopeptidase YP_003688529.1 1760116 D 754252 CDS YP_003688530.1 297626767 9283856 complement(1761163..1762008) 1 NC_014215.1 hypothetical protein 1762008 9283856 PFREUD_16070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688530.1 1761163 R 754252 CDS YP_003688531.1 297626768 9282816 complement(1762599..1763342) 1 NC_014215.1 hypothetical protein 1763342 9282816 PFREUD_16080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688531.1 1762599 R 754252 CDS YP_003688532.1 297626769 9282817 1763524..1764969 1 NC_014215.1 Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Binds 2 manganese ions per subunit.Belongs to the peptidase M24B family; Xaa-Pro aminopeptidase 1764969 pepP 9282817 pepP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Xaa-Pro aminopeptidase YP_003688532.1 1763524 D 754252 CDS YP_003688533.1 297626770 9284030 complement(1765096..1765962) 1 NC_014215.1 hypothetical protein 1765962 9284030 PFREUD_16100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688533.1 1765096 R 754252 CDS YP_003688534.1 297626771 9282818 complement(1766107..1766970) 1 NC_014215.1 Citrate <=> acetate + Oxaloacetate / (3S)-Citryl-CoA <=> acetyl-CoA + Oxaloacetate; citrate lyase subunit beta 1766970 citE 9282818 citE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 citrate lyase subunit beta YP_003688534.1 1766107 R 754252 CDS YP_003688535.1 297626772 9283418 1767139..1768428 1 NC_014215.1 magnesium (Mg2+) transporter 1768428 mgtE 9283418 mgtE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 magnesium (Mg2+) transporter YP_003688535.1 1767139 D 754252 CDS YP_003688536.1 297626773 9283884 1768425..1768988 1 NC_014215.1 hypothetical protein 1768988 9283884 PFREUD_16130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688536.1 1768425 D 754252 CDS YP_003688537.1 297626774 9282819 1769132..1770289 1 NC_014215.1 proteins of the Mrp family are involved in stress adaptation; protein mrp (ATP-binding protein) 1770289 PF47 9282819 PF47 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein mrp (ATP-binding protein) YP_003688537.1 1769132 D 754252 CDS YP_003688538.1 297626775 9284050 complement(1770456..1770905) 1 NC_014215.1 Sec-independent protein translocase protein TatB 1770905 tatB 9284050 tatB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sec-independent protein translocase protein TatB YP_003688538.1 1770456 R 754252 CDS YP_003688539.1 297626776 9284315 complement(1771000..1771845) 1 NC_014215.1 L-aspartate 4-semialdehyde + pyruvate <=> L-2,3-dihydrodipicolinate + 2 H2O; dihydrodipicolinate synthase 1771845 dapA 9284315 dapA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydrodipicolinate synthase YP_003688539.1 1771000 R 754252 CDS YP_003688540.1 297626777 9283475 1772025..1772690 1 NC_014215.1 pfam01596, methyltransf_3, O-methyltransferase. Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.; methyltransferase 1772690 9283475 PFREUD_16170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003688540.1 1772025 D 754252 CDS YP_003688541.1 297626778 9282820 complement(1772828..1774075) 1 NC_014215.1 ATP + D-glucose 1-phosphate <=> Pyrophosphate + ADP-glucose; glucose-1-phosphate adenylyltransferase 1774075 glgC 9282820 glgC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glucose-1-phosphate adenylyltransferase YP_003688541.1 1772828 R 754252 CDS YP_003688542.1 297626779 9283614 1774173..1775390 1 NC_014215.1 ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase; glycosyltransferase 1775390 glgA 9283614 glgA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyltransferase YP_003688542.1 1774173 D 754252 CDS YP_003688543.1 297626780 9283612 complement(1775569..1775736) 1 NC_014215.1 hypothetical protein 1775736 9283612 PFREUD_16200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688543.1 1775569 R 754252 CDS YP_003688544.1 297626781 9282821 complement(1775796..1776188) 1 NC_014215.1 hypothetical protein 1776188 9282821 PFREUD_16210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688544.1 1775796 R 754252 CDS YP_003688545.1 297626782 9282822 complement(1776211..1777659) 1 NC_014215.1 chloride channel 1777659 9282822 PFREUD_16220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chloride channel YP_003688545.1 1776211 R 754252 CDS YP_003688546.1 297626783 9282823 complement(1777751..1778593) 1 NC_014215.1 Possible lysine decarboxylase. The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear; lysine decarboxylase 1778593 9282823 PFREUD_16230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lysine decarboxylase YP_003688546.1 1777751 R 754252 CDS YP_003688547.1 297626784 9282824 complement(1778749..1779837) 1 NC_014215.1 N-Succinyl-LL-2,6-diaminoheptanedioate + H2O <=> succinate + LL-2,6-diaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1779837 dapE2 9282824 dapE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 succinyl-diaminopimelate desuccinylase YP_003688547.1 1778749 R 754252 CDS YP_003688548.1 297626785 9283479 1779937..1780875 1 NC_014215.1 Succinyl-CoA + 2,3,4,5-Tetrahydrodipicolinate + H2O <=> CoA + N-Succinyl-2-L-amino-6-oxoheptanedioate; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 1780875 dapD 9283479 dapD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_003688548.1 1779937 D 754252 CDS YP_003688549.1 297626786 9283477 1780882..1781727 1 NC_014215.1 hypothetical protein 1781727 9283477 PFREUD_16260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688549.1 1780882 D 754252 CDS YP_003688550.1 297626787 9282825 complement(1781755..1782846) 1 NC_014215.1 Molecular function: transaminase activity; aminotransferase 1782846 9282825 PFREUD_16270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminotransferase YP_003688550.1 1781755 R 754252 CDS YP_003688551.1 297626788 9282826 complement(1782843..1783163) 1 NC_014215.1 Ferredoxin 1783163 fdxA 9282826 fdxA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ferredoxin YP_003688551.1 1782843 R 754252 CDS YP_003688552.1 297626789 9283545 1783399..1784367 1 NC_014215.1 glycolate + NAD+ = glyoxylate + NADH. _ glycolate + NAD+ <=> Glyoxylate + NADH + H+; glyoxylate reductase 1784367 gya 9283545 gya Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glyoxylate reductase YP_003688552.1 1783399 D 754252 CDS YP_003688553.1 297626790 9283679 1784531..1785955 1 NC_014215.1 (S)-Malate <=> Fumarate + H2O; fumarate hydratase class II 1785955 fumC 9283679 fumC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 fumarate hydratase class II YP_003688553.1 1784531 D 754252 CDS YP_003688554.1 297626791 9283586 1786119..1786565 1 NC_014215.1 hypothetical protein 1786565 9283586 PFREUD_16310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688554.1 1786119 D 754252 CDS YP_003688555.1 297626792 9282827 1786693..1788162 1 NC_014215.1 L-aspartate = fumarate + NH3.; aspartate ammonia-lyase 1788162 aspA1 9282827 aspA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate ammonia-lyase YP_003688555.1 1786693 D 754252 CDS YP_003688556.1 297626793 9283360 1788489..1789961 1 NC_014215.1 L-aspartate <=> Fumarate + NH3; aspartate ammonia-lyase 1789961 aspA2 9283360 aspA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate ammonia-lyase YP_003688556.1 1788489 D 754252 CDS YP_003688557.1 297626794 9283361 1789966..1791261 1 NC_014215.1 C4-dicarboxylate transporter 1791261 dcuA 9283361 dcuA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 C4-dicarboxylate transporter YP_003688557.1 1789966 D 754252 CDS YP_003688558.1 297626795 9283483 complement(1791363..1792166) 1 NC_014215.1 integrase 1792166 int 9283483 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003688558.1 1791363 R 754252 CDS YP_003688559.1 297626796 9283772 complement(1792229..1792513) 1 NC_014215.1 transposase IS3/IS911 1792513 tnpA 9283772 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003688559.1 1792229 R 754252 CDS YP_003688560.1 297626797 9284375 complement(1792609..1793946) 1 NC_014215.1 Bacterial protein of unknown function (DUF894). This family consists of several bacterial proteins, many of which are annotated as putative transmembrane transport proteins.; Integral membrane efflux protein 1793946 pimH 9284375 pimH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Integral membrane efflux protein YP_003688560.1 1792609 R 754252 CDS YP_003688561.1 297626798 9284074 complement(1793943..1794488) 1 NC_014215.1 Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor MarR. A large number of compounds induce transcription of mar operon, due to the compound binding to MarR and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds.; MarR family transcriptional regulator 1794488 9284074 PFREUD_16360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MarR family transcriptional regulator YP_003688561.1 1793943 R 754252 CDS YP_003688562.1 297626799 9282828 1794629..1795141 1 NC_014215.1 acetyltransferase 1795141 9282828 PFREUD_16370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688562.1 1794629 D 754252 CDS YP_003688563.1 297626800 9282829 1795201..1795707 1 NC_014215.1 purine phosphoribosyltransferase 1795707 gpt 9282829 gpt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 purine phosphoribosyltransferase YP_003688563.1 1795201 D 754252 CDS YP_003688564.1 297626801 9283658 complement(1795793..1797052) 1 NC_014215.1 J. Bacteriol. 177:5561-5566(1995).; carboxypeptidase 1797052 cpsA2 9283658 cpsA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxypeptidase YP_003688564.1 1795793 R 754252 CDS YP_003688565.1 297626802 9283446 1797123..1798286 1 NC_014215.1 hypothetical protein 1798286 9283446 PFREUD_16400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688565.1 1797123 D 754252 CDS YP_003688566.1 297626803 9282830 complement(1798377..1799423) 1 NC_014215.1 diacylglycerol kinase, catalytic region 1799423 9282830 PFREUD_16410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 diacylglycerol kinase, catalytic region YP_003688566.1 1798377 R 754252 CDS YP_003688567.1 297626804 9282831 1799877..1800845 1 NC_014215.1 formation of cysteine from O-acetyl-serine and hydrogen sulfide. O3-acetyl-L-serine + H2S = L-cysteine + acetate.; cysteine synthase 1800845 cys2 9282831 cys2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cysteine synthase YP_003688567.1 1799877 D 754252 CDS YP_003688568.1 297626805 9283459 1801065..1802033 1 NC_014215.1 hypothetical protein 1802033 9283459 PFREUD_16430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688568.1 1801065 D 754252 CDS YP_003688569.1 297626806 9282832 complement(1802318..1803595) 1 NC_014215.1 cyanate MSF transporter 1803595 cynX 9282832 cynX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cyanate MSF transporter YP_003688569.1 1802318 R 754252 CDS YP_003688570.1 297626807 9283456 complement(1803743..1804642) 1 NC_014215.1 glycine/betaine ABC transporter 1804642 9283456 PFREUD_16450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine/betaine ABC transporter YP_003688570.1 1803743 R 754252 CDS YP_003688571.1 297626808 9282833 complement(1804680..1805393) 1 NC_014215.1 hypothetical protein 1805393 9282833 PFREUD_16460 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688571.1 1804680 R 754252 CDS YP_003688572.1 297626809 9282834 1805494..1806387 1 NC_014215.1 S-adenosyl-L-methionine + 3-demethylubiquinone-9 <=> S-adenosyl-L-homocysteine + ubiquinone-9; 3-demethylubiquinone-9 3-methyltransferase 1806387 ubiG 9282834 ubiG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-demethylubiquinone-9 3-methyltransferase YP_003688572.1 1805494 D 754252 CDS YP_003688573.1 297626810 9284449 1806589..1808358 1 NC_014215.1 major facilitator superfamily protein 1808358 9284449 PFREUD_16480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 major facilitator superfamily protein YP_003688573.1 1806589 D 754252 CDS YP_003688574.1 297626811 9282835 complement(1808422..1809540) 1 NC_014215.1 ATP + D-glycerate <=> ADP + 3-phospho-D-glycerate; glycerate kinase 1809540 glxK/garK 9282835 glxK/garK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerate kinase YP_003688574.1 1808422 R 754252 CDS YP_003688575.1 297626812 9283642 1809913..1812309 1 NC_014215.1 peptide utilization during carbon starvation. Molecular and functional characterization of a carbon starvation gene of Escherichia coli. (J. Mol. Biol. 218:129-140(1991)); carbon starvation protein 1812309 cstA 9283642 cstA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbon starvation protein YP_003688575.1 1809913 D 754252 CDS YP_003688576.1 297626813 9283450 1812299..1812514 1 NC_014215.1 hypothetical protein 1812514 9283450 PFREUD_16510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688576.1 1812299 D 754252 CDS YP_003688577.1 297626814 9282836 complement(1812518..1813438) 1 NC_014215.1 LysR family transcriptional regulator 1813438 lysR1 9282836 lysR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LysR family transcriptional regulator YP_003688577.1 1812518 R 754252 CDS YP_003688578.1 297626815 9283843 1813508..1814590 1 NC_014215.1 hypothetical protein 1814590 9283843 PFREUD_16530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688578.1 1813508 D 754252 CDS YP_003688579.1 297626816 9282837 complement(1814639..1815880) 1 NC_014215.1 Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family.; UBA/THIF-type NAD/FAD binding protein 1815880 moe 9282837 moe Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UBA/THIF-type NAD/FAD binding protein YP_003688579.1 1814639 R 754252 CDS YP_003688580.1 297626817 9283900 complement(1815877..1816707) 1 NC_014215.1 ThiG, Thiazole biosynthesis protein ThiG. This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway; thiazole biosynthesis protein 1816707 thiG 9283900 thiG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiazole biosynthesis protein YP_003688580.1 1815877 R 754252 CDS YP_003688581.1 297626818 9284333 complement(1816710..1816943) 1 NC_014215.1 ThiS (ThiaminS) is a sulfur carrier protein involved in thiamin biosynthesis in bacteria. The ThiS fold, like those of two closely related proteins MoaD and Urm1, is similar to that of ubiquitin although there is little or no sequence similarity.; thiamine biosynthesis protein 1816943 thiS 9284333 thiS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine biosynthesis protein YP_003688581.1 1816710 R 754252 CDS YP_003688582.1 297626819 9284336 complement(1816940..1818193) 1 NC_014215.1 DadA, glycine/D-amino acid oxidases 1818193 dadA1 9284336 dadA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DadA, glycine/D-amino acid oxidases YP_003688582.1 1816940 R 754252 CDS YP_003688583.1 297626820 9283473 1818369..1819016 1 NC_014215.1 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphoethyl)-thiazole <=> Pyrophosphate + Thiamin monophosphate; thiamine-phosphate pyrophosphorylase 1819016 thiE2 9283473 thiE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine-phosphate pyrophosphorylase YP_003688583.1 1818369 D 754252 CDS YP_003688584.1 297626821 9284332 1819531..1819704 1 NC_014215.1 hypothetical protein 1819704 9284332 PFREUD_16590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688584.1 1819531 D 754252 CDS YP_003688585.1 297626822 9282838 1819701..1820864 1 NC_014215.1 hypothetical protein 1820864 9282838 PFREUD_16600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688585.1 1819701 D 754252 CDS YP_003688586.1 297626823 9282839 complement(1820947..1821990) 1 NC_014215.1 ACR3, arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism].; arsenite efflux pump permease 1821990 9282839 PFREUD_16610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arsenite efflux pump permease YP_003688586.1 1820947 R 754252 CDS YP_003688588.1 297626825 9282842 1822551..1822625 1 NC_014215.1 hypothetical protein 1822625 9282842 PFREUD_16640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688588.1 1822551 D 754252 CDS YP_003688589.1 297626826 9282843 1822592..1823899 1 NC_014215.1 transposase 1823899 tnpA 9282843 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688589.1 1822592 D 754252 CDS YP_003688590.1 297626827 9282844 complement(1824308..1825216) 1 NC_014215.1 integrase 1825216 int 9282844 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003688590.1 1824308 R 754252 CDS YP_003688591.1 297626828 9283773 complement(1825213..1825518) 1 NC_014215.1 transposase IS3/IS911 1825518 tnpC 9283773 tnpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003688591.1 1825213 R 754252 CDS YP_003688592.1 297626829 9283630 1826611..1828143 1 NC_014215.1 acylglycerone phosphate + Long-subunit alcohol <=> O-Alkylglycerone phosphate + Long-subunit acid anion; alkylglycerone-phosphate synthase 1828143 9283630 PFREUD_16670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alkylglycerone-phosphate synthase YP_003688592.1 1826611 D 754252 CDS YP_003688593.1 297626830 9282845 1828232..1828891 1 NC_014215.1 In the presence of glycerol 3-phosphate, this protein is thought to enhance transcription; transcriptional regulator 1828891 9282845 PFREUD_16680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688593.1 1828232 D 754252 CDS YP_003688594.1 297626831 9282846 1828864..1829124 1 NC_014215.1 hypothetical protein 1829124 9282846 PFREUD_16690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688594.1 1828864 D 754252 CDS YP_003688595.1 297626832 9282847 complement(1829229..1830338) 1 NC_014215.1 transposase 1830338 tnpA 9282847 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688595.1 1829229 R 754252 CDS YP_003688596.1 297626833 9284377 1830378..1830836 1 NC_014215.1 hypothetical protein 1830836 9284377 PFREUD_16700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688596.1 1830378 D 754252 CDS YP_003688597.1 297626834 9282848 1830990..1832705 1 NC_014215.1 (R)-Lactate + NAD+ <=> pyruvate + NADH + H+; d-lactate dehydrogenase 1832705 dld 9282848 dld Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 d-lactate dehydrogenase YP_003688597.1 1830990 D 754252 CDS YP_003688598.1 297626835 9283503 1833079..1833699 1 NC_014215.1 transposase for IS3514b 1833699 9283503 PFREUD_24800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase for IS3514b YP_003688598.1 1833079 D 754252 CDS YP_003688599.1 297626836 9283281 complement(1833845..1834141) 1 NC_014215.1 transposase 1834141 9283281 PFREUD_24820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688599.1 1833845 R 754252 CDS YP_003688600.1 297626837 9283282 complement(1834164..1835363) 1 NC_014215.1 integrase 1835363 int 9283282 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003688600.1 1834164 R 754252 CDS YP_003688601.1 297626838 9283774 complement(1835305..1836327) 1 NC_014215.1 transposase 1836327 tnp 9283774 tnp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688601.1 1835305 R 754252 CDS YP_003688602.1 297626839 9284349 complement(1836327..1836638) 1 NC_014215.1 transposase IS3/IS911 1836638 tnpD 9284349 tnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003688602.1 1836327 R 754252 CDS YP_003688603.1 297626840 9284410 1836899..1837945 1 NC_014215.1 hypothetical protein 1837945 9284410 PFREUD_16720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688603.1 1836899 D 754252 CDS YP_003688604.1 297626841 9282849 complement(1837949..1838383) 1 NC_014215.1 Molecular function: transcription factor activity, Biological process: regulation of transcription, DNA-dependent; excisionase 1838383 9282849 PFREUD_16730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 excisionase YP_003688604.1 1837949 R 754252 CDS YP_003688605.1 297626842 9282850 complement(1838663..1838884) 1 NC_014215.1 hypothetical protein 1838884 9282850 PFREUD_16740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688605.1 1838663 R 754252 CDS YP_003688606.1 297626843 9282851 1838930..1839829 1 NC_014215.1 transposase 1839829 tnpA 9282851 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688606.1 1838930 D 754252 CDS YP_003688608.1 297626845 9282852 complement(1839962..1840657) 1 NC_014215.1 protein-disulfide isomerase 1840657 frnE 9282852 frnE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein-disulfide isomerase YP_003688608.1 1839962 R 754252 CDS YP_003688609.1 297626846 9283575 complement(1840657..1840860) 1 NC_014215.1 hypothetical protein 1840860 9283575 PFREUD_16770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688609.1 1840657 R 754252 CDS YP_003688610.1 297626847 9282853 complement(1841064..1842302) 1 NC_014215.1 major facilitator super family protein 1842302 9282853 PFREUD_16780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 major facilitator super family protein YP_003688610.1 1841064 R 754252 CDS YP_003688611.1 297626848 9282854 1842373..1843338 1 NC_014215.1 LysR family transcriptional regulator 1843338 lysR2 9282854 lysR2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LysR family transcriptional regulator YP_003688611.1 1842373 D 754252 CDS YP_003688612.1 297626849 9283844 complement(1843302..1844072) 1 NC_014215.1 hypothetical protein 1844072 9283844 PFREUD_16800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688612.1 1843302 R 754252 CDS YP_003688613.1 297626850 9282855 1843723..1843806 1 NC_014215.1 hypothetical protein 1843806 9282855 PFREUD_16810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688613.1 1843723 D 754252 CDS YP_003688615.1 297626852 9282857 complement(1844166..1845275) 1 NC_014215.1 hypothetical protein 1845275 9282857 PFREUD_16830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688615.1 1844166 R 754252 CDS YP_003688616.1 297626853 9282858 complement(1845275..1845499) 1 NC_014215.1 hypothetical protein 1845499 9282858 PFREUD_16840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688616.1 1845275 R 754252 CDS YP_003688617.1 297626854 9282859 1845605..1845964 1 NC_014215.1 hypothetical protein 1845964 9282859 PFREUD_16850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688617.1 1845605 D 754252 CDS YP_003688618.1 297626855 9282860 complement(1846287..1846844) 1 NC_014215.1 hypothetical protein 1846844 9282860 PFREUD_16860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688618.1 1846287 R 754252 CDS YP_003688619.1 297626856 9282861 1847067..1847318 1 NC_014215.1 hypothetical protein 1847318 9282861 PFREUD_16870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688619.1 1847067 D 754252 CDS YP_003688620.1 297626857 9282862 1847423..1847980 1 NC_014215.1 hypothetical protein 1847980 9282862 PFREUD_16880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688620.1 1847423 D 754252 CDS YP_003688621.1 297626858 9282863 1847986..1848849 1 NC_014215.1 peptidase 1848849 9282863 PFREUD_16890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase YP_003688621.1 1847986 D 754252 CDS YP_003688622.1 297626859 9282864 1848865..1848951 1 NC_014215.1 hypothetical protein 1848951 9282864 PFREUD_16900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688622.1 1848865 D 754252 CDS YP_003688623.1 297626860 9282865 complement(1848955..1849473) 1 NC_014215.1 hypothetical protein 1849473 9282865 PFREUD_16910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688623.1 1848955 R 754252 CDS YP_003688624.1 297626861 9282866 complement(1849626..1851452) 1 NC_014215.1 hypothetical protein 1851452 9282866 PFREUD_16920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688624.1 1849626 R 754252 CDS YP_003688625.1 297626862 9282867 complement(1851554..1852645) 1 NC_014215.1 GTPase YchF 1852645 ychF 9282867 ychF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTPase YchF YP_003688625.1 1851554 R 754252 CDS YP_003688626.1 297626863 9284487 complement(1852740..1854002) 1 NC_014215.1 aminopeptidase 1854002 apeB 9284487 apeB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminopeptidase YP_003688626.1 1852740 R 754252 CDS YP_003688627.1 297626864 9283315 1854161..1855510 1 NC_014215.1 RmuC family. This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures; DNA recombination protein 1855510 rmuC 9283315 rmuC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA recombination protein YP_003688627.1 1854161 D 754252 CDS YP_003688628.1 297626865 9284188 1855293..1855817 1 NC_014215.1 No TM domain, no signal peptide; hypothetical protein 1855817 9284188 PFREUD_16960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688628.1 1855293 D 754252 CDS YP_003688629.1 297626866 9282868 complement(1855442..1856431) 1 NC_014215.1 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + NADPH + H+ <=> Isopentenyl diphosphate + NADP+ + H2O / Dimethylallyl diphosphate + NADP+ + H2O <=> 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate + NADPH + H+; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1856431 ispH 9282868 ispH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_003688629.1 1855442 R 754252 CDS YP_003688630.1 297626867 9283797 1856475..1857848 1 NC_014215.1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. Exonucleolytic cleavage in either 5 prime- to 3 prime- or 3 prime- to 5 prime-direction to yield nucleoside 5 prime-phosphates.Heterooligomer composed of large and small subunits; exodeoxyribonuclease VII large subunit 1857848 xseA 9283797 xseA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exodeoxyribonuclease VII large subunit YP_003688630.1 1856475 D 754252 CDS YP_003688631.1 297626868 9284479 1857896..1858138 1 NC_014215.1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. Exonucleolytic cleavage in either 5 prime- to 3 prime- or 3 prime- to 5 prime-direction to yield nucleoside 5 prime-phosphates.Heterooligomer composed of large and small subunits; exodeoxyribonuclease 7 small subunit 1858138 xseB 9284479 xseB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 exodeoxyribonuclease 7 small subunit YP_003688631.1 1857896 D 754252 CDS YP_003688632.1 297626869 9284480 complement(1858183..1858920) 1 NC_014215.1 hypothetical protein 1858920 9284480 PFREUD_17000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688632.1 1858183 R 754252 CDS YP_003688633.1 297626870 9282869 1859119..1859928 1 NC_014215.1 trans,trans,cis-Geranylgeranyl diphosphate + 7 Isopentenyl diphosphate <=> di-trans,poly-cis-UDP diphosphate + 7 Pyrophosphate and di-trans,poly-cis-Decaprenyl diphosphate + Isopentenyl diphosphate <=> Pyrophosphate + di-trans,poly-cis-UDP diphosphate; UDP pyrophosphate synthase 1859928 uppS 9282869 uppS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP pyrophosphate synthase YP_003688633.1 1859119 D 754252 CDS YP_003688634.1 297626871 9284459 complement(1859941..1860459) 1 NC_014215.1 hypothetical protein 1860459 9284459 PFREUD_17020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688634.1 1859941 R 754252 CDS YP_003688635.1 297626872 9282870 complement(1860497..1863181) 1 NC_014215.1 thioredoxin 1863181 PPA0563 9282870 PPA0563 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin YP_003688635.1 1860497 R 754252 CDS YP_003688636.1 297626873 9284095 complement(1863354..1864280) 1 NC_014215.1 LMBE-related protein 1864280 9284095 PFREUD_17040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LMBE-related protein YP_003688636.1 1863354 R 754252 CDS YP_003688637.1 297626874 9282871 1864375..1864878 1 NC_014215.1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases, resulting in locked ternary complexes. Cleavage of the nascent transcript by greA or greB allows the resumption of elongation from the new 3primeterminus.; transcription elongation factor GreA 1864878 greA 9282871 greA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription elongation factor GreA YP_003688637.1 1864375 D 754252 CDS YP_003688638.1 297626875 9283659 1864965..1865417 1 NC_014215.1 hypothetical protein 1865417 9283659 PFREUD_17060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688638.1 1864965 D 754252 CDS YP_003688639.1 297626876 9282872 complement(1865533..1866495) 1 NC_014215.1 hypothetical protein 1866495 9282872 PFREUD_17070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688639.1 1865533 R 754252 CDS YP_003688640.1 297626877 9282873 complement(1866581..1868011) 1 NC_014215.1 hypothetical protein 1868011 9282873 PFREUD_17080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688640.1 1866581 R 754252 CDS YP_003688641.1 297626878 9282874 1868192..1868881 1 NC_014215.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1868881 ung 9282874 ung Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 uracil-DNA glycosylase YP_003688641.1 1868192 D 754252 CDS YP_003688642.1 297626879 9284456 1868993..1869628 1 NC_014215.1 peptide-L-methionine + Oxidized thioredoxin + H2O <=> peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + Oxidized thioredoxin + H2O <=> L-methionine (S)-S-oxide + thioredoxin; peptide-methionine (S)-S-oxide reductase 1869628 msrA 9284456 msrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptide-methionine (S)-S-oxide reductase YP_003688642.1 1868993 D 754252 CDS YP_003688643.1 297626880 9283913 1869748..1870278 1 NC_014215.1 hypothetical protein 1870278 9283913 PFREUD_17110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688643.1 1869748 D 754252 CDS YP_003688644.1 297626881 9282875 complement(1870383..1871030) 1 NC_014215.1 hypothetical protein 1871030 9282875 PFREUD_17120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688644.1 1870383 R 754252 CDS YP_003688645.1 297626882 9282876 1871208..1871822 1 NC_014215.1 Hydrolase 1871822 9282876 PFREUD_17130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Hydrolase YP_003688645.1 1871208 D 754252 CDS YP_003688646.1 297626883 9282877 1871819..1872325 1 NC_014215.1 hypothetical protein 1872325 9282877 PFREUD_17140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688646.1 1871819 D 754252 CDS YP_003688647.1 297626884 9282878 complement(1872351..1872806) 1 NC_014215.1 hypothetical protein 1872806 9282878 PFREUD_17150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688647.1 1872351 R 754252 CDS YP_003688648.1 297626885 9282879 complement(1872940..1873344) 1 NC_014215.1 hypothetical protein 1873344 9282879 PFREUD_17160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688648.1 1872940 R 754252 CDS YP_003688649.1 297626886 9282880 complement(1873357..1873446) 1 NC_014215.1 hypothetical protein 1873446 9282880 PFREUD_17170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688649.1 1873357 R 754252 CDS YP_003688650.1 297626887 9282881 complement(1873474..1874124) 1 NC_014215.1 methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.; 3-methyladenine DNA glycosylase 1874124 mpg 9282881 mpg Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-methyladenine DNA glycosylase YP_003688650.1 1873474 R 754252 CDS YP_003688651.1 297626888 9283905 1874333..1875283 1 NC_014215.1 hypothetical protein 1875283 9283905 PFREUD_17190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688651.1 1874333 D 754252 CDS YP_003688652.1 297626889 9282882 1875332..1876036 1 NC_014215.1 NUDIX hydrolase 1876036 9282882 PFREUD_17200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003688652.1 1875332 D 754252 CDS YP_003688653.1 297626890 9282883 complement(1876211..1877023) 1 NC_014215.1 hypothetical protein 1877023 9282883 PFREUD_17210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688653.1 1876211 R 754252 CDS YP_003688654.1 297626891 9282884 complement(1877160..1877909) 1 NC_014215.1 methyltransferase 1877909 9282884 PFREUD_17220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003688654.1 1877160 R 754252 CDS YP_003688655.1 297626892 9282885 1878212..1878985 1 NC_014215.1 nucleoside-diphosphate-sugar epimerase 1878985 9282885 PFREUD_17230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nucleoside-diphosphate-sugar epimerase YP_003688655.1 1878212 D 754252 CDS YP_003688656.1 297626893 9282886 1879202..1880665 1 NC_014215.1 amino acid ABC transporter permease 1880665 9282886 PFREUD_17240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003688656.1 1879202 D 754252 CDS YP_003688657.1 297626894 9282887 complement(1880723..1881994) 1 NC_014215.1 2-phospho-D-glycerate = phosphoenolpyruvate + H2O, homodimer, cofactor : magnesium; enolase 1881994 eno2 9282887 eno2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 enolase YP_003688657.1 1880723 R 754252 CDS YP_003688658.1 297626895 9283536 complement(1882285..1882923) 1 NC_014215.1 tetR-family transcriptional regulator 1882923 9283536 PFREUD_17260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tetR-family transcriptional regulator YP_003688658.1 1882285 R 754252 CDS YP_003688659.1 297626896 9282888 1882988..1884415 1 NC_014215.1 transmembrane efflux protein 1884415 9282888 PFREUD_17270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transmembrane efflux protein YP_003688659.1 1882988 D 754252 CDS YP_003688660.1 297626897 9282890 complement(1884681..1885637) 1 NC_014215.1 Guanosine 3prime-diphosphate 5prime-triphosphate + H2O <=> Guanosine 3prime,5prime-bis(diphosphate) + Orthophosphate; Ppx/GppA phosphatase 1885637 ppx 9282890 ppx Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ppx/GppA phosphatase YP_003688660.1 1884681 R 754252 CDS YP_003688661.1 297626898 9284113 complement(1885634..1886149) 1 NC_014215.1 hypothetical protein 1886149 9284113 PFREUD_17300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688661.1 1885634 R 754252 CDS YP_003688662.1 297626899 9282891 complement(1886229..1886870) 1 NC_014215.1 hypothetical protein 1886870 9282891 PFREUD_17310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688662.1 1886229 R 754252 CDS YP_003688663.1 297626900 9282892 complement(1887148..1888437) 1 NC_014215.1 2-phospho-D-glycerate = phosphoenolpyruvate + H2O, homodimer, cofactor : magnesium; enolase 1888437 eno1 9282892 eno1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 enolase YP_003688663.1 1887148 R 754252 CDS YP_003688664.1 297626901 9283535 complement(1888552..1889223) 1 NC_014215.1 MazG family transcriptional regulator 1889223 9283535 PFREUD_17330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MazG family transcriptional regulator YP_003688664.1 1888552 R 754252 CDS YP_003688665.1 297626902 9282893 complement(1889223..1889756) 1 NC_014215.1 hypothetical protein 1889756 9282893 PFREUD_17340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688665.1 1889223 R 754252 CDS YP_003688666.1 297626903 9282894 complement(1889878..1893576) 1 NC_014215.1 Necessary for strand-specific repair. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognized by TRCF which releases RNAP and the truncated transcript; the TCRF may replace RNAP at the lesion site and then recruit the uvrA/B/C repair system; transcription-repair coupling factor 1893576 mfd 9282894 mfd Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription-repair coupling factor YP_003688666.1 1889878 R 754252 CDS YP_003688667.1 297626904 9283883 complement(1893652..1894017) 1 NC_014215.1 hypothetical protein 1894017 9283883 PFREUD_17360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688667.1 1893652 R 754252 CDS YP_003688668.1 297626905 9282895 complement(1894085..1894678) 1 NC_014215.1 N-Substituted aminoacyl-tRNA + H2O <=> N-Substituted amino acid + tRNA; peptidyl-tRNA hydrolase 1894678 pth 9282895 pth Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidyl-tRNA hydrolase YP_003688668.1 1894085 R 754252 CDS YP_003688670.1 297626907 9282896 complement(1894883..1895542) 1 NC_014215.1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18; 50S ribosomal protein L25 1895542 rplY 9282896 rplY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L25 YP_003688670.1 1894883 R 754252 CDS YP_003688671.1 297626908 9284221 complement(1895920..1896915) 1 NC_014215.1 ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate; ribose-phosphate pyrophosphokinase 1896915 prs 9284221 prs Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribose-phosphate pyrophosphokinase YP_003688671.1 1895920 R 754252 CDS YP_003688672.1 297626909 9284126 complement(1896949..1898496) 1 NC_014215.1 UTP + N-acetyl-D-glucosamine 1-phosphate <=> Pyrophosphate + UDP-N-acetyl-D-glucosamine and UTP + N-acetyl-alpha-D-glucosamine 1-phosphate <=> Pyrophosphate + UDP-N-acetyl-D-glucosamine; UDP-N-acetylglucosamine pyrophosphorylase 1898496 glmU 9284126 glmU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-N-acetylglucosamine pyrophosphorylase YP_003688672.1 1896949 R 754252 CDS YP_003688673.1 297626910 9283621 complement(1898574..1898675) 1 NC_014215.1 hypothetical protein 1898675 9283621 PFREUD_17420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688673.1 1898574 R 754252 CDS YP_003688674.1 297626911 9282898 1898923..1899969 1 NC_014215.1 carbamoyl phosphate + L-aspartate <=> Orthophosphate + N-carbamoyl-L-aspartate; aspartate carbamoyltransferase 1899969 pyrB 9282898 pyrB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate carbamoyltransferase YP_003688674.1 1898923 D 754252 CDS YP_003688675.1 297626912 9284152 1900064..1900873 1 NC_014215.1 TetR family transcriptional regulator 1900873 tetR7 9284152 tetR7 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003688675.1 1900064 D 754252 CDS YP_003688676.1 297626913 9284326 complement(1900908..1901885) 1 NC_014215.1 4-(Cytidine 5prime-diphospho)-2-C-methyl-D-erythritol + ATP <=> 2-phospho-4-(cytidine 5prime-diphospho)-2-C-methyl-D-erythritol + ADP; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1901885 ispE 9284326 ispE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_003688676.1 1900908 R 754252 CDS YP_003688677.1 297626914 9283794 complement(1901962..1902831) 1 NC_014215.1 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3prime-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance; dimethyladenosine transferase 1902831 ksgA 9283794 ksgA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dimethyladenosine transferase YP_003688677.1 1901962 R 754252 CDS YP_003688678.1 297626915 9283803 complement(1902828..1903856) 1 NC_014215.1 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.; DNAse 1903856 tatD 9283803 tatD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNAse YP_003688678.1 1902828 R 754252 CDS YP_003688679.1 297626916 9284317 complement(1903989..1904867) 1 NC_014215.1 pfam00590, TP_methylase, Tetrapyrrole (Corrin/Porphyrin) methylases. This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function. This family includes the methylase Dipthine synthase.; methylase 1904867 9284317 PFREUD_17490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylase YP_003688679.1 1903989 R 754252 CDS YP_003688680.1 297626917 9282899 complement(1904953..1907340) 1 NC_014215.1 hypothetical protein 1907340 9282899 PFREUD_17500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688680.1 1904953 R 754252 CDS YP_003688681.1 297626918 9282900 1907552..1909186 1 NC_014215.1 glycosyl transferase family protein 1909186 9282900 PFREUD_17510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyl transferase family protein YP_003688681.1 1907552 D 754252 CDS YP_003688682.1 297626919 9282901 1909236..1910300 1 NC_014215.1 hypothetical protein 1910300 9282901 PFREUD_17520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688682.1 1909236 D 754252 CDS YP_003688683.1 297626920 9282902 1910422..1911972 1 NC_014215.1 Pyrimidine permease RutG (Pyrimidine utilization protein G) 1911972 rutG 9282902 rutG Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Pyrimidine permease RutG (Pyrimidine utilization protein G) YP_003688683.1 1910422 D 754252 CDS YP_003688684.1 297626921 9284256 complement(1912003..1912524) 1 NC_014215.1 hypothetical protein 1912524 9284256 PFREUD_17540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688684.1 1912003 R 754252 CDS YP_003688685.1 297626922 9282903 1912705..1912791 1 NC_014215.1 hypothetical protein 1912791 9282903 PFREUD_17550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688685.1 1912705 D 754252 CDS YP_003688686.1 297626923 9282904 1912788..1913984 1 NC_014215.1 ATP + D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate; galactokinase 1913984 galK1 9282904 galK1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 galactokinase YP_003688686.1 1912788 D 754252 CDS YP_003688687.1 297626924 9283595 1914141..1914674 1 NC_014215.1 The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents; Stress protein 1914674 usp 9283595 usp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Stress protein YP_003688687.1 1914141 D 754252 CDS YP_003688688.1 297626925 9284462 1914671..1915087 1 NC_014215.1 CRCB is a putative integral membrane protein possibly involved in chromosome condensation. Over expression in E. Coli also leads to camphor resistance.; hypothetical protein 1915087 9284462 PFREUD_17580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688688.1 1914671 D 754252 CDS YP_003688689.1 297626926 9282905 1915084..1915470 1 NC_014215.1 hypothetical protein 1915470 9282905 PFREUD_17590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688689.1 1915084 D 754252 CDS YP_003688690.1 297626927 9282906 1915530..1916003 1 NC_014215.1 acetyltransferase 1916003 9282906 PFREUD_17600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003688690.1 1915530 D 754252 CDS YP_003688691.1 297626928 9282907 complement(1916123..1917487) 1 NC_014215.1 L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH. Homohexamer (By similarity). Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Evidenced as a heat stress proetin in P. freudenreichii; glutamate dehydrogenase 1917487 gdh 9282907 gdh Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate dehydrogenase YP_003688691.1 1916123 R 754252 CDS YP_003688692.1 297626929 9283608 complement(1917642..1918886) 1 NC_014215.1 multidrug MFS transporter 1918886 9283608 PFREUD_17620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 multidrug MFS transporter YP_003688692.1 1917642 R 754252 CDS YP_003688693.1 297626930 9282908 1918906..1919166 1 NC_014215.1 hypothetical protein 1919166 9282908 PFREUD_17630 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688693.1 1918906 D 754252 CDS YP_003688694.1 297626931 9282909 1918928..1919221 1 NC_014215.1 hypothetical protein 1919221 9282909 PFREUD_17640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688694.1 1918928 D 754252 CDS YP_003688695.1 297626932 9282910 1919273..1919866 1 NC_014215.1 TetR family transcriptional regulator 1919866 tetR8 9282910 tetR8 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003688695.1 1919273 D 754252 CDS YP_003688696.1 297626933 9284327 complement(1919942..1921381) 1 NC_014215.1 Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response; proline/betaine transporter 1921381 proP 9284327 proP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 proline/betaine transporter YP_003688696.1 1919942 R 754252 CDS YP_003688697.1 297626934 9284120 complement(1921520..1922953) 1 NC_014215.1 permease 1922953 9284120 PFREUD_17670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 permease YP_003688697.1 1921520 R 754252 CDS YP_003688698.1 297626935 9282911 complement(1923026..1923430) 1 NC_014215.1 transcriptional regulator 1923430 arsR5 9282911 arsR5 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688698.1 1923026 R 754252 CDS YP_003688699.1 297626936 9283352 complement(1923414..1923848) 1 NC_014215.1 MarR family transcriptional regulator 1923848 marR3 9283352 marR3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MarR family transcriptional regulator YP_003688699.1 1923414 R 754252 CDS YP_003688700.1 297626937 9283860 1923912..1924280 1 NC_014215.1 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.; hypothetical protein 1924280 9283860 PFREUD_17700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688700.1 1923912 D 754252 CDS YP_003688701.1 297626938 9282912 complement(1924330..1924983) 1 NC_014215.1 peptidase 1924983 9282912 PFREUD_17710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase YP_003688701.1 1924330 R 754252 CDS YP_003688703.1 297626940 9282914 1925151..1925216 1 NC_014215.1 hypothetical protein 1925216 9282914 PFREUD_17730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688703.1 1925151 D 754252 CDS YP_003688704.1 297626941 9282915 complement(1925287..1926066) 1 NC_014215.1 hypothetical protein 1926066 9282915 PFREUD_17740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688704.1 1925287 R 754252 CDS YP_003688705.1 297626942 9282916 complement(1926229..1926888) 1 NC_014215.1 two-component system, regulatory protein 1926888 9282916 PFREUD_17750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system, regulatory protein YP_003688705.1 1926229 R 754252 CDS YP_003688706.1 297626943 9282917 complement(1926885..1928072) 1 NC_014215.1 sensor kinase-membrane protein 1928072 9282917 PFREUD_17760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sensor kinase-membrane protein YP_003688706.1 1926885 R 754252 CDS YP_003688707.1 297626944 9282918 1928223..1928786 1 NC_014215.1 hypothetical protein 1928786 9282918 PFREUD_17770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688707.1 1928223 D 754252 CDS YP_003688708.1 297626945 9282919 1929022..1929384 1 NC_014215.1 No TM domain, no signal peptide; hypothetical protein 1929384 9282919 PFREUD_17780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688708.1 1929022 D 754252 CDS YP_003688709.1 297626946 9282920 complement(1929387..1929509) 1 NC_014215.1 hypothetical protein 1929509 9282920 PFREUD_17790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688709.1 1929387 R 754252 CDS YP_003688710.1 297626947 9282921 1929602..1929880 1 NC_014215.1 arabinose operon control protein; AraC family transcriptional regulator 1929880 araC2 9282921 araC2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 AraC family transcriptional regulator YP_003688710.1 1929602 D 754252 CDS YP_003688711.1 297626948 9283323 complement(1930285..1930704) 1 NC_014215.1 Binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon; heat shock protein transcriptional repressor HspR1 1930704 hspR1 9283323 hspR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 heat shock protein transcriptional repressor HspR1 YP_003688711.1 1930285 R 754252 CDS YP_003688712.1 297626949 9283727 complement(1930706..1931803) 1 NC_014215.1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins; molecular chaperone DnaJ 1931803 dnaJ1 9283727 dnaJ1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone DnaJ YP_003688712.1 1930706 R 754252 CDS YP_003688713.1 297626950 9283513 complement(1931800..1932369) 1 NC_014215.1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK; molecular chaperone GrpE1 1932369 grpE1 9283513 grpE1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone GrpE1 YP_003688713.1 1931800 R 754252 CDS YP_003688714.1 297626951 9283664 complement(1932530..1934359) 1 NC_014215.1 Belongs to the heat shock protein 70 family. Acts as a chaperone. Several 70 to 75 kda Hsp70 chaperones are expressed as disctinct heat shock proteins; molecular chaperone DnaK 1934359 dnaK1 9283664 dnaK1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone DnaK YP_003688714.1 1932530 R 754252 CDS YP_003688715.1 297626952 9283516 complement(1934513..1934752) 1 NC_014215.1 hypothetical protein 1934752 9283516 PFREUD_17850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688715.1 1934513 R 754252 CDS YP_003688716.1 297626953 9282922 complement(1934739..1935611) 1 NC_014215.1 Trypsin-like serine protease 1935611 htrA1 9282922 htrA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Trypsin-like serine protease YP_003688716.1 1934739 R 754252 CDS YP_003688717.1 297626954 9283729 1935658..1935876 1 NC_014215.1 hypothetical protein 1935876 9283729 PFREUD_17870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688717.1 1935658 D 754252 CDS YP_003688718.1 297626955 9282923 complement(1935893..1936414) 1 NC_014215.1 hypothetical protein 1936414 9282923 PFREUD_17880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688718.1 1935893 R 754252 CDS YP_003688719.1 297626956 9282924 complement(1936637..1937302) 1 NC_014215.1 two-component system response regulator 1937302 9282924 PFREUD_17890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system response regulator YP_003688719.1 1936637 R 754252 CDS YP_003688720.1 297626957 9282925 complement(1937299..1938222) 1 NC_014215.1 two-component system sensor kinase. membrane protein 1938222 9282925 PFREUD_17900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two-component system sensor kinase. membrane protein YP_003688720.1 1937299 R 754252 CDS YP_003688721.1 297626958 9282926 complement(1938346..1939113) 1 NC_014215.1 hypothetical protein 1939113 9282926 PFREUD_17910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688721.1 1938346 R 754252 CDS YP_003688722.1 297626959 9282927 1939480..1942062 1 NC_014215.1 The protein has been identified by proteomics as a 94 kDa protein induced by heat, bile salts and acid stress; ATP-dependent Clp protease B2 1942062 clpB 9282927 clpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease B2 YP_003688722.1 1939480 D 754252 CDS YP_003688723.1 297626960 9283421 complement(1942131..1942865) 1 NC_014215.1 hypothetical protein 1942865 9283421 PFREUD_17930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688723.1 1942131 R 754252 CDS YP_003688724.1 297626961 9282928 complement(1942970..1943395) 1 NC_014215.1 Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; thioredoxin 1943395 trxA5 9282928 trxA5 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin YP_003688724.1 1942970 R 754252 CDS YP_003688725.1 297626962 9282929 1944008..1945510 1 NC_014215.1 recombinase 1945510 9282929 PFREUD_17960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 recombinase YP_003688725.1 1944008 D 754252 CDS YP_003688726.1 297626963 9282931 complement(1945558..1946367) 1 NC_014215.1 hypothetical protein 1946367 9282931 PFREUD_17980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688726.1 1945558 R 754252 CDS YP_003688727.1 297626964 9282932 complement(1946436..1947146) 1 NC_014215.1 acetyl-CoA + ribosomal-protein L-alanine <=> CoA + ribosomal-protein N-acetyl-L-alanine; ribosomal-protein-alanine acetyltransferase 1947146 rimJ 9282932 rimJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribosomal-protein-alanine acetyltransferase YP_003688727.1 1946436 R 754252 CDS YP_003688728.1 297626965 9284180 complement(1947150..1948436) 1 NC_014215.1 Involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes; molybdenum cofactor synthesis protein 1948436 moeA1 9284180 moeA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molybdenum cofactor synthesis protein YP_003688728.1 1947150 R 754252 CDS YP_003688729.1 297626966 9283901 1948455..1949165 1 NC_014215.1 catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+.Dayan A, Bertrand R, Beauchemin M, Chahla D, Mamo A, Filion M, 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin.; 5-formyltetrahydrofolate cyclo-ligase 1949165 ygfA 9283901 ygfA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 5-formyltetrahydrofolate cyclo-ligase YP_003688729.1 1948455 D 754252 CDS YP_003688730.1 297626967 9284489 1949321..1949728 1 NC_014215.1 type I antifreeze protein 1949728 9284489 PFREUD_18020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 type I antifreeze protein YP_003688730.1 1949321 D 754252 CDS YP_003688731.1 297626968 9282933 1949834..1950469 1 NC_014215.1 hypothetical protein 1950469 9282933 PFREUD_18030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688731.1 1949834 D 754252 CDS YP_003688733.1 297626970 9282935 1950550..1951005 1 NC_014215.1 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell; Large conductance mechanosensitive channel 1951005 mscL 9282935 mscL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Large conductance mechanosensitive channel YP_003688733.1 1950550 D 754252 CDS YP_003688734.1 297626971 9283911 complement(1951059..1951469) 1 NC_014215.1 hypothetical protein 1951469 9283911 PFREUD_18060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688734.1 1951059 R 754252 CDS YP_003688735.1 297626972 9282936 complement(1951462..1952835) 1 NC_014215.1 UTP + D-glucose 1-phosphate <=> Pyrophosphate + UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1952835 ugpA 9282936 ugpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UTP-glucose-1-phosphate uridylyltransferase YP_003688735.1 1951462 R 754252 CDS YP_003688736.1 297626973 9282937 1953410..1953742 1 NC_014215.1 hypothetical protein 1953742 9282937 PFREUD_18090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688736.1 1953410 D 754252 CDS YP_003688737.1 297626974 9282938 complement(1953887..1954507) 1 NC_014215.1 an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond.isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.; isochorismatase hydrolase 1954507 9282938 PFREUD_18100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 isochorismatase hydrolase YP_003688737.1 1953887 R 754252 CDS YP_003688738.1 297626975 9282939 complement(1954504..1955313) 1 NC_014215.1 recombinant protein active on 1- naphthyl actetate and 1- naphthyl propionate; carboxylic ester hydrolase 1955313 pf1655 9282939 pf1655 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003688738.1 1954504 R 754252 CDS YP_003688739.1 297626976 9284034 1955465..1955824 1 NC_014215.1 hypothetical protein 1955824 9284034 PFREUD_18120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688739.1 1955465 D 754252 CDS YP_003688741.1 297626978 9282941 complement(1955989..1956324) 1 NC_014215.1 thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise. protein dithiol + NAD+ <=> protein disulfide + NADH + H+; thiredoxine 1956324 trxA4 9282941 trxA4 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiredoxine YP_003688741.1 1955989 R 754252 CDS YP_003688742.1 297626979 9284438 complement(1956440..1957117) 1 NC_014215.1 Iron-dependent repressor 1957117 dtxR 9284438 dtxR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Iron-dependent repressor YP_003688742.1 1956440 R 754252 CDS YP_003688743.1 297626980 9283527 1957294..1958415 1 NC_014215.1 phosphoserine aminotransferase 1958415 serC 9283527 serC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoserine aminotransferase YP_003688743.1 1957294 D 754252 CDS YP_003688744.1 297626981 9284278 complement(1958458..1958895) 1 NC_014215.1 hypothetical protein 1958895 9284278 PFREUD_18170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688744.1 1958458 R 754252 CDS YP_003688745.1 297626982 9282942 complement(1959006..1960568) 1 NC_014215.1 permease 1960568 9282942 PFREUD_18180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 permease YP_003688745.1 1959006 R 754252 CDS YP_003688746.1 297626983 9282943 1960614..1960955 1 NC_014215.1 hypothetical protein 1960955 9282943 PFREUD_18190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688746.1 1960614 D 754252 CDS YP_003688747.1 297626984 9282944 complement(1961033..1961812) 1 NC_014215.1 hypothetical protein 1961812 9282944 PFREUD_18200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688747.1 1961033 R 754252 CDS YP_003688748.1 297626985 9282945 complement(1961816..1962202) 1 NC_014215.1 RNA-binding domain that functions as a RNA-chaperone in bacteria; Cold shock protein 1962202 cspB 9282945 cspB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cold shock protein YP_003688748.1 1961816 R 754252 CDS YP_003688749.1 297626986 9283449 1962456..1963457 1 NC_014215.1 hypothetical protein 1963457 9283449 PFREUD_18220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688749.1 1962456 D 754252 CDS YP_003688750.1 297626987 9282946 1963454..1965829 1 NC_014215.1 hypothetical protein 1965829 9282946 PFREUD_18230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688750.1 1963454 D 754252 CDS YP_003688751.1 297626988 9282947 complement(1965766..1967073) 1 NC_014215.1 transposase 1967073 tnpA 9282947 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688751.1 1965766 R 754252 CDS YP_003688752.1 297626989 9284379 complement(1967040..1967114) 1 NC_014215.1 hypothetical protein 1967114 9284379 PFREUD_18240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688752.1 1967040 R 754252 CDS YP_003688753.1 297626990 9282948 1967288..1968241 1 NC_014215.1 hypothetical protein 1968241 9282948 PFREUD_18250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688753.1 1967288 D 754252 CDS YP_003688754.1 297626991 9282949 1968260..1968853 1 NC_014215.1 hypothetical protein 1968853 9282949 PFREUD_18260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688754.1 1968260 D 754252 CDS YP_003688755.1 297626992 9282950 1969294..1970259 1 NC_014215.1 transposase 1970259 tnpA 9282950 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688755.1 1969294 D 754252 CDS YP_003688756.1 297626993 9284380 complement(1970570..1971952) 1 NC_014215.1 S-layer protein 1971952 9284380 PFREUD_18270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S-layer protein YP_003688756.1 1970570 R 754252 CDS YP_003688757.1 297626994 9282951 complement(1971885..1972100) 1 NC_014215.1 hypothetical protein 1972100 9282951 PFREUD_18280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688757.1 1971885 R 754252 CDS YP_003688758.1 297626995 9282952 complement(1972601..1974232) 1 NC_014215.1 several slp were identified in P. freudenreichii; surface layer protein A 1974232 slpA 9282952 slpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 surface layer protein A YP_003688758.1 1972601 R 754252 CDS YP_003688759.1 297626996 9284285 complement(1974830..1975390) 1 NC_014215.1 hydrolyse a wide range of organic pyrophosphates, polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. MicrotT, have the ability to degrade potentially mutagenic, oxidised nucleotides while others control the levels of metabolic intermediates and signalling compounds. McLennan AG cell Mol Life Sci. 2006 Jan;63(2):123-43; NUDIX hydrolase 1975390 9284285 PFREUD_18300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003688759.1 1974830 R 754252 CDS YP_003688760.1 297626997 9282953 complement(1982176..1983798) 1 NC_014215.1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. groL1 and groL2 are expressed as 2 distinct heat shock proteins; molecular chaperone groEL 1983798 groL2 9282953 groL2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone groEL YP_003688760.1 1982176 R 754252 CDS YP_003688761.1 297626998 9283661 complement(1984142..1984423) 1 NC_014215.1 hypothetical protein 1984423 9283661 PFREUD_18480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688761.1 1984142 R 754252 CDS YP_003688762.1 297626999 9282954 1984642..1985841 1 NC_014215.1 D-Mannose 6-phosphate <=> D-Fructose 6-phosphate and D-Mannose 6-phosphate <=> beta-D-Fructose 6-phosphate; phosphomannose isomerase 1985841 manA 9282954 manA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphomannose isomerase YP_003688762.1 1984642 D 754252 CDS YP_003688763.1 297627000 9282955 1986330..1988660 1 NC_014215.1 drug exporters of the RND superfamily 1988660 9282955 PFREUD_18510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 drug exporters of the RND superfamily YP_003688763.1 1986330 D 754252 CDS YP_003688764.1 297627001 9282956 complement(1988781..1990922) 1 NC_014215.1 TrkA, potassium transporter 1990922 9282956 PFREUD_18520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TrkA, potassium transporter YP_003688764.1 1988781 R 754252 CDS YP_003688765.1 297627002 9282957 complement(1990929..1991312) 1 NC_014215.1 hypothetical protein 1991312 9282957 PFREUD_18530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688765.1 1990929 R 754252 CDS YP_003688766.1 297627003 9282958 1991397..1991906 1 NC_014215.1 hypothetical protein 1991906 9282958 PFREUD_18540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688766.1 1991397 D 754252 CDS YP_003688767.1 297627004 9282959 complement(1991931..1992941) 1 NC_014215.1 hypothetical protein 1992941 9282959 PFREUD_18550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688767.1 1991931 R 754252 CDS YP_003688768.1 297627005 9282960 complement(1993015..1994289) 1 NC_014215.1 peptidase, M20/M25/M40 family 1994289 9282960 PFREUD_18560 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase, M20/M25/M40 family YP_003688768.1 1993015 R 754252 CDS YP_003688769.1 297627006 9282961 1994444..1995856 1 NC_014215.1 L-serine <=> pyruvate + NH3 / alpha-amino acid <=> 2-Oxo acid + NH3 L-serine <=> 2-aminoacrylate + H2O /; L-serine dehydratase 1995856 sdaA 9282961 sdaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-serine dehydratase YP_003688769.1 1994444 D 754252 CDS YP_003688770.1 297627007 9284263 1996084..1997181 1 NC_014215.1 ABC transporter ATP-binding protein 1997181 9284263 PFREUD_18580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688770.1 1996084 D 754252 CDS YP_003688771.1 297627008 9282962 1997431..1998618 1 NC_014215.1 cystathionine gamma-synthase 1998618 metB 9282962 metB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cystathionine gamma-synthase YP_003688771.1 1997431 D 754252 CDS YP_003688772.1 297627009 9283876 1998732..2000114 1 NC_014215.1 hypothetical protein 2000114 9283876 PFREUD_18600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688772.1 1998732 D 754252 CDS YP_003688773.1 297627010 9282963 complement(2000171..2000572) 1 NC_014215.1 hypothetical protein 2000572 9282963 PFREUD_18610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688773.1 2000171 R 754252 CDS YP_003688775.1 297627012 9282965 complement(2000814..2001470) 1 NC_014215.1 hypothetical protein 2001470 9282965 PFREUD_18630 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688775.1 2000814 R 754252 CDS YP_003688776.1 297627013 9282966 complement(2001476..2003014) 1 NC_014215.1 iron-sulfur protein 2003014 9282966 PFREUD_18640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 iron-sulfur protein YP_003688776.1 2001476 R 754252 CDS YP_003688777.1 297627014 9282967 complement(2003011..2003820) 1 NC_014215.1 Oxidoreductase 2003820 9282967 PFREUD_18650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Oxidoreductase YP_003688777.1 2003011 R 754252 CDS YP_003688778.1 297627015 9282968 complement(2003861..2005624) 1 NC_014215.1 L-lactate permease 2005624 lldP 9282968 lldP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-lactate permease YP_003688778.1 2003861 R 754252 CDS YP_003688779.1 297627016 9283831 2005999..2007069 1 NC_014215.1 transcriptional regulator 2007069 9283831 PFREUD_18670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688779.1 2005999 D 754252 CDS YP_003688780.1 297627017 9282969 2007196..2008599 1 NC_014215.1 ATP + L-cysteine + tRNA(Cys) <=> AMP + Pyrophosphate + L-Cysteinyl-tRNA(Cys); cysteinyl-tRNA synthetase 2008599 cysS2 9282969 cysS2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cysteinyl-tRNA synthetase YP_003688780.1 2007196 D 754252 CDS YP_003688781.1 297627018 9283467 2008599..2009522 1 NC_014215.1 tRNA/rRNA methyltransferase 2009522 9283467 PFREUD_18690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA/rRNA methyltransferase YP_003688781.1 2008599 D 754252 CDS YP_003688782.1 297627019 9282970 2009734..2011221 1 NC_014215.1 amino acid ABC transporter permease 2011221 9282970 PFREUD_18700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003688782.1 2009734 D 754252 CDS YP_003688784.1 297627021 9282972 2011540..2013030 1 NC_014215.1 amino acid ABC transporter permease 2013030 9282972 PFREUD_18720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003688784.1 2011540 D 754252 CDS YP_003688785.1 297627022 9282973 2012972..2014042 1 NC_014215.1 L-asparagine + H2O = L-aspartate + NH3.; L-asparaginase I 2014042 ansA 9282973 ansA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-asparaginase I YP_003688785.1 2012972 D 754252 CDS YP_003688786.1 297627023 9283313 2014263..2015711 1 NC_014215.1 * 5,10-methylenetetrahydrofolate + glycine + H2O <=> Tetrahydrofolate + L-serine; glycine hydroxymethyltransferase 2015711 glyA 9283313 glyA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine hydroxymethyltransferase YP_003688786.1 2014263 D 754252 CDS YP_003688787.1 297627024 9283643 complement(2015911..2016411) 1 NC_014215.1 regulated by CarD; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2016411 ispF 9283643 ispF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_003688787.1 2015911 R 754252 CDS YP_003688788.1 297627025 9283795 complement(2016408..2017154) 1 NC_014215.1 transcription regulated by CarD, 2-C-methyl-D-erythritol 4-phosphate + CTP <=> 4-(Cytidine 5 prime-diphospho)-2-C-methyl-D-erythritol + Pyrophosphate; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2017154 ispD 9283795 ispD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_003688788.1 2016408 R 754252 CDS YP_003688789.1 297627026 9283793 complement(2017236..2017721) 1 NC_014215.1 probably regulates isp genes; CarD family transcriptional regulator 2017721 carD 9283793 carD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CarD family transcriptional regulator YP_003688789.1 2017236 R 754252 CDS YP_003688790.1 297627027 9283394 complement(2017862..2018539) 1 NC_014215.1 Probably forms part of a two-component regulatory system regX3/senX3; Response regulator receiver 2018539 regX 9283394 regX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Response regulator receiver YP_003688790.1 2017862 R 754252 CDS YP_003688791.1 297627028 9284172 complement(2018545..2019732) 1 NC_014215.1 ATP + protein L-histidine = ADP + protein N-phospho-L-histidine; Sensor-like histidine kinase 2019732 senX 9284172 senX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sensor-like histidine kinase YP_003688791.1 2018545 R 754252 CDS YP_003688792.1 297627029 9284275 2020026..2020703 1 NC_014215.1 phosphate transport system protein 2020703 phoU 9284275 phoU Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphate transport system protein YP_003688792.1 2020026 D 754252 CDS YP_003688793.1 297627030 9284071 complement(2020903..2021652) 1 NC_014215.1 phosphoglycerate mutase 2021652 gpm2 9284071 gpm2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate mutase YP_003688793.1 2020903 R 754252 CDS YP_003688794.1 297627031 9283656 2021983..2022714 1 NC_014215.1 Regulatory protein 2022714 9283656 PFREUD_18820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Regulatory protein YP_003688794.1 2021983 D 754252 CDS YP_003688795.1 297627032 9282974 2022805..2023548 1 NC_014215.1 L-serine + NADP+ <=> 2-aminomalonate semialdehyde + NADPH + H+; serine 3-dehydrogenase 2023548 sdh 9282974 sdh Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 serine 3-dehydrogenase YP_003688795.1 2022805 D 754252 CDS YP_003688796.1 297627033 9284264 complement(2023679..2024050) 1 NC_014215.1 operon (5S +12S +1.3S). Expressed in the presence of substrate. Overexpressed in response to stress.; methylmalonyl-CoA carboxytransferase 2024050 bccp 9284264 bccp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylmalonyl-CoA carboxytransferase YP_003688796.1 2023679 R 754252 CDS YP_003688797.1 297627034 9283374 complement(2024067..2024315) 1 NC_014215.1 hypothetical protein 2024315 9283374 PFREUD_18850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688797.1 2024067 R 754252 CDS YP_003688798.1 297627035 9282975 complement(2024331..2025905) 1 NC_014215.1 operon (5S +12S +1.3S). Expressed in the presence of substrate. Overexpressed in response to stress.; methylmalonyl-CoA carboxytransferase 12S subunit 2025905 mmdA 9282975 mmdA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylmalonyl-CoA carboxytransferase 12S subunit YP_003688798.1 2024331 R 754252 CDS YP_003688799.1 297627036 9283890 complement(2025921..2027438) 1 NC_014215.1 operon transcarboxylase (5S + 12S +1.3S) The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin. Expressed in the presence of substrate. Overexpressed in response to stress.; methylmalonyl-CoA carboxytransferase 5S subunit 2027438 9283890 PFREUD_18870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylmalonyl-CoA carboxytransferase 5S subunit YP_003688799.1 2025921 R 754252 CDS YP_003688800.1 297627037 9282976 complement(2027707..2029032) 1 NC_014215.1 (S)-4-amino-5-oxopentanoate = 5-aminolevulinate Porphyrin biosynthesis by the C5 pathway; second step. Homodimer. cofactor : Pyridoxal phosphate; glutamate-1-semialdehyde 2,1-aminomutase 2029032 hemL1 9282976 hemL1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate-1-semialdehyde 2,1-aminomutase YP_003688800.1 2027707 R 754252 CDS YP_003688801.1 297627038 9283691 complement(2029090..2029809) 1 NC_014215.1 protein HemR 2029809 hemR 9283691 hemR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protein HemR YP_003688801.1 2029090 R 754252 CDS YP_003688802.1 297627039 9283694 2029918..2031381 1 NC_014215.1 involved in porphyrin synthesis; membrane-bound transport protein (HemX protein) 2031381 hemX 9283694 hemX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 membrane-bound transport protein (HemX protein) YP_003688802.1 2029918 D 754252 CDS YP_003688803.1 297627040 9283695 complement(2031410..2032408) 1 NC_014215.1 porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; delta-aminolevulinic acid dehydratase 2032408 hemB 9283695 hemB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 delta-aminolevulinic acid dehydratase YP_003688803.1 2031410 R 754252 CDS YP_003688804.1 297627041 9283685 complement(2032531..2033589) 1 NC_014215.1 Catalyzes the ferrous insertion into protoporphyrin IX. Protoporphyrin + Fe(2+) = protoheme + 2 H(+).; ferrochelatase 2033589 hemH 9283685 hemH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ferrochelatase YP_003688804.1 2032531 R 754252 CDS YP_003688805.1 297627042 9283689 complement(2033586..2035154) 1 NC_014215.1 Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Porphyrin biosynthesis; penultimate step. Protoporphyrinogen-IX + 1.5 O2 = protoporphyrin-IX + 3 H2O. Homodimer. Cofactor : 1 FAD per dimer; protoporphyrinogen oxidase 2035154 hemY 9283689 hemY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 protoporphyrinogen oxidase YP_003688805.1 2033586 R 754252 CDS YP_003688806.1 297627043 9283696 complement(2035158..2036279) 1 NC_014215.1 Fe-S oxidoreductase 2036279 9283696 PFREUD_18940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fe-S oxidoreductase YP_003688806.1 2035158 R 754252 CDS YP_003688807.1 297627044 9282977 complement(2036281..2038179) 1 NC_014215.1 Uroporphyrinogen III <=> Coproporphyrinogen III + 4 CO2 and Uroporphyrinogen I <=> Coproporphyrinogen I + 4 CO2; uroporphyrinogen decarboxylase 2038179 hemE 9282977 hemE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 uroporphyrinogen decarboxylase YP_003688807.1 2036281 R 754252 CDS YP_003688808.1 297627045 9283688 complement(2038176..2039108) 1 NC_014215.1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. Cofactor : binds 1 dipyrromethane group covalently; porphobilinogen deaminase 2039108 hemC 9283688 hemC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 porphobilinogen deaminase YP_003688808.1 2038176 R 754252 CDS YP_003688809.1 297627046 9283686 complement(2039105..2040358) 1 NC_014215.1 L-glutamyl-tRNA(Glu) + NADPH + H+ <=> (S)-4-amino-5-oxopentanoate + tRNA(Glu) + NADP+; glutamyl-tRNA reductase 2040358 hemA 9283686 hemA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamyl-tRNA reductase YP_003688809.1 2039105 R 754252 CDS YP_003688810.1 297627047 9283684 2040567..2042477 1 NC_014215.1 ATP + L-aspartate + L-glutamine + H2O <=> AMP + Pyrophosphate + L-asparagine + L-glutamate; asparagine synthase 2042477 asnB 9283684 asnB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 asparagine synthase YP_003688810.1 2040567 D 754252 CDS YP_003688811.1 297627048 9283359 2042610..2044451 1 NC_014215.1 dihydroxy-acid dehydratase 2044451 ilvD 9283359 ilvD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroxy-acid dehydratase YP_003688811.1 2042610 D 754252 CDS YP_003688812.1 297627049 9283740 complement(2044779..2045387) 1 NC_014215.1 lysine exporter protein 2045387 lysE 9283740 lysE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lysine exporter protein YP_003688812.1 2044779 R 754252 CDS YP_003688813.1 297627050 9283842 complement(2045634..2046677) 1 NC_014215.1 carbohydrate degradation, myo-inositol degradation to acetyl-CoA; 2-keto-myo-inositol dehydratase 2046677 iolE 9283842 iolE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-keto-myo-inositol dehydratase YP_003688813.1 2045634 R 754252 CDS YP_003688814.1 297627051 9283787 complement(2046732..2047079) 1 NC_014215.1 hypothetical protein 2047079 9283787 PFREUD_19020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688814.1 2046732 R 754252 CDS YP_003688815.1 297627052 9282978 complement(2047227..2048216) 1 NC_014215.1 carbohydrate degradation, myo-inositol degradation to acetyl-CoA; myo-inositol 2-dehydrogenase 2048216 iolG1 9282978 iolG1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol 2-dehydrogenase YP_003688815.1 2047227 R 754252 CDS YP_003688816.1 297627053 9283788 complement(2048530..2049606) 1 NC_014215.1 Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.; transaldolase 2049606 tal2 9283788 tal2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transaldolase YP_003688816.1 2048530 R 754252 CDS YP_003688817.1 297627054 9284314 complement(2049800..2050552) 1 NC_014215.1 GntR family transcriptional regulator 2050552 9284314 PFREUD_19050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GntR family transcriptional regulator YP_003688817.1 2049800 R 754252 CDS YP_003688818.1 297627055 9282979 2050826..2051815 1 NC_014215.1 carbohydrate degradation, myo-inositol degradation to acetyl-CoA; myo-inositol catabolism protein IolC 2051815 iolC 9282979 iolC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol catabolism protein IolC YP_003688818.1 2050826 D 754252 CDS YP_003688819.1 297627056 9283785 2051818..2052687 1 NC_014215.1 hypothetical protein 2052687 9283785 PFREUD_19070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688819.1 2051818 D 754252 CDS YP_003688820.1 297627057 9282980 2052684..2053556 1 NC_014215.1 carbohydrate degradation, myo-inositol degradation to acetyl-CoA; myo-inositol catabolism protein IolB 2053556 iolB 9282980 iolB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol catabolism protein IolB YP_003688820.1 2052684 D 754252 CDS YP_003688821.1 297627058 9283784 2053656..2055563 1 NC_014215.1 carbohydrate degradation, myo-inositol degradation to acetyl-CoA; acetolactate synthase 2055563 iolD 9283784 iolD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetolactate synthase YP_003688821.1 2053656 D 754252 CDS YP_003688822.1 297627059 9283786 2055829..2057334 1 NC_014215.1 * 3-Oxopropanoate + CoA + NAD+ <=> acetyl-CoA + CO2 + NADH + H+; myo-inositol catabolism protein IolA 2057334 iolA 9283786 iolA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol catabolism protein IolA YP_003688822.1 2055829 D 754252 CDS YP_003688823.1 297627060 9283783 2057673..2059271 1 NC_014215.1 transporter in the P.freudenreichii iol operon; myo-inositol transporter IolT3 2059271 iolT3 9283783 iolT3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol transporter IolT3 YP_003688823.1 2057673 D 754252 CDS YP_003688824.1 297627061 9283792 2059437..2060729 1 NC_014215.1 hypothetical protein 2060729 9283792 PFREUD_19120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688824.1 2059437 D 754252 CDS YP_003688825.1 297627062 9282981 2060849..2062003 1 NC_014215.1 zinc-containing alcohol dehydrogenase 2062003 9282981 PFREUD_19130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 zinc-containing alcohol dehydrogenase YP_003688825.1 2060849 D 754252 CDS YP_003688826.1 297627063 9282982 complement(2062303..2062578) 1 NC_014215.1 hypothetical protein 2062578 9282982 PFREUD_19140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688826.1 2062303 R 754252 CDS YP_003688827.1 297627064 9282983 complement(2062833..2063855) 1 NC_014215.1 D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate, cofactor : zinc; Fructose-bisphosphate aldolase class II 2063855 fba1 9282983 fba1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fructose-bisphosphate aldolase class II YP_003688827.1 2062833 R 754252 CDS YP_003688828.1 297627065 9283543 complement(2064084..2064719) 1 NC_014215.1 hypothetical protein 2064719 9283543 PFREUD_19160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688828.1 2064084 R 754252 CDS YP_003688829.1 297627066 9282984 complement(2064716..2065492) 1 NC_014215.1 tRNA/rRNA methyltransferase 2065492 spoU3 9282984 spoU3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA/rRNA methyltransferase YP_003688829.1 2064716 R 754252 CDS YP_003688830.1 297627067 9284294 2065553..2066227 1 NC_014215.1 hypothetical protein 2066227 dedD 9284294 dedD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688830.1 2065553 D 754252 CDS YP_003688831.1 297627068 9283485 complement(2066435..2067304) 1 NC_014215.1 The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain; hypothetical protein 2067304 lemA 9283485 lemA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688831.1 2066435 R 754252 CDS YP_003688832.1 297627069 9283815 complement(2067574..2068131) 1 NC_014215.1 Orotidine 5prime-phosphate + Pyrophosphate <=> Orotate + 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 2068131 pyrE 9283815 pyrE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 orotate phosphoribosyltransferase YP_003688832.1 2067574 R 754252 CDS YP_003688833.1 297627070 9284155 complement(2068211..2068819) 1 NC_014215.1 transpeptidase of Gram-positive bacteria, cleaves surface proteins at the LPXTG motif between Thr and Gly and catalyzes the formation of an amide bond between the carboxyl group of Thr and the amino group of cell-wall crossbridges.; sortase 2068819 srtA 9284155 srtA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sortase YP_003688833.1 2068211 R 754252 CDS YP_003688835.1 297627072 9282985 complement(2068971..2069888) 1 NC_014215.1 S-adenosylmethioninamine + Putrescine <=> 5prime-methylthioadenosine + Spermidine / S-adenosylmethioninamine + Spermidine <=> 5prime-methylthioadenosine + Spermine; spermidine synthase 2069888 speE 9282985 speE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 spermidine synthase YP_003688835.1 2068971 R 754252 CDS YP_003688836.1 297627073 9284291 2070103..2072094 1 NC_014215.1 The OPT family of oligopeptide transporters is distinct from the ABC pfam00005 and PTR pfam00854 transporter families.; Oligopeptide transporter, OPT family protein 2072094 9284291 PFREUD_19240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Oligopeptide transporter, OPT family protein YP_003688836.1 2070103 D 754252 CDS YP_003688837.1 297627074 9282986 complement(2072215..2074791) 1 NC_014215.1 The protein has been identified by proteomics as a 95 kDa protein induced by various stresses.several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins; ATP-dependent Clp protease B1 2074791 clpB 9282986 clpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease B1 YP_003688837.1 2072215 R 754252 CDS YP_003688838.1 297627075 9283420 complement(2075174..2076541) 1 NC_014215.1 5-aminolevulinate <=> (S)-4-amino-5-oxopentanoate; glutamate-1-semialdehyde 2,1-aminomutase 2076541 hemL2 9283420 hemL2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate-1-semialdehyde 2,1-aminomutase YP_003688838.1 2075174 R 754252 CDS YP_003688839.1 297627076 9283692 complement(2076683..2078338) 1 NC_014215.1 amino acid ABC transporter permease 2078338 potE 9283692 potE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amino acid ABC transporter permease YP_003688839.1 2076683 R 754252 CDS YP_003688840.1 297627077 9284093 complement(2078873..2080156) 1 NC_014215.1 GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP; adenylosuccinate synthetase 2080156 purA 9284093 purA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 adenylosuccinate synthetase YP_003688840.1 2078873 R 754252 CDS YP_003688841.1 297627078 9284138 complement(2080353..2080568) 1 NC_014215.1 hypothetical protein 2080568 9284138 PFREUD_19290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688841.1 2080353 R 754252 CDS YP_003688842.1 297627079 9282987 complement(2080763..2082259) 1 NC_014215.1 (S)-lactaldehyde + NAD(+) + H(2)O <=> (S)-lactate + NADH; lactaldehyde dehydrogenase 2082259 aldB 9282987 aldB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lactaldehyde dehydrogenase YP_003688842.1 2080763 R 754252 CDS YP_003688843.1 297627080 9283307 2082678..2083691 1 NC_014215.1 nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base.; purine nucleosidase 2083691 iunH 9283307 iunH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 purine nucleosidase YP_003688843.1 2082678 D 754252 CDS YP_003688844.1 297627081 9283798 complement(2083791..2084537) 1 NC_014215.1 hypothetical protein 2084537 9283798 PFREUD_19320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688844.1 2083791 R 754252 CDS YP_003688845.1 297627082 9283297 2086157..2087692 1 NC_014215.1 Could be involved in copper resistance. May have oxidase activity; multicopper oxidase 2087692 copA 9283297 copA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 multicopper oxidase YP_003688845.1 2086157 D 754252 CDS YP_003688846.1 297627083 9283443 2088118..2088462 1 NC_014215.1 transposase IS3/IS911 2088462 TnpD 9283443 TnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003688846.1 2088118 D 754252 CDS YP_003688847.1 297627084 9284411 2088495..2089382 1 NC_014215.1 transposase 2089382 tnpB 9284411 tnpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688847.1 2088495 D 754252 CDS YP_003688848.1 297627085 9284399 2089432..2089611 1 NC_014215.1 hypothetical protein 2089611 9284399 PFREUD_19360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688848.1 2089432 D 754252 CDS YP_003688849.1 297627086 9282989 2089608..2091143 1 NC_014215.1 homopolysaccharide synthesis - homology detected with tts, responsible of capsular synthesis of streptococcus pneumoniae; polysaccharide synthase 2091143 gtfF 9282989 gtfF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polysaccharide synthase YP_003688849.1 2089608 D 754252 CDS YP_003688850.1 297627087 9282990 complement(2091485..2092456) 1 NC_014215.1 metallophosphoesterase 2092456 9282990 PFREUD_19390 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metallophosphoesterase YP_003688850.1 2091485 R 754252 CDS YP_003688851.1 297627088 9282991 complement(2092453..2094660) 1 NC_014215.1 The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyses the polymerisation of murein glycan subunits.; penicillin-binding protein 2094660 ponA 9282991 ponA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 penicillin-binding protein YP_003688851.1 2092453 R 754252 CDS YP_003688852.1 297627089 9284092 2094907..2095239 1 NC_014215.1 transcription factor WhiB 2095239 whiB3 9284092 whiB3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcription factor WhiB YP_003688852.1 2094907 D 754252 CDS YP_003688853.1 297627090 9284475 2095229..2095420 1 NC_014215.1 hypothetical protein 2095420 9284475 PFREUD_19420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688853.1 2095229 D 754252 CDS YP_003688854.1 297627091 9282992 2095417..2095872 1 NC_014215.1 Inhibits protein synthesis by cleavage of mRNA; endoribonuclease L-PSP 2095872 9282992 PFREUD_19430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 endoribonuclease L-PSP YP_003688854.1 2095417 D 754252 CDS YP_003688855.1 297627092 9282993 2095880..2096638 1 NC_014215.1 endonuclease III 2096638 nth 9282993 nth Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 endonuclease III YP_003688855.1 2095880 D 754252 CDS YP_003688856.1 297627093 9283961 2096724..2097419 1 NC_014215.1 NUDIX hydrolase 2097419 9283961 PFREUD_19450 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase YP_003688856.1 2096724 D 754252 CDS YP_003688857.1 297627094 9282994 2097458..2097811 1 NC_014215.1 S4 protein 2097811 hslR 9282994 hslR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S4 protein YP_003688857.1 2097458 D 754252 CDS YP_003688858.1 297627095 9283723 complement(2097942..2099606) 1 NC_014215.1 PTS enzyme I 2099606 CE1826 9283723 CE1826 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PTS enzyme I YP_003688858.1 2097942 R 754252 CDS YP_003688859.1 297627096 9283413 2099957..2100223 1 NC_014215.1 HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane.; HPr family phosphocarrier protein 2100223 9283413 PFREUD_19480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 HPr family phosphocarrier protein YP_003688859.1 2099957 D 754252 CDS YP_003688860.1 297627097 9282995 2100337..2102982 1 NC_014215.1 Cation-transporting ATPase 2102982 9282995 PFREUD_19490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cation-transporting ATPase YP_003688860.1 2100337 D 754252 CDS YP_003688861.1 297627098 9282996 2103131..2104348 1 NC_014215.1 hypothetical protein 2104348 9282996 PFREUD_19500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688861.1 2103131 D 754252 CDS YP_003688862.1 297627099 9282997 complement(2104387..2105523) 1 NC_014215.1 hypothetical protein 2105523 9282997 PFREUD_19510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688862.1 2104387 R 754252 CDS YP_003688863.1 297627100 9282998 complement(2105520..2105999) 1 NC_014215.1 hypothetical protein 2105999 9282998 PFREUD_19520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688863.1 2105520 R 754252 CDS YP_003688864.1 297627101 9282999 complement(2106203..2106430) 1 NC_014215.1 hypothetical protein 2106430 9282999 PFREUD_19530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688864.1 2106203 R 754252 CDS YP_003688865.1 297627102 9283000 2106602..2108449 1 NC_014215.1 glycoside hydrolase 2108449 9283000 PFREUD_19540 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycoside hydrolase YP_003688865.1 2106602 D 754252 CDS YP_003688866.1 297627103 9283001 2108587..2109015 1 NC_014215.1 thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise; thioredoxin 2109015 trxA6 9283001 trxA6 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin YP_003688866.1 2108587 D 754252 CDS YP_003688867.1 297627104 9284440 2109186..2109902 1 NC_014215.1 forkhead-associated protein 2109902 9284440 PFREUD_19560 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 forkhead-associated protein YP_003688867.1 2109186 D 754252 CDS YP_003688868.1 297627105 9283002 2109905..2110378 1 NC_014215.1 involved in signal transduction mechanisms; forkhead-associated protein 2110378 9283002 PFREUD_19570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 forkhead-associated protein YP_003688868.1 2109905 D 754252 CDS YP_003688869.1 297627106 9283003 2110381..2111916 1 NC_014215.1 hypothetical protein 2111916 pf456 9283003 pf456 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688869.1 2110381 D 754252 CDS YP_003688870.1 297627107 9284049 2111907..2113301 1 NC_014215.1 cell division protein 2113301 ftsW2 9284049 ftsW2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cell division protein YP_003688870.1 2111907 D 754252 CDS YP_003688871.1 297627108 9283582 2113298..2114722 1 NC_014215.1 penicillin-binding protein 2114722 pbpA 9283582 pbpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 penicillin-binding protein YP_003688871.1 2113298 D 754252 CDS YP_003688872.1 297627109 9283999 2114814..2116604 1 NC_014215.1 ATP + protein <=> ADP + phosphoprotein; serine/threonine protein kinase 2116604 pknB 9283999 pknB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 serine/threonine protein kinase YP_003688872.1 2114814 D 754252 CDS YP_003688873.1 297627110 9284079 2116728..2118500 1 NC_014215.1 hypothetical protein 2118500 9284079 PFREUD_19620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688873.1 2116728 D 754252 CDS YP_003688874.1 297627111 9283004 complement(2118717..2119880) 1 NC_014215.1 ATP + D-Galactose <=> ADP + alpha-D-Galactose 1-phosphate; galactokinase 2119880 galK2 9283004 galK2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 galactokinase YP_003688874.1 2118717 R 754252 CDS YP_003688875.1 297627112 9283596 complement(2120055..2120627) 1 NC_014215.1 NifU-like protein 2120627 nifU2 9283596 nifU2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NifU-like protein YP_003688875.1 2120055 R 754252 CDS YP_003688876.1 297627113 9283952 complement(2120829..2122685) 1 NC_014215.1 Fe2+ transport system protein B. Molecular function: GTP binding, iron ion binding. cellular component: integral to membrane; Ferrous iron transport protein B 2122685 feoB 9283952 feoB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ferrous iron transport protein B YP_003688876.1 2120829 R 754252 CDS YP_003688877.1 297627114 9283547 complement(2122972..2123331) 1 NC_014215.1 This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.; Ferrous iron transport protein A 2123331 feoA 9283547 feoA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Ferrous iron transport protein A YP_003688877.1 2122972 R 754252 CDS YP_003688878.1 297627115 9283546 2123770..2124294 1 NC_014215.1 hypothetical protein 2124294 9283546 PFREUD_19670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688878.1 2123770 D 754252 CDS YP_003688879.1 297627116 9283005 complement(2124376..2125956) 1 NC_014215.1 Na+/H+ antiporter 2125956 9283005 PFREUD_19680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Na+/H+ antiporter YP_003688879.1 2124376 R 754252 CDS YP_003688880.1 297627117 9283006 complement(2125972..2127831) 1 NC_014215.1 hypothetical protein 2127831 9283006 PFREUD_19690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688880.1 2125972 R 754252 CDS YP_003688881.1 297627118 9283008 complement(2128306..2128785) 1 NC_014215.1 These enzymes are Zn dependent and catalyze the deamination of nucleosides. The functional enzyme is a homodimer. Cytosine deaminase catalyzes the deamination of cytosine to uracil and ammonia and is a member of the pyrimidine salvage pathway.; zinc-binding CMP/dCMP deaminase 2128785 mesJ 9283008 mesJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 zinc-binding CMP/dCMP deaminase YP_003688881.1 2128306 R 754252 CDS YP_003688882.1 297627119 9283875 complement(2128809..2129537) 1 NC_014215.1 hypothetical protein 2129537 9283875 PFREUD_19720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688882.1 2128809 R 754252 CDS YP_003688883.1 297627120 9283009 2129726..2130367 1 NC_014215.1 UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. Belongs to the UPRTase family. Pyrimidine salvage pathway.; uracil phosphoribosyltransferase 2130367 upp 9283009 upp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 uracil phosphoribosyltransferase YP_003688883.1 2129726 D 754252 CDS YP_003688884.1 297627121 9284457 complement(2130310..2131236) 1 NC_014215.1 sortase 2131236 srt 9284457 srt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sortase YP_003688884.1 2130310 R 754252 CDS YP_003688885.1 297627122 9284299 complement(2131433..2131735) 1 NC_014215.1 hypothetical protein 2131735 9284299 PFREUD_19750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688885.1 2131433 R 754252 CDS YP_003688886.1 297627123 9283010 2132748..2132822 1 NC_014215.1 hypothetical protein 2132822 9283010 PFREUD_19760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688886.1 2132748 D 754252 CDS YP_003688887.1 297627124 9283011 2132789..2134096 1 NC_014215.1 transposase 2134096 tnpA 9283011 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003688887.1 2132789 D 754252 CDS YP_003688888.1 297627125 9283558 complement(2135672..2138260) 1 NC_014215.1 surface-anchored fimbrial subunit 2138260 9283558 PFREUD_19790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 surface-anchored fimbrial subunit YP_003688888.1 2135672 R 754252 CDS YP_003688889.1 297627126 9283012 complement(2138573..2138653) 1 NC_014215.1 hypothetical protein 2138653 9283012 PFREUD_19800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688889.1 2138573 R 754252 CDS YP_003688890.1 297627127 9283013 2139375..2141258 1 NC_014215.1 GTP-binding protein TypA 2141258 typA 9283013 typA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP-binding protein TypA YP_003688890.1 2139375 D 754252 CDS YP_003688891.1 297627128 9284444 complement(2141348..2142397) 1 NC_014215.1 glycine + Tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH + H+; glycine cleavage system protein T 2142397 gcvT2 9284444 gcvT2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine cleavage system protein T YP_003688891.1 2141348 R 754252 CDS YP_003688892.1 297627129 9283607 complement(2142537..2143040) 1 NC_014215.1 hypothetical protein 2143040 9283607 PFREUD_19830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688892.1 2142537 R 754252 CDS YP_003688893.1 297627130 9283014 complement(2143057..2143218) 1 NC_014215.1 hypothetical protein 2143218 9283014 PFREUD_19840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688893.1 2143057 R 754252 CDS YP_003688895.1 297627132 9283016 2143353..2143784 1 NC_014215.1 a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not in archea; beta barrel-like fold structure; forms homodimers in which two surface cavities serve as the active site for tRNA binding.; D-tyrosyl-tRNA(Tyr) deacylase 2143784 dtd 9283016 dtd Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-tyrosyl-tRNA(Tyr) deacylase YP_003688895.1 2143353 D 754252 CDS YP_003688896.1 297627133 9283526 2143949..2144608 1 NC_014215.1 transcriptional regulator 2144608 glnR 9283526 glnR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003688896.1 2143949 D 754252 CDS YP_003688897.1 297627134 9283625 2144980..2146059 1 NC_014215.1 inositol 1-phosphate <=> D-glucose 6-phosphate. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction.; inositol-1-phosphate synthase 2146059 9283625 PFREUD_19880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inositol-1-phosphate synthase YP_003688897.1 2144980 D 754252 CDS YP_003688898.1 297627135 9283017 2146484..2147284 1 NC_014215.1 beta-hydroxyacid dehydrogenase 2147284 mmsB 9283017 mmsB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 beta-hydroxyacid dehydrogenase YP_003688898.1 2146484 D 754252 CDS YP_003688899.1 297627136 9283892 2147463..2148188 1 NC_014215.1 Benzoate degradation via hydroxylation 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 2-Oxo-2,3-dihydrofuran-5-acetate + CO2; 4-carboxymuconolactone decarboxylase 2148188 pcaC2 9283892 pcaC2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-carboxymuconolactone decarboxylase YP_003688899.1 2147463 D 754252 CDS YP_003688900.1 297627137 9284001 complement(2148220..2149248) 1 NC_014215.1 UDP-glucose 4-epimerase 2149248 galE3 9284001 galE3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 UDP-glucose 4-epimerase YP_003688900.1 2148220 R 754252 CDS YP_003688901.1 297627138 9283594 2149460..2150398 1 NC_014215.1 N-acetyltransferase GCN5 2150398 9283594 PFREUD_19920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 N-acetyltransferase GCN5 YP_003688901.1 2149460 D 754252 CDS YP_003688902.1 297627139 9283018 2150395..2152584 1 NC_014215.1 ATP + Pyrophosphate <=> ADP + Triphosphate; polyphosphate kinase 2152584 ppk 9283018 ppk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polyphosphate kinase YP_003688902.1 2150395 D 754252 CDS YP_003688903.1 297627140 9284110 2152581..2153471 1 NC_014215.1 NUDIX hydrolase NTP pyrophosphohydrolases including oxidative damage repair enzymes 2153471 9284110 PFREUD_19940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NUDIX hydrolase NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_003688903.1 2152581 D 754252 CDS YP_003688904.1 297627141 9283019 2153680..2154768 1 NC_014215.1 The complex is composed of two ATP-binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); phosphate ABC transporter substrate-binding protein 2154768 pstS 9283019 pstS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphate ABC transporter substrate-binding protein YP_003688904.1 2153680 D 754252 CDS YP_003688905.1 297627142 9284133 2154765..2155745 1 NC_014215.1 The complex is composed of two ATP-binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); ABC transporter permease 2155745 pstC 9284133 pstC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003688905.1 2154765 D 754252 CDS YP_003688906.1 297627143 9284132 2155742..2156902 1 NC_014215.1 The complex is composed of two ATP-binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); ABC transporter permease 2156902 pstA 9284132 pstA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003688906.1 2155742 D 754252 CDS YP_003688907.1 297627144 9284130 2156877..2157686 1 NC_014215.1 TC3.A.1.7 The complex is composed of two ATP-binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); phosphate ABC transporter substrate-binding protein 2157686 pstB 9284130 pstB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphate ABC transporter substrate-binding protein YP_003688907.1 2156877 D 754252 CDS YP_003688908.1 297627145 9284131 complement(2157667..2158143) 1 NC_014215.1 arsenate ion + glutaredoxin <=> arsenite + glutaredoxin disulfide; arsenate reductase 2158143 arsC 9284131 arsC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arsenate reductase YP_003688908.1 2157667 R 754252 CDS YP_003688909.1 297627146 9283346 2157731..2157817 1 NC_014215.1 hypothetical protein 2157817 9283346 PFREUD_20000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688909.1 2157731 D 754252 CDS YP_003688910.1 297627147 9283020 complement(2158119..2158493) 1 NC_014215.1 ArsR family transcriptional regulator 2158493 arsR6 9283020 arsR6 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003688910.1 2158119 R 754252 CDS YP_003688911.1 297627148 9283353 2158590..2159057 1 NC_014215.1 arsenical resistance repressor 2159057 arsD 9283353 arsD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arsenical resistance repressor YP_003688911.1 2158590 D 754252 CDS YP_003688912.1 297627149 9283347 2159054..2160829 1 NC_014215.1 arsenic ABC transporter ATPase 2160829 arsA 9283347 arsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 arsenic ABC transporter ATPase YP_003688912.1 2159054 D 754252 CDS YP_003688913.1 297627150 9283345 complement(2160912..2162153) 1 NC_014215.1 glycosyl hydrolase 2162153 9283345 PFREUD_20040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycosyl hydrolase YP_003688913.1 2160912 R 754252 CDS YP_003688914.1 297627151 9283021 complement(2162195..2163715) 1 NC_014215.1 pyridine nucleotide-disulfide oxidoreductase 2163715 9283021 PFREUD_20050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyridine nucleotide-disulfide oxidoreductase YP_003688914.1 2162195 R 754252 CDS YP_003688915.1 297627152 9283022 complement(2163831..2164490) 1 NC_014215.1 phosphoglycerate mutase 2164490 pgm/fbp 9283022 pgm/fbp Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate mutase YP_003688915.1 2163831 R 754252 CDS YP_003688916.1 297627153 9284061 complement(2164545..2166161) 1 NC_014215.1 Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O; uroporphyrinogen-III synthase 2166161 hemD 9284061 hemD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 uroporphyrinogen-III synthase YP_003688916.1 2164545 R 754252 CDS YP_003688917.1 297627154 9283687 complement(2166280..2166381) 1 NC_014215.1 hypothetical protein 2166381 9283687 PFREUD_20080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688917.1 2166280 R 754252 CDS YP_003688918.1 297627155 9283023 complement(2166651..2167511) 1 NC_014215.1 L-proline + NAD+ <=> (S)-1-Pyrroline-5-carboxylate + NADH + H+; delta 1-pyrroline-5-carboxylate reductase 2167511 9283023 PFREUD_20090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 delta 1-pyrroline-5-carboxylate reductase YP_003688918.1 2166651 R 754252 CDS YP_003688919.1 297627156 9283024 complement(2167515..2168549) 1 NC_014215.1 L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.; aspartate-semialdehyde dehydrogenase 2168549 asd 9283024 asd Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aspartate-semialdehyde dehydrogenase YP_003688919.1 2167515 R 754252 CDS YP_003688920.1 297627157 9283356 complement(2168641..2169336) 1 NC_014215.1 hypothetical protein 2169336 9283356 PFREUD_20110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688920.1 2168641 R 754252 CDS YP_003688921.1 297627158 9283025 complement(2169481..2170290) 1 NC_014215.1 hypothetical protein 2170290 9283025 PFREUD_20120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688921.1 2169481 R 754252 CDS YP_003688922.1 297627159 9283026 complement(2170364..2171215) 1 NC_014215.1 endonuclease 2171215 9283026 PFREUD_20130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 endonuclease YP_003688922.1 2170364 R 754252 CDS YP_003688923.1 297627160 9283027 2171464..2172102 1 NC_014215.1 hypothetical protein 2172102 9283027 PFREUD_20140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688923.1 2171464 D 754252 CDS YP_003688924.1 297627161 9283028 2172218..2173612 1 NC_014215.1 DNA repair protein 2173612 sms 9283028 sms Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA repair protein YP_003688924.1 2172218 D 754252 CDS YP_003688925.1 297627162 9284288 2173650..2174720 1 NC_014215.1 Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged.; DNA integrity scanning protein DisA 2174720 disA 9284288 disA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA integrity scanning protein DisA YP_003688925.1 2173650 D 754252 CDS YP_003688926.1 297627163 9283501 2174800..2175678 1 NC_014215.1 A/G-specific adenine glycosylase 2175678 mutY 9283501 mutY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 A/G-specific adenine glycosylase YP_003688926.1 2174800 D 754252 CDS YP_003688927.1 297627164 9283931 2175967..2176602 1 NC_014215.1 ABC transporter 2176602 9283931 PFREUD_20180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003688927.1 2175967 D 754252 CDS YP_003688928.1 297627165 9283029 2176628..2178298 1 NC_014215.1 locus ABC transporter PF #2140, 2141 et 2475; ABC transporter ATP-binding protein 2178298 cbiO3 9283029 cbiO3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688928.1 2176628 D 754252 CDS YP_003688929.1 297627166 9283407 2178295..2179122 1 NC_014215.1 cobalt ABC transporter permease 2179122 cbiQ1 9283407 cbiQ1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt ABC transporter permease YP_003688929.1 2178295 D 754252 CDS YP_003688930.1 297627167 9283409 2179133..2179714 1 NC_014215.1 Chorismate + NH3 <=> Anthranilate + pyruvate + H2O; cobalt ABC transporter 2179714 9283409 PFREUD_20210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cobalt ABC transporter YP_003688930.1 2179133 D 754252 CDS YP_003688932.1 297627169 9283031 2179860..2180615 1 NC_014215.1 3-Dehydroquinate <=> 3-Dehydroshikimate + H2O; 3-dehydroquinate dehydratase 2180615 aroD 9283031 aroD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-dehydroquinate dehydratase YP_003688932.1 2179860 D 754252 CDS YP_003688933.1 297627170 9283340 2180612..2181298 1 NC_014215.1 hypothetical protein 2181298 9283340 PFREUD_20240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688933.1 2180612 D 754252 CDS YP_003688934.1 297627171 9283032 complement(2181449..2184025) 1 NC_014215.1 Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins; ATP-dependent Clp protease ATP-binding protein 2184025 clpC 9283032 clpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATP-dependent Clp protease ATP-binding protein YP_003688934.1 2181449 R 754252 CDS YP_003688935.1 297627172 9283422 complement(2184890..2185210) 1 NC_014215.1 Lsr2-like protein 2185210 9283422 PFREUD_20260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Lsr2-like protein YP_003688935.1 2184890 R 754252 CDS YP_003688936.1 297627173 9283033 complement(2185820..2186365) 1 NC_014215.1 hydroxymethyldihydropteridine pyrophosphokinase 2186365 folK 9283033 folK Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hydroxymethyldihydropteridine pyrophosphokinase YP_003688936.1 2185820 R 754252 CDS YP_003688937.1 297627174 9283571 complement(2186362..2186736) 1 NC_014215.1 2-amino-4-hydroxy-6-(D-erythro-1,2, 3-trihydroxypropyl)-7, 8-dihydropteridine <=> glycolaldehyde + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine; dihydroneopterin aldolase 2186736 folB 9283571 folB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroneopterin aldolase YP_003688937.1 2186362 R 754252 CDS YP_003688938.1 297627175 9283567 complement(2186883..2187749) 1 NC_014215.1 2-amino-7, 8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-aminobenzoate <=> Pyrophosphate + dihydropteroate / 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-aminobenzoate <=> dihydropteroate + H2O; dihydropteroate synthase 2187749 folP2 9283567 folP2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydropteroate synthase YP_003688938.1 2186883 R 754252 CDS YP_003688939.1 297627176 9283573 complement(2187853..2188197) 1 NC_014215.1 GntR family transcriptional regulator 2188197 9283573 PFREUD_20300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GntR family transcriptional regulator YP_003688939.1 2187853 R 754252 CDS YP_003688940.1 297627177 9283034 complement(2188331..2189008) 1 NC_014215.1 catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate; GTP cyclohydrolase I 2189008 folE 9283034 folE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP cyclohydrolase I YP_003688940.1 2188331 R 754252 CDS YP_003688941.1 297627178 9283570 complement(2189059..2191503) 1 NC_014215.1 ATPase 2191503 9283570 PFREUD_20320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase YP_003688941.1 2189059 R 754252 CDS YP_003688942.1 297627179 9283035 complement(2191590..2192141) 1 NC_014215.1 Guanine and 6-mercaptopurine can replace hypoxanthine.; hypoxanthine phosphoribosyltransferase 2192141 hpt 9283035 hpt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypoxanthine phosphoribosyltransferase YP_003688942.1 2191590 R 754252 CDS YP_003688943.1 297627180 9283712 complement(2192247..2193236) 1 NC_014215.1 tRNA(Ile)-lysidine synthetase 2193236 tilS 9283712 tilS Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA(Ile)-lysidine synthetase YP_003688943.1 2192247 R 754252 CDS YP_003688944.1 297627181 9284342 complement(2193236..2194327) 1 NC_014215.1 hypothetical protein 2194327 9284342 PFREUD_20350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688944.1 2193236 R 754252 CDS YP_003688945.1 297627182 9283036 complement(2194458..2195828) 1 NC_014215.1 Molecular function: serine carboxypeptidase activity; D-alanyl-D-alanine-carboxypeptidase 2195828 dac 9283036 dac Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-alanyl-D-alanine-carboxypeptidase YP_003688945.1 2194458 R 754252 CDS YP_003688946.1 297627183 9283472 2195890..2196447 1 NC_014215.1 Pyrophosphate + H2O <=> 2 Orthophosphate; inorganic pyrophosphatase 2196447 9283472 PFREUD_20370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inorganic pyrophosphatase YP_003688946.1 2195890 D 754252 CDS YP_003688947.1 297627184 9283037 2196597..2197853 1 NC_014215.1 hypothetical protein 2197853 9283037 PFREUD_20380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688947.1 2196597 D 754252 CDS YP_003688948.1 297627185 9283038 2197855..2198397 1 NC_014215.1 phosphohistidine phosphatase 2198397 sixA 9283038 sixA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphohistidine phosphatase YP_003688948.1 2197855 D 754252 CDS YP_003688949.1 297627186 9284281 2198401..2199303 1 NC_014215.1 CorA, Mg2+ and Co2+ transporters 2199303 corA 9284281 corA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 CorA, Mg2+ and Co2+ transporters YP_003688949.1 2198401 D 754252 CDS YP_003688950.1 297627187 9283444 2199460..2200524 1 NC_014215.1 hypothetical protein 2200524 9283444 PFREUD_20410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688950.1 2199460 D 754252 CDS YP_003688951.1 297627188 9283039 2200686..2202047 1 NC_014215.1 ammonium transporter 2202047 9283039 PFREUD_20420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ammonium transporter YP_003688951.1 2200686 D 754252 CDS YP_003688952.1 297627189 9283040 2202044..2202382 1 NC_014215.1 In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. Homotrimer; nitrogen regulatory protein P-II 2202382 glnB 9283040 glnB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 nitrogen regulatory protein P-II YP_003688952.1 2202044 D 754252 CDS YP_003688953.1 297627190 9283623 complement(2203192..2204529) 1 NC_014215.1 RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2; flavin-containing amine oxidase 2204529 mao 9283623 mao Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 flavin-containing amine oxidase YP_003688953.1 2203192 R 754252 CDS YP_003688955.1 297627192 9283041 complement(2204723..2206174) 1 NC_014215.1 permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-serine/D-alanine/glycine transporter 2206174 cycA1 9283041 cycA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-serine/D-alanine/glycine transporter YP_003688955.1 2204723 R 754252 CDS YP_003688956.1 297627193 9283451 2206439..2207953 1 NC_014215.1 hypothetical protein 2207953 9283451 PFREUD_20470 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688956.1 2206439 D 754252 CDS YP_003688957.1 297627194 9283042 2207953..2208795 1 NC_014215.1 ABC transporter ATP-binding protein 2208795 9283042 PFREUD_20480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003688957.1 2207953 D 754252 CDS YP_003688959.1 297627196 9283045 complement(2209103..2210152) 1 NC_014215.1 PSP1 domain-containing protein 2210152 9283045 PFREUD_20510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PSP1 domain-containing protein YP_003688959.1 2209103 R 754252 CDS YP_003688960.1 297627197 9283046 complement(2210282..2211952) 1 NC_014215.1 hypothetical protein 2211952 9283046 PFREUD_20520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688960.1 2210282 R 754252 CDS YP_003688961.1 297627198 9283047 complement(2212100..2213482) 1 NC_014215.1 deoxynucleoside triphosphate + DNA <=> Pyrophosphate + DNA; DNA polymerase III subunit delta' 2213482 dnaX 9283047 dnaX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA polymerase III subunit delta' YP_003688961.1 2212100 R 754252 CDS YP_003688962.1 297627199 9283519 complement(2213726..2214364) 1 NC_014215.1 ATP + dTMP <=> ADP + dTDP and ATP + dUMP <=> ADP + dUDP; thymidylate kinase 2214364 tmk 9283519 tmk Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thymidylate kinase YP_003688962.1 2213726 R 754252 CDS YP_003688963.1 297627200 9284344 complement(2214361..2215806) 1 NC_014215.1 hypothetical protein 2215806 9284344 PFREUD_20550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688963.1 2214361 R 754252 CDS YP_003688964.1 297627201 9283048 complement(2215850..2218636) 1 NC_014215.1 DNA topoisomerase I 2218636 topA 9283048 topA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA topoisomerase I YP_003688964.1 2215850 R 754252 CDS YP_003688965.1 297627202 9284413 complement(2219044..2220561) 1 NC_014215.1 transferase 2220561 9284413 PFREUD_20570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transferase YP_003688965.1 2219044 R 754252 CDS YP_003688966.1 297627203 9283049 2220811..2223273 1 NC_014215.1 helicase 2223273 9283049 PFREUD_20580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 helicase YP_003688966.1 2220811 D 754252 CDS YP_003688967.1 297627204 9283050 complement(2223270..2224274) 1 NC_014215.1 anaerobic dimethyl sulfoxide reductase subunit C 2224274 dmsC 9283050 dmsC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic dimethyl sulfoxide reductase subunit C YP_003688967.1 2223270 R 754252 CDS YP_003688968.1 297627205 9283506 complement(2224274..2224918) 1 NC_014215.1 electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC).; anaerobic dimethyl sulfoxide reductase subunit B 2224918 dmsB 9283506 dmsB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic dimethyl sulfoxide reductase subunit B YP_003688968.1 2224274 R 754252 CDS YP_003688969.1 297627206 9283505 complement(2224932..2227607) 1 NC_014215.1 anaerobic dimethyl sulfoxide reductase subunit A 2227607 dmsA 9283505 dmsA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 anaerobic dimethyl sulfoxide reductase subunit A YP_003688969.1 2224932 R 754252 CDS YP_003688970.1 297627207 9283504 complement(2227669..2228880) 1 NC_014215.1 hypothetical protein 2228880 9283504 PFREUD_20620 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688970.1 2227669 R 754252 CDS YP_003688971.1 297627208 9283051 complement(2229096..2229974) 1 NC_014215.1 molecular chaperone TorD 2229974 torD 9283051 torD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone TorD YP_003688971.1 2229096 R 754252 CDS YP_003688972.1 297627209 9284414 2230044..2230316 1 NC_014215.1 hypothetical protein 2230316 9284414 PFREUD_20640 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688972.1 2230044 D 754252 CDS YP_003688973.1 297627210 9283052 complement(2230412..2230744) 1 NC_014215.1 hypothetical protein 2230744 9283052 PFREUD_20650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688973.1 2230412 R 754252 CDS YP_003688974.1 297627211 9283053 complement(2230906..2231364) 1 NC_014215.1 hypothetical protein 2231364 9283053 PFREUD_20660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688974.1 2230906 R 754252 CDS YP_003688975.1 297627212 9283054 complement(2231495..2231806) 1 NC_014215.1 hypothetical protein 2231806 9283054 PFREUD_20670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688975.1 2231495 R 754252 CDS YP_003688976.1 297627213 9283055 2231965..2232510 1 NC_014215.1 microcin resistance protein 2232510 9283055 PFREUD_20680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 microcin resistance protein YP_003688976.1 2231965 D 754252 CDS YP_003688977.1 297627214 9283056 complement(2232705..2233448) 1 NC_014215.1 hypothetical protein 2233448 9283056 PFREUD_20690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688977.1 2232705 R 754252 CDS YP_003688978.1 297627215 9283057 complement(2233445..2234242) 1 NC_014215.1 hypothetical protein 2234242 9283057 PFREUD_20700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688978.1 2233445 R 754252 CDS YP_003688979.1 297627216 9283058 complement(2234239..2235390) 1 NC_014215.1 ype II/IV secretion system protein. This family contains both type II and type IV pathway secretion proteins from bacteria.; secretory protein 2235390 9283058 PFREUD_20710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 secretory protein YP_003688979.1 2234239 R 754252 CDS YP_003688980.1 297627217 9283059 complement(2235377..2236396) 1 NC_014215.1 hypothetical protein 2236396 9283059 PFREUD_20720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688980.1 2235377 R 754252 CDS YP_003688981.1 297627218 9283060 2236995..2237744 1 NC_014215.1 methyltransferase 2237744 9283060 PFREUD_20730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003688981.1 2236995 D 754252 CDS YP_003688982.1 297627219 9283061 2238082..2239305 1 NC_014215.1 Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH.; sodium:proton antiporter 2239305 NhaA 9283061 NhaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sodium:proton antiporter YP_003688982.1 2238082 D 754252 CDS YP_003688983.1 297627220 9283948 2239640..2240113 1 NC_014215.1 hypothetical protein 2240113 9283948 PFREUD_20750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688983.1 2239640 D 754252 CDS YP_003688984.1 297627221 9283062 2240229..2240456 1 NC_014215.1 hypothetical protein 2240456 9283062 PFREUD_20760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688984.1 2240229 D 754252 CDS YP_003688985.1 297627222 9283063 complement(2240572..2241333) 1 NC_014215.1 hypothetical protein 2241333 9283063 PFREUD_20770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688985.1 2240572 R 754252 CDS YP_003688986.1 297627223 9283064 complement(2241568..2244057) 1 NC_014215.1 Cation-transporting ATPase 2244057 9283064 PFREUD_20780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Cation-transporting ATPase YP_003688986.1 2241568 R 754252 CDS YP_003688987.1 297627224 9283065 complement(2244168..2244380) 1 NC_014215.1 heavy metal transport/detoxification protein 2244380 9283065 PFREUD_20790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 heavy metal transport/detoxification protein YP_003688987.1 2244168 R 754252 CDS YP_003688988.1 297627225 9283066 complement(2244514..2244927) 1 NC_014215.1 hypothetical protein 2244927 9283066 PFREUD_20800 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688988.1 2244514 R 754252 CDS YP_003688989.1 297627226 9283067 2245833..2247188 1 NC_014215.1 Replicative DNA helicase 2247188 dnaB 9283067 dnaB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Replicative DNA helicase YP_003688989.1 2245833 D 754252 CDS YP_003688990.1 297627227 9283508 complement(2247317..2247847) 1 NC_014215.1 hypothetical protein 2247847 9283508 PFREUD_20820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688990.1 2247317 R 754252 CDS YP_003688991.1 297627228 9283068 2247952..2249397 1 NC_014215.1 Proton-dependent transporter. May mediate the efflux of lincomycin; lincomycin ABC transporter permease 2249397 lmrB 9283068 lmrB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 lincomycin ABC transporter permease YP_003688991.1 2247952 D 754252 CDS YP_003688992.1 297627229 9283832 complement(2249444..2250556) 1 NC_014215.1 Acceptor + NADPH + H+ <=> Reduced acceptor + NADP+; NADH-dependent flavin oxidoreductase 2250556 namA 9283832 namA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH-dependent flavin oxidoreductase YP_003688992.1 2249444 R 754252 CDS YP_003688993.1 297627230 9283942 2250711..2251529 1 NC_014215.1 methyltransferase 2251529 9283942 PFREUD_20850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase YP_003688993.1 2250711 D 754252 CDS YP_003688994.1 297627231 9283069 complement(2251612..2252181) 1 NC_014215.1 hypothetical protein 2252181 9283069 PFREUD_20860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688994.1 2251612 R 754252 CDS YP_003688995.1 297627232 9283070 2252410..2252568 1 NC_014215.1 hypothetical protein 2252568 9283070 PFREUD_20870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688995.1 2252410 D 754252 CDS YP_003688996.1 297627233 9283071 2252700..2253032 1 NC_014215.1 hypothetical protein 2253032 9283071 PFREUD_20880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688996.1 2252700 D 754252 CDS YP_003688997.1 297627234 9283072 2253221..2254453 1 NC_014215.1 hypothetical protein 2254453 9283072 PFREUD_20890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003688997.1 2253221 D 754252 CDS YP_003688998.1 297627235 9283073 complement(2254550..2256454) 1 NC_014215.1 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphoethyl)-thiazole <=> Pyrophosphate + Thiamin monophosphate; thiamine-phosphate diphosphorylase 2256454 thiC 9283073 thiC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiamine-phosphate diphosphorylase YP_003688998.1 2254550 R 754252 CDS YP_003688999.1 297627236 9284328 2256882..2258561 1 NC_014215.1 Actively transports glucose into cells by Na(+) cotransport; Na+/galactose cotransporter / Sodium/glucose cotransporter 2258561 slgT 9284328 slgT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Na+/galactose cotransporter / Sodium/glucose cotransporter YP_003688999.1 2256882 D 754252 CDS YP_003689000.1 297627237 9284282 2258583..2259083 1 NC_014215.1 hypothetical protein 2259083 9284282 PFREUD_20920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689000.1 2258583 D 754252 CDS YP_003689001.1 297627238 9283074 complement(2259290..2261389) 1 NC_014215.1 Regulator of chromosome condensation 2261389 9283074 PFREUD_20930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Regulator of chromosome condensation YP_003689001.1 2259290 R 754252 CDS YP_003689002.1 297627239 9283075 complement(2261547..2262224) 1 NC_014215.1 Iron dependent repressor 2262224 sirR 9283075 sirR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Iron dependent repressor YP_003689002.1 2261547 R 754252 CDS YP_003689003.1 297627240 9284280 2262449..2263864 1 NC_014215.1 H(+)-stimulated, highly selective, manganese uptake system; Mn2+ and Fe2+ transporter 2263864 mntH 9284280 mntH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Mn2+ and Fe2+ transporter YP_003689003.1 2262449 D 754252 CDS YP_003689005.1 297627242 9283076 complement(2264314..2264970) 1 NC_014215.1 hypothetical protein 2264970 9283076 PFREUD_20970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689005.1 2264314 R 754252 CDS YP_003689006.1 297627243 9283077 complement(2264967..2265938) 1 NC_014215.1 VWA, von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.; von Willebrand factor A 2265938 9283077 PFREUD_20980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 von Willebrand factor A YP_003689006.1 2264967 R 754252 CDS YP_003689007.1 297627244 9283078 complement(2265920..2266054) 1 NC_014215.1 hypothetical protein 2266054 9283078 PFREUD_20990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689007.1 2265920 R 754252 CDS YP_003689008.1 297627245 9283079 complement(2266080..2267387) 1 NC_014215.1 transposase 2267387 tnpA 9283079 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689008.1 2266080 R 754252 CDS YP_003689009.1 297627246 9284382 complement(2267354..2267428) 1 NC_014215.1 hypothetical protein 2267428 9284382 PFREUD_21000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689009.1 2267354 R 754252 CDS YP_003689010.1 297627247 9283080 2267516..2268328 1 NC_014215.1 AbiF, Abortive infection bacteriophage resistance protein [Defense mechanisms].; Abortive infection bacteriophage resistance protein 2268328 9283080 PFREUD_21010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Abortive infection bacteriophage resistance protein YP_003689010.1 2267516 D 754252 CDS YP_003689012.1 297627249 9283083 2271319..2271402 1 NC_014215.1 hypothetical protein 2271402 9283083 PFREUD_21040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689012.1 2271319 D 754252 CDS YP_003689013.1 297627250 9283084 2271477..2272322 1 NC_014215.1 hypothetical protein 2272322 9283084 PFREUD_21050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689013.1 2271477 D 754252 CDS YP_003689014.1 297627251 9283085 complement(2272362..2272922) 1 NC_014215.1 hypothetical protein 2272922 9283085 PFREUD_21060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689014.1 2272362 R 754252 CDS YP_003689015.1 297627252 9283086 complement(2273118..2274005) 1 NC_014215.1 transposase 2274005 tnpB 9283086 tnpB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689015.1 2273118 R 754252 CDS YP_003689016.1 297627253 9284400 complement(2274038..2274382) 1 NC_014215.1 transposase IS3/IS911 2274382 TnpD 9284400 TnpD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003689016.1 2274038 R 754252 CDS YP_003689017.1 297627254 9284412 complement(2274405..2275112) 1 NC_014215.1 hypothetical protein 2275112 9284412 PFREUD_21070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689017.1 2274405 R 754252 CDS YP_003689018.1 297627255 9283087 complement(2275270..2275779) 1 NC_014215.1 hypothetical protein 2275779 9283087 PFREUD_21080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689018.1 2275270 R 754252 CDS YP_003689019.1 297627256 9283088 2275868..2275942 1 NC_014215.1 hypothetical protein 2275942 9283088 PFREUD_21090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689019.1 2275868 D 754252 CDS YP_003689020.1 297627257 9283089 2275909..2277216 1 NC_014215.1 transposase 2277216 tnpA 9283089 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689020.1 2275909 D 754252 CDS YP_003689021.1 297627258 9284383 2277227..2277478 1 NC_014215.1 hypothetical protein 2277478 9284383 PFREUD_21100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689021.1 2277227 D 754252 CDS YP_003689022.1 297627259 9283090 2277795..2278799 1 NC_014215.1 integrase 2278799 9283090 PFREUD_24960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689022.1 2277795 D 754252 CDS YP_003689023.1 297627260 9283283 2278861..2280123 1 NC_014215.1 hypothetical protein 2280123 9283283 PFREUD_21110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689023.1 2278861 D 754252 CDS YP_003689024.1 297627261 9283091 complement(2280330..2280824) 1 NC_014215.1 GNAT family acetyltransferase 2280824 9283091 PFREUD_21120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GNAT family acetyltransferase YP_003689024.1 2280330 R 754252 CDS YP_003689025.1 297627262 9283092 complement(2280835..2281311) 1 NC_014215.1 Glyoxalase/bleomycin resistance protein/dioxygenase 2281311 9283092 PFREUD_21130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Glyoxalase/bleomycin resistance protein/dioxygenase YP_003689025.1 2280835 R 754252 CDS YP_003689026.1 297627263 9283093 complement(2281505..2283205) 1 NC_014215.1 TniA protein 2283205 tniA 9283093 tniA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TniA protein YP_003689026.1 2281505 R 754252 CDS YP_003689027.1 297627264 9284345 2283449..2285947 1 NC_014215.1 Helicase 2285947 9284345 PFREUD_21140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Helicase YP_003689027.1 2283449 D 754252 CDS YP_003689028.1 297627265 9283094 complement(2285961..2286251) 1 NC_014215.1 hypothetical protein 2286251 9283094 PFREUD_21150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689028.1 2285961 R 754252 CDS YP_003689029.1 297627266 9283095 2286330..2286842 1 NC_014215.1 hypothetical protein 2286842 9283095 PFREUD_21160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689029.1 2286330 D 754252 CDS YP_003689030.1 297627267 9283096 complement(2286947..2288119) 1 NC_014215.1 ATP + protein <=> ADP + phosphoprotein; serine/threonine protein kinase 2288119 pkn 9283096 pkn Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 serine/threonine protein kinase YP_003689030.1 2286947 R 754252 CDS YP_003689032.1 297627269 9283097 complement(2288203..2288796) 1 NC_014215.1 integrase 2288796 int 9283097 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689032.1 2288203 R 754252 CDS YP_003689033.1 297627270 9283754 2289027..2289368 1 NC_014215.1 hypothetical protein 2289368 9283754 PFREUD_21200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689033.1 2289027 D 754252 CDS YP_003689034.1 297627271 9283098 complement(2289411..2289695) 1 NC_014215.1 hypothetical protein 2289695 9283098 PFREUD_21210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689034.1 2289411 R 754252 CDS YP_003689035.1 297627272 9283099 2290059..2290211 1 NC_014215.1 hypothetical protein 2290211 9283099 PFREUD_21220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689035.1 2290059 D 754252 CDS YP_003689036.1 297627273 9283100 2290195..2290749 1 NC_014215.1 hypothetical protein 2290749 9283100 PFREUD_21230 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689036.1 2290195 D 754252 CDS YP_003689037.1 297627274 9283101 2290933..2291367 1 NC_014215.1 Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis.; peptidase S24 2291367 umuD 9283101 umuD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidase S24 YP_003689037.1 2290933 D 754252 CDS YP_003689038.1 297627275 9284455 2291343..2292662 1 NC_014215.1 deoxynucleoside triphosphate + DNA <=> Pyrophosphate + DNA; DNA-directed DNA polymerase 2292662 umuC/rumB 9284455 umuC/rumB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA-directed DNA polymerase YP_003689038.1 2291343 D 754252 CDS YP_003689039.1 297627276 9284454 complement(2292744..2293154) 1 NC_014215.1 hypothetical protein 2293154 9284454 PFREUD_21260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689039.1 2292744 R 754252 CDS YP_003689040.1 297627277 9283102 complement(2293151..2293375) 1 NC_014215.1 hypothetical protein 2293375 9283102 PFREUD_21270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689040.1 2293151 R 754252 CDS YP_003689041.1 297627278 9283103 complement(2293377..2293445) 1 NC_014215.1 hypothetical protein 2293445 9283103 PFREUD_21280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689041.1 2293377 R 754252 CDS YP_003689042.1 297627279 9283104 complement(2293462..2294127) 1 NC_014215.1 hypothetical protein 2294127 9283104 PFREUD_21290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689042.1 2293462 R 754252 CDS YP_003689043.1 297627280 9283105 2294612..2295475 1 NC_014215.1 DNA primase 2295475 dnaG2 9283105 dnaG2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA primase YP_003689043.1 2294612 D 754252 CDS YP_003689044.1 297627281 9283512 2295561..2295749 1 NC_014215.1 hypothetical protein 2295749 9283512 PFREUD_21310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689044.1 2295561 D 754252 CDS YP_003689045.1 297627282 9283106 2295634..2297052 1 NC_014215.1 integrase 2297052 int 9283106 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689045.1 2295634 D 754252 CDS YP_003689046.1 297627283 9283775 2297202..2298557 1 NC_014215.1 Hg + NADP+ + H+ <=> Hg2+ + NADPH; pyridine nucleotide-disulfide oxidoreductase 2298557 merA 9283775 merA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyridine nucleotide-disulfide oxidoreductase YP_003689046.1 2297202 D 754252 CDS YP_003689047.1 297627284 9283872 complement(2299071..2299979) 1 NC_014215.1 integrase 2299979 int 9283872 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689047.1 2299071 R 754252 CDS YP_003689048.1 297627285 9283776 complement(2299976..2300281) 1 NC_014215.1 transposase IS3/IS911 2300281 tnpC 9283776 tnpC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003689048.1 2299976 R 754252 CDS YP_003689049.1 297627286 9284405 complement(2300320..2300601) 1 NC_014215.1 hypothetical protein 2300601 9284405 PFREUD_21330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689049.1 2300320 R 754252 CDS YP_003689050.1 297627287 9283107 2300623..2301057 1 NC_014215.1 Abortive infection bacteriophage resistance protein 2301057 abiF 9283107 abiF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Abortive infection bacteriophage resistance protein YP_003689050.1 2300623 D 754252 CDS YP_003689051.1 297627288 9284384 2301078..2301374 1 NC_014215.1 hypothetical protein 2301374 9284384 PFREUD_21350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689051.1 2301078 D 754252 CDS YP_003689052.1 297627289 9283108 2302258..2302887 1 NC_014215.1 hypothetical protein 2302887 9283108 PFREUD_21360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689052.1 2302258 D 754252 CDS YP_003689053.1 297627290 9283109 2302968..2303159 1 NC_014215.1 hypothetical protein 2303159 9283109 PFREUD_21370 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689053.1 2302968 D 754252 CDS YP_003689054.1 297627291 9283110 2303116..2303385 1 NC_014215.1 type I restriction-modification system DNA methylase 2303385 hsdM2 9283110 hsdM2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 type I restriction-modification system DNA methylase YP_003689054.1 2303116 D 754252 CDS YP_003689055.1 297627292 9283720 2303386..2305386 1 NC_014215.1 Biological process: DNA methylation, N-methyltransferase activity. S-adenosyl-L-methionine + DNA adenine <=> S-adenosyl-L-homocysteine + DNA 6-methylaminopurine; DNA methylase 2305386 modB 9283720 modB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DNA methylase YP_003689055.1 2303386 D 754252 CDS YP_003689056.1 297627293 9283898 2305386..2307959 1 NC_014215.1 highly similar to Q6A7B6_PROAC from Propionibacterium acnes; type III restriction enzyme 2307959 9283898 PFREUD_21400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 type III restriction enzyme YP_003689056.1 2305386 D 754252 CDS YP_003689057.1 297627294 9283111 2308128..2308763 1 NC_014215.1 hypothetical protein 2308763 9283111 PFREUD_21410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689057.1 2308128 D 754252 CDS YP_003689058.1 297627295 9283112 2308869..2309969 1 NC_014215.1 hypothetical protein 2309969 9283112 PFREUD_21420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689058.1 2308869 D 754252 CDS YP_003689059.1 297627296 9283113 2310271..2311779 1 NC_014215.1 malate transporter yflS 2311779 citT 9283113 citT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 malate transporter yflS YP_003689059.1 2310271 D 754252 CDS YP_003689060.1 297627297 9283419 complement(2311936..2312358) 1 NC_014215.1 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine <=> riboflavin + 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine; 6,7-dimethyl-8-ribityllumazine synthase 2312358 ribH 9283419 ribH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 6,7-dimethyl-8-ribityllumazine synthase YP_003689060.1 2311936 R 754252 CDS YP_003689061.1 297627298 9284178 complement(2312400..2313869) 1 NC_014215.1 GTP + 3 H2O <=> formate + 2,5-diamino-6-(5p-phosphoribosylamino)-4-pyrimidineone + Pyrophosphate; GTP cyclohydrolase II 2313869 ribAB 9284178 ribAB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GTP cyclohydrolase II YP_003689061.1 2312400 R 754252 CDS YP_003689062.1 297627299 9284174 complement(2313866..2314528) 1 NC_014215.1 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine <=> riboflavin + 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine; riboflavin synthase subunit alpha 2314528 ribC 9284174 ribC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 riboflavin synthase subunit alpha YP_003689062.1 2313866 R 754252 CDS YP_003689063.1 297627300 9284175 complement(2314618..2315838) 1 NC_014215.1 2, 5-diamino-6-(5-phosphoribosylamino)-4-pyrimidineone + H2O <=> 5-amino-6-(5-phosphoribosylamino)uracil + NH3 / 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ <=> 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+; 5-amino-6-(5-phosphoribosylamino)uracil reductase 2315838 ribD 9284175 ribD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 5-amino-6-(5-phosphoribosylamino)uracil reductase YP_003689063.1 2314618 R 754252 CDS YP_003689064.1 297627301 9284176 2316239..2316598 1 NC_014215.1 hypothetical protein 2316598 9284176 PFREUD_21480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689064.1 2316239 D 754252 CDS YP_003689065.1 297627302 9283114 2316656..2317138 1 NC_014215.1 hypothetical protein 2317138 9283114 PFREUD_21490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689065.1 2316656 D 754252 CDS YP_003689066.1 297627303 9283115 2317209..2319164 1 NC_014215.1 Amylose <=> 1,4-alpha-D-glucan; 4-alpha-glucanotransferase 2319164 malQ2 9283115 malQ2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-alpha-glucanotransferase YP_003689066.1 2317209 D 754252 CDS YP_003689067.1 297627304 9283849 2319297..2319476 1 NC_014215.1 hypothetical protein 2319476 9283849 PFREUD_21510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689067.1 2319297 D 754252 CDS YP_003689068.1 297627305 9283116 complement(2319776..2320093) 1 NC_014215.1 hypothetical protein 2320093 9283116 PFREUD_21520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689068.1 2319776 R 754252 CDS YP_003689069.1 297627306 9283117 complement(2320424..2321836) 1 NC_014215.1 NADH + acceptor <=> NAD(+) + reduced acceptor; NADH dehydrogenase 2321836 pntB 9283117 pntB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NADH dehydrogenase YP_003689069.1 2320424 R 754252 CDS YP_003689070.1 297627307 9284089 complement(2321843..2323396) 1 NC_014215.1 NADPH + NAD+ <=> NADP+ + NADH; NAD(P)(+) transhydrogenase 2323396 pntA 9284089 pntA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 NAD(P)(+) transhydrogenase YP_003689070.1 2321843 R 754252 CDS YP_003689071.1 297627308 9284088 2323755..2324789 1 NC_014215.1 transcriptional regulator 2324789 9284088 PFREUD_21550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003689071.1 2323755 D 754252 CDS YP_003689072.1 297627309 9283118 2325308..2326378 1 NC_014215.1 DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein.; Daunorubicin resistance ATP-binding protein DrrA 2326378 drrA 9283118 drrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Daunorubicin resistance ATP-binding protein DrrA YP_003689072.1 2325308 D 754252 CDS YP_003689073.1 297627310 9283523 2326375..2327205 1 NC_014215.1 ABC transporter permease 2327205 9283523 PFREUD_21570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter permease YP_003689073.1 2326375 D 754252 CDS YP_003689074.1 297627311 9283119 complement(2327518..2328570) 1 NC_014215.1 sulfate/thiosulfate import ATP-binding protein 2328570 cysA 9283119 cysA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sulfate/thiosulfate import ATP-binding protein YP_003689074.1 2327518 R 754252 CDS YP_003689075.1 297627312 9283460 complement(2328567..2329355) 1 NC_014215.1 sulfate transport system permease CysW 2329355 cysW 9283460 cysW Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sulfate transport system permease CysW YP_003689075.1 2328567 R 754252 CDS YP_003689076.1 297627313 9283469 complement(2329366..2330430) 1 NC_014215.1 sulfate ABC transporter permease 2330430 cysT 9283469 cysT Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sulfate ABC transporter permease YP_003689076.1 2329366 R 754252 CDS YP_003689077.1 297627314 9283468 complement(2330427..2331461) 1 NC_014215.1 sulfate-binding protein 2331461 9283468 PFREUD_21610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sulfate-binding protein YP_003689077.1 2330427 R 754252 CDS YP_003689078.1 297627315 9283120 2332280..2334127 1 NC_014215.1 Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O = sulfite + 6 reduced ferredoxin + 6 H+.Binds 1 siroheme per subunit Binds 1 4Fe-4S cluster per subunit; Sulfite reductase [ferredoxin] 2334127 nirA2/sir2 9283120 nirA2/sir2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Sulfite reductase [ferredoxin] YP_003689078.1 2332280 D 754252 CDS YP_003689079.1 297627316 9283953 2334091..2334873 1 NC_014215.1 phosphoadenosine phosphosulfate reductase 2334873 cysH 9283953 cysH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoadenosine phosphosulfate reductase YP_003689079.1 2334091 D 754252 CDS YP_003689080.1 297627317 9283463 2334900..2335967 1 NC_014215.1 ATP + sulfate = diphosphate + adenylyl sulfate; sulfate adenylyltransferase 2335967 mmcV/cysD 9283463 mmcV/cysD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sulfate adenylyltransferase YP_003689080.1 2334900 D 754252 CDS YP_003689081.1 297627318 9283889 2335970..2337319 1 NC_014215.1 sulfate adenylyltransferase 2337319 cysN 9283889 cysN Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sulfate adenylyltransferase YP_003689081.1 2335970 D 754252 CDS YP_003689082.1 297627319 9283465 complement(2337652..2338134) 1 NC_014215.1 ribose-5-phosphate isomerase 3 2338134 rpiB3 9283465 rpiB3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribose-5-phosphate isomerase 3 YP_003689082.1 2337652 R 754252 CDS YP_003689083.1 297627320 9284198 complement(2338469..2339149) 1 NC_014215.1 methylase 2339149 9284198 PFREUD_21670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methylase YP_003689083.1 2338469 R 754252 CDS YP_003689084.1 297627321 9283121 complement(2339160..2339957) 1 NC_014215.1 hypothetical protein 2339957 9283121 PFREUD_21680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689084.1 2339160 R 754252 CDS YP_003689085.1 297627322 9283122 2340568..2342157 1 NC_014215.1 L-aspartate oxidase 2342157 nadB2 9283122 nadB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-aspartate oxidase YP_003689085.1 2340568 D 754252 CDS YP_003689086.1 297627323 9283936 complement(2342208..2346584) 1 NC_014215.1 hypothetical protein 2346584 9283936 PFREUD_21700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689086.1 2342208 R 754252 CDS YP_003689087.1 297627324 9283943 2348069..2348893 1 NC_014215.1 Nitrite + Acceptor <=> Nitrate + Reduced acceptor; Nitrate reductase subunit delta 2348893 narJ 9283943 narJ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Nitrate reductase subunit delta YP_003689087.1 2348069 D 754252 CDS YP_003689088.1 297627325 9283944 2348718..2348912 1 NC_014215.1 hypothetical protein 2348912 9283944 PFREUD_21740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689088.1 2348718 D 754252 CDS YP_003689089.1 297627326 9283125 2350901..2351320 1 NC_014215.1 Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group, Heterodimer of 2 moaD subunits and 2 moaE subunits; Molybdopterin synthase MoaE, Molybdenum cofactor biosynthesis protein E 2 2351320 moaE2 9283125 moaE2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Molybdopterin synthase MoaE, Molybdenum cofactor biosynthesis protein E 2 YP_003689089.1 2350901 D 754252 CDS YP_003689090.1 297627327 9283897 2351320..2352195 1 NC_014215.1 involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism].; Molybdenum cofactor biosynthesis protein 2352195 moeZ 9283897 moeZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Molybdenum cofactor biosynthesis protein YP_003689090.1 2351320 D 754252 CDS YP_003689091.1 297627328 9283903 2352098..2352265 1 NC_014215.1 hypothetical protein 2352265 9283903 PFREUD_21780 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689091.1 2352098 D 754252 CDS YP_003689092.1 297627329 9283126 2352252..2353682 1 NC_014215.1 Involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes. Seems to be involved in a step of activation of molybdenum in the form of thiomolybdenum.; molybdenum cofactor biosynthesis protein 2353682 moeA2 9283126 moeA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molybdenum cofactor biosynthesis protein YP_003689092.1 2352252 D 754252 CDS YP_003689093.1 297627330 9283902 2353621..2354223 1 NC_014215.1 Together with moaA, is involved in the conversion of a guanosine derivative (5-GTP) into molybdopterin precursor Z; Molybdenum cofactor biosynthesis protein 2354223 moaC 9283902 moaC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Molybdenum cofactor biosynthesis protein YP_003689093.1 2353621 D 754252 CDS YP_003689094.1 297627331 9283896 complement(2354282..2354866) 1 NC_014215.1 Mo-molybdopterin cofactor biosynthetic process; Molybdenum cofactor biosynthesis protein 2354866 moaB 9283896 moaB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Molybdenum cofactor biosynthesis protein YP_003689094.1 2354282 R 754252 CDS YP_003689095.1 297627332 9283895 complement(2354870..2355319) 1 NC_014215.1 histidine triad (HIT) protein 2355319 hit 9283895 hit Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 histidine triad (HIT) protein YP_003689095.1 2354870 R 754252 CDS YP_003689096.1 297627333 9283710 complement(2356237..2357013) 1 NC_014215.1 hypothetical protein 2357013 9283710 PFREUD_21830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689096.1 2356237 R 754252 CDS YP_003689097.1 297627334 9283127 complement(2357010..2358248) 1 NC_014215.1 D-amino acid + H2O + Acceptor <=> 2-Oxo acid + NH3 + Reduced acceptor; DadA, glycine/D-amino acid oxidases 2358248 dadA2 9283127 dadA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 DadA, glycine/D-amino acid oxidases YP_003689097.1 2357010 R 754252 CDS YP_003689098.1 297627335 9283474 complement(2358260..2358643) 1 NC_014215.1 translation initiation inhibitor involved in amino acid or purine metabolism 2358643 9283474 PFREUD_21850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 translation initiation inhibitor involved in amino acid or purine metabolism YP_003689098.1 2358260 R 754252 CDS YP_003689099.1 297627336 9283128 complement(2358651..2359454) 1 NC_014215.1 polar amino acid ABC transporter ATP-binding protein 2359454 9283128 PFREUD_21860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter ATP-binding protein YP_003689099.1 2358651 R 754252 CDS YP_003689100.1 297627337 9283129 complement(2359524..2360384) 1 NC_014215.1 polar amino acid ABC transporter binding protein component 2360384 9283129 PFREUD_21870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter binding protein component YP_003689100.1 2359524 R 754252 CDS YP_003689101.1 297627338 9283130 complement(2360451..2361107) 1 NC_014215.1 Polar amino acid ABC transporter inner membrane subunit 2361107 9283130 PFREUD_21880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Polar amino acid ABC transporter inner membrane subunit YP_003689101.1 2360451 R 754252 CDS YP_003689102.1 297627339 9283131 complement(2361104..2361742) 1 NC_014215.1 polar amino acid ABC transporter permease 2361742 9283131 PFREUD_21890 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter permease YP_003689102.1 2361104 R 754252 CDS YP_003689103.1 297627340 9283132 complement(2361859..2362905) 1 NC_014215.1 alcohol dehydrogenase 2362905 adh 9283132 adh Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alcohol dehydrogenase YP_003689103.1 2361859 R 754252 CDS YP_003689104.1 297627341 9283299 complement(2362909..2363988) 1 NC_014215.1 hydroxyacid dehydrogenase 2363988 9283299 PFREUD_21910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hydroxyacid dehydrogenase YP_003689104.1 2362909 R 754252 CDS YP_003689105.1 297627342 9283133 complement(2363985..2365319) 1 NC_014215.1 aminotransferase 2365319 9283133 PFREUD_21920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aminotransferase YP_003689105.1 2363985 R 754252 CDS YP_003689106.1 297627343 9283134 2365499..2366995 1 NC_014215.1 translation regulator 2366995 9283134 PFREUD_21930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 translation regulator YP_003689106.1 2365499 D 754252 CDS YP_003689107.1 297627344 9283135 2367518..2367646 1 NC_014215.1 hypothetical protein 2367646 9283135 PFREUD_21940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689107.1 2367518 D 754252 CDS YP_003689108.1 297627345 9283136 complement(2367733..2367840) 1 NC_014215.1 hypothetical protein 2367840 9283136 PFREUD_21950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689108.1 2367733 R 754252 CDS YP_003689109.1 297627346 9283137 complement(2367862..2369616) 1 NC_014215.1 hypothetical protein 2369616 9283137 PFREUD_21960 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689109.1 2367862 R 754252 CDS YP_003689110.1 297627347 9283138 2369990..2371399 1 NC_014215.1 two component sensor kinase 2371399 9283138 PFREUD_21970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two component sensor kinase YP_003689110.1 2369990 D 754252 CDS YP_003689111.1 297627348 9283139 2371433..2372095 1 NC_014215.1 two component transcriptional regulator, LuxR family 2372095 9283139 PFREUD_21980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 two component transcriptional regulator, LuxR family YP_003689111.1 2371433 D 754252 CDS YP_003689112.1 297627349 9283140 2372346..2373341 1 NC_014215.1 integrase 2373341 int 9283140 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689112.1 2372346 D 754252 CDS YP_003689113.1 297627350 9283777 2373544..2374509 1 NC_014215.1 hypothetical protein 2374509 9283777 PFREUD_21990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689113.1 2373544 D 754252 CDS YP_003689114.1 297627351 9283141 2374506..2374661 1 NC_014215.1 hypothetical protein 2374661 9283141 PFREUD_22000 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689114.1 2374506 D 754252 CDS YP_003689115.1 297627352 9283142 complement(2374754..2374819) 1 NC_014215.1 hypothetical protein 2374819 9283142 PFREUD_22010 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689115.1 2374754 R 754252 CDS YP_003689116.1 297627353 9283143 2374882..2376270 1 NC_014215.1 major facilitator super family protein 2376270 9283143 PFREUD_22020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 major facilitator super family protein YP_003689116.1 2374882 D 754252 CDS YP_003689117.1 297627354 9283144 2376270..2376860 1 NC_014215.1 membrane multiple antibiotic resistance (MarC)-related protein 2376860 9283144 PFREUD_22030 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 membrane multiple antibiotic resistance (MarC)-related protein YP_003689117.1 2376270 D 754252 CDS YP_003689118.1 297627355 9283145 complement(2376871..2380563) 1 NC_014215.1 hypothetical protein 2380563 9283145 PFREUD_22040 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689118.1 2376871 R 754252 CDS YP_003689119.1 297627356 9283146 complement(2380560..2380958) 1 NC_014215.1 hypothetical protein 2380958 9283146 PFREUD_22050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689119.1 2380560 R 754252 CDS YP_003689120.1 297627357 9283147 complement(2381183..2381605) 1 NC_014215.1 hypothetical protein 2381605 9283147 PFREUD_22060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689120.1 2381183 R 754252 CDS YP_003689121.1 297627358 9283148 complement(2381580..2381804) 1 NC_014215.1 hypothetical protein 2381804 9283148 PFREUD_22070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689121.1 2381580 R 754252 CDS YP_003689122.1 297627359 9283149 complement(2381889..2382794) 1 NC_014215.1 hypothetical protein 2382794 9283149 PFREUD_22080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689122.1 2381889 R 754252 CDS YP_003689123.1 297627360 9283150 complement(2382787..2383680) 1 NC_014215.1 hypothetical protein 2383680 9283150 PFREUD_22090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689123.1 2382787 R 754252 CDS YP_003689124.1 297627361 9283151 complement(2383677..2385452) 1 NC_014215.1 type II secretion system protein E 2385452 9283151 PFREUD_22100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 type II secretion system protein E YP_003689124.1 2383677 R 754252 CDS YP_003689125.1 297627362 9283152 complement(2385449..2386486) 1 NC_014215.1 hypothetical protein 2386486 9283152 PFREUD_22110 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689125.1 2385449 R 754252 CDS YP_003689126.1 297627363 9283153 complement(2386486..2387133) 1 NC_014215.1 hypothetical protein 2387133 9283153 PFREUD_22120 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689126.1 2386486 R 754252 CDS YP_003689127.1 297627364 9283154 complement(2387740..2388429) 1 NC_014215.1 hypothetical protein 2388429 9283154 PFREUD_22130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689127.1 2387740 R 754252 CDS YP_003689128.1 297627365 9283155 2388609..2389217 1 NC_014215.1 TetR family transcriptional regulator 2389217 9283155 PFREUD_22140 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003689128.1 2388609 D 754252 CDS YP_003689129.1 297627366 9283156 2389363..2389587 1 NC_014215.1 hypothetical protein 2389587 9283156 PFREUD_22150 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689129.1 2389363 D 754252 CDS YP_003689130.1 297627367 9283157 complement(2389660..2390469) 1 NC_014215.1 metal binding protein 2390469 9283157 PFREUD_22160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 metal binding protein YP_003689130.1 2389660 R 754252 CDS YP_003689131.1 297627368 9283158 complement(2390525..2391130) 1 NC_014215.1 hypothetical protein 2391130 9283158 PFREUD_22170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689131.1 2390525 R 754252 CDS YP_003689132.1 297627369 9283159 complement(2391249..2391740) 1 NC_014215.1 hypothetical protein 2391740 9283159 PFREUD_22180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689132.1 2391249 R 754252 CDS YP_003689133.1 297627370 9283160 complement(2391792..2393906) 1 NC_014215.1 ATPase P 2393906 cadA 9283160 cadA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ATPase P YP_003689133.1 2391792 R 754252 CDS YP_003689134.1 297627371 9283387 complement(2393903..2394253) 1 NC_014215.1 arsenic resistance; ArsR family transcriptional regulator 2394253 arsR7 9283387 arsR7 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ArsR family transcriptional regulator YP_003689134.1 2393903 R 754252 CDS YP_003689135.1 297627372 9283354 2394439..2394927 1 NC_014215.1 acetyltransferase 2394927 9283354 PFREUD_22210 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 acetyltransferase YP_003689135.1 2394439 D 754252 CDS YP_003689136.1 297627373 9283161 complement(2394998..2395552) 1 NC_014215.1 hypothetical protein 2395552 9283161 PFREUD_22220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689136.1 2394998 R 754252 CDS YP_003689137.1 297627374 9283162 complement(2395635..2395979) 1 NC_014215.1 promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MERR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site.; MerR family transcriptional regulator 2395979 merR2 9283162 merR2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MerR family transcriptional regulator YP_003689137.1 2395635 R 754252 CDS YP_003689138.1 297627375 9283874 2396074..2397252 1 NC_014215.1 multidrug ABC transporter permease 2397252 9283874 PFREUD_22240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 multidrug ABC transporter permease YP_003689138.1 2396074 D 754252 CDS YP_003689139.1 297627376 9283163 2397278..2397967 1 NC_014215.1 ATP + xanthosine 5 prime-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate ; inhibiteur Psicofuranin; glutamine amidotransferase class I 2397967 guA 9283163 guA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine amidotransferase class I YP_003689139.1 2397278 D 754252 CDS YP_003689140.1 297627377 9283673 2398051..2399031 1 NC_014215.1 ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.; ribose-phosphate pyrophosphokinase 2399031 9283673 PFREUD_22260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribose-phosphate pyrophosphokinase YP_003689140.1 2398051 D 754252 CDS YP_003689141.1 297627378 9283164 complement(2399149..2399760) 1 NC_014215.1 hypothetical protein 2399760 9283164 PFREUD_22270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689141.1 2399149 R 754252 CDS YP_003689142.1 297627379 9283165 complement(2399931..2400749) 1 NC_014215.1 LmbE-like protein 2400749 9283165 PFREUD_22280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LmbE-like protein YP_003689142.1 2399931 R 754252 CDS YP_003689143.1 297627380 9283166 complement(2400746..2401975) 1 NC_014215.1 group 1 glycosyl transferase 2401975 9283166 PFREUD_22290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 group 1 glycosyl transferase YP_003689143.1 2400746 R 754252 CDS YP_003689144.1 297627381 9283167 2402148..2403005 1 NC_014215.1 hypothetical protein 2403005 9283167 PFREUD_22300 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689144.1 2402148 D 754252 CDS YP_003689145.1 297627382 9283168 complement(2403006..2404091) 1 NC_014215.1 hypothetical protein 2404091 9283168 PFREUD_22310 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689145.1 2403006 R 754252 CDS YP_003689146.1 297627383 9283169 complement(2404084..2404893) 1 NC_014215.1 hypothetical protein 2404893 9283169 PFREUD_22320 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689146.1 2404084 R 754252 CDS YP_003689147.1 297627384 9283170 2405032..2405928 1 NC_014215.1 aldose 1-epimerase 2405928 9283170 PFREUD_22330 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aldose 1-epimerase YP_003689147.1 2405032 D 754252 CDS YP_003689148.1 297627385 9283171 complement(2405996..2408284) 1 NC_014215.1 Excinuclease ATPase subunit UvrA 2408284 uvrA4 9283171 uvrA4 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Excinuclease ATPase subunit UvrA YP_003689148.1 2405996 R 754252 CDS YP_003689149.1 297627386 9284466 2408461..2408772 1 NC_014215.1 This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues.; Zinc finger protein 2408772 9284466 PFREUD_22350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Zinc finger protein YP_003689149.1 2408461 D 754252 CDS YP_003689150.1 297627387 9283172 complement(2409053..2411119) 1 NC_014215.1 transketolase 2411119 tkt 9283172 tkt Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transketolase YP_003689150.1 2409053 R 754252 CDS YP_003689151.1 297627388 9284343 complement(2411238..2412986) 1 NC_014215.1 ATP + Ribulose <=> ADP + D-Ribulose 5-phosphate; L-ribulokinase 2412986 araB 9284343 araB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-ribulokinase YP_003689151.1 2411238 R 754252 CDS YP_003689152.1 297627389 9283320 complement(2413224..2414600) 1 NC_014215.1 L-arabinose utilization protein 2414600 araM 9283320 araM Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-arabinose utilization protein YP_003689152.1 2413224 R 754252 CDS YP_003689154.1 297627391 9283173 complement(2414613..2416187) 1 NC_014215.1 carbohydrate kinase 2416187 9283173 PFREUD_22400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carbohydrate kinase YP_003689154.1 2414613 R 754252 CDS YP_003689155.1 297627392 9283321 complement(2416219..2417091) 1 NC_014215.1 arabinose operon; L-arabinose operon protein, hydrolase 2417091 araL 9283321 araL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 L-arabinose operon protein, hydrolase YP_003689155.1 2416219 R 754252 CDS YP_003689156.1 297627393 9283326 complement(2417151..2418230) 1 NC_014215.1 signal peptide (SignalP) transmembrane (TM HMM); hypothetical protein 2418230 9283326 PFREUD_22420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689156.1 2417151 R 754252 CDS YP_003689157.1 297627394 9283174 complement(2418775..2419263) 1 NC_014215.1 ribose-5-phosphate isomerase 2 2419263 rpiB2 9283174 rpiB2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribose-5-phosphate isomerase 2 YP_003689157.1 2418775 R 754252 CDS YP_003689158.1 297627395 9284197 2420082..2420765 1 NC_014215.1 Short subunit dehydrogenase 2420765 9284197 PFREUD_22440 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Short subunit dehydrogenase YP_003689158.1 2420082 D 754252 CDS YP_003689159.1 297627396 9283175 complement(2420974..2421804) 1 NC_014215.1 transcription regulation of arabinose/xylulose/ribulose operon ?; regulatory protein, DeoR family 2421804 deoR3 9283175 deoR3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 regulatory protein, DeoR family YP_003689159.1 2420974 R 754252 CDS YP_003689160.1 297627397 9283489 complement(2421966..2422718) 1 NC_014215.1 D-glyceraldehyde 3-phosphate = glycerone phosphate, homodimer; triosephosphate isomerase 2422718 tpi2 9283489 tpi2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 triosephosphate isomerase YP_003689160.1 2421966 R 754252 CDS YP_003689161.1 297627398 9284416 complement(2422793..2424511) 1 NC_014215.1 dihydroxyacetone kinase 2424511 dhaK/dhaL 9284416 dhaK/dhaL Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dihydroxyacetone kinase YP_003689161.1 2422793 R 754252 CDS YP_003689162.1 297627399 9283495 2424770..2425489 1 NC_014215.1 GntR family transcriptional regulator 2425489 9283495 PFREUD_22480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GntR family transcriptional regulator YP_003689162.1 2424770 D 754252 CDS YP_003689163.1 297627400 9283176 complement(2425528..2426835) 1 NC_014215.1 sugar ABC transporter permease 2426835 9283176 PFREUD_22490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 sugar ABC transporter permease YP_003689163.1 2425528 R 754252 CDS YP_003689164.1 297627401 9283177 complement(2426810..2427535) 1 NC_014215.1 proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.; cyclase 2427535 9283177 PFREUD_22500 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cyclase YP_003689164.1 2426810 R 754252 CDS YP_003689165.1 297627402 9283178 complement(2427675..2428319) 1 NC_014215.1 amidohydrolase 2428319 9283178 PFREUD_22510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 amidohydrolase YP_003689165.1 2427675 R 754252 CDS YP_003689166.1 297627403 9283179 complement(2428316..2429662) 1 NC_014215.1 transposase 2429662 tnpA 9283179 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689166.1 2428316 R 754252 CDS YP_003689167.1 297627404 9283182 2431359..2431838 1 NC_014215.1 hypothetical protein 2431838 9283182 PFREUD_22550 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689167.1 2431359 D 754252 CDS YP_003689168.1 297627405 9283183 2432234..2433391 1 NC_014215.1 integrase 2433391 int 9283183 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689168.1 2432234 D 754252 CDS YP_003689169.1 297627406 9283755 complement(2433528..2433695) 1 NC_014215.1 hypothetical protein 2433695 9283755 PFREUD_22570 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689169.1 2433528 R 754252 CDS YP_003689170.1 297627407 9283184 complement(2433667..2433843) 1 NC_014215.1 hypothetical protein 2433843 9283184 PFREUD_22580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689170.1 2433667 R 754252 CDS YP_003689171.1 297627408 9283185 2434132..2434416 1 NC_014215.1 hypothetical protein 2434416 9283185 PFREUD_22590 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689171.1 2434132 D 754252 CDS YP_003689172.1 297627409 9283186 2434490..2434657 1 NC_014215.1 hypothetical protein 2434657 9283186 PFREUD_22600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689172.1 2434490 D 754252 CDS YP_003689173.1 297627410 9283757 complement(2435768..2436292) 1 NC_014215.1 phage integrase/recombinase 2436292 int 9283757 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage integrase/recombinase YP_003689173.1 2435768 R 754252 CDS YP_003689174.1 297627411 9283759 complement(2436696..2437637) 1 NC_014215.1 phage integrase:phage integrase, N-terminal SAM-like 2437637 int 9283759 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phage integrase:phage integrase, N-terminal SAM-like YP_003689174.1 2436696 R 754252 CDS YP_003689175.1 297627412 9283760 2438221..2438523 1 NC_014215.1 hypothetical protein 2438523 9283760 PFREUD_22660 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689175.1 2438221 D 754252 CDS YP_003689176.1 297627413 9283188 complement(2438754..2439098) 1 NC_014215.1 hypothetical protein 2439098 9283188 PFREUD_22670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689176.1 2438754 R 754252 CDS YP_003689177.1 297627414 9283189 2439262..2441400 1 NC_014215.1 glycogen debranching enzyme activity, hydrolase activity, hydrolyzing O-glycosyl compounds; glycogen debranching protein 2441400 glgX 9283189 glgX Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycogen debranching protein YP_003689177.1 2439262 D 754252 CDS YP_003689178.1 297627415 9283617 2441470..2441898 1 NC_014215.1 hypothetical protein 2441898 9283617 PFREUD_22690 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689178.1 2441470 D 754252 CDS YP_003689179.1 297627416 9283190 2441908..2442381 1 NC_014215.1 hypothetical protein 2442381 9283190 PFREUD_22700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689179.1 2441908 D 754252 CDS YP_003689180.1 297627417 9283191 complement(2442515..2442853) 1 NC_014215.1 hypothetical protein 2442853 9283191 PFREUD_22710 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689180.1 2442515 R 754252 CDS YP_003689181.1 297627418 9283192 complement(2442879..2443682) 1 NC_014215.1 integrase 2443682 int 9283192 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689181.1 2442879 R 754252 CDS YP_003689182.1 297627419 9283778 complement(2443745..2444029) 1 NC_014215.1 transposase IS3/IS911 2444029 tnpA 9283778 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003689182.1 2443745 R 754252 CDS YP_003689183.1 297627420 9284386 2444189..2445142 1 NC_014215.1 transposase 2445142 tnpA 9284386 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689183.1 2444189 D 754252 CDS YP_003689184.1 297627421 9284387 2445081..2445533 1 NC_014215.1 hypothetical protein 2445533 9284387 PFREUD_22720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689184.1 2445081 D 754252 CDS YP_003689185.1 297627422 9283193 complement(2445495..2446538) 1 NC_014215.1 integrase core domain. integrase mediates integration of a DNA copy of the viral genome into the host chromosome.; integrase 2446538 int 9283193 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689185.1 2445495 R 754252 CDS YP_003689187.1 297627424 9283194 complement(2446566..2447081) 1 NC_014215.1 transposase 2447081 tnpA 9283194 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689187.1 2446566 R 754252 CDS YP_003689188.1 297627425 9284388 complement(2447048..2447122) 1 NC_014215.1 hypothetical protein 2447122 9284388 PFREUD_22740 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689188.1 2447048 R 754252 CDS YP_003689189.1 297627426 9283195 complement(2447287..2447868) 1 NC_014215.1 This protein catalyzes the inversion of a 3000-bp segment of phage DNA. The inversion results in a modification of the 3prime-end of the tail fiber gene and alters the host specificity.; resolvase 2447868 gin 9283195 gin Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 resolvase YP_003689189.1 2447287 R 754252 CDS YP_003689190.1 297627427 9283610 complement(2447865..2448644) 1 NC_014215.1 hypothetical protein 2448644 9283610 PFREUD_22760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689190.1 2447865 R 754252 CDS YP_003689191.1 297627428 9283196 complement(2448641..2448973) 1 NC_014215.1 transcriptional regulator 2448973 9283196 PFREUD_22770 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transcriptional regulator YP_003689191.1 2448641 R 754252 CDS YP_003689192.1 297627429 9283197 2449336..2449815 1 NC_014215.1 Belongs to the small heat shock protein (HSP20) family.These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterized by the presence of a conserved C-terminal domain of about 100 residues.; molecular chaperone Hsp20 2449815 hsp20 9283197 hsp20 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone Hsp20 YP_003689192.1 2449336 D 754252 CDS YP_003689193.1 297627430 9283724 2450068..2450532 1 NC_014215.1 Belongs to the small heat shock protein (HSP20) family.These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterized by the presence of a conserved C-terminal domain of about 100 residues.; molecular chaperone Hsp20 2450532 hsp20 9283724 hsp20 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 molecular chaperone Hsp20 YP_003689193.1 2450068 D 754252 CDS YP_003689194.1 297627431 9283726 complement(2450689..2452566) 1 NC_014215.1 Potassium transport system protein 2452566 kup 9283726 kup Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Potassium transport system protein YP_003689194.1 2450689 R 754252 CDS YP_003689195.1 297627432 9283804 complement(2452756..2452950) 1 NC_014215.1 hypothetical protein 2452950 9283804 PFREUD_22810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689195.1 2452756 R 754252 CDS YP_003689196.1 297627433 9283198 complement(2452889..2454196) 1 NC_014215.1 transposase 2454196 tnpA 9283198 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689196.1 2452889 R 754252 CDS YP_003689197.1 297627434 9283199 complement(2454679..2455968) 1 NC_014215.1 Uptake of D-glucarate; D-galactonate transporter 2455968 gudP 9283199 gudP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 D-galactonate transporter YP_003689197.1 2454679 R 754252 CDS YP_003689198.1 297627435 9283678 complement(2456195..2457106) 1 NC_014215.1 hexulose-6-phosphate isomerase 2457106 9283678 PFREUD_22840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hexulose-6-phosphate isomerase YP_003689198.1 2456195 R 754252 CDS YP_003689199.1 297627436 9283200 complement(2457220..2458563) 1 NC_014215.1 gluconate transporter 2458563 gntP 9283200 gntP Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 gluconate transporter YP_003689199.1 2457220 R 754252 CDS YP_003689200.1 297627437 9283651 complement(2458569..2459636) 1 NC_014215.1 O-phospho-4-hydroxy-L-threonine + NAD+ <=> 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+ (Cofactor biosynthesis; pyridoxine 5-phosphate biosynthesis; pyridoxine 5-phosphate from D-erythrose 4-phosphate: step 4/5.); 4-hydroxythreonine-4-phosphate dehydrogenase 2459636 pdxA2 9283651 pdxA2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 4-hydroxythreonine-4-phosphate dehydrogenase YP_003689200.1 2458569 R 754252 CDS YP_003689201.1 297627438 9284021 complement(2459872..2460318) 1 NC_014215.1 ribose-5-phosphate isomerase 1 2460318 rpiB1 9284021 rpiB1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribose-5-phosphate isomerase 1 YP_003689201.1 2459872 R 754252 CDS YP_003689202.1 297627439 9284196 complement(2460421..2461614) 1 NC_014215.1 L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.; cystathionine beta-lyase 2461614 malY 9284196 malY Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cystathionine beta-lyase YP_003689202.1 2460421 R 754252 CDS YP_003689203.1 297627440 9283850 2461782..2463908 1 NC_014215.1 Can use both glutamine or ammonia as a nitrogen source (By similarity). ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.. Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (glutamine route): step 1/1.; glutamine-dependent NAD(+) synthetase 2463908 nadE 9283850 nadE Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamine-dependent NAD(+) synthetase YP_003689203.1 2461782 D 754252 CDS YP_003689204.1 297627441 9283939 complement(2464121..2465002) 1 NC_014215.1 PadR, transcriptional regulator PadR-like family.; PadR family transcriptional regulator 2465002 9283939 PFREUD_22900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 PadR family transcriptional regulator YP_003689204.1 2464121 R 754252 CDS YP_003689205.1 297627442 9283201 complement(2465878..2466705) 1 NC_014215.1 polar amino acid ABC transporter ATP-binding protein 2466705 9283201 PFREUD_22910 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter ATP-binding protein YP_003689205.1 2465878 R 754252 CDS YP_003689206.1 297627443 9283202 complement(2466707..2467687) 1 NC_014215.1 polar amino acid ABC transporter permease 2467687 9283202 PFREUD_22920 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter permease YP_003689206.1 2466707 R 754252 CDS YP_003689207.1 297627444 9283203 complement(2467769..2468680) 1 NC_014215.1 polar amino acid ABC transporter substrate-binding protein 2468680 9283203 PFREUD_22930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter substrate-binding protein YP_003689207.1 2467769 R 754252 CDS YP_003689208.1 297627445 9283204 complement(2468847..2469758) 1 NC_014215.1 polar amino acid ABC transporter binding protein component 2469758 9283204 PFREUD_22940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter binding protein component YP_003689208.1 2468847 R 754252 CDS YP_003689209.1 297627446 9283205 complement(2469894..2470913) 1 NC_014215.1 polar amino acid ABC transporter binding protein 2470913 9283205 PFREUD_22950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 polar amino acid ABC transporter binding protein YP_003689209.1 2469894 R 754252 CDS YP_003689210.1 297627447 9283206 complement(2471294..2471866) 1 NC_014215.1 Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA). Nicotinamide + H2O <=> Nicotinate + NH3; pyrazinamidase/nicotinamidase 2471866 pncA 9283206 pncA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 pyrazinamidase/nicotinamidase YP_003689210.1 2471294 R 754252 CDS YP_003689211.1 297627448 9284085 complement(2472057..2473079) 1 NC_014215.1 LacI family transcriptional regulator 2473079 lacI2 9284085 lacI2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LacI family transcriptional regulator YP_003689211.1 2472057 R 754252 CDS YP_003689212.1 297627449 9283809 2473571..2474368 1 NC_014215.1 Hydroxypyruvate <=> 2-Hydroxy-3-oxopropanoate; hydroxypyruvate isomerase 2474368 9283809 PFREUD_22980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hydroxypyruvate isomerase YP_003689212.1 2473571 D 754252 CDS YP_003689213.1 297627450 9283207 2474514..2476142 1 NC_014215.1 myo-inositol transporter IolT1 2476142 iolT1 9283207 iolT1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol transporter IolT1 YP_003689213.1 2474514 D 754252 CDS YP_003689214.1 297627451 9283790 complement(2476182..2478188) 1 NC_014215.1 ATP + Long-subunit carboxylate + CoA <=> AMP + Pyrophosphate + acyl-CoA and ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Pyrophosphate; long-subunit-fatty-acid--CoA ligase/synthetase 2478188 PPA2234 9283790 PPA2234 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 long-subunit-fatty-acid--CoA ligase/synthetase YP_003689214.1 2476182 R 754252 CDS YP_003689215.1 297627452 9284105 complement(2478185..2478988) 1 NC_014215.1 These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites.; endonuclease IV 2478988 nfo 9284105 nfo Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 endonuclease IV YP_003689215.1 2478185 R 754252 CDS YP_003689216.1 297627453 9283947 complement(2479219..2479929) 1 NC_014215.1 hypothetical protein 2479929 9283947 PFREUD_23020 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689216.1 2479219 R 754252 CDS YP_003689217.1 297627454 9283208 complement(2480032..2481402) 1 NC_014215.1 S-layer protein 2481402 slh2 9283208 slh2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 S-layer protein YP_003689217.1 2480032 R 754252 CDS YP_003689219.1 297627456 9283209 complement(2481460..2482263) 1 NC_014215.1 integrase 2482263 int 9283209 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689219.1 2481460 R 754252 CDS YP_003689220.1 297627457 9283780 complement(2482326..2482610) 1 NC_014215.1 transposase IS3/IS911 2482610 tnpA 9283780 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003689220.1 2482326 R 754252 CDS YP_003689221.1 297627458 9284390 2483014..2483598 1 NC_014215.1 resolvase 2483598 9284390 PFREUD_23050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 resolvase YP_003689221.1 2483014 D 754252 CDS YP_003689222.1 297627459 9283210 2483743..2485074 1 NC_014215.1 transposase 2485074 tnpA 9283210 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689222.1 2483743 D 754252 CDS YP_003689223.1 297627460 9284391 complement(2485136..2485996) 1 NC_014215.1 hypothetical protein 2485996 9284391 PFREUD_23060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689223.1 2485136 R 754252 CDS YP_003689224.1 297627461 9283211 complement(2485996..2486880) 1 NC_014215.1 RpiR family transcriptional regulator 2486880 9283211 PFREUD_23070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 RpiR family transcriptional regulator YP_003689224.1 2485996 R 754252 CDS YP_003689225.1 297627462 9283212 2486904..2487824 1 NC_014215.1 (R)-Pantoate + NADP+ <=> 2-Dehydropantoate + NADPH + H+; 2-dehydropantoate 2-reductase 2487824 9283212 PFREUD_23080 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 2-dehydropantoate 2-reductase YP_003689225.1 2486904 D 754252 CDS YP_003689226.1 297627463 9283213 complement(2487847..2488587) 1 NC_014215.1 dehydrogenase 2488587 9283213 PFREUD_23090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dehydrogenase YP_003689226.1 2487847 R 754252 CDS YP_003689227.1 297627464 9283214 complement(2488783..2490090) 1 NC_014215.1 transposase 2490090 tnpA 9283214 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689227.1 2488783 R 754252 CDS YP_003689228.1 297627465 9284392 2490111..2490281 1 NC_014215.1 hypothetical protein 2490281 9284392 PFREUD_23100 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689228.1 2490111 D 754252 CDS YP_003689229.1 297627466 9283735 2491563..2492429 1 NC_014215.1 myo-inositol catabolism protein IolH 2492429 iolH 9283735 iolH Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 myo-inositol catabolism protein IolH YP_003689229.1 2491563 D 754252 CDS YP_003689230.1 297627467 9283789 2492601..2493635 1 NC_014215.1 The LacI family of proteins consist of transcriptional regulators related to the lac repressor. In this case, generally the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain; LacI family transcriptional regulator 2493635 lacI3 9283789 lacI3 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LacI family transcriptional regulator YP_003689230.1 2492601 D 754252 CDS YP_003689231.1 297627468 9283810 2494284..2495222 1 NC_014215.1 recombinant protein active on 1- naphthyl actetate and 1- naphthyl propionate; carboxylic ester hydrolase 2495222 pf667 9283810 pf667 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003689231.1 2494284 D 754252 CDS YP_003689232.1 297627469 9284051 2495479..2496246 1 NC_014215.1 glycerophosphodiester + H2O <=> Alcohol + sn-glycerol 3-phosphate; glycerophosphoryl diester phosphodiesterase 2496246 ugpQ2 9284051 ugpQ2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycerophosphoryl diester phosphodiesterase YP_003689232.1 2495479 D 754252 CDS YP_003689233.1 297627470 9284453 2496441..2497805 1 NC_014215.1 Sugar phosphate permease; MFS family transporter 2497805 9284453 PFREUD_23170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MFS family transporter YP_003689233.1 2496441 D 754252 CDS YP_003689234.1 297627471 9283216 2498119..2498889 1 NC_014215.1 ABC transporter ATP-binding protein 2498889 9283216 PFREUD_23180 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter ATP-binding protein YP_003689234.1 2498119 D 754252 CDS YP_003689235.1 297627472 9283217 complement(2499037..2500065) 1 NC_014215.1 xylose phosphate isomerase/epimerase 2500065 9283217 PFREUD_23190 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 xylose phosphate isomerase/epimerase YP_003689235.1 2499037 R 754252 CDS YP_003689236.1 297627473 9283218 complement(2500189..2501349) 1 NC_014215.1 myo-inositol + NAD+ <=> 2,4,6/3,5-Pentahydroxycyclohexanone + NADH + H+; inositol 2-dehydrogenase 2501349 9283218 PFREUD_23200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inositol 2-dehydrogenase YP_003689236.1 2500189 R 754252 CDS YP_003689237.1 297627474 9283219 complement(2501508..2502551) 1 NC_014215.1 LacI family transcriptional regulator 2502551 lacI4 9283219 lacI4 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 LacI family transcriptional regulator YP_003689237.1 2501508 R 754252 CDS YP_003689238.1 297627475 9283811 complement(2502578..2503396) 1 NC_014215.1 thiosulfate + Cyanide <=> Sulfite + thiocyanate; thiosulfate sulfurtransferase 2503396 sseB 9283811 sseB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thiosulfate sulfurtransferase YP_003689238.1 2502578 R 754252 CDS YP_003689239.1 297627476 9284303 2503808..2505220 1 NC_014215.1 L-glutamate <=> 4-aminobutanoate + CO2 L-aspartate <=> beta-alanine + CO2; glutamate decarboxylase 2505220 gadB 9284303 gadB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate decarboxylase YP_003689239.1 2503808 D 754252 CDS YP_003689240.1 297627477 9283591 2505266..2506810 1 NC_014215.1 glutamate/gamma-aminobutyrate antiporter 2506810 9283591 PFREUD_23240 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glutamate/gamma-aminobutyrate antiporter YP_003689240.1 2505266 D 754252 CDS YP_003689241.1 297627478 9283220 2507105..2509138 1 NC_014215.1 hypothetical protein 2509138 9283220 PFREUD_23250 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689241.1 2507105 D 754252 CDS YP_003689242.1 297627479 9283221 complement(2508955..2509392) 1 NC_014215.1 hypothetical protein 2509392 9283221 PFREUD_23260 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689242.1 2508955 R 754252 CDS YP_003689243.1 297627480 9283222 complement(2509403..2510977) 1 NC_014215.1 hypothetical protein 2510977 9283222 PFREUD_23270 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689243.1 2509403 R 754252 CDS YP_003689244.1 297627481 9283223 complement(2511125..2511952) 1 NC_014215.1 dehydrogenase/reductase 2511952 9283223 PFREUD_23280 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 dehydrogenase/reductase YP_003689244.1 2511125 R 754252 CDS YP_003689245.1 297627482 9283224 2512128..2512484 1 NC_014215.1 hypothetical protein 2512484 9283224 PFREUD_23290 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689245.1 2512128 D 754252 CDS YP_003689246.1 297627483 9283225 2512611..2513531 1 NC_014215.1 glycine/betaine ABC transporter ATP-binding protein 2513531 proV 9283225 proV Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine/betaine ABC transporter ATP-binding protein YP_003689246.1 2512611 D 754252 CDS YP_003689247.1 297627484 9284122 2513528..2514175 1 NC_014215.1 glycine/betaine ABC transporter 2514175 proW 9284122 proW Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine/betaine ABC transporter YP_003689247.1 2513528 D 754252 CDS YP_003689248.1 297627485 9284123 2514172..2514852 1 NC_014215.1 glycine/betaine ABC transporter permease 2514852 proZ 9284123 proZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 glycine/betaine ABC transporter permease YP_003689248.1 2514172 D 754252 CDS YP_003689249.1 297627486 9284125 complement(2514956..2516143) 1 NC_014215.1 Annotation inferred by similarity with protein ybdl E coli (swiss prot P77806); class I and II aminotransferase 2516143 aspC 9284125 aspC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 class I and II aminotransferase YP_003689249.1 2514956 R 754252 CDS YP_003689250.1 297627487 9283363 2516328..2517110 1 NC_014215.1 hypothetical protein 2517110 9283363 PFREUD_23340 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689250.1 2516328 D 754252 CDS YP_003689251.1 297627488 9283226 2517124..2517414 1 NC_014215.1 hypothetical protein 2517414 9283226 PFREUD_23350 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689251.1 2517124 D 754252 CDS YP_003689252.1 297627489 9283227 2517442..2517720 1 NC_014215.1 hypothetical protein 2517720 9283227 PFREUD_23360 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689252.1 2517442 D 754252 CDS YP_003689253.1 297627490 9283229 complement(2518085..2519536) 1 NC_014215.1 hypothetical protein 2519536 9283229 PFREUD_23380 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689253.1 2518085 R 754252 CDS YP_003689255.1 297627492 9283231 2519813..2520808 1 NC_014215.1 Binding-protein-dependent transport systems inner membrane component 2520808 9283231 PFREUD_23400 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Binding-protein-dependent transport systems inner membrane component YP_003689255.1 2519813 D 754252 CDS YP_003689256.1 297627493 9283232 2520805..2521785 1 NC_014215.1 Binding-protein-dependent transport systems inner membrane component 2521785 9283232 PFREUD_23410 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Binding-protein-dependent transport systems inner membrane component YP_003689256.1 2520805 D 754252 CDS YP_003689257.1 297627494 9283233 2521818..2523251 1 NC_014215.1 Extracellular solute-binding protein 2523251 9283233 PFREUD_23420 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Extracellular solute-binding protein YP_003689257.1 2521818 D 754252 CDS YP_003689258.1 297627495 9283234 2523531..2525072 1 NC_014215.1 major facilitator superfamily permease 2525072 9283234 PFREUD_23430 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 major facilitator superfamily permease YP_003689258.1 2523531 D 754252 CDS YP_003689259.1 297627496 9283235 complement(2525201..2525653) 1 NC_014215.1 50S ribosomal protein L9 2525653 rplI 9283235 rplI Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 50S ribosomal protein L9 YP_003689259.1 2525201 R 754252 CDS YP_003689260.1 297627497 9284205 complement(2525665..2525904) 1 NC_014215.1 30S ribosomal protein S18 2525904 rpsR 9284205 rpsR Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S18 YP_003689260.1 2525665 R 754252 CDS YP_003689261.1 297627498 9284251 complement(2526006..2526572) 1 NC_014215.1 ssDNA-binding protein 2526572 ssb 9284251 ssb Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ssDNA-binding protein YP_003689261.1 2526006 R 754252 CDS YP_003689262.1 297627499 9284301 complement(2526753..2527067) 1 NC_014215.1 30S ribosomal protein S6 2527067 rpsF 9284301 rpsF Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 30S ribosomal protein S6 YP_003689262.1 2526753 R 754252 CDS YP_003689263.1 297627500 9284240 complement(2527003..2527074) 1 NC_014215.1 hypothetical protein 2527074 9284240 PFREUD_23480 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689263.1 2527003 R 754252 CDS YP_003689264.1 297627501 9283236 2527886..2528182 1 NC_014215.1 hypothetical protein 2528182 9283236 PFREUD_23490 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689264.1 2527886 D 754252 CDS YP_003689265.1 297627502 9283237 complement(2528254..2528613) 1 NC_014215.1 Inorganic pyrophosphatase (EC:3.6.1.1) (PPase) [1, 2] is the enzyme responsible for the hydrolysis of pyrophosphate (PPi) which is formed principally as the product of the many biosynthetic reactions that utilise ATP; inorganic pyrophosphatase 2528613 ppa 9283237 ppa Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 inorganic pyrophosphatase YP_003689265.1 2528254 R 754252 CDS YP_003689266.1 297627503 9284094 complement(2529204..2529884) 1 NC_014215.1 This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyses the disproportionation of chlorite into chloride and oxygen.; chlorite dismutase 2529884 9284094 PFREUD_23510 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chlorite dismutase YP_003689266.1 2529204 R 754252 CDS YP_003689267.1 297627504 9283238 complement(2530109..2530492) 1 NC_014215.1 hypothetical protein 2530492 9283238 PFREUD_23520 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689267.1 2530109 R 754252 CDS YP_003689268.1 297627505 9283239 2530642..2531373 1 NC_014215.1 Isochorismate + H2O <=> 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate; isochorismatase hydrolase 2531373 9283239 PFREUD_23530 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 isochorismatase hydrolase YP_003689268.1 2530642 D 754252 CDS YP_003689269.1 297627506 9283748 complement(2533393..2534358) 1 NC_014215.1 transposase 2534358 tnpA 9283748 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase YP_003689269.1 2533393 R 754252 CDS YP_003689271.1 297627508 9283242 2537530..2538783 1 NC_014215.1 permease of the major facilitator superfamily protein 2538783 9283242 PFREUD_23580 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 permease of the major facilitator superfamily protein YP_003689271.1 2537530 D 754252 CDS YP_003689272.1 297627509 9283243 2538875..2539501 1 NC_014215.1 3-methyladenine DNA glycosylase 2539501 tagA 9283243 tagA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 3-methyladenine DNA glycosylase YP_003689272.1 2538875 D 754252 CDS YP_003689273.1 297627510 9284309 2539883..2541091 1 NC_014215.1 hypothetical protein 2541091 9284309 PFREUD_23600 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689273.1 2539883 D 754252 CDS YP_003689274.1 297627511 9283244 complement(2541121..2542368) 1 NC_014215.1 Starch + H2O <=> Dextrin + Starch; alpha-amylase 2542368 9283244 PFREUD_23610 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alpha-amylase YP_003689274.1 2541121 R 754252 CDS YP_003689275.1 297627512 9283245 complement(2542497..2543651) 1 NC_014215.1 alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly; GPI mannosyltransferase 2 2543651 pigV 9283245 pigV Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 GPI mannosyltransferase 2 YP_003689275.1 2542497 R 754252 CDS YP_003689276.1 297627513 9284072 complement(2543648..2545492) 1 NC_014215.1 hypothetical protein 2545492 9284072 PFREUD_23630 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689276.1 2543648 R 754252 CDS YP_003689277.1 297627514 9283246 complement(2545489..2547624) 1 NC_014215.1 peptidoglycan glycosyltransferase 2547624 mrc/ponA 9283246 mrc/ponA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peptidoglycan glycosyltransferase YP_003689277.1 2545489 R 754252 CDS YP_003689278.1 297627515 9283909 complement(2547617..2548036) 1 NC_014215.1 hypothetical protein 2548036 9283909 PFREUD_23650 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689278.1 2547617 R 754252 CDS YP_003689279.1 297627516 9283248 complement(2548452..2548835) 1 NC_014215.1 hypothetical protein 2548835 9283248 PFREUD_23670 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689279.1 2548452 R 754252 CDS YP_003689280.1 297627517 9283249 2549109..2550953 1 NC_014215.1 hypothetical protein 2550953 9283249 PFREUD_23680 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689280.1 2549109 D 754252 CDS YP_003689281.1 297627518 9283250 complement(2551231..2552085) 1 NC_014215.1 hypothetical protein 2552085 ltrA 9283250 ltrA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689281.1 2551231 R 754252 CDS YP_003689282.1 297627519 9283838 2552547..2552783 1 NC_014215.1 hypothetical protein 2552783 9283838 PFREUD_23700 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689282.1 2552547 D 754252 CDS YP_003689283.1 297627520 9283251 complement(2552843..2554057) 1 NC_014215.1 cytochrome P450 2554057 cypA 9283251 cypA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 cytochrome P450 YP_003689283.1 2552843 R 754252 CDS YP_003689284.1 297627521 9283457 complement(2554390..2555244) 1 NC_014215.1 aldo/keto reductase 2555244 9283457 PFREUD_23720 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 aldo/keto reductase YP_003689284.1 2554390 R 754252 CDS YP_003689285.1 297627522 9283252 complement(2555451..2556440) 1 NC_014215.1 hypothetical protein 2556440 9283252 PFREUD_23730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689285.1 2555451 R 754252 CDS YP_003689286.1 297627523 9283253 complement(2556706..2558448) 1 NC_014215.1 alpha-1,4-glucosidase 2558448 aglA 9283253 aglA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 alpha-1,4-glucosidase YP_003689286.1 2556706 R 754252 CDS YP_003689287.1 297627524 9283302 complement(2558511..2558996) 1 NC_014215.1 hypothetical protein 2558996 9283302 PFREUD_23750 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689287.1 2558511 R 754252 CDS YP_003689288.1 297627525 9283254 2559508..2561487 1 NC_014215.1 Xanthine/uracil permease 2561487 9283254 PFREUD_23760 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Xanthine/uracil permease YP_003689288.1 2559508 D 754252 CDS YP_003689289.1 297627526 9283255 complement(2561587..2562588) 1 NC_014215.1 carboxylic ester hydrolase 2562588 pf2042 9283255 pf2042 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 carboxylic ester hydrolase YP_003689289.1 2561587 R 754252 CDS YP_003689290.1 297627527 9284039 2563067..2564734 1 NC_014215.1 acetyl-CoA <=> Long-subunit acyl-CoA; Fatty-acyl-CoA synthase 2564734 acs 9284039 acs Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fatty-acyl-CoA synthase YP_003689290.1 2563067 D 754252 CDS YP_003689291.1 297627528 9283294 2565288..2565617 1 NC_014215.1 hypothetical protein 2565617 9283294 PFREUD_23790 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689291.1 2565288 D 754252 CDS YP_003689292.1 297627529 9283256 complement(2565735..2567183) 1 NC_014215.1 Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide, 2 H2O2 = O2 + 2 H2O , Heme group, cofactor NADPH, Homotetramer, Cytoplasm, catalase family.; catalase 2567183 katA 9283256 katA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 catalase YP_003689292.1 2565735 R 754252 CDS YP_003689293.1 297627530 9283800 complement(2567288..2568205) 1 NC_014215.1 peroxidase 2568205 9283800 PFREUD_23810 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 peroxidase YP_003689293.1 2567288 R 754252 CDS YP_003689294.1 297627531 9283257 2568767..2570719 1 NC_014215.1 ABC transporter 2570719 9283257 PFREUD_23820 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter YP_003689294.1 2568767 D 754252 CDS YP_003689295.1 297627532 9283258 complement(2571186..2571956) 1 NC_014215.1 hypothetical protein 2571956 9283258 PFREUD_23830 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689295.1 2571186 R 754252 CDS YP_003689296.1 297627533 9283259 complement(2572040..2573296) 1 NC_014215.1 chloride channel protein 2573296 9283259 PFREUD_23840 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chloride channel protein YP_003689296.1 2572040 R 754252 CDS YP_003689297.1 297627534 9283260 2573729..2574013 1 NC_014215.1 transposase IS3/IS911 2574013 tnpA 9283260 tnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase IS3/IS911 YP_003689297.1 2573729 D 754252 CDS YP_003689298.1 297627535 9284394 2574076..2574879 1 NC_014215.1 integrase 2574879 int 9284394 int Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 integrase YP_003689298.1 2574076 D 754252 CDS YP_003689299.1 297627536 9283781 2574876..2574989 1 NC_014215.1 hypothetical protein 2574989 9283781 PFREUD_23850 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689299.1 2574876 D 754252 CDS YP_003689300.1 297627537 9283261 2575456..2575755 1 NC_014215.1 hypothetical protein 2575755 9283261 PFREUD_23860 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689300.1 2575456 D 754252 CDS YP_003689301.1 297627538 9283262 complement(2576251..2576484) 1 NC_014215.1 hypothetical protein 2576484 9283262 PFREUD_23870 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689301.1 2576251 R 754252 CDS YP_003689302.1 297627539 9283263 complement(2576711..2577124) 1 NC_014215.1 hypothetical protein 2577124 9283263 PFREUD_23880 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689302.1 2576711 R 754252 CDS YP_003689303.1 297627540 9283264 complement(2577287..2578174) 1 NC_014215.1 D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate; Fructose-bisphosphate aldolase class I 2578174 fba2 9283264 fba2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Fructose-bisphosphate aldolase class I YP_003689303.1 2577287 R 754252 CDS YP_003689304.1 297627541 9283544 complement(2578557..2579108) 1 NC_014215.1 hypothetical protein 2579108 9283544 PFREUD_23900 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689304.1 2578557 R 754252 CDS YP_003689305.1 297627542 9283265 2579488..2580771 1 NC_014215.1 publication in : nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiology 140:1817-1828(1994) - acetyl-CoA + H2O + oxaloacetate = citrate + CoA. Weakly inhibited by ATP. Homohexamer. Citrate synthase is found in nearly all cells capable of oxidative metabolism.; Citrate synthase 2580771 gltA1 9283265 gltA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Citrate synthase YP_003689305.1 2579488 D 754252 CDS YP_003689306.1 297627543 9283635 2581011..2582069 1 NC_014215.1 Oxidoreductase 2582069 yghZ 9283635 yghZ Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Oxidoreductase YP_003689306.1 2581011 D 754252 CDS YP_003689307.1 297627544 9284492 2582212..2582853 1 NC_014215.1 hypothetical protein 2582853 9284492 PFREUD_23930 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689307.1 2582212 D 754252 CDS YP_003689308.1 297627545 9283266 complement(2582881..2583084) 1 NC_014215.1 hypothetical protein 2583084 9283266 PFREUD_23940 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689308.1 2582881 R 754252 CDS YP_003689309.1 297627546 9283267 complement(2583477..2585981) 1 NC_014215.1 drug exporters of the RND superfamily 2585981 9283267 PFREUD_23950 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 drug exporters of the RND superfamily YP_003689309.1 2583477 R 754252 CDS YP_003689310.1 297627547 9283268 2586195..2586881 1 NC_014215.1 TetR family transcriptional regulator 2586881 tetR1 9283268 tetR1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 TetR family transcriptional regulator YP_003689310.1 2586195 D 754252 CDS YP_003689311.1 297627548 9284320 2586939..2587595 1 NC_014215.1 Oxidoreductase 2587595 9284320 PFREUD_23970 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Oxidoreductase YP_003689311.1 2586939 D 754252 CDS YP_003689312.1 297627549 9283269 2587784..2588101 1 NC_014215.1 hypothetical protein 2588101 9283269 PFREUD_23980 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689312.1 2587784 D 754252 CDS YP_003689313.1 297627550 9283270 complement(2588141..2588932) 1 NC_014215.1 hypothetical protein 2588932 9283270 PFREUD_23990 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689313.1 2588141 R 754252 CDS YP_003689314.1 297627551 9283271 complement(2588922..2589689) 1 NC_014215.1 iron ABC transporter ATPase 2589689 fepC1 9283271 fepC1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 iron ABC transporter ATPase YP_003689314.1 2588922 R 754252 CDS YP_003689315.1 297627552 9283548 complement(2589578..2590792) 1 NC_014215.1 iron ABC transporter permease 2590792 fepD 9283548 fepD Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 iron ABC transporter permease YP_003689315.1 2589578 R 754252 CDS YP_003689316.1 297627553 9283551 complement(2590800..2591963) 1 NC_014215.1 Iron transport system substrate-binding protein ABC transporter 2591963 fepC2 9283551 fepC2 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Iron transport system substrate-binding protein ABC transporter YP_003689316.1 2590800 R 754252 CDS YP_003689317.1 297627554 9283549 2592300..2594075 1 NC_014215.1 MscS transporter, small conductance mechanosensitive ion channel 2594075 mscs 9283549 mscs Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 MscS transporter, small conductance mechanosensitive ion channel YP_003689317.1 2592300 D 754252 CDS YP_003689318.1 297627555 9283912 2594130..2595620 1 NC_014215.1 tRNA nucleotidyltransferase PcnB 2595620 pcnB 9283912 pcnB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 tRNA nucleotidyltransferase PcnB YP_003689318.1 2594130 D 754252 CDS YP_003689319.1 297627556 9284003 2596056..2597546 1 NC_014215.1 major facilitator superfamily permease 2597546 9284003 PFREUD_24050 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 major facilitator superfamily permease YP_003689319.1 2596056 D 754252 CDS YP_003689320.1 297627557 9283272 2597704..2599800 1 NC_014215.1 hypothetical protein 2599800 9283272 PFREUD_24060 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689320.1 2597704 D 754252 CDS YP_003689321.1 297627558 9283273 2600095..2601300 1 NC_014215.1 transposase for IS3514b 2601300 9283273 PFREUD_25170 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 transposase for IS3514b YP_003689321.1 2600095 D 754252 CDS YP_003689322.1 297627559 9283284 2601566..2603662 1 NC_014215.1 serine/threonine protein kinase 2603662 9283284 PFREUD_24070 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 serine/threonine protein kinase YP_003689322.1 2601566 D 754252 CDS YP_003689323.1 297627560 9283274 2603738..2604457 1 NC_014215.1 phosphoglycerate mutase/fructose-2,6-bisphosphatase 2604457 gpm1 9283274 gpm1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 phosphoglycerate mutase/fructose-2,6-bisphosphatase YP_003689323.1 2603738 D 754252 CDS YP_003689324.1 297627561 9283655 complement(2604586..2605905) 1 NC_014215.1 ABC transporter substrate-binding protein 2605905 9283655 PFREUD_24090 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ABC transporter substrate-binding protein YP_003689324.1 2604586 R 754252 CDS YP_003689325.1 297627562 9283275 2606324..2607301 1 NC_014215.1 thioredoxin reductase 2607301 trxB 9283275 trxB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin reductase YP_003689325.1 2606324 D 754252 CDS YP_003689326.1 297627563 9284441 2607475..2607798 1 NC_014215.1 thioredoxin. thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.; thioredoxin 2607798 trxA1 9284441 trxA1 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 thioredoxin YP_003689326.1 2607475 D 754252 CDS YP_003689327.1 297627564 9284435 2607798..2608244 1 NC_014215.1 Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli.; OsmC protein 2608244 osmC 9284435 osmC Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 OsmC protein YP_003689327.1 2607798 D 754252 CDS YP_003689328.1 297627565 9283988 2608216..2608299 1 NC_014215.1 hypothetical protein 2608299 9283988 PFREUD_24130 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689328.1 2608216 D 754252 CDS YP_003689329.1 297627566 9283276 complement(2608539..2609522) 1 NC_014215.1 Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication; chromosome partitioning protein 2609522 parB 9283276 parB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chromosome partitioning protein YP_003689329.1 2608539 R 754252 CDS YP_003689330.1 297627567 9283998 complement(2609519..2611216) 1 NC_014215.1 ATPases involved in chromosome partitioning; chromosome partitioning protein 2611216 parA 9283998 parA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 chromosome partitioning protein YP_003689330.1 2609519 R 754252 CDS YP_003689331.1 297627568 9283997 complement(2611468..2611629) 1 NC_014215.1 hypothetical protein 2611629 9283997 PFREUD_24160 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689331.1 2611468 R 754252 CDS YP_003689332.1 297627569 9283277 complement(2612214..2612999) 1 NC_014215.1 methyltransferase GidB 2612999 gidB 9283277 gidB Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 methyltransferase GidB YP_003689332.1 2612214 R 754252 CDS YP_003689333.1 297627570 9283799 complement(2614006..2615073) 1 NC_014215.1 Required for the insertion of integral membrane proteins into the membrane. Probably plays an essential role in the integration of proteins of the respiratory subunit complexes. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex.; hypothetical protein 2615073 oxaA 9283799 oxaA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689333.1 2614006 R 754252 CDS YP_003689334.1 297627571 9283991 complement(2615108..2615458) 1 NC_014215.1 hypothetical protein 2615458 9283991 PFREUD_24200 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689334.1 2615108 R 754252 CDS YP_003689335.1 297627572 9283278 complement(2615455..2615883) 1 NC_014215.1 ribonuclease P 2615883 rnpA 9283278 rnpA Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 ribonuclease P YP_003689335.1 2615455 R 754252 CDS YP_003689336.1 297627573 9284193 complement(2615889..2616026) 1 NC_014215.1 hypothetical protein 2616026 9284193 PFREUD_24220 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 hypothetical protein YP_003689336.1 2615889 R 754252 CDS